Product datasheet Anti-PDIA3 Antibody Catalog Number: M01464-1

BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

Basic Information Product Name Anti-PDIA3 Antibody Gene Name PDIA3 Source Mouse Species Reactivity mouse,rat Tested Application IP, IF, IHC, WB Contents Antibody concentration: 1 mg/ml, stored in PBS pH7.4, 50% glycerol, 0.09% sodium azide Immunogen Human recombinant ERp57 (Grp58) Purification Protein G Purified Observed MW Dilution Ratios WB (1:2000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Storage 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing

Background Information PDIA3 (Protein isomerase family A, member 3), also called GRP58, Erp57 or ER60, is an isomerase enzyme. It is mapped on 15q15.3. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex, which is essential for formation of the final antigen conformation and export from the to the cell surface. This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones and to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

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FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE. 1 Product datasheet Anti-PDIA3 Antibody Catalog Number: M01464-1

BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

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FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE. 2

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