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Abstract Book 2018.Pdf Abstracts of Royan International Twin Congress 14th Congress on Stem Cell Biology and Technology 29-31 August 2018 Royan Institute Cell Science Research Center Tehran, Islamic Republic of Iran Scientif ic Board Abroun S. Aghdami N. Abstracts of the 14th Congress on Amini Nik S. Stem Cell Biology and Technology (2018) Ali Moghaddam K. Atari M. Contents: Baghban Eslami Nejad M. ● Collaborators ...................................................................... 3 Baharvand H. ● Chairman Wellcome Message ............................................ 5 Bahrami AR. ● Invited Speakers ................................................................. 6 Baradaran-Rafiee A. Bonakdar, SH ● Oral Presentations ............................................................ 16 Cohen-Tannoudji M. ●Poster Presentations .......................................................... 20 Dargahi L. ● Authors Index ................................................................... 52 Didar T. Ebrahimi M. Farzaneh F. Congress President: Gargett C. Fathi R, Ph.D Ghaedi K. Congress Chairperson: Gheraati M.R. Pahlevan S, Ph.D Hamidieh A.A. Hassani N. Committees Heydari S. Organizing Committee: Hosseini Salekdeh GH. Abdollahian E., B.Sc Javan M. Afsharian P., Ph.D Kageyama R. Ahmadi SE., M.Sc Kazemnejad S. Alizadeh SK., B.Sc Khademhosseini A. Azimi R., M.Sc Baharvand H., Ph.D Kemler R. Daliri L., M.Sc Kiani S. Ezabadi Z., M.Sc Kim J. Farrokh S., B.Sc Larijani B. Fathi R., Ph.D Malekzadeh R. Irani Sh., Ph.D Moghaddam MM. Kashfi F., M.Sc Lotfipanah M., M.Sc Moghaddasali R. Pahlevan S., Ph.D Mano JF. Shahverdi AH., Ph.D Mozafari M. Shahzadeh Fazeli A., Ph.D Niknejad H. Shiva M., MD Najimi M. Tavassolian R., B.Sc Samadi Kuchaksaraei A. Vosough M, MD., Ph.D Pahlavan S. Vosough Taghi Dizaj A., M.D Zarrabi M., M.D Prigione A. Rivron N. Executive Committee: Rouzafzoon R. Amirchaghmaghi E. Savatier P. Abdi F. Shahpasand K. Dadkhah F. Shahzadeh Fazeli SA. Ghadami F. Ghodsi A. Shekari F. Kouhkan A. Soleimani M. Malekzadeh F. Tahamtani Y. Mirshekar Z. Tetzlaff W. Pahlavan S. Tipper J. Roohbani Sh. Totonchi M. Sheikhan M. Taheri E. Vanderhaeghen P. Vasefi N. Vosough M. Zoghi F. 14th Congress on Stem Cell Biology and Technology (29-31 August 2018, Terhran, Iran) Collaborators in Award Jury & Scientific Board (Stem Cell)-2018 Royan Institute, Iran Iranian Stem Cell Network Iranian Council of Stem Cell Technology (ICST) Tehran University • Science Division, Biology Faculty Eberhard Karls University Tübingen, Germany • Department of Traumatology Schnarrenbergstr Eurocord Hopital, France Ferdowsi University of Mashhad, Iran • Department of Biology Fraunhofer Institute for Biomedical Engineering IBMT, Germany Hannover Medical School, Germany • Department of Stem Cells Biology ICM Institute for Brain and Spinal Cord, France Isfahan Medical University, Iran • Department of Genetic and Molecular Biology Karolinska University Hospital, Sweden • Department of Laboratory Medicine, Division of Pathology Kurdistan University of Medical Sciences, Sanandaj, Iran • Department of Anatomy, School of Medicine Murdoch Children’s Research Institute, Australia • Royal Children’s Hospital Nagoya City University, Japan National University of Ireland, Galway • Centre for Research in Medical Devices (CÚRAM) National Institute of Immunology, India San Raffaele Scientific Institute, Italy • Division of Neuroscience, Institute of Experimental Neurology (INSPe) • Diabetes Research Institute (HSR-DRI) • Complications of Diabetes Unit Tajen University, Taiwan • College of Health Sciences Tarbiat Modares University, Iran • Department of Hematology, Medical Science Faculty • Department of Anatomy, Medical Science Faculty • Department of Molecular Genetics, Medical Science Faculty Tehran University of Medical Sciences, Iran • Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital The Rockefeller University , USA • Laboratory of Stem Cell Biology and Molecular Embryology TWICORE, Centre for Experimental and Clinical Infection Research, Germany 3 14th Congress on Stem Cell Biology and Technology (29-31 August 2018, Terhran, Iran) University of Cincinnati, College of Medicine, USA • Department of Molecular Genetics University of Manitoba, Canada • Basic Medical Science Building University of Strasbourg, France The Mount Sinai Hospital, USA RIKEN Center for Biosystems Dynamics Research, Japan Cancer Research Institute of Slovak Academy of Sciences, Slovak Republic University of Wisconsin-Madison, USA 4 14th Congress on Stem Cell Biology and Technology (29-31 August 2018, Terhran, Iran) Congress Chairperson Sara Pahlevan Dear Colleagues, It is our pleasure to invite you to participate in The 14th International Congress on Stem Cell Biology and Technology taking place on 29-31 August 2018 in Tehran, Iran. Following the success of the previous events, this 14th Congress will also address areas of stem cell science from bench to market in an exciting and informative manner. With world renowned speakers secured to present ground breaking news, Royan 14th International Stem Cell Biology and Technology will be a congress to be remembered and definitely not to be missed. We know how important advances in stem cell science are. As the leading professional society for stem cell research in Iran, we are committed to building a network with international leaders in the stem cell field as a way to promote and foster the exchange of information and research. Participants will enjoy cutting-edge lectures and very active discussions by the world’s top scientists, senior researchers and postgraduate students. Topics to be covered, among others will be: 1. Current and future trends on stem cell science in ● Pluripotent Stem Cells and Adult Stem Cells ● Stem Cells in Cardiovascular Research ● Stem Cells in Neuroscience ● Stem Cells in Internal Organs Research ● Stem Cells in Skin and Derivatives Research ● Stem Cells in Bone and Cartilage Research ● Stem Cells in Reproduction ● Stem Cells in Cancer Research ● Bioinformatics in Stem Cell Research 2. Stem Cells and Regenerative Medicine Join the Congress and benefit from expanding your network. Meet new friends, greet old colleagues and discuss new insight gained. We wish you a fruitful and enjoyable congress and looking forward to welcoming you to Tehran. Sara Pahlevan, Ph.D. Congress Chairperson th 14 Congress on Stem Cell Biology & Technology 5 14th Congress on Stem Cell Biology and Technology (29-31 August 2018, Terhran, Iran) Invited Speakers Is-1: Myeloid Lineage Cell during Healing: Friend or Foe? adhesives, as well as the in-situ fabrication of spatially organ- ized biomaterials, tissues, and biohybrid structures. Amini Nik S Is-3: Corneal Regeneration Department of Laboratory Medicine and Pathobiology, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Baradaran-Rafii A Email: [email protected] Cornea and Refractive Surgery Service, Labafinejad Medical Cent- Background: Inflammation, following skin injury, initiates a er, Shahid Beheshti University of Medical Sciences, Tehran, Iran series of autocrine and paracrine signals as well as a fine-tuned Email: [email protected] cellular interplay. Myeloid cells are one of the leading players in this orchestrated phenomenon. Limbal stem cells (LSCs) are regenerative engine for continu- Materials and Methods: Using in vitro and in vivo models of ous corneal epithelialization. Destruction of these stem cells or injuries, we highlight the contribution of myeloid cells as well their dysfunctional niche will lead to limbal stem cell deficiency as their fate during skin healing. We evaluate this role in differ- (LSCD). Limbal stem cell transplantation (LSCT) is the defini- ent models of healings, including deficient and excessive heal- tive treatment for LSCD. In unilateral cases, Conjunctival-Lim- ing. bal autograft transplantation (CLAU) and Cultivated Limbal Results: While myeloid cells show an essential role in normal Epithelial Transplantation (CLET) are the classical modali- skin healing, disturbed myeloid cells contribute to the deficient ties. In bilateral cases, Keratolimbal Allograft Transplantation healing of aged animals. Conversely, the augmented and sus- (KLAL), Living-Related Conjunctival-Limbal Allograft Trans- tained function of myeloid cells contributes to excessive heal- plantation (Lr- CLAL) and Cultivated Oral Mucosal Epithelial ing, leading to scar formation. Transplantation (COMET) are surgical alternatives. In a recent Conclusions: These works introduce a paradigm in which my- publication, we showed that in vivo cultivation of LSCs using eloid cells are recognized as the significant player in granula- amniotic membrane as a niche and amniotic membrane extract tion tissue formation and skin healing. eye drop (AMEED) as a promoting factor is a good surgical al- ternative in the case of unilateral LSCD. Now, in bilateral cases Is-2: 3D Skin Printing: In-Situ Formation of Planar Tissues we are working on in vivo cultivation of oral mucosal epithelial cells using amniotic membrane transplantation and AMEED. Amini Nik S Also, we are working on in vivo cultivation of LSCs using E- PRP drops. Our preliminary results are promising. Department of Laboratory Medicine and Pathobiology, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Is-4: Two-Way Conversion between Lipogenic and Myo- Email: [email protected] genic Fibroblastic Phenotypes Marks The Progression and Resolution of Lung Fibrosis Background: Wound healing and coverage
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