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Generate Metabolic Map Poster Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000013645Cyc: Paraburkholderia xenovorans LB400 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino a dicarboxylate (2-aminoethyl) O-acetyl-L-serine phosphate phosphate acid acid acid acid acid acid acid acid acid acid acid acid acid acid an amino an amino molybdate molybdate glutathione phosphonate 4-amino-2-methyl-5- cys phosphate an amino an amino an amino an amino an amino an amino acid an amino an amino acid shikimate ethanolamine phosphate phosphate ammonium ammonium pyrimidinemethanol D-gluconate acid acid acid acid acid acid acid acid predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC transporter of RS04930 RS18170 RS25835 RS00080 RS36750 RS10120 RS01275 RS15630 RS01350 RS07775 RS40195 transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter RS09580 RS42135 RS33910 RS14575 RS15055 RS07310 RS26930 RS44965 RS01310 transporter transporter transporter transporter transporter (2-aminoethyl) of an of an of an of an of an of an of an of an of an of an of an of an of an of an of molybdate of molybdate of glutathione of phosphate of phosphate phosphonate amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid O-acetyl-L-serine an amino 4-amino-2-methyl-5- phosphate cys shikimate ethanolamine D-gluconate ammonium ammonium an amino an amino an amino an amino an amino an amino acid an amino an amino an amino pyrimidinemethanol phosphate phosphate (2-aminoethyl) acid acid acid acid acid acid acid acid acid molybdate molybdate glutathione phosphate phosphate phosphonate an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino a dicarboxylate acid acid acid acid acid acid acid acid acid acid acid acid acid acid Cofactor, Carrier, and Vitamin Biosynthesis Hormone Biosynthesis Other Biosynthesis Aldehyde Degradation Storage Compound Biosynthesis Inorganic Nutrient Metabolism Degradation/Utilization/Assimilation - Other N 6 -(3-methylbut- a methylated an O 4 - L-alanyl-γ-D- L-alanyl-γ-D- (2S)- a [protein]-L- queuosine at a D-5- an [amino-group a sulfurated a [protein]- UDP-N-acetyl- a lipid II 4-hydroxy- an L-asparaginyl- cob(II)yrinate a,c- flavin biosynthesis I (bacteria and plants) indole-3-acetate 8-amino-7- (aminomethyl)phosphonate degradation methylglyoxal degradation I 2-en-1-yl)- adenosylcobinamide a purine 2-oxoglutarate nucleobase methylthymine glutamyl-meso-2,6- glutamyl-meso- UDP-N-acetyl- α methylsuccinyl- a type IV prepilin L-threo-3-phenylserine glutamate-O 5 glu position 34 monosubstituted carrier protein]- predicted cob(II)yrinate a,c-diamide [2Fe-2S] iron-sulfur acyl carrier ubiquinol-8 biosynthesis superpathway of tetrahydrofolate biosynthesis dipyrromethane guanylyl molybdenum NAD superpathway of pyridoxal 5'-phosphate biosynthesis and salvage S-adenosyl-L-methionine salvage II polyhydroxybutanoate biosynthesis Fermentation mixed acid fermentation two-component alkanesulfonate monooxygenase L-cysteine -D-muramoyl- acetyl-CoA ATP roseoflavin Asn glyphosate degradation III methylphosphonate dimethyl sulfide assimilatory 2-aminoethylphosphonate sulfoacetaldehyde degradation I [sulfur carrier] 37 L-threonine [tRNA ] diamide biosynthesis I biosynthesis oxononanoate selenate reduction octane oxidation adenosine ribonucleoside within DNA in DNA diaminopimeloyl- UDP-N-acetyl- diaminopimelate α-D-muramate L-alanyl-γ-D- CoA -methyl-ester of a tRNA Asp hydantoin C-terminal-γ- ABC biosynthesis II (late cluster biosynthesis protein activation (early decarboxylation) cofactor biosynthesis cofactor biosynthesis phosphorylation and degradation I sulfate reduction III degradation I Asp/Glu/ 5'-phosphate sulfate sulfate (early cobalt insertion) IV (bacteria) biosynthesis III degradation acrylonitrile in tRNA 5'-triphosphate D-alanine α-D-muramate (L-glutamate 5- transporter cobalt incorporation) all-trans- MoO - transhydrogenation D-erythrose (aminomethyl)phosphonate methylglyoxal glutamyl-meso-2,6- penicillin- hydantoin an apo-[hydroxymethylbilane 2 SAH acetyl-CoA (indole-3-yl) phosphoenolpyruvate glyphosate II (oxidation) an alkylsulfonate FMNH degradation I uroporphyrinogen-III an apo acyl- GTP 4-phosphate selenate 2 (2-aminoethyl) sulfoacetaldehyde lactoylglutathione alpha- methylated-DNA-- diaminopimeloyl- semialdehyde-2-N-acetyl- of sulfate uroporphyrinogen-III L-cysteine desulfurase octaprenyl GTP synthase]-L-cysteine molybdopterin NAD + pimelate methylphosphonate sulfate NADH UDP-N- binding 3-oxoadipyl- prepilin low-specificity low specificity chemotaxis tRNA glutamyl- racemase: aminoacyl- carrier protein 4-hydroxybenzoate acetonitrile phosphonate dimethyl sulfide phosphonate tRNA (N6-isopentenyl bifunctional ketoglutarate- [protein]-cysteine S- bifunctional yl)-L-glutamategamma- uroporphyrinogen-III holo-ACP diphosphate cofactor molybdenum cofactor adenosylhomocysteinase: acetyl-CoA C- CoA ligase: phosphonate sulfate sulfate 2-aminoethylphosphonate lyase: UDP-N- acetylmuramate:L- D-alanyl-D-alanine protein CoA peptidase: L-threonine L-threonine response Q(34) BXE_RS40225 tRNA uroporphyrinogen-III ATP-NAD kinase: C-P lyase acrylonitrile adenosine(37)-C2)- adenosylcobinamide glutamyl- C-methyltransferase: BXE_RS20990 acyltransferase: phosphoenolpyruvate pyruvate kinase: pyk adenylyltransferase adenylyltransferase aminotransferase: sulfoacetaldehyde BXE_RS21980 dependent methyltransferase: acetylmuramate:L- alanyl-gamma-D- thiolase: BXE_RS08090 aldolase: ltaE aldolase: regulator protein- synthetase riboflavin hydrolase: sulfate RS00975 sulfate C-methyltransferase: cysteine synthase: GTP GTP cyclohydrolase I guanylyltransferase BXE_RS35295 BXE_RS39355 (acetamidomethyl)phosphonate C-P lyase kinase/ 2: mrdA Asp/Glu/ cobA 4-hydroxybenzoate a [hydroxymethylbilane guanylyl (indol-3-yl) carboxylase: ppc system protein subunit CysD: cysD methylthiotransferase dioxygenase BXE_RS18150 kinase/FAD phosphate cobA desulfurase: BXE_RS16510 cyclohydrolase FolE2: BXE_RS23070 MobA: mobA L-homocysteine BXE_RS10735 pimeloyl-CoA system protein subunit CysD: cysD BXE_RS26025 acetyltransferase: xsc [+ 3 isozymes] alanyl-gamma-D- glutamyl- meso- penicillin- pcaF prepilin low specificity BXE_RS15400 glutamate GluQRS: hydantoin pth an [amino-group a holo acyl- synthase] ES intermediate NAD kinase: 4-phospho- acetamide PhnL: phnL (R)-S- MiaB: miaB adenosylcobinamide- AlkB: D-alanyl-D-alanine synthetase: reductase: [+ 3 isozymes] BXE_RS29805 II: ribA octaprenyltransferase: 2 molybdenum [+ 8 isozymes] phosphonate C- PhnL: phnL dimethyl sulfoxide sulfate sulfate [+ 2 isozymes] methylated-DNA-- glutamyl- meso- diaminopimelate binding 3-oxoadipyl- peptidase: L-threonine low- methylesterase: BXE_RS05635 [+ 3 isozymes] carrier protein GTP cyclohydrolase BXE_RS02475 D-erythronate pyruvate α [+ 2 isozymes] a reduced acrylamide lactoylglutathione phosphate carboxypeptidase/ racemase: aminoacyl- carrier protein]-argC precorrin-1 ubiA hydroxymethylbilane cofactor + -D-ribose-1-[N- succinate BXE_RS27845 [protein]-cysteine S- BXE_RS17860 precorrin-1 [+ 3 isozymes] NADP 5-methyltetrahydropteroyltriglutamate- amidase: 8-amino-7- oxaloacetate P lyase system α [+ 2 isozymes] adenylyltransferase: adenylyltransferase: phosphonoacetaldehyde diaminopimelate ligase: mpl protein CoA BXE_RS19350 aldolase: specificity BXE_RS21250 BXE_RS40250 tRNA C-terminal-γ- sulfate RS12140 sulfate bifunctional I FolE: folE -D-ribose-1- acetyl phosphate sulfite octane rubredoxin dehydrogenase, guanylyltransferase: D-alanyl-D-alanine- an L-5- synthase: hemC - homocysteine S- acetoacetyl-CoA BXE_RS11550 oxononanoate protein PhnL: phnL (phosphonomethyl) BXE_RS03850 hydroxyacylglutathione alpha- methyltransferase: ligase: mpl 2: mrdA thiolase: BXE_RS15400 L-threonine uroporphyrinogen-III an S-sulfanyl-[L- 3,4-dihydroxy- methylphosphonate- adenosine 5'- BXE_RS03850 amidase: cobU endopeptidase: dacB glutamyl- monosubstituted hydrolase: (5-phospho- uroporphyrinogen-III 4-hydroxy-3- NAD(P) methyltransferase: metE [+ 9 isozymes] synthase: bioF D-lactate glycine] 5-triphosphate FMNH2-dependent phosphonoacetaldehyde hydrolase: gloB hydrophobic ketoglutarate- BXE_RS34125 roseoflavin C-methyltransferase: 2-butanone- 7,8-dihydroneopterin 3'-triphosphate a [hydroxymethylbilane [+ 2 isozymes] 5-triphosphate phosphoselenate APS BXE_RS11550 UDP-N-acetyl- D-alanyl-D-alanine pcaF aldolase: a [protein]-α- queuosine at hydantoin arfB L-glutamyl)- C-methyltransferase: cysteine desulfurase] octaprenylbenzoate (3R)-3-hydroxy-2-oxo-
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