<<

4\OZgaWa ]T bVS STTWQOQg ]T O[W\]^VS\gZO[WRW\Sa O\R QgQZ]]QbORS^aW^S^bWRSa O\R bVSW` []RS ]T OQbW]\

DgZn`nkZe(?bll^kmZmbhg

mh h[mZbg ma^ Z\Z]^fb\ ]^`k^^

?h\mhk h_ IZmnkZe N\b^g\^l

#?k) k^k) gZm)$

ln[fbmm^] mh ma^ ?^iZkmf^gm h_ =bheh`r' >a^fblmkr Zg] KaZkfZ\r

h_ Ak^b^ Pgbo^klbmum =^kebg

[r

7O\WSZ >cZYS

_khf G^o^kdnl^g

-+,/

Oabl phkd pZl ik^iZk^] _khf , lm h_ Zk^

,lm M^ob^p^k5 C`]T& 7`& :S]`U d]\ FO[a]\%;W[[SZabXS`\O Dglmbmnm^ h_ KZkZlbmheh`r Zg] Okhib\Ze Q^m^kbgZkr H^]b\bg^ ?^iZkmf^gm h_ Q^m^kbgZkr H^]b\bg^ Ak^b^ Pgbo^klbmum =^kebg B^kfZgr

-g] M^ob^p^k5 C`]T& 7`& ;O\a%=]OQVW[ CTZjUS` I^nkh[bheh`r Dglmbmnm^ h_ =bheh`r ?^iZkmf^gm h_ =bheh`r' >a^fblmkr Zg] KaZkfZ\r Ak^b^ Pgbo^klbmum =^kebg B^kfZgr

?Zm^ h_ ]^_^g\^5 Eng^ -+ ma -+,/

9KOTKX 4GSOROK

4QY\]eZSRUS[S\ba

Abklm h_ Zee' D phne] ebd^ mh maZgd fr lni^koblhk Kkh_) ?k) B^hk` ohg NZflhg(Cbff^elmc^kgZ Zg] fr \h(lni^koblhk K? ?k) E{k`^g Fk{\d^g _hk Ziikhobg` f^ Zl Z ]h\mhkZe \Zg]b]Zm^' _hk ma^bk bg]^_Zmb`Z[e^ lniihkm Zg] ma^bk \hglmZgm pbeebg`g^ll mh ]bl\nll i^kli^\mbo^l h_ fr ikhc^\m Zm Zee mbf^l makhn`ahnm ma^ iZlm r^Zkl) Dm pZl Z _ZgmZlmb\ i^kbh] h_ fr eb_^ Zg] D Z[lhenm^er ^gchr^] [^bg` Z iZkm h_ ma^ iZkZlbmheh`r `khni)

D phne] ebd^ mh maZgd Kkh_) ?k) CZgl EhZ\abf K_e{`^k _hk Z`k^^bg` mh k^ob^p fr ma^lbl)

Q^kr li^\bZe maZgdl `h mh ma^ pahe^ =Zr^k akblmbgZ H^km^gl Zg] ?k) >eZn]bZ R^es) Rbmahnm ma^bk f^gmZe Zg] _bgZg\bZe lniihkm Zg] ma^bk iZmb^g\^ pbma f^' ma^ ikhc^\m phne] g^o^k aZo^ k^Z\a^] bml ]bf^glbhg)

D hp^ Z ehm h_ mabl phkd mh fZgr `k^Zm l\b^gmblml Zkhng] ma^ phke]5

D phne] ebd^ mh maZgd Kkh_) ?k) C^bgs H^aeahkg Zg] ?k) B{gma^k N\afZae _hk ma^bk ^q\^ee^gm m^Z\abg` bg \eZllb\Ze iZkZlbmheh`r Ö bm pZl rhn fZdbg` a^efbgmaheh`r Zg bfihkmZgm iZkm h_ fr eb_^)

OaZgdl mh Kkh_) ?k) Mhe_ @gms^khma _hk ma^ lniihkm bg ^e^\mkhg fb\khl\hir)

HZgr maZgdl mh ?k) Nbfhg Ohpglhg _hk ma^ ng_hk`^mmZ[e^ ^qi^kb^g\^ h_ \hee^\mbg` ;TINUIKXIG M[ZZ[XUYG bg =Zgcne' ma^ BZf[bZ)

D Zf `kZm^_ne mh Kkh_) Gbg]r Che]^g(?r^' ?k) DmZ JÅF^eer Zg] ?k) kbl_hk] Zl p^ee Zl mh ?k) Pekb\a @[[bg`aZnl(Fbgml\a^k' ?k) ?bkd I^gglmb^e Zg] MheZg] Fngs^ _hk ma^bk _ZgmZlmb\ ZllblmZg\^ pbma fr ^e^\mkhiarlbheh`b\Ze ^qi^kbf^gml)

=b` maZgdl mh Kkh_) ?k) Obfhmar B^Zkr' Kkh_) ?k) Mh`^k Kkb\aZk]' Kkh_) ?k) Mh[bg =^^\a' >kblmbgZ =Zee^lm^khl' QZg^llZ ?n_hnk Zg] OahfZl ?n`n^m Zg] ma^ pahe^ iZkZlbmheh`r `khni Zm H\Bbee Pgbo^klbmr Ö rhn fZ]^ fr lmZr bg HhgmkvZe ng_hk`^mmZ[e^ ^o^g mahn`a fr ^qi^kbf^gml p^k^gÅm mhh ln\\^ll_ne)

OaZgdl mh Kkh_) ?k) <]kbZg Rhelm^gahef^ _hk ma^ 0X[MOG SGRG_O Zg] 2OXULORGXOG OSSOZOY fZm^kbZe Zg] Zee ma^ oZenZ[e^ ]bl\nllbhgl)

Ni^\bZe maZgdl mh Kkh_) ?k) E^ggb_^k F^bl^k Zg] ?k) Gn\b^gg^ Okbmm^g _hk ma^ mk^f^g]hnler bfihkmZgm ^q\aZg`^ h_ dghpe^]`^ Zg] ikh]n\mbo^ ]bl\nllbhgl ]nkbg` ma^ ^lmZ[eblaf^gm h_ iZkZlbm^ eb_^ \r\e^l Zg] ma^ OT \O\U l\k^^gl)

D Zelh pZgm mh ihbgm hnm Z `khni h_ i^hie^' pab\a fZ]^ ma^ eZlm r^Zkl lh ^gchrZ[e^) Oa^ pahe^ ÜKNá m^Zf' NZ[kbgZ MZf{gd^ Zg] Ghnbl^ G^=^e bg =^kebg Zl p^ee Zl fZgr i^hie^ Zm =Zr^k Zklm^g

GZlm [nm ghm e^Zlm' D phne] ebd^ mh ^qik^ll fr ]^^i^lm `kZm^_neg^ll mh fr _bZg\v' fr iZk^gml' fr lblm^k' fr `kZg]fhma^k #M)D)K)$ Zg] fr _kb^g]l) Thn lniihkm^] f^ bg Zee [^ehg`bg`l ( ^o^g b_ bm p^k^ phkfl bg ma^ _kb]`^ !

?^\eZkZmbhg hg ieZ`bZkblf5

D a^k^[r \hg_bkf maZm D aZo^ bg]^i^g]^gmer \hfihl^] mabl ma^lbl Zg] maZm hma^k maZg ma^ bg]b\Zm^] Zb] Zg] lhnk\^l aZo^ [^^g nl^]) Oabl phkd aZl ghm [^^g ik^l^gm^] mh Zgr hma^k ^qZfbgZmbhg [hZk])

=^kebg'

?Zgb^e Fned^

GOPZS ]T Q]\bS\ba

) :S\S`OZ W\b`]RcQbW]\ &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&)1 ,), Cblmhkb\Ze \hgm^fieZmbhg hg ma^ ]bo^klbmr h_ iZkZlbmb\ a^efbgmal )))))))))))))))))))))))))))))))))))))))))-+ ,)- I^fZmh]^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-- ,)-), >eZllb_b\Zmbhg h_ g^fZmh]^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-- ,)-)- B^g^kZe Jk`ZgblZmbhg h_ g^fZmh]^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-. ,)-). I^nkhfnl\neZk hk`ZgblZmbhg h_ g^fZmh]^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-/ ,)-)/ M^e^oZg\^ h_ g^fZmh]^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-2 ,)-)/), DfiZ\m hg ZgbfZe a^Zema )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) -3 ,)-)/)- DfiZ\m hg anfZg a^Zema )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) -4 ,). C^efbgma \hgmkhe ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))).+ ,).), >hgmkhe h_ ieZmra^efbgmal ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))).+ ,).),), KkZsbjnZgm^e )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) ., ,).)- >hgmkhe h_ g^fZmh]^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))).- ,).)-), ?b^mare\Zk[ZfZsbg^ )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) .. ,).)-)- Kbi^kZsbg^ ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) .. ,).)-). =^gsbfb]Zshe^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) ./ ,).)-)/ >ahebg^k`b\ ]kn`l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) ./ ,).)-)0 HZ\kh\r\eb\ eZ\mhg^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) .1 ,)/ M^lblmZg\^ )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))).2 ,)0 Anmnk^ \hgmkhe h_ g^fZmh]^ bg_^\mbhgl Ö g^p ]kn` \eZll^l ))))))))))))))))))))))))))))))))))))))))))))))))))).4 ,)0), r\ehh\mZ]^ilbi^imb]^ ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))/- ,)0). Nibkhbg]he^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))/1 ,)0)/

* "2 9/93 STTWQOQg ]T bVS O\bVSZ[W\bWQ b`WPS\RW[WRW\S OUOW\ab bVS QSab]RS !:1,230,4/6 1/+536731) W\ O Q]\b`]ZZSR ZOP]`Ob]`g b`WOZ &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&.1 -), <[lmkZ\m )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))2+ -)- Dgmkh]n\mbhg )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))2, -). HZm^kbZel Zg] f^mah]l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))20 -)/ M^lneml )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))22 -)0 ?bl\nllbhg )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))3+ -)1 >hg\enlbhgl )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))3. -)2 AbgZg\bZe lniihkm )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))3. -)3 >hg_eb\m h_ bgm^k^lm ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))3. -)4 M^_^k^g\^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))3/

+ "2 9/753 STTWQOQg ]T QgQZ]]QbORS^aW^S^bWRSa O\R O[W\]^VS\gZO[WRW\Sa OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab bVW`R%abOUS ZO`dOS O\R ORcZb e]`[a ]T #/44367532-:086 *5)6/0/,26/6 O\R TW`ab%abOUS ZO`dOS ]T '5/+./2,00) 64/5)0/6 &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&01 .), <[lmkZ\m )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))4+ .)- Dgmkh]n\mbhg )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))4, .). HZm^kbZel Zg] f^mah]l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))4. .)/ M^lneml )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))42 .)0 ?bl\nllbhg ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),+1 .)1 <\dghpe^]`^f^gml ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),+4 .)2 >hg_eb\m h_ bgm^k^lm )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),+4 .)3 M^_^k^g\^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),,+

, "2 9/93 STTWQOQg ]T C9)(**4 O\R \WQ]bW\WQ OQSbgZQV]ZW\S `SQS^b]` OU]\Waba OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab #/44367532-:086 *5)6/0/,26/6 &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&))- /), <[lmkZ\m ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),,1 /)- Dgmkh]n\mbhg ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),,2 /). HZm^kbZel Zg] f^mah]l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),,4 /)/ M^lneml ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),-. /)0 ?bl\nllbhg ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),.0 /)1 <\dghpe^]`^f^gml ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),.4 /)2 AbgZg\bZe lniihkm ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),.4 /)3 >hg_eb\m h_ bgm^k^lm )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),.4 /)4 M^_^k^g\^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),/+

- 8TTWQOQg ]T QgQZ]]QbORS^aW^S^bWRSa O\R O[W\]^VS\gZO[WRW\Sa OUOW\ab ZO`dOZ$ W[[Obc`S O\R [Obc`S ORcZb abOUSa ]T O ^O`OaWb]Z]UWQOZZg QVO`OQbS`WaSR b`WQVc`]aWa []RSZ W\ [WQS &&&&&&&&&&&),+ 0), <[lmkZ\m ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),// 0)-

. 6VO`OQbS`WaObW]\ ]T bVS QOZQWc[%UObSR O\R d]ZbOUS%RS^S\RS\b ^]bOaaWc[ QVO\\SZ F?B%) ]T

\S[Ob]RSa O\R Wba W\bS`OQbW]\ eWbV S[]RS^aWRS &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&)/1 1), <[lmkZ\m ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),3+ 1)- Dgmkh]n\mbhg ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),3, 1). HZm^kbZe Zg] f^mah]l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),3/ 1)/ M^lneml ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),4+ 1)0 ?bl\nllbhg )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-+. 1)1 M^_^k^g\^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-+3 1)2 Nniihkmbg` bg_hkfZmbhg )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-,2

/ 6][^`SVS\aWdS RWaQcaaW]\ &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&**+ 2), @oZenZmbhg h_ \^lmh]b\b]Ze OT \O\U ^__b\Z\r h_ Zfbghia^greZfb]bg^l )))))))))))))))))))))))))))))))))--0 2)- @oZenZmbhg h_ g^fZmb\b]Ze OT \OZXU ^__b\Z\r )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))--1 2). @oZenZmbhg h_ g^fZmb\b]Ze OT \O\U ^__b\Z\r Z`Zbglm :# HXGYOROKTYOY )))))))))))))))))))))))))))))))))))))--2 2)/ @oZenZmbhg h_ g^fZmb\b]Ze OT \O\U ^__b\Z\r Z`Zbglm ?# S[XOY )))))))))))))))))))))))))))))))))))))))))))))))--3 2)0 Dgo^lmb`Zmbhgl hg ma^ OT \O\U iaZkfZ\hdbg^mb\l h_ Zfbghia^greZfb]bg^l bg kZml )))))))))))))))--4 2)1 Dgo^lmb`Zmbhgl hg ma^ fh]^ h_ Z\mbhg h_ Zgma^efbgmb\l [r ^e^\mkhg fb\khl\hir )))))))))))))))))-.+ 2)2 Dgo^lmb`Zmbhgl hg ma^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l [r a^m^kheh`hnl ^qik^llbhg h_ ihm^gmbZe mZk`^m `^g^l bg C# RGK\OY hh\rm^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-., 2)3 @oZenZmbhg h_ Zfbghia^greZfb]bg^l Zl [khZ](li^\mknf Zgma^efbgmb\l ))))))))))))))))))))))))))))))-.- 2)4 @oZenZmbhg h_ \r\ehh\mZ]^ilbi^imb]^l Zl ^qm^g]^] [khZ](li^\mknf Zgma^efbgmb\l ))))))))))))-.1 2),+ @oZenZmbhg h_ ]kn` \hf[bgZmbhgl Zl [khZ](li^\mknf Zgma^efbgmb\l )))))))))))))))))))))))))))))))))))-/+ 2),, NnffZkr Zg] hnmehhd )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-/- 2),- M^_^k^g\^l )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-//

0 Fc[[O`g' LcaO[[S\TOaac\U &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&*-+ 3), NnffZkr )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-0/ 3)- UnlZff^g_Zllng` )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-01

1 ?Wab ]T ^cPZWQObW]\a &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&*-1

)( 6c``WQcZc[ dWbOS &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&*.-

)) 4^^S\RWQSa &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&*/)

?Wab ]T TWUc`Sa

Ab`) ,(,) I^nkhfnl\neZk hk`ZgblZmbhg h_ g^fZmh]^l ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) -0 Ab`) ,(-) Hh]^e _hk ma^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l) ))))))))))))))))))))))))))))))))))))))))) /0 Ab`) -(,) Nmkn\mnk^ _hkfneZ h_ Zfb]Zgm^e' mkb[^g]bfb]bg^ Zg] ]hfiZkblhg h_ NGJ(, lieb\^ oZkbZgml bg g^fZmh]^l ))))))))))))))))))))))))))))))))))))))))))))))) ,4-

Ab`) 1(.) @lmbfZmbhg h_ lieb\^ oZkbZgm Z[ng]Zg\^l ^g\h]^] mkng\Zm^] hk _nee(e^g`ma o^klbhgl h_ ?# S[XOY NGJ(,),ÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑ,4. Ab`) 1(/) Ak^jn^g\b^l h_ ?# Y[OY leh(, lieb\^ oZkbZgml \hfiZkbg` ]^o^ehif^gmZe lmZ`^l' ]b__^k^gm l^q^l Zg] mblln^l))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),4/ Ab`) 1(0) Kareh`^g^mb\ ZgZerlbl h_ g^fZmh]^ NGJ(, \aZgg^el ))))))))))))))))))))))))))))))))))))))))))))))) ,43 Ab`) 1(1) >nkk^gml h[l^ko^] bg ohemZ`^(\eZfi ^qi^kbf^gml ))))))))))))))))))))))))))))))))))))))))))))))))))) -++ Ab`) 1(2) ?^m^kfbgZmbhg h_ ^fh]^ilb]^ ^__^\ml hg \nkk^gm ohemZ`^ \nko^l bg C# RGK\OY hh\rm^l bgc^\m^] pbma 1# KRKMGTY NGJ(,Z \MI<)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-+, Nniie^) Ab`) 1(3) >nkk^gml h[mZbg^] _khf ?# S[XOY leh(,),Z bgc^\m^] hh\rm^l )))))))))))))))))))))))) ---

?Wab ]T bOPZSa

OZ[) -(,) Kn[ebla^] mkb[^g]bfb]bg^ ]hlZ`^l Zg] \nk^ kZm^l ))))))))))))))))))))))))))))))))))))))))))))))))))))) 2/ OZ[) -(-) ?^lb`g Zg] hnm\hf^ h_ bg]bob]nZe ZgbfZe ^qi^kbf^gml ))))))))))))))))))))))))))))))))))))))))))) 23 OZ[) .(,) >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn` \hf[bgZmbhgl bg ma^ ?# YVOXGROY G, )))))))))))))))) 43 OZ[) .(-) >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn` \hf[bgZmbhgl bg ma^ :# HXGYOROKTYOY G. fhmbebmr ZllZr)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) ,+, OZ[) .(.) >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn`(\hf[bgZmbhgl bg ma^ :# HXGYOROKTYOY Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZrÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑÑ ,+/ OZ[) /(,) ?hl^l h_ ]kn` \hf[bgZmbhgl Z]fbgblm^k^] bg ma^ :# HXGYOROKTYOY OT \O\U ZllZr )))))) ,-+ OZ[) /(-) >hfiZkblhg h_ m^lm^] ]kn`l bg ma^ :# HXGYOROKTYOY OT \O\U ZllZr ))))))))))))))))))))))))))))) ,-0 OZ[) /(.) KeZlfZ iaZkfZ\hdbg^mb\ iZkZf^m^kl h_ ]^Z\reZm^] Zfb]Zgm^e Z_m^k hkZe mk^Zmf^gm pbma ]^Z\reZm^] Zfb]Zgm^e hk mkb[^g]bfb]bg^)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),./ OZ[) 0(,) Nbg`e^ Zg] fnembie^ ]kn` ]hlZ`^l ^oZenZm^] OT \O\U Z`Zbglm fZmnk^ Z]neml h_ ?# S[XOY ' \eZllb_b^] [r khnm^ h_ Z]fbgblmkZmbhg))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),0- OZ[) 0(-) >hfiZkblhg h_ ma^ OT \O\U ^__b\Z\b^l h_ fhghma^kZib^l Z`Zbglm fZmnk^ Z]neml ?# S[XOY bg fb\^)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),1, Nniie^) OZ[) 0(.) Gh\ZeblZmbhg h_ ?# S[XOY lmZ`^l makhn`ahnm ik^iZm^g\r ))))))))))))))))))))))))))))) ,20 Nniie^) OZ[) 0(/) O^fi^kZmnk^ ]^i^g]^g\r h_ ?# S[XOY eZkoZe ]^o^ehif^gm bg ^``l )))))))))))) ,21 Nniie^) OZ[) 0(0) ?^l\kbimbo^ lmZmblmb\l _hk ^Z\a mk^Zmf^gm `khni)))))))))))))))))))))))))))))))))))))))))),22 OZ[) 1(,) M^eZmbo^ Z[ng]Zg\^ h_ \?I< Zfieb\hgl ^g\h]bg` _nee(e^g`ma hk mkng\Zm^] ?# S[XOY NGJ(, \aZgg^el)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))),4- Nniie^) OZ[) 1(-) ?^mZbel _hk NGJ(, \aZgg^e ikhm^bg l^jn^g\^l nlbg` _hk iareh`^g^mb\ ZgZerlbl Zg] b]^gmb_b\Zmbhg h_ lieb\^ oZkbZgml))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))-,2 Nniie^) OZ[) 1(.) Kkbf^k l^jn^g\^l' pab\a p^k^ nl^] mh Zfieb_r _nee(e^g`ma l^jn^g\^l h_ iZkZlbmb\ g^fZmh]^ leh(, \?I

?Wab ]T OPP`SdWObW]\a

0(CO )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) N^khmhgbg Ä )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) M^`blm^k^] mkZ]^fZkd aM )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) <\^mre\ahebg^ k^\^imhk <]

)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) ) )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) =^_hk^ >akblm -& V>Z Wb ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) bgmkZ\^eeneZk \Ze\bnf \hg\^gmkZmbhg >D ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) >hg_b]^g\^ bgm^koZel

>fZq )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) HZqbfZe ieZlfZ \hg\^gmkZmbhg ?

@> 0+ )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) @__^\mbo^ \hg\^gmkZmbhg #0+ $

@? 0+*4+*40*44 )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) @__^\mbo^ ]hl^ #0+ ' 4+ ' 40 ' 44 $ ^i` ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) @``l i^k `kZf @N lrlm^f ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) @q\k^mhkr(l^\k^mhkr lrlm^f AFKH )))))))))))))))))))))))))))))))))) AkZ`f^gml i^k dbeh[Zl^ h_ ^qhgl i^k fbeebhg _kZ`f^gml fZii^] B<=< ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) '(Zfbgh[nmrkb\ Z\b] Ben>e )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) BenmZfZm^ `Zm^] \aehkb]^ \aZgg^e O#K ) )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) OJ KYZ #maZm f^Zgl$ DQ> )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) >nkk^gm(ohemZ`^ \nko^ G, )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Abklm(lmZ`^ eZkoZ^ G- ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) N^\hg](lmZ`^ eZkoZ^ G. )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Oabk](lmZ`^ eZkoZ^ G/ )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Ahnkma(lmZ`^ eZkoZ^ G

G? 0+*44 ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) G^maZe ]hl^ #0+ ' 44 $ GA ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) GrfiaZmb\ _beZkbhlbl H?< )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) HZll ]kn` Z]fbgblmkZmbhg g<>aM ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Ib\hmbgb\ Z\^mre\ahebg^ k^\^imhk IAM )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) IhkfZe _kh` kbg`^k IID )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) I^Zk^lm g^b`a[hnk bgm^k\aZg`^ IJ ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Ibmkb\ hqb]^ JOP )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Ji^kZmbhgZe mZqhghfb\ ngbm KF> )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Kkhm^bg dbgZl^ > iif ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) KZkml i^k fbeebhg V#O# ################################################################################################################## h^__b\b^gml h_ ]^m^kfbgZmbhg M>F )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) M^`neZmhk h_ \hg]n\mbhg h_ ihmZllbnf #MO($K>M ))))))))))))))))))))))))))))))))))))))))))))))))) #M^o^kl^ mkZgl\kbimZl^$ iherf^kZl^ \aZbg k^Z\mbhg N? ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) NmZg]Zk] ]^obZmbhg N@H ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) NmZg]Zk] ^kkhk h_ ma^ f^Zg NIK ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Nbg`e^ gn\e^hmb]^ iherfhkiablf NKM ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Nn[mk^^ ikngbg` Zg] k^`kZ_mf^gm #NNP$ k?I< )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) #NfZee ln[ngbm$ kb[hlhfZe ?I< NOC ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) Nhbe(mkZglfbmm^] a^efbgmahlbl OK<> ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))) O^k^iaZeb\ Z\b] OK

6VO^bS` )

:S\S`OZ <\b`]RcQbW]\

1NGVZKX &

) :S\S`OZ W\b`]RcQbW]\

)&) ;Wab]`WQOZ Q]\bS[^ZObW]\ ]\ bVS RWdS`aWbg ]T ^O`OaWbWQ VSZ[W\bVa

b/Z ZNK GVVXUGIN UL JKTZOZOUT! VX[XOZ[Y UL ZNK M[SY! LK\KXY! IUT\[RYOUTY! JOGXXNKG! KYVKIOGRR_ ]NKT I[ZZOTM ZNK IGTOTK ZKKZNa ?U VKXYUTY YUSK]NGZ URJKX! GLLKIZOUTY UL ZNK ZUTYORY! OTI[X\GZOUT UL ZNK YVOTK GZ ZNK \KXZKHXG TK^Z ZNK UIIOV[Z! GYZNSG! IGRI[R[Y! XU[TJ ]UXSY ENKRSOTZNYF! GYIGXOJKY! GIXUINUXJUT! YGZ_XOGYS[Y! YZX[SG! GTJ UZNKX Z[HKXIRKY EVN_SGZGF! H[Z KYVKIOGRR_ ZNK GLUXKYGOJc #

Oa^ _bklm k^_^k^g\^ h_ li^\b_b\ mri^l h_ bgm^lmbgZe phkfl Zg] ]^l\kbimbhgl h_ Zgma^efbgmb\ ik^l\kbimbhgl bl ]Zm^] [Z\d Zkhng] ,00+ =)>) bg ma^ @[^kl KZirknl V-W) )$' bm aZl [^^g dghpg maZm ma^k^ bl fhk^ maZg hg^ mri^ h_ iZkZlbmb\ a^efbgmal ! ikbfZkber lmkbdbg` \abe]k^g kb`am Z_m^k m^^mabg` V,W) Dg ma^ Cbiih\kZmb\ >hkinl mak^^ mri^l h_ a^efbgmal Zk^ ]^l\kb[^]5 Ü NKRSOTY YZXUTM_RK á #khng]phkfl$' Ü NKRSOTY VRGZKOG á #_eZmphkfl$' Zg] Ü GYIGXOY á #pab\a \hkk^lihg]l mh 3TZKXUHO[Y \KXSOI[RGXOY $ V-W) =Zl^] hg ma^ Cbiih\kZmb\ ]h\mkbg^' )$ \hgmbgn^] pbma ma^ \Zm^`hkblZmbhg h_ ma^ mak^^ mri^l h_ bgm^lmbgZe phkfl V.W) Ankma^kfhk^' bglm^Z] h_ aZobg` k^ikh]n\mbhg' hglb]^k^] Zl Zg ^q\^imbhg'

b?NK LRGZ]UXS! NU]K\KX! OT GT K^IKVZOUTGR ]G_! IROTMY LGYZ ZU ZNK M[Z! GTJ RG_Y G ZNOTM ROQK G SKRUT"YKKJ! H_ UHYKX\OTM ]NOIN OTJOIGZOUT ZNK VN_YOIOGT IUTIR[JKY ZNGZ NOY VGZOKTZ OY ZXU[HRKJ ]OZN ZNK ]UXSc #CblmhkbZ ZgbfZebnf =hhd Q' KZkm ,4$ V.W

^elnl' Gn\bnl Engbnl Hh]^kZmnl >henf^eeZ Zg] <^ebnl BZe^gnl #,.+(-+1$ Zelh k^ihkm^] hg anfZg Zg] ZgbfZe bg_^\mbhgl pbma bgm^lmbgZe phkfl Zg] ma^ fhkiaheh`r h_ ma^l^ iZkZlbm^l V/W) Hhk^ho^k' Kn[ebnl AeZobnl Q^`^mbnl M^gZmnl #/0+(0,+$ Zg]

-+ 5KTKXGR 7TZXUJ[IZOUT

^qm^glbo^er f^gmbhg^] bg_^\mbhgl h_ i^ml Zg] anfZgl pbma bgm^lmbgZe phkfl Zg] ma^ ZiikhikbZm^ ma^kZir bg ma^bk pkbmbg`l' k^li^\mbo^er V/W) Oa^ Cbiih\kZmb\ \eZllb_b\Zmbhg Ö Ü GYIGXOY á Z__^\m ma^ eZk`^ bgm^lmbg^ Zg] Ü NKRSOTY YZXUTM_RKc ma^ lfZee bgm^lmbg^ Ö pZl \aZee^g`^] pbma ma^ bgmkh]n\mbhg h_ ma^ \eZllb_b\Zmbhg [r Gbggv #,203$ hger V/W) Nbg\^ Gbggv m^kf^] ma^ khng]phkfl h_ ma^ lfZee bgm^lmbg^ Zl Zl\Zkb]l Zg] ma^ khng]phkfl h_ ma^ eZk`^ bgm^lmbg^ lmkhg`reb]l' Z ehm h_ \hg_nlbhg \hg\^kgbg` ma^ \eZllb_b\Zmbhg h_ bgm^lmbgZe phkfl ^qblm^] V/W) Rbma ma^ in[eb\Zmbhg h_ ma^ pkbmbg` ÜQ^kln\a ^bg^k IZmnk`^l\ab\am^ ]^k @bg`^p^b]^p{kf^k mab^kbl\a^k Fzki^ká #,23-$' EhaZgg ^lmh]Z hk mZi^phkfl Zg] Ok^fZmh]Z hk _end^l) Nbg\^ ma^ oZkb^mr h_ li^\b^l bl maZm ]bo^kl^ Zg] fhlm li^\b^l Z]]k^ll^] bg mabl ma^lbl' [^ehg` mh ma^ I^fZmh]Z' hger mabl mZqhg pbee [^ bgmkh]n\^] bg ]^mZbe)

-, 1NGVZKX &

)&* AS[Ob]RSa

I^fZmh]^l Zk^ f^mZshZg hk`Zgblfl pbma Z \rebg]kb\Ze mh _beb_hkf [h]r laZi^ V2W) Rbma Zg ^lmbfZm^] +), Ö ,++ fbeebhg li^\b^l' ma^ mZqhg I^fZmh]Z bl \hglb]^k^] mh [^ hg^ h_ ma^ fhlm ]bo^kl^ mZqZ bg ma^ ZgbfZe dbg`]hf V3W) Ankma^kfhk^' _k^^(ebobg` g^fZmh]^l Zk^ hg^ h_ ma^ fhlm pb]^er ]blmkb[nm^] hk`Zgblfl bg fZkbg^' _k^lapZm^k Zg] m^kk^lmkbZe aZ[bmZml V4W) I^qm mh ma^ oZkb^mr h_ _k^^(ebobg` li^\b^l' iZkZlbmblf bl Z \hffhg eb_^ _hkf _hk Z eZk`^ gnf[^k h_ g^fZmh]^l) <\\hk]bg` mh Z iareh`^g^mb\ ZgZerlbl \hfiZkbg` lfZee ln[ngbm kb[hlhfZe ?I< #NNP k?I<$ l^jn^g\^l _khf Z pb]^ kZg`^ h_ g^fZmh]^l' =eZqm^k KZ GR# V,+W ln``^lm maZm ZgbfZe iZkZlbmblf Zkhl^ Zm e^Zlm _hnk mbf^l Zg] ieZgm iZkZlbmblf mak^^ mbf^l bg]^i^g]^gmer) ?^libm^ Z ]^\^imbo^er lbfie^ Zg] \hglblm^gm ZgZmhfb\Ze iZmm^kg' _Zl\bgZmbg` Z]Zimbhgl mh ma^bk ^gobkhgf^gml `Zo^ kbl^ mh Z \hfie^q Zg] [bheh`b\Zeer li^\bZebs^] `khni h_ f^mZshZgl V,,W) @o^g Z_m^k .0+ r^Zkl h_ lmn]b^l hg eb_^ \r\e^l Zg] k^eZmbhglabil h_ g^fZmh]^l' ma^ eZ\d h_ h[c^\mbo^ \kbm^kbZ _hk Zll^llbg` ahfheh`r h_ fhkiaheh`b\Ze \aZkZ\m^kl aZfi^kl ma^ k^\hglmkn\mbhg h_ ma^ iareh`^gr h_ g^fZmh]^l V3W)

,)-), >eZllb_b\Zmbhg h_ g^fZmh]^l

>abmphh] ! >abmphh] V,-W Zg] >abmphh] V,.',/W in[ebla^] lhf^ h_ ma^ ^Zkeb^lm Zg] fhlm bg_en^gmbZe \eZllb_b\Zmbhgl h_ g^fZmh]^l [r ]bob]bg` ma^ iarenf I^fZmh]Z bgmh ma^

N^jn^g\bg` h_ l^o^kZe \hfie^m^ ,3N k?I

,)-)- B^g^kZe Jk`ZgblZmbhg h_ g^fZmh]^l

Oa^ [Zlb\Zeer ngb_hkf ZgZmhfb\Ze iZmm^kg h_ g^fZmh]^l bl ]^l\kb[^] bg l^o^kZe in[eb\Zmbhgl V2',,',2',3W) I^fZmh]^l Zk^ [beZm^kZe lrff^mkb\Ze Zg] ngl^`f^gm^] hk`Zgblfl pbma Z \rebg]kb\Ze' phkf(ebd^ laZi^) Chp^o^k' g^fZmh]^l oZkr bg e^g`ma _khf fb\khl\hib\ lbs^l mh l^o^kZe f^m^kl bg e^g`ma) Ni^\b^l Zk^ `^g^kZeer [bl^qnZe pbma leb`am mh lmkbdbg` l^qnZe ]bfhkiablfl #_^fZe^l Zk^ fhlmer eZk`^k maZg fZe^l$) Oa^ [h]r pZee bl \hfihl^] h_ Z \aZkZ\m^kblmb\ Z\^eeneZk \nmb\ne^ pbma Zg ^ib]^kfbl #arih]^kfbl$ Zg] Z eZr^k h_ fnl\e^ \^eel eZrbg` [^g^Zma' _hkfbg` ma^ ^qhld^e^mhg) Oh`^ma^k pbma ma^ _enb](_bee^] [h]r \Zobmr' ma^ il^n]h\h^e' ma^ ar]khlmZmb\ ld^e^mhg bl _hkf^]) Oa^ Kl^n]h\h^e bg\ehl^l ma^ g^kohnl lrlm^f' ma^ ]b`^lmbo^ mkZ\m Zl p^ee Zl ma^ k^ikh]n\mbo^ lrlm^f) Oa^ ]b`^lmbo^ lrlm^f lmZkml \kZgbZe pbma ma^ [n\\Ze \Zobmr _heehp^] [r ma^ iaZkrgq' ma^ bgm^lmbg^ Zg] ma^ \Zn]Ze k^\mnf) Dg _^fZe^l Zg] eZkoZ^ ma^ ]b`^lmbo^ mkZ\m m^kfbgZm^l pbma Zg Zgnl' pa^k^Zl fZe^l aZo^ Z \ehZ\Z _hkf^] [r ma^ oZl ]^_^k^gl chbgbg` ma^ k^\mnf) I^fZmh]^l aZo^ Z \hfie^q g^kohnl lrlm^f) Oa^ g^ko^ kbg` ^g\bk\e^l ma^ iaZkrgq Zg] bl \hgg^\m^] mh ma^ Zgm^kbhk Zg] ihlm^kbhk obZ ehg`bmn]bgZe g^ko^l) Oa^ ]hklZe Zg] o^gmkZe g^ko^ \hk]l Zkbl^ _khf ma^ g^ko^ kbg` Zg] kng \Zn]Ze) N^o^kZe \hffbllnk^l \hgg^\m ma^ ehg`bmn]bgZe g^ko^l) Nn[f^]bZg g^ko^l Zk^ pbmahnm Z `Zg`ebhg' pa^k^Zl ma^ eZm^kZe g^ko^ \hgmZbgl Z _^p Zg] ma^ o^gmkZe g^ko^ Z \aZbg h_ `Zg`ebZ) >kZgbZe' lbq g^ko^l \hgg^\m ma^ g^ko^ kbg` mh ma^ \^iaZeb\ l^glhkr hk`Zgl #l^glbeeZ$) < l^glbeenf bl ^bma^k Z f^\aZghk^\^imhk hk aZl \a^fhl^glhkb\ _ng\mbhgl) I^qm mh ma^ \kZgbZe l^glbeeZ' Z gnf[^k h_ mZ\mbe^ iZibeeZ^ hk l^glhkr hk`Zgl \Zg [^ _hng] hg ma^ [h]r lnk_Z\^ bg\en]bg` Zfiab]l' \^kob\Ze iZibeeZ^' fZe^ \Zn]Ze iZibeeZ^' iaZlfb]l Zg] _^fZe^ i^kboneoZe ikh[^l #_hk k^ob^p h_ l^gl^ hk`Zgl' l^^ V,4W$) ?n^ mh ma^ bfihkmZg\^ bg ma^ fh]^ h_ Z\mbhg h_ l^o^kZe Zgma^efbgmb\ ]kn` \eZll^l' fhk^ ]^mZbel hg ma^ g^nkhfnl\neZk hk`ZgblZmbhg Zg] ma^ bgoheo^f^gm bg ma^ -. 1NGVZKX & lm^k^hmrib\ ]hklho^gmkZe lbgnlhb]Ze [h]r fho^f^gm pbee [^ `bo^g bg ma^ _heehpbg` \aZim^k) Oa^ _^fZe^ k^ikh]n\mbo^ mkZ\m \hglblml fhlmer h_ iZbk^] hoZkb^l \hgg^\m^] mh ma^ nm^knl obZ ma^ hob]n\m' ma^ m^kfbgZe oneoZ Zg] ma^ k^\^imZ\nenf l^fbgbl) Oa^ k^ikh]n\mbo^ lrlm^f h_ fZe^ g^fZmh]^l \hglblml h_ ma^ m^lm^l Zg] ma^ l^fbgZe `eZg] \hgg^\m^] obZ ma^ oZl ]^_^k^gl) HZe^ phkfl fZr Zelh aZo^ Z li^\b^l(li^\b_b\ [nklZ \hineZmkbq Zg] iZbk^] lib\ne^l) I^fZmh]^l aZo^ Zg ^q\k^mhkr(l^\k^mhkr #@N$ lrlm^f [nm gh \bk\neZmhkr lrlm^f) ?nkbg` ma^ ]^o^ehif^gm _khf ^`` mh Z]nem phkfl' g^fZmh]^l ng]^k`h _hnk fhneml #_khf _bklm(lmZ`^ #G,$ mh l^\hg](lmZ`^ #G-$ mh mabk](lmZ`^ #G.$ mh _hnkma(lmZ`^ #G/$ eZkoZ^ mh ik^Z]nem phkfl$ [r \hfie^m^er la^]]bg` ma^ \nmb\ne^ ^Z\a mbf^' _heehp^] [r ma^ ]^o^ehif^gm h_ l^qnZe fZmnkbmr #fZmnk^ Z]nem$) Gb_^ \r\e^l Zk^ o^kr ]bo^kl^ Zg] \aZkZ\m^kblmb\ _hk lrlm^fZmb\Ze `khnil pbmabg ma^ iarenf I^fZmh]Z' bg\en]bg` lmZ`^(li^\b_b\ iZkZlbmblf \hf[bg^] pbma _k^^(ebobg` lmZ`^l Zl p^ee Zl iZkZlbmblf makhn`ahnm Zee eb_^ \r\e^ lmZ`^l # K#M# ?XOINOTKRRG YVOXGROY $)

,)-). I^nkhfnl\neZk hk`ZgblZmbhg h_ g^fZmh]^l

Dg hk]^k mh ng]^klmZg] ma^ fh]^ h_ Z\mbhg h_ l^o^kZe Zgma^efbgmb\l' ikh_hng] dghpe^]`^ h_ ma^ hk`ZgblZmbhg h_ g^fZmh]^ g^nkhfnl\neZk mkZglfbllbhg bl ^ll^gmbZe) Oa^k^_hk^' ma^ hk`ZgblZmbhg h_ g^fZmh]^ g^nkhZgZmhfr' lhfZmb\ fnl\e^ \^eel Zl p^ee Zl g^nkhfnl\neZk lb`gZe mkZglfbllbhg Zk^ ]^l\kb[^] #Z\\hk]bg` mh V-+W$) Oa^ g^kohnl lrlm^fl h_ /YIGXOY Y[[S Zg] 1# KRKMGTY p^k^ ]^l\kb[^] mh \hglblm h_ ZiikhqbfZm^er -0+ Zg] .-+ g^nkhgl' k^li^\mbo^er) @Z\a g^fZmh]^ g^nkhg \Zg aZo^ [^mp^^g hg^ Zg] .+ ]b__^k^gm lrgZimb\ \hgmZ\ml' k^lnembg` bg Z mhmZe h_ ZiikhqbfZm^er 0+++ \a^fb\Ze lrgZil^l' 1++ `Zi cng\mbhgl Zg] -+++ g^nkhfnl\neZk cng\mbhgl V-+W) Gh\hfhmbhg bl \hgmkhee^] [r ma^ fhmhk g^kohnl lrlm^f #^q\en]^l ma^ g^ko^ kbg` Zg] ma^ \kZgbZe g^nkhgZe g^mphkd$' \hglblmbg` h_ _bo^ k^i^Zm^] l^`f^gml pbma ^e^o^g fhmhg^nkhgl' ^Z\a) =Zl^] hg ma^bk fhkiaheh`r #]blmkb[nmbhg h_ ma^bk Zqhgl Zg] ]^g]kbm^l$ ma^l^ g^nkhgl Zk^ \eZllb_b^] bgmh l^o^g mri^l #Q,' QD' Q-' ?,' ?@,' ?@- Zg] ?@.$) ?,' ?@- Zg] ?@. Zk^ ik^l^gm hg\^' pa^k^Zl ma^ k^fZbgbg` mri^l h\\nk mpb\^ bg ^Z\a h_ ma^ l^`f^gml #l^^ Ab`) ,(,<$) ?, Zg] QD Zk^ bgab[bmhkr fhmhg^nkhgl' pa^k^Zl ?@D' ?-' ?.' Q,' Q- Zg] Q. Zk^ ^q\bmZmhkr fhmhg^nkhgl V-+W) I^qm mh cng\mbhgl mh bgm^kg^nkhgl Zl p^ee Zl lrgZimb\ \hgmZ\ml mh hma^k fhmhg^nkhgl' ma^r aZo^ g^nkhfnl\neZk \hgg^\mbhgl pbma lhfZmb\ fnl\e^ \^eel) Oa^ ehg`bmn]bgZe hkb^gm^]' libg]e^(laZi^] lhfZmb\ fnl\e^ \^eel Zk^ _hng] `khni^] bg jnZkmbe^l [^mp^^g ma^ arih]^kfZe \hk]l #o^gmkZe Zg] ]hklZe g^ko^ \hk]' Zg] eZm^kZe \hk]l \hgmZbgbg` g^ko^l Zg] ma^ C \^ee \hglmbmnmbg` ma^ ^q\k^mhkr lrlm^f$) Oa^ \khll(l^\mbhg h_ g^fZmh]^l \Zg -/ 5KTKXGR 7TZXUJ[IZOUT ma^k^_hk^ [^ ]bob]^] bgmh _hnk iZkml #l^^ Ab`) ,(,=$) @Z\a lhfZmb\ fnl\e^ \^ee #l^^ Ab`) ,(,>$ bl h_ ma^ h[ebjn^er lmkbZm^] fnl\e^ \^ee mri^) Oa^ \hgmkZ\mbe^ iZkm \hgmZbgl mabg Zg] mab\d _beZf^gml ZkkZg`^] bg Z p^ee(]^_bg^] Zg`e^' Zeehpbg` ma^ fnl\e^ mh ab`aer ^qm^g] pabe^ fZbgmZbgbg` ma^ o^eh\bmr h_ \hgmkZ\mbhg) Oa^ ghg(\hgmkZ\mbe^ ihkmbhg \hgmZbgl ma^ \^ee gn\e^nl)

9WU& )%)& I^nkhfnl\neZk hk`ZgblZmbhg h_ g^fZmh]^l #fh]b_b^] [r Mb\aZk] HZkmbg _khf V-+W$ <$ N\a^fZmb\ beenlmkZmbhg h_ hg^ h_ ma^ _bo^ k^i^Zm^] l^`f^gml h_ ma^ fhmhk g^kohnl lrlm^f \hgmkheebg` eh\hfhmbhg) Oa^ o^gmkZe Zg] ]hklZe g^ko^ \hk]l Zk^ \hgg^\m^] obZ _hnk \hffbllnk^l #mak^^ kb`am(aZg] Zg] hg^ e^_m(aZg]$) @Z\a \hffbllnk^ \hgmZbgl hg^ hk mph Zqhgl h_ fhmhg^nkhgl' pab\a aZl bml \^ee [h]r bg ma^ o^gmkZe g^ko^ \hk]) ?blmkb[nmbhg h_ ma^ ^e^o^g fhmhg^nkhgl Q, #-q ^q\bmZmhkr$' QD #-q bgab[bmhkr$' Q- #-q ^q\bmZmhkr$' ?@D #-q ^q\bmZmhkr$' ?, #,q bgab[bmhkr$' ?- #,q ^q\bmZmhkr$ Zg] ?. #,q ^q\bmZmhkr$ bl Zelh lahpg) =$ DeenlmkZmbhg h_ ma^ \khll(l^\mbhg h_ Z g^fZmh]^' lahpbg` ma^ ]boblbhg h_ lhfZmb\ fnl\e^ \^eel bgmh jnZkmbe^l [r ma^ o^gmkZe Zg] ]hklZe g^ko^ \hk] Zl p^ee Zl ma^ eZm^kZe \hk]l #eZm^kZe ebg^l$) >$ >Zkmhhg h_ Z lhfZmb\ fnl\e^ \^ee lahpbg` ma^ libg]e^ #\hgmkZ\mbe^ iZkm$' pab\a \hgmZbgl ma^ mabg Zg] mab\d _beZf^gml k^lihglb[e^ _hk \hgmkZ\mbhg' Zg] ma^ [Z` #ghg(\hgmkZ\mbe^ ihkmbhg$' pab\a \hgmZbgl ma^ \^ee gn\e^nl) Dg Z]]bmbhg' Zg Zkf #ikhc^\mbhg mh ma^ g^ko^$ bl beenlmkZm^]' iZllbg` _khf ma^ [Zl^ h_ ma^ ghg(\hgmkZ\mbe^ ihkmbhg mh ma^ g^ko^ \hk])

-0 1NGVZKX &

NhfZmb\ fnl\e^ \^eel Zk^ ]bob]^] bgmh ]hklZe hk o^gmkZe eh\Zebl^] \^eel' lahpbg` k^\bikh\Ze [^aZobhnk bg m^kfl h_ \hgmkZ\mbhg Zg] k^eZqZmbhg) Oabl k^lneml bg ma^ mrib\Ze ]hklho^gmkZe lbgnlhb]Ze eh\hfhmbhg h_ g^fZmh]^l) Dg \hgmkZlm mh hma^k ZgbfZel' lhfZmb\ fnl\e^ \^eel h_ g^fZmh]^l l^g] ikhc^\mbhgl mh ma^ g^ko^l Zg] ghm ob\^ o^klZ) Jg Zo^kZ`^ ^Z\a lhfZmb\ fnl\e^ \^ee aZl -)2 h_ lh(\Zee^] Zkfl iZllbg` _khf ma^ [Zl^ h_ ma^ ghg(\hgmkZ\mbe^ ihkmbhg mh ma^ g^ko^ \hk]) @Z\a Zkf [kZg\a^l bgmh l^o^kZe _bg`^kl' pab\a _hkf cng\mbhgl pbma _bg`^kl h_ Z]cZ\^gm Zkfl' [nbe]bg` Z lh(\Zee^] lrg\rmbnf V-+W) Oa^ _hkf^] g^mphkd Z\\hngml _hk ma^ lb`gZe mkZglfbllbhg [^mp^^g bg]bob]nZe lhfZmb\ fnl\e^ \^eel) I^nkhfnl\neZk cng\mbhgl Zk^ _hkf^] [^mp^^g ma^ lrg\rmbnf Zg] ^qm^glbhgl h_ ma^ ehg`bmn]bgZe Zqhgl h_ ma^ fhmhg^nkhgl) Nbg\^' ]hklZe fnl\e^ \^eel Zk^ \hgg^\m^] hger mh ma^ ]hklZe g^ko^ \hk]' pa^k^Zl o^gmkZe fnl\e^ \^eel Zk^ \hgg^\m^] mh ma^ o^gmkZe g^ko^ \hk]' g^nkhfnl\neZk lb`gZeebg` hg ^Z\a lb]^ bl ahfh`^ghnl) Nb`gZeebg` bg ]hklZe Zg] o^gmkZe lb]^ bl k^\bikh\Ze' k^lnembg` bg eh\hfhmbhg Zehg` ma^ ]hklh(o^gmkZe ieZg^' hger) @e^\mkhiarlbheh`b\Ze lmn]b^l hg lhfZmb\ fnl\e^l \^eel h_ /# Y[[S lahp^]' maZm ma^ f^f[kZg^ ihm^gmbZe bl ZiikhqbfZm^er (.+ fQ Zg] eZk`^er ]^i^g]l hg \aehkb]^' _heehp^] [r lh]bnf Zg] ihmZllbnf #25/5,$) < eZk`^ gnf[^k h_ ^e^\mkhiarlbheh`b\Ze ^qi^kbf^gml pbma dghpg g^nkhmkZglfbmm^kl #lnffZkbl^] bg V-+W$' k^lnem^] bg \hgmkZ\mbhg h_ ma^ fnl\e^ hk bg ]^( hk ari^kiheZkblZmbhg h_ \^eel ]^fhglmkZmbg` maZm lb`gZeebg` Z\khll ma^ g^nkhgZe Zg] ma^ g^nkhfnl\neZk g^mphkd bl ^glnk^] [r g^nkhmkZglfbmm^kl' fZgr h_ pab\a Zk^ Zelh \hgl^ko^] bg o^km^[kZm^ g^kohnl lrlm^fl) Dg g^fZmh]^l' ma^ fZchk ^q\bmZmhkr mkZglfbmm^k bg ma^ g^nkhfnl\neZk cng\mbhg bl Z\^mre\ahebg^' pa^k^Zl ma^ fZbg bgab[bmhkr g^nkhmkZglfbmm^k bl '( Zfbgh[nmrkb\ Z\b] #B<=<$) Dg g^fZmh]^l' gb\hmbgb\ Z\^mre\ahebg^ k^\^imhkl #g<>aMl$ #l^glbmbo^ mh gb\hmbg^ Zg] Z\^mre\ahebg^$ p^k^ _hng] mh [^ ^qik^ll^] bg g^nkhgl Zg] fnl\e^ \^eel Zg] ma^bk Z\mboZmbhg k^lneml bg bgmkZ\^eeneZk \Ze\bnf bg\k^Zl^ Zg] _bgZeer bg ]^iheZkblZmbhg h_ ma^ \^ee) Dg Z]]bmbhg' B<=< < k^\^imhkl Zk^ Zelh ^qik^ll^] bg g^nkhgl Zg] lhfZmb\ fnl\e^ \^eel) Chp^o^k' hi^gbg` h_ ma^ \aZgg^e k^lneml bg ari^kiheZkblZmbhg' ]n^ mh Zg bg\k^Zl^ h_ bgmkZ\^eeneZk \aehkb]^) Dgm^k^lmbg`er' [^lb]^l bml _ng\mbhg Zl fZbg bgab[bmhkr g^nkhmkZglfbmm^k' B<=< bl Zelh Zg ^q\bmZmhkr g^nkhmkZglfbmm^k bg g^fZmh]^l Zm lhf^ bgm^kg^nkhg lrgZil^l) Oa^ g^nkhmkZglfbmm^k `enmZfZm^ Z\ml hg `enmZfZm^(`Zm^] \aehkb]^ \aZgg^el #Ben>el$) Oa^bk Z\mboZmbhg Zelh k^lneml bg ari^kiheZkblZmbhg ]n^ mh bgmkZ\^eeneZk bg\k^Zl^ h_ \aehkb]^) Ankma^kfhk^' l^khmhgbg #0(CO$' Z eZk`^ gnf[^k h_ ]b__^k^gm AHMAZfb]^(ebd^ i^imb]^l Zg] gbmkb\ hqb]^ #IJ$ p^k^ lahpg mh [^ bgoheo^] bg g^nkhfnl\neZk \hgmkhe bg g^fZmh]^l)

-1 5KTKXGR 7TZXUJ[IZOUT

,)-)/ M^e^oZg\^ h_ g^fZmh]^l

kZb` >) H^eeh "_hk ma^bk ]bl\ho^kr h_ MI< bgm^k_^k^g\^ ( `^g^ lbe^g\bg` [r ]hn[e^(lmkZg]^] MI<" V-3W Zg] bg -++3' ma^ Ih[^e Kkbs^ bg \a^fblmkr pZl ZpZk]^] chbgmer mh JlZfn NabfhfnkZ' HZkmbg >aZe_b^ Zg] Mh`^k T) Olb^g "_hk ma^ ]bl\ho^kr Zg] ]^o^ehif^gm h_ ma^ `k^^g _enhk^l\^gm ikhm^bg' BAK" V-4W) Chp^o^k' g^qm mh _k^^(ebobg` li^\b^l' iZkZlbmblf bl Z \hffhg eb_^ _hkf _hk Z eZk`^ gnf[^k h_ g^fZmh]^l' bg\en]bg` ieZgm Zg] ZgbfZe iZkZlbmb\ li^\b^l' aZobg` Z lmkhg` bfiZ\m hg anfZg Zg] ZgbfZe a^Zema Zg] \Znl^ mk^f^g]hnl _bgZg\bZe ehll^l bg Z`kb\nemnk^ Zg] ebo^lmh\d k^Zkbg` V.+W) Dg ma^ _heehpbg` mph l^\mbhgl ma^ bfiZ\m h_ g^fZmh]^l hg ZgbfZe Zg] anfZg a^Zema Zk^ ]^l\kb[^])

-2 1NGVZKX &

,)-)/), DfiZ\m hg ZgbfZe a^Zema

< mk^f^g]hnl oZkb^mr h_ g^fZmh]^l bg_^\m \hfiZgbhg ZgbfZel' bg\en]bg` \Zml Zg] ]h`l' Zl p^ee Zl `kZsbg` ZgbfZel Zl \Zmme^' la^^i' `hZml Zg] ahkl^l) Dg ebo^lmh\d bg]nlmkr' bg_^\mbhgl pbma iZkZlbmb\ g^fZmh]^l k^lnem bg ^ghkfhnl ^\hghfb\ ehll^l ]n^ mh k^]n\mbhgl bg `khpma kZm^l Zg] _bmg^ll Zg] manl k^]n\^] fbed' f^Zm Zg] phhe ikh]n\mbhg V.,W) MnfbgZgml Zk^ ik^]hfbgZgmer bg_^\m^] pbma `Zlmkhbgm^lmbgZe g^fZmh]^l [^ehg`bg` mh ma^ mkb\ahlmkhg`reb]l) 6GKSUTIN[Y IUTZUXZ[Y ' ?KRGJUXYGMOG IOXI[SIOTIZG ' ;YZKXZGMOG lii) Zg] ?XOINUYZXUTM_R[Y G^KO bgaZ[bm ma^ Z[hfZlnf' pa^k^Zl 1UUVKXOG UTIUVNUXG ' 1UUVKXOG VKIZOTGZG ' :KSGZUJOX[Y lii)' ?XOINUYZXUTM_R[Y IUR[HXOLUXSOY! ?XOINUYZXUTM_R[Y \OZXOT[Y Zk^ _hng] bg ma^ lfZee bgm^lmbg^) Dg fhlm \Zl^l fhk^ maZg hg^ li^\b^l Zk^ ik^l^gm bg ma^ bg]bob]nZe ahlm) Oa^l^ fnembie^ bg_^\mbhgl \Zg k^lnem bg o^kr a^m^kh`^g^hnl ]bl^Zl^ iZmm^kg' ]^i^g]bg` hg ma^ ik^]hfbgZgm li^\b^l Zg] ma^ bgm^glbmr h_ ma^ bg_^\mbhg) Dg_^\mbhgl pbma 1UUVKXOG lii # Zk^ h_ fbghk iZmaheh`b\Ze lb`gb_b\Zg\^' pa^k^Zl bg_^\mbhgl pbma ;YZKXZGMOG lii) Zk^ \hglb]^k^] mh [^ ma^ fhlm bfihkmZgm iZkZlbm^ bg `kZsbg` la^^i Zg] \Zmme^ bg m^fi^kZm^ \ebfZmb\ shg^l makhn`ahnm ma^ phke] V,3W) >ebgb\Ze ]bl^Zl^ bl \aZkZ\m^kbl^] [r lrfimhfl bg\en]bg` iZkmbZe Zghk^qbZ' fbe] ZgZ^fbZ' ariZe[nfbgZ^fbZ Zg] ]bZkkah^Z k^lnembg` bg lb`gb_b\Zgm p^b`am ehll Zg] ]^ar]kZmbhg Zg] bg lhf^ \Zl^l bg ]^Zma V,3W) ?n^ mh lnlmZbgZ[e^ iZlmnk^ fZgZ`^f^gm lrfimhfl h_ ;YZKXZGMOG lii) bg_^\mbhgl Zk^ fhlmer ln[\ebgb\Ze hk ebfbm^] mh k^]n\^] _bmg^ll) Dg \hgmkZlm' bg_^\mbhgl pbma [ehh](ln\dbg` 6# IUTZUXZ[Y _k^jn^gmer k^lnem bg l^o^k^ lrfimhfl bg\en]bg` \akhgb\ ZgZ^fbZ bg lfZee knfbgZgml) @li^\bZeer bg rhng` ZgbfZel i^klblmbg` bg_^\mbhgl Z__^\m ma^ k^libkZmbhg Zg] bg \hf[bgZmbhg pbma ma^ lb`gb_b\Zgm [ehh] ehll' aZ^fhg\ahlbl \Zg [^ e^maZe) I^qm mh mkb\ahlmkhg`reb]l' >ZXUTM_RUOJKY VGVORRUY[Y! 1GVORRGXOG lii) Zg] ;KYUVNGMUYZUS[S lii) Zk^ h_ bfihkmZg\^ bg knfbgZgml V,3W) >hfiZgbhg ZgbfZel Zk^ \hffhger bg_^\m^] pbma Z oZkb^mr h_ `Zlmkhbgm^lmbgZe g^fZmh]^l bg\en]bg` ma^ \eZ]^ DDD g^fZmh]^l ?U^UIGXG IGTOY #]h`l$' ?U^UIGXG IGZO #\Zml$ Zg] ?U^GYIGXOY RKUTOTG #\Zkgbohk^l$' ma^ \eZ]^ Q li^\b^l /TI_RUYZUSG Z[HGKLUXSGK #\Zml$' /TI_RUYZUSG IGTOT[S #]h`l$ Zg] @TIOTGXOG YZKTUIKVNGRG #\Zkgbohk^l$ Zl p^ee Zl ma^ \eZ]^ D pabiphkf ?XOIN[XOY \[RVOY #]h`l$) Oa^l^ bg_^\mbhgl \Zg k^lnem bg fn\nl Zg]*hk [ehh] bg _Z^\^l' Zghk^qbZ' ZgZ^fbZ' ]^ar]kZmbhg' ]bZkka^Z Zg] \Z\a^qbZ V.-W) ?n^ mh `eh[Ze pZkfbg` Zg] bg\k^Zl^] mkZo^e Z\mbobmr bg_^\mbhgl pbma iZkZlbm^l ik^obhnler k^lmkb\m^] mh H^]bm^kkZg^Zg Zk^Zl bg @nkhi^ ln\a Zl ma^ _beZkbZ^ 2OXULORGXOG XKVKTY Zg] 2OXULORGXOG OSSOZOY Zk^ h_ bg\k^Zlbg` bfihkmZg\^ bg B^kfZgr V..(.0W)

-3 5KTKXGR 7TZXUJ[IZOUT

,)-)/)- DfiZ\m hg anfZg a^Zema

C^efbgma bg_^\mbhgl Zk^ Zfhg` ma^ fhlm ik^oZe^gm Zg] i^klblm^gm bg_^\mbhgl bg iho^kmr( lmkb\d^g Zg] k^lhnk\^(\hglmkZbg^] k^`bhgl' mrib\Zeer Zllh\bZm^] pbma ln[himbfZe ar`b^gb\ \hg]bmbhgl bg ln[(NZaZkZg <_kb\Z' ma^ ZXUTM_RUOJKY YZKXIUXGROY Zg] ma^ ibgphkf 3# \KXSOI[RGXOY Zk^ Zelh ab`aer ik^oZe^gm `Zlmkhbgm^lmbgZe a^efbgma bg_^\mbhg pbma ZiikhqbfZm^er .+(,++ fbeebhg Zg] 0++ fbeebhg bg_^\mbhgl' k^li^\mbo^er V.4'/+W) Rhke]pb]^' ZggnZeer ZiikhqbfZm^er ,.0'+++ ]^Zmal Zk^ ^lmbfZm^] mh [^ Z ]bk^\m k^lnem h_ lhbe(mkZglfbmm^] a^efbgmahl^l V/,W) Cb`a ik^oZe^g\^ h_m^g \hf^l Zehg` pbma ab`a Z[ng]Zg\^ h_ ikhm^bg ^g^k`r fZegnmkbmbhg Zg] ZgZ^fbZ Zl p^ee Zl ebfbm^] Z\\^ll mh f^]b\Ze \Zk^ Zg] ^]n\ZmbhgZe hiihkmngbmb^l V/-W) Hbe] bg_^\mbhgl Zk^ h_m^g ZlrfimhfZmb\ [nm l^o^k^ Zg] \akhgb\ bg_^\mbhgl \Zg k^lnem bg bkhg( ]^_b\b^g\r ZgZ^fbZ' \akhgb\ bg_eZffZmbhg h_ ma^ bgm^lmbg^' k^\mZe ikheZil^' ihhk `khpma' \en[[bg` h_ ma^ _bg`^kl Zl p^ee Zl bgm^ee^\mnZe k^mZk]Zmbhg V/-(/0W) Oa^ bfiZ\m h_ a^efbgma bg_^\mbhgl hg anfZg a^Zema bl _k^jn^gmer ^qik^ll^] [r k^_^kkbg` mh ]blZ[bebmr(Z]cnlm^] eb_^ r^Zkl #?

-4 1NGVZKX & maZg ,)/ [beebhg i^hie^ Zk^ Zm kbld h_ bg_^\mbhg V/3W) Oh`^ma^k' GA Zg] hg\ah\^k\bZlbl Zk^ k^lihglb[e^ _hk 1). fbeebhg ?

)&+ ;SZ[W\bV Q]\b`]Z

,).), >hgmkhe h_ ieZmra^efbgmal

Nbg\^ ieZmra^efbgmal aZo^ ghm [^^g bgmkh]n\^] bg ]^mZbe bg l^\mbhg ,)-' lhf^ bfihkmZgm iZkZlbm^l h_ anfZgl Zg] ZgbfZel Zk^ bgmkh]n\^] a^k^ [^_hk^ lnffZkblbg` ma^ k^li^\mbo^ \a^fhma^kZi^nmb\l) Dg anfZgl' _hh]([hkg^ mk^fZmh]^l Zg] \^lmh]^l Zk^ h_m^g \hglb]^k^] mh [^ ikh[e^fl h_ hger k^`bhgZe bgm^k^lm) Chp^o^k' _end^l Zg] mZi^phkfl h\\nk Zee ho^k ma^ phke]'

.+ 5KTKXGR 7TZXUJ[IZOUT pbma ma^ ab`a^lm ik^oZe^g\^ bg ]^o^ehibg` \hngmkb^l V00W) Dg anfZgl ma^ fhlm ik^oZe^gm mk^fZmh]^l Zk^ 1RUTUXINOY YOTKTYOY pbma .0 fbeebhg' INOYZUYUSG lii) Zg] \^lmh]^l' ma^ g^qm l^\mbhg bgmkh]n\^l ikZsbjnZgm^e bg fhk^ ]^mZbe)

,).),), KkZsbjnZgm^e

KkZsbjnZgm^e' lrgma^lbl^] bg ma^ fb] ,42+l pbma ma^ bgm^gmbhg mh ]^o^ehi Z anfZg mkZgjnbebs^k V.4W' k^fZbgl ma^ `he] lmZg]Zk] ]kn` _hk ma^ mk^Zmf^gm h_ Zee anfZg bg_^\mbhgl pbma [ehh] _end^l V1,W' _hh]([hkg^ _end^l' ^q\^im _hk 4GYIOURG lii) V.4W Zg] \^lmh]^l V00W) Dg ,424 ma^ lZ_^mr Zg] [khZ](li^\mknf ^__b\Z\r h_ ikZsbjnZgm^e Z`Zbglm >INOYZUYUSG lii) p^k^ lahpg bg \ebgb\Ze anfZg mkbZel V1,W) Dm bl lmbee _k^jn^gmer nl^] Z`Zbglm bg_^\mbhgl pbma bffZmnk^ Zg] fZmnk^ lmZ`^l h_ >INOYZUYUSG SGTYUTO Zg] >INOYZUYUSG PGVUTOI[S #eh\Zeer >INOYZUYUSG OTZKXIGRGZ[S Zg] >INOYZUYUSG SKQUTMO $ Zl p^ee Zl >INOYZUYUSG NGKSGZUHO[S Zg] ., 1NGVZKX &

>INOYZUYUSG SGZNKOO V0/W Zl p^ee Zl Z`Zbglm anfZg Zg] ZgbfZe \^lmh]^ bg_^\mbhgl) Chp^o^k' ma^ fh]^ h_ Z\mbhg h_ ikZsbjnZgm^e bl ghm \hfie^m^er ng]^klmhh]) Dm bl dghpg maZm mk^Zmf^gml pbma ikZsbjnZgm^e k^lnem bg ]blbgm^`kZmbhg h_ ma^ iZkZlbm^Ål f^f[kZg^' Z__^\mbg` l^o^kZe f^f[kZg^ _ng\mbhgl V00W) Ankma^kfhk^' bm aZl [^^g lahpg' maZm ikZsbjnZgm^e ]blkniml ma^ \Ze\bnf ahf^hlmZlbl bg Z]nem l\ablmhlhf^l [r bgm^kZ\mbhg pbma Z &(ln[ngbm h_ Z ohemZ`^(`Zm^] \Ze\bnf \aZgg^e V1-W) Nbg\^ ikZsbjnZgm^e bl ma^ `he] lmZg]Zk] ]kn` Z`Zbglm ieZmra^efbgma bg_^\mbhgl bm bl ZeZkfbg` maZm k^lblmZg\^ mh ikZsbjnZgm^e aZl Zek^Z]r [^^g h[l^ko^] bg l\ablmhlhf^l V1.W Zg] bg ?# YGMOTGZG V1/W)

,).)- >hgmkhe h_ g^fZmh]^l

Kkhfblbg` k^lneml bg oZ\\bgZmbhg mkbZel Z`Zbglm 6# IUTZUXZ[Y bg la^^i V10W Zg] Z`Zbglm :# GSKXOIGT[Y bg anfZgl V11'12W ln``^lm maZm e^ll(\a^fhma^kZir ]^i^g]^gm \hgmkhe lmkZm^`b^l fb`am [^ _^Zlb[e^ bg _nmnk^) =nm lbg\^ gh oZ\\bg^ aZl ln\\^ll_neer iZll^] \ebgb\Ze mkbZel r^m' nl^ h_ Zgma^efbgmb\l pbee k^fZbg ma^ `he] lmZg]Zk] mh \hgmkhe ZgbfZe Zg] anfZg a^efbgma bg_^\mbhg bg ma^ _hk^l^^Z[e^ _nmnk^) Oa^ Rhke] C^Zema Jk`ZgbsZmbhg #RCJ$ eblm _hk ^ll^gmbZe f^]b\bg^l _hk Z]neml Zg] \abe]k^g \hgmZbgl hger _hnk ]kn`l #ma^ [^gsbfb]Zshe^l Ze[^g]Zshe^' f^[^g]Zshe^ Zg] ma^ \ahebg^k`b\ ]kn`l e^oZfblhe^ Zg] irkZgm^e$ _hk ma^ mk^Zmf^gm Z`Zbglm bg_^\mbhgl pbma `Zlmkhbgm^lmbgZe g^fZmh]^l Zg] hger mak^^ ]kn`l #Ze[^g]Zshe^' ]b^mare\Zk[ZfZsbg^ Zg] bo^kf^\mbg$ _hk ma^ mk^Zmf^gm h_ _beZkbZlbl V13'14W) NbfbeZk mh Zefhlm Zee Zgma^efbgmb\l nl^] bg anfZgl' ma^l^ ]kn`l p^k^ bgbmbZeer ]^o^ehi^] _hk o^m^kbgZkr nl^ lbg\^ ma^k^ bl Z lb`gb_b\Zgm \hff^k\bZe o^m^kbgZkr fZkd^m _hk Zgma^efbgmb\l V2+W) Nbg\^ Z\\^ll mh a^Zema l^kob\^l Zg] ^]n\Zmbhg' ^ib]^fbheh`b\Ze fhgbmhkbg` Zg] ^__^\mbo^ lZgbmZmbhg Zk^ aZk]er ZoZbeZ[e^ bg fZgr h_ ma^ ^g]^fb\ Zk^Zl _hk anfZg a^efbgmahlbl' ma^ fZll ]kn` Z]fbgblmkZmbhg #H?<$ \ZfiZb`gl [^\Zf^ Z ln\\^ll_ne lmkZm^`r _hk ma^ mk^Zmf^gm Z`Zbglm lhbe(mkZglfbmm^] a^efbgmahlbl Zg] _beZkbZlbl V2+'2,W) Oa^ \a^fhma^kZi^nmb\ \hgmkhe h_ g^fZmh]^ bg_^\mbhgl h_ ZgbfZel Zg] anfZgl lmkhg`er k^eb^l hg mak^^ ]kn` \eZll^l5 Oa^ [^gsbfb]Zshe^l' ma^ \ahebg^k`b\ ]kn`l #\hglblmbg` h_ ma^ bfb]ZshmabZshe^l Zg] m^mkZar]khirkbfb]bg^l$ Zg] ma^ fZ\kh\r\eb\ eZ\mhg^l) Chp^o^k' [^_hk^ ma^ bgmkh]n\mbhg h_ ma^ _bklm fh]^kg [khZ](li^\mknf Zgma^efbgmb\l pbma k^ZlhgZ[e^ lZ_^mr ikh_be^l bg ma^ ,41+l' Z oZkb^mr h_ gZkkhp(li^\mknf ]kn`l pbma l^o^k^ mhqb\heh`r ikh_be^l p^k^ pb]^er nl^]) ?n^ mh ma^ ^qm^glbo^ nl^ h_ ibi^kZsbg^ bg ma^ iZlm Zg] ma^ hg`hbg` bfihkmZg\^ h_ ]b^mare\Zk[ZfZsbg^ Zl _beZkb\b]Ze ]kn`' ma^r pbee [^ bgmkh]n\^] bg Z]]bmbhg mh ma^ mak^^ fZchk \eZll^l)

.- 5KTKXGR 7TZXUJ[IZOUT

,).)-), ?b^mare\Zk[ZfZsbg^

Dg ,4/3' ]b^mare\Zk[ZfZsbg^ pZl bgmkh]n\^] _hk ma^ mk^Zmf^gm h_ anfZg _beZkbZlbl V0.W) <_m^k fhk^ maZg _b_mr r^Zkl h_ nl^ bg _beZkbZe \hgmkhe' bm lmbee k^fZbgl Z \hffhg ]kn` Z`Zbglm bg_^\mbhgl pbma B# HGTIXULZO ' 0# SGRG_O! 0# ZOSUXO V2-W Zg] 8# RUG V2.W) Ok^Zmf^gm pbma ]b^mare\Zk[ZfZsbg^ Zelh Zii^Zkl mh ln[lmZgmbZeer ]^\k^Zl^ 9# VKXYZGTY fb\kh_beZkbZe ehZ]l bg anfZg [ehh] V2/W) <]]bmbhgZeer mh bml ma^kZi^nmb\Ze ^__^\ml Z`Zbglm Z\nm^ Zg] \akhgb\ \Zl^l h_ fb\kh_beZkZ^fbZ V2-W' bm Zelh aZl iZkmbZe fZ\kh_beZkbZe ^__b\Z\r Z`Zbglm ma^ Z[ho^ f^gmbhg^] li^\b^l bg ZggnZe mk^Zmf^gm k^`bf^gl V20W) ?n^ mh ma^ kZib] ]^Zma h_ fb\kh_beZkbZ^' lb`gb_b\Zgm bg_eZffZmbhg Zg] iZbg bg ma^ lnkkhng]bg` mblln^ Zk^ ma^ \hgl^jn^g\^ V20W) Oa^k^_hk^' ]b^mare\Zk[ZfZsbg^ bl ghm nl^] bg Zk^Zl pa^k^ hg\ah\^k\bZlbl bl \h(^g]^fb\' [^\Znl^ bm bg]n\^l lmkhg` eh\Ze bg_eZffZmbhg bg iZmb^gml pbma h\neZk fb\kh_beZkbZ^ V2-W) Oa^ fh]^ h_ Z\mbhg h_ ]b^mare\Zk[ZfZsbg^ bl ghm \hfie^m^er ng]^klmhh]) Ahk fb\kh_beZkbZ^' Zg bgm^kZ\mbhg h_ ]b^mare\Zk[ZfZsbg^ pbma ma^ ^g]hma^ebZe \^eel h_ ma^ ahlm Zg] ma^ ^b\hlZghb] ikh]n\mbhg h_ ma^ phkfl p^k^ ln``^lm^]' fZdbg` ma^ fb\kh_beZkbZ^ lnl\^imb[e^ mh Zg bffngheh`b\Ze ZmmZ\d [r ma^ bffng^ lrlm^f h_ ma^ ahlm V21W) Dg Z]]bmbhg mh bml nl^ bg anfZg f^]b\bg^' ]b^mare\Zk[ZfZsbg^ pZl eZk`^er nl^] bg ma^ ik^o^gmbhg h_ \Zgbg^ a^Zkmphkf ]bl^Zl^l) ?n^ mh ma^ fZ\kh\r\eb\ eZ\mhg^l ma^ Ziieb\Zmbhg h_ ]b^mare\Zk[ZfZsbg^ Z`Zbglm 2# OSSOZOY bl lb`gb_b\Zgmer k^]n\^] ghpZ]Zrl V22W)

,).)-)- Kbi^kZsbg^

Kbi^kZsbg^ pZl eZng\a^] bg ma^ fb] ,40+l Zl Z ]kn` mh mk^Zm anfZg /# R[SHXOIUOJKY Zg] 3# \KXSOI[RGXOY bg_^\mbhgl V0-'21W) Dm pZl lrgma^mb\Zeer ]^lb`g^] Zl Z k^lnem h_ ma^ Zgmb_beZkbZe ihm^g\r h_ ]b^mare\Zk[ZfZsbg^ V0.W) Chp^o^k' ma^ fh]^ h_ Z\mbhg pZl _hng] mh [^ ]b__^k^gm)

Kbi^kZsbg^ Z\ml Zl Z p^Zd B<=<(fbf^mb\ Zg] ]bk^\mer Z\mboZm^l B<=< < \aZgg^el #K#M ) ahfhf^kb\ Zg] a^m^khf^kb\ PI>(/4 \aZgg^el h_ 6# IUTZUXZ[Y $ V23W) Oa^ Z\mboZmbhg h_ ma^ \aZgg^el \Znl^l ari^kiheZkblZmbhg h_ ma^ [h]r pZee fnl\e^ Zg] _bgZeer k^lneml bg _eZ\\b] iZkZerl^l h_ ma^ phkf V21W) Nbg\^ ibi^kZsbg^ [bg]l hger k^o^klb[e^ mh B<=< < \aZgg^el' lahpg bg lbg`e^ \aZgg^e k^\hk]bg`l h_ /# Y[[S [h]r fnl\e^l V24W' ^qi^ee^] phkfl Zk^ lmbee Zebo^ Z_m^k mk^Zmf^gm V0.W) ?n^ mh ma^ ebfbm^] li^\mknf' ma^ nl^ h_ ibi^kZsbg^ aZl ]^\ebg^] lbg\^ ma^ bgmkh]n\mbhg h_ ma^ g^p^k [khZ](li^\mknf Zgma^efbgmb\l V21W)

.. 1NGVZKX &

,).)-). =^gsbfb]Zshe^l

OabZ[^g]Zshe^' pab\a pZl bgmkh]n\^] bgmh ma^ fZkd^] bg ,41,' k^ik^l^gml ma^ _bklm fh]^kg [khZ](li^\mknf Zgma^efbgmb\ V3+W) ?n^ mh ma^ ^q\^imbhgZe ikh_be^ h_ mabZ[^g]Zshe^' l^o^kZe mahnlZg] [^gsbfb]Zshe^l p^k^ lrgma^lbl^] _hk ^oZenZmbhg h_ Zgma^efbgmb\ ^__b\Z\r) Chp^o^k' hger e^ll maZg mp^gmr aZo^ k^Z\a^] \hff^k\bZe nl^ V3,W) Plbg` _Zbker ehp ]hlZ`^l #,(0 ]hlZ`^l h_ 0(,+ f`*d`$ h_ ^bma^k [^gsbfb]Zshe^l' [^gsbfb]Zshe^ \Zk[ZfZm^l hk ikh( [^gsbfb]Zshe^l' lZ_^ \hgmkhe h_ `Zlmkhbgm^lmbgZe g^fZmh]^ bg_^\mbhgl bg\en]bg` bffZmnk^ lmZ`^l bg Z oZkb^mr h_ ahlml pZl ^glnk^] V21'3-W) Ankma^kfhk^' ma^ [^gsbfb]Zshe^l Zelh aZo^ ihm^gm hob\b]Ze ^__^\ml V3.W) I^qm mh ma^bk bfihkmZg\^ bg ZgbfZe a^Zema' ma^ [^gsbfb]Zshe^l mabZ[^g]Zshe^' Ze[^g]Zshe^ Zg] f^[^g]Zshe^ p^k^ Zg] lmbee Zk^ ^ll^gmbZe _hk ma^ Zgma^efbgmb\ \a^fhma^kZir bg anfZg f^]b\bg^ V3-W)

,).)-)/ >ahebg^k`b\ ]kn`l

=Zl^] hg ma^bk fh]^ h_ Z\mbhg #Z`hgblml h_ Z\^mre\ahebg^ k^\^imhkl' <>aMl$' bfb]ZshmabZshe^l #e^oZfblhe^ Zg] m^mkZfblhe^$ V32W Zg] m^mkZar]khirkbfb]bg^l #irkZgm^e' fhkZgm^e Zg] hqZgm^e$ V33W Zk^ \Zm^`hkbl^] Zl Z \hee^\mbo^ \eZll h_ [khZ](li^\mknf Zgma^efbgmb\l) Ankma^kfhk^' ma^ ./ 5KTKXGR 7TZXUJ[IZOUT g^p^k ]kn` \eZll^l' Zfbghia^greZfb]bg^l #l^\mbhg ,)0),$' libkhbg]he^l #l^\mbhg ,)0).$ Zg] Zfbgh(Z\^mhgbmkbe^ ]^kboZmbo^l #l^\mbhg ,)0)/$ p^k^ _hng] mh Z\m hg <>aMl) Chp^o^k' ]^mZbel hg ma^ g^p^k ]kn` \eZll^l Zk^ `bo^g bg ma^ k^li^\mbo^ l^\mbhgl) aM Zk^ ik^l^gm bg g^fZmh]^l Zg] maZm [hma' e^oZfblhe^ Zg] irkZgm^e l^e^\mbo^er Z\mboZm^ Z k^lmkb\m^] ln[`khni h_ <>aMl) @Z\a <>aM bl \hfihl^] h_ _bo^ ln[ngbml bg\en]bg` #( Zg] ghg( #( hk &(ln[ngbml V4+W) Dg 1# KRKMGTY Zm e^Zlm -2 `^g^l ^g\h]^ _hk <>aM ln[ngbml) Oa^ \aZgg^el l^glbmbo^ mh e^oZfblhe^ Zg] irkZgm^e \hglblm h_ ma^ #(ln[ngbml PI>(1.' PI>(.3 Zg] G@Q(3 Zl p^ee Zl h_ ma^ &(ln[ngbml PI>(-4 Zg] G@Q(, V4,W) Dg Zee g^fZmh]^l' ahfheh`l _hk [TI"'.' [TI"(- Zg] [TI"+( aZo^ [^^g b]^gmb_b^]) Dgm^k^lmbg`er' bg 6# IUTZUXZ[Y Zg] ?# IOXI[SIOTIZG _hnk ]blmbg\m [TI"'. iZkZeh`l aZo^ [^^g _hng] V4-W) Chp^o^k' ahfheh`l mh RK\"& aZo^ hger [^^g b]^gmb_b^] bg \eZ]^ Q g^fZmh]^l [nm ghm bg \eZ]^ DDD Zg] \eZ]^ D) Ankma^kfhk^' mkb\ahlmkhg`reb] RK\"& eZ\dl Z lb`gZe i^imb]^' ln``^lmbg` maZm mabl ln[ngbm fb`am ghm [^ bgoheo^] bg <>aMl l^glbmbo^ mh e^oZfblhe^) AbgZeer' ma^k^ bl Zelh gh ^ob]^g\^ _hk ahfheh`l mh RK\"- bg mkb\ahlmkhg`reb]l) Chp^o^k' ahfheh`l h_ GIX"- ' pab\a Zk^ \ehl^er k^eZm^] mh RK\"- ' aZo^ [^^g ]^l\kb[^] _hk iZkZlbmb\ g^fZmh]^l V4+W) C^m^kheh`hnl ^qik^llbhg h_ ]b__^k^gm ln[l^ml h_ ma^ k^\^imhk ln[ngbml bg CKTUV[Y RGK\OY hh\rm^l `Zo^ _nkma^k bglb`am bgmh ma^ fh]^ h_ Z\mbhg h_ ma^ \ahebg^k`b\ ]kn`l) Hb\khbgc^\mbhg h_ 1# KRKMGTY ng\(.3' ng\(1.' e^o(3' ng\(-4 Zg] e^o(, \MIaMl p^k^ b]^gmb_b^] bg /# Y[[S ) ?^i^g]bg` hg ma^ lmhb\abhf^mkb\ \hf[bgZmbhg h_ PI>(-4 Zg] PI>(.3' \aZgg^el p^k^ ^bma^k fhk^ l^glbmbo^ mh e^oZfblhe^ Zg] irkZgm^e maZg mh gb\hmbg^ hk fhk^ l^glbmbo^ mh hqZgm^e Zg] gb\hmbg^ maZg mh e^oZfblhe^' k^li^\mbo^er V4.W) Hb\khbgc^\mbhg h_ 6# IUTZUXZ[Y ln[ngbml lahp^]' maZm _hnk ]blmbg\m ln[ngbml #PI>(1.' PI>(-4' PI>(.3 Zg] <>M(3 p^k^ k^jnbk^] mh _hkf Z \aZgg^e ab`aer l^glbmbo^ mh e^oZfblhe^ _heehp^] [r ma^ l^glbmbobmr mh Z\^mre\ahebg^ Zg] ihhker k^lihglbo^ mh irkZgm^e Zg] gb\hmbg^) Chp^o^k' bgc^\mbhg h_ hger ng\(1.' ng\(-4' ng\(.3 \MI

.0 1NGVZKX & bg]b\Zmbg` maZm <>M(3 ieZrl Z \kn\bZe khe^ bg e^oZfblhe^ [nm ihm^gmbZeer ghm bg irkZgm^e lnl\^imb[bebmr V4+W) NbfbeZk _bg]bg`l \hg\^kgbg` ma^ g^\^llbmr h_ <>M(3 _hk ^__^\ml h_ e^oZfblhe^ [nm ghm irkZgm^e aZo^ [^^g h[l^ko^] bg ;# JKTZGZ[S V4/W) Oa^l^ h[l^koZmbhgl \e^Zker lahp' maZm Zgma^efbgmb\ ^__^\ml h_ \ahebg^k`b\ <>aM Z`hgblml aZo^ mh [^ ZgZerl^] bg ^Z\a g^fZmh]^ li^\b^l h_ bgm^k^lm bg]bob]nZeer Zg] maZm 1# KRKMGTY fb`am ghm [^ Z lnbmZ[e^ fh]^e _hk l\k^^gbg` h_ g^p Zgma^efbgmb\l Z\mbg` hg <>aMl) Dm lahne] [^ f^gmbhg^] maZm e^oZfblhe^ Zg] irkZgm^e Zk^ ab`aer ^__^\mbo^ Z`Zbglm bg_^\mbhgl pbma /# R[SHXOIUOJKY ' [nm hger fh]^kZm^er ^__^\mbo^ Z`Zbglm ahhdphkf li^\b^l) @__b\Z\b^l Z`Zbglm ?# ZXOINO[XG p^k^ k^ihkm^] mh [^ hger ,+(., nlbg` ^bma^k ,+ f`*d` irkZgm^e hk -)0 f`*d` e^oZfblhe^ V.4W)

,).)-)0 HZ\kh\r\eb\ eZ\mhg^l

ZXKVZUS_IKY V40W) Dg ,42.' NZgdrh ]bl\ho^k^] fbe[^fr\bgl Zl Z\Zkb\b]Ze Zg] bgl^\mb\b]Ze \hfihng]l _hk \khi ikhm^\mbhg) Chp^o^k' ma^ _nee iZkZlbmb\b]Ze ikh_be^' bg\en]bg` Z\Zkb\b]Ze' bgl^\mb\b]Ze Zg] g^fZmh\b]Ze ^__b\Z\r' pZl hger k^\h`gbl^] pbma ma^ ]bl\ho^kr h_ Zo^kf^\mbgl [r H^k\d bg ,420) Oabl \hf[bgZmbhg h_ ^__b\Z\b^l hi^g^] Z g^p \aZim^k bg ma^ mk^Zmf^gm h_ ^g]hiZkZlbmhlbl Zg] ^\mhiZkZlbmhlbl bg anfZg Zg] ZgbfZe a^Zema) HZ\kh\r\eb\ eZ\mhg^l Zk^ ma^k^_hk^ h_m^g \Zee^] ^g]^\mh\b]^l V40W) < l^fblrgma^mb\ ]^kboZmbo^ h_ ma^ _^kf^gmZmbhg ikh]n\m Zo^kf^\mbg' gZf^] bo^kf^\mbg' lahp^] Zg ^q\^imbhgZe [khZ](li^\mknf Zg] ehg`(eZlmbg` ^__b\Z\r Z`Zbglm iZkZlbm^l nlbg` o^kr ehp ]hlZ`^l V41W) ?n^ mh ma^ ^q\^imbhgZe ln\\^ll h_ ma^ bgmkh]n\mbhg h_ bo^kf^\mbg bgmh ma^ fZkd^m bg ho^k 1+ \hngmkb^l bg ,43,' Z eZk`^ gnf[^k h_ Zo^kf^\mbg ]^kboZmbo^l #bg\en]bg` Z[Zf^\mbg' ]hkZf^\mbg' ^ikbghf^\mbg Zg] l^eZf^\mbg$ Zl p^ee Zl fbe[^fr\bgl #bg\en]bg` fbe[^fr\bg ?' fbe[^fr\bg hqbf^ Zg] fhqb]^\mbg$ aZo^ _heehp^]) HZ\kh\r\eb\ eZ\mhg^l [^\Zf^ ma^ `he] lmZg]Zk] [khZ](li^\mknf iZkZlbmb\b]^l bg lfZee Zg] eZk`^ knfbgZgml V40W Zg] ma^ _bklm ]kn` mh ik^o^gm a^Zkmphkf bg_^\mbhgl bg ]h`l #fZ\kh\r\eb\ eZ\mhg^l lmbee k^fZbg ma^ hger \eZll mh ]h lh$ V22W) ?n^ mh ma^ ]hgZmbhg [r H^k\d ! >h) bg ,432' bo^kf^\mbg bl Zelh nl^] mh mk^Zm anfZg hg\ah\^k\hlbl V42W pbmabg ma^ _kZf^phkd h_ mph fZchk ikhc^\ml5 Oa^ Jg\ah\^k\bZlbl @ebfbgZmbhg Kkh`kZf h_ ma^

`hZe mh ^ebfbgZm^ hg\ah\^k\hlbl _hkf ma^ \hgmbg^gm' Zg] ma^ <_kb\Zg Kkh`kZf _hk Jg\ah\^k\bZlbl >hgmkhe Zk^ fhobg` mhpZk]l ma^ ^ebfbgZmbhg h_ ma^ bg_^\mbhg V44W) Ankma^kfhk^' ma^ Beh[Ze Kkh`kZf mh @ebfbgZm^ GrfiaZmb\ AbeZkbZlbl mk^Zml i^hie^ bg k^`bhgl pa^k^ ;# \UR\[R[Y Zg] GA Zk^ \h(^g]^fb\ pbma Z \hf[bgZmbhg h_ ,0+ `*d` bo^kf^\mbg Zg] /++ f` Ze[^g]Zshe^ V,++W) Oa^ fh]^ h_ Z\mbhg h_ fZ\kh\r\eb\ eZ\mhg^l Z`Zbglm g^fZmh]^l bl p^ee bgo^lmb`Zm^]) Oa^r [bg] pbma Zg ^qmk^f^er ab`a Z__bgbmr mh g^fZmh]^ Ben>el V,+,W) Nbm^(]bk^\m^] fnmZ`^g^lbl lmn]b^l ln``^lmbg` ma^ [bg]bg` lbm^ h_ bo^kf^\mbg mh Ben>e V,+-',+.W aZo^ k^\^gmer [^^g \hg_bkf^] [r ma^ in[eb\Zmbhg h_ ma^ .? lmkn\mnk^ h_ bo^kf^\mbg [hng] mh ma^ 1# KRKMGTY Ben>e V,+/W) Oa^ Z\mboZmbhg h_ Ben>el bl o^kr lehp [nm ^ll^gmbZeer bkk^o^klb[e^) HZ\kh\r\eb\ eZ\mhg^l Zelh ihm^gmbZm^ ma^ Z\mboZmbhg h_ ma^ \aZgg^e [r `enmZfZm^' pab\a fb`am [^ h_ fZchk bfihkmZg\^ _hk OT \O\U ^__b\Z\r h_ fZ\kh\r\eb\ eZ\mhg^l) Dm bl ghm dghpg b_ fZ\kh\r\eb\ eZ\mhg^l Zk^ Z[e^ mh [bg] mh ma^ \ehl^] lmZm^ h_ \aZgg^e) Chp^o^k' hg\^ Ben>el Zk^ hi^g^] [r `enmZfZm^' [bg]bg` h_ fZ\kh\r\eb\ eZ\mhg^l ahe]l ma^ \aZgg^e bg Zg hi^g lmZm^ k^lnembg` bg Z eZlmbg` ari^kiheZkblZmbhg V,+0W)

)&, ESaWabO\QS

M^lblmZg\^ bl ma^ a^kbmZ[e^ Z[bebmr h_ Z iZkZlbm^ ihineZmbhg mh pbmalmZg] ma^ ^__^\ml h_ Z ]kn` Zm Z \hg\^gmkZmbhg' pab\a pZl ik^obhnler dghpg mh [^ ^__^\mbo^) Oabl Z[bebmr bl ^bma^k ]n^ mh ma^ ik^l^g\^ Zg] l^e^\mbhg h_ li^\b_b\ Zee^e^l bg ma^ hkb`bgZe' lnl\^imb[e^ ihineZmbhg' pab\a \Zg \hg_^k Zm e^Zlm iZkmbZe k^lblmZg\^ hk obZ fnmZmbhg hk k^\hf[bgZmbhg' ma^ ikh]n\mbhg h_ g^p Zee^e^l hk \hf[bgZmbhgl h_ Zee^e^l' pab\a Zk^ ma^g l^e^\m^] V,+1W) Oa^ ^qm^glbo^ nmbeblZmbhg h_ Zgma^efbgmb\l Zl fZchk f^Zgl h_ ma^ fZgZ`^] \hgmkhe h_ ^\hghfb\Zeer bfihkmZgm g^fZmh]^ li^\b^l' iZkmb\neZk bg ebo^lmh\d' k^lnem^] bg lmkhg` l^e^\mbhg h_ ab`aer k^lblmZgm g^fZmh]^ ihineZmbhgl V,+2',+3W) Oanl' ghpZ]Zrl ma^ lik^Z] h_ k^lblmZg\^ Z`Zbglm Zee ]kn` \eZll^l bg\en]bg` ma^ [^gsbfb]Zshe^l' \ahebg^k`b\ ]kn`l Zg] fZ\kh\r\eb\ eZ\mhg^l bl l^o^k^ ^ghn`a mh mak^Zm^g ^__^\mbo^ phkf \hgmkhe bg \Zmme^' `hZml' la^^i Zg] ahkl^l V,+1',+4(,,,W) Oph ^qZfie^l Zk^ `bo^g _hk ma^ kZib] hgl^m h_ Zgma^efbgmab\ k^lblmZg\^ bg ma^ o^m^kbgZkr _b^e]) OabZ[^g]Zshe^ pZl bgmkh]n\^] mh ma^ fZkd^m bg ,41, Zg] _bklm k^lblmZgm 6# IUTZUXZ[Y ihineZmbhgl bg la^^i pa^k^ b]^gmb_b^] hger mak^^ r^Zkl eZm^k V,,-W) NbfbeZk h[l^koZmbhgl aZo^ [^^g fZ]^ _hk fhg^iZgm^e) Jger _bo^ r^Zkl Z_m^k ma^ bgmkh]n\mbhg h_ fhg^iZgm^e #Uheobq Ä$ _bklm k^ihkml h_ k^lblmZgm blheZm^l h_ ?# IOXI[SIOTIZG Zg] ?# IUR[HXOLUXSOY bg `hZml aZo^ [^^g _hng] V,,.W) .2 1NGVZKX &

Oa^ ]^o^ehif^gm h_ k^lblmZg\^ bl [Zl^] hg Z aZg]_ne h_ \aZg`^l5 #b$ \aZg`^l bg ma^ fhe^\neZk mZk`^m h_ ma^ ]kn`' k^lnembg` bg Z ehll h_ ]kn` mZk`^m bgm^kZ\mbhg' #bb$ \aZg`^l bg f^mZ[heblf maZm Z$ bgZ\mboZm^ hk k^fho^ ma^ ]kn` hk [$ ik^o^gml bml Z\mboZmbhg' #bbb$ \aZg`^l bg ]blmkb[nmbhg h_ ma^ ]kn` ik^o^gmbg` ma^ ]kn` _khf k^Z\abg` bml mZk`^m hk bg\k^Zlbg` bml ^__enq #bo$ Zfieb_b\Zmbhg h_ mZk`^m `^g^l mh ho^k\hf^ ]kn` Z\mbhg V,,/W Zg] #o$ \hfi^glZmbhg h_ ma^ fhe^\neZk mZk`^m [r ^qik^llbhg h_ \ehl^er k^eZm^] ikhm^bgl ghm l^glbmbo^ mh ma^ ]kn` V4+'4/W) <\\hk]bg`er' f^\aZgblfl h_ k^lblmZg\^ Z`Zbglm [^gsbfb]Zshe^l' \ahebg^k`b\ ]kn`l Zg] fZ\kh\r\eb\ eZ\mhg^l Zk^ ]bo^kl^) M^lblmZg\^ Z`Zbglm [^gsbfb]Zshe^l pZl lahpg mh [^ Zllh\bZm^] pbma lbg`e^ gn\e^hmb]^ iherfhkiablfl #NIKl$ bg ma^ mZk`^m `^g^ HKT"& h_ 1# KRKMGTY ^g\h]bg` _hk &(mn[nebg) mh O<>$ h_ hkmaheh`l bg 1# KRKMGTY Zg] 6# IUTZUXZ[Y ' h_ \h]hg ,43 #B<< mh B><$ bg ma^ 6# IUTZUXZ[Y hkmaheh` Zl p^ee Zl h_ \h]hg ,12 #OO> mh O<>$ bg hkmaheh`l h_ l^o^kZe iZkZlbmb\ g^fZmh]^l k^lnem bg [^gsbfb]Zshe^ k^lblmZg\^ V,,0W) Oa^ \aZg`^l Zllh\bZm^] pbma \ahebg^k`b\ ]kn` k^lblmZg\^ p^k^ lahpg mh [^ li^\b^l Zg] ]kn` ]^i^g]^gm) Dg 1# KRKMGTY gnee fnmZmbhgl bg -, `^g^l' ^g\h]bg` _hk ikhm^bgl \Zm^`hkbl^] bg #b$ ln[ngbml h_ ma^ mZk`^m #<>aMl$' #bb$ ikhm^bgl k^lihglb[e^ _hk ]blmkb[nmbhg Zg] ikhi^k _ng\mbhg h_ <>aMl' #bbb$ ikhm^bgl Zllh\bZm^] pbma \Ze\bnf k^e^Zl^ Zg] \Ze\bnf l^glbmbo^ \hgmkZ\mbhg Zg] #bo$ Z\\^llhkr ikhm^bgl Zllh\bZm^] pbma ikh\^llbg`' Zll^f[er Zg] ]^ebo^kr h_ <>aM mh ma^ f^f[kZg^' k^lnem^] bg e^oZfblhe^ k^lblmZg\^) Dg ;# JKTZGZ[S Z k^]n\^] gnf[^k h_ k^\^imhkl bg ma^ fnl\e^ f^f[kZg^ Zg] Z ehll h_ Z li^\b_b\ <>aM ln[mri^ #B.0 iN' k^eZm^] mh ma^ lbg`e^(\aZgg^e \hg]n\mZg\^ $ p^k^ Zllh\bZm^] pbma e^oZfblhe^ k^lblmZg\^' pa^k^Zl irkZgm^e k^lblmZg\^ pZl Zllh\bZm^] pbma Z k^]n\^] gnf[^k h_ Zee \hg]n\mZg\^ ln[mri^l) Dg /# IGTOT[S irkZgm^e k^lblmZg\^ pZl Zllh\bZm^] pbma Z k^]n\^] ^qik^llbhg h_ ma^ <>aM ln[ngbml PI>(.3' PI>(1. Zg] PI>(-4 [nm ghm h_ <>M(3) Dg 6# IUTZUXZ[Y e^oZfblhe^ k^lblmZg\^ bl Zllh\bZm^] pbma Z mkng\Zm^] _hkf h_ PI>(1.) Okng\Zmbhg hk ehll h_ <>M(3 Zelh k^lneml bg e^oZfblhe^' [nm ghm irkZgm^e k^lblmZg\^) Oabl ln``^lml maZm ehll h_ <>M(3 k^lneml bg e^oZfblhe^ k^lblmZg\^ hger' pa^k^Zl ehll h_ PI>(1. e^Z]l mh k^lblmZg\^ Z`Zbglm [hma' e^oZfblhe^ Zg] irkZgm^e V4+W) M^lblmZg\^ Z`Zbglm fZ\kh\r\eb\ eZ\mhg^l bgoheo^l l^o^kZe h_ ma^ Z[ho^(f^gmbhg^] k^lblmZg\^ f^\aZgblfl bg\en]bg` \aZg`^l bg ma^ mZk`^m #6# IUTZUXZ[Y G\X"&)! MMX"(! MRI"* Zg] RMI"(, $' \aZg`^l bg ma^ fZ\kh\r\eb\ eZ\mhg^ f^mZ[heblf #fbq^](_ng\mbhg hqb]Zl^l' \Zk[hqre^lm^kZl^l Zg] `enmZmabhg^ N(mkZgl_^kZl^l$ Zg] \aZg`^l bg ma^ fZ\kh\r\eb\ eZ\mhg^ ]blmkb[nmbhg #ln[lmkZm^ h_ ma^ <=>(OkZglihkm^k ln[(_Zfber K(`er\hikhm^bgl$ V,+1W) @li^\bZeer' lbg\^ fZ\kh\r\eb\ eZ\mhg^l k^ik^l^gm ma^ hger \eZll h_ Zgma^efbgmb\l ln\\^ll_neer nl^] Zl ik^o^gmZmbo^ bg a^Zkmphkf ]bl^Zl^ bg ]h`l' ]^m^\m^] `^g^mb\ iherfhkiablfl bg &(mn[nebg' a^Zm lah\d ikhm^bg 1+' K(`er\hikhm^bgl Zg] ma^ lZk\h(

.3 5KTKXGR 7TZXUJ[IZOUT

^g]hieZlfb\ k^mb\nenf \Ze\bnf nkk^gmer' k^ihkml hg k^lblmZg\^ h_ anfZg a^efbgmal Z`Zbglm Zgma^efbgmb\l eblm^] hg ma^ ^ll^gmbZe eblm h_ f^]b\bg^l Zk^ kZk^) Chp^o^k' ma^ hgl^m Zg] kZib] lik^Z] h_ Zgma^efbgmb\ k^lblmZg\^ bg ma^ o^m^kbgZkr _b^e] V,+3W fnlm [^ \hglb]^k^] Zl Z k^Zeblmb\ l\^gZkbh _hk ma^ mk^Zmf^gm h_ anfZg a^efbgmahlbl Zl p^ee' ^o^g mahn`a bm fb`am ]^o^ehi lehp^k [^\Znl^ h_ e^ll _k^jn^gm mk^Zmf^gml) K^klblm^gm ng]^k]hlbg` h_ ahhdphkfl Zg] pabiphkfl pbmabg ma^ k^\^gmer bg\k^Zl^] H?< \ZfiZb`gl Z`Zbglm _beZkbhlbl fZr _Zohk l^e^\mbhg h_ ab`aer k^lblmZgm `^ghmri^l V2+W Zl Zek^Z]r ]^l\kb[^] _hk ?# ZXOINO[XG V,,2W) Ankma^kfhk^' h[l^koZmbhgl bg ;# \UR\[R[Y ihineZmbhgl lahp^] ln[(himbfZe k^lihgl^l Zg] `^g^mb\ \aZg`^l ng]^k ab`a bo^kf^\mbg ik^llnk^ V,,3W) Dg Z]]bmbhg' k^lblmZg\^ mh ikZsbjnZgm^e aZl [^^g h[l^ko^] bg l\ablmhlhf^l V1.W' [^gsbfb]Zshe^ k^lblmZg\^ aZl [^^g _k^jn^gmer k^ihkm^] bg ebo^k _end^l V,,4W Zg] [hma ikZsbjnZgm^e Zg] gb\ehlZfb]^ k^lblmZg\^ aZo^ [^^g _hng] bg ?# YGMOTGZG V1/',-+W' bg]b\Zmbg` maZm ehp^k mk^Zmf^gm _k^jn^g\b^l ]h ghm ik^o^gm ma^ hgl^m h_ k^lblmZg\^) Oanl' ^__b\b^gm Zg] lmkZm^`b\ fhgbmhkbg` _hk ^f^k`^g\^ h_ k^lblmZg\^ bl ^ll^gmbZe # K#M# [r ma^ nlZ`^ h_ `^g^mb\ fZkd^kl _hk b]^gmb_b\Zmbhg h_ lbg`e^ gn\e^hmb]^ iherfhkiablfl bg k^ihkm^k*mZk`^m `^g^l$ _hk Z lnlmZbgZ[e^ a^efbgma \hgmkhe bg anfZgl V2+W)

)&- 9cbc`S Q]\b`]Z ]T \S[Ob]RS W\TSQbW]\a l \Se R`cU QZOaaSa

Dm aZl [^^g ab`aeb`am^] maZm m a^ eZk`^lm iZkm h_ ma^ \hgmkhe h_ a^efbgma bg_^\mbhgl bg o^m^kbgZkr Zg] anfZg f^]b\bg^ k^eb^l hg \a^fhma^kZir nlbg` Zgma^efbgmb\l) @li^\bZeer pbma ma^ bgmkh]n\mbhg h_ ma^ fZ\kh\r\eb\ eZ\mhg^l bg ma^ ,43+l' [nm Zelh ]n^ mh ma^ [^gsbfb]Zshe^l Zg] \ahebg^k`b\ ]kn`l #bfb]ZshmabZshe^l Zg] m^mkZar]khirkbfb]bg^l$' ma^ \hgmkhe h_ g^fZmh]^ bg_^\mbhgl pZl lZ_^ Zg] ab`aer ^__^\mbo^ Zg] ma^k^_hk^' \ebgb\Ze Zg] ^\hghfb\ ikh[e^fl p^k^ \hglb]^k^] mh [^ lheo^]) >hgl^jn^gmer' k^l^Zk\a Zg] ]^o^ehif^gm h_ g^p ]kn` \eZll^l pZl eZk`^er ]bl\hgmbgn^] [r ma^ iaZkfZ\^nmb\Ze bg]nlmkr V,-,W) Chp^o^k' ]n^ mh ma^ bg\k^Zlbg` ik^oZe^g\^ h_ ab`aer k^lblmZgm phkf ihineZmbhgl' Zl ihbgm^] hnm [^_hk^' _nmnk^ \hgmkhe bl l^o^k^er mak^Zm^g^] V.4',-,W) Dg ma^ o^kr k^\^gm iZlm hger Z lbg`e^ g^p Zgma^efbgmb\ ]kn` \eZll' ma^ Zfbgh Z\^mhgbmkbe^ ]^kboZmbo^l #<

,)0),

Dg ma^ eZm^ ,42+l ma^ _bklm Zfbghia^greZfb]bg^' Zfb]Zgm^e' pZl Zmmkb[nm^] mh aZo^ Zgma^efbgmb\ ^__b\Z\r) Hnembie^ ]kn` Z]fbgblmkZmbhgl pbma k^eZmbo^er ab`a ]hlZ`^l #,++(0++ f`*d` [h]r p^b`am$ `bo^g mh kh]^gml k^lnem^] bg \hfie^m^ ^ebfbgZmbhg h_ Z pb]^ kZg`^ h_ iZkZlbmb\ g^fZmh]^l' K#M# h_ 2OVKZGRUTKSG ]OZKO ' 6KROMSUYUSUOJKY HGQKXO ' :OVVUYZXUTM_R[Y HXGYOROKTYOY Zg] >ZXUTM_RUOJKY XGZZO ' pa^k^Zl hger ehp ^__b\Z\r Z`Zbglm ?XOIN[XOY S[XOY pZl h[l^ko^] V,-.W) Dg Z]]bmbhg mh ma^ g^fZmb\b]Ze ^__^\ml' Zfb]Zgm^e pZl Zelh ]^l\kb[^] mh aZo^ [Zl^ebg^ ^__b\Z\r Z`Zbglm lhf^ ieZmra^efbgmal # K#M# fh]^kZm^ ^__b\Z\r Z`Zbglm 6_SKTURKVOY JOSOT[ZG [nm ghm Z`Zbglm 6_SKTURKVOY TGTG $ V,-.W) Oa^l^ k^lneml bg]b\Zm^] maZm Zfb]Zgm^e fb`am [^ Zg bgm^k^lmbg` e^Z] lmkn\mnk^ _hk ma^ ]^o^ehif^gm h_ Z g^p [khZ](li^\mknf Zgma^efbgmb\) Rabe^ lmn]rbg` Zfbghia^greZfb]bg^ lmkn\mnk^(Z\mbobmr k^eZmbhglabi' Z lrff^mkb\Ze ]bZfb]bg^ ]^kboZmbo^ h_ Zfb]Zgm^e' mkb[^g]bfb]bg^' pZl lrgma^lbl^] Zg] m^lm^] [r ma^ >abg^l^ IZmbhgZe Dglmbmnm^ h_ KZkZlbmb\ ?bl^Zl^l V,-2W) AZbker ehp ]hlZ`^l h_ mkb[^g]bfb]bg^ lahp^] ab`a ^__b\Z\r Z`Zbglm l^o^kZe iZkZlbmb\ g^fZmh]^l bg kh]^gml #0+(-++ f`*d` [h]r p^b`am$ Zg] ]h`l #1(-0 f`*d` [h]r p^b`am$ V,-2W) <`Zbg' bg Z]]bmbhg mh ma^ g^fZmb\b]Ze ^__^\ml' mkb[^g]bfb]bg^ pZl Zelh _hng] mh [^ ^__b\Z\bhnl Z`Zbglm l^o^kZe mk^fZmh]^l #b)^) 3INOTUYZUSG IGVXUTO ' 1# YOTKTYOY ' ;VOYZNUXINOY \O\KXXOTO $' pa^k^Zl gh ^__^\ml Z`Zbglm 4# NKVGZOIG Zg] ># SGTYUTO p^k^ h[l^ko^] V,-2(,-4W & Ankma^kfhk^' mkb[^g]bfb]bg^ pZl ]^l\kb[^] mh [^ ^__^\mbo^ Z`Zbglm nglmZm^] \^lmh]^l bg \ab\d^g' [nm ]^mZbe^] ]ZmZ p^k^ ghm lahpg V,-2W) Dgm^k^lmbg`er' Zfb]Zgm^e pZl _hng] mh [^ kZib]er f^mZ[hebl^] mh bml ikbfZkr f^mZ[hebm^' i(#,(]bf^mareZfbgh ^marebfbgh$ Zgbebg^ #]

\Znl^] [r /# R[SHXOIUOJKY ' /# J[UJKTGRK Zg] :# GSKXOIGT[Y Zl p^ee Zl Z`Zbglm 3# \KXSOI[RGXOY bg ma^ K^hie^âl M^in[eb\ h_ >abgZ V,-2W) Oa^ nl^ h_ ma^ hkZe mZ[e^m pZl \hglb]^k^] mh [^ lZ_^ Zg] hger o^kr eb`am Zg] mkZglb^gm Z]o^kl^ ^__^\ml aZo^ [^^g k^ihkm^] V,.0W) <\nm^ mhqb\bmr Z_m^k hkZe hk bgmkZi^kbmhg^Ze mk^Zmf^gm h_ fb\^ pZl ]^m^kfbg^] pbma Zg G? 0+ h_ 40+ É -+2 f`*d`

Zg] -22 É -2 f`*d`' k^li^\mbo^er) Dg kZml' ma^ hkZe G? 0+ pZl -++, É 24 f`*d`) Hhk^ho^k' kZml aZ] gh ]^m^\mZ[e^ lb]^ ^__^\ml ni mh -0+ f`*d` `bo^g hkZeer hg ,/ \hgl^\nmbo^ ]Zrl bg]b\Zmbg` Z[l^g\^ h_ ehg`(m^kf mhqb\bmr) abgZ ,-4- Z]he^l\^gml Zg] Z]neml #,0(2+ r^Zkl h_ Z`^$ Zg] 344 \abe]k^g #/(,/ r^Zkl h_ Z`^$' pah p^k^ bg_^\m^] pbma lhbe(mkZglfbmm^] a^efbgmal' k^\^bo^] Z lbg`e^ ^gm^kb\(\hZm^] mZ[e^m \hgmZbgbg` /++ f` Zg] -++ f` mkb[^g]bfb]bg^' k^li^\mbo^er) Oa^ mk^Zmf^gm k^lnem^] bg ab`a \nk^ kZm^l Z`Zbglm /# R[SHXOIUOJKY #4+),(40)+ $ Zg] fh]^kZm^(mh(ab`a \nk^ kZm^l Z`Zbglm ahhdphkfl #3-)+(33)/ $ V,./W) Chp^o^k' lbg`e^ hkZe mkb[^g]bfb]bg^ mk^Zmf^gm lahp^] hger ehp \nk^ kZm^l Z`Zbglm ?# ZXOINO[XG V,-2',./(,.1W' hger [Zl^ebg^ Z\mbobmr Z`Zbglm anfZg bgm^lmbgZe mZ^gbZlbl V,.1W Zg] hger 2+)+ ' /+)+ Zg] .1)/ ^__b\Z\r Z`Zbglm ;# \O\KXXOTO ' 1# YOTKTYOY Zg] ># YZKXIUXGROY ' k^li^\mbo^er V,./W) Dgo^lmb`Zmbhgl hg ehll(h_(_ng\mbhg fnmZgml h_ 1# KRKMGTY ' ln``^lm maZm mkb[^g]bfb]bg^ Z\ml Zl Zg Z`hgblm h_ ma^ G(ln[mri^ h_ <>aMl Zg] ma^k^_hk^ laZk^l bml fh]^ h_ Z\mbhg pbma e^oZfblhe^ Zg] irkZgm^e V,.2W) Chp^o^k' k^\^gm ]ZmZ ]^fhglmkZm^ ln[lmZgmbZe ]b__^k^g\^l bg ma^ \hfihlbmbhg h_ <>aMl Zg] ma^bk lnl\^imb[bebmr mh Zgma^efbgmb\l \hfiZkbg` ]b__^k^gm g^fZmh]^l li^\b^l) Dg ma^ [h]r fnl\e^ h_ ;# JKTZGZ[S _hnk ln[mri^l h_ <>aM pbma ]blmbg\m iaZkfZ\heh`b\Ze ikhi^kmb^l aZo^ [^^g b]^gmb_b^] nlbg` ^e^\mkhiarlbheh`r) Oa^ ehll h_ hg^ h_ ma^l^ ln[mri^l #B .0 iN$ pZl Zllh\bZm^] pbma e^oZfblhe^ k^lblmZg\^) =r a^m^kheh`hnl ^qik^llbhg h_ ]b__^k^gm \hf[bgZmbhgl h_ <>aM ln[ngbml bg C# RGK\OY hh\rm^l' _hnk iaZkfZ\heh`b\Zeer ]b__^k^gm mri^l h_ <>aM p^k^ k^\hglmbmnm^]' pab\a Zee lahp^] ^__^\ml bg ma^ ik^l^g\^ h_ mkb[^g]bfb]bg^ [nm ghm Zee bg ma^ ik^l^g\^ h_ e^oZfblhe^' bg]b\Zmbg` maZm mkb[^g]bfb]bg^ fZr lmbee [^ ^__^\mbo^ hg e^oZfblhe^ k^lblmZgm phkfl V4/W) Oa^l^ _bg]bg`l Z`k^^ pbma ma^ lrg^k`blmb\ ^__^\ml h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ maZm aZo^ [^^g k^ihkm^] Z`Zbglm /TI_RUYZUSG IK_RGTOI[S OT \OZXU Zg] OT \O\U pa^k^Zl ZgmZ`hgblmb\ ^__^\ml h_ ma^ lZf^ \hf[bgZmbhg pa^k^ h[l^ko^] Z`Zbglm 6# HGQKXO V,..W# <`Zbg' mabl \e^Zker ]^fhglmkZm^l maZm ma^ ^__^\ml h_ Zm e^Zlm <>aM Z`hgblml aZo^ mh [^ ZgZerl^] hg ^Z\a g^fZmh]^ li^\b^l h_ bgm^k^lm bg]bob]nZeer Zg] maZm 1# KRKMGTY fb`am ghm [^ Z lnbmZ[e^ fh]^e _hk l\k^^gbg` h_ g^p Zgma^efbgmb\l Z\mbg` hg <>aMl)

/, 1NGVZKX &

,)0)- >r\ehh\mZ]^ilbi^imb]^

Dg ,44-' Zgma^efbgmb\ ^__b\Z\r h_ Z g^p :(f^mareZm^] \r\ehh\mZ]^ilbi^imb]^' KA,+--<' pab\a pZl blheZm^] [r H^bcb N^bdZ FZblaZ Gm]' pZl hkb`bgZeer in[ebla^] V,-/W) KA,+--< bl Z _^kf^gmZmbhg ikh]n\m h_ ma^ _ng`nl =UYKRROTOG lii) KA,+--' pab\a pZl _hng] hg ma^ e^Zo^l h_ ma^ ieZgm 1GSKRROG PGVUTOIG ) Oa^ _ng`nl bl h_ ma^ 9_IKROG YZKXOROG mri^' \aZkZ\m^kbl^] [r _hkfbg` g^bma^k l^qnZe ghk Zl^qnZe lihk^l ng]^k \nemnk^ \hg]bmbhgl V,.3W) KA,+--< bl hg^ h_ ^b`am f^f[^kl #KA,+--<(KA,+--C$ h_ Z _Zfber h_ \r\ehh\mZ]^ilbi^imb]^l \hglblmbg` h_ _hnk Zem^kgZmbg` k^lb]n^l h_ :(f^mare(# >$(Zfbgh Z\b]l Zg] _hnk -(ar]khqr(\Zk[hqreb\ Z\b]l [hng] obZ Zfb]^ Zg] ^lm^k ebgdZ`^ V,.3W) Oa^ _^kf^gmZmbhg ikh]n\ml KA,+--<(C Zk^ lrgma^lbl^] [r ma^ ghgkb[hlhfZe :(f^mare(\r\ehh\mZ]^ilbi^imb]^ lrgma^mZl^ hk KA,+--(lrgma^maZl^' pab\a pZl blheZm^] Zg] \aZkZ\m^kbl^] _khf =UYKRROTOG lii) KA,+-- V,.4W) Dg \hfiZkblhg mh KA,+--=(C' KA,+--< pZl lb`gb_b\Zgmer ab`a^k ^__b\Z\bhnl Z`Zbglm /YIGXOJOG MGRRO bg \ab\d^g V,-/W Zg] pZl eZm^k ln\\^ll_neer m^lm^] _hk g^fZmb\b]Ze ^__b\Z\r Z`Zbglm Z pb]^ kZg`^ h_ g^fZmh]^l bg Z oZkb^mr h_ ahlml' bg\en]bg` /TMOUYZXUTM_R[Y IGTZUTKTYOY V,/+W' :# HXGYOROKTYOY V,/,W Zg] ># XGZZO V,/-W bg kZml' /TMOUYZXUTM_R[Y IUYZGXOIKTYOY V,/.W' 6# HGQKXO V,//W Zg] bgm^lmbgZe lmZ`^l h_ ?# YVOXGROY V,/0W bg fb\^' 6# IUTZUXZ[Y ' ;YZKXZGMOG UYZKXZGMO Zg] ?# IUR[HXOLUXSOY bg cbk]l V,/1W' /# IGTOT[S bg ]h`l' \rZmahlmhf^l bg ahkl^l' 6# IUTZUXZ[Y Zg] ?# IUR[HXOLUXSOY bg la^^i Zl p^ee Zl 2OIZ_UIG[R[Y \O\OVGX[Y bg \Zmme^ V,/-W) Chp^o^k' fb`kZmbg` lmZ`^l h_ :# HXGYOROKTYOY V,/,W' ^g\rlm^] fnl\e^ lmZ`^l h_ ?# YVOXGROY V,/0W Zl p^ee Zl \^k^[kZe lmZ`^l /# IGTZUTKTYOY V,/+W p^k^ e^ll hk ghm Zm Zee Z__^\m^] [r mk^Zmf^gml pbma KA,+--<' ln``^lmbg` maZm bm aZl Z ehp lrlm^fb\ [bhZoZbeZ[bebmr bg ma^ ahlm) Oh bg\k^Zl^ lhen[bebmr Zg] mh bfikho^ [bhZoZbeZ[bebmr Z kZg`^ h_ ]^kboZmbo^l p^k^ lrgma^lbl^]' k^lnembg` bg ^fh]^ilb]^' Z l^fb(lrgma^mb\ ]^kboZmbo^ h_ KA,+--<' \aZkZ\m^kbl^] [r mph Z]]bmbhgZe fhkiahebg^ kbg`l bg ma^ VGXG(ihlbmbhg h_ ^Z\a h_ ma^ mph # =$(ia^greeZ\mb\ Z\b]l) =Zl^] hg ma^ bfikho^] Zmmkb[nm^l' ^fh]^ilb]^ lahpl' [^lb]^l ma^ ^__b\Z\r ikh_be^ f^gmbhg^] _hk KA,+--<' ab`a^k ^__b\Z\r Z`Zbglm \^k^[kZe lmZ`^l h_ /# IGTZUTKTYOY Zg] fnl\e^ lmZ`^l h_ ?# YVOXGROY V,.3W Zg] pZl _hng] mh [^ ab`aer ^__^\mbo^ Z`Zbglm 6KZKXGQOY YV[SUYG V,/2W Zg] ?# S[XOY V,/3',/4W bg fb\^' /KR[XUYZXUTM_R[Y GHYZX[Y[Y V,0+W' bffZmnk^ Zg] fZmnk^ /# Z[HGKLUXSK V,0,W Zl p^ee Zl ?# RKUTOTG Zg] ?# IGZO V,0-W bg \Zml' bffZmnk^ Zg] fZmnk^ /# IGTOT[S V,0.W' bffZmnk^ Zg] fZmnk^ ?# RKUTOTG Zg] ?# IGTOY V,0/W' eZkoZe' ik^Z]nem Zg] fZmnk^ Z]nem lmZ`^l h_ ?# \[RVOY V,00',01W' Zg] bffZmnk^ Zg] fZmnk^ @# YZKTUIKVNGRG V,0.W bg ]h`l) Dm pZl Zelh _hng] mh [^ ^__b\Z\bhnl Z`Zbglm Z oZkb^mr h_ g^fZmh]^l h_ k^imbe^l #bg\en]bg`

/- 5KTKXGR 7TZXUJ[IZOUT

`^\dhl' ebsZk]l' lgZd^l Zg] mnkme^l$ V,/3W Zl p^ee Zl l^o^kZe g^fZmh]^l h_ ahkl^l Zg] knfbgZgml #_hk k^ob^p l^^ V,.3W$) Dgm^k^lmbg`er' bg 9GYZUS_Y IU[ING ^fh]^ilb]^ pZl Zelh _hng] mh [^ ab`aer ^__^\mbo^ Z`Zbglm mabk] Zg] _hnkma lmZ`^ eZkoZ^ Zl p^ee Zl ik^Z]nem phkfl h_ /IGTZNUINKORUTKSG \OZKGK ' _Zbker ^__^\mbo^ Z`Zbglm ma^l^ lmZ`^l h_ 8OZUSUYUOJKY YOMSUJUTZOY [nm ghm ^__^\mbo^ Z`Zbglm ma^ lZf^ lmZ`^l h_ 0# SGRG_O ) Chp^o^k' e^o^el h_ fb\kh_beZkZ^fbZ p^k^ `^g^kZeer Zg] lb`gb_b\Zgmer k^]n\^] pa^g mk^Zmbg` Z`Zbglm Z]nem phkfl V,02',03W) NbfbeZk _bg]bg`l p^k^ h[l^ko^] [r Ohpglhg KZ GR# V,04W' pa^k^ ^fh]^ilb]^ pZl ^__^\mbo^ Z`Zbglm Z]nem ;TINUIKXIG M[ZZ[XUYG OT \OZXU Zg] Z`Zbglm ;TINUIKXIG ROKTGROY fb\kh_beZkbZ^ bg Zg OT \O\U fhnl^(fh]^e) =nm ma^ lZf^ Znmahkl k^ihkm^] maZm ^fh]^ilb]^ pZl fn\a e^ll ihm^gm Z`Zbglm 0X[MOG VGNGTMO ' ]^fhglmkZmbg` maZm ma^ ^__^\m h_ Zgma^efbgmb\l \Zg ]b__^k Zfhg` ^o^g \ehl^er k^eZm^] _beZkbZe li^\b^l' _hk ngdghpg k^Zlhgl V20W) Dg `^g^kZe' ^fh]^ilb]^ pZl k^ihkm^] mh [^ h_ ehp mhqb\bmr Zg] ^qab[bml gh `^ghmhqb\ ikhi^kmb^l) h) Gm]) _be^] Z iZm^gm _hk ^fh]^ilb]^ bg ,44. V,1+W) @fh]^ilb]^ bg \hf[bgZmbhg pbma ikZsbjnZgm^e pZl bgmkh]n\^] bgmh ma^ fZkd^m [r =Zr^k C^Zema>Zk^' ]boblbhg

[b\n\neebg^ ]h^l ghm Z\m Zl Z B<=< < ZgmZ`hgblm bg /# Y[[S pab\a k^]n\^l ma^ lniihkm h_ ma^

/. 1NGVZKX &

arihma^lbl maZm \r\ehh\mZ]^ilbi^imb]^l Z\m hg B<=< < \aZgg^el V,10W) Chp^o^k' _nkma^k

^ob]^g\^ _hk Zg ^fh]^ilb]^ B<=< <(k^\^imhk bgm^kZ\mbhg pZl `bo^g [r ma^ ZgZerlbl h_ mph 1# KRKMGTY fnmZgm lmkZbgl) Dg 1# KRKMGTY g^nkhfnl\neZk cng\mbhg' Z lbg`e^ `^g^' [TI").'

^g\h]^l _hk B<=< < k^\^imhkl) 1# KRKMGTY [TI"). ehll(h_(_ng\mbhg fnmZgml p^k^ lahpg mh [^

\hfie^m^er k^lblmZgm mh ma^ l^e^\mbo^ B<=< < k^\^imhkl Z`hgblm fnl\bfhe Zg] Zelh lb`gb_b\Zgmer e^ll lnl\^imb[e^ mh ^fh]^ilb]^) =r k^bgmkh]n\bg` ?# IGTOY ng\(/4 bgmh [TI"). ]^_b\b^gm 1# KRKMGTY ' fnl\bfhe Zg] ^fh]^ilb]^ l^glbmbobmr p^k^ _neer k^l\n^] V,11W) =r nlbg` Z KA,+--< eb`Zg] bffnghl\k^^gbg` h_ Z 6# IUTZUXZ[Y \?I< eb[kZkr' Z k^\^imhk #C>,,+(M$ lbfbeZk mh ma^ fZffZebZg B(ikhm^bg \hnie^] k^\^imhk eZmkhiabebg Zg] ma^ 1# KRKMGTY Ghg\nkk^gmer' F>IH<(, Zg] NGJ(, k^l\n^ ma^ ia^ghmri^ bg eh\hfhmbhg h_ ma^ pbe] mri^ bg Z \hglblm^gm pZr' ln``^lmbg` maZm ma^ Z__bgbmr h_ ^fh]^ilb]^ bl ab`aer li^\b_b\ mh ma^ g^fZmh]^ NGJ(, \aZgg^e Zg] bg]b\Zmbg` maZm ma^ mhqb\bmr bl li^\b_b\ mh g^fZmh]^l V,2.W) @e^\mkhiarlbheh`b\Ze ^qi^kbf^gml ikhob]^] _nkma^k bglb`am bg ma^ bgoheo^f^gm h_ NGJ(, bg ma^

// 5KTKXGR 7TZXUJ[IZOUT fh]^ h_ Z\mbhg h_ ^fh]^ilb]^) >nkk^gm \eZfi lmn]b^l lahp^] maZm ^fh]^ilb]^ \Znl^] lehp \Ze\bnf( Zg] ihmZllbnf(]^i^g]^gm ari^kiheZkblZmbhg V,2.W Zg] fhk^ k^\^gmer' ohemZ`^ \eZfi ^qi^kbf^gml hg /# Y[[S fnl\e^ _eZil lahp^] maZm ^fh]^ilb]^ bg]n\^] lehp Z\mboZmbhg h_ \Ze\bnf ]^i^g]^gm Zg] ohemZ`^(Z\mboZm^] NGJ(,(ebd^ ihmZllbnf \aZgg^el) NmbfneZmbhg h_ ikhm^bg dbgZl^ > #KF>$ Zg] IJ iZmapZrl ^gaZg\^] ma^l^ ^__^\ml V,2/W) Oa^l^ k^lneml e^Z] mh Z fh]^e ik^l^gm^] [r Fk{\d^g KZ GR# V,.3W5 < iZmapZr Z\mboZm^] [r Z B(ikhm^bg(\hnie^] k^\^imhk' ln\a Zl G fb`am fh]neZm^ ^fh]^ilb]^(bg]n\^] Z\mboZmbhg h_ NGJ(, [r ^)`) \aZg`bg` ma^ ohemZ`^( hk \Ze\bnf(]^i^g]^g\r hk ma^ \hg]n\mZg\^ h_ ma^ \aZgg^e ]n^ mh iahliahkreZmbhg h_ NGJ(,) < fh]^e h_ ma^ \nkk^gmer ln``^lm^] \hfie^q fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l bl `bo^g bg Ab`) ,(-)

9WU& )%*& Hh]^e _hk ma^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l #mZd^g _khf V,.3W$) Oa^ \Zkmhhg ab`aeb`aml ma^ fhlm ebd^er l\^gZkbh' bg pab\a ]bk^\m Z\mboZmbhg h_ NGJ(, Zg] B<=< < [r \r\ehh\mZ]^ilbi^imb]^l bl lahpg) G) Dg \hgmkZlm mh G bl Zelh bgoheo^] bg mabl fh]neZmbhg bg ma^ fhmhk g^nkhg*[h]r pZee fnl\neZmnk^ \bk\nbm) <]]bmbhgZe #hkiaZg$ B(ikhm^bg(\hnie^] k^\^imhkl' pab\a fb`am [^ Z[e^ mh fh]neZm^ ma^ ^__^\ml h_ ^fh]^ilb]^ bg iZkmb\neZk hg ma^ [h]r fnl\e^l' Zk^ Zelh lahpg) Oa^ iZmapZr e^Z]bg` mh _Z\bebmZm^] Z\mboZmbhg h_ NGJ(, \aZgg^el bg k^lihgl^ mh IJ bl \nkk^gmer frlm^kbhnl Zg] k^jnbk^l _nkma^k ^qi^kbf^gmZe ZiikhZ\a^l)

/0 1NGVZKX &

Chp^o^k' bm aZl [^^g ]^l\kb[^] ik^obhnler' maZm ma^ iarenf I^fZmh]Z bl ab`aer ]bo^kl^ Zg] maZm hkmaheh`hnl `^g^l h_ ^o^g \ehl^er k^eZm^] g^fZmh]^ li^\b^l ghm g^\^llZkber ^g\h]^ _hk ikhm^bgl maZm lahp ma^ lZf^ iarlbheh`b\Ze ikhi^kmb^l bg\en]bg` ma^ Z[l^g\^ hk ma^ ik^l^g\^ h_ ]kn` bgm^kZ\mbhgl) =^_hk^ lmZkmbg` mabl ikhc^\m' NGJ(, aZl hger [^^g b]^gmb_b^] bg ma^ \eZ]^ Q g^fZmh]^l 1# KRKMGTY! /# IGTOT[S ' 1# UTIUVNUXG Zg] 6# IUTZUXZ[Y Zg] ma^ \eZ]^ DDD Zl\Zkb]l /# Y[[S ' <# KW[UX[S Zg] ?# IGTOY V,.3W) Oanl' bm bl h_ ^ghkfhnl bfihkmZg\^ mh \a^\d _hk ma^ ik^l^g\^ h_ NGJ(, bg \eZ]^ DDD _beZkbZ^ Zl p^ee Zl \eZ]^ D mkb\ah\^iaZeb]l lbg\^ [hma h_ ma^l^ `khnil \hgmZbg iZkZlbmb\ g^fZmh]^l h_ fZchk bfihkmZg\^)

,)0). Nibkhbg]he^l

KZkZa^kjnZfb]^ pZl ma^ _bklm \hfihng] h_ ma^ libkhbg]he^ \eZll maZm pZl Zmmkb[nm^] mh aZo^ Zgma^efbgmb\ ^__b\Z\r) Dm bl Zg hqbg]he^ ZedZehb] f^mZ[hebm^ h_ aMl bg /# Y[[S ) M^\^gmer =nqmhg KZ GR# V4/W in[ebla^] ]ZmZ hg ma^ a^m^kheh`hnl ^qik^llbhg h_ ]b__^k^gm \hf[bgZmbhgl h_ <>aM ln[ngbml h_ /1 5KTKXGR 7TZXUJ[IZOUT

;# JKTZGZ[S bg C# RGK\OY hh\rm^l' lahpbg` maZm ]^kjnZgm^e Z\ml Zl \hfi^mbmbo^ [bg]^k bg ma^ ik^l^g\^ ma^ e^oZfblhe^ hg hg^ ln[mri^ h_ <>aM #PI>(-4ÖPI>1.ÖPI>.3(<>M3$' [nm Zl Z g^`Zmbo^ Zeehlm^kb\ fh]neZmhk bg ma^ ik^l^g\^ h_ irkZgm^e hg Zghma^k k^\^imhk ln[mri^ \hfihl^] h_ PI>(-4' PI>(1. Zg] PI>(.3$) Nbg\^ ]^kjnZgm^e pZl _hng] mh [^ Z ihm^gm ZgmZ`hgblm h_ [hma ln[mri^l' bm bl ln``^lm^] [r =nqmhg KZ GR# V4/W maZm ]^kjnZgm^e \hne] lmbee [^ Z\mbo^ Z`Zbglm e^oZfblhe^ k^lblmZgm g^fZmh]^l' Zllh\bZm^] pbma k^]n\^] <>M(3 ^qik^llbhg)

,)0)/

FZfbgldr KZ GR# V,--W _bklm k^ihkm^] hg ma^ lrgma^mb\ Zgma^efbgmb\ ]kn` \eZll M(-.) < eZk`^ ikhihkmbhg h_ 1# KRKMGTY lmkZbgl k^lblmZgm mh fhg^iZgm^e lahp^] mkng\Zmbhgl h_ ma^ ik^]b\m^] <>M(-.) Chp^o^k' ma^l^ phkfl lahp^] gh ho^km ia^ghmri^ [^lb]^l fhg^iZgm^e k^lblmZg\^ V,--W ihm^gmbZeer lniihkmbg` kZib] l^e^\mbhg _hk k^lblmZg\^ Z`Zbglm fhg^iZgm^e) Oph _neer k^lblmZgm Zg] hg^ e^ll lnl\^imb[e^ blheZm^ h_ 6# IUTZUXZ[Y p^k^ h[mZbg^] [r OT \OZXU Zg] OT \O\U l^e^\mbhg' k^li^\mbo^er) aM ln[_Zfber ?@B(.) Dgm^k^lmbg`er' 1# KRKMGTY eZ\dbg` ?@N(- Zk^ ghm k^lblmZgm mh fhg^iZgm^e) Chp^o^k' g^qm mh ma^ mkng\Zmbhg*ehll h_ ?@N(-' [hma _neer k^lblmZgm blheZm^l Zelh lahp^] mkng\Zmbhgl bg ma^ 6# IUTZUXZ[Y ahfheh`n^ h_ GIX"'( # 6IGIX"'(6 hk SVZR"& $ V,--W) M^\^gmer Mn_^g^k KZ GR# V,24W k^ihkm^] hg ma^ a^m^kheh`hnl ^qik^llbhg h_ 1# KRKMGTY <>M(-. bg C# RGK\OY hh\rm^l' lahpbg` maZm fhg^iZgm^e Z\ml Zl Zg ]bk^\m Z`hgblm h_ mabl ln[mri^ h_ <>aM) Nnkikblbg`er' fhg^iZgm^e pZl ghm Z[e^ mh Z\m Zl Z ]bk^\m Z`hgblm h_ 6# IUTZUXZ[Y ?@B(.*?@N(- k^\^imhkl a^m^kheh`hnler ^qik^ll^] bg C# RGK\OY hh\rm^l) /2 1NGVZKX &

Chp^o^k' Z\mboZmbhg h_ ma^l^ \aZgg^el [r \ahebg^ pZl ln[lmZgmbZeer ^gaZg\^] [r fhg^iZgm^e' ln``^lmbg` maZm fhg^iZgm^e bl Z mri^ DD ihlbmbo^ Zeehlm^kb\ fh]neZmhk h_ 6# IUTZUXZ[Y ?@B(.*?@N(- \aZgg^el V,3+W) ?^libm^ ma^ _Z\m maZm ma^ bgmkh]n\mbhg h_ Uheobq Ä hg ma^ fZkd^m bl e^ll maZg _bo^ r^Zkl Z`h' _bklm k^ihkml h_ k^lblmZgm blheZm^l h_ ?# IOXI[SIOTIZG Zg] ?# IUR[HXOLUXSOY aZo^ [^^g in[ebla^] V,,.W)

,)0)0 OabZsheb]^l

Oa^ \eZll h_ mabZsheb]^l' pab\a ^ll^gmbZeer \hgmZbgl gbmZshqZgb]^ ]^kboZmbo^l' pZl hkb`bgZeer in[ebla^] bg ma^ ,42+l V,-0W) Oa^ iZk^gm \hfihng] gbmZshqZgb]^ #-(Z\^mrehehqr( :(#0(gbmkh(-( mabZshere$[^gsZfb]^$ pZl bgbmbZeer ]^o^ehi^] Zl Z o^m^kbgZkr ]kn` mZk`^mbg` bgm^lmbgZe \^lmh]^l V,-0W) IbmZshqZgb]^ bl Z [khZ](li^\mknf ]kn` _hk ma^ mk^Zmf^gm h_ `Zlmkhbgm^lmbgZe bg_^\mbhgl bg\en]bg` ikhmhshZg iZkZlbm^l' g^fZmh]^l Zg] \^lmh]^l' ZgZ^kh[b\ [Z\m^kbZ Zl p^ee Zl obknl^l V,3,W) IbmZshqZgb]^ pZl \hff^k\bZebl^] _hk ma^ mk^Zmf^gm anfZg ikhmhshZg bg_^\mbhgl #1X_VZUYVUXOJO[S VGX\[S Zg] 5OGXJOG OTZKYZOTGROY $ V,3,(,3.W) Oa^kZi^nmb\ Z\mbobmr Z`Zbglm a^efbgmal pZl ]^fhglmkZm^] _hk ma^ g^fZmh]^l /# J[UJKTGRK ' /# R[SHXOIUOJKY! 3# \KXSOI[RGXOY ' >ZXUTM_RUOJKY lii) Zg] ?# ZXOINO[XG Zl p^ee Zl _hk ma^ ieZmra^efbgmal 4# NKVGZOIG 6# TGTG! ?# YGMOTGZG Zg] f^mZ\^lmh]^l h_ 3# S[RZORUI[RGXOY Zg] 3# MXGT[RUY[Y #_hk k^ob^p l^^ V,-0',3,W$) Dm aZl [^^g ]^fhglmkZm^] maZm gbmZshqZgb]^ bgab[bml ma^ irknoZm^(_^kk^]hqbg hqbk^]n\mZl^ h_ ikhmhshZgl Zg] ZgZ^kh[b\ [Z\m^kbZ) Chp^o^k' bm bl ghm \e^Zk b_ gbmZshqZgb]^ mZk`^ml ikhmhshZg iZkZlbm^l obZ _nkma^k iZmapZrl V,3,W) Oa^ fh]^ h_ Z\mbhg Z`Zbglm a^efbgmal bl ghm \hfie^m^er ng]^klmhh]) Plbg` 1# KRKMGTY fnmZ`^g^lbl l\k^^gbg`' bm aZl [^^g lahpg maZm IbmZshqZgb]^ bgm^kZ\ml pbma Ben>el # G\X"&) V,3/W)

,)0)1 ?kn` \hf[bgZmbhgl

?kn` \hf[bgZmbhgl Zk^ ihp^k_ne mhhel bg anfZg ]bl^Zl^ \hgmkhe pbma gnf^khnl \hf[bgZmbhgl nl^] bg Zgmb\Zg\^k \a^fhma^kZir V,30W Zg] ma^ Zgmb(CDQ mkbie^ ma^kZir \hf[bgbg` bg]bgZobk' sb]hon]bg^ Zg] eZfbon]bg^ V,31W Zl ikhfbg^gm ^qZfie^) Chp^o^k' bg o^m^kbgZkr iZkZlbmheh`r ma^ nl^ h_ Zgma^efbgmb\ ]kn` \hf[bgZmbhgl bl Zelh \hglb]^k^] mh [^ Z ln\\^ll_ne mk^Zmf^gm lmkZm^`r V,32(,34W) =Zlb\Zeer' ]kn` \hf[bgZmbhgl \Zg [^ nl^] _hk mak^^ ikhihl^l #b$ mh bg\k^Zl^ ma^ Zgma^efbgmb\ li^\mknf # K#M# g^fZmb\b]Ze ]kn` ienl \^lmh]b\b]Ze ]kn`l$ #bb$ mh bfikho^ ma^

/3 5KTKXGR 7TZXUJ[IZOUT

^__b\Z\r h_ ma^ k^li^\mbo^ ]kn`l # K#M# Z[Zf^\mbg Zg] ]^kjnZgm^e bg NmZkm^\m Ä V,4+W$ #bbb$ mh ]^\^e^kZm^ ma^ ]^o^ehif^gm h_ k^lblmZg\^ V,34W) >hf[bgZmbhgl h_ fZ\kh\r\eb\ eZ\mhg^l \hf[bg^] pbma ]hqr\r\ebg^ p^k^ _hng] mh aZo^ e^maZe ^__^\m hg fZ\kh_beZkbZ^ h_ 2# OSSOZOY ' pa^k^Zl mk^Zmf^gml pbma fZ\kh\r\eb\ eZ\mhg^l hger k^lnem bg bg_^\ng]bmr h_ ma^ Z]nem _^fZe^l V,4,',4-W) HZma^fZmb\Ze fh]^eebg` k^o^Ze^] Zek^Z]r bg ma^ fb] ,44+l maZm nl^ h_ Zgma^efbgmb\ ]kn` \hf[bgZmbhgl fb`am lb`gb_b\Zgmer ]^eZr ma^ hgl^m h_ k^lblmZg\^ V,4.W) Dg ,444' =^Z\a KZ GR# V,4/W in[ebla^] ma^ lb`gb_b\Zgmer ab`a^k ^__b\Z\r h_ Ze[^g]Zshe^ ienl bo^kf^\mbg \hf[bgZmbhg Z`Zbglm anfZg B# HGTIXULZO bg_^\mbhgl Zg] lhbe(mkZglfbmm^] a^efbgmahlbl bg\en]bg` ?# ZXOINO[XG bg \hfiZkblhg mh ma^ k^li^\mbo^ lbg`e^ ]kn` ^__b\Z\b^l bg Z kZg]hfbl^]' ieZ\^[h \hgmkhee^] mkbZe) =Zl^] hg ma^l^ _bg]bg`l' Z lb`gb_b\Zgm gnf[^k h_ Zgma^efbgmb\ ]kn` \hf[bgZmbhgl p^k^ ^oZenZm^] mh mk^Zm anfZg a^efbgma bg_^\mbhgl #K#M# V,40(,42W$) Ankma^kfhk^' ]kn` \hf[bgZmbhgl Zk^ Zelh ^oZenZm^] _hk ma^bk \hf[bgZmhkr ^__^\ml Z`Zbglm g^fZmh]^l bg ^Zker l\k^^gbg` iaZl^l # K#M# bg OT \OZXU ZllZrl$' mh b]^gmb_r ihm^gmbZe Z]]bmbo^ hk ^o^g lrg^k`blmb\ ^__^\ml bg Z ahlm bg]^i^g]^gm ^gobkhgf^gm #^)`) V,..',3/',43',44W$)

/4 1NGVZKX &

)&. 4W[a O\R ]cbZW\S ]T bVWa bVSaWa

Oa^ nk`^gm ]^fZg] _hk g^p Zgma^efbgmb\l bl h[obhnl) Dg o^m^kbgZkr f^]b\bg^ ma^ lbmnZmbhg bl ]b\ahmhfhnl) =^lb]^l ma^ ik^o^gmbhg h_ a^Zkmphkf ]bl^Zl^ bg ]h`l' pab\a lhe^er k^eb^l hg ma^ nl^ h_ fZ\kh\r\eb\ eZ\mhg^l' ma^ \nkk^gmer ZoZbeZ[e^ kZg`^ h_ Zgma^efbgmb\l mh mk^Zm g^fZmh]^ bg_^\mbhgl h_ \hfiZgbhg ZgbfZel bl Z]^jnZm^) Dg \hgmkZlm' ma^ bg\k^Zlbg` h\\nkk^g\^ Zg] lik^Z] h_ k^lblmZgm g^fZmh]^ ihineZmbhgl h_ \Zmme^' la^^i' `hZm Zg] ahkl^l k^lneml bg Z o^kr ]b__b\nem lbmnZmbhg bg ma^l^ ahlm li^\b^l) Oa^ lbmnZmbhg bg anfZg f^]b\bg^ bl Zelh \aZee^g`bg`) M^\hff^g]^] [r ma^ RCJ' ma^ eblm h_ ^ll^gmbZe f^]b\bg^l \hgmZbgl hger _hnk ]kn`l _hk ma^ mk^Zmf^gm h_ `Zlmkhbgm^lmbgZe g^fZmh]^ bg_^\mbhgl Zg] hger mak^^ \a^fhma^kZi^nmb\Ze ln[lmZg\^l _hk ma^ mk^Zmf^gm h_ _beZkbhlbl) Nbg\^ ma^ ]kn`l _hk ma^ mk^Zmf^gm h_ `Zlmkhbgm^lmbgZe g^fZmh]^l [^ehg` mh hger mph Zgma^efbgmb\ \eZll^l' gZf^er Ze[^g]Zshe^ Zg] f^[^g]Zshe^ mh ma^ [^gsbfb]Zshe^l Zg] e^oZfblhe^ Zg] irkZgm^e mh ma^ \ahebg^k`b\ ]kn`l' ma^ Zkl^gZe bl ^o^g _nkma^k k^]n\^]) Dg Z]]bmbhg' Zee h_ ma^l^ ]kn`l lahp bgln__b\b^gm ^__b\Z\r Z`Zbglm ahhdphkfl Zg] pabiphkf' pa^g Z]fbgblm^k^] Zl fhghma^kZir bg Z lbg`e^ ]hl^) Oa^k^_hk^' ma^ ik^l^gm \nfneZmbo^ ma^lbl _nkma^k ZgZerl^l ma^ ihm^gmbZe h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' mkb[^g]bfb]bg^ Zg] ]

Oa^ _bklm iZkm #\aZim^k -$ Zbf^] hg ma^ bgo^lmb`Zmbhg h_ ma^ ik^obhnler ln``^lm^] \^lmh]b\b]Ze ^__^\ml h_ ma^ Zfbghia^greZfb]bg^l bg Z \hgmkhee^] eZ[hkZmhkr mkbZe) Oa^ lmn]r pZl \hg]n\m^] bg ma^ mahkhn`aer \aZkZ\m^kbl^] Zg] p^ee(^lmZ[ebla^] OT \O\U fh]^e mZk`^mbg` ma^ fhnl^ [be^ ]n\m mZi^phkf 6_SKTURKVOY SOIXUYZUSG bg fb\^) Oabl fh]^e bl p^ee Z\\^im^] Zg] \hglb]^k^] Zl Z `hh] bg]b\Zmhk _hk ma^ ^oZenZmbhg h_ \^lmh]b\b]Ze ^__^\ml) ?n^ mh ma^ \hgmkZ]b\mhkr ebm^kZmnk^ hg \hf[bgZmhkr ^__^\ml h_ e^oZfblhe^ ienl mkb[^g]bfb]bg^' ma^ \^lmh]b\b]Ze ihm^g\b^l h_ Zfbghia^greZfb]bg^l p^k^ bgbmbZeer \hfiZk^] mh ma^ ihm^g\r h_ e^oZfblhe^' _heehp^] [r ma^ ^qZfbgZmbhg h_ \hf[bgZmhkr ^__^\ml h_ e^oZfblhe^ ienl mkb[^g]bfb]bg^)

Oa^ l^\hg] iZkm #\aZim^k .$ Zbf^] hg ma^ ^oZenZmbhg h_ ma^ g^fZmb\b]Ze li^\mkZ h_ ma^ Zfbghia^greZfb]bg^l Zg] \r\ehh\mZ]^ilbi^imb]^l [r \hfiZkbg` ma^bk ihm^g\r Z`Zbglm g^fZmh]^l OT \OZXU ) <`Zbg' e^oZfblhe^ l^ko^] Zl k^_^k^g\^ ]kn`) >hglb]^kbg` ma^ ]bo^klbmr h_ ma^ iarenf I^fZmh]Z' ma^ ZllZrl p^k^ i^k_hkf^] Z`Zbglm ma^ \eZ]^ D g^fZmh]^ ?# YVOXGROY Zg] ma^ \eZ]^ Q kZm ahhdphkf :# HXGYOROKTYOY ) Oa^k^[r ma^ ^__b\Z\r Z`Zbglm mph li^\b^l pbma

0+ 5KTKXGR 7TZXUJ[IZOUT fZqbfZe iareh`^g^mb\ ]blmZg\^ pZl ^qZfbg^]) Oh _nkma^k bg\k^Zl^ ma^ ]bo^klbmr' G, h_ ?# YVOXGROY Zl p^ee Zl G. Zg] Z]nem phkfl h_ :# HXGYOROKTYOY p^k^ nl^]) <`Zbg' g^qm mh ma^ ^oZenZmbhg h_ lbg`e^ ]kn`l' \hf[bgZmbhgl h_ Zfbghia^greZfb]bg^l pbma e^oZfblhe^ Zg] h_ Zfbghia^greZfb]bg^l pbma \r\ehh\mZ]^ilbi^imb]^l p^k^ m^lm^])

Oa^ mabk] iZkm #\aZim^k /$ Z]]k^ll^] ma^ mkZgl_^kZ[bebmr _khf Zgma^efbgmb\ OT \OZXU ihm^g\r mh Zgma^efbgmb\ ^__^\ml h[l^ko^] OT \O\U ) Oa^k^_hk^' ma^ eZk`^er nl^] OT \O\U fh]^e :# HXGYOROKTYOY bg kZml pZl nl^]) Oa^ lZf^ fhghma^kZib^l Zl p^ee Zl ]kn` \hf[bgZmbhgl p^k^ ^oZenZm^] Zg] \hfiZk^] mh ma^ ik^obhnler \hee^\m^] OT \OZXU ]ZmZ) Pg^qi^\m^] ]b__^k^g\^l bg ma^ ihm^g\r h_ ma^ mph Zfbghia^greZfb]bg^l mkb[^g]bfb]bg^ Zg] ]

Oa^ _hnkma iZkm #\aZim^k 0$ Zbf^] hg ma^ ^oZenZmbhg h_ ma^ ihm^g\r h_ Zfbghia^greZfb]bg^l Zg] \r\ehh\mZ]^ilbi^imb]^l bg Z mkb\ankhlbl fh]^e) Nbg\^ ?XOIN[XOY #\eZ]^ D$ bl ma^ ]hl^( ebfbmbg` `Zlmkhbgm^lmbgZe g^fZmh]^ `^gnl _hk Zefhlm Zee \nkk^gmer nl^] Zgma^efbgmb\ ]kn` \eZll^l bg ]h`l' lpbg^ Zg] anfZgl' Zll^llf^gm h_ ma^ ihm^g\r Z`Zbglm mabl `^gnl bl h_ fZchk bfihkmZg\^) Oh bgo^lmb`Zm^ Zg] \hfiZk^ ma^ Zgma^efbgmb\ ^__b\Z\r h_ \hfihng]l Z`Zbglm pabiphkfl' ma^ ?# S[XOY fhnl^ fh]^e bl ab`aer lnbmZ[e^) Oa^k^_hk^' ma^ ?# S[XOY eb_^ \r\e^ pZl ^lmZ[ebla^] bg fb\^) <_m^k ]^mZbe^] iZkZlbmheh`b\Ze \aZkZ\m^kblZmbhg h_ ma^ iZkZlbm^ ahlm bgm^kZ\mbhg' OT \O\U lmn]b^l bg]bob]nZeer mZk`^mbg` ^Z\a iZkZlbmb\ eb_^ \r\e^ lmZ`^ p^k^ i^k_hkf^])

Oa^ _b_ma iZkm #\aZim^k 1$ Zbf^] hg ma^ b]^gmb_b\Zmbhg Zg] \aZkZ\m^kblZmbhg h_ ma^ \Ze\bnf( Z\mboZm^] Zg] ohemZ`^(]^i^g]^gm ihmZllbnf \aZgg^e NGJ(,' pab\a bl ikhihl^] mh [^ ma^ ]bk^\m mZk`^m h_ ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^) NGJ(, pZl Zek^Z]r ]^l\kb[^] bg \eZ]^ Q g^fZmh]^l) ?^libm^ ik^l^g\^ h_ iZkZlbmb\ g^fZmh]^l h_ fZchk bfihkmZg\^ _hk anfZg Zg] ZgbfZe a^Zema' NGJ(, aZl ghm [^^g bgo^lmb`Zm^] bg \eZ]^ DDD Zg] \eZ]^ D g^fZmh]^l) NGJ(, pZl ma^k^_hk^ b]^gmb_b^] Zg] \ehg^] _khf mak^^ _beZkbZ^ #\eZ]^ DDD$ Zg] ?# S[XOY #\eZ]^ D$' l^kobg` _hk Z iareh`^g^mb\ ZgZerlbl h_ NGJ(,) <]]bmbhgZeer' NGJ(, \aZgg^el p^k^ a^m^kheh`hnler ^qik^ll^] bg C# RGK\OY hh\rm^l mh bgo^lmb`Zm^ ma^ ^__^\ml h_ \r\ehh\mZ]^ilbi^imb]^l hg ma^l^ \aZgg^el)

0, 1NGVZKX &

)&/ ESTS`S\QSa

,) Cbiih\kZm^l' ,3.4' J^nok^l \hfiewm^l' GZmmk^l @ #OkZgle)$ E) =) =Zbeebwk^' KZkbl) -) Okhfihndbl >' B^kfZg Q' AZeZ`Zl H@' -++2' Akhf ma^ khhml h_ iZkZlbmheh`r5 Cbiih\kZm^l" _bklm l\b^gmb_b\ h[l^koZmbhgl bg a^efbgmaheh`r) E KZkZlbmhe 4.' 42+(42-) .) h) FB)' Nmnmm`Zkm) 1) 1# KRKMGTY N^jn^g\bg` >hglhkmbnf' ,443' B^ghf^ l^jn^g\^ h_ ma^ g^fZmh]^ 1# KRKMGTY 5 Z ieZm_hkf _hk bgo^lmb`Zmbg` [bheh`r) N\b^g\^ -3-' -+,-(-+,3) 2) Bb[[hgl GH' -++-' B^g^kZe Jk`ZgblZmbhg' Dg5 G^^ ?G #@])$' Oa^ [bheh`r h_ g^fZmh]^l) >M> Kk^ll' =h\Z MZmhg) 3) H^e]Ze =C' ?^[^gaZf IE' ?^ G^r K' ?^ G^r DO' QZg_e^m^k^g EM' Qb^klmkZ^m^ ' =eZqm^k HG' Mh`^kl eZ]^l) Hhe =bhe @ohe -.' ,24-(,3++) ,+) =eZqm^k HG' ?^ G^r K' BZk^r EM' Gbn GS' N\a^e]^fZg K' Qb^klmkZ^m^ <' QZg_e^m^k^g EM' HZ\d^r GT' ?hkkbl H' Akbll^ GH' Qb]Z EO' OahfZl RF' ,443' < fhe^\neZk ^ohenmbhgZkr _kZf^phkd _hk ma^ iarenf I^fZmh]Z) IZmnk^ .4-' 2,(20) ,,) ?^ G^r K' -++1' < jnb\d mhnk h_ g^fZmh]^ ]bo^klbmr Zg] ma^ [Z\d[hg^ h_ g^fZmh]^ iareh`^gr) Rhkf=hhd5 ,(3) ,-) >abmphh] =B' >abmphh] H=' ,4..' Oa^ \aZkZ\m^kl h_ Z ikhmhg^fZmh]^) E KZkZlbmhe -+' ,.+) ,.) >abmphh] =B' ,4.2' < k^obl^] \eZllb_b\Zmbhg h_ ma^ I^fZmh]Z) Dg5 abmphh] =B' ,403' Oa^ ]^lb`gZmbhg h_ h__b\bZe gZf^l h_ ab`a^k mZqZ h_ o^km^[kZm^l) =nee Uhhe Ihf^g\e ,0' 31+(340)

0- 5KTKXGR 7TZXUJ[IZOUT

,0) ' BZk^r EM' MZ__ M<' GZd^ E<' ,442' @ob]^g\^ _hk Z \eZ]^ h_ g^fZmh]^l' Zkmakhih]l Zg] hma^k fhnembg` ZgbfZel) IZmnk^ .32' /34(/4.) ,2) ' -+++' I^fZmh]^ iZkZlbm^l h_ o^km^[kZm^l5 Oa^bk ]^ehif^gm Zg] mkZglfbllbhg) ><=D Kn[eblabg`' RZeebg`_hk]) ,3) H^aeahkg C' -++,' @g\r\ehi^]b\ k^_^k^g\^ h_ iZkZlbmheh`r) Nikbg`^k' =^kebg) ,4) Ehg^l E' -++-' I^fZmh]^ l^gl^ hk`Zgl' Dg5 G^^ ?G #@])$' Oa^ [bheh`r h_ g^fZmh]^l) >M> Kk^ll' =h\Z MZmhg) -+) HZkmbg EH' Knk\^ee E' Mh[^kmlhg M> Kk^ll' =h\Z MZmhg) -,) >hhd <<' =aZk]nkr K' ?^]^gaZf IE' H^e]Ze =CH' =eZqm^k HG' Nf^k]hg BM' ' GZf[la^Z] KE?' Mh`^kl M> Kk^ll' =h\Z MZmhg) -0) G^ng` H>' RbeebZfl KG' =^g^]^mmh <' ' C^ef\d^ FE' nmm^k a^fblmkr -++3) ammi5**ppp)gh[^eikbs^)hk`*gh[^eXikbs^l*\a^fblmkr*eZnk^Zm^l*-++3*5 Ih[^e H^]bZ <=)

0. 1NGVZKX &

.+) HZgsZgbeeZ(Ghivl MC' @oZgl F' =kb]`^ E' -++/' KeZgm ]bl^Zl^l \Znl^] [r g^fZmh]^l' Dg5 >a^g US' >a^g RT' >a^g NT' ?b\dlhg ?R #@]l)$' I^fZmheh`r5 <]oZg\^l Zg] K^kli^\mbo^l Qhe -5 I^Zfmh]^ HZgZ`^f^gm Zg] PmbebsZmbhg) ><=D Kn[eblabg`' RZeebg`_hk]) .,) >hkpbg MH' ,442' @\hghfb\l h_ `Zlmkhbgm^lmbgZe iZkZlbmblf h_ \Zmme^) Q^m KZkZlbmhe 2-' /0,(/02) .-) @i^ >' -++4' Dgm^lmbgZe g^fZmh]^l5 [bheh`r Zg] \hgmkhe) Q^m >ebg Ihkma KZGXOG Z[TJXG bg fhljnbmh^l _khf B^kfZgr) KZkZlbm Q^\mhkl 2' .+) ./) NZllgZn M' Fhag H' ?^f^e^k E' Fhag =' Hnee^k @' Fk{\d^g E' ohg NZflhg( Cbff^elmc^kgZ B' -+,.' Dl 2OXULORGXOG XKVKTY ^g]^fb\ bg ma^ CZo^eeZg] ]blmkb\m bg =kZg]^g[nk`' B^kfZgr: Q^\mhk =hkg^ Uhhghmb\ ?bl ,.' 333(34,) .0) >sZcdZ >' =^\d^k I' Ehlm C' Khii^km N' N\afb]m(>aZgZlbm E' Fkn`^k <' OZggb\a @' -+,/' NmZ[e^ mkZglfbllbhg h_ 2OXULORGXOG XKVKTY g^fZmh]^l' Ihkma^kg B^kfZgr) @f^k` Dg_^\m ?bl -+' .-3(..+) .1) Gnlmb`fZg N' Kkb\aZk] MF' BZssbg^eeb <' BkZgm RI' =hZmbg =<' H\>Zkmar EN' =ZlZg^s HB' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 ma^ ikh[e^f h_ a^efbgmabZl^l) KGhN I^`e Okhi ?bl 1' ^,03-) .2) Fghii N' Nm^bgfZgg K' F^bl^k E' Pmsbg`^k E' -+,-' I^fZmh]^ bg_^\mbhgl5 lhbe( mkZglfbmm^] a^efbgmal Zg] ?XOINOTKRRG ) Dg_^\m ?bl >ebg Ihkma Zg p^ ]^phkf mabl phkfr phke]: =k H^] =nee 0/' /-,(/.-) /,) Q' >hhi^k @N' -+++' Oa^ in[eb\ a^Zema lb`gb_b\Zg\^ h_ ?XOIN[XOY ZXOINO[XG ) KZkZlbmheh`r ,-,' 2.(40) /.) =khhd^k N' =^mahgr E' Chm^s KE' -++/' CnfZg ahhdphkf bg_^\mbhg bg ma^ -,lm \^gmnkr) <]o KZkZlbmhe 03' ,42(-33)

0/ 5KTKXGR 7TZXUJ[IZOUT

//) Nm^ia^glhg GN' GZmaZf H>' Fbghmb NI' Fnks FH' =kb`aZf C' ,44+' Dfikho^f^gml bg iarlb\Ze _bmg^ll h_ F^grZg l\ahhe[hrl bg_^\m^] pbma ahhdphkf' ?XOIN[XOY ZXOINO[XG Zg] /YIGXOY R[SHXOIUOJKY _heehpbg` Z lbg`e^ ]hl^ h_ Ze[^g]Zshe^) OkZgl M Nh\ Okhi H^] Cr` 3/' -22(-3-) /0) NZdmb C' Ihd^l >' C^kmZgmh RN' C^g]kZmgh N' CZee <' =ng]r ?<' NZmhmh' ,444' @ob]^g\^ _hk Zg Zllh\bZmbhg [^mp^^g ahhdphkf bg_^\mbhg Zg] \h`gbmbo^ _ng\mbhg bg Dg]hg^lbZg l\ahhe \abe]k^g) Okhi H^] Dgm C^Zema /' .--(../) /1) Aehp^kl ME' BkZr DN' =Zmm^kl[r N' -+,,' Kabehlhiar Zg] ikbg\bie^l h_ ^gobkhgf^gmZe a^Zema' Dg5 =Zmm^kl[r N #@])$' >eZrÅl aZg][hhd h_ ^gobkhgf^gmZe a^Zema) Nihg Kk^ll' <[bg`]hg) /2) Rhke] C^Zema Jk`ZgbsZmbhg' -+,.' Beh[Ze a^Zema ^lmbfZm^l lnffZkr mZ[e^l5 ?ebg Hb\kh[bhe Dg_^\m ,2' 422(430) 0+) Gnlmb`fZg N' B^e]ah_ K' BkZgm RI' Jl^b(a^fblmkr Rbe^r(Q>C Q^keZ` Bf[C ! >h) FBZ<' R^bga^bf) 00) CZk]^k <' -++-' >a^fhma^kZi^nmb\ ZiikhZ\a^l mh mk^fZmh]^l #^q\^im l\ablmhlhf^l$ Zg] \^lmh]^l5 \nkk^gm e^o^e h_ dghpe^]`^ Zg] hnmehhd) KZkZlbmhe M^l 33' 032(04+)

00 1NGVZKX &

01) F^bl^k E' Pmsbg`^k E' -++4' Ahh]([hkg^ mk^fZmh]bZl^l) >ebg Hb\kh[bhe M^o --5 /11( /3.) 02) >kZb` K' Dmh <' -++2' Dgm^lmbgZe \^lmh]^l) >nkk Jibg Dg_^\m ?bl -+' 0-/(0.-) 03) Hbg ?T' ,44+' >^lmh]^ bg_^\mbhgl bg Fhk^Z) FblZ^g`\ang`aZd >aZi\ab -3' ,-.(,//) 04) ?hkgr K' KkZ^m I' ?^\d^kl I' BZ[kb^e N' -++4' @f^k`bg` _hh]([hkg^ iZkZlbm^l) Q^m KZkZlbmhe ,1.' ,41(-+1) 1+) ?^ieZs^l K' oZg FgZi^g A' N\ap^b`^k <' Jo^k`ZZnp K<' -+,,' Mhe^ h_ i^m ]h`l Zg] \Zml bg ma^ mkZglfbllbhg h_ a^efbgmab\ shhghl^l bg @nkhi^' pbma Z _h\nl hg ^\abgh\h\\hlbl Zg] mhqh\Zkhlbl) Q^m KZkZlbmhe ,3-' /,(0.) 1,) Pmsbg`^k E' F^bl^k E' -++/' N\ablmhlhfbZlbl Zg] lhbe(mkZglfbmm^] a^efbgmabZlbl5 \hffhg ]kn`l _hk mk^Zmf^gm Zg] \hgmkhe) @qi^km Jibg KaZkfZ\hma^k 05 -1.(-30) 1-) Bk^^g[^k` MH' -++0' >Z -& lb`gZeebg`' ohemZ`^(`Zm^] >Z -& \aZgg^el Zg] ikZsbjnZgm^e bg _eZmphkf g^nkhfnl\neZmnk^) KZkZlbmheh`r ,.,' 42(,+3) 1.) ?h^gah__ HE' >bheb ?' Pmsbg`^k E' -++3' KkZsbjnZgm^e5 f^\aZgblfl h_ Z\mbhg' k^lblmZg\^ Zg] g^p ]^kboZmbo^l _hk l\ablmhlhfbZlbl) >nkk Jibg Dg_^\m ?bl -,' 104(112) 1/) GZm^^_ H' UZk`Zk N<' FaZg Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 1' ^,0/4)

01 5KTKXGR 7TZXUJ[IZOUT

2,) Ub^`^e[Zn^k F' Ni^b\a =' HZnl^sZae ?' =hl M' F^bl^k E' Pmsbg`^k E' -+,-' @__^\m h_ lZgbmZmbhg hg lhbe(mkZglfbmm^] a^efbgma bg_^\mbhg5 lrlm^fZmb\ k^ob^p Zg] f^mZ(ZgZerlbl) KGhN H^] 45 ^,++,,1-) 2-) OZrehk HE' Ch^kZn_ <' =h\dZkb^ H' -+,+' GrfiaZmb\ _beZkbZlbl Zg] hg\ah\^k\bZlbl) GZg\^m .21' ,,20(,,30) 2.) KZ]`^mm EE' EZ\h[l^g FC' -++3' GhbZlbl5 <_kb\Zg ^r^ phkf) OkZgl M Nh\ Okhi H^] Cr` ,+-' 43.(434) 2/) Nbfhgl^g K@' JgZiZ ?' -+,,' Kkh`k^ll Zg] \aZee^g`^l bg ma^ ]bl\ho^kr h_ fZ\kh_beZkb\b]Ze ]kn`l) @qi^km M^o hg]^k B<' -++-' >a^fb\Ze \hgmkhe h_ ZgbfZe(iZkZlbm\ g^fZmh]^l' Dg5 G^^ ?G #@])$' Oa^ [bheh`r h_ g^fZmh]^l) >M> Kk^ll' =h\Z MZmhg) 22) H\>Zee ER' B^g\ab >' FkZf^k GC' Bn^kk^kh E' Q^g\h G' -++3' C^Zkmphkf ]bl^Zl^ bg ZgbfZel Zg] anfZgl) <]o KZkZlbmhe 11' ,4.(-30) 23) =khpg ??' Nb]]bjnb NU' FZcb H?' Ahkk^lm^k NB' -+,-' KaZkfZ\heh`b\Ze \aZkZ\m^kbsZmbhg h_ ma^ 6GKSUTIN[Y IUTZUXZ[Y B<=<(`Zm^] \aehkb]^ \aZgg^e' C\h( PI>(/45 fh]neZmbhg [r fZ\kh\r\eb\ eZ\mhg^ Zgma^efbgmb\l Zg] Z k^\^imhk _hk ibi^kZsbg^) Q^m KZkZlbmhe ,30' -+,(-+4) 24) HZkmbg ME' ,430' BZffZ(Zfi[^ee R>' >n\de^k <>>' ,41,' a^f Nh\) 3.' ,21/(,210) 3,) Ohpgl^g] G=' Rbl^ ?N' ,44+' Oa^ lrgma^lbl Zg] \a^fblmkr h_ \^kmZbg Zgma^efbgmb\ [^gsbfb]Zshe^l) KZkZlbmhe Oh]Zr 1' ,+2(,,-) 3-) >Zfi[^ee R>' ,44+' =^gsbfb]Zshe^l5 o^m^kbgZkr nl^l) KZkZlbmhe Oh]Zr 1' ,.+(,..) 3.) HZblhgg^no^ C' Mhllb`ghe EA' <]]h <' Hhchg H' ,430' Job\b]Ze ^__^\ml h_ Ze[^g]Zshe^ bg anfZg Zl\ZkbZlbl' Zg\rehlmhfbZlbl Zg] mkb\ankbZlbl)

02 1NGVZKX &

31) CZk]^k <' -++-' >a^fhma^kZi^nmb\ ZiikhZ\a^l mh g^fZmh]^l5 \nkk^gm dghpe^]`^ Zg] hnmehhd) KZkZlbmhe M^l 33' -2-(-22) 32) <\^o^l E' @kebc ?' HZkmbg^s(HZkZghg M' ,42+' Oa^ f^\aZgblf h_ ma^ iZkZerlbg` Z\mbhg h_ m^mkZfblhe^ hg /YIGXOY lhfZmb\ fnl\e^) =k E KaZkfZ\he .3' 1+-(1+2) 33) hp^ee K' ?Zo^r HE' Na^o]^ N' ,42+' hfiZkZmbo^ g^nkhfnl\neZk [eh\dbg` Z\mbhgl h_ e^oZfblhe^ Zg] irkZgm^e(mri^ Zgma^efbgmb\l hg kZm Zg] `Zlmkhbgm^lmbgZe g^fZmh]^ lhfZmb\ fnl\e^) Ohqb\he aZko^m >G' I^o^n >' -+,-' G^oZfblhe^ k^\^imhkl5 Z l^\hg] ZpZd^gbg`) Ok^g]l KZkZlbmhe -3' -34(-41) 4,) =hnebg O' Bb^e^g H' Mb\afhg] E@' RbeebZfl ?>' KZhe^mmb K' =^ll^k^Zn EG' -++3' @b`am `^g^l Zk^ k^jnbk^] _hk _ng\mbhgZe k^\hglmbmnmbhg h_ ma^ 1GKTUXNGHJOZOY KRKMGTY e^oZfblhe^(l^glbmbo^ Z\^mre\ahebg^ k^\^imhk) Kkh\ IZme <\Z] N\b ,+0' ,304+(,3040) 4-) I^o^n >' >aZko^m >G' AZnobg <' >hkm^m E' =^^\a MI' >Z[Zk^m E' -+,+' B^g^mb\ ]bo^klbmr h_ e^oZfblhe^ k^\^imhk ln[ngbml bg iZkZlbmb\ g^fZmh]^ li^\b^l Zg] Z[[k^obZm^] mkZgl\kbiml Zllh\bZm^] pbma k^lblmZg\^) KaZkfZ\h`^g^m B^ghfb\l -+' /,/( /-0) 4.) RbeebZflhg NH' Mh[^kmlhg aZko^m >G' I^o^n >' >Z[Zk^m E' >hkm^m E' K^bg^Zn I' <[hg`pZ H' >hnkmhm @' Mh[^kmlhg aMl) KGhN KZmah` ,+' ^,++.32+) 40) Nahhi RG' Hkhsbd C' Abla^k HC' ,440' Nmkn\mnk^ Zg] Z\mbobmr h_ Zo^kf^\mbgl Zg] fbe[^fr\bgl bg ZgbfZe a^Zema) Q^m KZkZlbmhe 04' ,.4(,01) 41) >Zfi[^ee R>' Abla^k HC' NmZie^r @J'

03 5KTKXGR 7TZXUJ[IZOUT

43) Mh]kb`n^s(K^k^s H<' PggZl\a OM' M^Ze(IZcZkkh J' -+,,' hneb[Zer N' >a^d^ M<' H^r^k MM' HZl E' H\>Zee KE' Khlm ME' Uhnk^ C' IhfZ H' TZf^h`h G' N^d^m^eb hgmkhe) <\mZ Okhi ,,,' -,,(-,3) ,++) =h\dZkb^ HE' ?^[ MH' -+,+' @ebfbgZmbhg h_ erfiaZmb\ _beZkbZlbl5 ]h p^ aZo^ ma^ ]kn`l mh \hfie^m^ ma^ ch[: >nkk Jibg Dg_^\m ?bl -.' 1,2(1-+) ,+,) ?^gm E<' Nfbma HH' QZllbeZmbl ?F' a^f -30' ,/34+(,/342) ,+.) GrgZ`a O' Grg\a ER' -+,+' < `er\bg^ k^lb]n^ ^ll^gmbZe _hk ab`a bo^kf^\mbg l^glbmbobmr bg >rl(ehhi bhg \aZgg^e k^\^imhkl) Dgm E KZkZlbmhe /+5 ,/22(,/3,) ,+/) Cb[[l M@' BhnZnq @' -+,,' Kkbg\bie^l h_ Z\mboZmbhg Zg] i^kf^Zmbhg bg Zg Zgbhg( l^e^\mbo^ >rl(ehhi k^\^imhk) IZmnk^ /2/' 0/(1+) ,+0) Rhelm^gahef^ nkk KaZkf =bhm^\aghe ,.' 32.(332) ,+2) NZg`lm^k I>' ?h[lhg ME' -++-' M> Kk^ll' =h\Z MZmhg) ,+3) Rhelm^gahef^ ' -++/' ?kn` k^lblmZg\^ bg o^m^kbgZkr a^efbgmal) Ok^g]l KZkZlbmhe -+' /14(/21) ,+4) FZieZg MH' -++/' ?kn` k^lblmZg\^ bg g^fZmh]^l h_ o^m^kbgZkr bfihkmZg\^5 Z lmZmnl k^ihkm) Ok^g]l KZkZlbmhe -+' /22(/3,) ,,+) Nnma^keZg] D<' G^Zmapb\d ?H' -+,,' hgpZr ?K' ,41/' QZkbZg\^ bg ma^ @__^\mbo^g^ll h_ OabZ[^g]Zshe^ Z`Zbglm 6GKSUTIN[Y IUTZUXZ[Y bg la^^i)

04 1NGVZKX &

,,.) N\hmm D' Khfkhr R@' F^grhg KM' Nfbma B' <]ebg`mhg =' Hhll <' -+,.' GZ\d h_ ^__b\Z\r h_ fhg^iZgm^e Z`Zbglm ?KRGJUXYGMOG IOXI[SIOTIZG Zg] ?XOINUYZXUTM_R[Y IUR[HXOLUXSOY ) Q^m KZkZlbmhe ,43' ,11(,2,) ,,/) Rbeelhg E' hhd <' >nmme^ HA' Fkb^d I' Chii^k I<' J">hgghk Q' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -++/' GZmkhmhqbg k^\^imhk lb`gZebg` ^g`Z`^l ma^ PI>(,.(]^i^g]^gm o^lb\e^(ikbfbg` iZmapZr bg 1# KRKMGTY ) >nkk =bhe ,/' ,.2/( ,.24) ,,0) ?^f^e^k E' Fk{`^k I' Fk{\d^g E' ohg ]^k C^r]^g Q>' MZf{gd^ N' Fnmme^k P' Hbeml\a N' Ghi^s >^i^]Z H' Fghq H' Q^k\knrll^ E' B^e]ah_ K' CZk]^k <' ohg NZflhg( Cbff^elmc^kgZ B' -+,.' Kareh`^g^mb\ \aZkZ\m^kbsZmbhg h_ [^mZ(mn[nebgl Zg] ]^o^ehif^gm h_ irkhl^jn^g\bg` ZllZrl _hk [^gsbfb]Zshe^ k^lblmZg\^ bg \Zmme^ g^fZmh]^l) KGhN Jg^ 3' ^2+-,-) ,,1) =hnk`nbgZm >' F^ee^k F' Kkb\aZk] MF' B^Zkr OB' -+,,' B^g^mb\ iherfhkiablf bg 2OXULORGXOG OSSOZOY ) Q^m KZkZlbmhe ,21' .13(.2.) ,,2) ?bZpZkZ <' ?kZd^ GE' Nnlpbeeh MM' FbaZkZ E' =ng]r ?<' N\hmm H@' CZei^ggr >' NmhmaZk] EM' Kkb\aZk] MF' -++4' ' Kbhg N?' FZf`gh E' BZk]hg E' Icbhdhn A' =hnllbg^lj H' Kkb\aZk] MF '-+,-' Nbg`e^ gn\e^hmb]^ iherfhkiablfl bg [^mZ(mn[nebg l^e^\m^] bg ;TINUIKXIG \UR\[R[Y _heehpbg` k^i^Zm^] bo^kf^\mbg mk^Zmf^gm5 ihllb[e^ bg]b\Zmbhg h_ k^lblmZg\^ l^e^\mbhg) Hhe =bh\a^f KZkZlbmhe ,30' ,+(,3) ,,4) =k^ggZg BK' AZbkp^Zma^k D' Okn]`^mm <' Ch^r @' H\>hr' H\>hgobee^ H' H^Zg^r H' Mh[bglhg H' H\A^kkZg I' MrZg G' GZgnll^ >' Hhmmb^k G' ' FZfbgldr M' -+,.' I^p Z]oZg\^f^gm bg Zgma^efbgmb\ ]kn`l bg o^m^kbgZkr f^]b\bg^) Ok^g]l KZkZlbmhe -4' ,-4(,./) ,--) FZfbgldr M' ?n\kZr K' Eng` H' >eho^k M' Mn_^g^k G' =hnob^k E' R^[^k NN' R^g`^k <' Rb^eZg](=^k`aZnl^g N' Bh^[^e O' BZnokr I' KZnmkZm A' Ndkbildr O' Akh^eb\a J' Fhfhbg(JdZ >' R^lmeng] =' Nen]^k <' HZl^k K' -++3' < g^p \eZll h_ Zgma^efbgmb\l ^__^\mbo^ Z`Zbglm ]kn`(k^lblmZgm g^fZmh]^l) IZmnk^ /0-' ,21(,3+)

1+ 5KTKXGR 7TZXUJ[IZOUT

,-.) Rheep^[^k C' Ib^f^kl @' Aen\d^ R' C' NnaZr]Z ?' ,44+' ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) ,-3) F^bl^k E' Nan(CnZ S' Pmsbg`^k E' -++1' @__^\m h_ mkb[^g]bfb]bg^ hg Z]nem 3INOTUYZUSG IGVXUTO aZk[hk^] bg fb\^' bg\en]bg` l\Zggbg` ^e^\mkhg fb\khl\hib\ h[l^koZmbhgl) E KZkZlbmhe 4-' 303(31-) ,-4) F^bl^k E' Nan(CnZ S' >ahee^m E' OZgg^k H' Pmsbg`^k E' -++2' @oZenZmbhg h_ ma^ OT \O\U Z\mbobmr h_ mkb[^g]bfb]bg^ Z`Zbglm >INOYZUYUSG SGTYUTO ' 4GYIOURG NKVGZOIG ' 1RUTUXINOY YOTKTYOY ' Zg] ;VOYZNUXINOY \O\KXXOTO ) a^fhma^k 0,' ,+41(,+43) ,.+) TnZg B' RZg` =' R^b >' UaZg` M' Bnh M' -++3' G>(HN ?^m^kfbgZmbhg h_ V(#,( ?bf^mareZfbgh ^marebfbgh$Zgbebg^5 Z H^mZ[hebm^ h_ Okb[^g]bfb]bg^ bg CnfZg KeZlfZ) >akhfZmh`kZiabZ 13' ,.4(,/-) ,.,) TnZg B' Sn E' Ln O' RZg` =' UaZg` M' R^b >' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l M ? ,+' 3.(4+) ,.-) Ohfebglhg B' <' Rhh]l M<' ,430' Oa^ ^__^\ml h_ Zfb]Zgm^e #=

1, 1NGVZKX &

,./) SbZh NC' Pmsbg`^k E' OZgg^k H' F^bl^k E' Sn^ E' -+,.' <]oZg\^l pbma ma^ >abg^l^ Zgma^efbgmab\ ]kn` mkb[^g]bfb]bg^ bg \ebgb\Ze mkbZel Zg] eZ[hkZmhkr bgo^lmb`Zmbhgl) <\mZ Okhi ,-1' ,,0(,-1) ,.0) SbZh NC' Rn US' UaZg` EC' RZg` NL' RZg` NC' Lbn ?>' RZg` >' -++2' >ebgb\Ze h[l^koZmbhg hg 344 \abe]k^g bg_^\m^] pbma bgm^lmbgZe g^fZmh]^l Zg] mk^Zm^] pbma mkb[^g]bfb]bg^ ^gm^kb\ \hZm^] mZ[e^ml) >abg E h_ KZkZlbmhe Zg] KZkZlbm ?bl -05 .2-(.20) ,.1) Nm^bgfZgg K' Uahn SI' ?n UR' EbZg` ET' SbZh NC' Rn US' Uahn C' Pmsbg`^k E' -++3' Okb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ _hk mk^Zmbg` lhbe(mkZglfbmm^] a^efbgmal' >ZXUTM_RUOJKY YZKXIUXGROY Zg] ?GKTOG lii)5 hi^g(eZ[^e kZg]hfbs^] mkbZe) KGhN I^`e Okhi ?bl -' ^.--) ,.2) Cn T' SbZh NC' hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' ' N\afb^]^k^k O' Uh\a^k M' N{llfnma M?' -++4' 7T \OZXU lrgma^lbl h_ g^p \r\eh]^ilbi^imb]^l h_ ma^ KA,+--(mri^5 ikh[bg` ma^ ZeiaZ(?(ar]khqr Z\b] mhe^kZg\^ h_ KA,+-- lrgma^mZl^) >a^f[bh\a^f ,+' .-.(.-3) ,/+) FZ\ab N' Dlaba <' O^kZ]Z H' ,440' @__^\ml h_ KA,+--< hg Z]nem /TMOUYZXUTM_R[Y IGTZUTKTYOY bg ma^ inefhgZkr Zkm^kb^l Zg] eZkoZ^ fb`kZmbg` bgmh ma^ \^gmkZe g^kohnl lrlm^f h_ kZml) KZkZlbmhe M^l 3,' 1.,(1.2) ,/,) RZg` H' RZmZgZ[^ I' NahfnkZ O' Jamhfh C' ,440' @__^\ml h_ KA,+--< hg :OVVUYZXUTM_R[Y HXGYOROKTYOY bg kZml Zg] 6_SKTURKVOY TGTG bg fb\^) Eig E KZkZlbmhe //+' .+1(.,+) ,/-) ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' N\agb^]^k O' FZe[^ E' H^g\d^ I' -+++' 7T \O\U Z\mbobmb^l h_ ma^ g^p Zgma^efbgmb\ ]^ilbi^imb]^ KA,+--<) KZkZlbmhe M^l 31' ,4/( ,44) ,/.) FZ\ab N' O^kZ]Z H' CZlabfhmh C' ,443' @__^\ml h_ Zfhkiahnl Zg] iherfhkial h_ KA,+--<' Z g^p Zgmbg^fZmh]^ ]kn`' hg /TMOYZXUTM_R[Y IUYZGXOIKTYOY bg fb\^) Eig E KaZkfZ\he 22' -.0(-/0) ,//) Iphln P' QZk`Zl H' CZk]^k <' F^bl^k E' -+,,' @__b\Z\r h_ ma^ \r\ehh\mZ]^ilbi^imb]^ KA,+--< Z`Zbglm 6KROMSUYUOJKY HGQKXO OT \OZXU Zg] OT \O\U ) KZkZlbmheh`r ,.3' ,,4.( ,-+,)

1- 5KTKXGR 7TZXUJ[IZOUT

,/0) RZg` H' RZmZgZ[^ I' NahfnkZ O' Jamhfh C' ,44/' @__^\ml h_ KA,+--< _khf 9_IKROG YZKXOROG hg ?XOINOTKRRG YVOXGROY ) Eig E KZkZlbmhe /.' ./1(.0+) ,/1) >hg]^k B<' Ehaglhg NN' IhpZdhpldb ?N' =eZd^ O@' ?nmmhg A@' I^elhg NE' OahfZl @H' ?Zobl EK' Oahfilhg ?K' ,440' ^lZk^ <' Ghak =' Dhkbh M' KZfinkbgb A' N\aZi^k M' =Zkmhebgb M' C^bg^ E' -++4' @__b\Z\r Zg] lZ_^mr h_ ^fh]^ilb]^ -), *ikZsbjnZgm^e 3)1 lihm(hg _hkfneZmbhg bg ma^ mk^Zmf^gm h_ _^ebg^ Z^enkhlmkhg`rehlbl) KZkZlbmhe M^l ,+0' 3.(34) ,0,) aZke^l N?' >knma^kl G' @i^ >' Thng` ?M' Fkb^`^k FE' -++0' @__b\Z\r h_ Z mhib\Zeer Z]fbgblm^k^] \hf[bgZmbhg h_ ^fh]^ilb]^ Zg] ikZsbjnZgm^e Z`Zbglm fZmnk^ Zg] bffZmnk^ /TI_RUYZUSG Z[HGKLUXSK bg ]hf^lmb\ \Zml) KZkZlbmhe M^l 42' 0,(02) ,0-) M^bg^f^r^k >M' >aZke^l N?' =n\a E' N^mmc^ O' knma^kl G' H\>Zee ER' Thng` ?M' @i^ >' -++0' @oZenZmbhg h_ ma^ ^__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mhib\Ze lhenmbhg Z`Zbglm Zl\Zkb] bg_^\mbhgl # ?U^UIGXG IGZO hk ?U^GYIGXOY RKUTOTG $ bg \Zml) KZkZlbmhe M^l 42' /,(0+) ,0.) N\abff^e <' aZke^l N' >knma^kl G' F^msbl E' Fhd ?E' FkZ^f^k A' H\>Zee ER' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ Z]nem /TI_RUYZUSG IGTOT[S Zg] @TIOTGXOG YZKTUIKVNGRG bg_^\mbhgl bg ]h`l) KZkZlbmhe M^l ,+0' 4(,1)

1. 1NGVZKX &

,0/) aZke^l N' Fhd ?E' FkZ^f^k A' Rhed^g N' Thng` ?' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ bg_^\mbhgl pbma ?U^UIGXG IGTOY Zg] ?U^GYIGXOY RKUTOTG bg ]h`l) KZkZlbmhe M^l ,+0' ,(3) ,00) K^mkr B' aZke^l N' >knma^kl G' Fhd ?E' FkZ^f^k A' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ Z]nem ?XOIN[XOY \[RVOY bg_^\mbhgl bg ]h`l) KZkZlbmhe M^l ,+0' ,2(--) ,02) UZag^k C' OZn[^km <' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++,' @__^\ml h_ =Zr //(//++' Z g^p \r\eh]^ilbi^imb]^' hg ]^o^ehibg` lmZ`^l h_ _beZkbZ^ #/IGTZNUINKRUTKSG \OZKGK! 0X[MOG SGRG_O ' 8OZUSUYUOJKY YOMSUJUTZOY $ bg ma^ kh]^gm 9GYZUS_Y IU[ING ) <\mZ Okhi 3+' ,4(-3) ,03) UZag^k C' OZn[^km <' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++,' AbeZkb\b]Ze ^__b\Z\r h_ ma^ Zgma^efbgmb\Zeer Z\mbo^ \r\eh]^ilbi^imb]^l) Dgm E KZkZlbmhe .,' ,0,0( ,0--) ,04) Ohpglhg N' Ak^^fZg <' CZkkbl <' CZk]^k <' -++0' <\bmbomr h_ ma^ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^ Z`Zbglm ;TINUIKXIG M[ZZ[XUYG ' ;TINUIKXIG ROKTGROY Zg] 0X[MOG VGNGTMO ) eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) ,1,) B^Zkr OB' Rhh F' H\>Zkmar EN' HZ\d^gsb^ >?' Chkmhg E' Kkb\aZk] MF' ]^ NbeoZ IM' JeebZkh KG' GZs]bgl(C^e]l EF' @g`^el ?<' =ng]r ?<' -+,+' Pgk^lheo^] blln^l bg Zgma^efbgmb\ iaZkfZ\heh`r _hk a^efbgmabZl^l h_ anfZgl) Dgm E KZkZlbmhe /+' ,(,.) ,1-) ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' NZg`lm^k I>' >he^l B>' -++0' @__b\Z\r h_ mph \r\ehh\mZ]^ilbi^imb]^l' KA,+--< Zg] ^fh]^ilb]^' Z`Zbglm Zgma^efbgmb\(k^lblmZgm g^fZmh]^l bg la^^i Zg] \Zmme^) KZkZlbmheh`r ,.+' ./.(./2) ,1.) Ke^bll P' CZk]^k <' Onk[^k` <' Ghg]^klaZnl^g H' DbgnfZ F' H^g\d^ I' E^l\ad^ K' =hgl^ B' ,441' Nrgma^lbl h_ Z kZ]bheZ[^e^] \r\eh]^ilbi^imb]^ V.C(f^mareW KA,+--<) E GZ[^ee^] >hfi MZ]bhiaZkf .3' 1,(14)

1/ 5KTKXGR 7TZXUJ[IZOUT

,1/) >a^g R' O^kZ]Z H' >a^g` EO' ,441' >aZkZ\m^kbsZmbhg h_ ln[mri^l h_ `ZffZ( Zfbgh[nmrkb\ Z\b] k^\^imhkl bg Zg /YIGXOY S[YIRK ik^iZkZmbhg [r [bg]bg` ZllZr Zg] [bg]bg` h_ KA,+--<' Z g^p Zgma^efbgmb\' hg ma^ k^\^imhkl) KZkZlbmhe M^l 3-' 42(,+,) ,10) Che]^g(?r^ G' C^pbmm BH' RZgg FO' Fkh`l`ZZk](GZkl^g K' RZed^k ME' ,433' Nmn]b^l bgoheobg` Zo^kf^\mbg Zg] ma^ /(Zfbgh[nmrkb\ Z\b] #B<=<$ k^\^imhk h_ /YIGXOY Y[[S fnl\e^) K^lm HZgZ` N\b -/' -.,(-/0) ,11) Hbeml\a NH' Fk{\d^g E' ?^f^e^k E' EZgll^g DE' Fk{`^k I' CZk]^k <' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' ?^\k^Zl^] ^fh]^ilb]^ l^glbmbobmr bg ng\(/4 `ZffZ( Zfbgh[nmrkb\ Z\b] #B<=<$(k^\^imhk(]^_b\b^gm 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe /-' 21,(22+) ,12) NZ^`^k =' N\afbmm(Rk^]^ CK' ?^agaZk]m H' =^gm^g RK' Fk{\d^g E' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' Rb^`Zg] C' Rng]^keb\a A' -++,' GZmkhiabebg(ebd^ k^\^imhk _khf ma^ iZkZlbmb\ g^fZmh]^ 6GKSUTIN[Y IUTZUXZ[Y Zl mZk`^m _hk ma^ Zgma^efbgmb\ ]^ilbi^imb]^ KA,+--<) A' CZk]^k <' N\agb^]^k O' Ch`eng] E' ohg NZflhg(Cbff^elmc^kgZ B' -++0' KnmZmbo^ B ikhm^bg(\hnie^] k^\^imhkl bg iZkZlbmb\ g^fZmh]^l ( ihm^gmbZe mZk`^ml _hk ma^ g^p Zgma^efbgmb\ \eZll \r\ehh\mZ]^ilbi^imb]^l: KZkZlbmhe M^l 42' --(.-) ,2+) =nee F' >hhd <' Chii^k I<' CZk]^k <' Che]^g(?r^ G' RZed^k ME' -++2' @__^\ml h_ ma^ gho^e Zgma^efbgmb\ ^fh]^ilb]^ hg ma^ eh\hfhmbhg' ^``(eZrbg` [^aZobhnk Zg] ]^o^ehif^gm h_ 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' 1-2(1.1) ,2,) Che]^g(?r^ G' J">hgghk Q' Chii^k I<' RZed^k ME' CZk]^k <' =nee F' Bn^lm H' -++2' NGJ' NGJ' jnb\d' jnb\d' lehp5 \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^el Zl k^`neZmhkl h_ 1GKTUXNGHJOZOY KRKMGTY [^aZobhnk Zg] mZk`^ml _hk Zgma^efbgmb\l) Dgo^km I^nkhl\b 2' ,44(-+3) ,2-) R^es >' Fk{`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fk{\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+)

10 1NGVZKX &

,2.) >kbl_hk] <' HnkkZr >' J">hgghk Q' @]pZk]l ME' Fk{`^k I' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -+,,' N^e^\mbo^ mhqb\bmr h_ ma^ Zgma^efbgmb\ ^fh]^ilb]^ k^o^Ze^] [r a^m^kheh`hnl ^qik^llbhg h_ anfZg F>IH<, bg 1GKTUXNGHJOZOY KRKMGTY ) Hhe KaZkfZ\he 24' ,+.,(,+/.) ,2/) =nqmhg NF' I^o^n >' >aZko^m >G' Mh[^kmlhg C' Hb\aZ^e =A' ,44-' <\nm^ mhqb\bmr h_ iZkZa^kjnZfb]^ Zg] bml ihm^gmbZe Zl Zg Zgma^efbgmb\) ehmab^k HA' Ehaglhg NN' -++,' N^fb(lrgma^lbl h_ -(]^hqh( Zg] .(^ib( iZkZa^kjnZfb]^ <) =bhhk` H^] >a^f G^mm ,,' 00.(00/) ,22) Gbmme^ KM' Ch]`^l <' RZmlhg OB' N^^] E<' HZ^]^k NE' -+,+' Ab^e] ^__b\Z\r Zg] lZ_^mr h_ Zg hkZe _hkfneZmbhg h_ ma^ gho^e \hf[bgZmbhg Zgma^efbgmb\' ]^kjnZgm^e(Z[Zf^\mbg' bg la^^i bg I^p U^ZeZg]) I U Q^m E 03' ,-,(,-4) ,23) LbZg C' HZkmbg ME' Mh[^kmlhg aM k^lheo^] Zm ma^ lbg`e^(\aZgg^e e^o^e bg /YIGXOY Y[[S ) Aebg Dg_^\m ?bl /+' ,,2.(,,3+) ,3-) Mhllb`ghe EA'

11 5KTKXGR 7TZXUJ[IZOUT

,30) Ak^b @' @]^k EK' -++.' >hf[bgZmbhg \a^fhma^kZir' Dg5 Fn_^ ?R' Kheeh\d M@' R^b\a^e[Znf MM' =Zlm M>' N) BO' CheeZg] EA' Ak^b @ #@]l)$ >Zg\^k H^]b\bg^ 1) ?^\d^k Kn[eblabg`' I^p Thkd) ,31) Bneb\d MH' H^eehkl ER' CZoebk ?' @khg EE' BhgsZe^s >' H\HZahg ?' Mb\afZg ??' QZe^gmbg^ AO' EhgZl G' H^b[haf <' @fbgb @<' >ah]Zd^pbms E<' ,442' Ok^Zmf^gm pbma bg]bgZobk' sb]hon]bg^' Zg] eZfbon]bg^ bg Z]neml pbma anfZg bffngh]^_b\b^g\r obknl bg_^\mbhg Zg] ikbhk Zgmbk^mkhobkZe ma^kZir) I @g`e E H^] ..2' 2./(2.4) ,32) G^Zmapb\d ?H' Chldbg` =>' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 fh]^eebg` lmkZm^`b\ nl^ h_ Z g^p Zgma^efbgmb\ \eZll mh lehp ma^ ]^o^ehif^gm h_ k^lblmZg\^ mh ^qblmbg` \eZll^l) I U Q^m E 02' -+.(-+2) ,33) G^Zmapb\d ?H' Chldbg` =>' =bll^m N<' H\FZr >C' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 bl bm _^Zlb[e^ bg I^p U^ZeZg] mh ]^eZr ma^ ^f^k`^g\^ h_ k^lblmZg\^ mh Z g^p Zgma^efbgmb\ \eZll: I U Q^m E 02' ,3,(,4-) ,34) B^Zkr OB' Chldbg` =>' Ndn\^ KE' ohg NZflhg(Cbff^elmc^kgZ B' HZ^]^k N' Che]lphkma K' Khfkhr R' Q^k\knrll^ E' -+,-' Rhke] ' Ib\aheZl ?M' >hq BB' >hg]^k B<' -+,,' @__b\Z\r h_ Z \hf[bg^] hkZe _hkfneZmbhg h_ ]^kjnZgm^e(Z[Zf^\mbg Z`Zbglm ma^ Z]nem Zg] eZkoZe lmZ`^l h_ g^fZmh]^l bg la^^i' bg\en]bg` Zgma^efbgmb\(k^lblmZgm lmkZbgl) Q^m KZkZlbmhe ,3,' ,3+(,4.) ,4,) =Zssh\\ab >' HhkmZkbgh H' BkZg]b B' FkZf^k GC' B^g\ab >' =Zg]b >' B^g\ab H' NZ\\ab G' H\>Zee ER' -++3' >hf[bg^] bo^kf^\mbg Zg] ]hqr\r\ebg^ mk^Zmf^gm aZl fb\kh_beZkb\b]Ze Zg] Z]nemb\b]Ze Z\mbobmr Z`Zbglm 2OXULORGXOG OSSOZOY bg ^qi^kbf^gmZeer bg_^\m^] ]h`l) Dgm E KZkZlbmhe .3' ,/+,(,/,+) ,4-) BkZg]b B' LnbgmZoZeeZ >' HZokhihnehn <' B^g\ab H' Bgn]b B' =^kmhgb B' FkZf^k G' -+,+' < \hf[bgZmbhg h_ ]hqr\r\ebg^ Zg] bo^kf^\mbg bl Z]nemb\b]Ze bg ]h`l pbma gZmnkZeer Z\jnbk^] a^Zkmphkf ]bl^Zl^ # 2OXULORGXOG OSSOZOY $) Q^m KZkZlbmhe ,14' ./2( .0,) ,4.) =Zkg^l @C' ?h[lhg ME' =Zk`^k D<' ,440' Rhkf \hgmkhe Zg] Zgma^efbgmb\ k^lblmZg\^5 Z]o^gmnk^l pbma Z fh]^e) KZkZlbmhe Oh]Zr ,,' 01(1.)

12 1NGVZKX &

,4/) =^Z\a HE' Nmk^bm OB' <]]bll ?B' Kkhli^k^ M' Mh[^kml EH' GZffb^ KE' ,444' ebg Dg_^\m ?bl 0,' ,/-+(,/-3) ,41) Ni^b\a ='

13 Chapter 2

In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial

Kulke D., Krücken J., Welz C., von Samson-Himmelstjerna G., Harder A.

Acta Tropica 2012, 123 (2): 78-84.

http://dx.doi.org/10.1016/j.actatropica.2012.03.008 1NGVZKX '

* "2 9/93 STTWQOQg ]T bVS O\bVSZ[W\bWQ b`WPS\RW[WRW\S OUOW\ab bVS QSab]RS !:1,230,4/6 1/+536731) W\ O Q]\b`]ZZSR ZOP]`Ob]`g b`WOZ

*&) 4Pab`OQb

Okb[^g]bfb]bg^ aZl [^^g k^`blm^k^] _hk ma^ mk^Zmf^gm h_ anfZg lhbe mkZglfbmm^] a^efbgmabZl^l bg >abgZ) Dg ma^ fh]^e g^fZmh]^ 1# KRKMGTY bm bl Zg Z`hgblm h_ G(ln[mri^ gb\hmbgb\ Z\^mre\ahebg^ k^\^imhkl Zg] ma^k^_hk^ laZk^l bml fh]^ h_ Z\mbhg pbma e^oZfblhe^ Zg] irkZgm^e) =^lb]^l bml [khZ] li^\mknf h_ g^fZmb\b]Ze ^__b\Z\r' mkb[^g]bfb]bg^ bl ^__b\Z\bhnl Z`Zbglm l^o^kZe mk^fZmh]^l Zg] aZl [^^g Zmmkb[nm^] mh aZo^ Zgmb(\^lmh]Ze ^__^\ml) Chp^o^k' ma^k^ Zk^ _^p in[ebla^] ]ZmZ ZoZbeZ[e^ _hk ma^ eZmm^k) Oa^ ^__b\Z\r h_ mkb[^g]bfb]bg^ Zg] bml g^fZmb\b]Ze f^mZ[hebm^ ]hf[bgZmbhgl h_ e^oZfblhe^ pbma mkb[^g]bfb]bg^ ]b] ghm Zn`f^gm ma^ ^__^\ml h_ mkb[^g]bfb]bg^ Zehg^ Zg] Zl ^qi^\m^] e^oZfblhe^ Zehg^ Zelh lahp^] gh Zgmb(\^lmh]Ze Z\mbobmr) Oh hnk dghpe^]`^' mabl lmn]r lahpl _hk ma^ _bklm mbf^ Z\mbobmr h_ mkb[^g]bfb]bg^ Z`Zbglm Z \^lmh]^ bg Z \hgmkhee^] eZ[hkZmhkr lmn]r) ?n^ mh ma^ ^q\^ee^gm \nk^ kZm^l h[l^ko^] a^k^' fnembie^ mkb[^g]bfb]bg^ mk^Zmf^gml fb`am [^ \hglb]^k^] Zl nl^_ne l\a^f^ _hk mk^Zmf^gml h_ \^lmh]^' g^fZmh]^ Zg] mk^fZmh]^ bg_^\mbhgl Zemahn`a mabl phne] lb`gb_b\Zgmer bg\k^Zl^ [hma \hlml Zg] fZgZ`^f^gm ^__hkml) Hhk^ho^k' ma^ ]b__^k^g\^l [^mp^^g mkb[^g]bfb]bg^ Zg] ]

2+ 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

*&* <\b`]RcQbW]\

KZkZlbmb\ a^efbgmal \Znl^ Z an`^ [nm _k^jn^gmer ng]^k^lmbfZm^] ?

9WU& *%)& Nmkn\mnk^ _hkfneZ h_ <$ Zfb]Zgm^e' =$ mkb[^g]bfb]bg^ >$ Zg] ]

# XGZZO V,2W) Chp^o^k' fnembie^ #ni mh _hnk$ mk^Zmf^gml pbma ab`a ]hlZ`^l #ni mh 0++ f`*d` [h]r p^b`am$ p^k^ g^\^llZkr mh Z\ab^o^ Z \hfie^m^ ^ebfbgZmbhg h_ ma^ phkf [nk]^gl V,2W) Dg Z]]bmbhg' ma^ lZf^ Znmahkl Zek^Z]r k^ihkm^] Zm e^Zlm Z [Zl^ebg^ Z\mbobmr Z`Zbglm lhf^ ieZmra^efbgmal) Oa^l^ ^Zker k^lneml ikhfbl^] Z [khZ](li^\mknf Zgma^efbgmb\ Z\mbobmr h_ mabl ]kn` \eZll) < lrff^mkb\Ze ]bZfb]bg^ ]^kboZmbo^ h_ Zfb]Zgm^e' mkb[^g]bfb]bg^ #Ab`) -(,=$' pZl m^lm^] [r ma^ >abg^l^ IZmbhgZe Dglmbmnm^ h_ KZkZlbmb\ ?bl^Zl^l ]nkbg` ma^ fb] ,43+l) Pl^] Zm \hfiZkZmbo^er ehp ]hlZ`^l' mkb[^g]bfb]bg^ lahp^] ab`a ^__b\Z\r Z`Zbglm Z [khZ] kZg`^ h_ g^fZmh]^l bg kh]^gml #0+(-++ f`*d` [h]r p^b`am$' ]h`l #1(-0 f`*d` [h]r p^b`am$ Zg] anfZgl #-++ f` _hk \abe]k^g hk /++ f` mZ[e^ml _hk Z]neml$ V-1W) Chp^o^k' [hma Zfb]Zgm^e Zg] mkb[^g]bfb]bg^ Zk^ kZib]er f^mZ[hebl^] mh ]$ V,3' ,4W' pab\a [r bml^e_ ^q^kml Z lmkhg` g^fZmb\b]Ze Z\mbobmr Z`Zbglm [hma ma^ fh]^e hk`Zgblf 1# KRKMGTY Zg] iZkZlbmb\ g^fZmh]^l V-+' -,W) <_m^k l^o^kZe r^Zkl h_ _nkma^k ^qi^kbf^gmZe k^l^Zk\a Zg] \ebgb\Ze bgo^lmb`Zmbhgl' mkb[^g]bfb]bg^ aZl [^^g k^`blm^k^] _hk ma^ mk^Zmf^gm h_ anfZg lhbe mkZglfbmm^] a^efbgmabZl^l \Znl^] [r /# R[SHXOIUOJKY ' /# J[UJKTGRK ' :# GSKXOIGT[Y ' Zg] 3# \KXSOI[RGXOY bg ma^ K^hie^âl M^in[eb\ h_ >abgZ bg -++/ V,1W) Ahk anfZgl' ma^ nl^ h_ ma^ hkZe mZ[e^m bl \hglb]^k^] mh [^ lZ_^ Zg] hger o^kr eb`am Zg] mkZglb^gm Z]o^kl^ ^__^\ml b_ Zgr aZo^ [^^g k^ihkm^] V--W) Nmn]b^l hg mhqb\bmr aZo^ [^^g lnffZkbl^] [r SbZh KZ GR# V,1W) Dg [kb^_' Z\nm^ mhqb\bmr Z_m^k hkkZe hk bgmkZi^kbmhg^Ze Z]fbgblmkZmbhg mh fb\^ pZl ]^m^kfbg^] pbma Zg G? 0+ h_ 40+ É -+2 f`*d` [p

Zg] -22 É -2 f`*d` [p' k^li^\mbo^er) Dg kZml' ma^ hkZe G? 0+ pZl ^o^g -++, É 24 f`*d` [p)

2- 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

Hhk^ho^k' kZml aZ] gh ]^m^\mZ[e^ lb]^ ^__^\ml ni mh -0+ f`*d` `bo^g hkZeer hg ,/ \hgl^\nmbo^ ]Zrl bg]b\Zmbg` Z[l^g\^ h_ ehg`(m^kf mhqb\bmr) aM' Zl k^o^Ze^] [r bgo^lmb`Zmbhgl nlbg` ehll(h_(_ng\mbhg fnmZgml bg 1# KRKMGTY ) Oabl ln``^lml maZm ma^ fh]^ h_ Z\mbhg Z`Zbglm g^fZmh]^l bl o^kr lbfbeZk mh ma^ hg^ h_ e^oZfblhe^ Zg] irkZgm^e V-.W) Chp^o^k' lrg^k`blmb\ ^__^\ml h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ aZo^ k^\^gmer [^^g k^ihkm^] Z`Zbglm /# IK_RGTOI[S OT \OZXU Zg] OT \O\U V-,W Zg] p^k^ Zelh ]^m^\m^] [r ma^ Znmahkl bg Z :# HXGYOROKTYOY kZm fh]^e #ngin[ebla^] ]ZmZ$) Nrg^k`blmb\ Z\mbobmr ln``^lml maZm ma^ fh]^l h_ Z\mbhg Zk^ Zm e^Zlm ghm \hfie^m^er b]^gmb\Ze) Jma^kpbl^' hger Z]]bmbo^ ^__^\ml phne] [^ ^qi^\m^]) Dg Z]]bmbhg mh bml `hh] ^__b\Z\r Z`Zbglm `Zlmkhbgm^lmbgZe g^fZmh]^l' mkb[^g]bfb]bg^ aZl [^^g ]^l\kb[^] mh [^ ^__b\Z\bhnl Z`Zbglm Zm e^Zlm lhf^ mk^fZmh]^l # O#K# 3# IGVXUTO ' 1# YOTKTYOY ' ;# \O\KXXOTO $ pa^k^Zl gh ^__^\ml hg bg_^\mbhgl pbma 4# NKVGZOIG Zg] ># SGTYUTO p^k^ _hng] V,1' -/' -0W) Oahn`a ma^k^ p^k^ ^Zker k^ihkml hg fh]^kZm^ Z\mbobmr h_ Zfb]Zgm^e Z`Zbglm ma^ \^lmh]^ 6# JOSOT[ZG [nm ghm Z`Zbglm 6# TGTG V,2W' ma^l^ k^ihkml p^k^ lhf^paZm bg_hkfZe pbmahnm Zgr ]^mZbe^] bg_hkfZmbhg hg ikh\^]nk^l Zg] ]ZmZ ^q\^im _hk Zg @? 44 oZen^) @__b\Z\r h_ mkb[^g]bfb]bg^ Z`Zbglm nglmZm^] \^lmh]^l bg \ab\d^g bl Zelh hger \bk\nflmZgmbZeer f^gmbhg^] bg Z k^ob^p [nm ]^mZbe^] ]ZmZ Zk^ ghm ZoZbeZ[e^ V,1W) Hhk^ho^k' lhf^ Z\mbobmr h_ mkb[^g]bfb]bg^ Z`Zbglm anfZg bgm^lmbgZe mZ^gbZlbl aZl [^^g _hng] bg Zg hi^g(eZ[^ee^] kZg]hfbl^] \ebgb\Ze mkbZe V-1W) Oh _nkma^k \hkkh[hkZm^ ma^ ihm^gmbZe h_ mkb[^g]bfb]bg^ Zl Z [khZ](li^\mknf Zgma^efbgmb\ bg fnemb(]hl^ mk^Zmf^gm l\a^]ne^l' ma^ ik^l^gm lmn]r Zbf^] mh ^oZenZm^ ma^ ^__b\Z\r h_ mkb[^g]bfb]bg^ Z`Zbglm ma^ fhnl^ [be^ ]n\m mZi^phkf 6# SOIXUYZUSG ' Z p^ee(^lmZ[ebla^] kh]^gm fh]^e) <]nem lmZ`^l h_ 6# SOIXUYZUSG Zk^ eh\Zm^] bg ma^ 2[IZ[Y INURKJUIN[Y #\hffhg [be^ ]n\m$ h_ fb\^ V-2W) =^lb]^l ma^ ^oZenZmbhg h_ ma^ Zgmb(\^lmh]Ze ^__b\Z\r h_ mkb[^g]bfb]bg^ Z`Zbglm ma^ Z]nem fhnl^ [be^ ]n\m mZi^phkf' ma^ lmn]r bgm^g]^] mh \hfiZk^ mkb[^g]bfb]bg^ pbma bml g^fZmb\b]Ze f^mZ[hebm^ ]

2. 1NGVZKX '

GOP& *%)& Kn[ebla^] mkb[^g]bfb]bg^ ]hlZ`^l Zg] \nk^ kZm^l

CO`OaWbS ;]ab G57 R]aOUS O 6c`S `ObS ESTS`S\QS AS[Ob]RSa2 ZXUTM_RUOJKY XGZZO MZml ,! 0+ f` ,++)+ V/0W >ZXUTM_RUOJKY YZKXIUXGROY CnfZgl ,! /++ f` ,+)0 V-1W Jqrnkb]l5 3TZKXUHO[Y \KXSOI[RGXOY CnfZgl ,! -++ f` 2/), V/.W >_VNGIOG SKYUIXOIKZO Hhnl^ ,! -++ f`*d` [p 4/)0 V,1W Okb\ah\^iaZeb]l5 ?XOINOTKRRG YVOXGROY [ Hb\^ 1! .++ f`*d` [p 43)1 V//W ?XOIN[XOY ZXOINO[XG CnfZgl .! /++ f` ..'. V/.W ?XOIN[XOY ZXOINO[XG CnfZgl ,! /++ f` 21)3 V/-W G`S[Ob]RSa2 1RUTUXINOY YOTKTYOY MZml ,! ,0+ f`*d` [p 44), V-0W 4GYIOURG NKVGZOIG MZml ,! 3++ f`*d` [p +)+ V-0W 3INOTUYZUSG IGVXUTO Hb\^ ,! ,-0 f`*d` [p ,++)+ V-/W ;VOYZNUXINOY \O\KXXOTO CZflm^k ,! /++ f`*d` [p 40)2 V-0W INOYZUYUSG SGTYUTO Hb\^ ,! /++ f`*d` [p +)+ V-0W 6Sab]RSa2 6_SKTURKVOY SOIXUYZUSG Hb\^ .! 0+ f`*d` [p 42)3 ?GKTOG lii) CnfZgl ,! /++ f` 11)2 V-1W

D_ ghm hma^kpbl^ bg]b\Zm^]' mk^Zmf^gml p^k^ ZepZrl Z`Zbglm fZmnk^ lmZ`^l Zg] hkZe khnm^ h_ Z]fbgblmkZmbhg pZl nl^]) Z?hlZ`^l Zk^ ^bma^k `bo^g Zl f`*d` [h]r p^b`am #[p$ hk Zl mhmZe Zfhngm h_ mkb[^g]bfb]bg^ #O=?$ i^k bg]bob]nZe bg f`) [@g\ZilneZm^] eZkoZ^

2/ 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

*&+ @ObS`WOZa O\R [SbV]Ra

2X[MY G^oZfblhe^ pZl ink\aZl^] _khf Nb`fZ(hfiZgr Gbfbm^] #Ub[h' K^hie^"l M^in[eb\ h_ >abgZ$ Zg] =Zr^k k^fhiahk @G #=k^fhiahk @G*pZm^k i^k ,++ ` [h]r p^b`am)

/TOSGR K^VKXOSKTZY Zk^ hglnf^k Kkhm^\mbhg' Ihkma Mabg^( R^lmiaZebZ' B^kfZgr #GZg]^lZfm _{k IZmnk(' Pfp^em( ng] Q^k[kZn\a^kl\anms Ihk]ka^bg( R^lm_Ze^g6 Grlmb\^k\hb]l p^k^ f^\aZgb\Zeer blheZm^] Zg] ]kZpg ni bgmh ma^ `ZoZ`^) 20 1NGVZKX '

Ok^Zmf^gm(]hlZ`^l p^k^ \Ze\neZm^] _hk ^Z\a ZgbfZe ]^i^g]bg` hg bg]bob]nZe [h]r p^b`aml ]^m^kfbg^] hg ]Zr .. V#O# Jg ]Zrl ./(.1 V#O# fb\^ p^k^ hkZeer mk^Zm^] pbma >k^fhiahk @G*pZm^k ]bli^klbhgl mh Z\ab^o^ ]hlZ`^l h_ ,+ f`*d`' -0 f`*d`' 0+ f`*d`' hk ,++ f`*d` mkb[^g]bfb]bg^' 0+ f`*d` hk ,++ f`*d` ]N DI>C@H

]ZmZ[Zl^ h_ ma^ RCJ f^gmbhgl Z G? 0+ h_ -+0(-30 f`*d` _hk Z\nm^ mhqb\bmr h_ e^oZfblhe^ bg fb\^ pa^k^Zl ,++ f`*d` ]b] ghm k^lnem bg Zgr lb`gl h_ mhqb\bmr) Oa^ g^`Zmbo^(\hgmkhe `khnil k^\^bo^] >k^fhiahk @G*pZm^k hger) Dg Z]]bmbhg' mph \hf[bgZmbhgl p^k^ Z]fbgblm^k^] k^lnembg` ^bma^k bg ,+ f`*d` mkb[^g]bfb]bg^ ienl ,++ f`*d` e^oZfblhe^ hk bg -0 f`*d` mkb[^g]bfb]bg^ ienl ,++ f`*d` e^oZfblhe^) Jg ]Zr .2 V#O#' fb\^ p^k^ ^nmaZgbl^] [r \Zk[hg ]bhqb]^ ln__h\Zmbhg) Nn[l^jn^gmer' g^\khilr pZl i^k_hkf^] Zg] ma^ phkf [nk]^gl bg ma^ \hffhg [be^ ]n\ml Zg] ma^ ]nh]^gnf p^k^ ]^m^kfbg^])

3LLOIGI_ JKZKXSOTGZOUT GTJ YZGZOYZOIGR GTGR_YOY Inf[^kl h_ phkfl _hng] bg mk^Zmf^gm `khnil p^k^ \hfiZk^] mh ma^ \hgmkhel nlbg` ma^ ghg( iZkZf^mkb\ FknldZe(RZeebl m^lm pbma ?nggâl ihlm ah\ m^lm _hk b]^gmb_b\Zmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g bg]bob]nZe `khnil) Ih lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g \hgmkhel p^k^ h[l^ko^] pa^g ma^ _bo^ ^qi^kbf^gmZe [eh\dl p^k^ \hfiZk^]) Oa^k^_hk^' phkf \hngml _khf ]b__^k^gm ^qi^kbf^gml p^k^ ihhe^] Zg] mk^Zm^] Zl Z lbg`e^ [eh\d ]^lb`g ^qi^kbf^gm) >Ze\neZmbhgl p^k^ i^k_hkf^] nlbg` BkZiaKZ] Kkblf lh_mpZk^ o^klbhg 0)+.)

21 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

*&, ESacZba

3LLKIZY UL TKSGZUJK GIKZ_RINUROTK XKIKVZUX GMUTOYZY UT 6# SOIXUYZUSG ]UXS H[XJKT Ahk Zee mk^Zmf^gm `khnil Zg] g^`Zmbo^(\hgmkhe `khnil h_ _bo^ \hgl^\nmbo^ [eh\dl phkf \hngml' f^Zg phkf [nk]^gl Zg] lmZg]Zk] ]^obZmbhgl Zk^ lnffZkbl^] bg OZ[) -( -) Dg Z]]bmbhg' _hk Zee mk^Zmf^gm `khnil i^k\^gmZ`^l h_ ^__b\Z\r Z`Zbglm 6# SOIXUYZUSG pbma k^_^k^g\^ mh ma^ k^li^\mbo^ \hgmkhe(`khni Zk^ `bo^g #OZ[) -( -$) Dg ma^ _heehpbg`' Zee `khnil pab\a p^k^ mk^Zm^] pbma ma^ lZf^ ]kn` ]hlZ`^l p^k^ mhmZee^] ni _hk _nkma^k ZgZerlbl k^lnembg` bg m^g fb\^ _hk ,+ f`*d`' m^g fb\^ _hk -0 f`*d`' m^g fb\^ _hk 0+ f`*d`' _bo^ fb\^ _hk ,++ f`*d` mkb[^g]bfb]bg^' _bo^ fb\^ _hk 0+ f`*d`' _bo^ fb\^ _hk ,++ f`*d` ]

22 1NGVZKX '

GOP& *%*& ?^lb`g Zg] hnm\hf^ h_ bg]bob]nZe ZgbfZe ^qi^kbf^gml

J]`[a'[]caS @SO\ É F7 % `SRcQbW]\ )ab 5Z]QY2 >hgmkhe -6 /6 /6 06 16 /)- É ,)0 0+ f`*d` ]^Z\reZm^] Zfb]Zgm^e -6 06 06 16 26 0)+ É ,)4 +)+ 0+ f`*d` mkb[^g]bfb]bg^ +6 +6 +6 +6 ,6 +)- É +)0 40)- É ,,)4 0+ f`*d` e^oZfblhe^ .6 /6 /6 06 06 /)- É +)3 +)+ *\R 5Z]QY2 >hgmkhe ,6 ,6 /6 06 26 .)1 É -)1 0+ f`*d` mkb[^g]bfb]bg^ +6 +6 +6 +6 +6 +)+ ,++)+ ,++ f`*d` mkb[^g]bfb]bg^ +6 +6 +6 +6 +6 +)+ ,++)+ +`R 5Z]QY2 >hgmkhe .6 /6 /6 26 26 0)+ É ,)4 ,++ f`*d` e^oZfblhe^ ,6 /6 06 16 16 /)/ É -), ,-)+ É /-)+ ,+ f`*d` mkb[^g]bfb]bg^ ,6 -6 06 06 26 /)+ É -)0 -+)+ É 0+)+ -0 f`*d` mkb[^g]bfb]bg^ +6 +6 +6 -6 36 -)+ É .)0 1+)+ É 2+)+ ,bV 5Z]QY2 >hgmkhe ,6 ,6 -6 06 26 .)- É -)2 ,++ f`*d` ]^Z\reZm^] Zfb]Zgm^e .6 06 06 16 36 0)/ É ,)3 +)+ ,+ f`*d` mkb[^g]bfb]bg^ -6 /6 16 26 26 0)- É -)- +)+ ,++ f`*d` e^oZfblhe^ -6 /6 /6 06 06 /)+ É ,)- +)+ ,++ f`*d` e^oZfblhe^ & ,+ f`*d` mkb[^g]bfb]bg^ ,6 -6 -6 .6 26 .)+ É -)/ 1). É 20)+ -bV 5Z]QY2 >hgmkhe /6 16 26 26 36 1)/ É ,)0 -0 f`*d` mkb[^g]bfb]bg^ +6 ,6 ,6 .6 /6 ,)3 É ,)1 2,)4 É -0)+ ,++ f`*d` e^oZfblhe^ ,6 .6 06 16 36 /)1 É -)2 -3), É /-)- ,++ f`*d` e^oZfblhe^ & -0 f`*d` mkb[^g]bfb]bg^ +6 +6 +6 06 16 -)- É .)+ 10)1 É /1)4 Inf[^kl bg ma^ \henfg phkfl*fhnl^ k^ik^l^gm iZkZlbm^ gnf[^kl k^\ho^k^] _khf bg]bob]nZe ZgbfZel)

3LLKIZY UL JX[M IUSHOTGZOUT Okb[^g]bfb]bg^ Zg] e^oZfblhe^ p^k^ \hf[bg^] Zm ln[himbfZe ]hlZ`^l h_ mkb[^g]bfb]bg^ mh b]^gmb_r Zgr ihm^gmbZe bgm^kZ\mbhg) <`Zbg' ,+ f`*d` mkb[^g]bfb]bg^ ]b] ghm lahp Zgr ^__^\ml Z`Zbglm 6# SOIXUYZUSG pabe^ -0 f`*d` k^]n\^] ma^ phkf [nk]^g [r Z[hnm 2,)4 É -0)+ mahn`a ma^ ^__^\m pZl Z`Zbg ghm lmZmblmb\Zeer lb`gb_b\Zgm #OZ[) -( - Zg] Ab`) -( -=$) >hf[bgZmbhgl h_ ,+ f`*d` hk -0 f`*d` mkb[^g]bfb]bg^ pbma ,++ f`*d` e^oZfblhe^ p^k^ ghm fhk^ ^__^\mbo^ maZg ma^ lZf^ ]hlZ`^l h_ mkb[^g]bfb]bg^ Zehg^ #OZ[) -( - Zg] Ab`) -( -=$) 23 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

9WU& *%*& @__^\ml h_ <$ fhghma^kZib^l Zg] =$ ]kn` \hf[bgZmbhgl hg ma^ phkf [nk]^g =hq iehml lahp ma^ f^]bZg gnf[^kl Zg] jnZkmbe^l h_ k^\ho^k^] Z]nem 6# SOIXUYZUSG pbma pabld^kl k^ik^l^gmbg` ,+ Zg] 4+ jnZgmbe^l) Bkhni lbs^l p^k^ [^mp^^g _bo^ Zg] -0 ZgbfZel _hk ^o^kr ]hl^) & Zkbmaf^mb\ f^Zg6 %% <7+)+, ol) \hgmkhe6 % hnmeb^kl) G@Q' e^oZfblhe^6 O=?' mkb[^g]bfb]bg^) ?hlZ`^l lahpg bg ljnZk^ [kZ\d^ml Zk^ `bo^g bg f`*d` [h]r p^b`am)

24 1NGVZKX '

*&- 7WaQcaaW]\

Oahn`a Z\mbobmr h_ Zfb]Zgm^e Z`Zbglm \^kmZbg \^lmh]^l aZl Zek^Z]r [^^g \eZbf^] bg ma^ hkb`bgZe in[eb\Zmbhg V,2W' ]^mZbe^] k^lneml aZo^ ghm [^^g in[ebla^] _hk Zgr \^lmh]^ Ö Zm e^Zlm bg m^kfl h_ phkf \hngml) Oa^ hger in[eb\Zmbhgl ]^Zebg` pbma \^lmh]b\b]Ze Z\mbobmr h_ mkb[^g]bfb]bg^ Zk^ Z k^ob^p' f^gmbhgbg` ^__b\Z\r Z`Zbglm oZkbhnl \ab\d^g \^lmh]^l V,1W Zg] Z \ebgb\Ze _b^e] mkbZe k^ihkmbg` lhf^ ^__^\ml hg ?GKTOG lii) V-1W) C^k^ p^ ]^fhglmkZm^ Z \e^Zk ]hl^(]^i^g]^gm Zgmb( \^lmh]Ze Z\mbobmr h_ mkb[^g]bfb]bg^ Z`Zbglm ma^ fhnl^ [be^ ]n\m mZi^phkf 6# SOIXUYZUSG ) Oak^^ mk^Zmf^gml pbma ]hlZ`^l h_ 0+ f`*d` Zg] ,++ f`*d` [h]r p^b`am Z\ab^o^] g^Zker \hfie^m^ Zg] \hfie^m^ iZkZlbm^ \e^ZkZg\^' k^li^\mbo^er) Dg kh]^gml ma^l^ ]hlZ`^l Zk^ bg ma^ fb]]e^ kZg`^ h_ ma^ a^m^kh`^gb\ li^\mknf h_ ]hlZ`^l maZm Zk^ Zelh ^__^\mbo^ Z`Zbglm g^fZmh]^l Zg] mk^fZmh]^l' lmZkmbg` pbma , ! 0+ f`*d` Z`Zbglm :# HXGYOROKTYOY bg kZml Zg] ^g]bg` pbma 1 ! .++ f`*d` Z`Zbglm ?# YVOXGROY bg fb\^ #OZ[) -( ,$' bg]b\Zmbg` maZm mkb[^g]bfb]bg^ fb`am bg]^^] aZo^ Z ab`a ihm^gmbZe Zl [khZ](li^\mknf Zgma^efbgmb\ Zelh mZk`^mbg` \^lmh]^l) Nm^bgfZgg KZ GR# V-1W ]^fhglmkZm^] Z ab`a^k ^__b\Z\r h_ mkb[^g]bfb]bg^ maZg h_ Ze[^g]Zshe^ Z`Zbglm ?GKTOG lii) bg anfZgl Z_m^k lbg`e^ hkZe mk^Zmf^gm [nm \nk^ kZm^l _hk [hma ]kn`l p^k^ mhh ehp #11)2 _hk mkb[^g]bfb]bg^$ _hk Z khnmbg^ nl^ Z`Zbglm anfZg mZ^gbZlbl) Oa^k^_hk^' ma^r ln``^lm^] ^oZenZmbg` ma^ ^__b\Z\r h_ fnembie^(]hl^ mk^Zmf^gml pbma mkb[^g]bfb]bg^ mh \nk^ anfZg bgm^lmbgZe mZ^gbZlbl Zg] bg_^\mbhgl pbma ># YZKXIUXGROY ) Oanl' ma^ ^q\^ee^gm \nk^ kZm^l h[l^ko^] a^k^ pbma mak^^ \hgl^\nmbo^ mk^Zmf^gml \hkkh[hkZm^ maZm fnembie^ mk^Zmf^gml lahne] [^ \hglb]^k^] Zl nl^_ne l\a^f^ _hk mk^Zmf^gml h_ anfZg a^efbgmabZl^l Zemahn`a mabl phne] h_ \hnkl^ lb`gb_b\Zgmer bg\k^Zl^ [hma \hlml Zg] fZgZ`^f^gm ^__hkml) Okb[^g]bfb]bg^ bl kZib]er f^mZ[hebl^] mh ]aMl aZl [^^g ]^fhglmkZm^] mh [^ \kn\bZe _hk mkb[^g]bfb]bg^ Zg] e^oZfblhe^ Z\mbobmr OT \OZXU V-.W) Okb[^g]bfb]bg^ Zg] ]aM `^g^l aZo^ [^^g bfieb\Zm^] bg k^lblmZg\^ mh Zfb]Zgm^e Zg] ]aM) Dg ma^ mk^fZmh]^ 1# YOTKTYOY ' OT \OZXU ^qi^kbf^gml k^o^Ze^] lbfbeZk Z\mbobmr h_ ]

Z\mbo^ Zm Zee Z`Zbglm 6# SOIXUYZUSG Zm mpb\^ ma^ \hg\^gmkZmbhg maZm bl ln__b\b^gm _hk _nee Z\mbobmr h_ mkb[^g]bfb]bg^) Oph ]b__^k^gm ^qieZgZmbhgl lahne] [^ \hglb]^k^] mh ^qieZbg ma^l^ ZiiZk^gmer \hg_eb\mbg` k^lneml) Abklm' ma^ fh]^ h_ Z\mbhg h_ mkb[^g]bfb]bg^ fb`am ]b__^k [^mp^^g g^fZmh]^l Zg] mk^fZmh]^l hg hg^ lb]^ Zg] \^lmh]^l hg ma^ hma^k lb]^) N^\hg]er' ma^ ehp^k ar]khiah[b\bmr h_ ]nkk^gmer' dghpe^]`^ Z[hnm ieZmra^efbgma Z\^mre\ahebg^ k^\^imhkl bl hger o^kr liZkl^) @o^g _hk >INOYZUYUSG lii) hger mak^^ o^kr Zmrib\Ze Z\^mre\ahebg^ k^\^imhkl aZo^ [^^g ]^l\kb[^] V..' ./W' Zg] Z m=GaMl bg \^lmh]^l maZm Zk^ mkb[^g]bfb]bg^ l^glbmbo^ [nm e^oZfblhe^ bgl^glbmbo^' #bb$ ab`aer bg^__^\mbo^ nimZd^ h_ e^oZfblhe^ [r \^lmh]^l hk #bbb$ Z \hfie^m^er ]b__^k^gm fh]^ h_ Z\mbhg h_ mkb[^g]bfb]bg^ bg \^lmh]^l maZg bg g^fZmh]^l) Chp^o^k' lbg\^ ma^ <>aM Z`hgblm irkZgm^e bl dghpg mh [^ Z\mbo^

3, 1NGVZKX '

Z`Zbglm ma^ ^jnbg^ \^lmh]^l /TUVRUIKVNGRG lii) V.3' .4W' \hf[bgZmbhgl h_ mkb[^g]bfb]bg^ pbma irkZgm^e lahne] [^ ^oZenZm^] bg _nmnk^ ^qi^kbf^gml) D_ Z \hfie^m^er ]b__^k^gm fh]^ h_ Z\mbhg h_ mkb[^g]bfb]bg^ bg \^lmh]^l bl \hglb]^k^]' mkb[^g]bfb]bg^ f^mZ[heblf lahne] [^ mZd^g bgmh Z\\hngm) Okb[^g]bfb]bg^ bl ghm ]^m^\mZ[e^ bg ieZlfZ lZfie^l lbg\^ bm bl o^kr kZib]er \e^Zo^] bgmh ]$) Dg ieZlfZ lZfie^l' hger ] Zk^ ]^m^\mZ[e^ nlbg` ab`a i^k_hkfZg\^ ebjnb] \akhfZmh`kZiar _heehp^] [r fZll li^\mkhf^mkr V,4W) Oabl lbmnZmbhg fb`am [^ ]b__^k^gm bg ma^ `Zlmkhbgm^lmbgZe lrlm^f lbg\^ lfZee Zfhngml h_ mkb[^g]bfb]bg^ aZo^ [^^g lahpg mh [^ ^q\k^m^] pbma ma^ _Z^\^l V,1W) Dg \hgmkZlm mh ] Zk^ bgZ\mbo^ Z`Zbglm g^fZmh]^l # :# GSKXOIGT[Y ' :# HXGYOROKTYOY $ Zg] mk^fZmh]^l #1# YOTKTYOY $ V-4' /+W) Nbg\^ mkb[^g]bfb]bg^ bl o^kr kZib]er f^mZ[hebl^] mh ]

3- 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

*&. 6]\QZcaW]\a

Oa^ ik^l^gm lmn]r ikhob]^l _hk ma^ _bklm mbf^ ^qi^kbf^gmZe ^ob]^g\^ _hk Z ab`a ^__b\Z\r h_ mkb[^g]bfb]bg^ Z`Zbglm \^lmh]^l bg Z \hgmkhee^] eZ[hkZmhkr lrlm^f) Oa^ ^q\^ee^gm \nk^ kZm^l h[l^ko^] a^k^ pbma mak^^ \hgl^\nmbo^ mk^Zmf^gml h_ 0+ f`*d` mkb[^g]bfb]bg^ \hkkh[hkZm^ ma^ ln``^lmbhg h_ Nm^bgfZgg KZ GR# V-1W maZm fnembie^ mk^Zmf^gml lahne] [^ \hglb]^k^] Zl nl^_ne l\a^f^ _hk mk^Zmf^gml h_ a^efbgmabZl^l) Oa^ _Z\m maZm hger mkb[^g]bfb]bg^ [nm ghm bml g^fZmb\b]Ze f^mZ[hebm^ ]

*&/ 9W\O\QWOZ ac^^]`b

Oa^ ik^l^gm^] lmn]r pZl _ng]^] [r ma^ =Zr^k C^Zema>Zk^ Zk^

*&0 6]\TZWQb ]T W\bS`Sab

<) CZk]^k Zg] >) R^es Zk^ ^fiehr^^l h_ =Zr^k C^Zema>Zk^ Zk^ Zk^

3. 1NGVZKX '

*&1 ESTS`S\QSa

,) Chm^s KE' =ng]r ?abmlneh G' >ahp E' GZqfbgZkZrZg M' Hb\aZn] >' =^mahgr E' >hkk^Z(Jebo^bkZ M' NananZ S' A^gpb\d <' NZobheb G' -++1' C^efbgma Dg_^\mbhgl5 Nhbe( mkZglfbmm^] C^efbgma Dg_^\mbhgl Zg] N\ablmhlhfbZlbl' Dg5 EZfblhg ?O' =k^fZg EB' H^ZlaZf eZ^lhg H' @oZgl ?=' EaZ K' Hbeel <' Hnl`kho^ K #@]l)$' ?bl^Zl^ \hgmkhe ikbhkbmb^l bg ]^o^ehibg` \hngmkb^l) Jq_hk] Pgbo^klbmr Kk^ll' I^p Thkd' /12(/3-) -) >khfimhg ?RO' Rhke] C^Zema Jk`ZgbsZmbhg' -++1' Kk^o^gmbo^ \a^fhma^kZir bg anfZg a^efbgmabZlbl5 \hhk]bgZm^] nl^ h_ Zgma^efbgmab\ ]kn`l bg \hgmkhe bgm^ko^gmbhgl5 Z fZgnZe _hk a^Zema ikh_^llbhgZel Zg] ikh`kZff^ fZgZ`^kl) Rhke] C^Zema Jk`ZgbsZmbhg' B^g^oZ' ,(1-) .) ?bZpZkZ G' OkZhk^ HJ' =Z]cb <' =bllZg T' ?hnf[bZ F' BhbmZ NA' FhgZm^ G' Hhngdhkh F' NZkk H?' N^\d ab\h H' GhoZmh M' Bhf^s @' =Zkk^mh HG' >hhi^k KE' -++3' DfiZ\m h_ ehg`(m^kf mk^Zmf^gm pbma bo^kf^\mbg hg ma^ ik^oZe^g\^ Zg] bgm^glbmr h_ lhbe( mkZglfbmm^] a^efbgma bg_^\mbhgl) KGhN I^`e Okhi ?bl -' ^-4.) 0) Rbgg^g H' KeZblb^k Zg bo^kf^\mbg fZll mk^Zmf^gml ^ebfbgZm^ hg\ah\^k\bZlbl bg <_kb\Z: =nee Rhke] C^Zema Jk`Zg 3+' .3/(.4,) 1) CZk]^k <' -++-' >a^fhma^kZi^nmb\ ZiikhZ\a^l mh mk^fZmh]^l #^q\^im l\ablmhlhf^l$ Zg] \^lmh]^l5 \nkk^gm e^o^e h_ dghpe^]`^ Zg] hnmehhd) KZkZlbmhe M^l 33' 032(04+) 2) >kZb` K' Dmh <' -++2' Dgm^lmbgZe \^lmh]^l) >nkk Jibg Dg_^\m ?bl -+' 0-/(0.-) 3) ?hkgr K' KkZ^m I' ?^\d^kl I' BZ[kb^e N' -++4' @f^k`bg` _hh]([hkg^ iZkZlbm^l) Q^m KZkZlbmhe ,1.' ,41(-+1) 4) Hbg ?T' ,44+' >^lmh]^ bg_^\mbhgl bg Fhk^Z) FblZ^g`\ang`aZd >aZi\ab -3' ,-.(,//) ,+) ?^ieZs^l K' oZg FgZi^g A' N\ap^b`^k <' Jo^k`ZZnp K<' -+,,' Mhe^ h_ i^m ]h`l Zg] \Zml bg ma^ mkZglfbllbhg h_ a^efbgmab\ shhghl^l bg @nkhi^' pbma Z _h\nl hg ^\abgh\h\\hlbl Zg] mhqh\Zkhlbl) Q^m KZkZlbmhe ,3-' /,(0.) ,,) NZg`lm^k I>' -++,' HZgZ`bg` iZkZlbmb\b]^ k^lblmZg\^) Q^m KZkZlbmhe 43' 34(,+4)

3/ 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

,-) ?h^gah__ HE' >bheb ?' Pmsbg`^k E' -++3' KkZsbjnZgm^e5 f^\aZgblfl h_ Z\mbhg' k^lblmZg\^ Zg] g^p ]^kboZmbo^l _hk l\ablmhlhfbZlbl) >nkk Jibg Dg_^\m ?bl -,' 104(112) ,.) =k^ggZg BK' AZbkp^Zma^k D' Okn]`^mm <' Ch^r @' H\>hr' H\>hgobee^ H' H^Zg^r H' Mh[bglhg H' H\A^kkZg I' MrZg G' GZgnll^ >' Hhmmb^k G' ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) ,2) Rheep^[^k C' Ib^f^kl @' Aen\d^ R' (HN ?^m^kfbgZmbhg h_ V(#,( ?bf^mareZfbgh ^marebfbgh$Zgbebg^5 Z H^mZ[hebm^ h_ Okb[^g]bfb]bg^ bg CnfZg KeZlfZ) >akhfZmh`kZiabZ 13' ,.4(,/-) ,4) TnZg B' Sn E' Ln O' RZg` =' UaZg` M' R^b >' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l M ? ,+' 3.(4+) -+) Ohfebglhg B' <' Rhh]l M<' ,430' Oa^ ^__^\ml h_ Zfb]Zgm^e #=' RZg` >' -++2' >ebgb\Ze h[l^koZmbhg hg 344 \abe]k^g bg_^\m^] pbma bgm^lmbgZe g^fZmh]^l Zg] mk^Zm^] pbma mkb[^g]bfb]bg^ ^gm^kb\ \hZm^] mZ[e^ml) Uahg``nh Eb Na^g` >ahg` Sn^ Tn Eb Na^g` >ahg` =bg` UZ Uab -0' .2-(.20)

30 1NGVZKX '

-.) Cn T' SbZh NC' ahee^m E' OZgg^k H' Pmsbg`^k E' -++2' @oZenZmbhg h_ ma^ OT \O\U Z\mbobmr h_ mkb[^g]bfb]bg^ Z`Zbglm >INOYZUYUSG SGTYUTO! 4GYIOURG NKVGZOIG! 1RUTUXINOY YOTKTYOY! Zg] ;VOYZNUXINOY \O\KXXOTO ) a^fhma^k 0,' ,+41(,+43) -1) Nm^bgfZgg K' Uahn SI' ?n UR' EbZg` ET' SbZh NC' Rn US' Uahn C' Pmsbg`^k E' -++3' Okb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ _hk mk^Zmbg` lhbe(mkZglfbmm^] a^efbgmal' >ZXUTM_RUOJKY YZKXIUXGROY Zg] ?GKTOG lii)5 hi^g(eZ[^e kZg]hfbs^] mkbZe) KGhN I^`e Okhi ?bl -' ^.--) -2) >nggbg`aZf GE' Jelhg K?' -+,+' ?^l\kbimbhg h_ 6_SKTURKVOY SOIXUYZUSG #Ihmmbg`aZf lmkZbg$5 Z \eZllb\Ze mZi^phkf fh]^e _hk k^l^Zk\a bg ma^ `^ghfb\ ^kZ) KZkZlbm Q^\mhkl .' ,-.) -3) =^gg^m @H' =^af >' =krZgm >' ,423' @__^\ml h_ f^[^g]Zshe^ Zg] e^oZfblhe^ hg m^mkZmarkb]bZ h_ 9KYUIKYZUOJKY IUXZO bg ma^ fhnl^) Dgm E KZkZlbmhe 3' /1.(/11) -4) SbZh NC' Sn^ E' Sn GG' Ua^g` L' LbZg` CL' UaZg` TI' -++4' Oa^ OT \OZXU Zg] OT \O\U ^__^\m h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Z`Zbglm 1RUTUXINOY YOTKTYOY ) KZkZlbmhe M^l ,+0' ,/42(,0+2) .+) Rhh]l M<' HZehg^ FH=' <' Ohfebglhg B' ,431' Oa^ @__^\ml h_ Zg E Uhhe 1/' ,.,+(,.,1) .,) Oahfilhg >N' H^mmkb\d ?A' ,43/' I^nkhfnl\neZk iarlbheh`r h_ 6_SKTURKVOY JOSOT[ZG Zg] 6# SOIXUYZUSG #>^lmh]Z$) KZkZlbmheh`r 34' 012(023) .-) >aZg\^ HM' HZglhnk O@' ,40.' < \hgmkb[nmbhg mh ma^ iaZkfZ\heh`r h_ fho^f^gm bg ma^ ebo^k _end^) =k E KaZkfZ\he >a^fhma^k 3' ,./(,.3) ..) =^gme^r BI' Ehg^l INOYZUYUSG ) B^g^ .-4' -2(.3)

31 3LLOIGI_ UL ZXOHKTJOSOJOTK GMGOTYZ 6_SKTURKVOY SOIXUYZUSG

./) =^gme^r BI' Ehg^l INOYZUYUSG ) KZkZlbmheh`r ,./' 3..(3/+) .0) MZ[[Zgb BC' BbefZg MC' FZ[bk D' Hhg]^e B' ,430' Oa^ mk^Zmf^gm h_ 4GYIOURUVYOY H[YQO bg_^\mbhg bg \abe]k^g5 Z \hfiZkblhg h_ mabZ[^g]Zshe^' f^[^g]Zshe^' e^oZfblhe^' irkZgm^e iZfhZm^' a^qrek^lhk\bghe Zg] m^mkZ\aehkh^mare^g^) OkZgl M Nh\ Okhi H^] Cr` 24' 0,.(0,0) .1) Nfbma H>' Na^kfZg ?H' -++4' BhZm f^]b\bg^' Rbe^r(=eZ\dp^ee' a^fhma^kZir h_ anfZg bgm^lmbgZe a^efbgmabZl^l5 Z k^ob^p' pbma iZkmb\neZk k^_^k^g\^ mh \hffngbmr mk^Zmf^gm) <]o KaZkfZ\he >a^fhma^k ,4' ,-4(,0/) .3) HZk\abhg]h <<' Rabm^ BR' Nfbma GG' M^bg^f^r^k >M' ?Zl\Zgbh EE' Ehaglhg @B' Nan`Zkm ED' -++1' >ebgb\Ze _b^e] ^__b\Z\r Zg] lZ_^mr h_ irkZgm^e iZfhZm^ iZlm^ #,4),. p*p irkZgm^e [Zl^$ Z`Zbglm /TUVRUIKVNGRG lii) bg gZmnkZeer bg_^\m^] ahkl^l) Q^m KZkZlbmhe ,.2' 4/(,+-) .4) M^bg^f^r^k >M' Cnm\a^gl ?@' @\d[eZ] RK' HZk\abhg]h <<' Nan`Zkm ED' -++1' ?hl^(\hg_bkfZmbhg lmn]b^l h_ ma^ \^lmh\b]Ze Z\mbobmr h_ irkZgm^e iZfhZm^ iZlm^ bg ahkl^l) Q^m KZkZlbmhe ,.3' -./(-.4) /+) Sn^ E' Pmsbg`^k E' UaZg` TI' OZgg^k H' F^bl^k E' SbZh NC' -++3' ' RZg` NC' RZg` NL' RZg` >' -++3' Okb[^g]bfb]bg^ ^gm^kb\ \hZm^] mZ[e^m bg mk^Zmf^gm h_ ,'-4- \Zl^l pbma bgm^lmbgZe g^fZmh]^ bg_^\mbhg((Z iaZl^ DQ \ebgb\Ze mkbZe) Uahg``nh Eb Na^g` >ahg` Sn^ Tn Eb Na^g` >ahg` =bg` UZ Uab -1' 1(4) /.) Rn US' AZg` TT' Gbn TN' -++1' @__^\m h_ Z gho^e ]kn` ( ^gm^kb\ \hZm^] mkb[^g]bfb]bg^ bg ma^ mk^Zmf^gm h_ bgm^lmbgZe g^fZmh]^ bg_^\mbhgl) Uahg``nh Eb Na^g` >ahg` Sn^ Tn Eb Na^g` >ahg` =bg` UZ Uab -/' -.(-1)

32 1NGVZKX '

//) Gb MC' BZh EC' RZg` NA' K^b TE' Na^g ET' TZg KH' Tbg BM' -+,,' @__^\m h_ hkZe Z]fbgblmkZmbhg h_ mkb[^g]bfb]bg^ Zm ]b__^k^gm ]hlZ`^l Z`Zbglm ?XOINOTKRRG YVOXGROY ^g\ZilneZm^] eZkoZ^ bg fb\^) Uahg``nh Eb Na^g` >ahg` Sn^ Tn Eb Na^g` >ahg` =bg` UZ Uab -4' ,,2(,-,) /0) F^bl^k E' Oab^fZgg F' @g]kbll T' Pmsbg`^k E' -++3' >ZXUTM_RUOJKY XGZZO 5 OT \OZXU Zg] OT \O\U Z\mbobmr h_ mkb[^g]bfb]bg^) KGhN I^`e Okhi ?bl -' ^,.1)

33 Chapter 3

In vitro efficacy of cyclooctadepsipeptides and aminophenylamidines alone and in combination against third-stage larvae and adult worms of Nippostrongylus brasiliensis and first-stage larvae of Trichinella spiralis

Kulke D., Krücken J., Demeler J., Harder, A., Mehlhorn, H., von Samson-Himmelstjerna G.

Parasitology Research 2012, 112 (1): 335-345.

http://dx.doi.org/10.1007/s00436-012-3141-1 1NGVZKX (

+ "2 9/753 STTWQOQg ]T QgQZ]]QbORS^aW^S^bWRSa O\R O[W\]^VS\gZO[WRW\Sa OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab bVW`R%abOUS ZO`dOS O\R ORcZb e]`[a ]T #/44367532-:086 *5)6/0/,26/6 O\R TW`ab%abOUS ZO`dOS ]T '5/+./2,00) 64/5)0/6

+&) 4Pab`OQb

Oa^ ik^l^gm lmn]r bgo^lmb`Zm^l ma^ OT \OZXU ^__b\Z\r h_ ]^kboZmbo^l h_ ma^ \r\ehh\mZ]^ilbi^imb]^l Zg] ma^ Zfbghia^greZfb]bg^l' pab\a Zk^ ikhfblbg` \Zg]b]Zm^l _hk ma^ ^oZenZmbhg h_ ma^ mk^Zmf^gm h_ anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) Oa^ ^__^\ml h_ ^fh]^ilb]^ Zg] KA,+--< Zl p^ee Zl h_ Zfb]Zgm^e' ]

@fh]^ilb]^ aZ] Z lb`gb_b\Zgmer ehp^k @> 0+ oZen^ maZg KA,+--< bg ma^ ?# YVOXGROY #+)+-233 ol) +)+031- `*fe$ Zg] ma^ :# HXGYOROKTYOY #+)+1,33 ol) +),/30 `*fe$ fhmbebmr ZllZrl [nm ghm bg ma^ Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZr pbma Z]nem :# HXGYOROKTYOY #+)+010+ ol) +)+1331 `*fe$) Rabe^ Zfb]Zgm^e lahp^] hger fbgbfZe hk Zm [^lm iZkmbZe bgab[bmbhg h_ g^fZmh]^ fhmbebmr Zg] Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ' mkb[^g]bfb]bg^ pZl g^Zker Zl ihm^gm Zl

] 0+ maZg mkb[^g]bfb]bg^ bg ma^ :# HXGYOROKTYOY G. fhmbebmr ZllZr #+)+0/4- ol) +)-+3+ `*fe$' ]b__^k^g\^l p^k^ ghm lb`gb_b\Zgm bg ma^ ?# YVOXGROY G, fhmbebmr ZllZr #+)2211 ol) ,),/0 `*fe$) Nnkikblbg`er' ghg^ h_ ma^ \hf[bgZmbhgl lahp^] bfikho^] ^__b\Z\r pa^g \hfiZk^] mh ma^ bg]bob]nZe ]kn`l bg\en]bg` e^oZfblhe^*mkb[^g]bfb]bg^' pab\a aZo^ ik^obhnler [^^g k^ihkm^] mh Z\m lrg^k`blmb\Zeer Z`Zbglm /# IK_RGTOI[S )

4+ 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

+&* <\b`]RcQbW]\

Nhbe(mkZglfbmm^] a^efbgmahl^l #NOCl$ Zk^ Zfhg` ma^ fhlm ik^oZe^gm Zg] i^klblm^gm iZkZlbmb\ bg_^\mbhgl bg iho^kmr(lmkb\d^g Zg] k^lhnk\^(\hglmkZbg^] k^`bhgl _k^jn^gmer _hng] ng]^k ihhk ar`b^gb\ \hg]bmbhgl bg fZgr k^`bhgl h_ ln[(NZaZkZg <_kb\Z' ma^ abgZ Zg] @Zlm

4, 1NGVZKX ( k^\hglmbmnm^ ^fh]^ilb]^ l^glbmbobmr bg 1# KRKMGTY NGJ(, ehll(h_(_ng\mbhg fnmZgml V,1W) abgZ bg -++/ V,2W) Okb[^g]bfb]bg^ bl Z lrff^mkb\Ze ]bZfb]bg^ ]^kboZmbo^ h_ Zfb]Zgm^e' pab\a pZl k^ihkm^] mh [^ ^__b\Z\bhnl' nlbg` ab`a Zg] fnembie^ ]hlZ`^l' Z`Zbglm l^o^kZe g^fZmh]^l Zg] ieZmra^efbgmal bg ma^ eZm^ ,42+l V,3W) Okb[^g]bfb]bg^ bl ab`aer ^__^\mbo^ Z`Zbglm Z [khZ] kZg`^ h_ g^fZmh]^l Zg] Zm e^Zlm lhf^ mk^fZmh]^l Zg] \^lmh]^l bg kh]^gml' \ab\d^g' ]h`l Zg] anfZgl bg _Zbker ehp ]hlZ`^l V,2' ,4' -+W) =hma Zfb]Zgm^e Zg] mkb[^g]bfb]bg^ Zk^ kZib]er f^mZ[hebl^] mh ]aMl' ln``^lmbg` maZm bm laZk^l bml fh]^ h_ Z\mbhg pbma e^oZfblhe^ Zg] irkZgm^e V-/W) ?^libm^ ZiiZk^gmer b]^gmb\Ze mZk`^ml' lrg^k`blmb\ ^__^\ml h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ aZo^ k^\^gmer [^^g k^ihkm^] Z`Zbglm /# IK_RGTOI[S pa^g ^qihl^] mh ma^l^ ]kn`l OT \OZXU hk mk^Zm^] OT \O\U V-.W) Oh _nkma^k \hkkh[hkZm^ ma^ ihm^gmbZe h_ ^fh]^ilb]^ Zg] KA,+--< Zl p^ee Zl h_ Zfb]Zgm^e' ]

4- 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

+&+ @ObS`WOZa O\R [SbV]Ra

3ZNOIGR YZGZKSKTZ Zk^

2X[MY Zk^ M Bf[C ! >h) FB #FZkelkna^' B^kfZgr$' Zg] mkb[^g]bfb]bg^ pZl h[mZbg^] _khf NaZg]hg` SbganZ KaZkfZ\^nmb\Ze >hfiZgr Gbfbm^] #Ub[h' K^hie^"l M^in[eb\ h_ >abgZ$) ngmbe _nkma^k nl^) Ahk Zee OT \OZXU ZllZrl' m^lm \hfihng]l p^k^ ]bllheo^] bg ]bf^mare lneiahqb]^ #?HNJ$ Zm Z \hg\^gmkZmbhg h_ -+'+++ `*fe Zg] l^kbZe ]benmbhgl p^k^ i^k_hkf^] bg ?HNJ k^lnembg` bg lmh\d lhenmbhgl h_ -'+++' -++' -+' Zg] - `*fe) Nmh\d lhenmbhgl p^k^ lmhk^] Zm / |> ngmbe ma^r p^k^ ]benm^] ,5-++ pbma phkf f^]bnf #-+ `*e =Z\mh >Zlbmhg^' ,+ `*e r^Zlm ^qmkZ\m' 0 `*e

`en\hl^' +)3 `*e FC -KJ /' +)3 `*e F -CKJ /' ,+ `*fe lblhfr\bg Zg] , `*fe \ehmkbfZshe^' iC 2 )-$) AbgZe ]kn` \hg\^gmkZmbhgl p^k^ ,++' ,+' ,' +), Zg] +)+, `*fe bg +)0 ?HNJ) Dg Z]]bmbhg mh bg]bob]nZe ]kn`l' \hf[bgZmbhgl h_ KA,+--< ienl ]

/TOSGRY A^fZe^ eZ[hkZmhkr hnm[k^] RblmZk kZml #Cl]>i[5RP$ p^k^ ink\aZl^] _khf CZkeZg I^ma^keZg]l Zm Zg Z`^ h_ 1(,+ p^^dl pbma Z [h]r p^b`am h_ ,-0(,20 `) A^fZe^ eZ[hkZmhkr hnm[k^] fb\^ #Cl]Rbg5>AR(,$ p^k^ ink\aZl^] #CZkeZg' I^ma^keZg]l$ Zm Zg Z`^ h_ /(3 p^^dl pbma Z [h]r p^b`am h_ ,0(-+ `)

4. 1NGVZKX (

:# HXGYOROKTYOY OT XGZY Oa^ eb_^ \r\e^ h_ :# HXGYOROKTYOY pZl fZbgmZbg^] Zl ]^l\kb[^] ik^obhnler V,.W) =kb^_er' mak^^ _^fZe^ Cl]>i[5RP kZml p^k^ ln[\nmZg^hnler bg_^\m^] obZ ma^ gn\aZe _he] pbma +). fe

Mbg`^k"l lhenmbhg #,,3)/ fH IZ>e' /)2 fH F>e' -)0- fH >Z>e -' ,),3 fH H`NJ /'

,),3 fH FC -KJ /' -0)+, fH IZC>J .' iC 2)/$ \hgmZbgbg` ZiikhqbfZm^er -0++ bg_^\mbo^ G.) Nbq ]Zrl V#O#! ma^ [hmmhf h_ Z HZ\khehg Ä \Z`^ pZl \ho^k^] pbma fhblm^g^] _bem^k iZi^k' Zg] ma^ ZgbfZel p^k^ ieZ\^] hg Z _ehhk `kZm^ _hk -/ a) AZ^\^l \hgmZbgbg` ^``l p^k^ \hee^\m^] _khf ma^ _bem^k iZi^k' fbq^] pbma Z lenkkr h_ \aZk\hZe Zg] \aZk\hZe(_bem^k^] pZm^k mh Z\ab^o^ Z iZlmr m^qmnk^) Oa^ fbqmnk^ pZl ieZ\^] hg pZm\a `eZll^l bg Z pZm^k(_bee^] anfb] \aZf[^k Zg] bg\n[Zm^] Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr _hk _bo^ ]Zrl mh Zeehp aZm\abg` h_ G,' fb`kZmbhg bgmh ma^ lnkkhng]bg` pZm^k Zg] _nkma^k ]^o^ehif^gm) GZkoZ^ p^k^ \hee^\m^] bg Zg @ke^gf^r^k _eZld Zg] _nkma^k bg\n[Zm^] _hk Zghma^k mph ]Zrl Zm khhf m^fi^kZmnk^ mh ^glnk^ \hfie^m^ ]^o^ehif^gm h_ bg_^\mbo^ G.) GZkoZ^ p^k^ pZla^] Zg] ma^g nl^] _hk bg_^\mbhg h_ kZml Zg] _hk OT \OZXU fhmbebmr ZllZrl) Jg ]Zr 2 V#O#! kZml p^k^ ^nmaZgbl^] [r \Zk[hg ]bhqb]^ ln__h\Zmbhg) <_m^k g^\khilr' lfZee bgm^lmbg^l p^k^ ]bll^\m^] Zg] \nm hi^g ehg`bmn]bgZeer) ?nh]^gnf Zg] bg`^lmZ p^k^ mkZgl_^kk^] bgmh Z [Z` \hglblmbg` h_ _bo^ `Zns^ eZr^kl Zg] ang` bgmh Z \hgb\Ze _eZld _bee^] pbma Mbg`^k"l lhenmbhg #ienl ,+ `*fe lblhfr\bg Zg] , `*fe \ehmkbfZshe^$) M^\ho^k^] Z]nem phkfl p^k^ mkZgl_^kk^] bgmh phkf f^]bnf Zg] d^im Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr ngmbe nl^ bg ma^ Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZr' [nm _hk Z fZqbfnf h_ -/ a)

?# YVOXGROY OT SOIK KZllZ`^ h_ ?# YVOXGROY pZl i^k_hkf^] Zl ]^l\kb[^] ik^obhnler V-0W) =kb^_er' mak^^ _^fZe^ Cl]Rbg5>AR(, fb\^ p^k^ hkZeer bg_^\m^] pbma +)0 fe Mbg`^k"l lhenmbhg #ienl ,+ `*fe lblhfr\bg Zg] , `*fe \ehmkbfZshe^$ \hgmZbgbg` .++ _k^laer blheZm^] eZkoZ^) <_m^k mak^^ p^^dl mh lbq fhgmal V#O#! fb\^ p^k^ ^nmaZgbl^] [r \Zk[hg ]bhqb]^ ln__h\Zmbhg) >Zk\Zll^l p^k^ ahfh`^gbl^] nlbg` Z fbg\^k) Oa^ fnl\neZmnk^ pZl mk^Zm^] pbma Zkmb_b\bZe ]b`^lmbo^ cnb\^ #2), `*e i^ilbg bg .++ fe +)1 ar]kh\aehkb\ Z\b]$ Zm .2 |> _hk /+ fbg mh ^g\rlm eZkoZ^ _khf ma^bk ahlm \^eel) GZkoZ^ p^k^ l^iZkZm^] _khf k^fZbgbg` ]^[kbl [r [Z^kfZgblZmbhg makhn`a Z lmZ\d h_ -++(' ,++( Zg] 3+( f lb^o^l Zg] \hee^\m^] _khf ma^ lnk_Z\^ h_ ma^ eZmm^k) <_m^k mak^^ pZla \r\e^l nlbg` Mbg`^k"l lhenmbhg' eZkoZ^ \hne] [^ nl^] _hk bg_^\mbhg h_ fb\^) Ahk nlZ`^ bg

4/ 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY ma^ fhmbebmr ZllZr' eZkoZ^ p^k^ mkZgl_^kk^] bgmh phkf f^]bnf Zg] d^im Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr ngmbe _nkma^k nl^' [nm _hk Z fZqbfnf h_ -/ a)

7T \OZXU GYYG_Y

?# YVOXGROY 8& GTJ :# HXGYOROKTYOY 8( SUZOROZ_ GYYG_Y $ phkf f^]bnf i^k p^ee) Oph ]kn`l p^k^ m^lm^] i^k ieZm^ pbma ^Z\a \hg\^gmkZmbhg bg ]nieb\Zm^) Nbq g^`Zmbo^ \hgmkhel #phkf f^]bnf pbma +)0 ?HNJ$ p^k^ ZepZrl kng bg iZkZee^e mh ma^ ZllZrl hg Zg ^qmkZ ieZm^) @qZ\mer -+ eZkoZ^ p^k^ Z]]^] bgmh ^Z\a p^ee Zg] ma^g bg\n[Zm^] Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr _hk 2- a # ?# YVOXGROY G,$ Zg] -/ a # :# HXGYOROKTYOY G.$' k^li^\mbo^er) Hhmbebmr pZl ma^g ^oZenZm^] nlbg` Zg bgo^kl^ fb\khl\hi^ pbma Z m^fi^kZmnk^(\hgmkhee^] h[c^\m lmZ`^ #.2 |>$) GZkoZ^ p^k^ \Zm^`hkbl^] Zl iZkZerl^] pa^g ma^r lahp^] hger fbgbfZe fho^f^gm h_ ma^ a^Z] Zg]*hk mZbe hk gh fho^f^gm Zg] Zl fhmbe^ pa^g ma^r ]blieZr^] lbfbeZk Z\mbobmr Zl bg g^`Zmbo^ \hgmkhel)

:# HXGYOROKTYOY GIKZ_RINUROTK KYZKXGYK YKIXKZOUT GYYG_ <\^mre\ahebg^ ^lm^kZl^ #<>a@$ bl dghpg mh [^ l^\k^m^] [r fZgr iZkZlbmb\ g^fZmh]^l' K#M# :# HXGYOROKTYOY ' ;KYUVNGMUYZUS[S lii) Zg] ?XOINUYZXUTM_R[Y lii # V-1' -2W ) Dm aZl Zelh [^^g lahpg maZm Zgma^efbgmb\l Zk^ Z[e^ mh bgab[bm l^\k^mbhg h_ <>a@ [r :# HXGYOROKTYOY V-3W) Oabl aZl [^^g nl^] mh l^m ni Z :# HXGYOROKTYOY <>a@ ZllZr V-4W nlbg` \hehnkbf^mkb\ ]^m^kfbgZmbhg h_ <>a@ Z\mbobmr V.+W bg ma^ \nemnk^ f^]bnf) Oanl' k^]n\mbhg h_ <>a@ Z\mbobmr pZl f^Zlnk^] bg ma^ ik^l^g\^ h_ Zgma^efbgmb\ ]kn`l mh jnZgmb_r ma^bk Z\mbobmr) ?kn` \hg\^gmkZmbhgl Zg] \hgmkhel p^k^ b]^gmb\Ze mh mahl^ nl^] bg ma^ fhmbebmr ZllZrl) Nbg\^ l^\k^mbhg h_ <>a@ bl `^g]^k Zg] [h]r p^b`am li^\b_b\ V.,W' mph _^fZe^ Zg] mak^^ fZe^ Z]nem phkfl p^k^ ieZ\^] bg ^Z\a p^ee \hgmZbgbg` , fe h_ ik^(pZkf^] f^]bnf pbma ]kn`l ienl o^ab\e^ Zg] bg\n[Zm^] Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr _hk _bo^ ]Zrl) a@ \e^Zo^l Z\^mremabh\ahebg^ bgmh Z\^mZm^ Zg] mabh\ahebg^ V.+W) Dg Z \hgl^\nmbo^ k^Z\mbhg' mabh\ahebg^ k^Z\ml pbma 0'0 $(]bmabh([bl#-( gbmkh[^gshb\ Z\b]$ mh mabhgbmkh[^gshZm^) Oabhgbmkh[^gshZm^ bl Z r^eehp ]r^ Zg] bml

40 1NGVZKX (

\hg\^gmkZmbhg \Zg [^ ]^m^kfbg^] [r f^Zlnkbg` ma^ Z[lhkimbhg Zm /+0 gf) Oa^ //+0 pZl f^Zlnk^] Z_m^k mph Zg] l^o^g fbgnm^l h_ bg\n[Zmbhg Zm MO nlbg` Zg @qi^km 41 ieZm^ k^Z]^k #a@ Z\mbobmr) Oa^ Zkbmaf^mb\ f^Zg h_ ,- gh ]kn` \hgmkhe p^eel pZl l^m mh ,++ Z\mbobmr' Zg] k^]n\mbhg h_ <>a@ Z\mbobmr bg i^k\^gmZ`^ k^eZmbo^ mh ma^ g^`Zmbo^ \hgmkhe pZl \Ze\neZm^] _hk Zee m^lm \hfihng] \hg\^gmkZmbhgl) Rbmabg Zg ZllZr' ^o^kr ]kn` \hg\^gmkZmbhg pZl i^k_hkf^] bg ]nieb\Zm^' Zg] ma^ lh_mpZk^ k^ihkm^] ma^ f^Zg h_ ma^l^ ]nieb\Zm^l)

1GRI[RGZOUT UL JUYK"XKYVUTYK I[X\KY GTJ YZGZOYZOIGR GTGR_YOY Ahk Zee ZllZrl' bgab[bmbhg h_ g^fZmh]^ Z\mbobmr # O#K# fhmbebmr hk l^\k^mbhg h_ <>a@$ pZl iehmm^]

Z`Zbglm ma^ eh` ,+ h_ ma^ ]kn` \hg\^gmkZmbhgl) ?ZmZ p^k^ _bm [r Z _hnk(iZkZf^m^k eh`blmb\ fh]^e nlbg` BkZiaKZ] Kkblf 0)+.) Ohi Zg] [hmmhf p^k^ \hglmkZbg^] mh oZen^l [^mp^^g + Zg] ,++ )

@> 0+ oZen^l p^k^ \hfiZk^] nlbg` ma^ ^qmkZ lnf h_ ljnZk^l 4 m^lm bfie^f^gm^] Zl ]^_Znem _hk mabl mri^ h_ ZgZerlbl bg BkZiaKZ] Kkblf) Dg \Zl^l pa^k^ fnembie^ m^lml p^k^ i^k_hkf^] #\hfiZkblhg h_ mak^^ Z fbghia^greZfb]bg^l Zg] \hfiZkblhg h_ ]kn` \hf[bgZmbhgl pbma [hma bg]bob]nZe ]kn`l$' < oZen^l p^k^ \hkk^\m^] nlbg` ma^ =hg_^kkhgbÖChef^l ZiikhZ\a)

41 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

+&, ESacZba

?# YVOXGROY 8& SUZOROZ_ GYYG_ <_m^k bg\n[Zmbhg _hk 2- a' fhmbebmr h_ ?# YVOXGROY G, bg g^`Zmbo^ \hgmkhel kZg`^] [^mp^^g 40)++ É /)/2 Zg] 41)12 É /)+3 ) Oa^ ^__^\ml h_ e^oZfblhe^' ma^ \r\ehh\mZ]^ilbi^imb]^l ^fh]^ilb]^ Zg] KA,+--<' ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]

OZ[) .( , lnffZkbl^l @> 0+ #pbma 40 \hg_b]^g\^ bgm^koZel #>D$ $ Zg] \h^__b\b^gml h_ - ]^m^kfbgZmbhg # = $ oZen^l Zg] k^ihkml < oZen^l _hk \hfiZkblhgl [^mp^^g @> 0+ oZen^l)

Oa^ \hfiZkblhg h_ ma^ @> 0+ oZen^l h_ ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^ k^o^Ze^] Z lb`gb_b\Zgm ]b__^k^g\^ pbma ^fh]^ilb]^ lahpbg` Z aZe_(fZqbfZe ^__^\m Zm Z -),(_he] ehp^k \hg\^gmkZmbhg maZg KA,+--< #Ab`) .( ,Z' OZ[) .( ,$)

\Ze\neZm^] _hk Zfb]Zgm^e bg mabl ZllZr) Ih lb`gb_b\Zgm ]b__^k^g\^ bg @> 0+ oZen^l pZl h[l^ko^] [^mp^^g mkb[^g]bfb]bg^ Zg] ] 0+ oZen^ maZg Zm e^Zlm hg^ h_ ma^ bg]bob]nZe ]kn`l bg ma^ \hf[bgZmbhg) Dg iZkmb\neZk' ma^ \hf[bgZmbhgl h_ KA,+--< pbma ]

Zg] e^oZfblhe^ aZ] gh lb`gb_b\Zgmer ehp^k @> 0+ maZg mkb[^g]bfb]bg^ Zehg^ #Ab`) .( ,\(^$)

42 1NGVZKX (

GOP& +%)& >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn` \hf[bgZmbhgl bg ma^ ?# YVOXGROY G, fhmbebmr ZllZr

O * 6][^]c\Ra 86 -( eWbV 1-% 6< % dOZcS & !W\ !U'[Z" 8[]RS^aWRS +)+-233 +)++.3 #ol) KA,+--<$ +)42,1 #+)+,34+(+)+/,,-$

C9)(**4 +)+031- +)++.3 #ol) ^fh]^ilb]^$ +)410/ #+)+.31+(+)+34+.$ ?SdO[Wa]ZS -),0/ +)421- #,)031(-)4-1$ 4[WRO\bSZ g] [ g] [ g] [

R4@7 +)2211 +),-01 #ol) mkb[^g]bfb]bg^$ +)4/21 #+)/,.-(,)/1+$

G`WPS\RW[WRW\S ,),/0 +),-01 #ol) ]

C9)(**4# +),+-0 7+)+++- #ol) mkb[^g]bfb]bg^$ +)4244 G`WPS\RW[WRW\S #+)+3/+/(+),-/4$ +)++2- #ol) KA,+--<$

?SdO[Wa]ZS# ,)+/- +)+++1 #ol) e^oZfblhe^$ +)42++ b`WPS\RW[WRW\S #+)2,1+(,)0,1$ +)1-0. #ol) mkb[^g]bfb]bg^$

' Kk^l^gm^] Zk^ ma^ f^Zg @> 0+ oZen^l pbma ma^ 40 >D Zg] = Zl p^ee Zl < oZen^l' _hk Z ]^m^kfbgZmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l) Nb`gb_b\Zgm ]b__^k^g\^ bg @> 0+ mh ]kn` bg [kZ\d^ml) < oZen^l p^k^ \hkk^\m^] _hk fnembie^ m^lmbg` nlbg` ma^ =hg_^kkhgbÖChef^l f^mah]) [Ihm ]^m^kfbg^] ]n^ mh Zf[b`nhnl \nko^ _bm _hk Zfb]Zgm^e lbg\^ hger iZkmbZe bgab[bmbhg pZl h[mZbg^] Zm ab`a Zfb]Zgm^e \hg\^gmkZmbhgl)

43 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

100 PF1022A 100 PF1022A+dAMD 90 Emodepside 90 PF1022A 80 80 dAMD 70 70 60 60 50 50 40 40 30 30 20 20 Paralysed larvae [%] 10 a Paralysed larvae [%] 10 c 0 0 -6 -5 -4 -3 -2 -1 0 1 2 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml] log 10 anthelmintic [µg/ml] 100 Tribendimidine 100 PF1022A+Tribendimidine 90 Amidantel 90 PF1022A 80 dAMD 80 Tribendimidine 70 70 60 60 50 50 40 40 30 30 20 20 Paralysed larvae [%] 10 b Paralysed larvae [%] 10 d 0 0 -6 -5 -4 -3 -2 -1 0 1 2 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml] log 10 anthelmintic [µg/ml] 100 Tribendimidine+Levamisole 90 Tribendimidine 80 Levamisole 70 60 50 40 30 20 Paralysed larvae [%] 10 e 0 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml]

9WU& +%)& ?# YVOXGROY G, fhmbebmr ZllZr

?ZmZ p^k^ ^qik^ll^] Zl bgab[bmbhg h_ ma^ gnf[^k h_ fhmbe^ eZkoZ^ bg ]kn`l Zg] \hgmkhel k^eZmbo^ mh ma^ f^Zg h_ ma^ o^ab\e^ \hgmkhel) ?hl^(k^lihgl^ \nko^l Zk^ lahpg _hk Z$ ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^6 [$ ma^ Zfbghia^greZfb]bg^ ]^kboZmbo^l mkb[^g]bfb]bg^' Zfb]Zgm^e Zg] ]

44 1NGVZKX (

:# HXGYOROKTYOY 8( SUZOROZ_ GYYG_Y Hhmbebmr bg g^`Zmbo^ \hgmkhel bg ma^ :# HXGYOROKTYOY G. fhmbebmr ZllZr kZg`^] [^mp^^g 4-)0+ É 0)-/ Zg] 4-)0+ É 3)-- ) Oa^ ^__^\ml h_ Zfb]Zgm^e' ]

NbfbeZk mh ma^ k^lneml h_ ma^ ?# YVOXGROY fhmbebmr ZllZr' ma^ @> 0+ _hk ^fh]^ilb]^ pZl Z[hnm

-)/(_he] ehp^k maZg ma^ @> 0+ _hk KA,+--< # < 7+)+++,$)

^qmkZiheZmbhg k^lnembg` bg Z o^kr pb]^ 40 >D _hk ma^ @> 0+ oZen^) Dg \hfiZkblhg mh mkb[^g]bfb]bg^ Zg] ] 0+ oZen^ pZl Z[hnm 13+( Zg] -0++(_he] ab`a^k' k^li^\mbo^er # < 7+)+++.$) Oa^ khn`aer .).(_he] ]b__^k^g\^ [^mp^^g mkb[^g]bfb]bg^ Zg] ] 0+ _khf KA,+--< Zehg^' Zg] ma^

\hf[bgZmbhg h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ ^o^g aZ] Z lb`gb_b\Zgmer ab`a^k @> 0+ oZen^ maZg mkb[^g]bfb]bg^ Zehg^ # <8+)++--$)

,++ 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

GOP& +%*& >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn` \hf[bgZmbhgl bg ma^ :# HXGYOROKTYOY G. fhmbebmr ZllZr

O * 6][^]c\Ra 86 -( eWbV 1-% 6< % dOZcS & !W\ !U'[Z" 8[]RS^aWRS +)+1,33 7+)+++, #ol) KA,+--<$ +)43-- #+)+0+,,(+)+21/,$

C9)(**4 +),/30 7+)+++, #ol) ^fh]^ilb]^$ +)4140 #+)+43.(+)--//$ ?SdO[Wa]ZS -)+04 +)404, #,)/./(-)401$

4[WRO\bSZ P ,/,)0 7+)+++. #ol) ]

R4@7 +)+0/4- 7+)+++. #ol) Zfb]Zgm^e$ +)41,4 +)+.4/1(+)+21/1$ +)+++4 #ol) mkb[^g]bfb]bg^$

G`WPS\RW[WRW\S +)-+3+ 7+)+++. #ol) Zfb]Zgm^e$ +)400+ #+),,/2(+).22,$ +)+++4 #ol) ]

C9)(**4# +)+1.34 +)+/,3 #ol) KA,+--<$ +)4040 R4@7 #+)+/,++(+)+4403$ +)0034 #ol) ]

C9)(**4# +)+24+3 7+)+++- #ol) mkb[^g]bfb]bg^$ +)43,- G`WPS\RW[WRW\S #+)+10,3(+)+4040$ +)+344 #ol) KA,+--<$

?SdO[Wa]ZS# +)0004 7+)+++- #ol) e^oZfblhe^$ +)40+4 G`WPS\RW[WRW\S #+).++/(,)+-4$ +)++-- #ol) mkb[^g]bfb]bg^$

- Kk^l^gm^] Zk^ ma^ f^Zg @> 0+ oZen^l pbma ma^ 40 >D Zg] = Zl p^ee Zl < oZen^l' _hk Z ]^m^kfbgZmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l) Nb`gb_b\Zgm ]b__^k^g\^ bg @> 0+ mh ]kn` bg [kZ\d^ml) < oZen^l p^k^ \hkk^\m^] _hk fnembie^ m^lmbg` nlbg` ma^ =hg_^kkhgb(Chef^l f^mah]) [ Oa^ 40 \hg_b]^g\^ bgm^koZe _hk Zfb]Zgm^e bl o^kr pb]^ Zg] ma^ =- jnbm^ ehp lbg\^ hger iZkmbZe bgab[bmbhg pZl h[mZbg^] Zm ab`a Zfb]Zgm^e \hg\^gmkZmbhgl)

,+, 1NGVZKX (

100 PF1022A 100 PF1022A+dAMD 90 Emodepside 90 PF1022A 80 80 dAMD 70 70 60 60 50 50 40 40 30 30 20 20 Paralysed larvae [%] 10 aParalysed larvae [%] 10 c 0 0 -6 -5 -4 -3 -2 -1 0 1 2 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [mg/ml] log 10 anthelmintic [µg/ml] 100 Tribenimidine 100 PF1022A+Tribendimidine 90 Amidantel 90 PF1022A 80 dAMD 80 Tribendimidine 70 70 60 60 50 50 40 40 30 30 20 20 Paralysed larvae [%] 10 b Paralysed larvae [%] 10 d 0 0 -6 -5 -4 -3 -2 -1 0 1 2 -6 -4 -2 0 2 log 10 anthelmintic [µg/ml] log 10 anthelmintic [µg/ml] 100 Tribendimidine+Levamisole 90 Tribendimidine 80 Levamisole 70 60 50 40 30 20 Paralysed larvae [%] 10 e 0 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml]

9WU& +%*& :# HXGYOROKTYOY fhmbebmr ZllZr ?ZmZ p^k^ ^qik^ll^] Zl bgab[bmbhg h_ ma^ gnf[^k h_ fhmbe^ eZkoZ^ bg ]kn`l Zg] \hgmkhel k^eZmbo^ mh ma^ f^Zg h_ ma^ o^ab\e^ \hgmkhel) ?hl^(k^lihgl^ \nko^l Zk^ lahpg _hk Z$ ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^6 [$ ma^ Zfbghia^greZfb]bg^ ]^kboZmbo^l mkb[^g]bfb]bg^' Zfb]Zgm^e Zg] ]

,+- 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

:# HXGYOROKTYOY GIKZ_RINUROTK KYZKXGYK YKIXKZOUT GYYG_ Oa^ ^__^\ml h_ Zfb]Zgm^e' ]a@ l^\k^mbhg [r Z]nem :# HXGYOROKTYOY Zk^ lahpg bg Ab`) .( . Zg] lnffZkbl^] bg OZ[) .( .) a@ l^\k^mbhg bg Z \hg\^gmkZmbhg(]^i^g]^gm fZgg^k) Dg `^g^kZe' fZqbfZe bgab[bmbhg bg ma^ Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZr pZl fn\a ehp^k maZg bg ma^ fhmbebmr ZllZrl) Dg \hgmkZlm mh ma^ k^lneml h_ [hma fhmbebmr ZllZrl' gh lb`gb_b\Zgm

]b__^k^g\^ bg @> 0+ oZen^l _hk ^fh]^ilb]^ Zg] KA,+--< pZl ]^m^\m^]) Nnkikblbg`er' fZqbfZe bgab[bmbhg h[l^ko^] _hk Zfb]Zgm^e pZl Z[hnm 01 ' pab\a pZl hger leb`amer ehp^k maZg fZqbfZe bgab[bmbhg _hk mkb[^g]bfb]bg^ #1. $) Oanl' Zfb]Zgm^e lahp^] ma^ lmkhg`^lm fZqbfZe ^__^\m hger bg ma^ ZllZr' pab\a k^o^Ze^] ma^ ehp^lm fZqbfZe ^__^\ml _hk Zee hma^k ]kn`l) 0+ oZen^ bl lb`gb_b\Zgmer ehp^k _hk ]

M^`Zk]bg` ]kn` \hf[bgZmbhgl' KA,+--< ienl mkb[^g]bfb]bg^ aZ] gh lb`gb_b\Zgmer ehp^k @>0+ oZen^ maZg mkb[^g]bfb]bg^ Zehg^ Zg] KA,+--< ienl ] 0+ oZen^ maZg e^oZfblhe^ Zehg^)

,+. 1NGVZKX (

GOP& +%+& >hfiZkblhg h_ m^lm^] ]kn`l Zg] ]kn`(\hf[bgZmbhgl bg ma^ :# HXGYOROKTYOY Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZr

O * 6][^]c\Ra 86 -( eWbV 1-% 6< M !U'[ZN % dOZcS &

8[]RS^aWRS +)+010+ +)0.+1 #ol) KA,+--<$ +)43/2 #+)+.420(+)+3+.,$ C9)(**4 +)+1331 +)0.+1 #ol) ^fh]^ilb]^$ +)4112 #+)+.4,/(+),-,,$ ?SdO[Wa]ZS +)-+4, +)411. #+),-4.(+)..3/$ 4[WRO\bSZ P 11)4, 7+)+++. #ol) ]

- Kk^l^gm^] Zk^ ma^ f^Zg @> 0+ oZen^l pbma ma^ 40 >D Zg] = Zl p^ee Zl < oZen^l' _hk Z ]^m^kfbgZmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l) Nb`gb_b\Zgm ]b__^k^g\^ bg @> 0+ mh ]kn` bg [kZ\d^ml) < oZen^l p^k^ \hkk^\m^] _hk fnembie^ m^lmbg` nlbg` ma^ =hg_^kkhgbÖChef^l f^mah]) [ Oa^ 40 \hg_b]^g\^ bgm^koZe _hk Zfb]Zgm^e bl o^kr pb]^ lbg\^ hger iZkmbZe bgab[bmbhg pZl h[mZbg^] Zm ab`a Zfb]Zgm^e \hg\^gmkZmbhgl)

,+/ 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

100 PF1022A 100 PF1022A+dAMD 90 Emodepside 90 PF1022A 80 80 dAMD 70 70 60 60 50 50 40 40 30 30 20 20 10 10 0 a 0 c Inhibition AChE activity [%] Inhibition AChE activity [%] -6 -5 -4 -3 -2 -1 0 1 2 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml] log 10 anthelmintic [µg/ml] 100 Tribendimidine 100 PF1022A+Tribendimidine 90 Amidantel 90 PF1022A 80 dAMD 80 Tribendimidine 70 70 60 60 50 50 40 40 30 30 20 20 10 10 0 c 0 d Inhibition AChE activity [%] Inhibition AChE activity [%] -6 -5 -4 -3 -2 -1 0 1 2 -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml] log 10 anthelmintic [µg/ml] 100 Levamisole+Tribendimidine 90 Levamisole 80 Tribendimidine 70 60 50 40 30 20 10 0 f Inhibition AChE activity [%] -6 -5 -4 -3 -2 -1 0 1 2 log 10 anthelmintic [µg/ml]

9WU& +%+& :# HXGYOROKTYOY Z\^mre\ahebg^ ^lm^kZl^ l^\k^mbhg ZllZr ?ZmZ p^k^ ^qik^ll^] Zl bgab[bmbhg h_ l^\k^m^] Z\^mre\ahebg^ ^lm^kZl^ bg ]kn`l Zg] \hgmkhel k^eZmbo^ mh ma^ f^Zg h_ ma^ o^ab\e^ \hgmkhel) ?hl^(k^lihgl^ \nko^l Zk^ lahpg _hk Z$ ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^6 [$ ma^ Zfbghia^greZfb]bg^ ]^kboZmbo^l mkb[^g]bfb]bg^' Zfb]Zgm^e Zg] ]

,+0 1NGVZKX (

+&- 7WaQcaaW]\

Oa^ k^\^gmer bg\k^Zl^] nmbeblZmbhg h_ H?< Z`Zbglm NOCl k^lnem^] bg lb`gb_b\Zgm k^]n\mbhgl h_ ik^oZe^g\^' bgm^glbmr h_ bg_^\mbhgl Zg] fhk[b]bmr) Chp^o^k' Zelh ehg`(m^kf lnlmZbgZ[bebmr h_ ma^ [^g^_bml h_ ma^ H?a@ l^\k^mbhg ZllZr' ^fh]^ilb]^ pZl lb`gb_b\Zgmer fhk^ ihm^gm maZg KA,+--<) Oa^l^ OT \OZXU k^lneml \hg_bkf Z gnf[^k h_ ik^obhnler in[ebla^] OT \O\U h[l^koZmbhgl lahpbg` maZm ^fh]^ilb]^ Zg] KA,+--< Zk^ ab`aer ^__^\mbo^ Z`Zbglm ]b__^k^gm lmZ`^l h_ :# HXGYOROKTYOY Zg] ?# YVOXGROY V,.' ..(.0W) Ra^k^Zl Z lbg`e^ hkZe mk^Zmf^gm h_ kZml pbma -)0 f`*d` ^fh]^ilb]^ k^lnem^] bg 944)+ ^__b\Z\r Z`Zbglm Z]nem phkfl bg ma^ bgm^lmbg^ V,.W' Z /+(_he] ab`a^k ]hlZ`^ h_ KA,+--< pZl g^\^llZkr mh Z\ab^o^ lbfbeZk k^lneml V..W)

Ra^ma^k ma^ ZiikhqbfZm^er -)/(_he] ]b__^k^g\^ bg @> 0+ oZen^l bg ma^ :# HXGYOROKTYOY fhmbebmr

ZllZr bl ln__b\b^gm mh ^qieZbg ma^ /+(_he] ]b__^k^g\^ bg ma^ G? 44 OT \O\U k^fZbgl ng\e^Zk) ?b__^k^g\^l bg ]kn` ^__b\Z\b^l [^mp^^g ]^o^ehif^gmZe lmZ`^l Zg] ]b__^k^g\^l bg [bhZoZbeZ[bebmr h_ ^fh]^ilb]^ \hfiZk^] mh KA,+--< bg ma^ ahlm [ehh] lrlm^f ik^lnfZ[er Zelh \hgmkb[nm^ mh ma^ ]b__^k^g\^l bg ihm^g\r OT \O\U V,.W) Dg \hfiZkblhg mh ma^ \r\ehh\mZ]^ilbi^imb]^l' ma^ ^__b\Z\r h_ ma^ Zfbghia^greZfb]bg^l pZl fhk^ a^m^kh`^g^hnl) Oa^ pb]^ kZg`^ h_ ]hlZ`^l k^ihkm^] mh [^ k^jnbk^] h_ Zfb]Zgm^e' ]

,+1 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY mkb[^g]bfb]bg^ pZl g^Zker Zl ihm^gm Zl ]hf[bgZmbhgl Zk^ Z[e^ mh ]^\^e^kZm^ ma^ ]^o^ehif^gm h_ ]kn` k^lblmZg\^ [nm Zelh mh bg\k^Zl^ ma^ li^\mknf Zg] ^__b\Z\r h_ ]kn`l) Nbg\^ \nk^ kZm^l h_ lbg`e^(mk^Zmf^gm k^`bf^gl nlbg` Ze[^g]Zshe^ Z`Zbglm anfZg ?# ZXOINO[XG bg_^\mbhgl p^k^ ln[lmZgmbZeer bg\k^Zl^] pa^g Ze[^g]Zshe^ ienl bo^kf^\mbg \hf[bgZmbhg p^k^ nl^] V/-W' bgo^lmb`Zmbhgl k^`Zk]bg` ]kn` \hf[bgZmbhgl mh mk^Zmf^gm NOCl p^k^ bgm^glb_b^] k^\^gmer V/.' //W) Oanl' \hf[bgZmbhgl h_ KA,+--< ienl ]aMl oZkb^l [^mp^^g ]b__^k^gm g^fZmh]^ li^\b^l' ]b__^k^gm l^ml h_ ln[ngbml fb`am ^qieZbg ]b__^k^gm l^glbmbobmb^l mh bg]bob]nZe \ahebg^k`b\ Zgma^efbgmb\l) Ahk bglmZg\^' 6# IUTZUXZ[Y G(<>aM(, bl ab`aer l^glbmbo^ mh e^oZfblhe^ [nm Zefhlm bgl^glbmbo^ mh irkZgm^e pa^k^Zl 6# IUTZUXZ[Y G(<>aM(- bl e^ll

,+2 1NGVZKX ( l^glbmbo^ mh e^oZfblhe^ [nm ab`aer k^lihglbo^ mh irkZgm^e V/0W) Ankma^kfhk^' bm aZl [^^g lahpg _hk /# IGTOT[S maZm ma^ ik^l^g\^ h_ ]b__^k^gm <>aM ln[ngbm ihineZmbhgl oZkb^l ]nkbg` ]b__^k^gm eb_^\r\e^ lmZ`^l' k^lnembg` bg ]b__^k^gm lnl\^imb[bebmb^l mh \ahebg^k`b\ ]kn`l V/1W) >hf[bgZmbhgl h_ e^oZfblhe^ ienl Z Zfbghia^greZfb]bg^ lahne] ma^k^_hk^ [^ bgo^lmb`Zm^] bg ma^ li^\b^l Zg] eb_^\r\e^ lmZ`^l h_ bgm^k^lm' gZf^er G.' G/ Zg] Z]nem phkfl h_ /# R[SHXOIUOJKY ' ?# ZXOINO[XG! :# GSKXOIGT[Y Zg] /# J[UJKTGRK Zl p^ee Zl bg ma^ k^li^\mbo^ ahlm li^\b^l mh ]kZp \hg\enlbhgl _hk Z ihm^gmbZe nl^ bg H?aMl k^lnembg` bg fnl\e^ \hgmkZ\mbhg V-/W' ma^ \r\ehh\mZ]^ilbi^imb]^l \Znl^ fnl\e^ k^eZqZmbhg obZ Z f^\aZgblf bgoheobg` NGJ(, ihmZllbnf \aZgg^el V,/W) Nbg\^ [hma ]kn`l aZo^ ^gmbk^er ]b__^k^gm fh]^l h_ Z\mbhg' Z]]bmbo^ ^__^\ml h_ ]kn`l _khf [hma ]kn` \eZll^l fb`am [^ ^qi^\m^]) Chp^o^k' ma^ _Z\m maZm ma^l^ ]kn` \eZll^l Z\m bg bg_en^g\^ fnl\e^ mhgnl bg hiihlbm^ ]bk^\mbhgl fb`am ik^o^gm Z]]bmbo^ ^__^\ml Zl h[l^ko^] bg Zee OT \OZXU ZllZrl bg mabl lmn]r) Oh \hg\en]^' ma^ m^lm^] \r\ehh\mZ]^ilbi^imb]^l Zg] Zfbghia^greZfb]bg^l Zee lahp^] Z ab`a ]^`k^^ h_ ^__b\Z\r Z`Zbglm Zee lmZ`^l Zg] li^\b^l Zg] l ahne] ma^k^_hk^ [^ ^oZenZm^] Zg] \hfiZk^] bg ma^ :# HXGYOROKTYOY OT \O\U fh]^e mh ikho^ b_ ma^ bgmkbglb\ ^__b\Z\r OT \OZXU bl Z `hh] fZkd^k _hk ma^ OT \O\U ^__b\Z\r bg mabl fh]^e) Oa^ lZf^ ]kn` \hf[bgZmbhgl lahne] [^ ^oZenZm^] bg ma^ lZf^ OT \O\U fh]^e mh ng^jnboh\Zeer ]^fhglmkZm^ ma^ Z[l^g\^ hk ik^l^g\^ h_ \hf[bgZmhkr ^__^\ml)

,+3 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

+&. 4QY\]eZSRUS[S\ba

Oa^ =Zr^k C^Zema>Zk^ Zk^

+&/ 6]\TZWQb ]T W\bS`Sab

<) CZk]^k Zg] ?) Fned^ p^k^ ^fiehr^^l h_ =Zr^k C^Zema>Zk^ Zk^ aZ] gh bg_en^g\^ hg ma^ ]^lb`g h_ ma^ lmn]r)

,+4 1NGVZKX (

+&0 ESTS`S\QSa

,) Gnlmb`fZg N' Kkb\aZk] MF' BZssbg^eeb <' BkZgm RI' =hZmbg =<' H\>Zkmar EN' =ZlZg^s HB' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 ma^ ikh[e^f h_ a^efbgmabZl^l) KGhN I^`e Okhi ?bl 1' ^,03-) -) >khfimhg ?RO' Rhke] C^Zema Jk`ZgbsZmbhg' -++1' Kk^o^gmbo^ \a^fhma^kZir bg anfZg a^efbgmabZlbl5 \hhk]bgZm^] nl^ h_ Zgma^efbgmab\ ]kn`l bg \hgmkhe bgm^ko^gmbhgl5 Z fZgnZe _hk a^Zema ikh_^llbhgZel Zg] ikh`kZff^ fZgZ`^kl) Rhke] C^Zema Jk`ZgbsZmbhg' B^g^oZ) .) >khfimhg ?RO' NZobheb G' -++2' CZg][hhd h_ a^efbgmabZlbl _hk in[eb\ a^Zema) >M>*OZrehk ! AkZg\bl' =h\Z MZmhg) /) R^Zo^k CE' CZp]hg EH' Ch[^k` @K' -+,+' Nhbe(mkZglfbmm^] a^efbgmabZl^l5 bfieb\Zmbhgl h_ \ebfZm^ \aZg`^ Zg] anfZg [^aZobhk) Ok^g]l KZkZlbmhe -1' 02/(03,) 0) Kkb\aZk] MF' =ZlZg^s HB' =hZmbg =<' H\>Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 1' ^,0/4) 1) Rhelm^gahef^ ' -++/' ?kn` k^lblmZg\^ bg o^m^kbgZkr a^efbgmal) Ok^g]l KZkZlbmhe -+' /14(/21) 2) Rhke] C^Zema Jk`ZgbsZmbhg' -+,,' RCJ fh]^e eblm h_ ^ll^gmbZe f^]b\bg^l 5 ,2ma eblm' HZk\a -+,,) Rhke] C^Zema Jk`ZgbsZmbhg' B^g^oZ) 3) Rhke] C^Zema Jk`ZgbsZmbhg' -+,,' RCJ fh]^e eblm h_ ^ll^gmbZe f^]b\bg^l _hk \abe]k^g5 .k] eblm' HZk\a -+,,) Rhke] C^Zema Jk`ZgbsZmbhg' B^g^oZ) 4) JeebZkh K' N^be^k E' Fn^l^e <' Chkmhg E' >eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) ,+) CZk]^k <' N\afbmm(Rk^]^ CK' Fk{\d^g E' HZkbgholdb K' Rng]^keb\a A' Rbeelhg E' r\ehh\mZ]^ilbi^imb]^l((Zg Zgma^efbgmb\Zeer Z\mbo^ \eZll h_ \hfihng]l ^qab[bmbg` Z gho^e fh]^ h_ Z\mbhg) Dgm E ?' -+,,' Kkh`k^ll Zg] \aZee^g`^l bg ma^ ]bl\ho^kr h_ fZ\kh_beZkb\b]Ze ]kn`l) @qi^km M^o

,,+ 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

,.) CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++-' >r\ehh\mZ]^ilbi^imb]^l ( Z g^p \eZll h_ Zgma^efbgmb\Zeer Z\mbo^ \hfihng]l) KZkZlbmhe M^l 33' /3,(/33) ,/) Fk{\d^g E' CZk]^k <' E^l\ad^ K' Che]^g(?r^ G' J">hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' hgghk Q' CZk]^k <' Che]^g(?r^ G' Chii^k I<' -++2' Oa^ \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e' NGJ(,' bl k^jnbk^] _hk ma^ Z\mbhg h_ ma^ gho^e \r\eh(h\mZ]^ilbi^imb]^ Zgma^efbgmb\' ^fh]^ilb]^' bg 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' ,022(,033) ,1) R^es >' Fk{`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fk{\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+) ,2) SbZh NC' Cnb(Hbg` R' OZgg^k H' Pmsbg`^k E' >ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) ,3) Rheep^[^k C' Ib^f^kl @' Aen\d^ R' ' ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' -+,-' 7T \O\U ^__b\Z\r h_ ma^ Zgma^efbgmb\ mkb[^g]bfb]bg^ Z`Zbglm ma^ \^lmh]^ 6_SKTURKVOY SOIXUYZUSG bg Z \hgmkhee^] eZ[hkZmhkr mkbZe) <\mZ Okhi ,-.' 23(3/) -+) Nm^bgfZgg K' Uahn SI' ?n UR' EbZg` ET' SbZh NC' Rn US' Uahn C' Pmsbg`^k E' -++3' Okb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ _hk mk^Zmbg` lhbe(mkZglfbmm^] a^efbgmal' >ZXUTM_RUOJKY YZKXIUXGROY Zg] ?GKTOG lii)5 hi^g(eZ[^e kZg]hfbs^] mkbZe) KGhN I^`e Okhi ?bl -' ^.--) -,) TnZg B' Sn E' Ln O' RZg` =' UaZg` M' R^b >' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l M ? ,+' 3.(4+) --) Ohfebglhg B' <' Rhh]l M< #,430$ Oa^ ^__^\ml h_ Zfb]Zgm^e #=

,,, 1NGVZKX (

-.) Okbmm^g G' Iphln P' QZk`Zl H' F^bl^k E' -+,-' 7T \OZXU Zg] OT \O\U ^__b\Z\r h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Zehg^ Zg] bg \hf[bgZmbhg Z`Zbglm ma^ ahhdphkfl 6KROMSUYUSUOJKY HGQKXO Zg] /TI_RUYZUSG IK_RGTOI[S ) <\mZ Okhi ,--' ,+,(,+2) -/) Cn T' SbZh NC' ' N\agbms^kebg` CE' IheZg E' F^bma MF' ,42.' <\^mre\ahebg^lm^kZl^ l^\k^mbhg [r iZkZlbmb\ g^fZmh]^l) D) @ob]^g\^ _hk l^\k^mbhg h_ ma^ ^gsrf^ [r Z gnf[^k h_ li^\b^l) Dgm E KZkZlbmhe .' 034(042) -2) Mhmap^ee OG' J`beob^ =H' Gho^ ME' ,42.' <\^mre\ahebg^lm^kZl^ l^\k^mbhg [r iZkZlbmb\ g^fZmh]^l) DD) ?XOINUYZXUTM_R[Y lii) Dgm E KZkZlbmhe .' 044(1+3) -3) RZmml N?' MZilhg @=' aZg`^l bg ma^ Z\^mre\ahebg^lm^kZl^ Z\mbobmr h_ ma^ g^fZmh]^ :OVVUYZXUTM_R[Y HXGYOROKTYOY _heehpbg` mk^Zmf^gm pbma [^gsbfb]Zshe^l OT \O\U ) Hhe =bh\a^f KZkZlbmhe /' 4(,0) .+) @eefZg BG' >hnkmg^r F?' hg]^k B<' Ehaglhg NN' IhpZdhpldb ?N' =eZd^ O@' ?nmmhg A@' I^elhg NE' OahfZl @H' ?Zobl EK' Oahfilhg ?K' ,440'

,,- 7T \OZXU KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY

.0) RZg` H' RZmZgZ[^ I' NahfnkZ O' Jamhfh C' ,440' @__^\ml h_ KA,+--< hg :OVVUYZXUTM_R[Y HXGYOROKTYOY bg kZml Zg] 6_SKTURKVOY TGTG bg fb\^) Eig E KZkZlbmhe //' .+1(.,+) .1) Gb MC' BZh EC' RZg` NA' K^b TE' Na^g ET' TZg KH' Tbg BM' -+,,' @__^\m h_ hkZe Z]fbgblmkZmbhg h_ mkb[^g]bfb]bg^ Zm ]b__^k^gm ]hlZ`^l Z`Zbglm ?XOINOTKRRG YVOXGROY ^g\ZilneZm^] eZkoZ^ bg fb\^) >abg E KZkZlbmhe KZkZlbm ?bl -4' ,,2(,-,) .2) Sn^ E' SbZh NC' Sn GG' LbZg` CL' -+,+' Oa^ ^__^\m h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Z`Zbglm :KIGZUX GSKXOIGT[Y bg `he]^g aZflm^kl Zg] :OVVUYZXUTM_R[Y HXG`OROKTYOY bg kZml) KZkZlbmhe M^l ,+1' 220(23,) .3) Sn^ E' SbZh NC' Sn GG' UaZg` TI' LbZg` CL' -+,+' @__b\Z\r h_ mkb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ bg mk^Zmbg` fb\^ bg_^\m^] pbma ?XOINOTKRRG YVOXGROY ) >abg E KZkZlbmhe KZkZlbm ?bl -3' 3(,,) .4) Rhh]l M<' HZehg^ FH=' ,430' Oa^ ^__^\ml h_ Zfb]Zgm^e #=Zg E Uhhe 1/' ,.,+(,.,1) /+) Bneb\d MH' H^eehkl ER' CZoebk ?' @khg EE' BhgsZe^s >' H\HZahg ?' Mb\afZg ??' QZe^gmbg^ AO' EhgZl G' H^b[haf <' @fbgb @<' >ah]Zd^pbms E<' ?^nml\a K' Che]^k ?' N\ae^b_ R<' >hg]kZ EC' ,442' Ok^Zmf^gm pbma bg]bgZobk' sb]hon]bg^' Zg] eZfbon]bg^ bg Z]neml pbma anfZg bffngh]^_b\b^g\r obknl bg_^\mbhg Zg] ikbhk Zgmbk^mkhobkZe ma^kZir) I @g`e E H^] ..2' 2./(2.4) /,) G^Zmapb\d ?H' Chldbg` =>' =bll^m N<' H\FZr >C' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 bl bm _^Zlb[e^ bg I^p U^ZeZg] mh ]^eZr ma^ ^f^k`^g\^ h_ k^lblmZg\^ mh Z g^p Zgma^efbgmb\ \eZll: I^p U^Ze Q^m E 02' ,3,(,4-) /-) Jel^g <' -++2' @__b\Z\r Zg] lZ_^mr h_ ]kn` \hf[bgZmbhgl bg ma^ mk^Zmf^gm h_ l\ablmhlhfbZlbl' lhbe(mkZglfbmm^] a^efbgmabZlbl' erfiaZmb\ _beZkbZlbl Zg] hg\ah\^k\bZlbl) O Mhr Nh\ Okhi H^] C ,+,' 2/2(203) /.) Fghii N' HhaZff^] F<' Ni^b\a =' CZmm^g]hk_ E' FaZfbl DN' FaZfbl ebg Dg_^\m ?bl 0,' ,/-+(,/-3) //) Ni^b\a ='

,,. 1NGVZKX (

/0) HZkmbg ME' Mh[^kmlhg aZko^m >G' I^o^n >' -+,-' G^oZfblhe^ k^\^imhkl5 Z l^\hg] ZpZd^gbg`) Ok^g]l KZkZlbmhe -3' -34(-41) /1) Fhms^ <>' Ghp^ <' J"BkZ]r E' Fhii NM' =^agd^ EH' -++4' ?hl^(k^lihgl^ ZllZr m^fieZm^l _hk OT \OZXU Zll^llf^gm h_ k^lblmZg\^ mh [^gsbfb]Zshe^ Zg] gb\hmbgb\ Z\^mre\ahebg^ k^\^imhk Z`hgblm ]kn`l bg anfZg ahhdphkfl)

,,/ Chapter 4

In vivo efficacy of PF1022A and nicotinic receptor agonists alone and in combination against Nippostrongylus brasiliensis

Kulke D., Krücken J., Harder A., Krebber R., Fraatz C., Mehlhorn H., von Samson- Himmelstjerna G.

Parasitology 2013, 140 (10): 1252-1265.

http://dx.doi.org/10.1017/S0031182013000632 1NGVZKX )

, "2 9/93 STTWQOQg ]T C9)(**4 O\R \WQ]bW\WQ OQSbgZQV]ZW\S `SQS^b]` OU]\Waba OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab #/44367532-:086 *5)6/0/,26/6

,&) 4Pab`OQb

Oa^ \r\ehh\mZ]^ilbi^imb]^ KA,+--< Zg] ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]hf[bgZmbhgl h_ mkb[^g]bfb]bg^ Zg] ]hf[bgbg` ma^l^ pbma k^`blm^k^] ]kn`l fZr a^ei mh ik^o^gm ]^o^ehif^gm h_ k^lblmZg\^)

,,1 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,&* <\b`]RcQbW]\

Dg ab`aer ^g]^fb\ \hngmkb^l' ma^ eZk`^lm iZkm h_ fhk[b]bmr(\hgmkhe k^`Zk]bg` NOCl k^eb^l hg \a^fhma^kZir nlbg` Zgma^efbgmb\l bg H?r\ehh\mZ]^ilbi^imb]^l l^^f mh [^ Zg bgm^k^lmbg` \eZll _hk ma^ ]^o^ehif^gm h_ ]kn`l mh mk^Zm anfZg NOCl' lbg\^ ma^r lahp Z ab`a ]^`k^^ h_ g^fZmb\b]Ze ^__b\Z\r bg Z [khZ] kZg`^ h_ ahlml V2'3W) Oa^ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^' Zg ^ll^gmbZe \hfihg^gm h_ ma^ k^\^gmer k^`blm^k^] o^m^kbgZkr ikh]n\ml Kkh_^g]^k Ä #=Zr^k abgZ V3',-W) Dg ma^ eZm^ ,42+l ma^ Zfbghia^greZfb]bg^ Zfb]Zgm^e pZl k^ihkm^] mh [^ ^__b\Z\bhnl Z`Zbglm l^o^kZe g^fZmh]^l Zg] ieZmra^efbgmal V,.W) Rabe^ lmn]rbg` Zfbghia^greZfb]bg^ lmkn\mnk^( Z\mbobmr k^eZmbhglabi' mkb[^g]bfb]bg^ pZl ]^o^ehi^] bg ,43. V,-W) M^jnbkbg` ehp^k ]hlZ`^l maZg Zfb]Zgm^e' mkb[^g]bfb]bg^ aZl Z [khZ] li^\mknf h_ Zgma^efbgmb\ ^__b\Z\r bg Z oZkb^mr h_ ahlml' bg\en]bg` anfZgl V,-W) Oa^ fZchk f^mZ[hebm^ h_ Zfb]Zgm^e Zg] mkb[^g]bfb]bg^ bl ]

,,2 1NGVZKX )

ZiiZk^gmer ghm bg \^lmh]^l Ö Zm e^Zlm ghm bg 6# SOIXUYZUSG V,1W) Dg 1# KRKMGTY ' ma^ fh]^ h_ Z\mbhg h_ mkb[^g]bfb]bg^ bl o^kr lbfbeZk mh maZm h_ e^oZfblhe^ lbg\^ [hma ]kn`l Z\m Zl Z`hgblml makhn`a Zm e^Zlm o^kr lbfbeZk g<>aMl V,2W) ?^libm^ lbfbeZk mZk`^ml' lrg^k`blmb\ ^__^\ml h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ Z`Zbglm /# IK_RGTOI[S OT \OZXU Zg] OT \O\U Zg] ZgmZ`hgblmb\ ^__^\ml Z`Zbglm 6# HGQKXO OT \OZXU Zg] OT \O\U V,0W aZo^ [^^g k^ihkm^] k^\^gmer) R^ Zelh h[l^ko^] ZgmZ`hgblmb\ ^__^\ml h_ [hma ]kn` \eZll^l Z`Zbglm :# HXGYOROKTYOY Zg] ?# YVOXGROY OT \OZXU V,3W) Nbg\^ ma^ \r\ehh\mZ]^ilbi^imb]^l Zg] Zfbghia^greZfb]bg^l lahp^] Z lb`gb_b\Zgm OT \OZXU ^__b\Z\r Z`Zbglm G. Zg] Z]nem phkfl h_ :# HXGYOROKTYOY V,3W' ma^ ik^l^gm lmn]r Zbf^] mh ^oZenZm^ Zg] \hfiZk^ ma^ OT \O\U ihm^g\r h_ [hma ]kn` \eZll^l bg ma^ :# HXGYOROKTYOY fh]^e) Oa^ ^__b\Z\r h_ \hf[bgZmbhgl h_ \r\ehh\mZ]^ilbi^imb]^l pbma Zfbghia^greZfb]bg^l aZl ghm [^^g bgo^lmb`Zm^] OT \O\U ikbhk mh mabl lmn]r) Rabe^ ma^ ^__^\ml h_ e^oZfblhe^*mkb[^g]bfb]bg^ \hf[bgZmbhgl p^k^ o^kr a^m^kh`^g^hnl pa^g \hfiZkbg` ]b__^k^gm g^fZmh]^ li^\b^l V,0W' ]kn` \hf[bgZmbhgl h_ KA,+--< Zg] ]

,,3 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,&+ @ObS`WOZa O\R [SbV]Ra

3ZNOIGR YZGZKSKTZ Zk^

2X[MY Zk^ M Bf[C ! >h) FB #FZkelkna^' B^kfZgr$ Zg] mkb[^g]bfb]bg^ pZl h[mZbg^] _khf NaZg]hg` SbganZ KaZkfZ\^nmb\Ze >hfiZgr Gbfbm^] #Ub[h' K^hie^"l M^in[eb\ h_ >abgZ$) ngmbe _nkma^k nl^) ?kn`l p^k^ ZepZrl _k^laer ik^iZk^] Zl ]bli^klbhgl bg >k^fhiahk @G #=

/TOSGRY A^fZe^ eZ[hkZmhkr hnm[k^] RblmZk kZml #Cl]>i[5RP$ p^k^ ink\aZl^] _khf CZkeZg I^ma^keZg]l Zm Zg Z`^ h_ 1(,+ p^^dl pbma Z [h]r p^b`am h_ ,-0(,20 `) MZml p^k^ ahnl^] bg HZ\khehg Ä \Z`^l ng]^k ^gobkhgf^gmZeer \hgmkhee^] \hg]bmbhgl Zg] d^im bg `khnil h_ .(0 ZgbfZel) RZm^k Zg] Ngb__ Ä kh]^gm _hh] i^ee^ml p^k^ ZoZbeZ[e^ Z] eb[bmnf) MZml p^k^ Zeehp^] mh Z\\ebfZm^ _hk l^o^g ]Zrl [^_hk^ lmZkmbg` Zgr ^qi^kbf^gm)

e' /)2 fH F>e'

-)0- fH >Z>e -' ,),3 fH H`NJ /' ,),3 fH FC -KJ /' -0)+, fH IZC>J .' iC 2)/$ \hgmZbgbg` khnmbg^er -0++ bg_^\mbo^ G.) Jg ]Zr lbq V#O)' _Z^\^l p^k^ \hee^\m^]' fbq^] pbma \aZk\hZe Zg] \aZk\hZe(_bem^k^] pZm^k Zg] bg\n[Zm^] Zm .2 |> Zg] 40 k^eZmbo^ anfb]bmr _hk _bo^ ]Zrl) GZkoZ^ p^k^ \hee^\m^] Zg] bg\n[Zm^] _hk Zghma^k mph ]Zrl Zm khhf m^fi^kZmnk^ mh ^glnk^ \hfie^m^ ]^o^ehif^gm mh bg_^\mbo^ G.) GZkoZ^ p^k^ pZla^] Zg] ma^g nl^] _hk bg_^\mbhg h_ kZml)

,,4 1NGVZKX )

7T \O\U KLLOIGI_ UL JX[MY GMGOTYZ :# HXGYOROKTYOY OT XGZY Dg Z l^kb^l h_ -/ \hgl^\nmbo^ ^qi^kbf^gml #[eh\dl$' Z mhmZe h_ 0++ kZml p^k^ kZg]hfbl^] bgmh ,++ `khnil' ^Z\a \hglblmbg` h_ _bo^ ZgbfZel) Oa^ kZml p^k^ bg_^\m^] hkZeer pbma Z `ZoZ`^ nlbg` +)0 fe iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg \hgmZbgbg` bg_^\mbo^ G. h_ :# HXGYOROKTYOY ) Dg bgbmbZe ^qi^kbf^gml' ]b__^k^gm bg_^\mbhg ]hl^l kZg`bg` [^mp^^g ZiikhqbfZm^er 1++ Zg] 0+++ G. p^k^ nl^] mh ZgZerl^ ma^ k^eZmbhglabi [^mp^^g ma^ bg_^\mbo^ ]hl^ Zg] k^\ho^k^] Z]nem phkfl) Rbmabg ^Z\a [eh\d Zee ZgbfZel k^\^bo^] ma^ lZf^ gnf[^k h_ G.) Ahk ^Z\a ]hl^ h_ Z ]kn` Zm e^Zlm _bo^ kZml p^k^ nl^]) Dg ^Z\a [eh\d' _bo^ o^ab\e^(mk^Zm^] kZml p^k^ nl^] Zl bg_^\mbhg \hgmkhel) Oh Z\ab^o^ ^qZ\mer ma^ ]^lbk^] ]kn` ]hlZ`^l' Zfhngml h_ ]kn`l p^k^ \Ze\neZm^] _hk bg]bob]nZe ZgbfZel ]^i^g]bg` hg [h]r p^b`aml ]^m^kfbg^] hg ]Zr . V#O# Jg ]Zrl /(1 V#O)' kZml p^k^ hkZeer mk^Zm^] pbma ]kn`l bg >k^fhiahk @G*pZm^k ]bli^klbhgl) ?hlZ`^l h_ 0+' 20' ,++' ,-0' -++' -0+' Zg] 0++ f`*d` Zfb]Zgm^e' ,)+' -)0' .)20' /)-0' 0)+' ,+' -0' 0+' ,++' Zg] -0+ f`*d` ]k^fhiahk @G*pZm^k) <]]bmbhgZeer' mp^eo^ \hf[bgZmbhgl p^k^ Z]fbgblm^k^] #OZ[) /( ,$) Jg ]Zr 2 V#O#! kZml p^k^ ^nmaZgbl^] [r \Zk[hg ]bhqb]^ ln__h\Zmbhg) Nn[l^jn^gmer' g^\khilr pZl i^k_hkf^] Zg] phkf [nk]^g bg ma^ ]nh]^gnf pZl ]^m^kfbg^] [r \hngmbg` ma^ iZkZlbm^l ng]^k Z ]bll^\mbg` fb\khl\hi^)

GOP& ,%)& ?hl^l h_ ]kn` \hf[bgZmbhgl Z]fbgblm^k^] bg ma^ :# HXGYOROKTYOY OT \O\U ZllZr

G`WPS\RW[WRW\S R4@7 #f`*d`$ #f`*d`$ C9)(**4 ,)+*-)0 ,)+*-)0 #f`*d`$ ,)0*-)0 ,)0*-)0 ,)0*.)20 ,)0*.)20 ?SdO[Wa]ZS -)0*-)0 -)0*-)0 #f`*d`$ 0)+*-)0 0)+*-)0 ?kn` bg khp ho^k ]kn`0)+*.)20 bg \henfg 0)+*.)20

9UXVNURUMOIGR OT\KYZOMGZOUT UL GJ[RZ :# HXGYOROKTYOY GLZKX JX[M K^VUY[XK

Ahk ]^m^kfbgZmbhg h_ ]kn` ^__^\ml hg iZkZlbm^ fhkiaheh`r' ln[himbfZe ]hlZ`^l h_ ,++ f`*d` Zfb]Zgm^e' -)0 f`*d` ]

,-+ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

KA,+--< ienl -)0 f`*d` mkb[^g]bfb]bg^ Zg] -)0 f`*d` e^oZfblhe^ ienl -)0 f`*d` mkb[^g]bfb]bg^ p^k^ nl^]) Oa^ g^`Zmbo^ \hgmkhe `khni k^\^bo^] hger ma^ o^ab\e^ #>k^fhiahk @G*pZm^k$) < mhmZe h_ -2 kZml p^k^ kZg]hfbl^] bgmh gbg^ `khnil' \hglblmbg` h_ mak^^ kZml ^Z\a) Jma^kpbl^' ma^ bg_^\mbhg( Zg] mk^Zmf^gm(ikhmh\he pZl b]^gmb\Ze mh maZm nl^] _hk ]kn` ^__b\Z\r mkbZel) Dff^]bZm^er Z_m^k g^\khilr Zg] k^l^\mbhg h_ ma^ `nml' lfZee bgm^lmbg^l p^k^ hi^g^] ehg`bmn]bgZeer Zg] phkfl bg ma^ bgm^lmbgZe fn\hlZ p^k^ \Zk^_neer blheZm^] nlbg` _bg^ lnk`b\Ze _hk\^il) Ahk ^Z\a mk^Zmf^gm `khni' phkfl p^k^ \hee^\m^] Zg] ik^_bq^] bg lgZi(\Zi obZel \hgmZbgbg` 0 `enmZkZe]^ar]^ #N@MQ< @e^\mkhiahk^lbl Bf[C' C^b]^e[^k`' B^kfZgr$ bg +), H \Z\h]reZm^ [n__^k #iC 2).$ Zm / |> ho^kgb`am) Oa^g' phkfl p^k^ pZla^] lbq mbf^l nlbg` +), H \Z\h]reZm^ [n__^k' _heehp^] [r ]^ar]kZmbhg h_ ma^ lZfie^l nlbg` Zg Zl\^g]bg` ^maZghe l^kb^l) Rhkfl p^k^ bg\n[Zm^] bg 2+ ' 3+ ' 4+ ' 41 ' Zg] ,++ ^maZghe _hk ,0 fbg ^Z\a _heehp^] [r bg\n[Zmbhg bg _k^la ,++ ^maZghe Zm / |> _hk -/ a) >kbmb\Ze ihbgm ]krbg` pZl i^k_hkf^] pbma ma^ >K? +.+ >kbmb\Ze Khbgm ?kr^k #= Bf[C' N\aZedlf{ae^' B^kfZgr$ Zg] \Zk[hg ]bhqb]^ Zl mkZglbmbhg _enb]) ?kb^] lZfie^l p^k^ `he](linmm^k^] _hk - fbg Zm ,0 f< nlbg` ma^ linmm^k \hZm^k @fbm^\a F00+ #@fbm^\a Gm])' Zke U^bll NHO

,-, 1NGVZKX )

>hg\^gmkZmbhgl h_ ]hki)' HhngmZbg Qb^p' PN<$) Ihg(\hfiZkmf^gmZe ZgZerlbl h_ ^qmkZoZl\neZk ]hlbg` Zg] liZkl^ lZfiebg` pZl nl^] mh ]^kbo^ ma^ iaZkfZ\hdbg^mb\ ikh_be^l h_ ]

1GRI[RGZOUT UL JUYK"XKYVUTYK I[X\KY GTJ YZGZOYZOIGR GTGR_YOY Ahk lbg`e^ ]kn` mk^Zmf^gml' k^]n\mbhg h_ phkf [nk]^g bg \hfiZkblhg mh ma^ f^Zg phkf [nk]^g h_ ma^ k^li^\mbo^ ieZ\^[h(mk^Zm^] \hgmkhe #^qik^ll^] bg i^k \^gm$ pZl iehmm^] Z`Zbglm ma^ eh` ,+ h_ ma^ ]kn` ]hlZ`^l) Oa^g' _hnk(iZkZf^m^k(eh`blmb\ \nko^l p^k^ _bm nlbg` BkZiaKZ]

Kkblf 0)+.) @? 0+ oZen^l p^k^ \hfiZk^] nlbg` ma^ ^qmkZ lnf h_ ljnZk^l 4 m^lm) Dg \Zl^l pa^k^ fnembie^ m^lml p^k^ i^k_hkf^]' < oZen^l p^k^ \hkk^\m^] nlbg` ma^ =hg_^kkhgb(Chef^l ikh\^]nk^) Oa^ \hf[bgZmbhgl p^k^ \hfiZk^] mh k^li^\mbo^ lbg`e^ ]kn` mk^Zmf^gml nlbg` ma^ ghg( iZkZf^mkb\ FknldZe(RZeebl m^lm pbma ?nggâl ihlm ah\ m^lm _hk b]^gmb_b\Zmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g bg]bob]nZe `khnil) Dg hk]^k mh b]^gmb_r Zgr Z]]bmbo^ hk lrg^k`blmb\ ]kn` ^__^\ml' ^__b\Z\r h_ ma^ \hf[bgZmbhgl pZl \hfiZk^] bg Z Rbe\hqhg lb`g^] kZgd(lnf m^lm mh Z ma^hk^mb\Ze ^qi^\m^] f^]bZg' pab\a pZl l^m mh ma^ lnf h_ ma^ f^]bZg ^__b\Z\b^l h_ ma^ bg]bob]nZe ]kn`l) Oa^l^ \Ze\neZmbhgl p^k^ Zelh i^k_hkf^] nlbg` BkZiaKZ] Kkblf lh_mpZk^ o^klbhg 0)+.)

,-- 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,&, ESacZba

=KVXUJ[IOHOROZ_ UL ]UXS XKIU\KX_ LUX JOLLKXKTZ OTLKIZO\K JUYKY Nbg\^ ma^ -/ gh(]kn` \hgmkhe `khnil #^Z\a \hglblmbg` h_ _bo^ ZgbfZel$ oZkb^] bg ma^ bg_^\mbo^ ]hl^l #1++(0+++ eZkoZ^ i^k kZm$' ik^ebfbgZkr lmZmblmb\Ze ZgZerl^l p^k^ i^k_hkf^]) < ihlbmbo^ \hkk^eZmbhg [^mp^^g ma^ Z[lhenm^ gnf[^k h_ eZkoZ^ nl^] _hk ma^ hkZe bg_^\mbhg Zg] ma^ Z[lhenm^ gnf[^k h_ Z]nem phkfl k^\ho^k^] _khf ma^ lfZee bgm^lmbg^l Z_m^k g^\khilr pZl b]^gmb_b^] [r ebg^Zk k^`k^llbhg #Ab`) /( ,<$) Oa^k^ pZl Z lb`gb_b\Zgm ihlbmbo^ \hkk^eZmbhg [^mp^^g ma^ gnf[^k h_ Z]nem phkfl k^\ho^k^] _khf ma^ bgm^lmbg^l Zg] ma^ bg_^\mbo^ ]hl^ # <7+)+++,$) Oa^ lehi^ h_ ma^ k^`k^llbhg \nko^ pZl +).+42 É +)+,3/4 Zg] ma^ \h^__b\b^gm h_ ]^m^kfbgZmbhg pZl ='8+)2+01) >hfiZkblhg h_ \hgmkhe `khnil _khf ^b`am bg]^i^g]^gm ^qi^kbf^gml pbma Z \hglblm^gm bg_^\mbo^ ]hl^ h_ -+++ eZkoZ^ k^o^Ze^] \hglb]^kZ[e^ oZkbZmbhg bg k^\ho^kr kZm^l #Zl Z i^k\^gmZ`^ h_ ma^ bg_^\mbo^ ]hl^$ [^mp^^g bg]bob]nZe kZml [nm gh lb`gb_b\Zgm ]b__^k^g\^l bg ma^ k^\ho^kr kZm^l h_ Z]nem phkfl [^mp^^g ^qi^kbf^gml #Ab`) /( ,=$) Ra^g k^\ho^kr kZm^l [^mp^^g ]b__^k^gm bg_^\mbo^ ]hl^l p^k^ \hfiZk^] nlbg` Z FknldZe(RZeebl _heehp^] [r Z ?nggâl ihlm ah\ m^lm' ma^ ehp^lm ]hl^ h_ 1++ eZkoZ^ Zg] ma^ mph ab`a^lm ]hl^l h_ .+++ Zg] 0+++ eZkoZ^ k^lnem^] bg lb`gb_b\Zgmer ehp^k hk ab`a^k phkf k^\ho^kr kZm^l' k^li^\mbo^er #Ab`) /( ,>$) Ih lb`gb_b\Zgm ]b__^k^g\^ bg ma^ k^eZmbo^ k^\ho^kr kZm^ h_ Z]nem phkfl pZl b]^gmb_b^] [^mp^^g Zgr h_ ma^ bg_^\mbo^ ]hl^l [^mp^^g ,+++ Zg] -0++ eZkoZ^ #Ab`) /( ,>$) Oa^k^_hk^' hger ^qi^kbf^gml pbma Zg bg_^\mbo^ ]hl^ [^mp^^g ,+++ Zg] -0++ eZkoZ^ p^k^ bg\en]^] bg ma^ ZgZerl^l h_ ma^ OT \O\U ^__b\Z\r h_ ma^ m^lm \hfihng]l Z`Zbglm :# HXGYOROKTYOY #g8/++ kZml$)

,-. 1NGVZKX )

9WU& ,%)& M^ikh]n\b[bebmr h_ phkf k^\ho^kr bg ieZ\^[h(mk^Zm^] kZml <$ Plbg` bg_^\mbo^ ]hl^l [^mp^^g 1++ Zg] 0+++ :# HXGYOROKTYOY G.' k^\ho^kr h_ Z]nem phkfl lahp^] lb`gb_b\Zgm \hkk^eZmbhg [^mp^^g bg_^\mbo^ ]hl^ Zg] phkf [nk]^g # <7+)+++,$) =$ Ra^g k^\ho^kr pZl \Ze\neZm^] bg i^k\^gmZ`^ h_ ma^ bg_^\mbo^ ]hl^' \hfiZkblhg [^mp^^g ^b`am ^qi^kbf^gml pbma kZml bg_^\m^] pbma -+++ eZkoZ^ k^o^Ze^] ab`a oZkbZ[bebmr [^mp^^g bg]bob]nZe ZgbfZel [nm gh lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g ^qi^kbf^gml Zl ]^m^kfbg^] bg Z FknldZe(RZeebl m^lm) >$ Nb`gb_b\Zgm ]b__^k^g\^l bg k^\ho^kr kZm^l p^k^ h[l^ko^] [^mp^^g ^qi^kbf^gmZe `khnil bg_^\m^] pbma ]b__^k^gm gnf[^kl h_ eZkoZ^) Chp^o^k' pa^g k^\ho^kr kZm^l p^k^ \hfiZk^] [^mp^^g bg_^\mbo^ ]hl^l kZg`bg` _khf ,+++ mh -0++ eZkoZ^' gh lb`gb_b\Zgm ]b__^k^g\^l p^k^ ]^m^\mZ[e^)

,-/ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

7T \O\U KLLOIGI_ UL JX[MY GMGOTYZ :# HXGYOROKTYOY OT XGZY G^oZfblhe^' KA,+--< Zg] ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]D Zg] = oZen^l) Ankma^kfhk^' <(oZen^l _hk

\hfiZkblhgl [^mp^^g @? 0+ oZen^l h_ ]b__^k^gm Zfbghia^greZfb]bg^l Zk^ bg]b\Zm^] #OZ[) /( -$) ?n^ mh ma^ eZk`^ oZkbZ[bebmr bg phkf k^\ho^kr [^mp^^g bg]bob]nZe kZml Zl ]^l\kb[^] Z[ho^' =' _hk ma^l^ OT \O\U ]hl^(k^lihgl^ \nko^l Zk^ k^eZmbo^er ehp #+)/0(+)32$)

Oa^ @? 0+ oZen^ _hk Zfb]Zgm^e pZl ZiikhqbfZm^er .+ mbf^l ab`a^k maZg ma^ @? 0+ oZen^l h_ ma^ hma^k Zfbghia^greZfb]bg^ ]^kboZmbo^l ]

:# HXGYOROKTYOY ) Oa^ @? 0+ oZen^ _hk KA,+--< #,)- f`*d`$ pZl ZiikhqbfZm^er mak^^ mh _hnk mbf^l ehp^k maZg maZm h_ e^oZfblhe^ #/)3 f`*d`$' ]

GOP& ,%*& >hfiZkblhg h_ m^lm^] ]kn`l bg ma^ :# HXGYOROKTYOY OT \O\U ZllZr

O 7`cU 87 -( eWbV 1-% 6< % dOZcS & !W\ !U'[Z" C9)(**4 ,)-,. +)1-+, #+)4,,4(,)1,-$ ?SdO[Wa]ZS /)3,2 +)0-4/ #.)3/1(1)+.-$ 4[WRO\bSZ ,+4)0 7 +)+++. # \Y# ]

Z Nb`gb_b\Zgm ]b__^k^g\^ bg @? 0+ mh ]kn` bg [kZ\d^ml) < oZen^l p^k^ \hkk^\m^] _hk fnembie^ m^lmbg` nlbg` ma^ =hg_^kkhgb(Chef^l f^mah]) Kk^l^gm^] Zk^ ma^ @? 0+ oZen^l pbma ma^ 40 >D Zg] =' Zl p^ee Zl < oZen^l' _hk ]^m^kfbgZmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l)

,-0 1NGVZKX )

9WU& ,%*& 7T \O\U ]hl^(k^lihgl^ \nko^l _hk ^__b\Z\r h_ fhghma^kZib^l Z`Zbglm Z]nem :# HXGYOROKTYOY @__b\Z\r pZl \Ze\neZm^] Zl k^eZmbo^ gnf[^k h_ phkfl k^\ho^k^] _khf ma^ bgm^lmbg^l \hfiZk^] mh ma^ o^ab\e^ \hgmkhe bg i^k\^gmZ`^) ?ZmZ lahpg Zk^ f^Zgl É N@H) Oa^ ]kn` ]hlZ`^l bg ma^ (/ g^`Zmbo^ \hgmkhel p^k^ l^m mh ,+ f`*d` mh Zeehp eh` ,+ mkZgl_hkfZmbhg h_ ]hlZ`^l) Gh`blmb\ k^`k^llbhgl p^k^ \Ze\neZm^] pbma mhi Zg] [hmmhf oZen^l \hglmkZbg^] [^mp^^g + Zg] ,++ )

,-1 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

7T \O\U KLLKIZY UL JX[M IUSHOTGZOUTY >hf[bgZmbhgl h_ KA,+--< Zg] ]hf[bgZmbhgl h_ 0)+ f`*d` e^oZfblhe^ ienl .)20 f`*d` ]hfiZkblhgl h_ ma^ mak^^ ]b__^k^gm ]hlZ`^l m^lm^] _hk ^Z\a \hf[bgZmbhg ]^m^\m^] gh lb`gb_b\Zgm ]b__^k^g\^l) Oa^k^ p^k^ Zelh gh lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g \hf[bgZmbhgl h_ mkb[^g]bfb]bg^ Zg] e^oZfblhe^ Zg] ma^ ^jnboZe^gm ]hlZ`^l h_ ]hf[bgZmbhgl h_ ]$' k^li^\mbo^er) Chp^o^k' \hf[bgZmbhgl h_ mkb[^g]bfb]bg^ ienl e^oZfblhe^ Zg] h_ mkb[^g]bfb]bg^ ienl KA,+--< e^] mh Z lb`gb_b\Zgmer ab`a^k ^ebfbgZmbhg h_ ma^ phkf [nk]^g maZg mkb[^g]bfb]bg^' e^oZfblhe^ hk KA,+--< Zehg^ #Ab`) /(.= Zg] /(.?$)

,-2 1NGVZKX )

9WU& ,%+& @__^\ml h_ ]kn` \hf[bgZmbhgl bg \hfiZkblhg mh mk^Zmf^gml pbma bg]bob]nZe ]kn`l Zm ma^ lZf^ ]hlZ`^l

>hf[bgZmbhgl h_ <$ e^oZfblhe^ Zg] ]$ ]hf[bgZmbhgl p^k^ \hfiZk^] pbma lbg`e^ ]kn` mk^Zmf^gml pbma ma^ lZf^ ]hlZ`^l nlbg` ma^ FknldZe(RZeebl m^lm _heehp^] [r ma^ ?nggâl VUYZ NUI m^lm)

,-3 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

Nbg\^ Z gnf[^k h_ \hf[bgZmbhgl p^k^ lb`gb_b\Zgmer fhk^ ^__^\mbo^ maZg ma^ lbg`e^ ]kn`l' Z Rbe\hqhg kZgd(lnf m^lm Z`Zbglm ma^ ^qi^\m^] oZen^l h_ ma^ lnf h_ ma^ lbg`e^ ]kn` f^]bZgl pZl i^k_hkf^] mh ]b__^k^gmbZm^ Z]]bmbo^ Zg] lrg^k`blmb\ ^__^\ml)

9UXVNURUMOIGR KLLKIZY UL JX[M ZXKGZSKTZY UT :# HXGYOROKTYOY H_ KRKIZXUT SOIXUYIUV_ N\Zggbg` ^e^\mkhg fb\khl\hir lmn]b^l h_ :# HXGYOROKTYOY mk^Zm^] OT \O\U pbma #b$ ,)+ f`*d` KA,+--<' #bb$ ,++ f`*d` Zfb]Zgm^e' #bbb$ -)0 f`*d` ]k^fhiahk @G*pZm^k$ p^k^ i^k_hkf^] mh bgo^lmb`Zm^ ma^ ^__^\ml h_ ma^ ]b__^k^gm ]kn` \eZll^l hg ma^ ho^kZee fhkiaheh`r h_ ma^ phkfl) Ankma^kfhk^' mk^Zmf^gml pbma \hf[bgZmbhgl h_ #b$ ,)+ f`*d` KA,+--< Zg] -)0 f`*d` ]' ?$ Zl p^ee Zl ma^ p^ee(]^o^ehi^] \^iaZeb\ \Zi pbma ma^ mkbkZ]bZm^ fhnma hi^gbg` #Ab`) /( /?$ Zk^ \hg\^kg^]) Oabl bg]b\Zm^l maZm ma^ phkfl p^k^ bgmZ\m Zg] bg Zg ngl\Zma^] \hg]bmbhg [^_hk^ _bqZmbhg) B^g]^k li^\b_b\ \aZkZ\m^kblmb\l ln\a Zl ma^ \hineZmhkr [nklZ Zm ma^ ihlm^kbhk ^g] h_ fZe^ phkfl #Ab`) /( /<$' Zl p^ee Zl ma^ oneoZ Zi^kmnk^ lnkkhng]^] [r mab\d ebil Zg] ma^ Zgnl Zm ma^ [Zl^ #Ab`) /( /@$ Zg] ma^ iZbk h_ iaZlfb]l Zm ma^ mbi h_ ma^ mZbe h_ _^fZe^l #Ab`) /( /A$ Zk^ beenlmkZm^]) Oa^ pkbgde^ _hkfZmbhg h_ ma^ \nmb\ne^ bg Ab`) /( /A bl ]n^ mh ma^ _bqZmbhg) Oa^ ho^kZee laZi^ h_ ma^ KA,+--<(mk^Zm^] phkfl pZl bg]blmbg`nblaZ[e^ _khf ma^ ieZ\^[h( mk^Zm^] :# HXGYOROKTYOY #Ab`) /( 0<' =$) Jger Zm Z o^kr ab`a fZ`gb_b\Zmbhg' l^o^kZe lfZee \nmb\neZk dgh[l p^k^ h[l^ko^] g^qm mh ma^ ehg`bmn]bgZe kb]`^l Z_m^k mak^^ mk^Zmf^gml pbma , f` KA,+--<*d` [h]r p^b`am #Ab`) /( 0>$) Chp^o^k' mk^Zmf^gml pbma e^oZfblhe^ aZ] lb`gb_b\Zgm ^__^\ml hg ma^ mhmZe [h]r laZi^ h_ [hma fZe^ Zg] _^fZe^ phkfl #Ab`) /( 0?' @$) Ra^k^Zl ma^ pahe^ [h]r h_ fZe^ phkfl pZl l^o^k^er \hgmkZ\m^] #Ab` ) /( 0?$' ma^ fhkiaheh`b\Ze \aZg`^l

,-4 1NGVZKX ) h_ ma^ _^fZe^l p^k^ ebfbm^] mh ma^ ihlm^kbhk iZkm #Ab`) /( 0@$' pab\a Zii^Zk^] mh [^ lmkhg`er lphee^g' ik^lnfZ[er ]n^ mh ma^ \hfie^m^er k^mkZ\m^] \Zn]Ze ^g] #Ab`) /( 0@' A$) NbfbeZk ^__^\ml p^k^ h[l^ko^] pa^g :# HXGYOROKTYOY p^k^ mk^Zm^] pbma Zfbghia^greZfb]bg^l #Ab`) /( 1$) Nbg\^ mk^Zmf^gml pbma Zfb]Zgm^e' ]$) Jger mkb[^g]bfb]bg^ \Znl^] ^qmknlbhg h_ ma^ mph mpblm^] lib\ne^l #Ab`) /( 1@' A$) Nbg\^ ghg^ h_ ma^ \hf[bgZmbhgl Zem^k^] ma^ ^__^\ml h_ ma^ Zfbghia^greZfb]bg^l Zehg^' ma^l^ bfZ`^l Zk^ ghm lahpg)

,.+ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

9WU& ,%,& Jo^kZee Zii^ZkZg\^ h_ ngmk^Zm^] Z]nem :# HXGYOROKTYOY [r l\Zggbg` ^e^\mkhg fb\khl\hir

<$ HZe^ phkf pbma ma^ \hineZmhkr [nklZ Zm ma^ ihlm^kbhk ^g] h_ ma^ mZbe #Zkkhp$) Oa^ phkf bl ZiikhqbfZm^er -/++ f ehg` Zg] 30 f pb]^ Zm fb][h]r #pb]^lm iZkm$) =$ ?^mZbe^] ob^p h_ Zg Zfiab] #l^^ Zkkhp$ h_ Z fZe^ phkf' Z l^\k^mhkr hk`Zg l^\k^mbg` K#M# <>a@) >$ ?^mZbe^] ob^p h_ ma^ \nmb\ne^ h_ ma^ fb][h]r h_ Z fZe^ phkf) Oph ehg`bmn]bgZe kb]`^l #hg^ bl fZkd^] [r Zg Zkkhp$ Zg] ngli^\b_b^] ]^[kbl Zk^ ik^l^gm) ?$

,., 1NGVZKX )

9WU& ,%-& Jo^kZee Zii^ZkZg\^ h_ Zgma^efbgmb\(mk^Zm^] Z]nem :# HXGYOROKTYOY [r l\Zggbg` ^e^\mkhg fb\khl\hir

Rhkfl bg # <(>$ p^k^ mk^Zm^] pbma KA,+--< Zg] bg #?(A$ pbma e^oZfblhe^) <$ DlheZm^] Z]nem fZe^ phkf Z_m^k mak^^ mk^Zmf^gml pbma , f` KA,+--<*d` [h]r p^b`am) =$ A^fZe^ phkf Z_m^k mak^^ KA,+--<(mk^Zmf^gml) Oa^ ho^kZee Zii^ZkZg\^ bl bg]blmbg`nblaZ[e^ _khf ngmk^Zm^] fZe^l Zg] _^fZe^l) >$ ?^mZbe^] ob^p h_ ma^ \nmb\ne^ Z_m^k mk^Zmf^gml pbma KA,+--<) I^qm mh ma^ ehg`bmn]bgZe kb]`^l' l^o^kZe lfZee m^`nf^gmZe dgh[l #l^^ Zkkhpl$ Zk^ ik^l^gm) ?$ HZe^ phkf Z_m^k mak^^ mk^Zmf^gml pbma -)0 f` e^oZfblhe^*d` [h]r p^b`am) Oa^ pahe^ [h]r bl lmkhg`er \hgmkZ\m^] Zg] lphee^g) @$ <]nem _^fZe^ phkf Z_m^k mk^Zmf^gml pbma e^oZfblhe^) NbfbeZk mh ma^ fZe^ phkf bg ?$' ma^ ihlm^kbhk ^g] Zii^Zkl mh [^ \hgmkZ\m^] Zg] lphee^g) A$ Khlm^kbhk ^g] h_ Z _^fZe^ phkf Z_m^k mak^^ e^oZfblhe^(mk^Zmf^gml) Oa^ \Zn]Ze ^g] bl Zefhlm \hfie^m^er k^mkZ\m^])

,.- 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

9WU& ,%.& Hhkiaheh`r h_ Z]nem :# HXGYOROKTYOY mk^Zm^] pbma Zfbghia^greZfb]bg^l [r l\Zggbg` ^e^\mkhg fb\khl\hir

<$ <]nem _^fZe^ phkf Z_m^k mak^^ ]hl^l h_ ,++ f` Zfb]Zgm^e*d` [h]r' lahpbg` Z lmkhg`er \hgmkZ\m^] Zg] lphee^g [h]r) =$ Oa^ \^iaZeb\ \Zi h_ Z ]$ OZbe k^`bhg h_ Z _^fZe^ phkf Z_m^k mak^^ mk^Zmf^gml pbma -)0 f` mkb[^g]bfb]bg^*d` [h]r p^b`am) Oa^ \Zn]Ze ^g] bl k^mkZ\m^] ni mh ma^ Zgnl Zi^kmnk^) Oa^ oneoZ Zi^kmnk^ [^\Zf^ \hfie^m^er bgoblb[e^) ?$ HZe^ phkf Z_m^k mak^^ ]hineZmhkr [nklZ _khf Z fZe^ phkf mk^Zm^] pbma mkb[^g]bfb]bg^) Oph mpblm^] lib\ne^l #l^^ Zkkhp$ Zk^ ^qmkn]^] _khf ma^ a^k^ ghm lahpg \ehZ\Z) < lfZee ]hklZe Zg] mph eZk`^ eZm^kZe eh[^l lnkkhng] ma^ \ehZ\Z) A$ ?^mZbe^] ob^p h_ ^qmkn]^] \hineZmhkr lib\ne^l h_ Z mkb[^g]bfb]bg^(mk^Zm^] Z]nem fZe^ phkf)

,.. 1NGVZKX )

GOP& ,%+& KeZlfZ iaZkfZ\hdbg^mb\ iZkZf^m^kl h_ ]^Z\reZm^] Zfb]Zgm^e Z_m^k hkZe mk^Zmf^gm pbma ]^Z\reZm^] Zfb]Zgm^e hk mkb[^g]bfb]bg^

KZkZf^m^k Pgbm ]

>fZq `*G ,.3- É ,., ,//0 É 4/

eZlm `!a*G /-01 É ,/0 .4-2 É ,1,

Z [ <_m^k mk^Zmf^gm pbma ] fZq ' fZqbfZe ieZlfZ \hg\^gmkZmbhg6

eZlm ' Zk^Z ng]^k ma^ \nko^ mh ma^ eZlm f^Zlnk^f^gm mbf^ ihbgm6 É N@H6 Ih lb`gb_b\Zgm ]b__^k^g\^l p^k^ h[l^ko^] [^mp^^g mk^Zmf^gm pbma mkb[^g]bfb]bg^ Zg] ]

$%! 2111 ",(#%+$(*($(+%

211 $%! //4&.*)0

1 21 31 "(*%//'0

9WU& ,%/& KeZlfZ iaZkfZ\hdbg^mb\ ZgZerl^l h_ ]

H^Zg ieZlfZ(\hg\^gmkZmbhgl #É N?$ h_ ]

,./ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,&- 7WaQcaaW]\

Rbmabg ma^ bgbmbZe ^qi^kbf^gml ik^l^gm^] bg mabl fZgnl\kbim' ma^ k^ikh]n\b[bebmr h_ bgh\nenf lbs^ Zg] phkf k^\ho^kr pZl bgo^lmb`Zm^]) ?ZmZ lahp k^eZmbo^er ab`a oZkbZ[bebmr [^mp^^g bg]bob]nZe ZgbfZel pbmabg ^Z\a [eh\d [nm ]b__^k^g\^l [^mp^^g [eh\dl p^k^ ghm lmZmblmb\Zeer lb`gb_b\Zgm) Oabl ng]^kebg^l ma^ k^jnbk^f^gm h_ k^eZmbo^er ab`a gnf[^kl h_ ZgbfZel pa^g m^lmbg` Zgma^efbgmb\ ]kn`l mh h[mZbg f^Zgbg`_ne ]ZmZ) Cb`a oZkbZ[bebmr pZl Zelh h[l^ko^] _hk bgm^kf^]bZm^ ^__b\Z\r kZm^l bg ma^ ]kn` mk^Zm^] `khnil' ab`aeb`ambg` ma^ _Z\m maZm ma^ gnf[^k h_ ZgbfZel ^ll^gmbZeer \hgmkb[nm^ mh ma^ `hh]g^ll h_ _bm #]hl^(k^lihgl^ \nko^$ Zg] ma^ k^eZm^]

]^m^kfbgZmbhg h_ ma^ @? 0+ ) D_ hger bgm^kf^]bZm^ ^__b\Z\r kZm^l Zk^ ZoZbeZ[e^' bgm^kik^mZmbhg h_ ]ZmZ pbee k^fZbg oZ`n^ Zg] ma^k^_hk^ bg\k^Zlbg` ma^ kbld h_ fblbgm^kik^mZmbhg) Oa^ lmn]r ik^l^gm^] a^k^ Zbf^] Zm ma^ ^oZenZmbhg Zg] \hfiZkblhg h_ ma^ OT \O\U g^fZmh\b]Ze ^__b\Z\r h_ ma^ \r\ehh\mZ]^ilbi^imb]^ KA,+--<' ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]

@? 0+ oZen^ h_ ,)-,. f`*d` Zg] [r \hfie^m^ ^ebfbgZmbhg h_ phkf [nk]^gl nlbg` mak^^ ]hlZ`^l h_ Zm e^Zlm -)0 f`*d` KA,+--< ^Z\a) Oabl \hkkh[hkZm^l Z gnf[^k h_ ik^obhnler in[ebla^] OT \OZXU Zg] OT \O\U lmn]b^l lahpbg` maZm KA,+--< bl ab`aer ^__^\mbo^ Z`Zbglm `Zlmkhbgm^lmbgZe g^fZmh]^l bg\en]bg` ma^ kZm ahhdphkf #_hk k^ob^p l^^ V2W$) Dg OT \OZXU ZllZrl bm aZl [^^g lahpg maZm KA,+--< bl Zgma^efbgmb\Zeer Z\mbo^ Z`Zbglm ma^ bg_^\mbo^ G. Zl p^ee Zl ma^ Z]nem

,.0 1NGVZKX ) lmZ`^ h_ :# HXGYOROKTYOY V,3W) Oa^ OT \O\U k^lneml ik^l^gm^] a^k^ Z`k^^ pbma Z ik^obhnl lmn]r' pab\a ^fiehr^] hkZe mk^Zmf^gml hg mak^^ \hgl^\nmbo^ ]Zrl lmZkmbg` Zm ]Zr _bo^ i)b) ?hlZ`^l h_ -)0 f`*d` KA,+--< k^lnem^] bg Zg Zefhlm \hfie^m^ ^ebfbgZmbhg h_ :# HXGYOROKTYOY V-.W) Oa^k^_hk^' ma^ ^__b\Z\r h_ KA,+--< Z`Zbglm :# HXGYOROKTYOY Zii^Zkl mh [^ bg ma^ lZf^ ]hl^ kZg`^ Zl ma^ k^jnbk^] ^fh]^ilb]^ ]hlZ`^ #-)0 f`*d`' [nm bg Z lbg`e^ hkZe mk^Zmf^gm k^`bf^$ V-/W) Oa^ fhkiaheh`r h_ :# HXGYOROKTYOY Z_m^k KA,+--< mk^Zmf^gml pZl eZk`^er ng\aZg`^] Zl lahpg [r l\Zggbg` ^e^\mkhg fb\khl\hir' ^q\^im _hk l^o^kZe lfZee \nmb\neZk dgh[l g^qm mh ma^ ehg`bmn]bgZe kb]`^l) Nbg\^ ma^ \r\ehh\mZ]^ilbi^imb]^l Zk^ dghpg mh \Znl^ _eZ\\b] iZkZerlbl' bm pZl ghm ng^qi^\m^] mh _bg] hger fbgbfZe \aZg`^l ]n^ mh KA,+--< mk^Zmf^gm) Chp^o^k' ma^ \Znl^ h_ ma^ \nmb\neZk dgh[l k^fZbgl ngdghpg)

Dg ma^ ik^l^gm lmn]r' ma^ OT \O\U @> 0+ _hk Zfb]Zgm^e pZl Z[hnm .+(_he] ab`a^k maZg maZm h_ mkb[^g]bfb]bg^ Zg] ]

@? 0+ oZen^ h_ ,+4)0 f`*d` Zg] Zg Zefhlm \hfie^m^ ^ebfbgZmbhg h_ ma^ phkf [nk]^g lmZkmbg` Zm -++ f`*d`) M^`Zk]bg` ma^ OT \O\U ^__b\Z\r h_ ]

:# HXGYOROKTYOY nlbg` Z lbg`e^(mk^Zmf^gm k^`bf^g Z`Zbglm Z]nem lmZ`^l' @? 4+ oZen^l h_

0),+/ f`*d` Zg] 3)/.0 f`*d` p^k^ k^ihkm^]' k^li^\mbo^er V-0W) Dg \hgmkZlm' ma^ @? 0+ oZen^l h_ ma^ ik^l^gm lmn]r p^k^ .)3 f`*d` Zg] .)/ f`*d` _hk ] h_ ,12/ g` !a*fe Z_m^k hkZe ]hlZ`^ h_ ,0+ f`*d` mkb[^g]bfb]bg^ mh kZml) M^Zlhg _hk ma^l^ lmkbdbg` ]b__^k^g\^l k^fZbgl ng\e^Zk' bg iZkmb\neZk lbg\^ SbZh KZ GR# V,-W ]b] ghm ikhob]^ Zgr ^qi^kbf^gmZe ]^mZbel) Oa^ o^kr lbfbeZk mbf^ \hnkl^ h_ ]

,.1 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY ik^l^gm lmn]r Z_m^k mk^Zmf^gm pbma ]k^fhiahk*pZm^k ]bli^klbhg fb`am [^ ab`a^k maZg maZm h_ ]aM Z`hgblml hg ma^ ho^kZee lnk_Z\^ h_ Z iZkZlbmb\ g^fZmh]^ nlbg` l\Zggbg` ^e^\mkhg fb\khl\hir m^\agbjn^l) aMl V,2W) Oa^k^_hk^' ma^ ahfh`^ghnl ^__^\ml hg ma^ fhkiaheh`r h_ :# HXGYOROKTYOY Zk^ \hfik^a^glbo^) Nbg\^ Z\mboZmbhg h_ g<>aMl k^lneml bg liZlmb\ iZkZerlbl' lb`gb_b\Zgm ^__^\ml hg ma^ mhmZe [h]r laZi^ h_ ma^ phkfl Zk^ ^qi^\mZ[e^) ?b__^k^g\^l bg ma^ bgm^glbmr h_ \hgmkZ\mbhgl Zg] lp^eebg`l h_ ma^ phkfl fb`am [^ ]n^ mh ]b__^k^gm bgmkbglb\ ]kn` \hg\^gmkZmbhgl*ZoZbeZ[bebmr) Oa^ k^Zlhg _hk ^qmknlbhg h_ ma^ mph mpblm^] lib\ne^l hger Z_m^k mkb[^g]bfb]bg^ [nm ghm ]

,.2 1NGVZKX ) mkb[^g]bfb]bg^ p^k^ fhk^ ^__b\Z\bhnl maZg \hf[bgZmbhgl \hgmZbgbg` ]aM ln[ngbml [^mp^^g g^fZmh]^ li^\b^l Zl p^ee Zl [^mp^^g eb_^ \r\e^ lmZ`^l fb`am k^lnem bg ]b__^k^gm l^glbmbobmb^l mh bg]bob]nZe \ahebg^k`b\ Zgma^efbgmb\l V-2'-3W [nm \hne] Zelh bg_en^g\^ ma^ bgm^kZ\mbhg h_ ]kn`l) Oa^ ^__^\ml h_ \hf[bgZmbhgl h_ \r\ehh\mZ]^ilbi^imb]^l pbma Zfbghia^greZfb]bg^l aZo^ hger [^^g bgo^lmb`Zm^] OT \OZXU Z`Zbglm :# HXGYOROKTYOY Zg] ?# YVOXGROY Zg] ma^r p^k^ ghm lb`gb_b\Zgmer lni^kbhk bg \hfiZkblhg mh ^bma^k h_ ma^ k^li^\mbo^ lbg`e^ ]kn`l V,3W) >r\ehh\mZ]^ilbi^imb]^l [hhlm ma^ bgab[bmhkr lrlm^f Zg] e^Z] mh ari^kiheZkblZmbhg h_ \^eel pa^k^Zl Zfbghia^greZfb]bg^l Z\mboZm^ ma^ ^q\bmZmhkr lrlm^f' e^Z]bg` mh f^f[kZg^ ]^iheZkblZmbhg) Nbg\^ [hma ]kn` \eZll^l aZo^ hiihlbm^ ^__^\ml hg ma^ f^f[kZg^ ihm^gmbZe h_ ^q\bmZ[e^ \^eel' bm pZl ng\e^Zk pa^ma^k ma^ \hf[bgZmbhgl fb`am k^lnem bg Z]]bmbo^*lrg^k`blmb\ hk ^o^g ZgmZ`hgblmb\ ^__^\ml) Oa^ k^lneml ik^l^gm^] a^k^ lahp maZm Z]]bmbo^ ^__^\ml Zk^ ihllb[e^ Zemahn`a [hma ]kn` \eZll^l Z\m hg g^nkheh`b\Ze lrlm^fl maZm ZgmZ`hgbl^ ^Z\a hma^k) Dg \hg\enlbhg' \r\ehh\mZ]^ilbi^imb]^l fb`am [^ Zg bgm^k^lmbg` \eZll _hk ma^ mk^Zmf^gm h_ anfZg NOCl' lbg\^ ma^r fb`am Z\ab^o^ Z \hfie^m^ ^ebfbgZmbhg h_ ma^ phkf [nk]^g bg Z lbg`e^(mk^Zmf^gm k^`bf^g V3W) ?n^ mh Z lb`gb_b\Zgm k^]n\mbhg h_ \hlml Zg] fZgZ`^f^gm ^__hkml' lbg`e^ ]hlZ`^l lahne] [^ ma^ ik^_^kk^] mk^Zmf^gm(l\a^f^' bg]^i^g]^gmer h_ ma^ jn^lmbhg5 lbg`e^ ]kn` hk \hf[bgZmbhg: =^\Znl^ h_ ma^bk bg\k^Zl^] ^__b\Z\r' [khZ]^k Z\mbobmr li^\mknf Zg] ]^\k^Zl^] kbld mh l^e^\m _hk ]kn` k^lblmZg\^' \hf[bgZmbhgl h_ \ahebg^k`b\ ]kn`l pbma \r\ehh\mZ]^ilbi^imb]^l lahne] [^ _nkma^k bgo^lmb`Zm^]) Chp^o^k' [^_hk^ _nkma^k m^lmbg` h_ ihm^gmbZe ]kn` \hf[bgZmbhgl bg\en]bg` ma^ Zfbghia^greZfb]bg^l' ma^k^ bl bg nk`^gm g^^] mh h[mZbg fhk^ ]ZmZ hg ma^ lZ_^mr h_ mabl ]kn` \eZll V-4W)

,.3 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,&. 4QY\]eZSRUS[S\ba

Oa^ Znmahkl phne] ebd^ mh maZgd Kkh_) ?k) Mhe_ @gms^khma Zg] OahfZl B{gma^k #?k^l]^g' B^kfZgr$ _hk ma^bk a^ei pbma l\Zggbg` ^e^\mkhg fb\khl\hir)

,&/ 9W\O\QWOZ ac^^]`b

Oa^ =Zr^k C^Zema>Zk^ Zk^

,&0 6]\TZWQb ]T W\bS`Sab

?) Fned^ Zg] F) AkZZms Zk^ ^fiehr^^l h_ =Zr^k C^Zema>Zk^ khiN\b^g\^ Zk^

,.4 1NGVZKX )

,&1 ESTS`S\QSa

,) Kkb\aZk] MF' =ZlZg^s HB' =hZmbg =<' H\>Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 1' ^,0/4) -) Ub^`^e[Zn^k F' Ni^b\a =' HZnl^sZae ?' =hl M' F^bl^k E' Pmsbg`^k E' -+,-' @__^\m h_ lZgbmZmbhg hg lhbe(mkZglfbmm^] a^efbgma bg_^\mbhg5 lrlm^fZmb\ k^ob^p Zg] f^mZ(ZgZerlbl) KGhN H^] 4' ^,++,,1-) .) Chm^s K' -+,,' @geZk`bg` ma^ "' Ndn\^ KE' ohg NZflhg(Cbff^elmc^kgZ B' HZ^]^k N' Che]lphkma K' Khfkhr R' Q^k\knrll^ E' -+,-' Rhke] hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) 4) Bn^lm H' =nee F' RZed^k ME' hgghk Q' CZk]^k <' Che]^g(?r^ G' Chii^k I<' -++2' Oa^ \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e' NGJ(,' bl k^jnbk^] _hk ma^ Z\mbhg h_ ma^ gho^e \r\eh(h\mZ]^ilbi^imb]^ Zgma^efbgmb\' ^fh]^ilb]^' bg 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' ,022(,033) ,+) R^es >' Fk{`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fk{\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+)

,/+ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ :# HXGYOROKTYOY

,,) ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' NZg`lm^k I>' >he^l B>' -++0' @__b\Z\r h_ mph \r\ehh\mZ]^ilbi^imb]^l' KA,+--< Zg] ^fh]^ilb]^' Z`Zbglm Zgma^efbgmb\(k^lblmZgm g^fZmh]^l bg la^^i Zg] \Zmme^) KZkZlbmhe ,.+' ./.(./2) ,-) SbZh NC' Cnb(Hbg` R' OZgg^k H' Pmsbg`^k E' >ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) ,.) Rheep^[^k C' Ib^f^kl @' Aen\d^ R' ' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l M ? ,+' 3.(4+) ,0) Okbmm^g G' Iphln P' QZk`Zl H' F^bl^k E' -+,-' 7T \OZXU Zg] OT \O\U ^__b\Z\r h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Zehg^ Zg] bg \hf[bgZmbhg Z`Zbglm ma^ ahhdphkfl 6KROMSUYUSUOJKY HGQKXO Zg] /TI_RUYZUSG IK_RGTOI[S ) <\mZ Okhi ,--' ,+,(,+2) ,1) Fned^ ?' Fk{\d^g E' R^es >' ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' -+,-' 7T \O\U ^__b\Z\r h_ ma^ Zgma^efbgmb\ mkb[^g]bfb]bg^ Z`Zbglm ma^ \^lmh]^ 6_SKTURKVOY SOIXUYZUSG bg Z \hgmkhee^] eZ[hkZmhkr mkbZe) <\mZ Okhi ,-.' 23(3/) ,2) Cn T' SbZh NC' ' =bll^m N<' H\FZr >C' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 bl bm _^Zlb[e^ bg I^p U^ZeZg] mh ]^eZr ma^ ^f^k`^g\^ h_ k^lblmZg\^ mh Z g^p Zgma^efbgmb\ \eZll: I U Q^m E 02' ,3,(,4-) -+) =^Z\a HE' Nmk^bm OB' <]]bll ?B' Kkhli^k^ M' Mh[^kml EH' GZffb^ KE' ,444'

,/, 1NGVZKX )

-,) Fghii N' HhaZff^] F<' Ni^b\a =' CZmm^g]hk_ E' FaZfbl DN' FaZfbl ebg Dg_^\m ?bl 0,' ,/-+(,/-3) --) Ni^b\a =' r\ehh\mZ]^ilbi^imb]^l ( Z g^p \eZll h_ Zgma^efbgmb\Zeer Z\mbo^ \hfihng]l) KZkZlbmhe M^l 33' /3,(/33) -0) Sn^ E' SbZh NC' Sn GG' LbZg` CL' -+,+' Oa^ ^__^\m h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Z`Zbglm :KIGZUX GSKXOIGT[Y bg `he]^g aZflm^kl Zg] :OVVUYZXUTM_R[Y HXG`OROKTYOY bg kZml) KZkZlbmhe M^l ,+1' 220(23,) -1) Ohfebglhg B' <' Rhh]l M<' ,430' Oa^ ^__^\ml h_ Zfb]Zgm^e #=' Ghp^ <' J"BkZ]r E' Fhii NM' =^agd^' EH' -++4' ?hl^(k^lihgl^ ZllZr m^fieZm^l _hk OT \OZXU Zll^llf^gm h_ k^lblmZg\^ mh [^gsbfb]Zshe^ Zg] gb\hmbgb\ Z\^mre\ahebg^ k^\^imhk Z`hgblm ]kn`l bg anfZg ahhdphkfl) aZko^m >G' I^o^n >' -+,-' G^oZfblhe^ k^\^imhkl5 Z l^\hg] ZpZd^gbg`) Ok^g]l KZkZlbmhe -3' -34(-41) -4) @i^ >' FZfbgldr M' -+,.' I^p Z]oZg\^f^gm bg Zgma^efbgmb\ ]kn`l bg o^m^kbgZkr f^]b\bg^) Ok^g]l KZkZlbmhe -4' ,-4(./)

,/- Chapter 5

Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterised trichurosis model in mice

Kulke D., Krücken J., Harder A., von Samson-Himmelstjerna G.

PLoS Neglected Tropical Diseases 2014, 8 (2) e2698.

http://dx.doi.org/10.1371/journal.pntd.0002698 1NGVZKX *

- 8TTWQOQg ]T QgQZ]]QbORS^aW^S^bWRSa O\R O[W\]^VS\gZO[WRW\Sa OUOW\ab ZO`dOZ$ W[[Obc`S O\R [Obc`S ORcZb abOUSa ]T O ^O`OaWb]Z]UWQOZZg QVO`OQbS`WaSR b`WQVc`]aWa []RSZ W\ [WQS

-&) 4Pab`OQb

Oa^ `^gnl ?XOIN[XOY bg\en]^l iZkZlbm^l h_ fZchk k^e^oZg\^ bg o^m^kbgZkr Zg] anfZg f^]b\bg^) ?^libm^ l^kbhnl ^\hghfb\ ehll^l Zg] ^ghkfhnl bfiZ\m hg in[eb\ a^Zema' mk^Zmf^gm himbhgl Z`Zbglm pabiphkfl Zk^ o^kr ebfbm^]) <]]bmbhgZeer' ma^k^ bl Zg h[obhnl eZ\d h_ ZiikhikbZm^er \aZkZ\m^kbl^] ^qi^kbf^gmZe bg_^\mbhg fh]^el) Oa^k^_hk^' Z ]^mZbe^] iZkZlbmheh`b\Ze \aZkZ\m^kbsZmbhg h_ Z ?XOIN[XOY S[XOY blheZm^ pZl i^k_hkf^] bg >02=G*,+ fb\^) Nn[l^jn^gmer' ma^ OT \O\U ^__b\Z\b^l h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]

_heehpbg` bgmkZi^kbmhg^Ze #@? 0+ oZen^l h_ 1), ol) 00)2 f`*d`$ hk ln[\nmZg^hnl #@? 0+ oZen^l h_ ,0)- ol) --0)2 f`*d`$ Z]fbgblmkZmbhg) Jger fbgbfZe ]b__^k^g\^l p^k^ h[l^ko^] _heehpbg` hkZe

Z]fbgblmkZmbhg #@? 0+ oZen^l h_ -)2 ol) 0)- f`*d`$) Okbie^ Zg] fhlm lbg`e^ hkZe ]hl^l pbma fh]^kZm^ mh ab`a ]hlZ`^l h_ KA,+--< lahp^] \hfie^m^ ^__b\Z\r Z`Zbglm ablmhmkhib\ l^\hg] lmZ`^ eZkoZ^ #. ! ,++ f`*d` hk , ! -0+ f`*d`$' _nkma^k ]^o^ehi^] eZkoZ^ #. ! ,+ f`*d` hk ,! ,++ f`*d`$ Zg] bffZmnk^ Z]neml #. ! ,+ f`*d` hk , ! ,++ f`*d`$) Cblmhmkhib\ _bklm lmZ`^ eZkoZ^ p^k^ hger ^ebfbgZm^] Z_m^k mak^^ ]hl^l h_ KA,+--< #. ! ,++ f`*d`$ [nm ghm Z_m^k Z lbg`e^ ]hl^) Oa^l^ k^lneml bg]b\Zm^ maZm ma^ \r\ehh\mZ]^ilbi^imb]^l Zk^ Z ]kn` \eZll pbma ikhfblbg` \Zg]b]Zm^l _hk _nkma^k ^oZenZmbhg _hk ma^ mk^Zmf^gm h_ mkb\ankhlbl h_ anfZgl Zg] ebo^lmh\d ZgbfZel bg lbg`e^ ]hl^ k^`bf^gl)

,// 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

-&* 4cbV]` ac[[O`g

Ok^Zmf^gm himbhgl Z`Zbglm pabiphkf bg_^\mbhgl h_ anfZgl Zg] ebo^lmh\d Zk^ o^kr ebfbm^] Zg] ^o^g Zgma^efbgmb\l k^\^gmer bgmkh]n\^] bgmh ma^ fZkd^m ]h ghm lb`gb_b\Zgmer bfikho^ ma^ lbmnZmbhg) C^k^' p^ ^oZenZm^] f^f[^kl h_ mph k^eZmbo^er g^p ]kn` \eZll^l' ma^ Zfbghia^greZfb]bg^l #Zfb]Zgm^e' ]abgZ' ^fh]^ilb]^ bl ma^ g^fZmh\b]Ze \hfihg^gm h_ ]^phkf^kl _hk \Zml Zg] ]h`l) Rbma ma^ ^q\^imbhg h_ Zfb]Zgm^e' Zee ]kn`l lahp^] `hh] ^__b\Z\b^l Z`Zbglm Z]nem pabiphkfl nlbg` mak^^ \hgl^\nmbo^ ]hl^l) ?n^ mh \hglb]^kZmbhgl k^`Zk]bg` ]kn` lZ_^mr Zg] ikb\^' KA,+--< pZl _nkma^k ^oZenZm^] Z`Zbglm ablmhmkhib\ G, Zg] G-' _nkma^k ]^o^ehi^] eZkoZ^' bffZmnk^ Zg] fZmnk^ Z]neml nlbg` Z lbg`e^ hk mak^^ \hgl^\nmbo^ ]hl^l) Oak^^ ]hl^l ^ebfbgZm^] Zee lmZ`^l pabe^ Z lbg`e^ ]hl^ pZl bg^__b\b^gm Z`Zbglm ablmhmkhib\ _bklm lmZ`^ eZkoZ^) Dg `^g^kZe' ab`a^k ]hl^l p^k^ k^jnbk^] _hk ^Zker lmZ`^l bg \hfiZkblhg mh lmZ`^l ikhmkn]bg` bgmh ma^ `nm enf^g) Nbg\^ hger Z o^kr [Zlb\ _hkfneZmbhg h_ ]kn`l pZl m^lm^]' _nkma^k bfikho^f^gm \Zg [^ ^qi^\m^] _khf himbfbl^] _hkfneZmbhgl) >r\ehh\mZ]^ilbi^imb]^l lahne] ma^k^_hk^ [^ \hglb]^k^] Zl \Zg]b]Zm^l _hk ^oZenZmbhg mh mk^Zm ?XOIN[XOY lii) bg_^\mbhgl bg ebo^lmh\d Zg] anfZgl)

,/0 1NGVZKX *

-&+ <\b`]RcQbW]\

<[hnm -+ fZchk anfZg a^efbgmahl^l aZo^ Z lb`gb_b\Zgm bfiZ\m hg `eh[Ze in[eb\ a^Zema V,W) Nbg\^ Z ab`aer ]blikhihkmbhgZm^ laZk^ h_ ma^ [nk]^g h\\nkl bg ]^o^ehibg` Zk^Zl h_ ln[(NZaZkZg <_kb\Z'

,/1 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

Dg Z]]bmbhg mh bml k^e^oZg\^ bg anfZg f^]b\bg^' ma^ `^gnl ?XOIN[XOY Zelh aZl Zg ^ghkfhnl bfiZ\m hg o^m^kbgZkr f^]b\bg^) Ahk bglmZg\^' ?# \[RVOY ' ma^ ]h` pabiphkf' \Znl^l Zg bgm^lmbgZe iZkZlbmhlbl h_ \ebgb\Ze k^e^oZg\^ Zg] bl Zelh lnli^\m^] mh [^ shhghmb\ V,-W) Chp^o^k' l^o^kZe Zgma^efbgmb\l k^`blm^k^] _hk nl^ bg ]h`l ln\a Zl ]b^mare\Zk[ZfZsbg^' ibi^kZsbg^' bo^kf^\mbg Zg] irkZgm^e eZ\d ^__b\Z\r Z`Zbglm ?# \[RVOY l^o^k^er ebfbmbg` ma^ \ahb\^ h_ ]kn` _hk ]^phkfbg` V,-W) Dg lpbg^' bg_^\mbhgl pbma ?# Y[OY! ma^ ]hl^(ebfbmbg` g^fZmh]^ _hk Zee k^e^oZgm Zgma^efbgmb\ ]kn` \eZll^l' e^Z] mh k^]n\^] `khpma kZm^l Zg] ma^k^_hk^ k^lnem bg lb`gb_b\Zgm ^\hghfb\ ehll^l V,.W) AbgZeer' ]n^ mh ma^ ehg` i^kbh] h_ ik^iZm^g\r h_ ?XOIN[XOY lii) Zg] ma^ eZ\d h_ ^__b\Z\r h_ fhlm ]kn`l Z`Zbglm ablmhmkhib\ eZkoZe _hkfl' mph [eh\dl pbma hg^ mh mak^^ ]hl^l ^Z\a Zk^ nlnZeer g^\^llZkr mh \hfie^m^er ^ebfbgZm^ ma^ iZkZlbm^l V,-W) Dm bl ma^k^_hk^ h[obhnl' maZm ma^ ]^o^ehif^gm h_ g^p' lZ_^ Zg] ab`aer ^__b\Z\bhnl ]kn`l mh mk^Zm lhbe(mkZglfbmm^] g^fZmh]^ bg_^\mbhgl bl nk`^gmer k^jnbk^]) Dg iZkmb\neZk' g^p ]kn`l _hk ma^ mk^Zmf^gm h_ ?XOIN[XOY lii) nlbg` Z lbg`e^ ]hl^ phne] lb`gb_b\Zgmer bg\k^Zl^ mk^Zmf^gm himbhgl bg [hma' anfZg Zg] o^m^kbgZkr f^]b\bg^) Oa^k^_hk^' ma^ ^oZenZmbhg h_ ma^ ^__b\Z\r h_ ikhfblbg` ]kn` \Zg]b]Zm^l Z`Zbglm pabiphkfl bl Zg ^ll^gmbZe lm^i mhpZk]l bfikho^f^gm h_ Zgma^efbgmb\ mk^Zmf^gm hiihkmngbmb^l) Oh bgo^lmb`Zm^ Zg] \hfiZk^ ma^ Zgma^efbgmb\ ikh_be^l h_ g^p ]kn` \Zg]b]Zm^l Z`Zbglm pabiphkf bg_^\mbhgl' ma^ ?# S[XOY fhnl^ fh]^e bl ab`aer lnbmZ[e^ V,/W) ?XOIN[XOY G, aZm\a bg ma^ lfZee bgm^lmbg^ h_ ma^bk ahlm Zg] fb`kZm^ kZib]er mh ma^ \Z^\nf Zg] \hehg V,0W' pa^k^ ma^r bgoZ]^ ma^ ^ibma^ebnf V,1W Zg] ng]^k`h Z ablmhmkhib\ iaZl^ pbma mph fhneml eZlmbg` l^o^kZe ]Zrl #]nkZmbhg ]^i^g]l hg ma^ iZkmb\neZk li^\b^l Zg] blheZm^$) Oa^g' eZkoZ^ fb`kZm^ mh ma^ lnk_Z\^ h_ ma^ ^ibma^ebnf ^qmkn]bg` ma^bk \Zn]Ze ^g]l _k^^er bgmh ma^ enf^g h_ ma^ bgm^lmbg^ #_nkma^k ]^o^ehi^] eZkoZ^ hk _k^^ eZkoZ^$ V,1W) Dg `^g^kZe Zgma^efbgmb\l aZo^ [^^g k^ih km^] mh [^ e^ll ^__^\mbo^ Z`Zbglm ablmhmkhib\ eZkoZ^' pab\a fb`am [^ Zmmkb[nm^] mh ma^ ihhk Z\\^llb[bebmr h_ ]kn`l mh ma^l^ eZkoZ^ pbmabg ma^ mblln^ V,-W) Dg hk]^k mh ^ebfbgZm^ iZkZlbm^l nlbg` Z lbg`e^ ]hl^ hk Zm e^Zlm Z lbg`e^ mk^Zmf^gm [eh\d' bm bl ]^lbkZ[e^ mh ^oZenZm^ ]kn` \Zg]b]Zm^l ghm hger Z`Zbglm fZmnk^ Z]nem phkfl [nm Zelh Z`Zbglm ablmhmkhib\ eZkoZ^ Zg] _nkma^k ]^o^ehi^] bffZmnk^ lmZ`^l) Nbg\^ ]nkZmbhg h_ ]^o^ehif^gm Zg] mbf^liZg h_ bg_^\mbhg ]^i^g] hg [hma' ma^ ahlm lmkZbg V,2W Zg] pabiphkf blheZm^ V,3W' Z ]^mZbe^] \aZkZ\m^kblZmbhg h_ ma^ k^li^\mbo^ ahlm(iZkZlbm^ k^eZmbhglabi bl ^ll^gmbZe) Oanl' eh\ZeblZmbhg h_ eZkoZ^ bg ma^ \hnkl^ h_ ma^ ik^iZm^gm i^kbh] Zg] hgl^m h_ iZm^g\r h_ ma^ bg_^\mbhg aZo^ mh [^ ZgZerl^] \Zk^_neer [^_hk^ OT \O\U ZllZrl Z`Zbglm li^\b_b\ lmZ`^l h_ ?) S[XOY \Zg [^ \hg]n\m^] f^Zgbg`_neer pbma ma^ k^li^\mbo^ blheZm^)

,/2 1NGVZKX *

Oa^ \r\ehh\mZ]^ilbi^imb]^l V,4W Zg] ma^ Zfbghia^greZfb]bg^l V-+W Zk^ ikhfblbg` Zgma^efbgmb\ \eZll^l _hk _nkma^k ]^o^ehif^gm h_ [khZ](li^\mknf ]kn`l mh mk^Zm bgm^lmbgZe g^fZmh]^ bg_^\mbhgl) Oa^ l^fb(lrgma^mb\ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^ aZl [^^g lahpg mh aZo^ Zg Zefhlm \hfie^m^ ^__b\Z\r Z`Zbglm bffZmnk^ Zg] fZmnk^ lmZ`^l h_ ?# \[RVOY bg ]h`l V-,W Zg] ?# S[XOY bg fb\^ V--'-.W pabe^ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e Zg] mkb[^g]bfb]bg^ lahp^] hger ehp mh fh]^kZm^ ^__b\Z\r Z`Zbglm ?# S[XOY bg fb\^ V-/W Zg] ?# ZXOINO[XG bg anfZgl V-0(-2W) =hma ]kn` \eZll^l aZo^ \hfie^m^er ]b__^k^gm mZk`^m fhe^\ne^l) Dm bl \e^Zk maZm ma^ Zfbghia^greZfb]bg^l Zk^ Z`hgblml h_ <>aMl Zg] aZo^ Z o^kr lbfbeZk fh]^ h_ Z\mbhg Zl e^oZfblhe^ V-3'-4W pa^k^Zl l^o^kZe mZk`^ml aZo^ [^^g ln``^lm^] _hk ma^ \r\ehh\mZ]^ilbi^imb]^l pbma ma^ ohemZ`^(`Zm^]' \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e NGJ(, Zl fhlm bfihkmZgm \Zg]b]Zm^ V,4'.+'.,W) Chp^o^k' ma^ B(ikhm^bg \hnie^] k^\^imhk G

Zg] bhghmkhib\ B<=< < k^\^imhkl V..'./W fb`am Zelh \hgmkb[nm^ mh lnl\^imb[bebmr mh \r\ehh\mZ]^ilbi^imb]^l) Oa^k^_hk^' ma^ ik^l^gm lmn]r bgo^lmb`Zm^] Zg] \hfiZk^] ma^ OT \O\U Zgma^efbgmb\ ikhi^kmb^l h_ ma^ l^fb(lrgma^mb\ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^' bml iZk^gmZe gZmnkZe _^kf^gmZmbhg ikh]n\m KA,+--< Zg] ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]

,/3 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

-&, @ObS`WOZa O\R [SbV]Ra

3ZNOIGR YZGZKSKTZ Zk^' Beh[Ze ?kn` ?bl\ho^kr'

2X[MY Zk^ hfiZgr Gbfbm^] #Ub[h' K^hie^"l M^in[eb\ h_ >abgZ$) ngmbe _nkma^k nl^) Dg]bob]nZe ]kn` \hg\^gmkZmbhgl p^k^ ik^iZk^] l^iZkZm^er Zl ]bli^klbhgl bg >k^fhiahk @G #=

/TOSGRY GTJ VGXGYOZKY A^fZe^ NKA bg[k^] fb\^ h_ ma^ lmkZbg >02=G*,+ N\NgJeZCl] #>02=G*,+$ p^k^ ink\aZl^] _khf CZkeZg PF Gbfbm^]' Zm _hnk p^^dl h_ Z`^) Oa^r p^k^ ahnl^] bg HZ\khehg Ä \Z`^l ng]^k ^gobkhgf^gmZeer \hgmkhee^] \hg]bmbhgl Zg] d^im bg `khnil h_ _bo^ ZgbfZel nge^ll hma^kpbl^ bg]b\Zm^]) RZm^k Zg] Ngb__ Ä kh]^gm _hh] i^ee^ml p^k^ ZoZbeZ[e^ GJ ROHOZ[S ) Hb\^ p^k^ Zeehp^] mh Z\\ebfZm^ _hk ^qZ\mer l^o^g ]Zrl [^_hk^ lmZkmbg` Zgr ^qi^kbf^gml) Oa^ ?# S[XOY blheZm^ pZl dbg]er ikhob]^] [r C^bgs H^aeahkg #?{ll^e]hk_' B^kfZgr$) < ]^mZbe^] ablmhkr k^`Zk]bg` blheZmbhg Zg] iZllZ`^ bl ghm ZoZbeZ[e^) Hb\^ p^k^ hkZeer bg_^\m^] pbma Z `ZoZ`^ nlbg` +)- fe _k^la mZi pZm^k pbma -++ ^``l \hgmZbgbg` _neer ]^o^ehi^] G, h_ ?# S[XOY ) Hnkbg^ _Z^\^l p^k^ \hee^\m^] hg ]Zrl /4' 01 Zg] 1. V#O#! ^ nmaZgZlbZ pZl i^k_hkf^] [r \Zk[hg ]bhqb]^ ln__h\Zmbhg) DlheZmbhg h_ ma^ ^``l pZl i^k_hkf^] Zl ]^l\kb[^] eZm^k hg) Oa^ ]^o^ehif^gm h_ G, bg ma^ ^``l pZl i^k_hkf^] bg lm^g]^k ]bla^l bg Zg bg\n[Zmhk Zm -2 |> Zg] 40 anfb]bmr _hk ZiikhqbfZm^er ^b`am p^^dl) Kkh`k^ll h_ ^f[krhgZmbhg pZl \hgmkhee^] p^^der) <_m^k ]^o^ehif^gm h_ G, bg 94+ h_ ma^ ^``l pZl \hfie^m^]' ^``l p^k^ lmhk^] Zm / |> ngmbe _nkma^k nlZ`^ _hk Z fZqbfnf h_ lbq fhgmal) =^_hk^ bg_^\mbhg h_ fb\^' ma^ ^`` lnli^glbhg pZl pZla^] pbma _k^la mZi pZm^k Zm khhf m^fi^kZmnk^)

,/4 1NGVZKX *

2KZKXSOTGZOUT UL ZNK VKXOUJY UL VXKVGZKTI_ GTJ VGZKTI_ Oh Zll^ll ma^ ]nkZmbhg h_ ik^iZm^gm i^kbh]' m^g fb\^ p^k^ bg_^\m^]) NmZkmbg` _khf ]Zr 2 V#O)' Zee m^g fb\^ p^k^ ahnl^] hg `kb]l mh \hee^\m _Z^\^l _hk -/ a hg\^ Z p^^d) ?nkbg` ma^l^ i^kbh]l' ma^ [hmmhf h_ ma^ \Z`^ pZl \ho^k^] pbma .++ fe mZi pZm^k) AZ^\^l Zg] pZm^k p^k^ \hee^\m^] bg Z , e [^Zd^k Zg] ahfh`^gbl^] pbma Z aZg](a^e] [e^g]^k ) Plbg` Z phh]^g liZmneZ' _bg^ \hfihg^gml h_ ma^ _Z^\^l p^k^ l^iZkZm^] _khf k^fZbgbg` ]^[kbl [r _bemkZmbhg makhn`a Z -++ f lb^o^ Zg] \hee^\m^] bg Z \e^Zg , e [^Zd^k) Oa^ k^lb]n^l p^k^ kbgl^] pbma mZi pZm^k ngmbe ma^ _bemkZm^ k^Z\a^] Z ohenf^ h_ 1++ fe) <_m^k l^]bf^gmZmbhg _hk , a' ma^ lni^kgZmZgml #ZiikhqbfZm^er 0++ fe$ p^k^ k^fho^]) Oa^ l^]bf^gm pZl \^gmkb_n`^] Zm -+++ !` Zg] khhf m^fi^kZmnk^ _hk ,+ fbg) Oa^ i^ee^m pZl k^lnli^g]^] bg -++ fe mZi pZm^k Zg] \^gmkb_n`^] ng]^k ma^ lZf^ \hg]bmbhgl) <_m^k Zghma^k pZlabg` lm^i' ma^ i^ee^m pZl k^lnli^g]^] bg -++ fe lZmnkZm^] lh]bnf \aehkb]^ lhenmbhg) Oa^g' lZfie^l p^k^ \^gmkb_n`^] Zm -+++ !` Zg] khhf m^fi^kZmnk^ _hk 0 fbg' ma^ mhi -0 fe p^k^ _bee^] bgmh Z .++(fe [^Zd^k Zg] --0 fe mZi pZm^k p^k^ Z]]^]) <_m^k Zm e^Zlm - a h_ l^]bf^gmZmbhg ma^ lni^kgZmZgm pZl ]^\Zgm^] Zg] ma^ l^]bf^gm pZl pZla^] bg mZi pZm^k Zghma^k _hnk mbf^l) <_m^k ]^\Zgmbg` ma^ lni^kgZmZgm' ma^ l^]bf^gm #ZiikhqbfZm^er -+ fe$ pZl ^qZfbg^] _hk ma^ ik^l^g\^ h_ ^``l) @qZfbgZmbhg h_ _Z^\^l pZl \hgmbgn^] ngmbe mak^^ \hgl^\nmbo^ lZfie^l p^k^ _hng] mh [^ g^`Zmbo^) Oak^^ bg]^i^g]^gm ^qi^kbf^gml pbma m^g fb\^ ^Z\a p^k^ i^k_hkf^])

AGXOGZOUT OT KMM U[ZV[Z OT ZNK IU[XYK UL VGZKTI_ UL ZNK OTLKIZOUT Oh ]^m^kfbg^ ma^ oZkbZmbhg bg ^`` hnminm bg ma^ \hnkl^ h_ iZm^g\r h_ ma^ bg_^\mbhg' Z _Z^\Ze ^`` \hngm f^mah] pZl Z]Zim^] _khf Nmhee V.0W) Dg [kb^_' m^g fb\^ p^k^ bg_^\m^]) Jger ZgbfZel' ihlbmbo^ _hk ^``l bg ma^bk _Z^\^l hg ]Zr .0 V#O )' p^k^ bg\en]^] bg ma^ lmn]r) NmZkmbg` _khf ]Zr .0 V#O#' fb\^ p^k^ ahnl^] bg]bob]nZeer hg `kb]l bg HZ\khehg Ä \Z`^l mh \hee^\m bg]bob]nZe _Z^\^l _hk ,- a i^kbh]l hg\^ Z p^^d) AZ^\Ze lZfie^l #+)0 `$ p^k^ p^b`a^] _khf ^Z\a fhnl^' 2)+ fe pZm^k p^k^ Z]]^] Zg] bg\n[Zm^] _hk ,0 fbg) AZ^\^l p^k^ khn`aer fZ\^kZm^] pbma Z phh]^g liZmneZ _heehp^] [r Zg ^qm^glbo^ ahfh`^gblZmbhg nlbg` Z fZ`g^mb\ lmbkk^k Zm ehp li^^] ngmbe lZfie^l p^k^ ZgZerl^]) Ahk ^Z\a lZfie^' mak^^ 20 e Zebjnhml p^k^ ibi^mm^] hg fb\khl\hi^ leb]^l Zg] ^``l p^k^ \hngm^]) Oh h[mZbg ma^ gnf[^k h_ ^``l i^k `kZf #^i`$ _Z^\^l' ma^ Zkbmaf^mb\ f^Zg h_ ma^ mak^^ \hngml pZl fnembieb^] [r -++ mh \Ze\neZm^ ma^ gnf[^k ^i` _Z^\^l) AZ^\^l p^k^ ZgZerl^] ngmbe ,0 p^^dl V#O)' lbg\^ lmZmnl h_ iZm^g\r h_ ma^ bg_^\mbhg [^\Zf^ jnbm^ oZkbZ[e^ Z_m^kpZk]l)

,0+ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

?OSK IU[XYK UL RUIGROYGZOUT UL RGX\GK OT ZNK IU[XYK UL VXKVGZKTZ VKXOUJ Oh ZgZerl^ ma^ mbf^ \hnkl^ h_ ma^ eh\ZeblZmbhg h_ eZkoZ^ ]nkbg` ik^iZm^gm i^kbh] ma^ _heehpbg` ^qi^kbf^gm pZl Z]Zim^] _khf KZg^lZk V.1W) Ahk mabl ^qi^kbf^gm ,-+ fb\^ p^k^ bg_^\m^]) ?nkbg` ma^ _bklm /+ ]Zrl V#O#! mak^^ fb\^ p^k^ ^nmaZgbl^] ]Zber Zg] ma^bk ]nh]^gZ' \Z^\Z Zg] \hehgl p^k^ k^fho^] Zg] liebm hi^g) Oa^ enfbgZe \hgm^gm pZl k^fho^] Zg] bgli^\m^] _hk Zgr lmZ`^l h_ ?# S[XOY ) Oa^g' ma^ fn\hlZ h_ ma^ `nml pZl ^qZfbg^] _hk ma^ ik^l^g\^ h_ phkfl ^qmkn]bg` bgmh ma^ enf^g h_ ma^ `nml) AbgZeer' ]nh]^gZ' \Z^\Z Zg] \hehgl p^k^ \nm bgmh lfZee ljnZk^l Zg] l^iZkZm^er bg\n[Zm^] bg +)30 iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg Zm .2 |> _hk -/ a) =r \Zk^_neer l\kZibg` ma^ fn\hlZ ma^ ablmhmkhib\ eZkoZ^ [^\Zf^ oblb[e^ nlbg` Z ]bll^\mbg` fb\khl\hi^) N^o^g fb\^' bg pab\a ghm Z lbg`e^ lmZ`^ h_ ?# S[XOY pZl _hng]' p^k^ ^q\en]^] _khf ma^ lmn]r)

4KSGRK$SGRK XGZOU OT ZNK IU[XYK UL OTLKIZOUT Jg ]Zr .0 V#O#! _Z^\Ze ^qZfbgZmbhgl p^k^ i^k_hkf^] _hk ^Z\a h_ ma^ 1+ bg_^\m^] fb\^ bg]bob]nZeer mh \hg_bkf iZm^g\r h_ ma^ bg_^\mbhg) Jger ZgbfZel _hng] ihlbmbo^ _hk ^``l bg ma^bk _Z^\^l p^k^ bg\en]^] bg ma^ lmn]r) R^^der' lmZkmbg` _khf ]Zr .0 ngmbe ]Zr ,0- V#O#! mak^^ fb\^ p^k^ ^nmaZgbl^] Zg] ]bll^\m^]) A^fZe^ Zg] fZe^ pabiphkfl bg \Z^\nf Zg] \hehg p^k^ \hngm^]) Oph bg]^i^g]^gm ^qi^kbf^gml pbma 1+ fb\^ bg ^Z\a ^qi^kbf^gm p^k^ i^k_hkf^])

7T \OZXU KSHX_UTGZOUT UL ?# S[XOY KMMY Oa^ ^f[krhgZmbhg h_ ^``l pZl ZgZerl^] Zg] \hfiZk^] ng]^k l^o^kZe ]b__^k^gm \hg]bmbhgl) Ak^laer blheZm^] Zg] inkb_b^] ^``l p^k^ lnli^g]^] bg #b$ +)0 _hkfZe]^ar]^ bg iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg' #bb$ iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg hk #bbb$ mZi pZm^k Zg] mkZgl_^kk^] bgmh /+ fe lm^g]^k ]bla^l #l^^ V.2W$ mh \hfiZk^ ma^ kZm^ Zg] li^^] h_ ]^o^ehif^gm) Oa^ ikh`k^ll h_ ^f[krhgZmbhg pZl Zll^ll^] p^^der [r fb\khl\hib\ ZgZerlbl h_ mak^^ ,+ e Zebjnhml) @``l p^k^ \hngm^] Zg] \Zm^`hkbl^] Zl #b$ ng^f[krhgZm^]' #bb$ iZkmbZeer ^f[krhgZm^]' #bbb$ _neer ^f[krhgZm^] hk #bo$ ]^`kZ]^]) Oa^ eZmm^k \Zm^`hkr pZl \ahl^g Z\\hk]bg` mh ma^ _heehpbg` \kbm^kbZ5 Z$ o^lb\neZk Zii^ZkZg\^ h_ ngl^`f^gm^] ^``l hk [$ ]^_hkf^] eZkoZe lmkn\mnk^l pbmabg ma^ ^``l) ! Ankma^kfhk^' bg\n[Zmbhg m^fi^kZmnk^l h_ / |>' ,4 |>' -2 |> Zg] .2 |> Zl p^ee Zl ma^ bg_en^g\^ h_ ma^ ik^l^g\^ h_ Zgmb[bhmb\ # O#K# ,+ å`*fe lblhfr\bg ienl , å`*fe \ehmkbfZshe^$' k^eZmbo^ anfb]bmr #20 ' 30 Zg] 40 $ Zg] eb`am \hg]bmbhgl #eb`am o^klnl gh eb`am$ p^k^ ^oZenZm^] bg mZi pZm^k nlbg` ma^ lZf^ f^mah] )

,0, 1NGVZKX *

AbgZeer' ma^ bg_en^g\^ h_ lmhkZ`^ Zm / |> Z_m^k _nee ^f[krhgZmbhg h_ ^``l pZl \hfiZk^] mh lmhkZ`^ Zm -2 |> mh ]^m^kfbg^ ma^ [^lm lmhkZ`^ \hg]bmbhg) <_m^k ^f[krhgZmbhg Zm -2 |>' ^``l p^k^ lmhk^] Zm -2 |> hk Zm / |> _hk 2+ ]Zrl) Ahk ^Z\a bg\n[Zmbhg m^fi^kZmnk^' 0 fb\^ p^k^ bg_^\m^]) Jg ]Zr /0 V#O#! fb\^ p^k^ ^nmaZgbl^] Zg] phkf \hngml p^k^ ]^m^kfbg^])

7T \O\U KLLOIGI_ GMGOTYZ ?# S[XOY OT SOIK Dg -/ \hgl^\nmbo^ ^qi^kbf^gmZe [eh\dl' 100 fb\^ p^k^ kZg]hfbl^] bgmh ,.- `khnil' ^Z\a \hglblmbg` h_ _bo^ ZgbfZel) Jg^ `khni h_ _bo^ fb\^ pZl nl^] _hk ^Z\a ]hlZ`^ Zg] _hk ^Z\a Z]fbgblmkZmbhg khnm^ m^lm^]) Dg ^Z\a [eh\d' _bo^ bg_^\m^] fb\^ l^ko^] Zl ngmk^Zm^] \hgmkhe Zg] k^\^bo^] ma^ o^ab\e^ hger)

7T \O\U KLLOIGI_ GMGOTYZ SGZ[XK GJ[RZ YZGMKY UL ?# S[XOY Jg ]Zr /- V#O#! Z _Z^\Ze ^qZfbgZmbhg pZl i^k_hkf^] _hk ^Z\a fhnl^ mh \hg_bkf iZm^g\r h_ ma^ bg_^\mbhg) Jger ZgbfZel ihlbmbo^ _hk ?# S[XOY ^``l bg ma^bk _Z^\^l p^k^ bg\en]^] bg ma^ lmn]r) =Zl^] hg ma^ bg]bob]nZe [h]r p^b`am hg ]Zr /0 V#O#! ^qZ\m ]hlZ`^l p^k^ \Ze\neZm^]) Dg \Zl^ h_ fnembie^ ]hl^ k^`bf^gl' mak^^ ]hl^l h_ ma^ k^li^\mbo^ ]kn` p^k^ Z]fbgblm^k^] hkZeer' bgmkZi^kbmhg^Zeer hk ln[\nmZg^hnler #gn\aZe _he]$ hg ]Zrl /1(/3 V#O# ?hlZ`^l nl^] Zk^ lnffZkbl^] bg OZ[) 0( ,) Ahk lbg`e^ ]hl^l' 0+' 20' ,++' ,0+' -++' -0+' .++ hk 0++ f`*d` KA,+--< p^k^ Z]fbgblm^k^] hg ]Zr /3 V#O# Jg ]Zr /4 V#O#! fb\^ p^k^ ^nmaZgbl^]) Nn[l^jn^gmer' g^\khilr pZl i^k_hkf^] Zg] phkfl bg \hehgl Zg] \Z^\Z p^k^ \hngm^])

GOP& -%)& Nbg`e^ Zg] fnembie^ ]kn` ]hlZ`^l ^oZenZm^] OT \O\U Z`Zbglm fZmnk^ Z]neml h_ ! ?# S[XOY ' \eZllb_b^] [r khnm^ h_ Z]fbgblmkZmbhg

+;>154 (95"75 #!( $!# %!( (!# )!( $# $( %# %( (# )( $## $(# %## %(# &## '## (##

/-$#%%* "9 13%. $ $ $ $ $ $ $ $ !9 13%. $ $ $ $ $ $ $ $ "9 46&'65%0)164 $ $ $ $ $ $ $ $ "9 -053%2)3-510)%. $ $ $ $ $ $ $ $ ,9;34<>634 "9 13%. $ $ $ $ $ $ $ $ "9 46&'65%0)164 $ $ $ $ $ $ $ $ "9 -053%2)3-510)%. $ $ $ $ $ $ $ $ *9631:?48 "9 13%. $ "9 46&'65%0)164 "9 -053%2)3-510)%. 3*.+ "9 13%. $ $ $ $ $ $ "9 46&'65%0)164 $ $ "9 -053%2)3-510)%. $ $ $ $ $ 0=624:369636:4 "9 13%. $ $ $ $ $ $ "9 46&'65%0)164 $ $ "9 -053%2)3-510)%. $ $ $ $ $ ;$< -0(-'%5)( 5,%5 5,) 3)42)'5-7) (36+ 8%4 )7%.6%5)( -0 5,) +-7)0 (14) 64-0+ 5,) -0(-'%5)( 3165) 1* %(/-0-453%5-10

,0- 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

7T \O\U KLLOIGI_ GMGOTYZ RGX\GR GTJ OSSGZ[XK GJ[RZ YZGMKY UL ?# S[XOY =Zl^] hg ma^ iZkZlbmheh`b\Ze \aZkZ\m^kblZmbhg # ]nkZmbhg h_ ik^iZm^gm i^kbh] Zg] mbf^( ]^i^g]^gm eh\ZeblZmbhg h_ eZkoZ^ ]nkbg` i^kbh] h_ ik^iZm^g\r$' ma^ OT \O\U ^__b\Z\r h_ KA,+--< pZl Zelh bgo^lmb`Zm^] Z`Zbglm eZkoZe Zg] bffZmnk^ Z]nem lmZ`^l h_ ?# S[XOY ) <\\hk]bg` mh ma^ mbf^ \hnkl^ h_ eh\ZeblZmbhg h_ ]^o^ehif^gmZe lmZ`^l bg ma^ ik^l^gm lmn]r Zg] ma^ ZgZerlbl hg ma^ fhnembg` iZmm^kg bg ?# S[XOY V.1W' ma^ _heehpbg` mbf^ ihbgml _hk ]kn` Z]fbgblmkZmbhg p^k^ \ahl^g5 Dg]bob]nZe [h]r p^b`am pZl ]^m^kfbg^] hg ma^ ]Zr h_ bg_^\mbhg _hk G,' hg ]Zr ,, V#O# _hk G- Zg] hg ]Zr -0 V#O# _hk _nkma^k ]^o^ehi^] lmZ`^l) KA,+--< ]hlZ`^l h_ ,+' ,++' -0+' Zg] 0++ f`*d` hk ,)+' ,+' 0+ Zg] ,++ f`*d` p^k^ Z]fbgblm^k^] hg ]Zr . V#O# hk hg ]Zrl ,(. V#O# mh mZk`^m G,) Ahk ma^ ^oZenZmbhg h_ ^__b\Z\r Z`Zbglm ma^ ablmhmkhib\ G-' mk^Zmf^gml p^k^ \Zkkb^] hnm pbma KA,+--< ]hlZ`^l h_ ,+' ,++' -0+' Zg] 0++ f`*d` hk ,)+' ,+' 0+ Zg] ,++ f`*d` hg ]Zr ,/ V#O# hk hg ]Zrl ,-(,/ V#O#! k^li^\mbo^er) Nbg\^ ma^ _heehpbg` fhneml h_ fZe^l Zg] _^fZe^l Zk^ e^ll lrg\akhghnl V.1W' mk^Zmf^gml p^k^ ]bk^\m^] Z`Zbglm _nkma^k ]^o^ehi^] bffZmnk^ lmZ`^l bg `^g^kZe) Ok^Zmf^gml pbma ,)+' ,+' 0+ Zg] ,++ f`*d` KA,+--< p^k^ i^k_hkf^] hg mak^^ \hgl^\nmbo^ ]Zrl #-1(-3 V#O)$ Zg] mk^Zmf^gml pbma ,+' ,++' -0+' Zg] 0++ f`*d` KA,+--< hger hg ]Zr -3 V#O# Dg]^i^g]^gmer h_ ma^ mZk`^m^] lmZ`^ ^nmaZgZlbZ h_ fb\^ Zg] phkf \hngml p^k^ i^k_hkf^] hg ]Zr /4 V#O#

1GRI[RGZOUT UL JUYK"XKYVUTYK I[X\KY GTJ YZGZOYZOIGR GTGR_YOY Ahk iZkZlbmheh`b\Ze \aZkZ\m^kblZmbhg h_ ma^ ?# S[XOY blheZm^ nl^] bg >02=G*,+ fb\^' ]^l\kbimbo^ lmZmblmb\l p^k^ i^k_hkf^] nlbg` BkZiaKZ] Kkblf 0)+.) ?b__^k^g\^l bg phkf \hngml [^mp^^g ]b__^k^gm p^^dl h_ bg_^\mbhg Zg] bg l^q kZmbh p^k^ ]^m^kfbg^] [r Z Jg^ RZr

_bo^ fb\^ pZl iehmm^] Z`Zbglm ma^ eh` ,+ h_ ma^ ]kn` ]hlZ`^l) @__b\Z\b^l p^k^ l^m mh s^kh b_ f^Zg h_ ma^ phkf \hngml pZl ab`a^k maZg ma^ f^Zg h_ ma^ \hkk^lihg]bg` \hgmkhe `khni) Ankma^kfhk^' ma^ \hkk^lihg]bg` N@H oZen^l h_ ma^ Z__^\m^] `khnil lmZkm _khf + #Zee _b`nk^l lahpbg` ]hl^(k^lihgl^ \nko^l$) Ahnk(iZkZf^m^k(eh`blmb\ \nko^l p^k^ _bmm^] nlbg` BkZiaKZ] Kkblf 0)+. V.3W) Oa^ mhi pZl \hglmkZbg^] mh oZen^l [^mp^^g + Zg] ,++ ) Oa^ gh(]kn` (/ \hgmkhel p^k^ l^m mh ,+ f`*d` mh Zeehp eh` ,+ mkZgl_hkfZmbhg h_ ]hlZ`^l) >Ze\neZm^] @? 0+ Zg]

@? 40 oZen^l p^k^ \hfiZk^] nlbg` ma^ ^qmkZ lnf h_ ljnZk^l A m^lm) D_ fnembie^ m^lml p^k^

,0. 1NGVZKX * i^k_hkf^]' <(oZen^l p^k^ \hkk^\m^] nlbg` ma^ =hg_^kkhgb(Chef^l ikh\^]nk^) Oa^ Z[lhenm^ gnf[^k h_ k^\ho^k^] fZmnk^ Z]nem phkfl Z_m^k mk^Zmf^gm Z`Zbglm eZkoZe Zg] bffZmnk^ Z]nem lmZ`^l pZl \hfiZk^] mh ma^ gnf[^k h_ phkfl blheZm^] _khf ma^ g^`Zmbo^ \hgmkhel [r nlbg` ma^ ghg(iZkZf^mkb\ FknldZe(RZeebl m^lm pbma ?nggâl VUYZ NUI m^lm _hk b]^gmb_b\Zmbhg h_ lb`gb_b\Zgm ]b__^k^g\^l [^mp^^g bg]bob]nZe `khnil)

,0/ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

-&- ESacZba

?OSK IU[XYK UL ?# S[XOY JK\KRUVSKTZ OT 1*,08$&% SOIK

2KZGORKJ GTGR_YOY UT KMM YNKJJOTM Ibg^ hnm h_ m^g fb\^ p^k^ _hng] ihlbmbo^ _hk ^``l bg ma^bk _Z^\^l hg ]Zr .0 V#O) Oa^k^_hk^' hger Z lbg`e^ fhnl^ pZl ^q\en]^] _khf ma^ lmn]r) Ankma^kfhk^' hg^ bg]bob]nZe fhnl^ ]b^] hg ]Zr 12 V#O) Zg] pZl hger bg\en]^] bg ma^ lmZmblmb\l ngmbe ]Zr 1. V#O# QZkbZmbhg bg ^`` la^]]bg` bg ma^ \hnkl^ h_ iZm^g\r h_ ma^ bg_^\mbhg bl lnffZkbl^] bg Ab`) 0( ,) Nmkhg` oZkbZmbhg bg bg]bob]nZe ^`` \hngml pZl h[l^ko^]' bg]b\Zm^] [r ma^ k^eZmbo^er eZk`^ lmZg]Zk] ]^obZmbhgl #Ab`) 0( ,$) Dg `^g^kZe' ma^ f^Zg ^i` bg\k^Zl^] ]nkbg` ma^ _bklm mak^^ p^^dl h_ iZm^g\r h_ ma^ bg_^\mbhg lmZkmbg` pbma Z f^Zg ^i` h_ -4,4 É ,,3- #kZg`^ 3++(01++$ Zm ]Zr .0 V#O# Oa^ i^Zd bg ^`` hnminm pZl h[l^ko^] bg p^^d 3 V#O# #^i` 8 ,--++ É .3,.' kZg`^ /-++(,43++$) NmZkmbg` _khf p^^d 4 V#O#' Z `kZ]nZe k^]n\mbhg h_ ma^ Zo^kZ`^ ^`` \hngm pZl h[l^ko^]) Dg p^^d ,/ V#O# ma^ _bklm fhnl^ pZl _hng] mh [^ g^`Zmbo^ _hk ^``l bg bml _Z^\^l) Dg Zghma^k mph fb\^ iZm^g\r h_ ma^ bg_^\mbhg \^Zl^] bg p^^d ,0 V#O# Ahk ma^ k^fZbgbg` _bo^ fb\^ ma^ f^Zg #É N?$ h_ ^i` _Z^\^l pZl \Ze\neZm^] mh [^ ,,-+ É ,,,+)0 #kZg`^ -++(.1++$ hg p^^d ,0 V#O#' [^bg` ma^ _bgZe p^^d h_ mabl ZgZerlbl)

,00 1NGVZKX *

9WU& -%)&

8UIGROYGZOUT UL JK\KRUVSKTZGR YZGMKY ZNXU[MNU[Z OTLKIZOUT Oa^ ZgZerlbl h_ ma^ mbf^ \hnkl^ h_ ma^ fb`kZmbhg h_ ?# S[XOY lmZ`^l ]nkbg` ma^ i^kbh] h_ ik^iZm^g\r k^o^Ze^] ]blmbg\m iaZl^l h_ eh\ZeblZmbhg) Ab`) 0( - lnffZkbl^l ma^ mk^g] bg Z[lhenm^ gnf[^kl h_ k^\ho^k^] lmZ`^l bg ma^ \hnkl^ h_ ma^ ik^iZm^gm i^kbh]) Nniie^f^gmZkr OZ[) 0( . lahpl ma^ bg]bob]nZe \hngml ]bob]^] [r ]nh]^gnf' \Z^\nf' \hehg Zg] enfbgZe ]^[kbl) Jg ]Zrl ,(/ V#O) Z lfZee gnf[^k #-)3 É ,)4' f^Zg É N?$ h_ ^f[krhgZm^] ^``l pZl k^\ho^k^] _khf ma^ bgm^lmbgZe ]^[kbl h_ ]nh]^gnf' \Z^\nf Zg] \hehg) <_m^k ]Zr 0 V#O# gh ^f[krhgZm^] ^``l p^k^ _hng] bg ma^ `Zlmkhbgm^lmbgZe mkZ\m) Ak^^ eZkoZ^ p^k^ b]^gmb_b^] bg ma^ ]^[kbl h_ `nml Zelh _hk Z o^kr ebfbm^] i^kbh] ]nkbg` ma^ _bklm ]Zrl Z_m^k bg_^\mbhg) Ra^k^Zl 4)+ É 1)- _k^^ eZkoZ^ p^k^ k^\ho^k^] [^mp^^g ]Zr , Zg] ]Zr 0 V#O) hger hg^ lZfie^ hg ]Zr 3 pZl _hng] ihlbmbo^ _hk mph _k^^ eZkoZ^) Chp^o^k' lmZkmbg` _khf ]Zr -2 Zg bg\k^Zlbg` gnf[^k h_ bffZmnk^ Zg] fZmnk^ Z]nem phkfl bg ma^ ]^[kbl pZl \hngm^] #l^^ Nniie^f^gmZkr OZ[) 0( .$) Cblmhmkhib\ eZkoZ^ p^k^ k^\ho^k^] Zefhlm makhn`ahnm ma^ pahe^ ^oZenZmbhg i^kbh]) Chp^o^k' ]nkbg` ma^ i^kbh] h_ ik^iZm^g\r mph k^eZmbo^ fZqbfZ bg ablmhmkhib\ eZkoZe \hngml p^k^ h[l^ko^]) < ab`a gnf[^k h_ ablmhmkhib\ eZkoZ^ pZl ]^m^\m^] hg ]Zrl , Zg] - V#O# #/0)3 É /)0$' pabe^ hger Z lfZee gnf[^k pZl k^\ho^k^] [^mp^^g ]Zrl . Zg] ,- V#O# #,+). É /),$) NmZkmbg` _khf ]Zr ,. ma^ gnf[^k lm^Z]ber bg\k^Zl^] ngmbe ]Zr ,4 V#O#! pa^k^ 0+). É ,2)/ eZkoZ^ p^k^ \hngm^] #l^^ Nniie^f^gmZkr OZ[) 0( .$) Akhf ]Zr -+ V#O# hg' ma^ gnf[^k h_ ablmhmkhib\ eZkoZ^ ]^\k^Zl^] Z`Zbg Zg] _bgZeer' lmZkmbg` _khf ]Zr -/ V#O#! ma^ fZchkbmr h_ ma^ `nml pZl _hng] mh [^ g^`Zmbo^) Ankma^k ]^o^ehi^] lmZ`^l p^k^ ghm _hng] [^_hk^ ]Zr -, V#O# Oa^ gnf[^k h_ ma^l^ lmZ`^l ma^g

,01 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY bg\k^Zl^] ngmbe ]Zr -/ Zg] k^fZbg^] lmZ[e^ #/-)1 É ,.)4$ ngmbe ma^ ^g] h_ ma^ ^oZenZmbhg i^kbh] #l^^ Ab`) 0( -$)

9WU& -%*&

Kk^l^gm^] bl ma^ h\\nkk^g\^ h_ G, bg ma^ enfbgZe \hgm^gm h_ ma^ `nml #_k^^ lmZ`^l$' h_ ablmhmkhib\ _bklm' G- Zg] G. #ablmhmkhib\ lmZ`^l$ Zg] h_ G. Zg] G/ Zl p^ee Zl bffZmnk^ Zg] fZmnk^ Z]neml ZmmZ\a^] mh ma^ ^ibma^ebnf pabe^ ^qmkn]bg` ma^bk ihlm^kbhk iZkml bgmh ma^ enf^g h_ ma^ `nml #^qmkn]bg` lmZ`^l$ [^mp^^g ]Zrl , Zg] ., V#O# =Zl^] hg ]bll^\mbhg h_ mak^^ fb\^ i^k mbf^ ihbgm' ma^ `kZia lahpl mak^^ ]ZmZ ihbgml _hk ^Z\a lmZ`^ Zg] mbf^ ihbgm) D_ ma^ \hngm pZl _hng] mh [^ s^kh _hk Z li^\b_b\ lmZ`^ bg ^Z\a h_ ma^ mak^^ bg]^i^g]^gm \hngml' ]ZmZ ihbgml Zk^ ghm lahpg)

BUXS IU[TZY GTJ YK^ XGZOU Jg ]Zr .0 V#O#! ,+2*,-+ fb\^ aZk[hnk^] Z iZm^gm bg_^\mbhg #bg_^\mbhg kZm^ h_ 34),2 $) ,. ngbg_^\m^] fb\^ Zg] _hnk fb\^ pab\a aZ] ]b^] bg ma^ \hnkl^ h_ ma^ ^qi^kbf^gm p^k^ ^q\en]^ _khf ma^ ZgZerlbl) Oa^ Z[lhenm^ phkf \hngml i^k bg_^\m^] ahlm Zk^ lnffZkbl^] bg Ab`) 0( .<) H^Zg phkf \hngml p^k^ ghm lb`gb_b\Zgmer ]b__^k^gm _khf mahl^ hg ]Zr .0 V#O) ni mh ]Zr 2+ V#O# #Jg^ RZr

_hng] bg hg^ h_ ma^ g^\khilb^] fb\^) Dg Z]]bmbhg mh ma^ Z[lhenm^ phkf \hngml' Ab`) 0( .= lahpl ma^ k^eZmbo^ l^q ]blmkb[nmbhg h_ ma^ phkfl ]nkbg` ma^ lZf^ ^oZenZmbhg i^kbh]) Oa^ fZe^*_^fZe^ kZmbh pZl ikh`k^llbo^er ld^p^] mhpZk]l fZe^ phkfl) Oa^ kZmbh pZl ,5,)-2 _bo^ p^^dl V#O! ,5+)42 gbg^ p^^dl V#O)' ,5+)01 ,/ p^^dl V#O#! Zg] ,5+),- ,2 p^^dl V#O# NmZkmbg` bg p^^d 4' ma^ fZe^*_^fZe^ kZmbh pZl lb`gb_b\Zgmer ab`a^k maZg hg ]Zr .0 V#O# #Jg^ RZr

9WU& -%+&

,03 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

;VZOSOYKJ IUTJOZOUTY LUX OT \OZXU KSHX_UTGZOUT UL ?# S[XOY KMMY Oa^ bg_en^g\^ h_ ]b__^k^gm f^]bZ hg ma^ kZm^ Zg] li^^] h_ ^f[krhgZmbhg p^k^ \hfiZk^]) Ih lb`gb_b\Zgm ]b__^k^g\^ pZl h[l^ko^] [^mp^^g #b$ +)0 _hkfZe]^ar]^ bg iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg' #bb$ iarlbheh`b\Ze lh]bnf \aehkb]^ lhenmbhg Zg] #bbb$ mZi pZm^k #]ZmZ ghm lahpg$) Oa^k^_hk^' mZi pZm^k pZl nl^] Zl f^]bnf _hk ma^ _heehpbg` ZgZerl^l) Oa^ bg\n[Zmbhg m^fi^kZmnk^ #/ |>' ,4 |>' -2 |> hk .2 |>$ aZ] Zg ^ghkfhnl bfiZ\m hg [hma li^^] Zg] ^f[krhgZmbhg kZm^ # Nniie^f^gmZkr OZ[) 0( /$) Ni^^] h_ ^f[krhgZmbhg lm^Z]ber bg\k^Zl^] pbma m^fi^kZmnk^) Chp^o^k' Zm .2 |> ma^ Z[lhenm^ gnf[^k h_ ]^`^g^kZm^] ^``l pZl Zelh bg\k^Zl^]) <]]bmbo^l ln\a Zl lblhfr\bg ienl \ehmkbfZshe^ hk eb`ambg` \hg]bmbhgl ]b] ghm bg_en^g\^ ^f[krhgZmbhg Zg] p^k^ ma^k^_hk^ g^`e^\m^]) Chp^o^k' k^eZmbo^ a nfb]bmr #20 ' 30 Zg] 40 $ lmkhg`er Z__^\m^] ma^ ehll h_ f^]bnf [r ^oZihkZmbhg Zg] ma^k^_hk^ 40 anfb]bmr pZl \ahl^g _hk khnmbg^ inkihl^l) AbgZeer' ma^ bg_en^g\^ hg lmhkZ`^ m^fi^kZmnk^ hg ^`` bg_^\mbobmr Z_m^k _nee ^f[krhgZmbhg pZl m^lm^]) Hb\^ bg_^\m^] pbma ^``l lmhk^] Zm -2 |> hk Zm / |> _hk Zm e^Zlm 2+ ]Zrl p^k^ g^\khilb^] hg ]Zr /0 V#O# Oa^ bg_^\mbhg e^o^el [^mp^^g [hma `khnil p^k^ ghm _hng] mh ]b__^k lb`gb_b\Zgmer' Zl beenlmkZm^] [r phkf \hngml kZg`bg` [^mp^^g -3 Zg] /0 hk ,- Zg] 04 # <8+)14 nlbg` ma^ HZgg Rabmg^r P m^lm$)

7T \O\U KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GTJ GSOTUVNKT_RGSOJOTKY GMGOTYZ ?# S[XOY Oa^ Zo^kZ`^ gnf[^k h_ phkfl k^\ho^k^] _khf \Z^\nf Zg] \hehg _khf ngmk^Zm^] \hgmkhe fb\^ hg ]Zr /4 pZl ..)22 É ,0)04) Rhkf \hngml Z_m^k mk^Zmf^gm Z`Zbglm ]^o^ehif^gmZe lmZ`^l p^k^ Zelh ]^m^kfbg^] hg ]Zr /4 V#O#! pabe^ _hnk fb\^ ]b^] [^_hk^ ^oZenZmbhg Zg] p^k^' ma^k^_hk^' ghm bg\en]^] bg ma^ lmZmblmb\l) Oa^ ab`a^lm phkf \hngm pZl 3+' pa^k^Zl gh phkfl p^k^ k^\ho^k^] bg mph \Zl^l)

7T \O\U KLLOIGI_ UL GSOTUVNKT_RGSOJOTKY GMGOTYZ SGZ[XK GJ[RZ YZGMKY UL ?# S[XOY Oak^^ hkZe ]hl^l h_ 0++ f`*d` h_ ma^ Zfbghia^greZfb]bg^ Zfb]Zgm^e e^] mh gh lb`gb_b\Zgm k^]n\mbhg h_ ma^ phkf [nk]^g) Nbg\^ mak^^ ab`a \hgl^\nmbo^ ]hl^l h_ Zfb]Zgm^e ]b] ghm k^]n\^ phkf \hngml bg \hfiZkblhg mh ma^ gh(]kn` \hgmkhe' mabl ]^kboZmbo^ pZl ghm _nkma^k ^oZenZm^] bg ma^ ik^l^gm lmn]r) Dg \hgmkZlm mh Zfb]Zgm^e' [hma hkZe Zg] bgmkZi^kbmhg^Ze mk^Zmf^gml pbma ^bma^k mkb[^g]bfb]bg^ hk ]

Ankma^kfhk^' @? 0+ Zg] @? 40 oZen^l pbma 40 \hg_b]^g\^ bgm^koZel Zl p^ee Zl < oZen^l _khf ' \hfiZkblhgl [^mp^^g ma^ ]^kboZmbo^l Zg] = oZen^l Zk^ lnffZkbl^] bg OZ[) 0( -) Oa^ @? 40 h_

,04 1NGVZKX *

mkb[^g]bfb]bg^ pZl _hng] mh [^ ZiikhqbfZm^er ^b`am mbf^l ehp^k maZg ma^ @? 40 h_ ]

_heehpbg` mak^^ hkZe \hgl^\nmbo^ ]hl^l' pa^k^Zl ma^ @? 40 h_ mkb[^g]bfb]bg^ pZl

ZiikhqbfZm^er _hnk mbf^l ab`a^k maZg ma^ @? 40 h_ ]

9WU& -%,& 7T \O\U ]hl^(k^lihgl^ \nko^l _hk Zfbghia^greZfb]bg^l Z`Zbglm fZmnk^ Z]nem ?# S[XOY bg fb\^

?hl^(k^lihgl^ \nko^l lahp ma^ Zkbmaf^mb\ f^Zg oZen^l Zg] lmZg]Zk] ^kkhkl h_ ma^ f^Zg _hk ]

7T \O\U KLLOIGI_ UL I_IRUUIZGJKVYOVKVZOJKY GMGOTYZ SGZ[XK GJ[RZ YZGMKY UL ?# S[XOY Oak^^ hkZe' bgmkZi^kbmhg^Ze hk ln[\nmZg^hnl ]hl^l h_ ^bma^k ^fh]^ilb]^ hk KA,+--< hg ]Zrl /1(/3 V#O#! k^lnem^] bg ]hl^(]^i^g]^gm k^]n\mbhgl h_ ma^ ?# S[XOY [nk]^g) OZ[) 0( - lnffZkbl^l

@? 0+ Zg] @? 40 oZen^l Zl p^ee Zl \hfiZkblhgl [^mp^^g ma^f [r Z]fbgblmkZmbhg khnm^) =r \hfiZkbg` ma^ mak^^ khnm^l h_ Z]fbgblmkZmbhg' hkZe mk^Zmf^gml ]bfbgbla^] ma^ phkf [nk]^g Zm lb`gb_b\Zgmer ehp^k ]hl^l maZg bgmkZi^kbmhg^Ze hk ln[\nmZg^hnl Z]fbgblmkZmbhgl

#Ab`) 0( 0<' =' > Zg] OZ[) 0( -$) Ahk ^fh]^ilb]^' ma^ @? 0+ oZen^l _hk bgmkZi^kbmhg^Ze Zg] ln[\nmZg^hnl mk^Zmf^gml p^k^ ZiikhqbfZm^er mph_he] Zg] _bo^_he] ab`a^k maZg _hk hkZe mk^Zmf^gm #OZ[) 0( -$) Oa^ ]b__^k^g\^l _hk KA,+--< p^k^ ^o^g fhk^ ikhghng\^]) Oa^ @? 0+ oZen^l _hk bgmkZi^kbmhg^Ze Zg] ln[\nmZg^hnl mk^Zmf^gml p^k^ ZiikhqbfZm^er m^g Zg] /.(mbf^l ab`a^k bg \hfiZkblhg mh ma^ @? 0+ oZen^l _hk ma^ hkZe mk^Zmf^gml)

=r \hfiZkbg` ma^ @? 0+ oZen^l h_ ma^ mph \r\ehh\mZ]^ilbi^imb]^l' ma^ k^lneml p^k^ o^kr

]bo^kl^ ]^i^g]bg` hg ma^ k^li^\mbo^ khnm^ h_ Z]fbgblmkZmbhg) Chp^o^k' ma^ \Ze\neZm^] @? 0+ oZen^ _hk KA,+--< Z_m^k mak^^ bgmkZi^kbmhg^Ze ]hl^l pZl ZiikhqbfZm^er gbg^ mbf^l ab`a^k maZg ma^ @? 0+ oZen^ h_ ^fh]^ilb]^) < \hfiZkblhg h_ ma^ mph ]kn`l Z_m^k mak^^ ln[\nmZg^hnl ]hl^l k^lnem^] bg Zg ZiikhqbfZm^er ,0(_he] ab`a^k @? 0+ oZen^ _hk KA,+--<) Nnkikblbg`er' ma^ @? 0+ oZen^ h_ ^fh]^ilb]^ nlbg` mak^^ hkZe Z]fbgblmkZmbhgl pZl hger mph_he] ehp^k maZg maZm h_ KA,+--<) Nbg\^ ma^ \hlml h_ KA,+--< Zk^ fn\a ehp^k maZg mahl^ h_ ^fh]^ilb]^ Zg] ma^ ]b__^k^g\^ [^mp^^g [hma ]kn`l pZl hger lfZee _hk hkZe Z]fbgblmkZmbhg' Z lbg`e^ hkZe ]hl^ Z`Zbglm fZmnk^ Z]nem lmZ`^l h_ ?# S[XOY pZl hger ^oZenZm^] _hk KA,+--<) < lbg`e^ hkZe Z]fbgblmkZmbhg h_ KA,+--< hg ]Zr /3 V#O# Zelh k^lnem^] bg ]hl^(]^i^g]^gm k^]n\mbhg h_ ma^ pabiphkf [nk]^g) < ]hl^(k^lihgl^ \nko^ pZl \Ze\neZm^] #Ab`) 0( 0<$ Zg] - @? 0+ Zg] @? 40 oZen^l pbma 40 >D Zl p^ee Zl = oZen^l Zk^ ik^l^gm^] bg OZ[) 0( -) Oa^ @? 0+ oZen^ _hk KA,+--< nlbg` Z lbg`e^ hkZe ]hl^ pZl ZiikhqbfZm^er .1(_he] ab`a^k bg \hfiZkblhg mh ma^ mak^^ hkZe Z]fbgblmkZmbhgl)

GOP& -%*& >hfiZkblhg h_ ma^ OT \O\U ^__b\Z\b^l h_ fhghma^kZib^l Z`Zbglm fZmnk^ Z]neml ?# S[XOY bg fb\^ =DF<=GIA<= 9E< 74&%''0 9?9AEIJ G9J=EJ !($"#*($) %*($) AE>=;JAFEI AE DA;=$

2 3 & +?B6 )4;8<" ,+ '$ D8A7 ('% *. P C2:B5 ,+ (' D8A7 ('% *. P C2:B5 R 8< ;6#96! 8< ;6#96! 4)/+ (! FH9C &*$& .$.#''$.! / %$%%%& LI$ ( ! JHA:=E@845 (! FH9C '$, &$.#($.! %$%%%. LI$ ( ! 74&%''0 FH9C! ')$* -$,#+-$-! %$(+-) LI$ ( ! 74&%''0 FH9C! %$-(+- (! A$G$ +$& )$-#,$,! / %$%%%& LI$ ( ! 74&%''0 A$G$! )%$% &-$.#-)$*! / %$%%%& LI$ ( ! 74&%''0 A$G$! %$.',) (! I$;$ &*$' &($%#&,$,! / %$%%%& LI$ ( ! 74&%''0 I$;$! )%$, ')$*#+,$)! / %$%%%& LI$ ( ! 74&%''0 I$;$! %$-)-& 0-%$&&) (! FH9C *$' )$%#+$-! %$%%%. LI$ ( ! =DF<=GIA<= FH9C! (+$* &)$.#-.$-! %$(+-) LI$ ( ! =DF<=GIA<= FH9C! %$-+-& (! A$G$ **$, ))$)#,%$%! / %$%%%& LI$ ( ! =DF<=GIA<= A$G$! '%-$* ..$'#)(-$'! / %$%%%& LI$ ( ! =DF<=GIA<= A$G$! %$-+*, (! I$;$ ''*$, &-%$'#'-'$+! / %$%%%& LI$ ( ! =DF<=GIA<= I$;$! *&*$% '*)$-#&%)&! / %$%%%& LI$ ( ! =DF<=GIA<= I$;$! %$,)(' &! FH9C &-+$+ &&&$%#(&($*! / %$%%%& LI$ ( ! 74&%''0 FH9C! +-+$, &+-$*#',.-! / %$%%%& LI$ ( ! 74&%''0 FH9C! %$+%-+ ' 7H=I=EJ=< 9H= J@= 32 *% 9E< 32 .* L9CK=I MAJ@ .*% ;FE>A<=E;= AEJ=HL9CI 15! 9E< ;F=>>A;A=EJI F> <=J=HDAE9JAFE ! 9I M=CC 9I P L9CK=I" >FH 9 : <=J=HDAE9JAFE F> IA?EA>A;9EJ >=H=E;=I$ 8A?EA>A;9EJ >=H=E;= AE 32 *% JF A;9EJ >=H=E;= AE 32 .* JF

9WU& -%-& 7T \O\U ]hl^(k^lihgl^ \nko^l h_ ^fh]^ilb]^ Zg] KA,+--< Z`Zbglm fZmnk^ Z]neml h_ ?# S[XOY

?hl^(k^lihgl^ \nko^l lahp ma^ Zkbmaf^mb\ f^Zg oZen^l pbma N@H pbma Z `khni lbs^ h_ _bo^ ZgbfZel i^k ]kn` Zg] ]hl^) @__b\Z\r pZl \Ze\neZm^] Zl k^eZmbo^ gnf[^k h_ k^\ho^k^] phkfl \hfiZk^] mh ma^ gh(]kn` \hgmkhe bg i^k\^gmZ`^) ?hlZ`^l p^k^ eh` ,+ mkZgl_hkf^] Zg] eh`blmb\ k^`k^llbhgl p^k^ \Ze\neZm^] pbma mhi oZen^l \hglmkZbg^] [^mp^^g + Zg] ,++ ) OkbZg`e^l bg]b\Zm^ Z lbg`e^ ]hl^ h_ KA,+--< #eb`am [en^$' \bk\e^l mak^^ ]hl^l h_ KA,+--< #]Zkd [en^$ Zg] ljnZk^l mak^^ ]hl^l h_ ^fh]^ilb]^ #k^]$ Z_m^k <$ hkZe' =$ bgmkZi^kbmhg^Ze Zg] >$ ln[\nmZg^hnl Z]fbgblmkZmbhg) @__b\Z\b^l p^k^ l^m mh s^kh b_ f^Zg h_ ma^ phkf \hngml pZl ab`a^k maZg ma^ f^Zg h_ ma^ \hkk^lihg]bg` \hgmkhe `khni) Ankma^kfhk^' ma^ \hkk^lihg]bg` N@H oZen^l h_ ma^ Z__^\m^] `khnil lmZkm _khf s^kh) Oa^ gh(]kn` \hgmkhel p^k^ l^m mh ,+ (/ f`*d` mh Zeehp eh` ,+ mkZgl_hkfZmbhg h_ ]hlZ`^l)

,1- 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

7T \O\U KLLOIGI_ UL <4&%''/ GMGOTYZ JK\KRUVSKTZGR YZGMKY UL ?# S[XOY =hma lbg`e^ Zg] fnembie^ KA,+--< ]hl^l hg ]Zr -3 Zg] ]Zrl -1(-3 k^lnem^] bg ]hl^( ]^i^g]^gm k^]n\mbhgl bg ma^ gnf[^k h_ k^\ho^k^] phkfl #Ab`) 0( 1<' = Zg] Nniie^f^gmZkr OZ[) 0( 0$) Rabe^ Z lbg`e^ Z]fbgblmkZmbhg h_ ,+ f`*d` ]b] ghm k^lnem bg Zgr ZiiZk^gm ^__^\ml' ,++ f`*d` hk ab`a^k ]hlZ`^l Zek^Z]r ^ebfbgZm^] ma^ phkf [nk]^g \hfie^m^er) Oak^^ hkZe ]hl^l h_ KA,+--< Z`Zbglm ]^o^ehif^gmZe lmZ`^l hg ]Zrl -1(-3 Zelh k^lnem^] bg g^Zker \hfie^m^ hk \hfie^m^ \nk^ kZm^l lmZkmbg` _khf ,+ f`*d`) Oa^k^_hk^' Zg ZiikhqbfZm^er ,+(_he] ehp^k ]hlZ`^ h_ KA,+--< pZl ln__b\b^gm mh \nk^ ma^ bg_^\mbhg pbma _nkma^k ]^o^ehi^] eZkoZe lmZ`^l Zg] bffZmnk^ Z]nem phkfl pbma mak^^ ]hl^l bg \hfiZkblhg mh Z lbg`e^ ]hl^) Oa^ ^__b\Z\r h_ lbg`e^ Zg] fnembie^ KA,+--< ]hl^l hg ]Zr ,/ Zg] ]Zrl ,-(,/ k^li^\mbo^er' mZk`^mbg` ma^ ablmhmkhib\ G-' Zelh k^lnem^] bg ]hl^(]^i^g]^gm lb`gb_b\Zgm k^]n\mbhgl h_ ma^ phkf [nk]^g #Ab`) 0( 1>' ? Zg] Nniie^f^gmZkr OZ[) 0( 0$) Dg iZkmb\neZk' mak^^ ]hlZ`^l h_ ,++ f`*d` KA,+--< hk Z lbg`e^ Z]fbgblmkZmbhg h_ -0+ f`*d` KA,+--< p^k^ k^jnbk^] _hk \hfie^m^ ^ebfbgZmbhg h_ pabiphkfl) Dg \hgmkZlm mh ma^ ^__b\Z\r Z`Zbglm G-' ma^ ^__^\ml h_ KA,+--< Z`Zbglm G, p^k^ ghm ln__b\b^gm bg ma^ lbg`e^ ]hl^ k^`bf^g) Rabe^ mak^^ ]hl^l h_ ,++ f`*d` KA,+--< hg ]Zrl ,(. V#O) p^k^ ln__b\b^gm mh \hfie^m^er \nk^ ma^ fb\^' Z lbg`e^ ]hl^ hg ]Zr . V#O)' nlbg` ^o^g 0++ f`*d`' pZl ghm Z[e^ mh lb`gb_b\Zgmer k^]n\^ phkf [nk]^gl #Ab`) 0( 1@' A Zg] Nniie^f^gmZkr OZ[) 0( 0$)

,1. 1NGVZKX *

9WU& -%.& 7T \O\U ^__b\Z\r h_ KA,+--< Z`Zbglm eZkoZe Zg] bffZmnk^ lmZ`^l h_ ?# S[XOY bg fb\^

=hq iehml lahp ma^ f^]bZg gnf[^kl Zg] jnZkmbe^l h_ k^\ho^k^] Z]nem ?# S[XOY Z_m^k mk^Zmf^gm Z`Zbglm G.' G/ Zg] bffZmnk^ Z]neml #<' =$' ablmhmkhib\ G- #>' ?$ Zg] ablmhmkhib\ G, #@' A$ nlbg` [hma' lbg`e^ #<' >' @$ Zg] mkbie^ #=' ?' A$ ]hl^ k^`bf^gl pbma pbld^kl k^ik^l^gmbg` fbgbfZe Zg] fZqbfZe oZen^l) Bkhni lbs^l p^k^ 0 fb\^ i^k ]kn` Zg] ]hl^) & Zkbmaf^mb\ f^Zg6 % <7+)+, ol) \hgmkhe6 %% <7+)++, ol) \hgmkhe)

,1/ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

-&. 7WaQcaaW]\

Oa^ fZchkbmr h_ anfZg `Zlmkhbgm^lmbgZe g^fZmh]^ bg_^\mbhgl Zk^ \Znl^] [r /# R[SHXOIUOJKY ' /# J[UJKTGRK' :# GSKXOIGT[Y! ># YZKXIUXGROY Zg] ?# ZXOINO[XG V3W) Ra^k^Zl ZoZbeZ[e^ ]kn`l Zk^ nlnZeer ab`aer ^__^\mbo^ Z`Zbglm /# R[SHXOIUOJKY bg Z lbg`e^ ]hl^ k^`bf^g ' Zm e^Zlm fnembie^ ]hlZ`^l h_ mahl^ ]kn`l Zk^ k^jnbk^] mh \nk^ ahhdphkf' mak^Z]phkf Zg] iZkmb\neZker pabiphkf bg_^\mbhgl V4'.4W) Dg Z]]bmbhg mh ma^ ^ghkfhnl bfiZ\m hg anfZg f^]b\bg^' ma^ `^gnl ?XOIN[XOY! ebd^ ?# Y[OY! bl Zelh \hglb]^k^] mh [^ Z ]hl^(ebfbmbg` g^fZmh]^ _hk fhlm \nkk^gm Zgma^efbgmb\l bg Z oZkb^mr h_ ahlml h_ o^m^kbgZkr bfihkmZg\^ V,.W) Chp^o^k' mk^Zmf^gm himbhgl Zk^ h_m^g ebfbm^]) Ahk ^qZfie^' Z eZk`^ gnf[^k h_ ]kn`l #]b^mare\Zk[ZfZsbg^' bo^kf^\mbg' ibi^kZsbg^' irkZgm^e$ k^`blm^k^] mh mk^Zm g^fZmh]^ bg_^\mbhgl bg ]h`l Zk^ eZ\dbg` ln__b\b^gm ^__b\Z\r Z`Zbglm ?# \[RVOY V,-W)

,10 1NGVZKX *

Dg hk]^k mh ^oZenZm^ ma^ ^__^\ml h_ ]kn`l Z`Zbglm ma^ ablmhmkhib\ lmZ`^l h_ ?# S[XOY ' Z ]^mZbe^] dghpe^]`^ h_ ma^ mbf^ \hnkl^ h_ ]^o^ehif^gm pbmabg ma^ ahlm bl k^jnbk^]) Nbg\^ ]ZmZ bg ma^ ebm^kZmnk^ Zk^ h_m^g jnbm^ he] Zg] ]b__^k bg fZgr h[l^koZmbhgl' ^li^\bZeer k^`Zk]bg` ma^ gnf[^k Zg] ma^ mbf^ \hnkl^ h_ fhneml #_hk k^ob^p l^^ V,0W$' ma^ blheZm^ nl^] bg ma^ ik^l^gm lmn]r pZl ln[c^\m^] mh Zg bg(]^ima iZkZlbmheh`b\Ze ZgZerlbl) Ankma^kfhk^' ma^ \hnkl^ h_ bg_^\mbhg lmkhg`er ]^i^g]l hg ma^ k^li^\mbo^ fhnl^ lmkZbg V,2W Zg] ?# S[XOY blheZm^ V,3W' fZdbg` Z ]^mZbe^] \aZkZ\m^kblZmbhg ^o^g fhk^ \kn\bZe) Oa^ iZkZlbmheh`b\Ze ]ZmZ h[mZbg^] a^k^ p^k^ bg Z`k^^f^gm pbma _bg]bg`l h_ KZg^lZk Zg] >khee V,1W) Oa^r k^ihkm^]' maZm hg ]Zr -+ V#O#! Zee eZkoZ^ p^k^ _hng] ^f[^]]^] bg ma^ lnk_Z\^ ^ibma^ebnf pbma ma^bk ihlm^kbhk ^g]l ^qmkn]bg` bgmh ma^ enf^g h_ ma^ `nm) Dg ma^ ik^l^gm lmn]r' mabl h[l^koZmbhg pZl fZ]^ _khf ]Zr -, hgpZk]l) Dg \hgmkZlm mh KZg^lZk Zg] >khee' p^ lmbee _hng] Z lfZee [nm lb`gb_b\Zgm gnf[^k h_ ablmhmkhib\ lmZ`^l ngmbe ]Zr -4 V#O# Chp^o^k' ma^ i^kbh] bg pab\a ablmhmkhib\ lmZ`^l p^k^ ^q\enlbo^er ik^l^gm pZl Zefhlm ma^ lZf^) Dgm^k^lmbg`er' h[l^koZmbhgl [r Kbd^ V.2W p^k^ Zelh bg ebg^ pbma ]ZmZ lahpg a^k^) Oa^r aZo^ lahpg' maZm ma^ _^fZe^*fZe^ kZmbh lm^Z]ber ]^o^ehil mhpZk]l fhk^ fZe^ phkfl Zg] maZm fZe^ ?# S[XOY lnkobo^ ehg`^k maZg _^fZe^l' pab\a bl bg fZkd^] \hgmkZlm mh hma^k iZkZlbmb\ g^fZmh]^ li^\b^l' pa^k^ _^fZe^l lnkobo^ ehg`^k maZg fZe^l V.2W) Dg ma^ ik^l^gm lmn]r' gh OT \O\U ^__b\Z\r h_ ma^ Zfbghia^greZfb]bg^ Zfb]Zgm^e pZl _hng] Z`Zbglm iZm^gm ?# S[XOY bg_^\mbhgl bg fb\^) Oak^^ hkZe ]hl^l h_ 0++ f`*d` Zfb]Zgm^e ]b] ghm k^]n\^ ma^ phkf [nk]^g bg \hfiZkblhg mh ma^ gh(]kn` \hgmkhe) Oa^ ^__b\Z\r h_ Zfb]Zgm^e Z`Zbglm ?# S[XOY pZl bgo^lmb`Zm^] ik^obhnler Zg] pZl Zelh _hng] mh [^ hger fh]^kZm^ V-/W) Oa^k^_hk^' Zfb]Zgm^e pZl ghm _nkma^k ^oZenZm^] bg ma^ ik^l^gm^] lmn]r) Dg \hgmkZlm' mak^^

\hgl^\nmbo^ hkZe ]hl^l pbma ^bma^k mkb[^g]bfb]bg^ hk ]hfie^m^ ^ebfbgZmbhg h_ ma^ phkf [nk]^g pZl Z\ab^o^] [r mak^^ hkZe ]hl^l nlbg` ^bma^k -0 f`*d` mkb[^g]bfb]bg^ hk ,++ f`*d` ]k^fhiahk @G*]^bhgbl^] pZm^k$ Zk^ ma^ fhlm ebd^er ^qieZgZmbhg _hk ma^ h[l^ko^] ia^ghf^ghg) Oa^ eZk`^k mkb[^g]bfb]bg^ fhe^\ne^

,11 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

\Zg [^ lnli^\m^] mh ]b__nl^ fhk^ lehper bgmh ma^ Zjn^hnl ^gobkhgf^gm) Dm \Zg [^ Zllnf^] maZm k^e^Zl^ h_ ]kn`l _khf ma^ ]bli^klbhg h\\nkl fhk^ kZib]er bg ma^ ]b`^lmbo^ mkZ\d ng]^k f^\aZgb\Ze fbqbg` bg ma^ ik^l^g\^ h_ [be^ lZeml maZg bg ma^ i^kbmhg^nf Zg] maZm iZllbo^ ]b__nlbhg bl h_ fbghk bfihkmZg\^ bg ma^ `nm) Oa^ Z[l^g\^ h_ ^__b\Z\r h_ mkb[^g]bfb]bg^ Zg] ]# XGZZO Zg] :# HXGYOROKTYOY bg kZml' /# IGTOT[S bg ]h`l' \rZmahlmhf^l bg ahkl^l' ?# IUR[HXOLUXSOY Zg] 6# IUTZUXZ[Y bg la^^i Zg] 2# \O\OVGX[Y bg \Zmme^ nlbg` _Zbker ehp ]hlZ`^l h_ ,(,+ f`*d` KA,+--< p^k^ k^ihkm^] V/4W) Oa^k^ p^k^ Zelh ]b__^k^g\^l bg ^__b\Z\r \hfiZkbg` ^fh]^ilb]^ Zg] KA,+--< bg ma^ ik^l^gm lmn]r' [nm ma^ fZ`gbmn]^ h_ ma^l^ ]b__^k^g\^l pZl ]^i^g]^gm hg ma^ khnm^ h_ Z]fbgblmkZmbhg)

Chp^o^k' ^fh]^ilb]^ ZepZrl i^k_hkf^] lb`gb_b\Zgmer [^mm^k maZg KA,+--< nlbg` ma^ @? 0+ oZen^ Zl \kbm^kbhg) Oa^ ]b__^k^g\^ [^mp^^g [hma ]kn`l pZl iZkmb\neZker lfZee _hk ma^ hkZe Z]fbgblmkZmbhg' pab\a Zelh i^k_hkf^] [^mm^k maZg ma^ bgmkZi^kbmhg^Ze Zg] ma^ ln[\nmZg^hnl khnm^) Oa^ @? 0+ Zg] @? 40 oZen^l _hk KA,+--< p^k^ hger ,)4 Zg] ,)0 _he] ab`a^k maZg mahl^ _hk ^fh]^ilb]^' k^li^\mbo^er) Ahk bml lnbmZ[bebmr bg fZll(]kn`(mk^Zmf^gm ikh`kZfl' ]kn`l g^^] Z ab`a lZ_^mr Zg] ikh]n\mbhg \hlml lahne] [^ Zl ehp Zl ihllb[e^) ?n^ mh ma^ _Z\m maZm ma^ \eZll h_ Zfbghia^greZfb]bg^l bl

,12 1NGVZKX * lmbee \hglb]^k^] mh [^ ihm^gmbZeer aZsZk]hnl V0+W Zg] KA,+--< ]h^l aZo^ fn\a \a^Zi^k ikh]n\mbhg \hlml maZg ^fh]^ilb]^ #]n^ mh hfbllbhg h_ lrgma^mb\ ]^kboZmblZmbhg$ V/2W' lbg`e^ ]hl^ ^qi^kbf^gml Zg] mk^Zmf^gml mZk`^mbg` ]^o^ehif^gmZe lmZ`^l p^k^ hger i^k_hkf^] pbma KA,+--<) Dg Z]]bmbhg' gh ]ZmZ k^`Zk]bg` ma^ ^__^\ml h_ KA,+--< hg Zgr lmZ`^l h_ ?XOIN[XOY lii) aZo^ [^^g in[ebla^] ik^obhnler) Oh ^qZfbg^ pa^ma^k KA,+--< aZl ma^ ihm^gmbZe mh k^ieZ\^ ma^ fhk^ ^qi^glbo^ ^fh]^ilb]^ bg ma^kZir h_ ?XOIN[XOY lii)' bm bl bfihkmZgm mh ]^m^kfbg^ ma^ lnbmZ[bebmr h_ KA,+--< Zl Z [khZ](li^\mknf Zgma^efbgmb\) k^fhiahk @G*pZm^k ]bli^klbhg

,13 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY p^k^ k^jnbk^] mh Z\ab^o^ Z \hfie^m^ ^ebfbgZmbhg h_ iZm^gm ?# S[XOY bg_^\mbhgl bg ma^ ik^l^gm lmn]r) Oa^ fhk^ maZg ,+(_he] bg\k^Zl^ bg ^__b\Z\r [^mp^^g mak^^ ]hl^l nlbg` >k^fhiahk*pZm^k Zg] Z lbg`e^ ]hl^ nlbg` ma^ himbfbl^] Kkh_^g]^k Ä _hkfneZmbhg ^fiaZlbl^l maZm ^o^kr ]kn` _hkfneZmbhg aZl mh [^ himbfbl^] _hk ^Z\a ]kn` Zg] ahlm li^\b^l Zg] maZm ]kZfZmb\ ]^\k^Zl^l bg k^jnbk^] ]kn` ]hlZ`^l Zk^ ihllb[e^ pa^g nlbg` Zg himbfbl^] _hkfneZmbhg) Dg Z]]bmbhg' himbfbsZmbhg h_ _hkfneZmbhgl Zelh ]^\k^Zl^l ma^ kbld h_ bgmhqb\Zmbhgl Zg] ma^ \hlml h_ mk^Zmf^gm' bg iZkmb\neZk' b_ ]kn`l \Zg [^ mZk`^m^] li^\b_b\Zeer mhpZk]l ma^ eh\Zmbhg h_ ma^ iZkZlbm^' K#M#! ma^ `nm' Zohb]bg` ab`a ]kn` \hg\^gmkZmbhgl bg mblln^l' K#M#! ma^ [kZbg' pab\a fZr [^ bfihkmZgm _hk lb]^ ^__^\ml) Dg \hg\enlbhg' OT \O\U mk^Zmf^gml pbma k^eZmbo^er ab`a ]hl^l h_ KA,+--< k^lnem^] bg \hfie^m^ ^ebfbgZmbhg h_ ?# S[XOY ' bg\en]bg` fZmnk^ Z]nem Zg] bffZmnk^ Z]nem phkfl Zl p^ee Zl ablmhmkhib\ Zg] _nkma^k ]^o^ehi^] eZkoZe lmZ`^l bg Z lbg`e^(]hl^ k^`bf^g) Nbg\^ hger ghg( himbfbl^] _hkfneZmbhgl p^k^ ^oZenZm^] bg mabl lmn]r' \hglb]^kZ[er ehp^k ]hlZ`^l fb`am [^ Z\ab^oZ[e^' nlbg` _hkfneZmbhgl himbfbl^] _hk iZkmb\neZk ahlm li^\b^l) ?^libm^ ma^ _Z\m maZm ]^mZbe^] lZ_^mr Zg] iaZkfZ\hdbg^mb\ lmn]b^l Zk^ lmbee \hfie^m^er fbllbg` _hk anfZgl' ]blmbg\m ^__^\ml h_ KA,+--< Z`Zbglm ma^ nlnZeer ]hl^(ebfbmbg` `^gnl ?XOIN[XOY bg ma^ fhnl^ fh]^e ln``^lm maZm \r\ehh\mZ]^ilbi^imb]^l Zk^ nl^_ne \Zg]b]Zm^l _hk ]^o^ehif^gm Zl Z`^gml Z`Zbglm anfZg NOCl Zg] g^fZmh]^ bg_^\mbhgl h_ ebo^lmh\d ZgbfZel)

,14 1NGVZKX *

-&/ ESTS`S\QSa

,) Zkmar EN' =Zltx^s HB' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 ma^ ikh[e^f h_ a^efbgmabZl^l) KGhN I^`e Okhi ?bl 1' ^,03-) .) Fghii N' Nm^bgfZgg K' F^bl^k E' Pmsbg`^k E' -+,-' I^fZmh]^ bg_^\mbhgl5 lhbe( mkZglfbmm^] a^efbgmal Zg] mkb\abg^eeZ) Dg_^\m ?bl >ebg Ihkma Q' >hhi^k @N' -+++' Oa^ in[eb\ a^Zema lb`gb_b\Zg\^ h_ ?XOIN[XOY ZXOINO[XG ) KZkZlbmheh`r ,-,' 2.(40) 2) Rhke] C^Zema Jk`ZgbsZmbhg' -+,,' RCJ fh]^e eblm h_ ^ll^gmbZe f^]b\bg^l5 ,2ma eblm' HZk\a -+,,) B^g^oZ5 Rhke] C^Zema Jk`ZgbsZmbhg) 3) =^mahgr E' =khhd^k N' Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 15 ^,0/4) ,+) F^bl^k E' Pmsbg`^k E' -+,+' Oa^ ]kn`l p^ aZo^ Zg] ma^ ]kn`l p^ g^^] Z`Zbglm fZchk a^efbgma bg_^\mbhgl) <]o KZkZlbmhe 2.' ,42(-.+) ,,) ?bZpZkZ <' ?kZd^ GE' Nnlpbeeh MM' FbaZkZ E' =ng]r ?<' N\hmm H@' CZei^ggr >' NmhmaZk] EM' Kkb\aZk] MF' -++4' <=D Kn[eblabg`'RZeebg`_hk])

,2+ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

,/) F^^ebg` E@' ,41,' @qi^kbf^gmZe mkb\ankbZlbl) DD) ' -+++' I^fZmh]^ iZkZlbm^l h_ o^km^[kZm^l5 ma^bk ]^o^ehif^gm Zg] mkZglfbllbhg) ><=D Kn[eblabg` RZeebg`_hk]) ,1) KZg^lZk ON' >khee I<' ,43+' Oa^ eh\Zmbhg h_ iZkZlbm^l pbmabg ma^bk ahlml5 lbm^ l^e^\mbhg [r ?XOIN[XOY S[XOY bg ma^ eZ[hkZmhkr fhnl^) Dgm E KZkZlbmhe ,+' -1,(-2.) ,2) RZd^ebg ?' ,412' <\jnbk^] bffngbmr mh ?XOIN[XOY S[XOY bg ma^ Ze[bgh eZ[hkZmhkr fhnl^) KZkZlbmheh`r 02' 0,0(0-/) ,3) Ehaglmhg >@' =kZ]e^r E@' =^agd^ EH' HZmma^pl FM' @el^ FE' -++0' DlheZm^l h_ ?XOIN[XOY S[XOY ^eb\bm ]b__^k^gm Z]Zimbo^ bffng^ k^lihgl^l bg ma^bk fnkbg^ ahlm) KZkZlbm^ Dffnghe -2' 14(23) ,4) Fk{\d^g E' CZk]^k <' E^l\ad^ K' Che]^g(?r^ G' J">hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' abg^l^ Zgma^efbgmab\ ]kn` mkb[^g]bfb]bg^ bg \ebgb\Ze mkbZel Zg] eZ[hkZmhkr bgo^lmb`Zmbhgl) <\mZ Okhi ,-1' ,,0(,-1) -,) N\abff^e <' aZke^l N' >knma^kl G' Fhd ?E' FkZ^f^k A' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ Z]nem ?XOIN[XOY \[RVOY bg_^\mbhgl bg ]h`l) KZkZlbmhe M^l ,+0' ,2(--) --) H^aeahkg C' N\afZae B' Ak^l^ H' H^obll^g D' CZk]^k <' Fkb^`^k FE' -++0' @__^\ml h_ Z \hf[bgZmbhgl h_ ^fh]^ilb]^ Zg] ikZsbjnZgm^e hg iZkZlbm^l h_ k^imbe^l Zg] kh]^gml) KZkZlbmhe M^l 42' 10(14) -.) N\afZae B' H^aeahkg C' CZk]^k <' Febfi^e N' Fkb^`^k FE' -++2' @__b\Z\r h_ \hf[bgZmbhg h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e Z`Zbglm eZkoZe Zg] Z]nem lmZ`^l h_ g^fZmh]^l # ?XOIN[XOY S[XOY! /TMOUYZXUTM_R[Y IGTZUTKTYOY $ bg kh]^gml) KZkZlbmhe M^l ,+,' 22(3/) -/) Rheep^[^k C' Ib^f^kl @' Aen\d^ R'

,2, 1NGVZKX *

-0) Nm^bgfZgg K' Uahn SI' ?n UR' EbZg` ET' SbZh NC' Rn US' Uahn C' Pmsbg`^k E' -++3' Okb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ _hk mk^Zmbg` lhbe(mkZglfbmm^] a^efbgmal' >ZXUTM_RUOJKY YZKXIUXGROY Zg] ?GKTOG lii)5 hi^g(eZ[^e kZg]hfbs^] mkbZe) KGhN I^`e Okhi ?bl -' ^.--) -1) SbZh NC' Cnb(Hbg` R' OZgg^k H' Pmsbg`^k E' >ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) -2) SbZh NC' Rn US' UaZg` EC' RZg` NL' RZg` NC' Lbn ?>' RZg` >' -++2' >ebgb\Ze h[l^koZmbhg hg 344 \abe]k^g bg_^\m^] pbma bgm^lmbgZe g^fZmh]^l Zg] mk^Zm^] pbma mkb[^g]bfb]bg^ ^gm^kb\ \hZm^] mZ[e^ml) >abg E KZkZlbm ?bl -0' .2-(.20) -3) Cn T' SbZh NC' ' Fkn`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fkn\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+) .,) Bn^lm H' =nee F' RZed^k ME' hgghk Q' CZk]^k <' Che]^g(?r^ G' Chii^k I<' -++2' Oa^ \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e' NGJ(,' bl k^jnbk^] _hk ma^ Z\mbhg h_ ma^ gho^e \r\eh(h\mZ]^ilbi^imb]^ Zgma^efbgmb\' ^fh]^ilb]^' bg 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' ,022(,033) .-) NZ^`^k =' N\afbmm(Rk^]^ CK' ?^agaZk]m H' =^gm^g RK' Fkn\d^g E' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' Rb^`Zg] C' Rng]^keb\a A' -++,' GZmkhiabebg(ebd^ k^\^imhk _khf ma^ iZkZlbmb\ g^fZmh]^ 6GKSUTIN[Y IUTZUXZ[Y Zl mZk`^m _hk ma^ Zgma^efbgmb\ ]^ilbi^imb]^ KA,+--<) Aa^g R' O^kZ]Z H' >a^g` EO' ,441' >aZkZ\m^kbsZmbhg h_ ln[mri^l h_ `ZffZ( Zfbgh[nmrkb\ Z\b] k^\^imhkl bg Zg /YIGXOY fnl\e^ ik^iZkZmbhg [r [bg]bg` ZllZr Zg] [bg]bg` h_ KA,+--<' Z g^p Zgma^efbgmb\' hg ma^ k^\^imhkl) KZkZlbmhe M^l 3-' 42(,+,)

,2- 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

./) Hbeml\a NH' Fkn\d^g E' ?^f^e^k E' EZgll^g DE' Fkn`^k I' CZk]^k <' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' ?^\k^Zl^] ^fh]^ilb]^ l^glbmbobmr bg ng\(/4 `ZffZ( Zfbgh[nmrkb\ Z\b] #B<=<$(k^\^imhk(]^_b\b^gm 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe /-' 21,(22+) .0) Nmhee IM' ,4-.' Dgo^lmb`Zmbhgl hg ma^ \hgmkhe h_ ahhdphkf ]bl^Zl^) SQ) Zg E Uhhe 12' -./+(-./.) .2) Kbd^ @C' ,414' @`` hnminm h_ ?XOIN[XOY S[XOY #N\akZgd' ,233$) E KZkZlbmhe 00' ,+/1( ,+/4) .3) Hhmneldr C' >akblmhihnehl <' -++/' Abmmbg` fh]^el mh [bheh`b\Ze ]ZmZ nlbg` ebg^Zk Zg] ghgebg^Zk k^`k^llbhg5 Z ikZ\mb\Ze `nb]^ mh \nko^ _bmmbg`) Jq_hk] Pgbo^klbmr Kk^ll' I^p Thkd) .4) NninmmZfhg`dhe T' Kk^fZlZmabZg I' =anfbfnZg` F' RZrpZ ?' Ibe`Zgnphg` N' FZkniahg` @' C' Hb\aZ^e =A' CZbg^l CR' N^pZk] MG' ,44,' ' Ib\aheZl ?M' >hq BB' >hg]^k B<' -+,,' @__b\Z\r h_ Z \hf[bg^] hkZe _hkfneZmbhg h_ ]^kjnZgm^e(Z[Zf^\mbg Z`Zbglm ma^ Z]nem Zg] eZkoZe lmZ`^l h_ g^fZmh]^l bg la^^i' bg\en]bg` Zgma^efbgmb\(k^lblmZgm lmkZbgl) Q^m KZkZlbmhe ,3,' ,3+(,4.) /.) Nnma^keZg] D' N\hmm D' -+,+' BZlmkhbgm^lmbgZe g^fZmh]^l h_ la^^i Zg] \Zmme^ ( [bheh`r Zg] \hgmkhe) =eZ\dp^ee Kn[eblabg`' Jq_hk]) //) Rn US' AZg` TT' Gbn TN' -++1' @__^\m h_ Z gho^e ]kn` Ö ^gm^kb\ \hZm^] mkb[^g]bfb]bg^ bg ma^ mk^Zmf^gm h_ bgm^lmbgZe g^fZmh]^ bg_^\mbhgl) Uahg``nh Eb Na^g` >ahg` Sn^ Tn Eb Na^g` >ahg` =bg` UZ Uab -/' -.Ö-1) /0) TnZg B' Sn E' Ln O' RZg` =' UaZg` M' R^b >' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l ,+' 3.(4+)

,2. 1NGVZKX *

/1) K^mkr B' eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) /3) Iphln P' QZk`Zl H' CZk]^k <' F^bl^k E' -+,,' @__b\Z\r h_ ma^ \r\ehh\mZ]^ilbi^imb]^ KA,+--< Z`Zbglm 6KROMSUYUSUOJKY HGQKXO OT \OZXU Zg] OT \O\U ) KZkZlbmheh`r ,.3' ,,4.(,-+,) /4) ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' N\agb^]^k O' FZe[^ E' H^g\d^ I' -+++' 7T \O\U Z\mbobmb^l h_ ma^ g^p Zgma^efbgmb\ ]^ilbi^imb]^ KA ,+--<) KZkZlbmhe M^l 31' ,4/( ,44) 0+) @i^ >' FZfbgldr M' -+,.' I^p Z]oZg\^f^gm bg Zgma^efbgmb\ ]kn`l bg o^m^kbgZkr f^]b\bg^) Ok^g]l KZkZlbmhe -4' ,-4(,./)

,2/ 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

-&0 Fc^^]`bW\U W\T]`[ObW]\

Fc^^ZS[S\bO`g GOP& -%+& Gh\ZeblZmbhg h_ ?# S[XOY lmZ`^l makhn`ahnm ik^iZm^g\r

OZ[e^ lahpl eh\ZeblZmbhg h_ ?# S[XOY lmZ`^l pbmabg ma^bk fnkbg^ ahlm bg ma^ \hnkl^ h_ ik^iZm^gm i^kbh]) NmZ`^l Zk^ ln[]bob]^] bgmh #b$ ^``l' #bb$ eZkoZ^ _hng] bg ma^ bgm^lmbgZe \hgm^gml #_k^^ eZkoZ^$' #bbb$ eZkoZ^ \hfie^m^er i^g^mkZm^] bgmh ma^ ^ibma^ebnf h_ ]nh]^gnf' \hehg hk \Z^\nf #ablmhmkhib\ eZkoZ^$ Zg] #bo$ eZkoZ^ ^qmkn]bg` ma^bk ihlm^kbhk ^g]l bgmh ma^ enf^g h_ ma^ `nml #^qmkn]bg` eZkoZ^$) <[lhenm^ gnf[^kl h_ lmZ`^ \hngml i^k k^`bhg Zk^ `bo^g _hk ^Z\a fhnl^ bg]bob]nZeer)%' _neer ^f[krhgZm^] ^``l6 %%' ng^f[krhgZm^] ^``l)

,20 1NGVZKX *

Fc^^ZS[S\bO`g GOP& -%,& O^fi^kZmnk^ ]^i^g]^g\r h_ ?# S[XOY eZkoZe ]^o^ehif^gm bg ^``l ! ! 1:>5695:?54 7: %! .2=?7288B >5695:?54 7: %! -@88B 45A58;<54 7: %! ,565:5=2?54 7: %! ,.. &C+ #*C+ $(C+ %(C+ &C+ #*C+ $(C+ %(C+ &C+ #*C+ $(C+ %(C+ &C+ #*C+ $(C+ %(C+

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

! '#.# "&.' )%.' $$. $.# &&. ! "&.) '.$ '#.! )".& (".! !'.) ! "&.' %.# '#.# )$.' '!.$ "(.& ! %.) $.$ )$.! )%.& ('.% !".% " ! '(.) "!.! '#.# "&.' '#.# "&.' ! '(.& "!.$ '".' "'.# '&." "#.( ! ( . " . ' . # . '".' "'.# ! ! %".) $'.! #%.' &$.# ! ! $!." %(.( #%.# &$.' ! ! #%.' &$.# !".% ('.% "& ! %$." $%.( $".) %'.! ! $!.$ %(.& #&.$ &#.& ! #(.) &!.! #%. &%. ! ! !$.# (%.' ! ! !!.( ((." ! ! ! . ) . #$ ! ! ! ! ! ! ! ! ! ! $".! %'.) ! ! $ .) %).! )&.& $.$ ! ##.# &&.' )$.' %.# $! ! ! ! ! ! ! ! ! ! ! ! ! .% ().% %0 ! ! ! ! ! ! ! ! ! $.% )%.% ! %.) )$.!

+-,* +.96 4367 485101/.7132. ?KK5! ?Zrl ihlm inkb_b\Zmbhg

,21 1_IRUUIZGJKVYOVKVZOJKY GTJ TOIUZOTOIY GMGOTYZ ?# S[XOY

Fc^^ZS[S\bO`g GOP& -%-& ?^l\kbimbo^ lmZmblmb\l _hk ^Z\a mk^Zmf^gm `khni #\eZllb_b^] [r bg]bob]nZe ]kn`l' ]hl^ k^`bf^g Zg] khnm^ h_ Z]fbgblmkZmbhg$

4*-,! B8@55 >@1; 4>A5A

+>=B@>; %"$ <7#:7 ("$ <7#:7 %$ <7#:7 &( <7#:7 ($ <7#:7 %$$ <7#:7

-51= #".)' $&.( %&. "#.& !!." ".## /, !#.&& !". # !&.)# !%.)% ).(# #.(# . () % % % % % %

4*-,! B8@55 9=B@1?5@9B>=51; 4>A5A

+>=B@>; ("$ <7#:7 %$ <7#:7 &( <7#:7 ($ <7#:7 %$$ <7#:7

-51= #".)' #&." ).$ #.$ /, !#.&& !$.$% %.)( %.$!

. () % % % % %

+92-/6.252.26/, ;19// 79,4 .7:/:

&76;974 # " 50!30 % " 50!30 #" 50!30 $% 50!30 %" 50!30 #"" 50!30

(/,6 #".)' %)." #%. %.( *' !#.&& "". ). # %.'" ) () % % % % % %

+92-/6.252.26/, ;19// 26;9,8/92;76/,4 .7:/:

&76;974 % " 50!30 #" 50!30 $% 50!30 %" 50!30 #"" 50!30

(/,6 #".)' #&.( "'.& (.( *' !#.&& !$. # &.&" '.(%

) () % % % % %

,22 1NGVZKX *

/,#"$$), A7?55 =?1: 4=@5@

*=

/,#"$$), A7?55 85?8A=<51: 4=@5@

*=

/,#"$$), A7?55 @B23BA1<5=B@ 4=@5@

*=

/,#"$$), =<5 =?1: 4=@5

*=

)7901:<401, =3;11 9;-6 09<1<

'98=;96 " % 72!52 # " 72!52 $ % 72!52 % " 72!52 & % 72!52 #" 72!52 %" 72!52 #"" 72!52 *1-8 $# *( #) )! "# #* ") !! * #! #+#! ! )! ! ! ,( "$ '' * ') ' *% * )# * $' #,%* " $! ! ! + )* & & & & & & & &

)7901:<401, =3;11 48=;-:1;4=981-6 09<1<

'98=;96 # " 72!52 % " 72!52 #" 72!52 #% 72!52 $" 72!52 $% 72!52 %" 72!52 #"" 72!52 *1-8 $# *( $( !! "( '! "$ !! ) )! & #! ! ! ! ,( "$ '' ) $% "# %! % )& & )& ( '' ! ! ! + )* & & & & & & & &

)7901:<401, =3;11 <>./>=-819>< 09<1<

'98=;96 # " 72!52 #" 72!52 #% 72!52 $" 72!52 $% 72!52 %" 72!52 &% 72!52 #"" 72!52 *1-8 $# *( $( !! "( '! "$ !! ) )! & #! ! ! ! ,( "$ '' ) $% "# %! % )& &,)& ( '' ! ! ! + )* & & & & & & & & !

,23

6VO^bS` .

6VO`OQbS`WaObW]\ ]T bVS QOZQWc[%UObSR O\R d]ZbOUS%RS^S\RS\b ^]bOaaWc[ QVO\\SZ F?B%) ]T \S[Ob]RSa O\R Wba W\bS`OQbW]\ eWbV S[]RS^aWRS

Fned^ ?)' ohg NZflhg(Cbff^elmc^kgZ B)' Hbeml\a N)H)' Rhelm^gahef^ <)E)' E^q <)M)' BZll^k M)=)' =Zee^lm^khl >)' B^Zkr O)B)' F^bl^k E)' Ohpglhg N)' CZk]^k <)' Fk{\d^g E)

Nn[fbmm^] mh KGhN KZmah`^gl 1NGVZKX +

. 6VO`OQbS`WaObW]\ ]T bVS QOZQWc[%UObSR O\R d]ZbOUS%RS^S\RS\b ^]bOaaWc[ QVO\\SZ F?B%) ]T \S[Ob]RSa O\R Wba W\bS`OQbW]\ eWbV S[]RS^aWRS

.&) 4Pab`OQb

Oa^ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^ Zg] bml iZk^gmZe \hfihng] KA,+--< Zk^ o^kr [khZ] li^\mknf g^fZmb\b]Ze ]kn`l pab\a Zk^ Z[e^ mh ^ebfbgZm^ g^fZmh]^l k^lblmZgm mh hma^k Zgma^efbgmb\l) Oa^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilb(i^imb]^l bl hger iZkmbZeer ng]^klmhh]' [nm bgoheo^l ma^ eZmkhiabebg G# XGZZO ) Oph iZkZeh`l p^k^ b]^gmb_b^] bg ma^ mkb\ah\^iaZeb]l ?# S[XOY ' ?# Y[OY Zg] ?# YVOXGROY ) N^o^kZe lieb\^ oZkbZgml ^g\h]bg` mkng\Zm^] \aZgg^el p^k^ b]^gmb_b^] bg ?XOIN[XOY lii) NGJ(, \aZgg^el h_ mkb\ah\^iaZeb]l _hkf Z fhghiare^mb\ `khni' lahpbg` maZm ]nieb\Zmbhg h\\nkk^] Z_m^k ma^ ]bo^k`^g\^ h_ @ghie^Z Zg] >akhfZ]hk^Z) Oh ^qiehk^ _ng\mbhg h_ Z k^ik^l^gmZmbo^ ikhm^bg' 1# KRKMGTY NGJ(, pZl ^qik^ll^] bg C# RGK\OY hh\rm^l Zg] lmn]b^] bg ^e^\mkhiarlbheh`b\Ze #ohemZ`^(\eZfi$ ^qi^kbf^gml) Dg\n[Zmbhg h_ hh\rm^l pbma ,(,+ H ^fh]^ilb]^ \Znl^] lb`gb_b\Zgmer bg\k^Zl^] \nkk^gml ho^k Z pb]^ kZg`^ h_ ahe]bg` ihm^gmbZel bg ma^ Z[l^g\^ h_ \Ze\bnf lb`gZeebg` ln``^lmbg` maZm ^fh]^ilb]^ ]bk^\mer hi^gl NGJ(,) @fh]^ilb]^ pZla hnm ]b] ghm k^o^kl^ ma^ ^__^\m Zg] ma^ NGJ(, bgab[bmhk o^kkn\neh`^g pZl hger ^__^\mbo^ pa^g Ziieb^] [^_hk^ [nm ghm Z_m^k ^fh]^ilb]^) Oa^ b]^gmb_b\Zmbhg h_ l^o^kZe lieb\^ oZkbZgml Zg] iZkZeh`l bg lhf^ iZkZlbmb\ g^fZmh]^l ln``^lml maZm ma^k^ Zk^ ln[lmZgmbZe ]b__^k^g\^l bg \aZgg^e ikhi^kmb^l Zfhg` li^\b^l) Hhlm bfihkmZgmer' mabl lmn]r lahp^] _hk ma^ _bklm mbf^ maZm ^fh]^ilb]^ ]bk^\mer hi^gl NGJ(, \aZgg^el' lb`gb_b\Zgmer bfikhobg` ma^ ng]^klmZg]bg` h_ ma^ fh]^ h_ Z\mbhg h_ mabl ]kn` \eZll)

,3+ 3SUJKVYOJK GTJ >8;"&

.&* <\b`]RcQbW]\

Dg @\]rlhshZ' eZk`^ \hg]n\mZg\^ ihmZllbnf \aZgg^el #Zelh =F hk HZqb(F \aZgg^el$ Zk^ ^g\h]^] [r YRU"& `^g^l gZf^] Z_m^k ma^ Ülehpihd^á ia^ghmri^ h[l^ko^] bg YRU"& ]^_b\b^gm 2# SKRGTUMGYZKX V,W) ?n^ mh ma^bk eZk`^ \hg]n\mZg\^ bg ma^ hi^g lmZm^' mrib\Zeer ^q\^^]bg` -++ iN' NGJ(, \aZgg^el Zk^ h_ fZchk bfihkmZg\^ _hk k^iheZkblZmbhg h_ ^q\bmZ[e^ \^eel ln\a Zl g^nkhgl' fnl\e^ \^eel Zg] ^qh\kbg^ Zl p^ee Zl ^g]h\kbg^ \^eel) Oa^l^ \aZgg^el Zk^ m^mkZf^kl Zg]' bg Zefhlm ^o^kr ZgbfZe li^\b^l' Zee ln[ngbml Zk^ ^g\h]^] [r Z lbg`e^ `^g^ Ö pbma m^e^hlm _bla Zl ma^ hger dghpg ^q\^imbhg' pbma fnembie^ YRU"& iZkZeh`l k^lnembg` _khf pahe^ `^ghf^ ]nieb\Zmbhgl V-W) Oa^ hi^gbg` h_ NGJ(, \aZgg^el bl \hgmkhee^] [r ma^ f^f[kZg^ ihm^gmbZe Zg] -& bgmkZ\^eeneZk _k^^ \Ze\bnf(\hg\^gmkZmbhgl V>Z Wb) ?^iheZkblZmbhg h_ ma^ f^f[kZg^ Zl p^ee Zl -& o^kr ab`a mkZglb^gm eh\Ze V>Z Wb Zk^ k^jnbk^] mh hi^g NGJ(, \aZgg^el V.W) Dg]^^]' Zm ma^ ln[\^eeneZk e^o^e' NGJ(, \heh\Zebl^l pbma ohemZ`^(`Zm^] \Ze\bnf \aZgg^el bg \Ze\bnf gZgh]hfZbgl' Zg] fbleh\ZeblZmbhg bgm^k_^k^l pbma bml _ng\mbhg bg 1# KRKMGTY V/W) Hhlm hma^k bhg \aZgg^el ikh]n\^ ln[mri^l pbma Zem^k^] iarlbheh`b\Ze ikhi^kmb^l makhn`a Z \hf[bgZmbhg h_ ]b__^k^gm ln[ngbml Zl k^\^gmer k^ob^p^] _hk Z\^mre\ahebg^ Zg] `enmZfZm^ k^\^imhkl V0'1W) Dg \hgmkZlm' l^o^kZe ]b__^k^gm YRU"& lieb\^ oZkbZgml aZo^ [^^g ]^l\kb[^] K#M# _hk 1# KRKMGTY ' 2# SKRGTUMGYZKX ' fb\^ Zg] anfZgl Zg] ]b__^k^gmbZe lieb\bg` bl dghpg mh Z__^\m \aZgg^e ikhi^kmb^l V2(,+W) Dg Z]]bmbhg' ma^ nl^ h_ ]b__^k^gm mblln^(li^\b_b\ ikhfhm^kl aZl [^^g ]^l\kb[^] _hk 2# SKRGTUMGYZKX V,,',-W) Dg]^^]' ma^ gnf[^k h_ ]b__^k^gm lieb\^ oZkbZgml aZl ]kZfZmb\Zeer bg\k^Zl^] ]nkbg` ^ohenmbhg' pab\a bl ]^fhglmkZm^] [r ma^ _Z\m maZm ma^ anfZg YRU"& hkmaheh` QITSG& ^g\h]^l ,. Zem^kgZmbo^ ^qhgl V,.W) Dg _Z\m' ma^ gnf[^k h_ lieb\^ oZkbZgml bg HZffZebZ Zg] ?bim^kZ bl lh ab`a maZm lrlm^fZmb\ ZgZerlbl h_ ma^ ^__^\ml h_ ma^ \aZgg^e oZkbZgml `^g^kZm^] [r Zem^kgZmbo^ lieb\bg` hg ohemZ`^( Zg] \Ze\bnf l^glbmbobmr aZl hger [^^g i^k_hkf^] _hk Z _^p h_ ma^f) Oa^ \hfie^qbmr h_ NGJ(, \aZgg^e a^m^kh`^g^bmr bl _nkma^k bg\k^Zl^] [r ma^ Z[bebmr mh _hkf a^m^khm^mkZf^kl V,/W \hgmZbgbg` ]b__^k^gm lieb\^ oZkbZgml Zg] ma^ _Z\m maZm \aZgg^e k^lihgl^l mh ]^iheZkblZmbhg Zg] \Ze\bnf Zk^ fh]neZm^] [r ihlmmkZgleZmbhgZe fh]b_b\Zmbhgl ln\a Zl iZefbmhreZmbhg Zg] iahliahkreZmbhg Zm l^o^kZe ]blmbg\m lbm^l V,0(,2W) Oa^ 1# KRKMGTY YRU"& `^g^ bl ^qik^ll^] bg ma^ iaZkrg`^Ze g^nkhgZe g^mphkd' bg fhmhg^nkhgl h_ ma^ ]hklZe Zg] o^gmkZe g^ko^ \hk] Zg] bg [h]r pZee fnl\e^l' [nm ghm bg iaZkrg`^Ze fnl\e^l V,3W) Nieb\^ oZkbZgml bg 1# KRKMGTY Zk^ fhk^ \e^Zker ZkkZg`^]' pbma _hnk ]b__^k^gm lieb\^ lbm^l `bobg` kbl^ mh ,- p^ee \aZkZ\m^kbl^] lieb\^ oZkbZgml V,4W ienl mak^^ Z]]bmbhgZe oZkbZgml ZgghmZm^] bg Rhkf=Zl^) @qik^llbhg e^o^el h_ ma^l^ oZkbZgml bg pahe^ 1# KRKMGTY Zl p^ee Zl

,3, 1NGVZKX + ohemZ`^ Zg] \Ze\bnf l^glbmbobmr ikh_be^l h_ ]b__^k^gm ahfhf^kb\ m^mkZf^kl aZo^ [^^g k^ihkm^] k^\^gmer V2',4W) Ra^ma^k ]b__^k^gmbZe lieb\bg` bl bg_en^g\^] [r ma^ \^ee( hk mblln^(mri^ #Zl lahpg _hk 2# SKRGTUMGYZKX $ Zg] pa^ma^k ma^ a^m^khf^kblZmbhg h_ ln[ngbml ^g\h]^] [r ]b__^k^gm lieb\^ oZkbZgml _nkma^k bg_en^g\^l ohemZ`^ Zg] \Ze\bnf l^glbmbobmr' Zk^ lmbee hi^g jn^lmbhgl) I^fZmh]^ NGJ(, \aZgg^el aZo^ k^\^bo^] iZkmb\neZk Zmm^gmbhg bg k^\^gm r^Zkl ]n^ mh ma^bk \^gmkZe bgoheo^f^gm bg ma^ fh]^ h_ Z\mbhg h_ ma^ [khZ](li^\mknf g^fZmb\b]Ze ]kn` ^fh]^ilb]^' Z \r\ehh\mZ]^ilbi^imb]^ V-+W) 1# KRKMGTY lmkZbgl pbma YRU"& ehll(h_(_ng\mbhg fnmZmbhgl Zk^ \hfie^m^er k^lblmZgm mh ^fh]^ilb]^ V-,W) @fh]^ilb]^ l^glbmbobmr \Zg [^ k^l\n^] [r k^(bgmkh]n\bg` NGJ(, ^qik^llbhg \Zll^mm^l h[mZbg^] _khf ^bma^k 1# KRKMGTY hk ma^ iZkZlbmb\ g^fZmh]^l /# IGTOT[S hk 1# UTIUVNUXG! [nm hger iZkmbZeer [r ma^ anfZg hkmaheh` V-,(-.W) Oa^l^ k^lneml \Zg [^ ^qieZbg^] [r ^bma^k Z ]bk^\m Zg] li^\b_b\ bgm^kZ\mbhg h_ ^fh]^ilb]^ pbma g^fZmh]^ NGJ(, \aZgg^el hk Z g^\^llZkr _ng\mbhg h_ NGJ(, bg Z lb`gZe mkZgl]n\mbhg iZmapZr ]hpglmk^Zf h_ Zg ^fh]^ilb]^ mZk`^m) @\mhib\ ^qik^llbhg h_ YRU"& bg ma^ iaZkrgq fnl\e^ bg Z YRU"& ]^_b\b^gm `^g^mb\ [Z\d`khng] \hg_^kk^] ^fh]^ilb]^ l^glbmbobmr mh iaZkrg`^Ze infibg` V-.W ln``^lmbg` maZm mabl \aZgg^e bl ^bma^k ma^ ]bk^\m mZk`^m h_ ma^ ]kn` hk maZm Zg ngb]^gmb_b^] mZk`^m bl ik^l^gm bg iaZkrg`^Ze fnl\e^ \^eel maZm bl Z\mboZm^] ]hpglmk^Zf h_ NGJ(,) ZXUTM_RUOJKY #\eZ]^ DQ$' # YZKXIUXGROY Zg] ?# ZXOINO[XG bl hger fh]^kZm^ mh

,3- 3SUJKVYOJK GTJ >8;"& ehp V.+W' Zemahn`a k^i^Zm^] ]hlbg` pZl ^__^\mbo^ bg Z ?# S[XOY fhnl^ fh]^e V.,W) Hhg^iZgm^e Zii^Zkl mh aZo^ `hh] ^__b\Z\r Z`Zbglm iZkZlbm^l _khf \eZ]^ Q' ^li^\bZeer bg lfZee knfbgZgml V.-W' Zemahn`a Z\mbobmr Z`Zbglm anfZg ahhdphkfl Zii^Zk^] mh [^ ebfbm^] V..W) Khhk hk gh ^__b\Z\r Z`Zbglm iZkZlbm^l _khf hma^k \eZ]^l pZl h[l^ko^] V..W) Ahk ># XGZZO mabl bl ik^lnfZ[er ]n^ mh ma^ _Z\m maZm gh f^f[^k h_ ma^ ?@B(.*?@N(- ln[_Zfber h_ <>aMl ^g\h]^] bg bml `^ghf^ V-2W) H^f[^kl h_ mabl ln[_Zfber Zk^ bfieb\Zm^] bg ma^ fhg^iZgm^e fh]^ h_ Z\mbhg bg \eZ]^ Q g^fZmh]^l V-3'./'.0W) Oa^l^ ^qZfie^l \e^Zker lahp maZm mk^f^g]hnl ]b__^k^g\^l ^qblm Zfhg` g^fZmh]^l k^`Zk]bg` lnl\^imb[bebmr mh Zgma^efbgmb\l' [Zl^] Zm e^Zlm bg iZkm hg ma^ ik^l^g\^ h_ Zgma^efbgmb\ mZk`^ml ^g\h]^] bg ma^bk `^ghf^l) ?^libm^ ma^bk k^eZmbo^er ngb_hkf [h]r laZi^' g^fZmh]^l Zk^ `^g^mb\Zeer Zg] iarlbheh`b\Zeer ^qmk^f^er ]bo^kl^ V.1'.2W) YRU"& `^g^l Zg] `^g^ ikh]n\ml aZo^ manl _Zk hger [^^g bgo^lmb`Zm^] bg \eZ]^ Q h_ ma^ iarenf I^fZmh]Z V-4W) Nbg\^ iZkZlbmb\ g^fZmh]^l h_ o^km^[kZm^l Zk^ _hng] bg _hnk h_ _bo^ \eZ]^l V-4W Zg] NGJ(, bl ZiiZk^gmer Z oZeb]Zm^] ]kn` mZk`^m' ma^ ik^l^gm lmn]r Zbf^] mh ZgZerl^ ma^ ]bo^klbmr h_ NGJ(, \aZgg^el pbmabg ma^ iarenf I^fZmh]Z Zg] mh ]^m^kfbg^ ^__^\ml h_ ^fh]^ilb]^ hg NGJ(, \aZgg^e hi^gbg` \aZkZ\m^kblmb\l)

,3. 1NGVZKX +

.&+ @ObS`WOZ O\R [SbV]Ra

Zk^

=:/ OYURGZOUT GTJ I2:/ Y_TZNKYOY I^fZmh]^l p^k^ ahfh`^gbs^] hg b\^ bg Okbshe #Dgobmkh`^g$ hk OkbAZlm #K^jeZ[$ k^Z`^gm nlbg` Z Oblln^Mnimhk Zg] mkZgliZk^gm ]blihlZ[e^ ikh[^l #LbZ`^g$) MI< pZl blheZm^] Z\\hk]bg` mh ma^ fZgn_Z\mnk^kâl bglmkn\mbhgl' ^q\^im maZm ma^ ohenf^ h_ Okbshe pZl bg\k^Zl^] mh 0 fe i^k ,++ f` p^m mblln^ p^b`am) Qhenf^l h_ Zee ln[l^jn^gmer nl^] k^Z`^gml p^k^ Z]cnlm^] Z\\hk]bg`er) MI ngmbe nl^) Ahk \?I< lrgma^lbl' , ` mhmZe MI< pZl fbq^] pbma ,++ iH h_ ^bma^k kZg]hf a^qZf^k ikbf^kl #_hk K>M pbma ]^`^g^kZm^ ikbf^kl$ hk heb`h ]O ikbf^kl #_hk _nee(e^g`ma K>Ml6 [hma ikbf^kl _khf Oa^kfh Abl\a^k N\b^gmb_b\$' bg\n[Zm^] Zm 10 |> _hk 0 fbg Zg] ma^g \abee^] hg b\^) M^o^kl^ mkZgl\kbimbhg pZl i^k_hkf^] bg -+ e nlbg` -++ P HZqbfZ M^o^kl^ OkZgl\kbimZl^ #Oa^kfh Abl\a^k N\b^gmb_b\$' , fH ]IOKl Zg] -+ P Mb[hGh\d Ä MIZl^ bgab[bmhk #Oa^kfh Abl\a^k N\b^gmb_b\$ [r bg\n[Zmbhg Zm /- |> _hk .+ fbg Zg] 1+ |> _hk .+ fbg) AbgZeer' ma^ ^gsrf^ pZl bgZ\mboZm^] Zm 2+ |> _hk 0

,3/ 3SUJKVYOJK GTJ >8;"& fbg)

/SVROLOIGZOUT UL L[RR"RKTMZN I2:/Y KZkmbZe `^ghfb\ ]ZmZ _khf ?# S[XOY Zg] ?# IGTOY Zg] Z ]^]n\^] _nee(e^g`ma l^jn^g\^ h_ ># XGZZO #_hk iareh`^g^mb\ ZgZerlbl hger$ p^k^ ikhob]^] [r ma^ KZkZlbm^ B^ghfb\l `khni Zm ma^ R^ee\hf^ Oknlm NZg`^k Dglmbmnm^ #ppp)lZg`^k)Z\)nd*k^l^Zk\a*ikhc^\ml*iZkZlbm^`^ghfb\l*$) =Zl^] hg \hfiZkblhgl Zfhg` ZoZbeZ[e^ leh(, \?I< l^jn^g\^l h_ 6# IUTZUXZ[Y ' 1# UTIUVNUXG Zg] 1# KRKMGTY! ]^`^g^kZm^ ikbf^kl p^k^ ]^lb`g^] Zg] nl^] mh Zfieb_r Zg] l^jn^g\^ lfZee leh(, _kZ`f^gml h_ <# KW[UX[S Zg] /# Y[[S ) < ,-1 [i ehg` \?I< l^jn^g\^ h_ ?# IGTOY leh(, in[ebla^] hg g^fZmh]^)g^m V/+W pZl b]^gmb_b^] [r =G@ K>M p^k^ ]^lb`g^] nlbg` ma^l^ l^jn^g\^ ]ZmZ) K>Ml \hgmZbg^] +). fH ]IOKl' +)/ H h_ ma^ `^g^(li^\b_b\ Zg] ma^ ngbo^klZe ikbf^k' , e \?I< Zg] +)0 e <]oZgmZ`^ Ä - Kherf^kZl^ Hbq #>ehgm^\a$ bg -0 e , !<]oZgmZ`^ [n__^k) Anee(e^g`ma l^jn^g\^l p^k^ Zfieb_b^] nlbg` mph `^g^(li^\b_b\ ikbf^kl Zg] ma^ lZf^ K>M ikhmh\he) K>M _kZ`f^gml p^k^ `^e inkb_b^]' \ehg^] bgmh i>M/ OJKJ #Dgobmkh`^g$ Zg] l^gm mh B =bhm^\a _hk l^jn^g\bg`) Kkbf^kl _hk Zee _nee(e^g`ma Zfieb_b\Zmbhgl Zk^ ikhob]^] bg Nniie^f^gmZkr OZ[) 1(-) Ahk hma^k g^fZmh]^l' ikbf^kl ]^kbo^] _khf iZkmbZe leh(, l^jn^g\^l b]^gmb_b^] bg ma^ ?# S[XOY ' 2# OSSOZOY ' ;TINUIKXIG \UR\[R[Y Zg] 0# SGRG_O `^ghf^ ikhc^\ml p^k^ nl^]) Plbg` ma^l^ l^jn^g\^l' ikbf^kl _hk 0"( Zg] ."( M<>@ K>M p^k^ ]^lb`g^] Zg] M<>@ K>Ml p^k^ \Zkkb^] hnm pbma ma^ 0"*." M<>@ Fbm #l^\hg] `^g^kZmbhg$ Zl ]^mZbe^] ik^obhnler V.4W) K>Ml p^k^ i^k_hkf^] bg -0 e , !Kanlbhg DD [n__^k \hgmZbgbg` , P Kanlbhg DD ?I< iherf^kZl^ #Oa^kfh Abl\a^k$' +). fH ]IOKl' +). H h_ ^Z\a ikbf^k' , !L lhenmbhg #LbZ`^g$ Zg] , e \?I< lrgma^lbl^] pbma M^o^km,+++ hk N,+++ \r\e^k pbma bgbmbZe ]^gZmnkZmbhg Zm 43 |> _hk , fbg _heehp^] [r .0 \r\e^l pbma ]^gZmnkZmbhg Zm 43 |> _hk ,+ l' Zgg^Zebg` Zm Z ikbf^k iZbk li^\b_b\ m^fi^kZmnk^ _hk .+ l Zg] ^ehg`Zmbhg Zm 2- |> _hk -+ l mh - fbg) Ahk _nee(e^g`ma K>Ml' ikbf^kl _eZgdbg` ma^ hi^g k^Z]bg` _kZf^ p^k^ \ahl^g) Anee(e^g`ma ikbf^kl _hk 0# SGRG_O ' 2# OSSOZOY Zg] ;# M[ZZ[XUYG p^k^ h[mZbg^] _khf `^ghf^ ]ZmZ V/,W) Ankma^k ]^mZbel Z[hnm ikbf^k l^jn^g\^l Zg] K>M \hg]bmbhgl Zk^ ZoZbeZ[e^ bg Nniie^f^gmZkr OZ[) 1(-) K>M ikh]n\ml p^k^ `^e(inkb_b^] Zg] \ehg^] bgmh i>M/ OJKJ [engm o^\mhk Zg] l^jn^g\^] [r B =bhm^\a)

,30 1NGVZKX +

7JKTZOLOIGZOUT UL VXUZKOT SUZOLY OT >8;"& INGTTKRY Hhe^\neZk p^b`am Zg] inmZmbo^ blh^e^\mkb\ ihbgml p^k^ \Ze\neZm^] pbma >ehg^ HZg`^k 4 #N\b^gmb_b\ Zg] @]n\ZmbhgZe Nh_mpZk^$) Gh\ZeblZmbhg h_ mkZglf^f[kZg^ k^`bhgl pZl ik^]b\m^] nlbg` OHKk^] lh_mpZk^ V/-W) >hgl^ko^] ]hfZbgl Zg] Kkhlbm^ fhmb_l p^k^ b]^gmb_b^] nlbg` >?(=G

# XGZZO #h[mZbg^] _khf ma^ NZg`^k `^ghf^ ikhc^\m$) ?^]n\^] ikhm^bg l^jn^g\^l p^k^ Zeb`g^] nlbg` >enlmZeS- V/4W)

3^VKXOSKTZGR JKZKIZOUT UL JOLLKXKTZOGR YVROIK VXUJ[IZY Oa^ ikbf^kl _eZgdbg` ma^ inmZmbo^ lieb\^ lbm^ #Nniie^f^gmZkr OZ[) 1(-$ p^k^ nl^] bg Z mph( lm^i MO(K>M Zl ]^l\kb[^] Z[ho^) K>M ikh]n\ml p^k^ ZgZerl^] hg -)+ Z`Zkhl^ `^el Zg] pbma ma^ ?I< ,+++ dbm hg ma^ =bhZgZers^k -,++ #<`be^gm$) B^e(inkb_b^] ?I< _kZ`f^gml p^k^ \ehg^] Zg] l^jn^g\^]) LnZgmb_b\Zmbhg h_ _kZ`f^gml pZl i^k_hkf^] nlbg` ma^ =bhZgZers^k @qi^km lh_mpZk^)

,31 3SUJKVYOJK GTJ >8;"&

?XOIN[XOY Y[OY ZXGTYIXOVZUSK JGZG Ahk MI<(l^j ^qi^kbf^gml' mhmZe MIM(Zfieb_b^] #,0 \r\e^l$ Zl k^\hff^g]^] Zg] inkb_b^] hg Hbg@enm^ \henfgl #LbZ`^g$) AbgZeer' eb[kZkb^l p^k^ ln[c^\m^] mh iZbk^](^g] MI<(l^j nlbg` CbN^j -+++ #DeenfbgZ$ Zg] Zll^ll^] _hk jnZebmr Zg] Z]Zim^k l^jn^g\^l) <_m^k l^jn^g\bg`' kZp k^Z]l p^k^ mkbff^] h_ DeenfbgZ Z]Zim^kl' _bem^k^] _hk e^g`ma # * /+ gn\e^hmb]^l$ Zg] ehp(jnZebmr ]ZmZ #k^Z]l \hgmZbgbg` _hnk hk fhk^ \hgl^\nmbo^ [Zl^l lahpbg` Z KCM@? jnZebmr [^ehp -+$) OkZgl\kbiml _hk ^Z\a lmZ`^ Zg]*hk [h]r ihkmbhg Zl p^ee Zl ma^ DeenfbgZ MI<(l^j ]ZmZ _khf Z fbq^](l^q Z]nem ?# Y[OY mkZgl\kbimhf^ `^g^kZm^] ik^obhnler V01W p^k^ k^\hglmkn\m^] Zg] jnZgmb_b^] [r E^q KZ GR# #ngin[ebla^] ]ZmZ$ nlbg` ma^ Onq^]h lnbm^ V02W Zg] Z ]kZ_m Zll^f[er h_ ma^ ?# Y[OY `^ghf^ #E^q KZ GR# ' ngin[ebla^]$) ?b__^k^gmbZe mkZgl\kbimbhg pZl Zll^ll^] nlbg` IJDN^j V03W pbma -+ h_ ma^ ^oZenZm^] k^Z]l _hk ^Z\a eb[kZkr nl^] bg 0 bm^kZmbhgl mh lbfneZm^ m^\agb\Ze k^ieb\Zm^l #ghm^5 Zee MI<(l^j eb[kZkb^l p^k^ \hglmkn\m^] _khf fnembie^ iZkZlbm^l' O#K#! ,+ Z]neml hk 0+'+++ eZkoZ^ k^mkb^o^] _khf fnembie^ ahlm bg]bob]nZel mh \hfi^glZm^ _hk bgm^k( bg]bob]nZe [bheh`b\Ze oZkbZmbhg$)

M/OJKJ #Dgobmkh`^g$ p^k^ nl^]) KeZlfb] ?I< pZl ebg^Zkbl^] bg ,++ e , ![n__^k \hgmZbgbg` 3 ` ieZlfb] ?I< Zg] ,++ P S[ZD #_hk 1# KRKMGTY NGJ(,Z$ hk ,++ P =\nD #_hk ?# S[XOY NGJ( ,),Z$ Zm .2 |> _hk - a) Gbg^Zkbl^] ieZlfb] ?I< pZl inkb_b^] obZ ma^ B^g^E^m K>M Knkb_b\Zmbhg dbm #Oa^kfh Abla^k N\b^gmb_b\$ Zg] ^enm^] pbma 0+ e PemkZKnk^ ?IZl^*MIZl^(_k^^ ]blmbee^] pZm^k) Gbg^ZkblZmbhg h_ ma^ ieZlfb] ?I< pZl fhgbmhk^] [r Z`Zkhl^ `^e ^e^\mkhiahk^lbl) ?I< \hg\^gmkZmbhg pZl ]^m^kfbg^] nlbg` ma^ ?I< ,-+++ dbm Zg] ma^ -,++

,32 1NGVZKX +

=bhZgZers^k #<`be^gm O^\agheh`b^l$) Ahk \MI< lrgma^lbl' ma^ fH^llZ`^ fHZ\abg^ O2 mkZgl\kbimbhg dbm #

9OIXUOTPKIZOUT UL C# RGK\OY UUI_ZKY ?^_heeb\neZm^] C# RGK\OY hh\rm^l p^k^ h[mZbg^] _khf @\h>rm^ =bhl\b^g\^ #>Zlmkhi(MZnq^e' B^kfZgr$) <_m^k ]^ebo^kr' lbg`e^ hh\rm^l p^k^ mkZgl_^kk^] bgmh bg]bob]nZe \Zobmb^l h_ Z /3 p^ee ieZm^ \hgmZbgbg` =Zkmaâl lhenmbhg #33 fH IZ>e' - fH F>e' , fH H`>e -' ,0 fH Okbl C>e'

+)0 fH >Z>e -' iC 2)/$ Zg] bg\n[Zm^] _hk Zm e^Zlm - a Zm ,4 |> [^_hk^ nl^) 20 ge h_ ^bma^k -++ g`* G 1# KRKMGTY NGJ(,Z \MI< hk ?# S[XOY NGJ(,),Z p^k^ fb\khbgc^\m^] bgmh ^Z\a hh\rm^ nlbg` ma^ Mh[hbgc^\m #Hnemb >aZgg^e Nrlm^fl H>N Bf[C$) Jh\rm^l bgc^\m^] pbma 20 ge pZm^k l^ko^] Zl g^`Zmbo^ \hgmkhe) Khlbmbhg h_ bfiZe^f^gm pZl l^m mh .0+ f' pa^k^Zl ihlbmbhg h_ bgc^\mbhg pZl l^m mh /++ f) Jh\rm^l p^k^ bg\n[Zm^] Zm ,4 |> _hk .(/ ]Zrl ihlm fb\khbgc^\mbhg) =Zkmaâl lhenmbhg pZl k^ieZ\^] ]Zber)

AURZGMK IRGSV K^VKXOSKTZY ]OZN C# RGK\OY UUI_ZKY @qi^kbf^gml p^k^ \Zkkb^] hnm nlbg` ma^ Mh[hh\rm^ #Hnemb >aZgg^e Nrlm^fl H>N Bf[C$) Dg ma^ Mh[hh\rm^' hh\rm^l p^k^ i^k_nl^] pbma ghkfZe _kh` Mbg`^k lhenmbhg #IAM5 4+ fH IZ>e'

- fH F>e' - fH >Z>e -' , fH H`>e -' 0 fH C@K@N' iC 2)/$ _hk , fbg [^_hk^ ^e^\mkh]^l p^k^ bgl^km^] Zg] f^f[kZg^ ihm^gmbZe pZl \eZfi^] mh (2+ fQ) @qi^kbf^gml p^k^ \Zkkb^] hnm Zl lnffZkbl^] bg Ab`) 1(,) Dg `^g^kZe' DQ>l p^k^ k^\hk]^] Z_m^k Zghma^k i^k_nlbhg _hk , fbg) >nkk^gml p^k^ k^\hk]^] ]nkbg` \eZfibg` ma^ f^f[kZg^ ihm^gmbZe [^mp^^g (,-+ Zg] &1+ fQ _hk 0++ fl nlbg` ohemZ`^ lm^il h_ -+ fQ #Ab`) 1(,=$) =^mp^^g bg]bob]nZe lm^il' ma^ f^f[kZg^ ihm^gmbZe pZl \eZfi^] mh (2+ fQ _hk . l) <_m^k bgbmbZe k^\hk]bg`l h_ DQ>l' Z i^k_nlbhg pbma IAM pZl i^k_hkf^] _hk - fbg [^_hk^ k^i^Zmbg` ma^ k^\hk]bg` mh ^glnk^ maZm k^lihgl^l p^k^ lmZ[e^ ho^k mbf^ #Ab`) 1(,<#D$$) Jh\rm^l lahpbg` \nkk^gml ^q\^^]bg` -0+ g< Zm &1+ fQ p^k^ ^q\en]^] _khf _nkma^k ^qi^kbf^gml) Oh ]^m^kfbg^ ma^ ^__^\ml h_ ]kn`l' hh\rm^l p^k^ _bklm bg\n[Zm^] pbma ma^ o^ab\e^ #+), ?HNJ' +)++. Kenkhgb\ A(13 #Nb`fZ l p^k^ k^\hk]^] Zg] hh\rm^l p^k^ Z`Zbg i^k_nl^] _hk , fbg [^_hk^ bg\n[Zmbhg pbma ^fh]^ilb]^ Zg] Zghma^k k^\hk]bg` #Ab`) 1(,Z#DD$$) Oh m^lm pa^ma^k ihm^gmbZe ^fh]^ilb]^ ^__^\ml p^k^ k^o^klb[e^' hh\rm^l p^k^ i^k_nl^] _hk 0 mh ,+ fbg pbma IAM Z_m^k Zg DQ> k^\hk]bg` bg ma^ ik^l^g\^ h_ ^fh]^ilb]^ #Ab`) 1(,< #DDD$' #DQ$$) @__^\ml h_ ma^ [eh\d^k o^kkn\neh`^g #, H$ p^k^ ]^m^kfbg^] [hma [^_hk^ Zg] Z_m^k Z]]bmbhg h_ ^fh]^ilb]^ #, H$ mh

,33 3SUJKVYOJK GTJ >8;"& ma^ hh\rm^l #Ab`) 1(,< #Q$' #QD$$) >nkk^gml p^k^ k^\hk]^] nlbg` Mh[hh\rm^ >eZfi

9WU& .%)& ?^l\kbimbhg h_ ma^ ^e^\mkhiarlbheh`b\Ze k^\hk]bg`l Dg]bob]nZe hh\rm^l p^k^ bgbmbZeer m^lm^] bg ma^ Z[l^g\^ h_ ]kn`l k^i^Zm^]er mh ^glnk^ maZm hh\rm^ k^lihgl^l p^k^ lmZ[e^ ho^k mbf^ #Ab`) 1(,< #b$$) >nkk^gm(ohemZ`^ \nko^l #DQ>l$ p^k^ k^\hk]^] Z_m^k \eZfibg` ma^ f^f[kZg^ ihm^gmbZe mh (2+ fQ) Oa^g' ahe]bg` ihm^gmbZel p^k^ \eZfi^] _khf (,-+ fQ mh &1+ fQ bg -+ fQ lm^il pbma . l Zm (2+ fQ [^mp^^g bg]bob]nZe ohemZ`^ lm^il Zl lahpg bg Ab`) ,=) Oa^ o^ab\e^ \hgmZbg^] +), ?HNJ Zg] +)++. Kenkhgb\ A(13) ?kn`l Zg] o^ab\e^ p^k^ Z]]^] fZgnZeer bg ma^ Z[l^g\^ h_ i^k_nlbhg) @fh' ^fh]^ilb]^6 Q>' o^kkn\neh`^g6 IAM' ghkfZe _kh` kbg`^k)

>ZGZOYZOIGR GTGR_YOY UL KRKIZXUVN_YOURUMOIGR JGZG H^Zg \nkk^gml ]nkbg` ^Z\a ohemZ`^ lm^i p^k^ \Ze\neZm^] _hk bg]bob]nZe hh\rm^l bg Mh[hh\rm^ >eZfil' f^Zg \nkk^gml É N@H _hk Zee k^ieb\Zm^ hh\rm^l p^k^ iehmm^] Z`Zbglm ma^ ohemZ`^ nl^] mh \eZfi ma^ f^f[kZg^ ihm^gmbZe bg BkZiaKZ] Kkblf 1)++) H^Zg \nkk^gml [^mp^^g ]b__^k^gm `khnil h_ hh\rm^l p^k^ \hfiZk^] l^iZkZm^er _hk ^o^kr ahe]bg` ihm^gmbZe Ziieb^] nlbg` ma^ fnembie^ m(m^lm _ng\mbhg bg BkZiaKZ] Kkblf) < oZen^l p^k^ \hkk^\m^] _hk fnembie^ \hfiZkblhgl nlbg` ma^ Chef(Nb]Zd f^mah])

,34 1NGVZKX +

.&, ESacZba

1USVGXOYUT UL YRU"& I2:/Y GTJ KTIUJKJ VXUZKOTY Nniie^f^gmZkr OZ[) 1(. lnffZkbl^l ma^ iarlb\h(\a^fb\Ze ikhi^kmb^l h_ ik^]b\m^] g^fZmh]^ NGJ(, ln[ngbml \hfiZk^] mh ahfheh`hnl ikhm^bgl _khf hma^k g^fZmh]^l Zg] lhf^ hkmaheh`l _khf hma^k li^\b^l nl^] Zl hnm`khni bg _nkma^k iareh`^g^mb\ ZgZerlbl) Jger Z lbg`e^ _nee(e^g`ma \?I< l^jn^g\^ pZl b]^gmb_b^] _khf \eZ]^ DDD g^fZmh]^l # 0# SGRG_O ' ;# M[ZZ[XUYG ' <# KW[UX[S ' /# Y[[S Zg] ?# IGTOY $' Zemahn`a Zem^kgZmbo^ ^qhgl p^k^ b]^gmb_b^] bg iZkmbZe K>M ikh]n\ml #]ZmZ ghm lahpg$) Oa^l^ l^jn^g\^l p^k^ ghm bg\en]^] bg ma^ bgbmbZe ZgZerlbl h_ ]b__^k^gmbZe lieb\bg` lbg\^ gh bg_hkfZmbhg k^`Zk]bg` ihllb[e^ \hf[bgZmbhgl h_ ]b__^k^gm ^qhgl bl \nkk^gmer ZoZbeZ[e^ _hk ma^f) Ahk 0# SGRG_O ' lbq ]b__^k^gm blh_hkfl # 0SG NGJ(,\(a$ Zk^ ZgghmZm^] bg Rhkf=Zl^ Zg] blh_hkf 0SG NGJ(,_ pZl b]^gmb\Ze mh ma^ hg^ b]^gmb_b^] bg ma^ ik^l^gm lmn]r #Ab`) 1(-$) Ahk 2# OSSOZOY mph oZkbZgml p^k^ b]^gmb_b^] ]b__^kbg` hger bg Z lahkm k^`bhg ^g\h]bg` Zfbgh Z\b]l 123(14- bg 2OS NGJ(,Z' pab\a bl fbllbg` bg 2OS NGJ(,[ #Ab`) 1(-$) Dg ma^ \eZ]^ D g^fZmh]^ ?# S[XOY ' mph iZkmbZe `^ghfb\ l^jn^g\^l ^g\h]bg` NGJ(, ahfheh`l p^k^ b]^gmb_b^] bg \hgmb`l IJ?@X,040-Xe^g`maX03-0X\hoX,+)2-//1. Zg] IJ?@X,../,2Xe^g`maX-.,//X\hoX,,)/-20/,) Anee(e^g`ma \?IhfiZkblhg pbma ?# YVOXGROY l^jn^g\^l bg B^g=Zgd k^o^Ze^] maZm mabl \eZ]^ D g^fZmh]^ Zelh ^g\h]^l mph ]blmbg\m NGJ(, ahfheh`l bg bml `^ghf^) Oa^ ?# YVOXGROY NGJ(,), ikhm^bg l^jn^g\^ \Zg [^ _hng] Zl mph iZkmbZe ^gmkb^l' pab\a \ho^k ma^ pahe^ e^g`ma ng]^k ma^ B^g=Zgd Z\\^llbhg gnf[^kl SKX++..2+-2.), Zg] SKX++..2+-2/) Oa^ ?# YVOXGROY NGJ(,)- ]ZmZ[Zl^ ^gmkb^l SKX++..2+-2+),' SKX++..2+-2,), Zg] SKX++..2+-2-), \hkk^lihg] mh ma^ ?# S[XOY NGJ(,)-) Dg [hma mkb\ah\^iaZeb]l' ma^ mph iZkZeh`l Zk^ cnqmZihl^] bg ma^ `^ghf^ bg Z mZbe(mh(mZbe hkb^gmZmbhg) Oph lieb\^ oZkbZgml ^g\h]bg` _nee(e^g`ma ?# S[XOY NGJ(,), \aZgg^el p^k^ b]^gmb_b^]) Dg Z]]bmbhg' mph lieb\^ oZkbZgml ^g\h]bg` l^o^k^er mkng\Zm^] ikhm^bgl p^k^ \ehg^]6 mkng\Zmbhg bl \Znl^] [r k^m^gmbhg h_ Z iZkmbZe hk ^gmbk^ bgmkhg bg ma^ fZmnk^ MI<' e^Z]bg` mh ik^fZmnk^ lmhi \h]hgl # ?S[ NGJ,),\ Zg] ?S[ NGJ(,),] bg Ab`) 1(-' k^li^\mbo^er$)

,4+ 3SUJKVYOJK GTJ >8;"&

,4, 1NGVZKX +

9WU& .%*& >hfiZkblhg h_ NGJ(, lieb\^ oZkbZgml bg g^fZmh]^l N\a^fZmb\ k^ik^l^gmZmbhgl h_ ]b__^k^gm lieb\^ oZkbZgml ZgghmZm^] bg Rhkf=Zl^ _hk 1# KRKMGTY #1KR NGJ(,Z(f' r' s$ Zg] 0# SGRG_O # 0SG NGJ(,\(a$ bg \hfiZkblhg pbma oZkbZgml b]^gmb_b^] bg _nee(e^g`ma \?I' eh\Zm^] bff^]bZm^er [^_hk^ Zem^kgZmbo^ lieb\^ k^`bhg /' Zk^ ]^ib\m^] Zl mabg o^kmb\Ze ebg^l)

Plbg` ikbf^kl _eZgdbg` ma^l^ bgmkhgl' Z l^fb(jnZgmbmZmbo^ ^lmbfZm^ h_ ma^ _k^jn^g\r h_ ma^ lieb\^ oZkbZgml pZl ihllb[e^ bg mph bg]^i^g]^gm ?# S[XOY blheZm^l) K>M ikh]n\ml p^k^ l^iZkZm^] hg Z`Zkhl^ `^el #Ab`) 1(.<$ Zg] ma^ =bhZgZers^k #Ab`) 1(.=$) Oa^ eZmm^k pZl nl^] mh jnZgmb_r ma^ Zfhngm h_ ?I< bg ma^ i^Zdl #OZ[) 1(,$) Dg \hgmkZlm mh ma^ bgbmbZe bfik^llbhg _khf Z`Zkhl^ `^el' pa^k^ ma^ eZk`^ K>M ikh]n\ml ^g\h]bg` ma^ mkng\Zm^] o^klbhgl ikh]n\^] ma^ [kb`am^lm [Zg]l' ma^ =bhZgZers^k \e^Zker lahpl maZm ma^ lfZee^lm _kZ`f^gm ^g\h]bg` _nee(e^g`ma \aZgg^el k^ik^l^gml ma^ fZchkbmr h_ Zfieb\hgl bg m^kfl h_ fhe^\ne^l #22 Zg] 3/ $)

GOP& .%)& M^eZmbo^ Z[ng]Zg\^ h_ \?I< Zfieb\hgl ^g\h]bg` _nee(e^g`ma hk mkng\Zm^] ?# S[XOY NGJ(, \aZgg^el

?# S[XOY blheZm^5 Hhga^bf @]bg[nk`a Uhh (MO \hgmkhe gh Zfieb\hg gh Zfieb\hg B^ghfb\ K>M .0. [i ,++ É +)+ .0. [i ,++ É +)+ MO(K>M 12 [i 22)1 É +)1 12 [i 3.)3 É +)/ ,3+ [i 2)3 É +)/ ,3+ [i /)0 É ,)2 .0. [i ,-)2 É +)1 .0. [i ,,)1 É -)+

,4- 3SUJKVYOJK GTJ >8;"&

9WU& .%+& @lmbfZmbhg h_ lieb\^ oZkbZgm Z[ng]Zg\^l ^g\h]^] mkng\Zm^] hk _nee(e^g`ma o^klbhgl h_ ?# S[XOY NGJ(,),)

<$ Kkbf^kl _eZgdbg` ma^ bgmkhgl k^mZbg^] bg ma^ \?IM #eZg^l ,' -' 0' Zg] 1$ Zg] `^ghfb\ K>M #eZg^l / Zg] 3$) O^fieZm^ pZl ^bma^k ]^kbo^] _khf ma^ Hhga^bf #eZg^l ,(/$ hk ma^ @]bg[nk`a Uhh #eZg^l 0(3$ blheZm^) GZg^l . Zg] 2 lahp gh k^o^kl^ mkZgl\kbimbhg \hgmkhel) H' ,++ [i eZ]]^k) =$ M^ik^l^gmZmbo^ lZfie^l l^iZkZm^] hg ma^ =bhZgZers^k) Oa^ nii^k iZg^e lahpl Z `^ghfb\ K>M ikh]n\m' ma^ fb]]e^ iZg^e ma^ \hgmkhe pbmahnm k^o^kl^ mkZgl\kbimbhg Zg] ma^ [hmmhf iZg^e ma^ MO(K>M)

Oh k^o^Ze b_ ma^l^ mkng\Zm^] \aZgg^e o^klbhgl Zk^ ik^l^gm bg k^eZm^] li^\b^l' ngin[ebla^] ]ZmZ _khf Z ?# Y[OY `^ghf^*mkZgl\kbimhf^ ikhc^\m p^k^ ZgZerl^] _hk ma^ ik^l^g\^ h_ ]b__^k^gm leh(, lieb\^ ikh]n\ml) Okng\Zm^] o^klbhgl ]n^ mh k^mZbg^] bgmkhgl p^k^ h[l^ko^] bg [hma ?Y[ NGJ(,), Zg] ?Y[ NGJ(,)- bg ma^ lZf^ k^`bhg h_ ma^ \aZgg^e # O#K#! ma^ mkZglf^f[kZg^ a^ebq N/ Zg] ma^ ohemZ`^ l^glhk \hfikbl^] h_ N0 Zg] N1$' [nm ma^ bgmkhgl bgoheo^] bg ma^l^ ^o^gml p^k^ ghm Zm ^qZ\mer ma^ lZf^ ihlbmbhg) M^fZkdZ[er' Zem^kgZmbo^ ^qhgl p^k^ _hng] bff^]bZm^er [^_hk^ ma^ k^mZbg^] bgmkhgl' pbma hg^ lieb\^ oZkbZgm hger ik^l^gm Zfhg` \?I

9WU& .%,& Ak^jn^g\b^l h_ ?# Y[OY leh(, lieb\^ oZkbZgml \hfiZkbg` ]^o^ehif^gmZe lmZ`^l' ]b__^k^gm l^q^l Zg] mblln^l

Ak^jn^g\b^l h_ lieb\^ oZkbZgml bg m^kfl h_ _kZ`f^gml i^k dbeh[Zl^ h_ ^qhgl i^k fbeebhg _kZ`f^gml fZii^] #AFKH$) Gb[kZkb^l p^k^ \hfiZk^] Z\\hk]bg` mh ]^o^ehif^gmZe lmZ`^ #< Zg] >$ Zl p^ee Zl ]b__^k^gm l^q^l hk mblln^l #= Zg] ?$) Nieb\^ oZkbZgml p^k^ `khni^] Z\\hk]bg` mh ma^ ^g\h]^] ikhm^bg' O#K# _k^jn^g\b^l h_ lieb\^ oZkbZgml ^g\h]bg` ma^ lZf^ ikhm^bg Zg] ]b__^kbg` bg l^jn^g\^ ]hpglmk^Zf h_ ma^ lmhi \h]hg p^k^ Z]]^] mh`^ma^k) <$ Zg] =$ lahp ^qik^llbhg iZmm^kgl h_ ?Y[ leh(,), pa^k^Zl >$ Zg] ?$ bg]b\Zm^ iZmm^kgl _hk ?Y[ leh(,)- lieb\^ oZkbZgml) HZe)' fZe^l' HZe) ihlm)' ihlm^kbhk iZkm h_ fZe^l6 A^f) A^fZe^l6 A^f) ihlm)' ihlm^kbhk iZkm h_ _^fZe^l6 Nmb\a)' lmb\ahlhf^)

,4/ 3SUJKVYOJK GTJ >8;"&

LnZgmbmZmbo^ ZgZerlbl h_ mkZgl\kbimhf^ ]ZmZ k^o^Ze^] _hk ?Y[ leh),), maZm ma^ fhlm Z[ng]Zgmer ]^m^\m^] lieb\^ oZkbZgm \hkk^lihg]l mh ma^ _nee(e^g`ma lieb\^ oZkbZgm ?Y[ leh(,),)/ bg m^kfl h_ _kZ`f^gml i^k dbeh[Zl^ h_ ^qhgl i^k fbeebhg _kZ`f^gml fZii^] #AFKH$' pa^k^Zl ma^ hma^k _nee(e^g`ma oZkbZgm ?Y[ leh,),)2 pZl _hng] Zm fn\a ehp^k Z[ng]Zg\^ #Ab`) 1(/$) Oa^ l^\hg] fhlm Z[ng]Zgmer ]^m^\m^] lieb\^ oZkbZgm # ?Y[ leh,),),+$ ^g\h]^l Z l^o^k^er mkng\Zm^] ikhm^bg h_ lbfbeZk e^g`ma Zl ma^ mkng\Zm^] ?# S[XOY oZkbZgml ]^m^\m^] [r MO(K>M #Ab`) 1(-$) M^fZkdZ[er' ma^k^ Zk^ o^kr h[obhnl ]b__^k^g\^l bg _k^jn^g\r h_ lieb\^ oZkbZgml' Zemahn`a ma^l^ ]b__^k^g\^l \hne] ghm [^ ^oZenZm^] lmZmblmb\Zeer lbg\^ hger Z lbg`e^ eb[kZkr pZl l^jn^g\^] i^k lmZ`^ hk mblln^) Ahk ^qZfie^' ma^ _k^jn^g\r h_ ?Y[ leh(,),),+ kZg`^] [^mp^^g -+ bg Z]neml Zg] .0 bg G,' pbma G. Zg] G/ lahpbg` bgm^kf^]bZm^ _k^jn^g\b^l #Ab`) 1(/<$) <]]bmbhgZe lmZ`^ li^\b_b\ lieb\bg` bl ^q^fieb_b^] [r ma^ \aZgg^el ^g\h]^] [r ?Y[ leh(,),)-*0*,/ Zg] ?Y[ leh(,),).5 Rabe^ ma^ _hkf^k ^g\h]^l Z \aZgg^e o^kr lbfbeZk mh ?Y[ leh(,),),+' [nm ]b__^kbg` bg bml IC - m^kfbgnl' ma^ eZmm^k oZkbZgm bl ^qmk^f^er mkng\Zm^] #Ab`) 1(-$) IhmZ[er' ma^ Z[ng]Zg\^ h_ ?Y[ leh(,),),+ bl k^eZmbo^er ab`a Zfhg` leh(,), mkZgl\kbiml ]nkbg` eZkoZe ]^o^ehif^gm' i^Zdbg` bg ma^ G,*G- lmZ`^ #Ab`) 1(/<$) Dg \hgmkZlm' mkZgl\kbimbhg h_ mabl ab`aer mkng\Zm^] leh(,), lieb\^ oZkbZgm pZl k^eZmbo^er ehp #lmZmblmb\Zeer lb`gb_b\Zgm Zm Z _Zel^ ]bl\ho^kr kZm^ h_ +),$ bg fhlm Z]nem eb[kZkb^l' pbma ma^ fZchk ^q\^imbhg [^bg` ma^ lmb\ahlhf^' bg pab\a bm ]blieZr^] bml ab`a^lm Z[ng]Zg\^) Jma^k fbghk leh(,), blh_hkfl' bg\en]bg` fbghk leh(,), oZkbZgml' lahp^] ^ob]^g\^ h_ ]b__^k^gmbZe mkZgl\kbimbhg ]nkbg` ]^o^ehif^gm Zg] bg Z]nemahh] Zfhg` `^g]^kl*mblln^l) Chp^o^k' [^\Znl^ lbg`e^ eb[kZkr k^ieb\Zm^l p^k^ nl^] _hk ^Z\a mblln^ Zg] lmZ`^ h_ ?# Y[OY ' lmZmblmb\Ze Zll^llf^gm h_ ma^ ]b__^k^gmbZe mkZgl\kbimbhg h_ ma^l^ fbghk blh_hkfl bl ghm Z]oblZ[e^) R^ \hglb]^k ma^l^ ]b__^k^g\^l [hma ik^ebfbgZkr Zg] jnZebmZmbo^ Zm mabl lmZ`^) Dg \hgmkZlm mh ?Y[ leh(,),' ebmme^ oZkbZmbhg bg mkZgl\kbimbhg h_ ?Y[ leh(,)- \aZgg^e oZkbZgml pZl h[l^ko^] Zfhg` ]^o^ehif^gmZe lmZ`^l hk Z]nem mblln^l*`^g]^kl' pbma ?Y[ leh(,)-)1 #ma^ _nee e^g`ma mkZgl\kbim$ [^bg` ma^ fZchk blh_hkf #Ab`) 1(/> Zg] ?$) >hfiZkblhg h_ lieb\^ oZkbZgml bg iZkZlbmb\ g^fZmh]^l pbma ma^ ,0 lieb\^ oZkbZgml ]^l\kb[^] _hk 1# KRKMGTY k^o^Zel _bo^ fZbg k^`bhgl pa^k^ ]b__^k^gmbZe lieb\bg` h\\nkl #Ab`) 1(-$) Oa^ _bklm lbm^ bl Zg Zem^kgZmbo^ ^qhg # O#K#! ik^l^gm hk ghm$' ma^ Z[l^g\^ h_ pab\a k^lneml bg ma^ nl^ h_ Z ]hpglmk^Zf

,40 1NGVZKX +

\hgl^ko^] makhn`ahnm ma^ ^ohenmbhg h_ NGJ(, \aZgg^el bg g^fZmh]^l Zg] mph o^klbhgl Zk^ ik^l^gm bg ?# S[XOY Zg] ?# Y[OY NGJ(,),) Dg Zee l^o^g l^jn^g\^l \ehg^] _khf Zl\Zkb]l Zg] _beZkbZ^' ma^ \hkk^lihg]bg` k^`bhg lahpl ab`a^k lbfbeZkbmr mh 1# KRKMGTY NGJ(,Z) Chp^o^k' Zem^kgZmbo^ l^jn^g\^l p^k^ b]^gmb_b^] bg ma^ `^ghf^l h_ /# Y[[S ' ;# \UR\[R[Y Zg] 0# SGRG_O #0SG NGJ(,a bg Ab`) 1(- Zg] Nniie^f^gmZkr OZ[) 1(.$)

8;"& INGTTKRY < fZqbfnf(ebd^ebahh] ZiikhZ\a pZl nl^] mh \Ze\neZm^ Z iareh`^g^mb\ mk^^ _khf ma^ NGJ(, Zfbgh Z\b] l^jn^g\^l #Ab`) 1(0<$) # XGZZO bl [ZlZe mh Z `khni \hgmZbgbg` Zee \eZ]^ DDD Zg] \eZ]^ Q l^jn^g\^l' [nm ma^ lniihkm oZen^l _hk mabl ihlbmbhg Zk^ kZma^k ehp bg [hma o^klbhgl h_ ma^ ZiikhqbfZm^ ebd^ebahh] m^lm #Ab`) 1(0<$) Oa^ Z]]bmbhgZe iZkZeh` NGJ(,)- ik^l^gm bg \eZ]^ D iZkZlbmb\ g^fZmh]^l bl ieZ\^] Zl Z lblm^k hi^kZmbhgZe mZqhghfb\ ngbm #JOP$ mh ma^ NGJ( ,), iZkZeh` bg mabl \eZ]^) Oabl ln``^lml maZm ]nieb\Zmbhg h_ ma^ YRU"& `^g^ h\\nkk^] Z_m^k ma^ mkb\ah\^iaZeb]l ]bo^k`^] _khf ma^ hma^k `khnil Zg] bl ghm Zg Zg\^lmkZe _^Zmnk^ h_ g^fZmh]^ `^ghf^l) Oh ikho^ maZm ]b__^k^gmbZe lieb\^ oZkbZgml p^k^ \hgl^ko^] makhn`ahnm g^fZmh]^ ^ohenmbhg Zm ma^ 1# KRKMGTY Zem^kgZmbo^ lieb\^ lbm^ _hnk' hger ma^ Zfbgh Z\b] l^jn^g\^l h_ mabl ^qhg p^k^ Zeb`g^] Zg] ln[c^\m^] mh iareh`^g^mb\ ZgZerlbl) Ahk mabl inkihl^' Zem^kgZmbo^ ^qhgl b]^gmb_b^] bg ma^ `^ghf^l h_ /# Y[[S Zg] ;# \UR\[R[Y p^k^ bg\en]^]) Oa^ iZkmbZe ]nieb\Zmbhg h_ mabl ^qhg bg 0SG NGJ(,\*] pZl Zelh bg\en]^] Zl Z l^iZkZm^ JOP # 0SG NGJ(,\ #iZkm) ]nie)$ bg Ab`) 1(-$) M^lneml Zk^ ]^ib\m^] bg Ab`) 1(0=) ?n^ mh ma^ lfZee lbs^ h_ ma^ l^jn^g\^' lmZmblmb\Ze lniihkm _hk

,41 3SUJKVYOJK GTJ >8;"& bg]bob]nZe gh]^l bl ehp^k maZg _hk _nee(e^g`ma l^jn^g\^l) Chp^o^k' ma^k^ bl \e^Zker Z g^fZmh]^(li^\b_b\ `khni pbma ab`a lbfbeZkbmr mh ma^ l^jn^g\^ bg 1# KRKMGTY NGJ(,Z' Zemahn`a ma^ ^qhg l^jn^g\^l bg ma^ mkb\ah\^iaZeb] li^\b^l lmkhg`er ]bo^k`^ _khf mahl^ bg \eZ]^ DDD Zg] Q g^fZmh]^l) Oa^ l^\hg] `khni \hgmZbgl ^qhg l^jn^g\^l _khf [hma g^fZmh]^l Zg] Zkmakhih]l' bg\en]bg` [hma Zem^kgZmbo^ ^qhgl ^g\h]^] bg ma^ 2# SKRGTUMGYZKX `^ghf^) ?bo^klbmr pbmabg mabl `khni bl fn\a ab`a^k Zg] ]^^i ]bo^k`^g\^ iZmm^kgl \hne] ghm [^ k^lheo^]) Oa^k^_hk^' ma^ `khni \hglblml h_ mak^^ fZchk ebg^Z`^l' O#K# #b$ ?XOIN[XOY NGJ(,),[( ebd^ Zg] Zkmakhih] l^jn^g\^l pab\a fb`am ma^k^_hk^ [^ \hglb]^k^] mh [^ ÜZg\^lmkZeá' #bb$ ma^ ^qhg ^g\h]^] bg YRU (&#' `^g^l' #bbb$ ma^ l^jn^g\^l ]^kbo^] _khf \eZ]^ DDD Zg] Q g^fZmh]^l)

,42 1NGVZKX +

9WU& .%-& Kareh`^g^mb\ ZgZerlbl h_ g^fZmh]^ NGJ(, \aZgg^el <$ Kareh`kZf h[mZbg^] [r fZqbfnf ebd^ebahh] ZgZerlbl _khf _nee(e^g`ma NGJ(, \aZgg^el) NGJ(, ikhm^bg l^jn^g\^l _khf ma^ g^fZmh]^ li^\b^l 1# KRKMGTY # 1KR $' 1# HXOMYYGK # 1HX$' 1# XKSGTKO # 1XK $' <# VGIOLOI[Y # # XGZZO # >XG $' ?# S[XOY # ?S[ $ Zg] ?# Y[OY # ?Y[ $ p^k^ Zeb`g^] mh`^ma^k pbma hkmaheh`l _khf 2# SKRGTUMGYZKX # 2SK $' /TUVNKRKY MGSHOGK # /MG $' enlmZeS-) ,43 3SUJKVYOJK GTJ >8;"&

Ahk 0# SGRG_O hger ma^ ^qi^kbf^gmZeer b]^gmb_b^] lieb\^ oZkbZgm NGJ(,_ Zg] _hk 1# KRKMGTY hger ma^ oZkbZgml NGJ(,Z(\ p^k^ bg\en]^]) Oa^ EOO fh]^e h_ Zfbgh Z\b] ln[lmbmnmbhgl pZl nl^] Zg] KarHG pZl l^m mh himbfbl^ ma^ gnf[^k h_ bgoZkbZ[e^ lbm^l pabe^ Zfbgh Z\b] _k^jn^g\b^l p^k^ [Zl^] hg ma^ fh]^e) Oa^ gnf[^k h_ " ]blmkb[nm^] ln[lmbmnmbhg kZm^ \Zm^`hkb^l pZl l^m mh ,1 Zg] KarHG himbfbl^] ma^ " laZi^ iZkZf^m^k) Nniihkm _hk bg]bob]nZe gh]^l pZl \Ze\neZm^] nlbg` ma^ Nabfh]ZbkZ(CZl^`ZpZ fh]b_b\Zmbhg Zg] Z [ZrlbZg mkZgl_hkfZmbhg h_ ma^ ZiikhqbfZm^ ebd^ebahh] kZmbh m^lm Zg] k^lneml Zk^ lahpg \ehl^ mh ma^ gh]^l [^_hk^ Zg] Z_m^k ma^ leZla' k^li^\mbo^er) Ahk mahl^ \Zl^l p^k^ lniihkm oZen^l p^k^ ghm lahpg g^qm mh ma^ gh]^ ma^r Zk^ lahpg hg ma^ kb`am Zg] k^_^k mh ma^ fhlm m^kfbgZe gh]^ hg ma^ lZf^ o^kmb\Ze ihlbmbhg) Oa^ l\Ze^ [Zk k^ik^l^gml +)- ln[lmbmnmbhgl i^k lbm^) >' >knlmZ\^Z6 B' BZlmkhih]Z6 Q^km' Q^km^[kZmZ6

AURZGMK IRGSV K^VKXOSKTZY QhemZ`^(]^i^g]^gm \nkk^gml p^k^ f^Zlnk^] bg pZm^k(bgc^\m^] hh\rm^l #Ab`) 1(1<$) l' bg]b\Zmbg` maZm ma^ hh\rm^l p^k^ bg `hh] iarlbheh`b\Ze \hg]bmbhg #]ZmZ ghm lahpg$) >nkk^gml ]^m^\m^] bg pZm^k(bgc^\m^] hh\rm^l p^k^ ghm lb`gb_b\Zgmer bg_en^g\^] [r ma^ o^ab\e^ #+), ?HNJ* +)++. Kenkhgb\ A(13$ hk [r ,+ H ^fh]^ilb]^ #Ab`) 1(1<$) Dg ma^ Z[l^g\^ h_ ^fh]^ilb]^' [ZlZe DQ>l [^mp^^g pZm^k Zg] >^eNGJ(,Z bgc^\m^] hh\rm^l p^k^ o^kr lbfbeZk) Chp^o^k' ma^k^ pZl Z lfZee [nm lb`gb_b\Zgm ab`a^k \nkk^gm Zm &-+ fQ bg 1KR NGJ(,Z bgc^\m^] hh\rm^l' pab\a \hkk^lihg]l mh ma^ ohemZ`^ h_ ZiikhqbfZm^er + fQ mh &-+ fQ g^^]^] mh hi^g 1KR NGJ(,Z Zm Z ehp \Ze\bnf \hg\^gmkZmbhg h_ ,+ H V04W) Oabl ]b__^k^g\^ pZl Zelh h[l^ko^] bg ma^ ik^l^g\^ h_ ma^ o^ab\e^ Zg] ma^k^ pZl gh lb`gb_b\Zgm ]b__^k^g\^ [^mp^^g [ZlZe DQ>l Zg] DQ>l bg ma^ ik^l^g\^ h_ ma^ o^ab\e^ #Ab`) 1(2=$) Dgm^k^lmbg`er' \nkk^gml ]b] ghm bg\k^Zl^ _nkma^k pa^g ahe]bg` ihmbhg Z[ho^ &-+ fQ p^k^ Ziieb^] #Ab`) 1(1=$ Zg] gh ]b__^k^g\^l mh pZm^k bgc^\m^] hh\rm^l p^k^ h[l^ko^] Zm &/+ fQ Zg] &1+ fQ #Ab`) 1(2=$) Ih bg\k^Zl^ bg \nkk^gml Zm &-+ fQ pZl ]^m^\m^] bg hh\rm^l bgc^\m^] pbma ?S[ NGJ(,Z \MI< #Nniie^f^gmZkr Ab`) 1( 3$) Dg _Z\m' \nkk^gml f^Zlnk^] bg ?S[ NGJ(,Z(bgc^\m^] hh\rm^l p^k^ lb`gb_b\Zgmer ehp^k maZg bg pZm^k(bgc^\m^] hh\rm^l Zm + fQ Zg] &-+ fQ ahe]bg` ihm^gmbZe) l ]^obZm^] _khf ebg^Zkbmr' ln``^lmbg` Z ghgiarlbheh`b\Ze k^lihgl^ h_ ma^ hh\rm^l) Dg Zg Zmm^fim mh bg\k^Zl^ ma^ ]b__^k^g\^ _hk 1KR NGJ(,Z hk ?S[ NGJ( ,Z' hh\rm^l p^k^ ik^bg\n[Zm^] bg - `*fe h_ ma^ \Ze\bnf bhghiahk^ <-.,32 #Nb`fZ

9WU& .%.& >nkk^gml h[l^ko^] bg ohemZ`^(\eZfi ^qi^kbf^gml M^ik^l^gmZmbo^ \nkk^gml ]^m^kfbg^] bg hh\rm^l bgc^\m^] pbma <$ pZm^k' =$ 1KR leh(,Z \MI< bg ma^ Z[l^g\^ h_ ^fh]^ilb]^ Zg] >$ 1KR leh(,Z \MI< bg ma^ ik^l^g\^ h_ ,+ H ^fh]^ilb]^)

-++ 3SUJKVYOJK GTJ >8;"&

9WU& .%/& ?^m^kfbgZmbhg h_ ^fh]^ilb]^ ^__^\ml hg \nkk^gm ohemZ`^ \nko^l bg C# RGK\OY hh\rm^l bgc^\m^] pbma 1KR NGJ(,Z \MI<

<$ DQ>l #f^Zgl É N@H$ p^k^ k^\hk]^] bg pZm^k bgc^\m^] hh\rm^l pbmahnm Z]]bmbhg h_ ]kn`l #[ZlZe$' Z_m^k Z]]bmbhg h_ ma^ o^ab\e^ #+), ?HNJ' +)++. Kenkhgb\ A(13$ Zg] Z_m^k Z]]bmbhg h_ ,+ H ^fh]^ilb]^ #^fh$ #g8,+$) =$ >nkk^gml h[mZbg^] _khf hh\rm^l bgc^\m^] pbma pZm^k #g8,+$ hk 1KR leh(,Z \MI< bg ma^ Z[l^g\^ h_ Zgr ]kn` #[ZlZe' g83$ hk bg ma^ ik^l^g\^ h_ o^ab\e^ #+), ?HNJ' +)++. Kenkhgb\ A(13$ #g83$) Oa^ Zlm^kbld ab`aeb`aml Z lb`gb_b\Zgm ]b__^k^g\^ h_ [hma \nko^l h[mZbg^] _khf 1KR leh(,Z \MI< bgc^\m^] `khnil h_ hh\rm^l mh ma^ pZm^k bgc^\m^] hh\rm^l) >$ >nkk^gml p^k^ k^\hk]^] bg 1KR leh(,Z bgc^\m^] hh\rm^l bg ma^ ik^l^g\^ h_ o^ab\e^ #+), ?HNJ' +)++. Kenkhgb\ A(13$' hk ^fh]^ilb]^ #, H hk ,+ H -+, 1NGVZKX +

^fh$ #g8,+$) Ahk ,+ H ^fh]^ilb]^ ma^ nii^k Zlm^kbldl lrf[hebl^ ma^ \hfiZkblhg mh , H ^fh]^ilb]^ Zg] ma^ ehp^k ma^ \hfiZkblhg mh ma^ o^ab\e^ \hgmkhe) Oa^ Zlm^kbldl Zm ma^ , H ^fh]^ilb]^ \nko^ bg]b\Zm^ lb`gb_b\Zgm ]b__^k^g\^l mh ma^ \hgmkhe) ?$ Jh\rm^l bgc^\m^] pbma 1KR leh(,Z p^k^ bg\n[Zm^] pbma , H #g81$ hk ,+ H #g82$ ^fh]^ilb]^ #^fh$ [^_hk^ k^\hk]bg` ma^ DQ> \nko^l) Oa^g hh\rm^l p^k^ i^k_nl^] pbma ghkfZe _kh` kbg`^k _hk 0 hk ,+ fbg' k^li^\mbo^er' [^_hk^ Z l^\hg] DQ> pZl k^\hk]^] _khf ma^ lZf^ hh\rm^l) @$ Jh\rm^l p^k^ ik^bg\n[Zm^] bg ma^ Z[l^g\^ h_ ]kn`l #[ZlZe$ hk pbma , H o^kkn\neh`^g #o^kkn\$ [^_hk^ DQ>l p^k^ k^\hk]^]) Oa^g' hh\rm^l p^k^ i^k_nl^] _hk - fbg [^_hk^ , H ^fh]^ilb]^ #^fh$ pZl Z]]^] #g83$) A$ Jh\rm^l bgc^\m^] pbma pZm^k #g8,+$ hk pbma 1KR leh(, \MI< #g81$ p^k^ bg\n[Zm^] pbma , H ^fh]^ilb]^ #^fh$ [^_hk^ DQ>l p^k^ k^\hk]^]) <_m^k i^k_nlbhg pbma ghkfZe _kh` kbg`^k _hk - fbg' o^kkn\neh`^g #o^kkn\$ pZl Z]]^] _hk - fbg _heehp^] [r k^\hk]bg` h_ DQ>l)%' <7+)+06 %%' <7+)++,6 %%%' <7+)+++,)

-& Dg ma^ Z[l^g\^ h_ Z lmbfnenl bg\k^Zlbg` V>Z Wb' Z]]bmbhg h_ ^fh]^ilb]^ mh 1KR leh(,Z(bgc^\m^] hh\rm^l k^lnem^] bg ]kZfZmb\Zeer bg\k^Zl^] \nkk^gml #Ab`) 1(1>$ pbma lb`gb_b\Zgmer lmkhg`^k ^__^\ml Zm ,+ H maZg , H ^fh]^ilb]^ #Ab`) 1(2>$) ?b__^k^g\^l p^k^ lb`gb_b\Zgm Zm Zee ahe]bg` ihm^gmbZel ^q\^im _hk &1+ fQ Zm [hma ^fh]^ilb]^ \hg\^gmkZmbhgl) DQ>l h[mZbg^] bg ma^ ik^l^g\^ h_ ^fh]^ilb]^ Zk^ \aZkZ\m^kbl^] [r mph o^kr k^fZkdZ[e^ _^Zmnk^l) Abklmer' \nkk^gml bg\k^Zl^] ^o^g Zm ahe]bg` ihm^gmbZel _Zk [^ehp ma^ ^qi^\m^] hi^gbg` ihm^gmbZe h_ NGJ(, \aZgg^el' ln``^lmbg` maZm \aZgg^e hi^gbg` \Zg h\\nk bg]^i^g]^gmer h_ f^f[kZg^ ihm^gmbZe) N^\hg]er' \nkk^gml i^Zd^] Zm + fQ Zg] lb`gb_b\Zgmer ]^\k^Zl^] Zm ab`a^k ahe]bg` ihm^gmbZel' k^lnembg` bg [^ee laZi^] DQ>l #Ab`) 1(2>$) l) @o^g i^k_nlbhg _hk -0 fbg ]b] ghm k^]n\^ ma^ ^fh]^ilb]^ ^__^\ml #g8.' ]ZmZ ghm lahpg$) @__^\ml h_ ma^ NGJ(, li^\b_b\ [eh\d^k o^kkn\neh`^g k^o^Ze^] maZm ma^ hk]^k h_ Z]]bmbhg lmkhg`er bg_en^g\^] ma^ hnm\hf^) Kk^bg\n[Zmbhg h_ hh\rm^l pbma o^kkn\neh`^g Zehg^ aZ] gh ^__^\ml hg DQ>l6 ^o^g ma^ leb`am bg\k^Zl^ bg \nkk^gml Zm &-+ fQ h[l^ko^] bg 1KR leh(,Z( bgc^\m^] hh\rm^l pZl ghm [eh\d^] #\hfiZk^ Ab`) 1(2= Zg] 1(2@$) Chp^o^k' Z]]bmbhg h_ o^kkn\neh`^g [^_hk^ ^fh]^ilb]^ \hfie^m^er ik^o^gm^] ^fh]^ilb]^ ^__^\ml hg DQ>l #Ab`) 1( 2@$) Dg \hgmkZlm' pa^g o^kkn\neh`^g pZl Z]]^] mh hh\rm^l bg ma^ ik^l^g\^ h_ ^fh]^ilb]^' gh ]^\k^Zl^ bg ^fh]^ilb]^(bg]n\^] \nkk^gml pZl ]^m^\m^] #Ab`) 1(2A$)

-+- 3SUJKVYOJK GTJ >8;"&

.&- 7WaQcaaW]\

Oa^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l aZl ehg` [^^g Z fZmm^k h_ ]^[Zm^' pbma bhghmkhib\ B<=< < k^\^imhkl V.4'1+W' ma^ eZmkhiabebg k^\^imhk GZ Wb e^o^el) Oa^l^ gho^e _bg]bg`l \hg_bkf maZm NGJ(, bl Z ]bk^\m mZk`^m h_ ^fh]^ilb]^) Oa^ \r\ehh\mZ]^ilbi^imb]^l' ^q^fieb_b^] [r ^fh]^ilb]^' k^ik^l^gm Zg bfihkmZgm g^p \eZll h_ Zgma^efbgmb\l \aZkZ\m^kbl^] [r ma^bk k^lblmZg\^([k^Zdbg` ikhi^kmb^l V1.W) >r\ehh\mZ]^ilb( i^imb]^l aZo^ Z o^kr [khZ] g^fZmb\b]Ze Z\mbobmr bg Z pb]^ kZg`^ h_ ahlm li^\b^l V1/W) C^k^ bm aZl \e^Zker [^^g ]^fhglmkZm^] maZm NGJ(, bl ^g\h]^] bg ma^ `^ghf^l h_ iZkZlbmb\ g^fZmh]^l bg Zee fZchk iareh`^g^mb\ `khnil #\eZ]^ D Zg] \eZ]^l DDD(Q$) Oabl bl bg k^fZkdZ[e^ \hgmkZlm mh ma^ mZk`^m h_ Zghma^k g^p \eZll h_ Zgma^efbgmb\l' ma^ Zfbgh Z\^mhgbmkbe^ ]^kboZmbo^l ln\a Zl fhg^iZgm^e' _hk pab\a gh k^\^imhk aZl [^^g _hng] bg ># XGZZO V-2W Zg] 2# OSSOZOY V10W) ?^libm^ ma^l^ _bg]bg`l' fb\kh_beZkb\b]Ze ^__b\Z\r h_ fhg^iZgm^e pZl ]^m^\m^] #Ze[^bm Zm ab`a \hg\^gmkZmbhgl$ V10W' pa^k^Zl bm pZl bgZ\mbo^ Z`Zbglm ># XGZZO V..W) Oa^ hma^k g^p Zgma^efbgmb\' ]^kjnZgm^e' pZl _hng] mh [^ hger Z fb](li^\mknf Zgma^efbgmb\ bg ma^ ]hl^ kZg`^ m^lm^] #+)0 Ö 3 f`*d` [h]rp^b`am$' lahpbg` _nee ^__b\Z\r #940 $ Z`Zbglm G/ Zg] Z]neml h_ ?XOINUYZXUTM_R[Y lii) Zg] :KSGZUJOX[Y lii) Zl p^ee Zl Z`Zbglm Z]neml h_ 6# IUTZUXZ[Y ) Chp^o^k' ^__b\Z\r pZl ln[himbfZe Z`Zbglm G/ Zg] Z]neml h_ ?# IOXI[SIOTIZG ' G/ h_ 6# IUTZUXZ[Y ' Zg] lhf^ eZk`^ bgm^lmbgZe g^fZmh]^l V11W)

-+. 1NGVZKX + h_ ma^ hma^k \nkk^gm ]kn` \Zg]b]Zm^l Zl beenlmkZm^] [r ma^ ^__b\Z\r Z`Zbglm ma^ aZk] mh mk^Zm g^fZmh]^l h_ ma^ `^gnl ?XOIN[XOY ) Ih ]kn` bl ZoZbeZ[e^ pab\a k^ebZ[er \nk^l anfZg ?# ZXOINO[XG bg_^\mbhgl nlbg` Z lbg`e^ ]hl^' [nm ^fh]^ilb]^ aZl [^^g lahpg mh aZo^ ^q\^ee^gm Z\mbobmr Z`Zbglm ?# \[RVOY V2.'2/W Zg] ?# S[XOY V20'21W) Oa^ C# RGK\OY ^qik^llbhg lrlm^f aZl [^^g pb]^er nl^] mh \aZkZ\m^kbl^ ma^ _ng\mbhg h_ g^fZmh]^ bhg \aZgg^el Zg] bg iZkmb\neZk k^\^imhkl _hk g^nkhmkZglfbmm^kl V22(24W) Dm aZl l^o^kZe Z]oZgmZ`^l bg\en]bg` kh[nlmg^ll' lbfnemZg^hnl ^qik^llbhg h_ ikhm^bgl # K#M# ' ZnqbebZkr ikhm^bgl hk fnembie^ ln[ngbml$ V23W' Zg] eZk`^ \^eel pab\a Zeehp ^Zlr Ziieb\Zmbhg h_ ma^ mph ^e^\mkh]^ ohemZ`^ \eZfi m^\agbjn^ V3+W) Chp^o^k' ma^k^ bl Zelh Z ]kZp[Z\d h_ nlbg` hh\rm^l pa^g phkdbg` pbma \Ze\bnf k^lihglbo^ \aZgg^el ln\a Zl NGJ(,) Oa^ \^ee bl lh eZk`^ maZm bm bl ghm ihllb[e^ mh [n__^k ma^ \rmhieZlf mh Z ]^_bg^] \Ze\bnf \hg\^gmkZmbhg) Dglb]^ hnm iZm\a \eZfi k^\hk]bg` phne] [^ k^jnbk^] mh i^k_hkf mabl mri^ h_ ^qi^kbf^gm V04W) Oa^k^_hk^' Z\mboZmbhg h_ -& ma^ NGJ(, \aZgg^e [r lbfnemZg^hnler bg\k^Zlbg` V>Z Wb Zg] ]^iheZkblZmbhg h_ ma^ \^eel pZl -& ghm ihllb[e^ bg mabl \hg_b`nkZmbhg) Z Wb [r ik^bg\n[Zmbhg h_ hh\rm^l pbma ma^ \Ze\bnf bhghiahk^ <-.,32 p^k^ ghm ln\\^ll_ne Zg] k^lnem^] bg \^eel ehhdbg` o^kr nga^Zemar Zg] ^qab[bmbg` eZk`^ e^Zd \nkk^gml #ghm lahpg$) <\mbobmr h_ ma^ 1KR NGJ(,Z \aZgg^e pZl hger h[l^ko^] bg ma^ ik^l^g\^ h_ ^fh]^ilb]^' Zg] \nkk^gml f^]bZm^] [r ?S[ NGJ(,),Z \hne] ghm [^ h[l^ko^] Zm Zee) Dg ma^ Z[l^g\^ h_ Zgr hma^k Z`hgblm h_ g^fZmh]^ NGJ(, \aZgg^el Zg] pbmahnm ma^ Z[bebmr mh ikho^ _ng\mbhgZe ^qik^llbhg h_ -& ?S[ NGJ(,),Z [r ]^m^kfbgbg` \nkk^gml ^ohd^] [r bg\k^Zl^] V>Z Wb Zg] ]^iheZkblZmbhg' ma^ _Zbenk^ mh ]^m^\m ^fh]^ilb]^ ^__^\ml \Zgghm [^ bgm^kik^m^] Zl ^fh]^ilb]^ ngk^lihglbo^g^ll) Dg _Z\m' \nkk^gml bg ?S[ NGJ(,),Z(bgc^\m^] hh\rm^l p^k^ ehp^k maZg mahl^ h[l^ko^] bg pZm^k( bgc^\m^] hh\rm^l' ln``^lmbg` maZm lhf^ ghgiarlbheh`b\Ze \aZg`^l aZo^ h\\nkk^] bg ma^ \^eel) Oabl bl lniihkm^] [r ma^ _Z\m maZm ma^ DQ>l bg ma^ Z[l^g\^ h_ ^fh]^ilb]^ lb`gb_b\Zgmer ]^obZm^] _khf ebg^Zkbmr Zm ab`a ohemZ`^l' ngebd^ \nkk^gml h[l^ko^] bg pZm^k(bgc^\m^] hh\rm^l) Nbg\^ ?# S[XOY bl _neer lnl\^imb[e^ mh ^fh]^ilb]^ V.,'20'21W' bm bl ngebd^er maZm NGJ(, _khf mabl iZkZlbm^ lahne] ghm k^lihg] mh mabl ]kn`) Chp^o^k' ]n^ mh ma^ ik^l^g\^ h_ mph YRU"& iZkZeh`l bg ma^ ?# S[XOY `^ghf^' bm \Zgghm [^ kne^] hnm maZm hger ?S[ NGJ(,)- bl ^fh]^ilb]^ k^lihglbo^)

-+/ 3SUJKVYOJK GTJ >8;"&

Dg ma^ Z[l^g\^ h_ ^fh]^ilb]^' gh eZk`^ \nkk^gml p^k^ h[l^ko^] _hk 1KR NGJ(,Z' pab\a bl -& ^qi^\m^] lbg\^ V>Z Wb pZl ghm bg\k^Zl^]) Chp^o^k' ma^k^ pZl Z leb`am [nm lb`gb_b\Zgm Zg] ab`aer k^ikh]n\b[e^ bg\k^Zl^ bg \nkk^gm Zm &-+ fQ ahe]bg` ihm^gmbZe' pab\a \hkk^lihg]l mh ma^ hi^gbg` ihm^gmbZe k^ihkm^] _hk 1# KRKMGTY NGJ(, Zm ehp \Ze\bnf \hg\^gmkZmbhgl V04W) Oabl lfZee \nkk^gm fZr k^ik^l^gm Z fbghk Z\mboZmbhg h_ Z _^p \aZgg^el ^o^g bg ma^ Z[l^g\^ h_ \Ze\bnf lb`gZeebg`) Chp^o^k' bm k^fZbgl ng\e^Zk par mabl pZl ghm h[l^ko^] Zm fhk^ ihlbmbo^ ahe]bg` ihm^gmbZel) Hhk^ho^k' bg\k^Zl^] \nkk^gml Zm &-+ fQ p^k^ Zelh h[l^ko^] bg ma^ ik^l^g\^ h_ ma^ NGJ(, \aZgg^e [eh\d^k o^kkn\neh`^g k^`Zk]e^ll b_ Z]]bmbhg h_ o^kkn\neh`^g pZl _heehp^] [r ^qihlnk^ mh ^fh]^ilb]^) Kk^bg\n[Zmbhg pbma o^kkn\neh`^g \hfie^m^er Z[hebla^] ma^ ^__^\ml h_ ^fh]^ilb]^ Zg] Z`Zbg hger ma^ lfZee Z]]bmbhgZe \nkk^gm Zm &-+ fQ pZl ]^m^\m^]) Dg \hgmkZlm' o^kkn\neh`^g aZ] gh lb`gb_b\Zgm ^__^\m pa^g ^fh]^ilb]^ pZl Ziieb^] _bklm) Oabl ln``^lml maZm [hma ]kn`l [bg] o^kr mb`amer mh 1KR NGJ(,Z Zg] \Zgghm ]blieZ\^ ^Z\a hma^k hg\^ ma^r aZo^ [hng]) Cb`a(Z__bgbmr [bg]bg` h_ ^fh]^ilb]^ mh bml mZk`^m bl Zelh ln``^lm^] [r ma^ _Z\m maZm ikhehg`^] i^k_nlbhg h_ ma^ hh\rm^l Z_m^k k^fhoZe h_ ^fh]^ilb]^ ]b] ghm k^o^kl^ \aZgg^e hi^gbg`) Q^kr lbfbeZk h[l^koZmbhgl aZo^ [^^g k^ihkm^] _hk ^__^\ml h_ ^fh]^ilb]^ hg /# Y[[S fnl\e^ _eZil V1-W) Oh`^ma^k pbma ma^ lehp hgl^m h_ ^fh]^ilb]^ ^__^\ml V1-W' ma^ _Z\m maZm ma^ ]kn` ^__^\ml p^k^ ghm k^o^klb[e^ fb`am ln``^lm maZm ^fh]^ilb]^ ]h^l ghm [bg] mh ma^ ^qmkZ\^eeneZk ]hfZbg h_ NGJ(,' [nm bglm^Z] [bg]l mh Zg bgmkZ\^eeneZk ]hfZbg hk mh ma^ mkZglf^f[kZg^ a^eb\^l) Oa^ eZmm^k ihllb[bebmr bl bg Z`k^^f^gm pbma bml ab`aer ebihiabeb\ gZmnk^) Chp^o^k' lbg\^ ^fh]^ilb]^ g^^]l ^o^g ehg`^k mbf^l mh Z\mboZm^ ma^ B ikhm^bg \hnie^] k^\^imhk G

KA,+--< pZl lahpg mh [bg] mh ma^ ^qmkZ\^eeneZk IC - m^kfbgZe iZkm h_ GZ Wb \Zg [^ ^qi^\m^] mh [^ _Zbker ehp lbg\^ ma^k^ pZl gh

-+0 1NGVZKX + bg\k^Zl^] \nkk^gm bg ma^ Z[l^g\^ h_ 1# KRKMGTY NGJ(,' ma^ \hg\^gmkZmbhg h_ fZ`g^lbnf bg C# RGK\OY hh\rm^l aZl [^^g k^ihkm^] mh [^ ZiikhqbfZm^er +)2 fH V3.W) Ra^ma^k mabl bl Zelh ma^ \Zl^ bg ma^ ik^l^gm lmn]r \hne] ghm [^ k^lheo^] nlbg` ma^ \nkk^gm ohemZ`^(\eZfi l^m ni' [nm k^jnbk^l iZm\a(\eZfi lmn]b^l bg pab\a ma^ \hg\^gmkZmbhg h_ ma^l^ \Zmbhgl \Zg [^ mb`amer \hgmkhee^]) Dg]^^]' ]^\k^Zl^] \nkk^gml Zm ab`a ahe]bg` ihm^gmbZel bg k^lihgl^ mh ^fh]^ilb]^ aZo^ ghm [^^g h[l^ko^] _hk ^qik^llbhg h_ 1# KRKMGTY NGJ(, bg C@F-4. \^eel V3/W) ?^libm^ ma^bk o^kr lbfbeZk fhkiaheh`r' `^g^mb\ ]bo^klbmr h_ g^fZmh]^l bl dghpg mh [^ an`^ V30W) Z Wb Zg] ]^m^kfbg^ bml ^__^\m hg \aZgg^e k^lihgl^l) Oa^ oZkbhnl YRU"& lieb\^ oZkbZgml b]^gmb_b^] bg iZkZlbmb\ g^fZmh]^l a^k^ lahp maZm ^ohenmbhg aZl h\\nkk^] Zm ab`aer \hgl^ko^] Zem^kgZmbo^ lieb\^ lbm^l #lieb\^ k^`bhg / pbma Zem^kgZmbo^ ^qhgl ik^l^gm bg g^fZmh]^l' Zkmakhih]l Zg] o^km^[kZm^l Zm ma^ lZf^ ihlbmbhg$ Zl Zehg` pbma ^ohenmbhg h_ g^fZmh]^ hk \eZ]^(li^\b_b\ lieb\^ oZkbZgml) Ang\mbhgZe ZgZerlbl \Zg Z]]k^ll ma^ ^__^\ml h_ Zem^kgZmbo^ lieb\bg` hg ma^ ikh[Z[bebmr h_ ihlmmkZgleZmbhgZe fh]b_b\Zmbhgl' \aZgg^e ^e^\mkh\a^fb\Ze Zg] iaZkfZ\heh`b\Ze ikhi^kmb^l Zg] ihllb[e^ a^m^khf^kblZmbhg [^mp^^g ln[ngbml ^g\h]^] [r ]b__^k^gm lieb\^ oZkbZgml hk ^o^g iZkZeh`l) Ahk bglmZg\^' ma^ Zem^kgZmbo^ ^qhg bg lieb\^ k^`bhg / bl eh\Zm^] bff^]bZm^er [^abg] mph ab`aer \hgl^ko^] iahliahkreZmbhg lbm^l' Zg] bm bl ebd^er maZm l^jn^g\^ oZkbZmbhg bg ma^ g^b`a[hnkahh] h_ ma^l^ lbm^l Zelh Z__^\ml ma^ iahliahkreZmbhg iZmm^kg Zg] _k^jn^g\r) OaZm 0# SGRG_O Zg] 0# VGNGTMO Zk^ kZma^k ngk^lihglbo^ mh ^fh]^ilb]^ OT \O\U Zg] OT \OZXU V2+( 2-W' \Zgghm [^ ^Zlber ^qieZbg^] [r ma^ ikbfZkr lmkn\mnk^ h_ 0SG NGJ(,' pab\a bl obkmnZeer b]^gmb\Ze mh maZm h_ hma^k _beZkbZ^) Ra^ma^k mabl ]b__^k^g\^ bg lnl\^imb[bebmr bl ]n^ mh mZk`^m lbm^ k^eZm^] ]b__^k^g\^l # K#M#! ]b__^k^gm lieb\^ oZkbZgml hk \hf[bgZmbhg h_ ln[ngbml$ hk ]n^ mh hma^k #ghm NGJ(, k^eZm^]$ f^\aZgblfl ikhm^\mbg` 0X[MOG _khf ^fh]^ilb]^ ^__^\ml \hne] [^ Zglp^k^] [r \hfiZkbg` ^e^\mkhiarlbheh`b\Ze ikhi^kmb^l h_ ]b__^k^gm lieb\^ oZkbZgml [^mp^^g _beZkbZe li^\b^l) Hhk^ho^k' ma^ ab`a gnf[^k h_ lieb\^ oZkbZgml ^g\h]bg` l^o^k^er mkng\Zm^] NGJ(, ikhm^bgl bg [hma ?XOIN[XOY li^\b^l lahne] [^ _nkma^k ZgZerl^]) Jg ma^ hg^ aZg]' mkng\Zm^] o^klbhgl h_ NGJ(, pbma lmhi \h]hgl [^mp^^g ma^ N/ f^f[kZg^ a^ebq Zg] ma^ ^g] h_ ma^ _bklm M>F ]hfZbg

-+1 3SUJKVYOJK GTJ >8;"&

#k^`neZmhk h_ \hg]n\mbhg h_ ihmZllbnf$ aZo^ [^^g lahpg mh [^ ab`aer k^lblmZgm mh ^fh]^ilb]^

V-,W) Jg ma^ hma^k aZg]' Z mkng\Zm^] o^klbhg \hgmZbgbg` hger ma^ IC - m^kfbgZe iZkm h_ Z fhnl^ NGJ(, hkmaheh` _khf ma^ lmZkm \h]hg mh ma^ N1 mkZglf^f[kZg^ k^`bhg _hkfl Z _ng\mbhgZe \aZgg^e V31W) Oa^k^_hk^' Z _ng\mbhgZe khe^ h_ lhf^ h_ ma^ mkng\Zm^] o^klbhgl \Zgghm [^ ^q\en]^]' ^li^\bZeer bg eb`am h_ ma^ k^eZmbo^er ab`a gnf[^k h_ oZkbZgml Zg] ma^ _Z\m maZm ^qik^llbhg e^o^el Zelh Zii^Zk mh [^ ab`a bg [hma ?XOIN[XOY li^\b^l) Okng\Zm^] o^klbhgl h_ ma^ <>aM ln[ngbml PI>(1. Zg] <>M(3 aZo^ [^^g bfieb\Zm^] bg k^lblmZg\^ mh e^oZfblhe^ V32W Zg] mkng\Zm^] NGJ(, ln[ngbml fb`am aZo^ ]hfbgZgm g^`Zmbo^ ^__^\ml b_ ma^r Zk^ Z[e^ mh a^m^khf^kbl^ pbma _nee(e^g`ma ln[ngbml [nm ik^o^gm ma^ _hkfZmbhg h_ Z _neer _ng\mbhgZe \aZgg^e) OaZm mkng\Zm^] \aZgg^e Zk^ ^qik^ll^] bg oZkbZgml h_ [hma' ?Y[ NGJ),), Zg] ?S[ NGJ(,)-' Zg] Zk^ ZiiZk^gmer fhk^ _k^jn^gm Zm e^Zlm bg lhf^ ]^o^ehif^gmZe lmZ`^l Zg] phkf mblln^l maZg hma^kl ln``^lml maZm ma^l^ oZkbZgml fb`am aZo^ Z iarlbheh`b\Ze _ng\mbhg' i^kaZil bg fh]neZmbg` ma^ Z\mbobmr h_ _nee(e^g`ma `^g^ ikh]n\ml) Hhk^ ]^mZbe^] ^qi^kbf^gml Zeehpbg` lmZmblmb\Ze ZgZerl^l h_ lmZ`^( Zg] mblln^(li^\b_b\ ]b__^k^g\^l k^`Zk]bg` lieb\^ oZkbZgml Zl p^ee Zl fhk^ ]^mZbe^] liZmbZe ZgZerlbl ^qik^llbhg lbm^l h_ bg]bob]nZe lieb\^ oZkbZgml pbee [^ k^jnbk^]) Oh ]^m^kfbg^ ma^ _ng\mbhg h_ mblln^(li^\b_b\ lieb\^ oZkbZgml' k^\hf[bgZgm ^qik^llbhg lrlm^fl Zeehpbg` \hf[bg^] ^qik^llbhg h_ _nee(e^g`ma Zg] mkng\Zm^] \aZgg^e oZkbZgml lahne] [^ nl^]) Oa^ _Z\m maZm m^fihkZe Zl p^ee Zl liZmbZe oZkbZmbhg h_ lieb\bg` bl JK LGIZU ebfbm^] mh ?Y[ NGJ( ,), ln``^lml maZm mabl lieb\^ oZkbZgm bl ng]^k e^ll lmkbg`^gm ^ohenmbhgZkr ik^llnk^ maZg ?Y[ NGJ( ,)-) < fhk^ ]^mZbe^] liZmbh(m^fihkZe ib\mnk^ h_ ma^ ^qik^llbhg iZmm^kg h_ ma^ lieb\^ oZkbZgml phne] a^ei ]^_bg^ ma^bk iarlbheh`b\Ze khe^l)

Dg \hg\enlbhg' ma^l^ ]ZmZ lahp maZm ma^ NGJ(, \aZgg^e h_ 1# KRKMGTY bl Z ]bk^\m mZk`^m h_ ^fh]^ilb]^ Zg] maZm ma^ \aZgg^e bl ik^l^gm bg ^o^kr bfihkmZgm `khni h_ iZkZlbmb\ g^fZmh]^l h_ o^km^[kZm^l) N^jn^g\^ ]bo^klbmr h_ NGJ(, \aZgg^el Zfhg` ma^l^ `khnil Zg] pbmabg li^\b^l bgoheo^l l^o^kZe Zem^kgZmbo^ lieb\^ oZkbZgml Zg] `^g^ ]nieb\Zmbhgl) Dgm^kZ\mbhgl h_ ln[ngbm blh_hkfl Zg] ^__^\ml hg \aZgg^e iarlbheh`r Zg] ]kn` lnl\^imb[bebmr Zk^ bfihkmZgm Zli^\ml _hk fhk^ k^l^Zk\a hg g^fZmh]^ g^nkh[bheh`r Zg] iZkZlbmheh`r)

-+2 1NGVZKX +

.&. ESTS`S\QSa

,) @edbgl O' BZg^msdr =' Rn >A' ,431' < 2XUYUVNORG fnmZmbhg maZm ^ebfbgZm^l Z \Ze\bnf(]^i^g]^gm ihmZllbnf \nkk^gm) Kkh\ IZme <\Z] N\b P N < 3.' 3/,0(3/,4) -) MhafZgg FI' ?^bm\a^k ?G' =Zll Ze\bnf(Z\mboZm^] ihmZllbnf #=F$ \aZgg^el Zk^ ^g\h]^] [r ]nieb\Zm^ leh, `^g^l bg m^e^hlm _bla^l) Hhe =bhe @ohe -1' ,0+4(,0-,) .) OZh L' F^eer H@' ,441' >Ze\bnf(Z\mboZm^] ihmZllbnf \nkk^gm bg \nemnk^] kZ[[bm k^mbgZe ib`f^gm ^ibma^ebZe \^eel) >nkk @r^ M^l ,0' -.2(-/1) /) Fbf C' Kb^k\^(NabfhfnkZ EO' Ja CE' Ehaglhg =@' Bhh]fZg H=' H\Dgmbk^ NG' -++4' Oa^ ]rlmkhiabg \hfie^q \hgmkhel [d \aZgg^e eh\ZebsZmbhg Zg] fnl\e^ Z\mbobmr bg 1GKTUXNGHJOZOY KRKMGTY ) KGhN B^g^m 0' ^,+++23+) 0) Rhelm^gahef^ a^f -32' /+-.-( /+-.3) 1) Zk[Zeeb]h E' =^g^]bmh N' BZk\bZ(NZ\kblmZg <' Kkb^mh ?' C^kgZg]^s H' -+,-' @g]hma^ebg @O#=$ k^\^imhkl Zk^ bgoheo^] bg ma^ k^eZqZmbhg mh ma^ ib` nkbgZkr [eZ]]^k g^\d) I^nkhnkhe Pkh]rg) .,' 133(14/) 2) BeZnl^k ?<' Ehaglhg =@' hfie^f^gmZmbhg h_ iarlbheh`b\Ze Zg] [^aZobhkZe ]^_^\ml [r Z lehpihd^ >Z -& ( Z\mboZm^] F & \aZgg^e mkZgl`^g^) E I^nkh\a^f 20' ,.,+(,.,4) ,+) Ol^g`(>kZgd E' Ahlm^k >?' FkZnl^ E?' H^kms M' Bh]bghm I' ?b>abZkZ OE' M^bgaZkm KC #,44/$ >ehgbg`' ^qik^llbhg' Zg] ]blmkb[nmbhg h_ _ng\mbhgZeer ]blmbg\m >Z -& (Z\mboZm^] F & \aZgg^e blh_hkfl _khf anfZg [kZbg) I^nkhg ,.' ,.,0(,..+) ,,) =k^gg^k M' Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e `^g^ ^qik^llbhg bg ma^ fb]`nm h_ 2XUYUVNORG ) >hfi =bh\a^f Karlbhe = =bh\a^f Hhe =bhe ,,3' /,,( /-+)

-+3 3SUJKVYOJK GTJ >8;"&

,-) =haf M<' RZg` =' =k^gg^k M' Z -& ( Z\mboZm^] F & \aZgg^e ^qik^llbhg5 b]^gmb_b\Zmbhg h_ Z l^\hg]' ^ohenmbhgZkber \hgl^ko^]' g^nkhgZe ikhfhm^k) E @qi =bhe -+.' 14.(2+/) ,.) =^bl^e FR' Mh\aZ(NZg\a^s NH' Ub^`^g[^bg NE' Hhkkbl F<' FZb >' FZpZb E' >Zkgbg\b K' CZrZlabsZdb T' ?Zobl MG' -++2' ?bo^klbmr h_ >Z -& (Z\mboZm^] F & \aZgg^e mkZgl\kbiml bg bgg^k ^Zk aZbk \^eel) B^g^ .31' ,,(-.) ,/) >abn TC' ' Fbf @T' ?kr^k N@' -+,+' ?hfbgZgm(g^`Zmbo^ k^`neZmbhg h_ \^ee lnk_Z\^ ^qik^llbhg [r Z i^gmZi^imb]^ fhmb_ Zm ma^ ^qmk^f^ >JJC m^kfbgnl h_ Zg Neh, \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e lieb\^ oZkbZgm) Hhe KaZkfZ\he 22' /42( 0+2) ,0) ?Zb N' CZee ??' C^ee ER' -++4' NnikZfhe^\neZk Zll^f[eb^l Zg] eh\Zebs^] k^`neZmbhg h_ ohemZ`^(`Zm^] bhg \aZgg^el) Karlbhe M^o 34' /,,(/0-) ,1) ObZg G' E^__kb^l J' H\>eZ__^kmr C' Hhero]Zl <' Mhp^ D>' NZe^^f A' >a^g G' Bk^Zo^l E' >aZf[^keZbg GC' FgZnl CB' Mnma K' Nabilmhg HE' -++3' KZefbmhreZmbhg `Zm^l iahliahkreZmbhg(]^i^g]^gm k^`neZmbhg h_ =F ihmZllbnf \aZgg^el) Kkh\ IZme <\Z] N\b ,+0' -,++1(-,+,,) ,2) Gbn L' >a^g =' B^ L' RZg` UR' -++2' Kk^lrgZimb\ >Z -& *\Zefh]nebg(]^i^g]^gm ikhm^bg dbgZl^ DD fh]neZm^l g^nkhmkZglfbmm^k k^e^Zl^ [r Z\mboZmbg` =F \aZgg^el Zm 1GKTUXNGHJOZOY KRKMGTY g^nkhfnl\neZk cng\mbhg) E I^nkhl\b -2' ,+/+/(,+/,.) ,3) Che]^g(?r^ G' J">hgghk Q' Chii^k I<' RZed^k ME' CZk]^k <' =nee F' Bn^lm H' -++2' NGJ' NGJ' jnb\d' jnb\d' lehp5 \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^el Zl k^`neZmhkl h_ 1GKTUXNGHJOZOY KRKMGTY [^aZobhnk Zg] mZk`^ml _hk Zgma^efbgmb\l) Dgo^km I^nkhl\b 2' ,44(-+3) ,4) Ehaglhg =@' BeZnl^k ?<' ?Zg(BeZnl^k @N' CZeebg` ?=' hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' hgghk Q' CZk]^k <' Che]^g(?r^ G' Chii^k I<' -++2' Oa^ \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e' NGJ(,' bl k^jnbk^] _hk ma^ Z\mbhg h_ ma^ gho^e \r\ehh\mZ]^ilbi^imb]^ Zgma^efbgmb\' ^fh]^ilb]^' bg 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' ,022(,033)

-+4 1NGVZKX +

--) R^es >' Fk{`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fk{\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+) -.) >kbl_hk] <' HnkkZr >' J">hgghk Q' @]pZk]l ME' Fk{`^k I' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -+,,' N^e^\mbo^ mhqb\bmr h_ ma^ Zgma^efbgmb\ ^fh]^ilb]^ k^o^Ze^] [r a^m^kheh`hnl ^qik^llbhg h_ anfZg F>IH<, bg 1GKTUXNGHJOZOY KRKMGTY ) Hhe KaZkfZ\he 24' ,+.,(,+/.) -/) Che]^g(?r^ G' >kbl_hk] <' R^es >' ohg NZflhg(Cbff^elmc^kgZ B' RZed^k ME' J">hgghk Q' -+,-' Rhkfl mZd^ mh ma^ leh eZg^5 Z i^kli^\mbo^ hg ma^ fh]^ h_ Z\mbhg h_ ^fh]^ilb]^) Dgo^km I^nkhl\b ,-' -4(.1) -0) HZkmbg ME' =nqmhg NF' I^o^n >' >aZko^m >G' Mh[^kmlhg eho^k M' Mn_^g^k G' =hnob^k E' R^[^k NN' R^g`^k <' Rb^eZg](=^k`aZnl^g N' Bh^[^e O' BZnokr I' KZnmkZm A' Ndkbildr O' Akh^eb\a J' Fhfhbg(JdZ >' R^lmeng] =' Nen]^k <' HZl^k K' -++3' < g^p \eZll h_ Zgma^efbgmb\l ^__^\mbo^ Z`Zbglm ]kn`(k^lblmZgm g^fZmh]^l) IZmnk^ /0-' ,21(,3+) -4) =eZqm^k HG' ?^ G^r K' BZk^r EM' Gbn GS' N\a^e]^fZg K' Qb^klmkZ^m^ <' QZg_e^m^k^g EM' HZ\d^r GT' ?hkkbl H' Akbll^ GH' Qb]Z EO' OahfZl RF' ,443' < fhe^\neZk ^ohenmbhgZkr _kZf^phkd _hk ma^ iarenf I^fZmh]Z) IZmnk^ .4-' 2,(20) .+) SbZh NC' Pmsbg`^k E' OZgg^k H' F^bl^k E' Sn^ E' -+,.' <]oZg\^l pbma ma^ >abg^l^ Zgma^efbgmab\ ]kn` mkb[^g]bfb]bg^ bg \ebgb\Ze mkbZel Zg] eZ[hkZmhkr bgo^lmb`Zmbhgl) <\mZ Okhi ,-1' ,,0(,-1) .,) Fned^ ?' Fk{\d^g E' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,/' @__b\Z\r h_ \r\ehh\mZ]^ilbi^imb]^l Zg] Zfbghia^greZfb]bg^l Z`Zbglm eZkoZe' bffZmnk^ Zg] fZmnk^ Z]nem lmZ`^l h_ Z iZkZlbmheh`b\Zeer \aZkZ\m^kbs^] mkb\ankhlbl fh]^e bg fb\^) KGhN I^`e Okhi ?bl 3' ^-143)

-,+ 3SUJKVYOJK GTJ >8;"&

.-) NZ`^k C' Chldbg` =' =Zilm =' Nm^bg K' QZgah__ F' FZfbgldr M' -++4' @__b\Z\r h_ ma^ Zfbgh(Z\^mhgbmkbe^ ]^kboZmbo^' fhg^iZgm^e' Z`Zbglm ^qi^kbf^gmZe Zg] gZmnkZe Z]nem lmZ`^ `Zlmkh(bgm^lmbgZe g^fZmh]^ bg_^\mbhgl bg la^^i) Q^m KZkZlbmhe ,04' /4(0/) ..) Okbmm^g G' Nbe[^k^bl^g <' F^bl^k E' -+,,' Dg obmkh Zg] bg oboh ^__b\Z\r h_ Hhg^iZgm^e #H' Hbmk^oZ H' -+,-' I^fZmh]^)g^m ni]Zm^ -+,,5 Z]]bmbhg h_ ]ZmZ l^ml Zg] mhhel _^Zmnkbg` g^qm(`^g^kZmbhg l^jn^g\bg` ]ZmZ) In\e^b\ <\b]l M^l /+' 2-+(2-3) /,) Ba^]bg @' RZg` N' Nibkh ?' >Ze^k @' UaZh L' >kZ[mk^^ E' k^Zlr O' Zkehp >F' >kZp_hk] HE' ?Zn[ E' ?bffb\ HR' @lm^l >A' Ahlm^k EH' BZgZmkZ H' Bk^`hkr RA' Ehaglhg IH' Ebg E' Fhfngb^\db M' Fhk_ D' FnfZk N' GZg^r N' Gb =R' Gb R' Gbg][ehf OC' Gnlmb`fZg N' HZ ?' HZbgZ >Q' HZkmbg ?H' H\>Zkm^k EK' H\M^rghe]l G' Hbmk^oZ H' InmfZg O=' KZkdbglhg E' K^k^`kbg(' M^g L' NZng]^kl G' Nen]^k

-,, 1NGVZKX +

<@' Nfbma F' NmZgd^ H' PggZl\a OM' RZk^ E' R^b ' NeZmdh =' =eZqm^k HG' N\hmm a^f Chii^(N^re^k .2/' ,11) /.) HZk\ae^k(=Zn^k <' Gn N' ' Ahg` EC' B^^k GT' B^^k M>' BhgsZe^l IM' BpZ]s H' Cnkpbms ?D' EZ\dlhg E?' F^ U' GZg\sr\db >E' Gn A' HZk\ae^k BC' HneehdZg]ho H' Jf^e\a^gdh HQ' Mh[^kmlhg >G' Nhg` EN' OaZgdb I' TZfZlabmZ M<' UaZg` ?' UaZg` I' Ua^g` >' =krZgm NC' -+,,' >??5 Z >hgl^ko^] ?hfZbg ?ZmZ[Zl^ _hk ma^ _ng\mbhgZe ZgghmZmbhg h_ ikhm^bgl) In\e^b\ <\b]l M^l .4' --0(--4) //) HZk\ae^k(=Zn^k <' =krZgm NC' -++/' >?(N^Zk\a5 ikhm^bg ]hfZbg ZgghmZmbhgl hg ma^ _er) In\e^b\ <\b]l M^l .-' .-2(..,) /0) Bhnchg H' H\RbeebZf C' Gb R' QZe^gmbg A' NjnbssZmh N' KZ^kg E' Ghi^s M' -+,+' < g^p [bhbg_hkfZmb\l ZgZerlbl mhhel _kZf^phkd Zm @H=G(@=D) In\e^b\ <\b]l M^l .3' 140(144) /1) U]h[gho @H' ZlmZ`ghg^(N^k^gh K' ?Zg\abg @B' ?^e^nkr @' K^k_nl( =Zk[^h\a G' ' >ZbeeZn] H>' >hnmbgah KH' ?ZlbeoZ >' ?^ Gn\Z A' ?^Zn A' @ljnb[^m H' Aenmk^ O' Bhe]lmhg^ EQ' CZfZfhn\a I' C^p^sb O' EZbeehg J' En[bg >' G^hg^mmb K' HZ`ebZgh H' HZb^k OM' HZkdho BQ' H\Q^b`a K' K^lhe^ B' KhneZbg E' Mh[bglhg(M^\aZob H' NZee^m @' N^`nk^gl =' Nm^bg[Z\a ?' Orm`Zm O' P`Zkm^ @' oZg Ba^e]^k >' Q^khgb\h K' =Znf OE' =eZqm^k H' =e^o^(UZ\a^h O' ?Zobl @G' @p[Zgd EE' AZo^kr =' Bk^gb^k @' C^gkbllZm =' Ehg^l EO' GZn]^m Q' HZne^ a^ggZ M' H\B^mmb`Zg K<' H\RbeebZf C' QZe^gmbg A' RZeeZ\^ DH' Rbef <' Ghi^s M' Oahfilhg E?' Bb[lhg OE' Cb``bgl ?B' -++2' >enlmZe R Zg] >enlmZe S o^klbhg -)+) =bhbg_hkfZmb\l -.' -4/2(-4/3)

-,- 3SUJKVYOJK GTJ >8;"&

0+) ?Zkkb[Z ?' OZ[hZ]Z BG' ?hZeeh M' KhlZ]Z ?' -+,,' KkhmO^lm .5 _Zlm l^e^\mbhg h_ [^lm( _bm fh]^el h_ ikhm^bg ^ohenmbhg) =bhbg_hkfZmb\l -2' ,,1/(,,10) 0,) ' BZl\n^e J' -+,,' Nnko^r h_ [kZg\a lniihkm f^mah]l ]^fhglmkZm^l Z\\nkZ\r' ihp^k' Zg] kh[nlmg^ll h_ _Zlm ebd^ebahh]( [Zl^] ZiikhqbfZmbhg l\a^f^l) Nrlm =bhe 1+' 130(144) 0-) Bnbg]hg N' ?n_ZrZk] EA' G^_hkm Q' hfinm ZgmZ\^llb >' Thng` I?' I^clnf K' E^q Zfi[^ee =@' CZee MN' OaZfl[hk` NH' N\a^^kebg\d EK' BZll^k M=' -+,,' Oa^ mkZgl\kbimhf^ h_ ?XOIN[XOY Y[OY ( _bklm fhe^\neZk bglb`aml bgmh Z iZkZlbm^ pbma \nkZmbo^ ikhi^kmb^l _hk d^r bffng^ ]bl^Zl^l h_ anfZgl) KGhN Jg^ 1' ^-.04+) 02) N\anes HC' U^k[bgh ?M' Qbg`khg H' =bkg^r @' -+,-' JZl^l5 kh[nlm ]^ ghoh MI<( l^j Zll^f[er Z\khll ma^ ]rgZfb\ kZg`^ h_ ^qik^llbhg e^o^el) =bhbg_hkfZmb\l -3' ,+31( ,+4-) 03) U^k[bgh ?M' -+,+' Plbg` ma^ Q^eo^m ]^ ghoh Zll^f[e^k _hk lahkm(k^Z] l^jn^g\bg` m^\agheh`b^l) >nkk Kkhmh\ =bhbg_hkfZmb\l >aZim^k ,,5 Pgbm ,,(,0) 04) >a^g =' B^ L' SbZ SH' Gbn K' RZg` NE' UaZg C' @bii^k =<' RZg` UR' -+,+' < gho^e ZnqbebZkr ln[ngbm \kbmb\Ze mh =F \aZgg^e _ng\mbhg bg 1GKTUXNGHJOZOY KRKMGTY ) E I^nkhl\b .+' ,110,(,111,) 1+) >a^g R' O^kZ]Z H' >a^g` EO' ,441' >aZkZ\m^kbsZmbhg h_ ln[mri^l h_ `ZffZ( Zfbgh[nmrkb\ Z\b] k^\^imhkl bg Zg /YIGXOY fnl\e^ ik^iZkZmbhg [r [bg]bg` ZllZr Zg] [bg]bg` h_ KA,+--<' Z g^p Zgma^efbgmb\' hg ma^ k^\^imhkl) KZkZlbmhe M^l 3-' 42(,+,)

-,. 1NGVZKX +

1,) Rbeelhg E' hhd <' >nmme^ HA' Fkb^d I' Chii^k I<' J">hgghk Q' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -++/' GZmkhmhqbg k^\^imhk lb`gZebg` ^g`Z`^l ma^ PI>(,.(]^i^g]^gm o^lb\e^(ikbfbg` iZmapZr bg 1# KRKMGTY ) >nkk =bhe ,/' ,.2/( ,.24) 1-) =nqmhg NF' I^o^n >' >aZko^m >G' Mh[^kmlhg ' >he^l B>' -++0' @__b\Z\r h_ mph \r\ehh\mZ]^ilbi^imb]^l' KA,+--< Zg] ^fh]^ilb]^' Z`Zbglm Zgma^efbgmb\(k^lblmZgm g^fZmh]^l bg la^^i Zg] \Zmme^) KZkZlbmheh`r ,.+' ./.(./2) 1/) CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++-' >r\ehh\mZ]^ilbi^imb]^l ( Z g^p \eZll h_ Zgma^efbgmb\Zeer Z\mbo^ \hfihng]l) KZkZlbmhe M^l 33' /3,(/33) 10) Bh]^e >' -+,-' ?kn` mZk`^ml h_ ma^ a^Zkmphkf' " 2OXULORGXOG OSSOZOY ") Ka? ma^lbl' Pgbo^klbmr h_ =Zl^e' =Zl^e' Npbms^keZg]) 11) Gbmme^ KM' Ch]`^l <' RZmlhg OB' N^^] E<' HZ^]^k NE' -+,+' Ab^e] ^__b\Z\r Zg] lZ_^mr h_ Zg hkZe _hkfneZmbhg h_ ma^ gho^e \hf[bgZmbhg Zgma^efbgmb\' ]^kjnZgm^e(Z[Zf^\mbg' bg la^^i bg I^p U^ZeZg]) I U Q^m E 03' ,-,(,-4) 12) F^bl^k E' Pmsbg`^k E' -+,+' Oa^ ]kn`l p^ aZo^ Zg] ma^ ]kn`l p^ g^^] Z`Zbglm fZchk a^efbgma bg_^\mbhgl) <]o KZkZlbmhe 2.' ,42(-.+) 13) JeebZkh K' N^be^k E' Fn^l^e <' Chkmhg E' >eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) 14) Kkb\aZk] MF' =ZlZg^s HB' =hZmbg =<' H\>Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 1' ^,0/4) 2+) Ohpglhg N' Ak^^fZg <' CZkkbl <' CZk]^k <' -++0' <\bmbomr h_ ma^ \r\ehh\mZ]^ilbi^imb]^ ^fh]^ilb]^ Z`Zbglm ;TINUIKXIG M[ZZ[XUYG ' ;TINUIKXIG ROKTGROY Zg] 0X[MOG VGNGTMO )

-,/ 3SUJKVYOJK GTJ >8;"&

2-) UZag^k C' OZn[^km <' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++,' AbeZkb\b]Ze ^__b\Z\r h_ ma^ Zgma^efbgmb\Zeer Z\mbo^ \r\eh]^ilbi^imb]^l) Dgm E KZkZlbmhe .,' ,0,0( ,0--) 2.) K^mkr B' aZke^l N' >knma^kl G' Fhd ?E' FkZ^f^k A' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ Z]nem ?XOIN[XOY \[RVOY bg_^\mbhgl bg ]h`l) KZkZlbmhe M^l ,+0' ,2(--) 20) N\afZae B' H^aeahkg C' CZk]^k <' Febfi^e N' Fkb^`^k F' -++2' @__b\Z\r h_ Z \hf[bgZmbhg h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e Z`Zbglm eZkoZe Zg] Z]nem lmZ`^l h_ g^fZmh]^l # ?XOIN[XOY S[XOY ' /TMOUYZXUTM_R[Y IGTZUTKTYOY $ bg kh]^gml) KZkZlbmhe M^l ,+,' 22(3/) 21) H^aeahkg C' N\afZae B' Ak^l^ H' H^obll^g D' CZk]^k <' Fkb^`^k F' -++0' @__^\ml h_ Z \hf[bgZmbhgl h_ ^fh]^ilb]^ Zg] ikZsbjnZgm^e hg iZkZlbm^l h_ k^imbe^l Zg] kh]^gml) KZkZlbmhe M^l 42' 10(14) 22) =khpg ??' Nb]]bjnb NU' FZcb H?' Ahkk^lm^k NB' -+,-' KaZkfZ\heh`b\Ze \aZkZ\m^kbsZmbhg h_ ma^ 6GKSUTIN[Y IUTZUXZ[Y B<=<(`Zm^] \aehkb]^ \aZgg^e' 6IU ( PI>(/45 fh]neZmbhg [r fZ\kh\r\eb\ eZ\mhg^ Zgma^efbgmb\l Zg] Z k^\^imhk _hk ibi^kZsbg^) Q^m KZkZlbmhe ,30' -+,(-+4) 23) =nqmhg NF' >aZko^m >G' I^o^n >' >Z[Zk^m E' >hkm^m E' K^bg^Zn I' <[hg`pZ H' >hnkmhm @' Mh[^kmlhg aMl) KGhN KZmah` ,+' ^,++.32+) 24) Ahkk^lm^k NB' Kkb\aZk] MF' ?^gm E<' =^^\a MI' -++.' 6GKSUTIN[Y IUTZUXZ[Y 5 6I Ben>eZ ^qik^ll^] bg CKTUV[Y hh\rm^l _hkfl Z `enmZfZm^(`Zm^] bhg \aZgg^e maZm bl Z\mboZm^] [r b[hm^gZm^ Zg] ma^ ZgmbiZkZlbmb\ ]kn` bo^kf^\mbg) Hhe =bh\a^f KZkZlbmhe ,-4' ,,0(,-,) 3+) =bZg\ab G' ?kbl\hee H' -++1' C^m^kheh`hnl ^qik^llbhg h_ 1# KRKMGTY bhg \aZgg^el bg CKTUV[Y hh\rm^l) Rhkf=hhd' ,(,1) 3,) ?n_hnk Q' =^^\a MI' R^o^k >' ?^gm E<' B^Zkr OB' -+,.' Hhe^\neZk \ehgbg` Zg] \aZkZ\m^kbsZmbhg h_ gho^e `enmZfZm^(`Zm^] \aehkb]^ \aZgg^e ln[ngbml _khf >INOYZUYUSG SGTYUTO ) KGhN KZmah` 4' ^,++.031)

-,0 1NGVZKX +

3-) B^g` T' RZg` S' HZ`e^[r FG' -+,.' GZ\d h_ g^`Zmbo^ lehi^ bg D(Q iehml _hk =F \aZgg^el Zm ihlbmbo^ ihm^gmbZel bg ma^ Z[l^g\^ h_ bgmkZ\^eeneZk [eh\d^kl) E B^g Karlbhe ,/,5 /4.(/42) 3.) B{gs^e ?' Fn\aZkldb GH' F^ak^l ?B' Mhf^kh HA' HZ`nbk^ H@' -++1' Oa^ H`m> obkne^g\^ _Z\mhk h_ >GRSUTKRRG KTZKXOIG YKXU\GX ?_VNOS[XO[S Z\mboZm^l IZ &' F &( kbl_hk]' <' -+,,' ' =eZqm^k HG' Mh`^kl Ze\bnf Z\mboZmbhg h_ =F#>Z$ ihmZllbnf \aZgg^el eZ\dbg` ma^ \Ze\bnf [hpe Zg] M>F ]hfZbgl) IZmnk^ /-+' /44(0+-) 32) HZkmbg ME' Mh[^kmlhg aZko^m >G' I^o^n >' -+,-' G^oZfblhe^ k^\^imhkl5 Z l^\hg] ZpZd^gbg`) Ok^g]l KZkZlbmhe -3' -34(-41)

-,1 3SUJKVYOJK GTJ >8;"&

.&/ Fc^^]`bW\U W\T]`[ObW]\

Fc^^ZS[S\bO`g GOP& .%*& ?^mZbel _hk NGJ(, \aZgg^e ikhm^bg l^jn^g\^l nlbg` _hk

iareh`^g^mb\ ZgZerlbl Zg] b]^gmb_b\Zmbhg h_ lieb\^ oZkbZgml

4[W\] @]ZSQcZO` FgabS[ObWQ F^SQWSa C`]bSW\ OQWR eSWUVb ^< 4QQSaaW]\ \]& O ^]aWbW]\ ZS\UbV !Y7O" 1GKTUXNGHJOZOY >akhfZ]hk^Z 1KR NGJ(,Z ,,/+ ,-4)0 0)20 IKX++,+-/-04 KRKMGTY MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 1GKTUXNGHJOZOY >akhfZ]hk^Z 1KR NGJ(,[ ,,,3 ,-2)+ 0)12 IKX++,+-/-1+ KRKMGTY MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 1GKTUXNGHJOZOY >akhfZ]hk^Z 1KR NGJ(,\ ,,., ,-3)1 0)03 IKX++,+-/-1, KRKMGTY MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 1GKTUXNGHJOZOY >akhfZ]hk^Z 1HX NGJ(, ,,/- ,-4)2 0)14 SKX-1.3/4. HXOMMYGK MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 1GKTUXNGHJOZOY >akhfZ]hk^Z 1XK NGJ(, ,,12 ,.-)1 0)22 SKX++.+4/./2 XKSGTKO MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 6GKSUTIN[Y >akhfZ]hk^Z 6IU NGJ(, ,,+0 ,-0)- 0)22 <=N/0+13 IUTZUXZ[Y MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q 1UUVKXOG >akhfZ]hk^Z 1UT NGJ(, ,,,, ,-0)4 0)3+ <=N/0+14 UTIUVNUXG MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q /TI_RUYZUSG >akhfZ]hk^Z /IG NGJ(, ,,,1 ,-1)2 0)// <>>133/- IGTOT[S MaZ[]bmb]Z MaZ[]bmhb]^Z \eZ]^ Q

-,2 1NGVZKX +

akhfZ]hk^Z ZXUTM_RUOJKY >akhfh]hk^Z >XG NGJ(, ,,2+ ,.,)/ 0)0, Nk.-,X+S++,.1 \ XGZZO MaZ[]bmb]Z ++)m,

KZgZ`kheZbfhb]^Z >eZ]^ DQ 9KRUOJUM_TK >akhfh]hk^Z 9OT NGJ ", ,,-+ ,-1)/ 0).4 Hbg\+/+21Z ] OTIUMTOZG Ore^g\ab]Z >eZ]^DQ 2OXULORGXOG >akhfZ]hk^Z 2OS NGJ(,Z ,,,4 ,-1)2 0)-2 akhfZ]hk^Z 2OS NGJ(,[ ,,+/ ,-0)+ 0)// akhfZ]hk^Z ;M[ NGJ(, ,,,4 ,-1)3 0)-2 akhfZ]hk^Z 0SG NGJ(,\ ,,,0 ,-1). 0),4 =H12,4\ [ SGRG_O Nibknkb]Z \eZ]^ DDD 0X[MOG >akhfZ]hk^Z 0SG NGJ(,] ,,.- ,-3)- 0).4 =H12,4] [ SGRG_O Nibknkb]Z \eZ]^ DDD 0X[MOG >akhfZ]hk^Z 0SG NGJ(,^ ,+24 ,--). 0).+ =H12,4^ [ SGRG_O Nibknkb]Z \eZ]^ DDD 0X[MOG >akhfZ]hk^Z 0SG NGJ(,_ ,,+/ ,-0), 0)/+ =H12,4_ [ SGRG_O Nibknkb]Z FE0.,--- \eZ]^ DDD 0X[MOG >akhfZ]hk^Z 0SG NGJ(,` ,+32 ,-.)- 0),4 =H12,4` [ SGRG_O Nibknkb]Z \eZ]^ DDD 0X[MOG >akhfZ]hk^Z 0SG NGJ(,a ,,+/ ,-0)+ 0)// =H12,4a [ SGRG_O Nibknkb]Z \eZ]^ DDD /YIGXOY >akhfZ]hk^Z /Y[ NGJ(, ,,,2 ,-1)/ 0)+/ <>>133/- Y[[S

-,3 3SUJKVYOJK GTJ >8;"&

akhfZ]hk^Z >133/. KW[UX[S akhfZ]hk^Z ?IG NGJ(, ,,-. ,-1)4 0).3 <>E1/2,3 IGTOY knlmZ\^Z =kZg\abZih]Z

2XUYUVNORG @\]rlhshZ ?f^NGJ(,L ,,20 ,.+). 0),. IKX++,+,/10, SKRGTUMGYZKX Dgl^\mZ ?bim^kZ

-,4 1NGVZKX +

2XUYUVNORG @\]rlhshZ 2SK NGJ(,N ,-,+ ,./)/ 0)/3 IKX++,,1.2,- SKRGTUMGYZKX

0UY Q^km^[kZmZ 0ZG NGJ(, ,,11 ,.+), 1)., IKX222,+0 ZG[X[Y HZffZebZ MnfbgZgmbZ 6USU Q^km^[kZmZ 6YG NGJ(, ,-.1 ,.0)1 1)1/ IKX++,,0/3-/ YGVOKTY HZffZebZ KkbfZm^l

ZD_ ghm _nkma^k li^\b_b^] ikhm^bg Z\\^llbhg gnf[^kl _khf B^g=Zgd Zk^ `bo^g) [Dg Rhkf=Zl^) \Dg NZg`^k ># XGZZO `^ghf^ ]ZmZ[Zl^) ]Dg DIM< 9# OTIUMTOZG `^ghf^ ]ZmZ[Zl^) ^< _nee(e^g`ma \hgl^glnl l^jn^g\^ pZl [nbem _khf ma^l^ ^gmkb^l)

--+ 3SUJKVYOJK GTJ >8;"&

Fc^^ZS[S\bO`g GOP& .%+& Kkbf^k l^jn^g\^l' pab\a p^k^ nl^] mh Zfieb_r _nee(e^g`ma l^jn^g\^l h_ iZkZlbmb\ g^fZmh]^ leh(, \?I

Zem^kgZmbo^ lieb\bg` h_ ?# S[XOY leh(,),

GO`USb aS_cS\QS C`W[S` \O[S C`W[S` aS_cS\QS 0# SGRG_O leh(, =f leh(, Anee _hk 0$( B B<< BB< OB< B>B (. $ Anee(e^g`ma l^jn^g\^ =f leh(, Anee k^o 0$( > <>< B >>O BB< O>> BBO (. $ Anee(e^g`ma l^jn^g\^ ?b leh(, Anee k^o 0$( O<> OO BO< >> ><< BOO OB< BBO O< >B> ><< O>> B>> B <BB BO> B> <>> <>O > O< (. $ Anee(e^g`ma l^jn^g\^ K^ leh(, Anee k^o 0$( <BO OBB BO> < BOB <>> BOB O>O OB (. $ Anee(e^g`ma l^jn^g\^ O\ leh(, Anee k^o 0$( >B< BB OOO >O> (. $ ?# S[XOY leh(,),Z*[*\*] Of leh(,), Anee _hk 0$( <<> OO> OO> OO> >>B >BO OBB <>> OO> >>> BOB BO> O<> OBO O>< OBO OO> BOO(.$ ?# S[XOY leh(,)- Of leh(,)- Anee _hk 0$( >>O O>> BO> <>< BOO >< O>B OOO >B> > (. $ ?# S[XOY leh(,), Of leh(,), D@< _hk 0$( <>> OBO OOB >O< OB> B>O >B (. $ Nieb\^ l^jn^g\^ Of leh(,), D@< k^o 0$( >OB >< (. $

--, 1NGVZKX +

Fc^^ZS[S\bO`g 9WU& .%0& >nkk^gml h[mZbg^] _khf ?# S[XOY leh(,),Z bgc^\m^] hh\rm^l >nkk^gml h[mZbg^] _khf hh\rm^l bgc^\m^] pbma pZm^k hk ?S[ leh(,),Z \MI< bg ma^ Z[l^g\^ h_ Zgr ]kn` #[ZlZe$ hk bg ma^ ik^l^g\^ h_ ,+ H ^fh]^ilb]^ #^fh$ #g81$) Oa^ Zlm^kbld ab`aeb`aml Z lb`gb_b\Zgm ]b__^k^g\^ [^mp^^g pZm^k bgc^\m^] hh\rm^l Zg] hh\rm^l bgc^\m^] pbma ?S[ leh(,),Z ^bma^k bg ma^ Z[l^g\^ hk ik^l^g\^ h_ ^fh]^ilb]^)

---

6VO^bS` /

6][^`SVS\aWdS RWaQcaaW]\

1NGVZKX ,

/ 6][^`SVS\aWdS RWaQcaaW]\

KZkZlbmb\ a^efbgmal aZo^ Zg ^ghkfhnl' [nm h_m^g ng]^k^lmbfZm^]' bfiZ\m hg anfZg Zg] ZgbfZe a^Zema Zg] \Znl^ mk^f^g]hnl _bgZg\bZe ehll^l bg Z`kb\nemnk^ Zg] ebo^lmh\d ikh]n\mbhg V,W) Dg anfZgl ma^ fhlm ik^oZe^gm ieZmra^efbgmal Zk^ ma^ _hh]([hkg^ mk^fZmh]^l 1# YOTKTYOY! 4GYIOURG lii)' # YZKXIUXGROY V/W Zl p^ee Zl [r ma^ _beZkbZ^ ;# \UR\[R[Y! B# HGTIXULZO ' 0# SGRG_O Zg] 0# ZOSUXO V0W) Dg laZki \hgmkZlm mh ma^ lZ_^ Zg] nlnZeer ab`aer k^ebZ[e^ mk^Zmf^gm h_ bg_^\mbhgl pbma ieZmra^efbgmal' fZbger nlbg` ^bma^k ikZsbjnZgm^e hk mkb\eZ[^g]Zshe^ V1W' ma^ ]kn`l eblm^] hg ma^ RCJ eblm h_ ^ll^gmbZe f^]b\bg^l _hk ma^ mk^Zmf^gm h_ g^fZmh]^ bg_^\mbhgl Zk^ bgln__b\b^gmer ^__^\mbo^) Oa^ mak^^ eblm^] ]kn`l _hk ma^ mk^Zmf^gm h_ _beZkbhlbl' Ze[^g]Zshe^' ]b^mare\Zk[ZfZsbg^ Zg] bo^kf^\mbg' Zk^ k^ihkm^] mh [^ ab`aer ^__^\mbo^ Z`Zbglm fb\kh_beZkbZ^' pa^k^Zl ihhk fZ\kh_beZkb\b]bZe ^__b\Z\b^l p^k^ h[l^ko^] pa^g Z]fbgblm^kbg` bg ni mh mph ]hl^l V2W) Dg Z]]bmbhg' \h(^g]^fb\bmr h_ ;# \UR\[R[Y Zg] GA pbma 8# RUG ikhab[bml mk^Zmf^gm pbma bo^kf^\mbg ]n^ mh ma^ kbld h_ ^g\^iaZehiZmar \Znl^] [r fb`kZmbg` fb\kh_beZkbZ^ h_ 8# RUG V3W) Oa^ [^gsbfb]Zshe^l' Ze[^g]Zshe^ Zg] f^[^g]Zshe^' Zl p^ee Zl ma^ \ahebg^k`b\ ]kn`l' e^oZfblhe^ Zg] irkZgm^e' mZk`^mbg` ma^ `Zlmkhbgm^lmbgZe g^fZmh]^l' Zk^ nlnZeer ab`aer ^__^\mbo^ Z`Zbglm /# R[SHXOIUOJKY bg Z lbg`e^ ]hl^ k^`bf^g' pa^k^Zl Zm e^Zlm fnembie^ ]hlZ`^l Zk^ k^jnbk^] mh \nk^ ahhdphkf' mak^Z]phkf Zg] iZkmb\neZker pabiphkf bg_^\mbhgl V4',+W) Dg o^m^kbgZkr f^]b\bg^' bg_^\mbhgl pbma a^efbgmal h_ fZchk k^e^oZg\^ Zk^ `^g^kZeer \Znl^] [r li^\b^l [^ehg`bg` mh ma^ lZf^ mZqZ Zl ma^ anfZg iZmah`^gl) Oanl' bg \hfiZgbhg ZgbfZel Zg] ebo^lmh\d ma^ fhlm ik^oZe^gm \^lmh]^l [^ehg` mh ma^ >r\ehiareeb]^Z Zg] ma^ fhlm \hffhg g^fZmh]^l [^ehg` mh ma^ Nmkhg`reb]Z'

--/ 1USVXKNKTYO\K JOYI[YYOUT

Zg] pabiphkfl bg Z lbg`e^ ]hl^ k^`bf^g) Chp^o^k' mk^Zmf^gm himbhgl Zg] ^li^\bZeer ik^o^gmbhg h_ iZm^gm 2# OSSOZOY bg_^\mbhgl Zk^ eZk`^er ebfbm^] mh fZ\kh\r\eb\ eZ\mhg^l Zg] ]n^ mh k^\^gmer bg\k^Zlbg` k^ihkml h_ k^lblmZg\^ V,-W' ma^ lnlmZbgZ[e^ \hgmkhe h_ a^Zkmphkf ]bl^Zl^ bg ]h`l fb`am [^ Zm kbld bg ma^ g^Zk _nmnk^) Dg \hgmkZlm' bg `kZsbg` ZgbfZel bg\en]bg` \Zmme^' la^^i' `hZm Zg] ahkl^l Zgma^efbgmb\ k^lblmZg\^ bl pb]^lik^Z]' ghm hger Z__^\mbg` Z eZk`^ gnf[^k h_ g^fZmh]^ li^\b^l [nm Zelh Zee \hffhger nl^] ]kn` \eZll^l V,.(,1W) Oanl' ma^ nk`^gm ]^fZg] _hk g^p Zgma^efbgmb\l bl h[obhnl) =^lb]^l Z lfZee gnf[^k h_ hma^kl' ma^ \r\ehh\mZ]^ilbi^imb]^l V4' ,/W Zg] ma^ Zfbghia^greZfb]bg^l V,2W Zk^ \hglb]^k^] Zl o^kr ikhfbg^gm ]kn` \eZll^l _hk _nkma^k ^oZenZmbhg Zl [khZ](li^\mknf Zgma^efbgmb\l Zg] _hk ma^ Z]fbllbhg hg ma^ RCJ eblm h_ ^ll^gmbZe f^]b\bg^l) Oa^k^_hk^' ma^ ik^l^gm ma^lbl _nkma^k bgo^lmb`Zm^l Zg] \hfiZk^l ma^ ihm^gmbZe h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' mkb[^g]bfb]bg^ Zg] ]

/&) 8dOZcObW]\ ]T QSab]RWQWROZ /2 9/93 STTWQOQg ]T O[W\]^VS\gZO[WRW\Sa

<\mbobmr h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e Zg] mkb[^g]bfb]bg^ Z`Zbglm \^lmh]^l aZl Zek^Z]r [^^g in[ebla^]) Chp^o^k' ma^l^ k^ihkml p^k^ lhf^paZm bg_hkfZe) Ahk Zfb]Zgm^e'

^__b\Z\r Z`Zbglm \^kmZbg \^lmh]^l p^k^ \eZbf^] [r eblmbg` ma^ @?44 oZen^l pbmahnm Zgr phkf \hngml hk ikh\^]nk^l V-/W' pa^k^Zl _hk mkb[^g]bfb]bg^ hger Z k^ob^p f^gmbhgbg` ^__b\Z\r Z`Zbglm oZkbhnl \ab\d^g \^lmh]^l V-0W Zg] Z \ebgb\Ze _b^e] mkbZe k^ihkmbg` lhf^ ^__^\ml hg --0 1NGVZKX ,

?GKTOG lii) V-1W Zk^ ZoZbeZ[e^) Dg Z]]bmbhg mh ma^ blheZm^] k^ihkml h_ \^lmh]b\b]Ze ^__^\ml' ^__b\Z\b^l h_ Zfbghia^greZfb]bg^l Z`Zbglm mk^fZmh]^l Zg] g^fZmh]^l aZo^ _k^jn^gmer [^^g h[l^ko^] #_hk k^ob^p V-0'-2W$) < fhghma^kZir Z`Zbglm Zee mak^^ mZqZ h_ a^efbgmal' ^li^\bZeer bg Zk^Zl pa^k^ ma^r Zk^ Zee \h(^g]^fb\' phne] aZo^ lb`gb_b\Zgm Z]oZgmZ`^l bg \hfiZkblhg mh bg]bob]nZe mk^Zmf^gm h_ hger hg^ mZqhg hk Z ]kn` \hf[bgZmbhg mZk`^mbg` Zee mak^^ mZqZ' bg\en]bg` #b$ ma^ ]^\k^Zlbg` kbld h_ lb]^ ^__^\ml hk mhqb\bmr ]n^ mh ma^ Z[l^g\^ h_ Zgr ]kn` bgm^kZ\mbhgl' #bb$ ma^ k^]n\mbhg h_ l^e^\mbhg _hk k^lblmZg\^ bg \Zl^l pa^k^ [hma ]kn`l laZk^ ma^bk fh]^ h_ Z\mbhg Zg] #bbb$ k^]n\mbhg h_ \hlml Zg] fZgZ`^f^gm ^__hkml bg m^kfl h_ H?r\ehiareeb]^Z' ma^ hk]^k h_ mZi^phkfl \hgmZbgbg` ma^ fZchkbmr h_ k^e^oZgm li^\b^l bg anfZg Zg] o^m^kbgZkr f^]b\bg^) Oa^ ^__^\ml h_ ma^ Zfbghia^greZfb]bg^l pbee [^ ]bl\nll^] bg l^\mbhg 2)3' pa^k^Zl ma^ ^__^\ml h_ ma^ Z]fbgblm^k^] \hf[bgZmbhgl pbee [^ ZgZerl^] bg l^\mbhg 2),+)

/&* 8dOZcObW]\ ]T \S[ObWQWROZ /2 9/753 STTWQOQg

Oa^ \nkk^gm `he] lmZg]Zk] _hk ma^ Zll^llf^gm h_ ma^ ^__b\Z\r h_ g^p \a^fb\Ze ^gmbmb^l Z`Zbglm a^efbgmal bl ma^ nmbeblZmbhg h_ OT \OZXU ZllZrl [Zl^] hg ma^ oblnZe ^oZenZmbhg h_ phkf fhmbebmr nlbg` Z fb\khl\hi^ V-4W) Ahk lhf^ ]kn`l m^lm^] a^k^' ]b__^k^gm OT \OZXU ]ZmZ Zek^Z]r ^qblm bg ma^ ebm^kZmnk^ #_hk k^ob^p l^^ V-0'-2W _hk Zfbghia^greZfb]bg^l Zg] V.+'.,W _hk \r\ehh\mZ]^ilb(i^imb]^l$) Chp^o^k' Nfhnm KZ GR# V-4W ihbgm^] hnm' maZm ma^ oblnZe Zll^llf^gm h_ phkf fhmbebmr bl ln[c^\mbo^ Zg] ]b__b\nem mh lmZg]Zk]bl^) Oh Zeehp \hfiZkblhgl [^mp^^g ma^ ^__b\Z\b^l h_ k^li^\mbo^ ]kn`l' ma^ l^\hg] in[eb\Zmbhg #\aZim^k .$ k^ihkml hg ma^ ^__b\Z\r ^oZenZmbhg h_ ma^ ]kn`l nlbg` mph fhmbebmr ZllZrl' mZk`^mbg` ma^ kZm ahhdphkf :# HXGYOROKTYOY G. Zg] ?# YVOXGROY G,' k^li^\mbo^er) Oa^ ZllZrl p^k^ nl^] mh h[mZbg ]hl^(k^lihgl^ \nko^l _hk Zfb]Zgm^e' mkb[^g]bfb]bg^' ]

[r \hglb]^kZmbhg h_ ma^ ]bo^klbmr h_ ma^ iarenf I^fZmh]Z) Oanl' ma^ \eZ]^ D g^fZmh]^ ?# YVOXGROY Zg] \eZ]^ Q kZm ahhdphkf :# HXGYOROKTYOY p^k^ l^e^\m^]) ?# YVOXGROY [^ehg`l mh ma^ Okb\ah\^iaZeb]Z Zg] :# HXGYOROKTYOY [^ehg`l mh ma^ Nmkhg`reb]Z) =^lb]^l ma^bk iareh`^g^mb\ ]blmZg\^' [hma li^\b^l Zelh k^ik^l^gm mZqZ h_ fZchk bfihkmZg\^ _hk anfZg Zg] o^m^kbgZkr iZkZlbmheh`r) Dg Z]]bmbhg' Z _neer h[c^\mbo^ OT \OZXU ZllZr pZl i^k_hkf^]' pab\a pZl ^oZenZm^] [r nlbg` \hehnkbf^mkb\ ]^m^kfbgZmbhg h_ <>a@ Z\mbobmr V.-W' pab\a bl l^\k^m^] [r Z]nem :# HXGYOROKTYOY ) ?hl^(k^lihgl^ \nko^l h_ Zee m^lm \hfihng]l Zg] ]kn` \hf[bgZmbhgl p^k^ \Ze\neZm^] bg mak^^ OT \OZXU ZllZrl' mZk`^mbg` G, h_ ?# YVOXGROY Zl p^ee Zl G. Zg] Z]nem phkfl h_ :# HXGYOROKTYOY ) Rabe^ Zee \hfihng]l Zg] \hf[bgZmbhgl lahp^] ]hl^(]^i^g]^gm bgab[bmbhg h_ phkf Z\mbobmr' ma^ fZqbfZe bgab[bmbhg bg ma^ <>a@ l^\k^mbhg ZllZr pZl fn\a ehp^k maZg bg ma^ fhmbebmr ZllZrl) <`Zbg' ^__^\ml h_ ma^ Zfbghia^greZfb]bg^l pbee [^ ]bl\nll^] bg l^\mbhg 2)3' ma^ ^__^\ml h_ ma^ \r\ehh\mZ]^ilbi^imb]^l bg l^\mbhg 2)4 Zg] ma^ ^__^\ml h_ ma^ \hf[bgZmbhgl bg l^\mbhg 2),+)

/&+ 8dOZcObW]\ ]T \S[ObWQWROZ /2 9/93 STTWQOQg OUOW\ab #. *5)6/0/,26/6

Oh k^]n\^ ma^ oZkbZ[e^l _khf OT \OZXU mh OT \O\U ^__b\Z\r ^oZenZmbhg Zl fn\a Zl ihllb[e^' ma^ mabk] in[eb\Zmbhg #\aZim^k /$ k^ihkml hg ma^ OT \O\U ^__b\Z\r h_ ma^ m^lm \hfihng]l Zg] \hf[bgZmbhgl Z`Zbglm :# HXGYOROKTYOY bg kZml' pab\a bl ma^ lZf^ g^fZmh]^ li^\b^l \ahl^g _hk mph h_ ma^ OT \OZXU ZllZrl) :# HXGYOROKTYOY lahpl ma^ mrib\Ze eb_^ \r\e^ h_ ahhdphkfl) G. i^g^mkZm^ ma^ ldbg Zg] fb`kZm^ obZ ma^ [ehh] lrlm^f bgmh ma^ eng`l' pa^k^ ma^ fhnem mh G/ mZd^l ieZ\^) <_m^k ZiikhqbfZm^er mph ]Zrl V#O#! G/ e^Zo^ ma^ eng`l obZ ma^ mkZ\a^Z) <_m^k [^bg` lpZeehp^]' ma^ G/ _bgZeer k^Z\a ma^ lfZee bgm^lmbg^ pa^k^ ma^ _bgZe fhnem h\\nkl [^mp^^g ]Zrl _hnk Zg] _bo^ V#O# V..W) Ok^Zmf^gml p^k^ i^k_hkf^] hg ]Zrl _hnk mh lbq V#O# mh ^glnk^ `Zlmkhbgm^lmbgZe iaZl^ h_ :# HXGYOROKTYOY ) Ok^Zmf^gm Z`Zbglm fb`kZmbg` eZkoZe lmZ`^l phne] k^jnbk^ lrlm^fb\ ZoZbeZ[bebmr h_ ]kn`l) Chp^o^k' mabl phne] lb`gb_b\Zgmer Z__^\m ma^ \hfiZkblhg [^mp^^g mk^Zmf^gml nlbg` ^bma^k mkb[^g]bfb]bg^ hk ]

--2 1NGVZKX ,

Dg ma^ \hgm^qm h_ ^__b\Z\r ^oZenZmbhg' ma^ k^ikh]n\b[bebmr h_ bgh\nenf lbs^ Zg] phkf k^\ho^kr pZl bgo^lmb`Zm^]) < ab`a oZkbZ[bebmr [^mp^^g bg]bob]nZe ZgbfZel pbmabg ^Z\a [eh\d pZl lahpg6 ahp^o^k' ]b__^k^g\^l [^mp^^g [eh\dl p^k^ ghm lmZmblmb\Zeer lb`gb_b\Zgm) Oabl ng]^kebg^l ma^ k^jnbk^f^gm h_ nlbg` k^eZmbo^er ab`a gnf[^kl h_ ZgbfZel pa^g m^lmbg` Zgma^efbgmb\ ]kn`l mh h[mZbg f^Zgbg`_ne ]ZmZ) Dg Z]]bmbhg' ab`a oZkbZ[bebmr pZl Zelh h[l^ko^] _hk bgm^kf^]bZm^ ^__b\Z\r kZm^l bg ma^ ]kn` mk^Zm^] `khnil' ab`aeb`ambg` ma^ _Z\m maZm ma^ gnf[^k h_ ZgbfZel ^ll^gmbZeer \hgmkb[nm^l mh ma^ `hh]g^ll h_ _bm #]hl^(k^lihgl^ \nko^$ Zg] ma^ k^eZm^]

]^m^kfbgZmbhg h_ ma^ @? 0+ oZen^l) D_ hger bgm^kf^]bZm^ ^__b\Z\r kZm^l Zk^ ZoZbeZ[e^' bgm^kik^mZmbhg h_ ]ZmZ pbee k^fZbg oZ`n^' pab\a pbee bg\k^Zl^ ma^ kbld h_ fblbgm^kik^mZmbhg) >hgl^jn^gmbZeer' Zm e^Zlm lhf^ ]hlZ`^l' k^lnembg` bg _nee Zg] gh Zgma^efbgmb\ ^__b\Z\r Z`Zbglm :# HXGYOROKTYOY p^k^ Zelh Z]fbgblm^k^]) <`Zbg' ^__^\ml h_ ma^ Zfbghia^greZfb]bg^l pbee [^ ]bl\nll^] bg l^\mbhg 2)3' ma^ ^__^\ml h_ ma^ \r\ehh\mZ]^ilbi^imb]^l bg l^\mbhg 2)4 Zg] ma^ ^__^\ml h_ ma^ \hf[bgZmbhgl bg l^\mbhg 2),+)

/&, 8dOZcObW]\ ]T \S[ObWQWROZ /2 9/93 STTWQOQg OUOW\ab '. 185/6

--3 1USVXKNKTYO\K JOYI[YYOUT

Oa^ h[l^koZmbhgl hg eZkoZe ]^o^ehif^gm pbmabg ma^ ahlm fhlmer Z`k^^] pbma _bg]bg`l h_ KZg^lZk Zg] >khee V/+W) Abklm eZkoZ^ ^qmkn]bg` ma^bk \Zn]Ze ^g]l bgmh ma^ enf^g h_ ma^ `nm p^k^ _hng] hg ]Zr -, V#O# a^k^ Zg] hg ]Zr -+ V#O# [r KZg^lZk Zg] >khee V/+W) Chp^o^k' KZg^lZk Zg] >khee _hng] gh ablmhmkhib\ eZkoZ^ Z_m^k ]Zr -, V#O)' pa^k^Zl bg hnk lmn]r lfZee [nm lb`gb_b\Zgm gnf[^kl h_ ablmhmkhib\ eZkoZ^ p^k^ _hng] ngmbe ]Zr -4 V#O) Dgm^k^lmbg`er' _bg]bg`l hg ma^ _^fZe^*fZe^ kZmbh' lm^Z]ber ]^o^ehibg` mhpZk]l fhk^ fZe^l Zg] fZe^ ?# S[XOY lnkobobg` ehg`^k maZg _^fZe^l V/,W p^k^ Zelh h[l^ko^] bg hnk lmn]r' pab\a bl bg fZkd^] \hgmkZlm mh hma^k iZkZlbmb\ g^fZmh]^ li^\b^l' pa^k^ _^fZe^l lnkobo^ ehg`^k maZg fZe^l V/,W) Aheehpbg` ma^ iZkZlbmheh`b\Ze \aZkZ\m^kblZmbhg' in[eb\Zmbhg / #\aZim^k 0$ Zelh bgo^lmb`Zm^] ma^ OT \O\U ihm^g\r h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' mkb[^g]bfb]bg^ Zg] ]

/&- <\dSabWUObW]\a ]\ bVS /2 9/93 ^VO`[OQ]YW\SbWQa ]T O[W\]^VS\gZO[WRW\Sa W\ `Oba

Kkh_hng] dghpe^]`^ hg ma^ iaZkfZ\heh`r h_ Zgma^efbgmb\l bl ^ll^gmbZe _hk Zg ^__^\mbo^ mk^Zmf^gm' ^li^\bZeer pa^g ^__b\Z\r Z`Zbglm ^qmkZ bgm^lmbgZe li^\b^l bl ]^lbk^] V/-W) Chp^o^k' ebm^kZmnk^ hg ma^ iaZkfZ\hdbg^mb\l h_ ma^ Zfbghia^greZfb]bg^ mkb[^g]bfb]bg^ bl ab`aer \hgmkho^klbZe) TnZg KZ GR# V/.W k^ihkm^] maZm mkb[^g]bfb]bg^ bl kZib]er f^mZ[hebl^] bgmh mph fhe^\ne^l h_ ]) Oa^k^_hk^' bg ieZlfZ lZfie^l' hger ] Zk^ ]^m^\mZ[e^ nlbg` ab`a i^k_hkfZg\^ ebjnb] \akhfZmh`kZiar _heehp^] [r fZll li^\mkhf^mkr V/.W) <]]bmbhgZeer' bm pZl k^ihkm^] maZm mkb[^g]bfb]bg^' bg ma^ Z[l^g\^ h_ Zgr ^gsrfZmb\ ikh\^ll^l' lihgmZg^hnler Zg] kZib]er ]blbgm^`kZm^l bgmh ma^ Z[ho^(f^gmbhg^] fhe^\ne^l bg Zg Zjn^hnl ^gobkhgf^gm V//W) Jg ma^ \hgmkZkr' SbZh KZ GR# V-0W lnffZkbl^] ngin[ebla^] ]ZmZ pbma i^Zd ieZlfZ \hg\^gmkZmbhgl h_ .,3 g`*fe mkb[^g]bfb]bg^ Zg] Zg

h_ ,12/ g` !a*fe Z_m^k hkZe ]hlZ`^ h_ ,0+ f`*d` mkb[^g]bfb]bg^ mh kZml) Ankma^kfhk^' ma^r k^ihkm^] maZm lfZee Zfhngml h_ mkb[^g]bfb]bg^ aZo^ Zelh [^^g ]^m^\m^] bg anfZg _Z^\^l Z_m^k hkZe bgmZd^ h_ Z mZ[e^m \hgmZbgbg` --4 1NGVZKX ,

/++ f` mkb[^g]bfb]bg^ V-0W) ?n^ mh ma^ lmkbdbg` ]b__^k^g\^l bg in[ebla^] h[l^koZmbhgl' \aZim^k / #in[eb\Zmbhg .$ Zelh k^ihkml hg OT \O\U ieZlfZ iaZkfZ\hdbg^mb\ ZgZerlbl Z_m^k hkZe mk^Zmf^gml pbma mkb[^g]bfb]bg^ Zg] ]

/&. <\dSabWUObW]\a ]\ bVS []RS ]T OQbW]\ ]T O\bVSZ[W\bWQa Pg SZSQb`]\ [WQ`]aQ]^g

Dm bl `^g^kZeer Z\\^im^]' maZm \r\ehh\mZ]^ilbi^imb]^l [hhlm ma^ bgab[bmhkr lrlm^f h_ g^fZmh]^l' pab\a k^lneml bg ari^kiheZkblZmbhg h_ \^eel Zg] _bgZeer bg]n\^l _eZ\\b] iZkZerlbl h_ ma^ phkfl V.,W) Ahk Zfbghia^greZfb]bg^l Z\mboZmbhg h_ ma^ ^q\bmZmhkr lrlm^f aZl [^^g ]^fhglmkZm^]' iZkmb\neZker [r Z\mboZmbhg h_ ]blmbg\m ln[l^ml h_ <>aMl' ]^i^g]bg` hg ma^ g^fZmh]^ li^\b^l V/0W) =hhlmbg` ma^ ^q\bmZmhkr lrlm^f k^lneml bg ]^iheZkblZmbhg h_ \^eel' _bgZeer bg]n\bg` liZlmb\ iZkZerlbl V/1W) Nbg\^ bm aZl [^^g ]^fhglmkZm^] maZm ma^ #fhlm(ebd^er$ mZk`^ml h_ [hma ]kn` \eZll^l Zk^ ^qik^ll^] bg lhfZmb\ fnl\e^ \^eel Zehg` ma^ pahe^ [h]r h_ 1# KRKMGTY Zg] Zllnfbg` maZm mabl bl Zelh ma^ \Zl^ bg :# HXGYOROKTYOY ' lmkhg` fhkiaheh`b\Ze \aZg`^l phne] [^ ^qi^\m^] _heehpbg` mk^Zmf^gm pbma <>aM Z`hgblml) Oanl in[eb\Zmbhg . #\aZim^k /$ Zelh k^ihkml bgo^lmb`Zmbhgl hg ma^ fh]^ h_ Z\mbhg h_ \r\ehh\mZ]^ilbi^imb]^l Zg] Zfbghia^greZfb]bg^l Z`Zbglm :# HXGYOROKTYOY nlbg` l\Zggbg` ^e^\mkhg fb\khl\hir) Dgm^k^lmbg`er' gh fhkiaheh`r \aZg`^l h_ :# HXGYOROKTYOY _heehpbg` mk^Zmf^gm pbma KA,+--< bg \hfiZkblhg mh ngmk^Zm^] phkfl pa^k^ h[l^ko^]' ^q\^im _hk l^o^kZe lfZee \nmb\neZk dgh[l g^qm mh ma^ ehg`bmn]bgZe kb]`^l) Chp^o^k' mabl pZl ghm ng^qi^\m^]' lbg\^ _eZ\\b] iZkZerlbl hger k^lneml bg fnl\e^ k^eZqZmbhg) Dg laZki \hgmkZlm' mk^Zmf^gml pbma ^bma^k Zfbghia^greZfb]bg^l hk e^oZfblhe^ k^lnem^] bg lb`gb_b\Zgm ^__^\ml hg ma^ mhmZe [h]r laZi^' fhk^ ik^\bl^er bg lmkhg`er \hgmkZ\m^] :# HXGYOROKTYOY ) Nbg\^ ma^ Zfbghia^greZfb]bg^l laZk^ ma^bk fh]^ h_ Z\mbhg pbma e^oZfblhe^' Zm e^Zlm bg 1# KRKMGTY V/2W' ma^ h[l^ko^] ahfh`^ghnl ia^ghmri^l p^k^ ieZnlb[e^) ?b__^k^g\^l bg ma^ bgm^glbmr h_ \hgmkZ\mbhgl fb`am [^ ]n^ mh ]b__^k^gm bgmkbglb\ ]kn` \hg\^gmkZmbhgl hk Z\mboZmbhg h_ ]b__^k^gm ln[l^ml h_ <>aMl) Oabl fb`am Zelh [^ ma^ ^qieZgZmbhg _hk ^qmknlbhg h_ ma^ mph mpblm^] lib\ne^l hger _heehpbg` mkb[^g]bfb]bg^ mk^Zmf^gm) Nbg\^ \hf[bgZmbhgl aZ] gh _nkma^k ^__^\ml hg ma^ fhkiaheh`r h_ :# HXGYOROKTYOY bg \hfiZkblhg mh ma^ ^__^\ml h_ ma^ lbg`e^ ]kn`l Zehg^' bgm^kik^mZmbhg h_ ]ZmZ h[mZbg^] obZ l\Zggbg` ^e^\mkhg fb\khl\hir pbee ghm [^ bg\en]^] bg ma^ ]bl\nllbhg h_ ]kn` \hf[bgZmbhgl bg l^\mbhg 2),+) -.+ 1USVXKNKTYO\K JOYI[YYOUT

/&/ <\dSabWUObW]\a ]\ bVS []RS ]T OQbW]\ ]T QgQZ]]QbORS^aW^S^bWRSa Pg VSbS`]Z]U]ca Sf^`SaaW]\ ]T ^]bS\bWOZ bO`USb US\Sa W\ (. 0),9/6 ]]QgbSa

Oa^ fh]^ h_ Z\mbhg h_ ma^ \r\ehh\mZ]^ilbi^imb]^l bl Zllh\bZm^] pbma mak^^ ihm^gmbZe mZk`^ml' bg\en]bg` B<=< < k^\^imhkl V/3'/4W' ma^ eZmkhiabebg ebd^ B ikhm^bg \hnie^] k^\^imhk GaMl' pab\a Zelh k^jnbk^ mak^^ ZnqbebZkr ikhm^bgl pbma \aZi^khg^ _ng\mbhg _hk ln\\^ll_ne ^qik^llbhg V/0W) <]]bmbhgZeer' hh\rm^l Zk^ , ff bg ]bZf^m^k Zg] \Zg [^ \hgo^gb^gmer bgc^\m^] pbma \MI< Zg] ^Zlber i^k_nl^] pbma f^]bZ hk ]kn`l h_ \ahb\^) Chp^o^k' ma^ lbs^ h_ ma^ hh\rm^ Zelh \Znl^] Z fZchk ]blZ]oZgmZ`^ [r bgo^lmb`Zmbg` ma^ iarlbheh`b\Ze ikhi^kmb^l h_ NGJ(,) NGJ(, \aZgg^el aZo^ [^^g lahpg mh k^jnbk^ ]^iheZkblZmbhg h_ ma^ f^f[kZg^ mh Zm e^Zlm &+ fQ bg \hf[bgZmbhg pbma ab`a' mkZglb^gm bg\k^Zl^ h_ bgmkZ\^eeneZk \Ze\bnf mh hi^g V1,W) Nbg\^ gh \aZg`^l bg \nkk^gml bg NGJ(, bgc^\m^] hh\rm^l bg \hfiZkblhg mh pZm^k bgc^\m^] hh\rm^l p^k^ h[l^ko^]' ma^ k^jnbk^] \Ze\bnf \hg\^gmkZmbhgl p^k^ h[obhnler ghm Z\ab^o^]' ik^lnfZ[er ]n^ mh ma^ \hfiZkZmbo^er ^ghkfhnl ohenf^ h_ ma^ hh\rm^l) @o^g ik^bg\n[Zmbhg h_ ma^ hh\rm^l pbma Z \Ze\bnf bhghiahk^ bg \Ze\bnf(_k^^ f^]bnf' _heehp^] [r ma^ i^k_nlbhg pbma ab`a \Ze\bnf \hg\^gmkZmbhgl ]b] ghm k^lnem bg Zgr bg\k^Zl^] \nkk^gml) Chp^o^k' ^fh]^ilb]^ ng^jnboh\Zeer bg]n\^] Z lb`gb_b\Zgm bg\k^Zl^] \nkk^gm bg NGJ(, bgc^\m^] hh\rm^l' ]^fhglmkZmbg` ]bk^\m Z\mboZmbhg h_ ma^ NGJ(, \aZgg^e [r \r\ehh\mZ]^ilbi^imb]^l' pab\a pbee [^ _nkma^k ]bl\nll^] bg l^\mbhg 2)4)

-., 1NGVZKX ,

/&0 8dOZcObW]\ ]T O[W\]^VS\gZO[WRW\Sa Oa P`]OR%a^SQb`c[ O\bVSZ[W\bWQa

Oa^ OT \OZXU Zg] OT \O\U ^__b\Z\b^l h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' ]hfiZkbg` ma^ ^__b\Z\r h_ ma^ Zfbghia^greZfb]bg^l bg ma^ OT \OZXU ZllZrl Z`Zbglm g^fZmh]^l' Zfb]Zgm^e lahp^] hger fbgbfZe hk Zm [^lm iZkmbZe k^]n\mbhg h_ g^fZmh]^ Z\mbobmr ^o^g Zm ab`a

\hg\^gmkZmbhgl k^lnembg` bg @> 0+ oZen^l h_ 11)4 iif Zg] ,/,)0 iif Z`Zbglm :# HXGYOROKTYOY Z]neml Zg] G.' k^li^\mbo^er) Oa^ ^__b\Z\r Z`Zbglm G, h_ ?# YVOXGROY pZl ^o^g lh ehp' maZm Z

\Ze\neZmbhg h_ Zg @> 0+ oZen^ pZl ghm ihllb[e^) Chp^o^k' ma^l^ k^lneml Zk^ ghm lnkikblbg`' lbg\^ Zfb]Zgm^e bl \hglb]^k^] mh Z\m Zl Z ikh]kn`' [^bg` kZib]er f^mZ[hebl^] mh ma^ Zgma^efbgmb\Zeer Z\mbo^ ] 0+ oZen^l h_ ,), iif Zg] .)2 iif Z`Zbglm Z]nem :# HXGYOROKTYOY ' h_ +)+1 iif Zg] +)- iif Z`Zbglm :# HXGYOROKTYOY G. Zg] h_ +)3 iif Zg] ,)- iif Z`Zbglm ?# YVOXGROY G,' k^li^\mbo^er) Oa^

\hglmZgmer ehp^k @> 0+ oZen^l _hk ] 0+ oZen^l _hk mkb[^g]bfb]bg^ \Zg [^ ^qieZbg^] [r ma^ _Z\m' maZm mkb[^g]bfb]bg^ kZib]er ]blbgm^`kZm^l bgmh mph fhe^\ne^l ]) Nbg\^ g^bma^k OK lahp^] Zgr Zgma^efbgmb\ ^__b\Z\r Z`Zbglm g^fZmh]^l Zg] mk^fZmh]^l V//'1.W

-.- 1USVXKNKTYO\K JOYI[YYOUT

Zg] ] ^q^km \^lmh]b\b]Ze ^__^\ml hk' fhk^ ebd^er' mkb[^g]bfb]bg^ ghm \hfie^m^er ]blbgm^`kZm^l bgmh ]k^fhiahk @G*]^bhgbl^] pZm^k$' f^Zgbg` maZm mkb[^g]bfb]bg^ \Zg [^ lnli^\m^] mh ]b__nl^ hger lehper bgmh ma^ Zjn^hnl ^gobkhgf^gm) Oabl Z`Zbg \hkk^lihg]l mh h[l^koZmbhgl' pa^k^ lfZee Zfhngml h_ mkb[^g]bfb]bg^ aZo^ [^^g ]^m^\m^] bg anfZg _Z^\^l Z_m^k hkZe bgmZd^ h_ Z mZ[e^m \hgmZbgbg` /++ f` mkb[^g]bfb]bg^ V-0W) Chp^o^k' mabl phne] bfieb\Zm^ maZm mkb[^g]bfb]bg^ bl ghm hger Z ikh]kn`' [nm ^q^kml Zgma^efbgmb\' Zm e^Zlm \^lmh]b\b]Ze' ^__b\Z\r bml^e_) Oa^k^_hk^' OT \OZXU ^qi^kbf^gml nlbg` ]

Z`Zbglm :# HXGYOROKTYOY nlbg` Z lbg`e^(mk^Zmf^gm k^`bf^g p^k^ ^oZenZm^]' k^lnembg` bg @? 4+ oZen^l h_ 0),+/ f`*d` Zg] 3)/.0 f`*d` k^li^\mbo^er V//W) Dgm^k^lmbg`er' ma^ ihm^g\b^l h_ ]k^fhiahk @G*]^bhgbl^] pZm^k fb`am Zelh \Znl^ Z lehp^k k^e^Zl^ h_ ma^ eZk`^k mkb[^g]bfb]bg^ fhe^\ne^l bg \hfiZkblhg mh ma^ lfZee^k ]

-.. 1NGVZKX ,

Z in[eb\Zmbhg' pa^k^ Zfb]Zgm^e pZl Zelh _hng] mh [^ hger fh]^kZm^er Z\mbo^ Z`Zbglm ?# S[XOY V-/W) Oa^k^_hk^' Zfb]Zgm^e pZl ghm _nkma^k ^oZenZm^] nlbg` ]b__^k^gm khnm^l h_ Z]fbgblmkZmbhg) Dg laZki \hgmkZlm' \hfie^m^ ^ebfbgZmbhgl h_ ma^ phkf [nk]^g' pZl h[l^ko^] pa^g mk^Zmbg` iZm^gm ?# S[XOY bg_^\mbhgl pbma mak^^ \hgl^\nmbo^ hkZe ]hl^l h_ ^bma^k -0 f`*d` mkb[^g]bfb]bg^ hk ,++ f`*d` ]aMl V/2W) Oa^l^ _bg]bg`l p^k^ bg ebg^ pbma ma^ h[l^ko^] fhkiaheh`b\Ze \aZg`^l h_ :# HXGYOROKTYOY mk^Zm^] pbma ]aMl' k^lnembg` bg liZlmb\ iZkZerlbl) Dg _Z\m' b_ Zfbghia^greZfb]bg^l laZk^ ma^bk fh]^ h_ Z\mbhg pbma e^oZfblhe^' ma^ oZen^ h_ ma^l^ ]kn`l _hk ma^ ihm^gmbZe nl^ bg anfZgl Zg] ebo^lmh\d bl o^kr ehp' lbg\^ ma^r phne] ghm aZo^ k^lblmZg\^([k^Zdbg` ikhi^kmb^l) Chp^o^k' l^o^kZe k^\^gmer in[ebla^] ]ZmZ lahp ln[lmZgmbZe ]b__^k^g\^l k^`Zk]bg` ma^ \hfihlbmbhgl h_ <>aMl Zg] ma^bk l^glbmbobmr mh Zgma^efbgmb\l pa^g \hfiZkbg` ]b__^k^gm g^fZmh]^ li^\b^l) Dg ma^ [h]r fnl\e^ h_ ;# JKTZGZ[S _hnk ln[mri^l h_ <>aMl pbma ]blmbg\m iaZkfZ\heh`b\Ze

-./ 1USVXKNKTYO\K JOYI[YYOUT ikhi^kmb^l aZo^ [^^g b]^gmb_b^] nlbg` ^e^\mkhiarlbheh`r V/0W) Oa^ ehll h_ ln[mri^ B .0 iN pZl lahpg mh [^ Zllh\bZm^] pbma e^oZfblhe^ k^lblmZg\^ V/0W) =r a^m^kheh`hnl ^qik^llbhg h_ ]b__^k^gm \hf[bgZmbhgl h_ <>aM ln[ngbml bg C# RGK\OY hh\rm^l' ma^ _hnk iaZkfZ\heh`b\Zeer ]b__^k^gm mri^l h_ <>aMl p^k^ k^\hglmbmnm^]' pab\a Zee lahp^] ^__^\ml bg ma^ ik^l^g\^ h_ mkb[^g]bfb]bg^ [nm ghm bg ma^ ik^l^g\^ h_ e^oZfblhe^ bg]b\Zmbg` maZm mkb[^g]bfb]bg^ fZr lmbee [^ ^__^\mbo^ bg e^oZfblhe^ k^lblmZgm phkfl V/0W) Oh lnffZkbl^ ma^ _nkma^k ihm^gmbZe h_ ma^ Zfbghia^greZfb]bg^l Zl [khZ](li^\mknf Zgma^efbgmb\l bg o^m^kbgZkr f^]b\bg^ Zg] _hk ma^ Z]fbllbhg hg ma^ RCJ eblm h_ ^ll^gmbZe f^]b\bg^l _heehpbg` hkZe Z]fbgblmkZmbhg \hglmZgmer ehp^k ]hlZ`^l h_ mkb[^g]bfb]bg^ p^k^ k^jnbk^] bg \hfiZkblhg mh ]aMl ln[mri^l V/0W' \Zg Zelh [^ \hg_bkf^] bg hma^k g^fZmh]^ li^\b^l' Zfbghia^greZfb]bg^l fb`am [^ h_ fZchk bgm^k^lm _hk _nkma^k ^oZenZmbhg Zl [khZ](li^\mknf Zgma^efbgmb\l) Chp^o^k' lbg\^ ^o^g bg fnembie^ mk^Zmf^gm k^`bf^gl k^eZmbo^er ab`a ]hlZ`^l p^k^ k^jnbk^] mh \nk^ bg_^\mbhgl' Z lbg`e^ ]hl^ k^`bf^g pbma mkb[^g]bfb]bg^ Zii^Zkl mh [^ ngk^Zeblmb\) Hnembie^ ]hl^ k^`bf^gl Zk^ bg ebg^ pbma Nm^bgfZgg KZ GR# V-1W' ln``^lmbg` ma^ ^oZenZmbhg h_ ma^ ^__b\Z\r h_ fnembie^(]hl^ mk^Zmf^gml pbma mkb[^g]bfb]bg^ mh \nk^ anfZg bgm^lmbgZe mZ^gbhlbl Zg] bg_^\mbhgl pbma ># YZKXIUXGROY Zemahn`a bm fnlm [^ mZd^g bgmh Z\\hngm maZm mabl phne] h_ \hnkl^ lb`gb_b\Zgmer bg\k^Zl^ \hlml Zg] fZgZ`^f^gm ^__hkml bg ma^ \hgm^qm h_ H?

-.0 1NGVZKX ,

/&1 8dOZcObW]\ ]T QgQZ]]QbORS^aW^S^bWRSa Oa SfbS\RSR P`]OR%a^SQb`c[ O\bVSZ[W\bWQa

Oa^ OT \OZXU Zg] OT \O\U ^__b\Z\b^l h_ ma^ \r\ehh\mZ]^ilbi^imb]^l ^fh]^ilb]^ Zg] KA,+--< Z`Zbglm ma^ ]b__^k^gm m^lm^] g^fZmh]^ li^\b^l Zg] eb_^ \r\e^ lmZ`^l p^k^ ab`aer ahfh`^ghnl' pbma ^fh]^ilb]^ \hglmZgmer lahpbg` ab`a^k ^__b\Z\r bg \hfiZkblhg mh KA,+--<) Chp^o^k' ]^i^g]bg` hg ma^ khnm^ h_ Z]fbgblmkZmbhg' ma^ ]b__^k^g\^l [^mp^^g ma^ mph p^k^ oZkbZ[er ikhghng\^]) @fh]^ilb]^ Zg] KA,+--< lahp^] o^kr ab`a \hg\^gmkZmbhg(]^i^g]^gm Zgma^efbgmb\ ihm^g\r bg ma^ mak^^ OT \OZXU ZllZrl) Oa^ @> 0+ oZen^l p^k^ ]^m^kfbg^] Zm +)+1 iif Zg] +)+2 iif Z`Zbglm Z]nem :# HXGYOROKTYOY ' Zm +)+1 iif Zg] +),0 iif Z`Zbglm :# HXGYOROKTYOY G. Zg] Zm +)+. iif Zg] +)+1 iif Z`Zbglm ?# YVOXGROY G, _hk ^fh]^ilb]^ Zg] KA,+--<' k^li^\mbo^er) Oa^ ab`a OT \OZXU ihm^g\r h_ [hma \hfihng]l pZl Zelh ik^obhnler h[l^ko^] bg Zg OT \OZXU fhmbebmr ZllZr mZk`^mbg` Z]nem 6# IUTZUXZ[Y V11W) ?^libm^ lb`gb_b\Zgmer ab`a^k ^__b\Z\r h_ ^fh]^ilb]^ bg [hma fhmbebmr ZllZrl Zg] h[l^koZmbhgl' pa^k^ Z /+(_he] ab`a^k lbg`e^ hkZe ]hlZ`^ h_ KA,+--< #,++ f`*d`$ bg \hfiZkblhg mh ^fh]^ilb]^ #-)0 f`*d`$ pZl k^jnbk^] mh \nk^ :# HXGYOROKTYOY bg_^\mbhgl bg kZml V12'13W' bm pZl ]^\b]^] mh _nkma^k ^oZenZm^ ma^ OT \O\U ^__b\Z\r h_ KA,+--< Z`Zbglm :# HXGYOROKTYOY bg kZml bg fhk^ ]^mZbe) Oak^^ mk^Zmf^gml pbma

KA,+--< lahp^] Z ab`a ^__b\Z\r Z`Zbglm :# HXGYOROKTYOY ' beenlmkZm^] [r Zg @? 0+ oZen^ h_ ,)- f`*d` Zg] [r \hfie^m^ ^ebfbgZmbhg h_ phkf [nk]^gl Zm -)0 f`*d`) Oa^l^ k^lneml Z`k^^ pbma Z ik^obhnl lmn]r' pa^k^ . ! -)0 f`*d` KA,+--< k^lnem^] bg Zg Zefhlm \hfie^m^ ^ebfbgZmbhg h_ :# HXGYOROKTYOY V14W) Oa^ lmkbdbg` ]b__^k^g\^ mh ma^ lmn]r pa^k^ ,++ f`*d` KA,+--< p^k^ k^jnbk^] V11W k^fZbgl ngdghpg) Chp^o^k' >hg]^k KZ GR# V11W m^lm^] hger Z lbg`e^ ]hl^ h_ KA,+--< bglm^Z] h_ mak^^ \hgl^\nmbo^ ]hlZ`^l Zg] ihm^gmbZeer Z fbqmnk^ h_ KA,+-- blhf^kl pZl nl^]' pab\a k^lneml bg Z lb`gb_b\Zgm k^]n\mbhg h_ ma^ Zgma^efbgmb\ ^__b\Z\r) Oanl' ma^ ^__b\Z\r h_ KA,+--< Z`Zbglm :# HXGYOROKTYOY Zii^Zkl mh [^ bg ma^ lZf^ ]hl^ kZg`^ Zl ^fh]^ilb]^ #, ! -)0 f`*d`$ V13W) Ihm m^lmbg` ^fh]^ilb]^ Z`Zbglm :# HXGYOROKTYOY bg ma^ lZf^ mk^Zmf^gm k^`bf^g \Zg [^ l^^g Zl Z p^Zd ihbgm h_ ma^ lmn]r' [nm ]n^ mh ma^ ikbg\bie^ h_ ma^ mak^^ Ml Ö k^]n\mbhg' k^_bg^f^gm Zg k^ieZ\^f^gm h_ ZgbfZe m^lmbg`l Ö bm pZl ]^\b]^] mh pZbo^ _nkma^k m^lmbg` h_ ^fh]^ilb]^ Z`Zbglm :# HXGYOROKTYOY Zg] i^k_hkf bgo^lmb`Zmbhgl hg ma^ fhkiaheh`r h_ phkfl Z_m^k mk^Zmf^gm pbma KA,+--< [r l\Zggbg` ^e^\mkhg fb\khl\hir bglm^Z]) Chp^o^k' ma^ fhkiaheh`r h_ :# HXGYOROKTYOY Z_m^k KA,+--< mk^Zmf^gml pZl eZk`^er ng\aZg`^]' ^q\^im _hk l^o^kZe lfZee \nmb\neZk dgh[l g^qm mh ma^ ehg`bmn]bgZe kb]`^l #\Znl^ k^fZbgl ngdghpg$) Nbg\^ KA,+--< bl dghpg mh \Znl^ _eZ\\b] iZkZerlbl' bm pZl ghm ng^qi^\m^] mh _bg] hger fbgbfZe \aZg`^l _heehpbg` KA,+--< mk^Zmf^gm)

-.1 1USVXKNKTYO\K JOYI[YYOUT

Oa^ hnm\hf^ h_ ma^ \hfiZkblhg h_ ma^ OT \O\U ^__b\Z\r h_ ^fh]^ilb]^ Zg] KA,+--< Z`Zbglm iZm^gm ?# S[XOY bg_^\mbhgl pZl lhf^paZm ng^qi^\m^]) Oak^^ ]hlZ`^l h_ ,+ f`*d`' -0 f`*d` Zg] 0+ f`*d` ^fh]^ilb]^ hk 0+ f`*d`' -++ f`*d` Zg] /++ f`*d` KA,+--< nlbg` Zg hkZe' bgmkZi^kbmhg^Ze Zg] ln[\nmZg^hnl khnm^ h_ Z]fbgblmkZmbhg p^k^ k^jnbk^] mh Z\ab^o^ ^ebfbgZmbhgl h_ ?# S[XOY #944 $) Ra^k^Zl ma^ ]b__^k^g\^l [^mp^^g ^fh]^ilb]^ Zg] KA,+--< nlbg` bgmkZi^kbmhg^Ze hk ln[\nmZg^hnl Z]fbgblmkZmbhgl p^k^ ab`aer lb`gb_b\Zgm' gh lb`gb_b\Zgm ]b__^k^g\^ [^mp^^g ma^ mph ]kn`l pZl h[l^ko^] pa^g \hfiZkbg` ma^ ^__b\Z\r _heehpbg` hkZe mk^Zmf^gml) Oabl bl ]^fhglmkZm^] [r ma^ @? 4+ oZen^l -/)0 f`*d` Zg] .1)0 f`*d` _hk ^fh]^ilb]^ Zg] KA,+--<' k^li^\mbo^er) Ahk lnbmZ[bebmr bg H?< \ZfiZb`gl Zg] _hk ma^ mk^Zmf^gm Z`Zbglm a^efbgmahlbl h_ ebo^lmh\d' ]kn`l g^^] mh aZo^ ehp ikh]n\mbhg \hlml) Dm aZl [^^g k^ihkm^]' maZm ikh]n\mbhg \hlml _hk KA,+--< Zk^ fn\a ehp^k bg \hfiZkblhg mh ^fh]^ilb]^' lbg\^ gh lrgma^mb\ ]^kboZmblZmbhg bl k^jnbk^] V2+W) Ankma^kfhk^' hkZe _hkfneZmbhg bl ma^ `he] lmZg]Zk] _hk Zee Zgma^efbgmb\l nl^] Z`Zbglm anfZg a^efbgmahlbl V2,W) Rbma k^li^\m mh ma^ ehp^k \hlml Zg] ma^ k^eZmbo^er lfZee ]b__^k^g\^l bg hkZe ^__b\Z\r' KA,+--< Zg] ghm ^fh]^ilb]^ pZl _nkma^k ^oZenZm^] Z`Zbglm ?# S[XOY ) Dg ma^ mkbie^ ]hl^ k^`bf^g' KA,+--< pZl Z[e^ mh \hfie^m^er ^ebfbgZm^ Zee ]^o^ehif^gmZe lmZ`^l h_ ?# S[XOY ) Chp^o^k' ma^ k^jnbk^] ]hlZ`^l bgo^kl^er \hkk^eZm^] pbma ma^ mbf^ liZg Z_m^k bg_^\mbhg) Oanl' ablmhmkhib\ G,' ablmhmkhib\ G-' _nkma^k ]^o^ehi^] eZkoZ^ Zg] Z]neml aZ] mh [^ mk^Zm^] pbma ,++ f`*d`' ,++ f`*d`' 0+ f`*d` Zg] 0+ f`*d` KA,+--< mh \hfie^m^er \nk^ ma^ bg_^\mbhgl' k^li^\mbo^er) Dg lbg`e^ Z]fbgblmkZmbhgl h_ KA,+--< [^mp^^g ,++ f`*d` Zg] 0++ f`*d` p^k^ k^jnbk^] mh Z\ab^o^ \hfie^m^ ^ebfbgZmbhg) Chp^o^k' G, p^k^ ghm ^o^g lb`gb_b\Zgmer k^]n\^] _heehpbg` mk^Zmf^gm pbma 0++ f`*d` KA,+--<) Oabl \Zg [^ ^qieZbg^] [r ma^ eh\ZeblZmbhg h_ ma^ eZkoZ^) <_m^k bgoZlbhg h_ ma^ bgm^lmbgZe ^ibma^ebnf' eZkoZ^ Zk^ _hng] bg ma^ [ZlZe iZkml h_ ma^ \kriml h_ Gb^[^kd{ag [^_hk^ fb`kZmbg` \ehl^k mh ma^ lnk_Z\^ h_ ma^ ^ibma^ebnf' _heehp^] [r ma^ ^qmkn]bg` ma^bk \Zn]Ze ^g]l bgmh ma^ enf^g h_ ma^ \Z^\nf' pa^k^ fhlm ebd^er ab`a^k ]kn` \hg\^gmkZmbhgl Zk^ ik^l^gm V/+W) Jg^ fb`am mabgd maZm ma^l^ ab`a ]hlZ`^l h_ KA,+--< \hne] ik^o^gm bml _nkma^k ]^o^ehif^gm Zl mkb\ankb\b]Ze ]kn`) Chp^o^k' _nkma^k lb`gb_b\Zgm bfikho^f^gm h_ ma^ ^__b\Z\r [r himbfblZmbhg h_ ma^ _hkfneZmbhg \Zg fhlm ebd^er [^ Z\ab^o^]) Oa^ lmkhg` bg_en^g\^ h_ ma^ _hkfneZmbhg bl lahpg [r ma^ ^__b\Z\r h_ ^fh]^ilb]^ Z`Zbglm ?# \[RVOY nlbg` ma^ Kkh_^g]^k Ä mZ[e^m) < lbg`e^ ]hl^ h_ , f`*d` ^fh]^ilb]^ k^lnem^] bg Zefhlm \hfie^m^ ^ebfbgZmbhg h_ bffZmnk^ Zg] fZmnk^ lmZ`^l h_ ?# \[RVOY bg ]h`l #944 $ V2-W) NbfbeZk h[l^koZmbhgl aZo^ [^^g fZ]^ [r H^aeahkg KZ GR# V2.W' ]^fhglmkZmbg` maZm Z lbg`e^ ]hl^ h_ 2),1 f`*d` ^fh]^ilb]^ #Kkh_^g]^k Ä lihm hg

-.2 1NGVZKX ,

_hkfneZmbhg _hk \Zml$ pZl ln__b\b^gm mh \e^Zk ?# S[XOY bg_^\mbhgl h_ fb\^) Dg laZki \hgmkZlm' .! 20 f`*d` ^fh]^ilb]^ nlbg` Z >k^fhiahk @G*pZm^k _hkfneZmbhg p^k^ k^jnbk^]) Oa^ fhk^ maZg ,+(_he] bg\k^Zl^ \hfiZkbg` mak^^ ]hl^l h_ Z >k^fhiahk*pZm^k _hkfneZmbhg Zg] Z lbg`e^ ]hl^ h_ ma^ himbfbl^] Kkh_^g]^k Ä _hkfneZmbhg ^fiaZlbl^l maZm ]kZfZmb\ ]^\k^Zl^l bg k^jnbk^] ]kn` ]hlZ`^l Zk^ ihllb[e^ pa^g nlbg` Zg himbfbl^] _hkfneZmbhg) =^lb]^l ma^ ^__b\Z\r ^oZenZmbhg' ma^ fh]^ h_ Z\mbhg h_ ma^ \r\ehh\mZ]^ilbi^imb]^l pZl _nkma^k bgo^lmb`Zm^]) aM ln[ngbml' Zllh\bZm^] pbma \ahebg^k`b\ ]kn` k^lblmZg\^ V2/W) akhfZ]hk^Z) 1# KRKMGTY Zg] ?# S[XOY NGJ(, p^k^ ^qik^ll^] bg C# RGK\OY hh\rm^l Zg] ZgZerl^] nlbg` ohemZ`^ \eZfi ^qi^kbf^gml) Nbg\^ NGJ(, k^jnbk^l ]^iheZkblZmbhg h_ ma^ f^f[kZg^ Zg] ab`a' mkZglb^gm bg\k^Zl^ h_ bgmkZ\^eeneZk \Ze\bnf bhgl mh hi^g V1,W' gh \hgmkhe pZl ZoZbeZ[e^ mh ]^fhglmkZm^ _ng\mbhgZe ^qik^llbhg h_ NGJ(, bg ma^ f^f[kZg^ ng]^k iarlbheh`b\Ze \hg]bmbhgl) Ra^k^Zl ohemZ`^ lm^il Z\ab^o^] ]^iheZkblZmbhg h_ ma^ f^f[kZg^'

-.3 1USVXKNKTYO\K JOYI[YYOUT

\Ze\bnf \hg\^gmkZmbhgl \hne] ghm [^ bg\k^Zl^] bg Z ln__b\b^gm fZgg^k mh h[l^ko^ \nkk^gml obZ NGJ(,) Ihm ^o^g ik^bg\n[Zmbhg h_ ma^ hh\rm^l pbma ma^ \Ze\bnf bhghiahk^ <-.,32 bg \Ze\bnf(_k^^ f^]bnf' _heehp^] [r ma^ i^k_nlbhg pbma ab`a \Ze\bnf \hg\^gmkZmbhgl ]b] k^lnem bg Zgr bg\k^Zl^] \nkk^gml) Chp^o^k' bg\n[Zmbhg h_ 1# KRKMGTY ' [nm ghm ?# S[XOY! NGJ(, bgc^\m^] hh\rm^l lahp^] lb`gb_b\Zgmer bg\k^Zl^] \nkk^gml bg ma^ ik^l^g\^ h_ ,(,+ H ^fh]^ilb]^ ho^k Z pb]^ kZg`^ h_ ahe]bg` ihm^gmbZel) Nbg\^ ma^l^ h[l^koZmbhgl p^k^ bg ma^ Z[l^g\^ h_ ab`a \Ze\bnf' ^fh]^ilb]^ ik^lnfZ[er hi^gl NGJ(, bg Z \Ze\bnf bg]^i^g]^gm fZgg^k) Ankma^kfhk^' lb`gb_b\Zgmer bg\k^Zl^] \nkk^gml p^k^ Zelh h[l^ko^] Zm ab`aer g^`Zmbo^ ihm^gmbZel bg]b\Zmbg` maZm ^fh]^ilb]^ hi^gl NGJ(, Zelh ohemZ`^(bg]^i^g]^gmer) Dgo^lmb`Zmbhgl hg ma^ k^o^klb[bebmr h_ ma^ ^fh]^ilb]^(bg]n\^] ^__^\ml lahp^] maZm ^o^g Z_m^k Z pZlahnm h_ ni mh -0 fbg \nkk^gml k^fZbg^] ng\aZg`^]) Oabl bg]b\Zm^l maZm ^fh]^ilb]^ \Znl^l obkmnZeer bkk^o^klb[e^ ^__^\ml' fhlm ebd^er lbg\^ ^fh]^ilb]^ k^fZbgl bg ma^ f^f[kZg^ ]n^ mh bml ar]khiah[b\ lmkn\mnk^ Zg] bl ma^k^_hk^ ghm pZlaZ[e^) Chp^o^k' ik^bg\n[Zmbhg pbma ma^ NGJ(, [eh\d^k o^kkn\neh`^g ik^o^gm^] ^fh]^ilb]^ bg]n\^] \nkk^gml' pa^k^Zl bg\n[Zmbhg pbma o^kkn\neh`^g _heehpbg` Z\mboZmbhg [r ^fh]^ilb]^ aZ] gh bg_en^g\^) Oabl ln``^lml maZm [hma ]kn`l [bg] o^kr mb`amer mh NGJ(, Zg] \Zgghm k^ieZ\^ ^Z\a hma^k hg\^ ma^ hma^k hg^ aZl [hng]) C^k^ bm pZl lahpg _hk ma^ _bklm mbf^ maZm ^fh]^ilb]^ ]bk^\mer hi^gl NGJ(,' pab\a lb`gb_b\Zgmer bfikho^l ma^ ng]^klmZg]bg` h_ ma^ fh]^ h_ Z\mbhg h_ ma^ \r\ehh\mZ]^ilbi^imb]^l) Chp^o^k' l^o^kZe jn^lmbhgl k^fZbg hi^g) Oa^ lmn]r b]^gmb_b^] l^o^kZe lieb\^ oZkbZgml Zg] ^o^g iZkZeh`l bg iZkZlbmb\ g^fZmh]^l ln``^lmbg` maZm ma^k^ Zk^ ln[lmZgmbZe ]b__^k^g\^l bg \aZgg^e ikhi^kmb^l [^mp^^g g^fZmh]^ li^\b^l) Dg hk]^k mh bgo^lmb`Zm^ ma^ ]b__^k^g\^l Zg] lbfbeZkbmb^l h_ ma^ ]b__^k^gm hkmaheh`l' bg\en]bg` l^glbmbobmr mh ^fh]^ilb]^' ma^r aZo^ mh [^ a^m^kheh`hnler ^qik^ll^] Zg] \aZkZ\m^kbl^] nlbg` ^e^\mkhiarlbheh`b\Ze f^mah]l) Ankma^kfhk^' bm aZl g^o^k [^^g lahpg maZm ]b__^k^gm lieb\^ _hkfl Zk^ Z[e^ mh _hkf a^m^khf^kb\ NGJ(, \aZgg^el Zg] ^o^g fhk^ bfihkmZgmer' ma^ bg_en^g\^ h_ ma^ h[l^ko^] mkng\Zm^] _hkf h_ ?# S[XOY lahne] [^ bgo^lmb`Zm^] bg ]^mZbe' mh Z]]k^ll ma^ _heehpbg` jn^lmbhgl #b$ ]h ma^ mkng\Zm^] _hkfl [nbe] ahfhf^kb\ \aZgg^el' #bb$ b_ ma^ mkng\Zm^] _hkfl [nbe] ahfhf^kb\ \aZgg^el' Zk^ ma^l^ \aZgg^el l^glbmbo^ mh ^fh]^ilb]^' #bbb$ ]h ma^ mkng\Zm^] _hkfl iZkmb\biZm^ bg a^m^khf^kb\ \aZgg^el #bo$ b_ ma^ mkng\Zm^] _hkfl iZkmb\biZm^ bg a^m^khf^kb\ \aZgg^el' Zk^ ma^l^ \aZgg^el l^glbmbo^ mh ^fh]^ilb]^ Zg] _bgZeer #o$ ]h ma^ mkng\Zm^] _hkfl aZo^ ]hfbgZgm g^`Zmbo^ ^__^\ml: Chp^o^k' Zl ehg` Zl \aZgg^el \Zg [^ ^qik^ll^] Zg] hi^g^] [r ^fh]^ilb]^' ma^ C# RGK\OY hh\rm^ fh]^e bl lnbmZ[e^' [nm lbg\^ ma^ bgmkZ\^eeneZk \Ze\bnf \hg\^gmkZmbhg \Zgghm [^ \hgmkhee^] ZiikhikbZm^er gh iarlbheh`b\Ze ZgZerlbl h_ \aZgg^e _ng\mbhg bl ihllb[e^) Oa^k^_hk^' ^qik^llbhg h_ NGJ(, bg lfZee^k \^eel' ln\a Zl C@F-4. \^eel' phne] bfikho^ ma^ lbmnZmbhg lb`gb_b\Zgmer)

-.4 1NGVZKX ,

/&)( 8dOZcObW]\ ]T R`cU Q][PW\ObW]\a Oa P`]OR%a^SQb`c[ O\bVSZ[W\bWQa

Oph mri^l h_ ]kn` \hf[bgZmbhgl p^k^ m^lm^] pbmabg ma^ lmn]b^l5 Abklm' Z \hf[bgZmbhg h_ mph \ahebg^k`b\ ]kn`l #mkb[^g]bfb]bg^ Zg] e^oZfblhe^$ pZl ^oZenZm^] Z`Zbglm 6# SOIXUYZUSG OT \O\U ' ?# YVOXGROY G, OT \OZXU ' :# HXGYOROKTYOY G. Zg] Z]neml OT \OZXU Zg] :# HXGYOROKTYOY OT \O\U ) N^\hg]er' Z \ahebg^k`b\ ]kn` #]aMl maZm Zk^ l^glbmbo^ mh mkb[^g]bfb]bg^ [nm ghm mh e^oZfblhe^' #bb$ ihhk nimZd^ h_ e^oZfblhe^ [r \^lmh]^l hk #bbb$ Z \hfie^m^er ]b__^k^gm fh]^ h_ Z\mbhg h_ mkb[^g]bfb]bg^ bg \^lmh]^l maZg bg g^fZmh]^l) Chp^o^k' lbg\^ irkZgm^e bl dghpg mh [^ Z\mbo^ Z`Zbglm ma^ ^jnbg^ \^lmh]^l /TUVRUIKVNGRG lii) V3+'3,W' \hf[bgZmbhgl h_ mkb[^g]bfb]bg^ pbma irkZgm^e lahne] [^ ^oZenZm^] bg _nmnk^ ^qi^kbf^gml) Oa^ ]bo^kl^ ^__^\ml h_ \ahebg^k`b\ ]kn`l Zk^ Z`Zbg bg Z`k^^f^gm pbma k^\^gm _bg]bg`l [r =nqmhg KZ GR# V/0W' lahpbg` maZm mkb[^g]bfb]bg^ Zg] irkZgm^e Zk^ Z`hgblml h_ ]blmbg\m <>aM ln[mri^l h_ ;# JKTZGZ[S ' pab\a Zk^ bgl^glbmbo^ mh e^oZfblhe^) Dg ma^ OT \OZXU ZllZrl Z`Zbglm g^fZmh]^l' e^oZfblhe^ \hglmZgmer lahp^] ]hl^(]^i^g]^gm

^__^\ml' k^lnembg` bg @> 0+ oZen^l h_ -)- iif' +)- iif Zg] -), iif Z`Zbglm G, h_ ?# YVOXGROY Zl p^ee Zl Z`Zbglm Z]neml Zg] G. h_ :# HXGYOROKTYOY ) Chp^o^k' \hf[bgZmbhgl h_ e^oZfblhe^ Zg] mkb[^g]bfb]bg^ ]b] ghm k^lnem bg Zgr Z]]bmbo^ hk lrg^k`blmb\ ^__^\ml) Dg \hgmkZlm' bg [hma ZllZrl mZk`^mbg` :# HXGYOROKTYOY lb`gb_b\Zgmer ab`a^k @> 0+ oZen^l h_ ma^ \hf[bgZmbhgl bg \hfiZkblhg mh ma^ @> 0+ oZen^l h_ hg^ h_ ma^ lbg`e^ ]kn`l p^k^ h[l^ko^] bg]b\Zmbg` ZgmZ`hgblmb\ ^__^\ml) Dgm^k^lmbg`er' \hf[bgbg` ma^ lZf^ ]kn`l bg Zg OT \O\U ZllZr mZk`^mbg` ma^ lZf^ li^\b^l Zl p^ee Zl ma^ lZf^ eb_^ \r\e^ lmZ`^' ab`a^k ^__b\Z\b^l bg \hfiZkblhg mh ma^ bg]bob]nZe ]kn`l p^k^ h[l^ko^]) Chp^o^k' lbg\^ Z Rbe\hqhg kZgd lnf m^lm Z`Zbglm ma^ ^qi^\m^] oZen^l h_ ma^ lnf h_

-/+ 1USVXKNKTYO\K JOYI[YYOUT ma^ lbg`e^ ]kn` f^]bZgl pZl ghm lb`gb_b\Zgmer ]b__^k^gm _khf ma^ ^__b\Z\r h_ ma^ \hf[bgZmbhgl' Z]]bmbo^' [nm gh lrg^k`blmb\' ^__^\ml \Zg [^ ik^lnf^]) Dm aZl Zek^Z]r [^^g lahpg' maZm \hf[bgZmbhgl h_ e^oZfblhe^ ienl mkb[^g]bfb]bg^ k^lnem bg o^kr ]bo^kl^ ^__^\ml) Nrg^k`blmb\ ^__^\ml h_ mkb[^g]bfb]bg^ Zg] e^oZfblhe^ aZo^ [^^g k^ihkm^] Z`Zbglm /# IK_RGTOI[S G. OT \OZXU Zg] Z`Zbglm Z]nem /# IK_RGTOI[S OT \O\U ' pa^k^Zl lb`gb_b\Zgm ZgmZ`hgblmb\ ^__^\ml aZo^ [^^g h[l^ko^] Z`Zbglm G. h_ 6# HGQKXO OT \OZXU Zg] Z]nem 6# HGQKXO OT \O\U V3-W) Nbg\^ ma^ \hfihlbmbhg h_ <>aMl oZkb^l [^mp^^g ]b__^k^gm g^fZmh]^ li^\b^l' ]b__^k^gm l^ml h_ ln[ngbml fb`am ^qieZbg ]b__^k^gm l^glbmbobmb^l mh bg]bob]nZe \ahebg^k`b\ Zgma^efbgmb\l Zl Zek^Z]r h[l^ko^] bg ;# JKTZGZ[S V/0W) Dg Z]]bmbhg' bm aZl [^^g lahpg _hk /# IGTOT[S! maZm ma^ <>aM ln[ngbm ihineZmbhgl oZkr ]nkbg` ]b__^k^gm eb_^\r\e^ lmZ`^l' k^lnembg` bg ]b__^k^gm lnl\^imb[bebmb^l mh \ahebg^k`b\ ]kn`l Zl p^ee V3.W) Chp^o^k' bg [hma ^qi^kbf^gml' Z]nem :# HXGYOROKTYOY p^k^ mZk`^m^] Zg] ma^k^_hk^' ma^ lZf^ ln[l^m h_ <>aMl lahne] aZo^ [^^g ik^l^gm) Nnkikblbg`er' ZgmZ`hgblmb\ ^__^\ml p^k^ h[l^ko^] OT \OZXU ' pa^k^Zl Z]]bmbo^ ^__^\ml p^k^ ]^m^\m^] OT \O\U ) Oa^ k^Zlhg _hk mabl lmkbdbg` ]b__^k^g\^ k^fZbgl ngdghpg' [nm h[obhnler ma^ OT \OZXU ^oZenZmbhg h_ \ahebg^k`b\ ]kn` \hf[bgZmbhgl bl ghm lnbmZ[e^ fh]^e _hk \hg\enlbhgl hg ma^bk \hf[bgZmhkr [^aZobhnk OT \O\U ) Oa^k^_hk^' \hf[bgZmbhgl h_ \ahebg^k`b\ ]kn`l lahne] hger [^ bgo^lmb`Zm^] OT \O\U bg ma^ eb_^ \r\e^ lmZ`^ h_ bgm^k^lm6 hma^kpbl^ pkhg` \hg\enlbhgl \hne] [^ ]kZpg) Oa^ ^__^\ml h_ \hf[bgZmbhgl h_ \r\ehh\mZ]^ilbi^imb]^l pbma Zfbghia^greZfb]bg^l aZo^ ghm [^^g k^ihkm^] ik^obhnler) Oa^ Zfbghia^greZfb]bg^l Z\mboZm^ <>aMl f^Zgbg` maZm ma^r lmbfneZm^ ma^ ^q\bmZmhkr lrlm^f V/2W' pa^k^Zl ma^ \r\ehh\mZ]^ilbi^imb]^l \Znl^ fnl\e^ k^eZqZmbhg obZ NGJ(, V.,W) Nbg\^ [hma ]kn`l aZo^ ^gmbk^er ]b__^k^gm fh]^l h_ Z\mbhg' Z]]bmbo^ ^__^\ml h_ ]kn`l _khf [hma ]kn` \eZll^l fb`am [^ ^qi^\m^]) Dgm^k^lmbg`er' \hf[bgZmbhgl h_ KA,+--< pbma mkb[^g]bfb]bg^ Zl p^ee Zl pbma ]

-/, 1NGVZKX ,

/&)) Fc[[O`g O\R ]cbZ]]Y

Oh \hg\en]^' ma^ \r\ehh\mZ]^ilbi^imb]^l KA,+--< Zg] ^fh]^ilb]^ Zg] ma^ Zfbghia^gre( Zfb]bg^l ]

-/- 1USVXKNKTYO\K JOYI[YYOUT mZk`^ml Zk^ Z__^\m^]) Chp^o^k' lZ_^mr Zg] iaZkfZ\heh`r h_ [hma ]kn` \eZll^l' ^li^\bZeer bg \hf[bgZmbhg' g^^] mh [^ nk`^gmer bgo^lmb`Zm^] bg Z lZmbl_Z\mhkr fZgg^k _hk kh]^gm fh]^el Zl p^ee Zl _hk anfZgl Zg] ebo^lmh\d)

-/. 1NGVZKX ,

/&)* ESTS`S\QSa

,) HZgsZgbeeZ(Ghivl MC' @oZgl F' =kb]`^ E' -++/' KeZgm ]bl^Zl^l \Znl^] [r g^fZmh]^l' Dg5 >a^g US' >a^g RT' >a^g NT' ?b\dlhg ?R #@]l)$' I^fZmheh`r5 <]oZg\^l Zg] K^kli^\mbo^l Qhe -5 I^Zfmh]^ HZgZ`^f^gm Zg] PmbebsZmbhg) ><=D Kn[eblabg`' RZeebg`_hk]) -) F^bl^k E' Pmsbg`^k E' -++4' Ahh]([hkg^ mk^fZmh]bZl^l) >ebg Hb\kh[bhe M^o --5 /11( /3.) .) >kZb` K' Dmh <' -++2' Dgm^lmbgZe \^lmh]^l) >nkk Jibg Dg_^\m ?bl -+' 0-/(0.-) /) =^mahgr E' =khhd^k N' ?' -+,,' Kkh`k^ll Zg] \aZee^g`^l bg ma^ ]bl\ho^kr h_ fZ\kh_beZkb\b]Ze ]kn`l) @qi^km M^o ebg Hb\kh[bhe Dg_^\m ,2' 422(430) 4) NninmmZfhg`dhe T' Kk^fZlZmabZg I' =anfbfnZg` F' RZrpZ ?' Ibe`Zgnphg` N' FZkniahg` @' Zkmar EN' BZk\bZ CC' TZg` BE' NkbiZ =' Gnlmb`fZg N' -+,-' < k^l^Zk\a Z`^g]Z _hk a^efbgma ]bl^Zl^l h_ anfZgl5 bgm^ko^gmbhg _hk \hgmkhe Zg] ^ebfbgZmbhg) KGhN I^`e Okhi ?bl 1' ^,0/4) ,,) CZk]^k <' -++-' >a^fhma^kZi^nmb\ ZiikhZ\a^l mh mk^fZmh]^l #^q\^im l\ablmhlhf^l$ Zg] \^lmh]^l5 \nkk^gm e^o^e h_ dghpe^]`^ Zg] hnmehhd) KZkZlbmhe M^l 33' 032(04+) ,-) =hpfZg ??' -+,-' C^Zkmphkfl' fZ\kh\r\eb\ eZ\mhg^l' Zg] ma^ li^\m^k h_ k^lblmZg\^ mh ik^o^gmbhg bg ma^ Pgbm^] NmZm^l) KZkZlbm Q^\mhkl 0' ,.3) ,.) Rhelm^gahef^ ' -++/' ?kn` k^lblmZg\^ bg o^m^kbgZkr a^efbgmal) Ok^g]l KZkZlbmhe -+' /14(/21)

-// 1USVXKNKTYO\K JOYI[YYOUT

,/) Rhelm^gahef^ nkk KaZkf =bhm^\aghe ,.' 32.(332) ,0) Nnma^keZg] D<' G^Zmapb\d ?H' -+,,' ' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 fh]^eebg` lmkZm^`b\ nl^ h_ Z g^p Zgma^efbgmb\ \eZll mh lehp ma^ ]^o^ehif^gm h_ k^lblmZg\^ mh ^qblmbg` \eZll^l) I U Q^m E 02' -+.(-+2) ,3) G^Zmapb\d ?H' Chldbg` =>' =bll^m N<' H\FZr >C' -++4' HZgZ`bg` Zgma^efbgmb\ k^lblmZg\^5 bl bm _^Zlb[e^ bg I^p U^ZeZg] mh ]^eZr ma^ ^f^k`^g\^ h_ k^lblmZg\^ mh Z g^p Zgma^efbgmb\ \eZll: I U Q^m E 02' ,3,(,4-) ,4) B^Zkr OB' Chldbg` =>' Ndn\^ KE' ohg NZflhg(Cbff^elmc^kgZ B' HZ^]^k N' Che]lphkma K' Khfkhr R' Q^k\knrll^ E' -+,-' Rhke] ebg Dg_^\m ?bl 0,' ,/-+(,/-3) --) Ni^b\a ='

-/0 1NGVZKX ,

-/) Rheep^[^k C' Ib^f^kl @' Aen\d^ R' ahg` R' -++0' Okb[^g]bfb]bg^5 Z ikhfblbg`' lZ_^ Zg] [khZ](li^\mknf Zgma^efbgmb\ Z`^gm _khf >abgZ) <\mZ Okhi 4/' ,( ,/) -1) Nm^bgfZgg K' Uahn SI' ?n UR' EbZg` ET' SbZh NC' Rn US' Uahn C' Pmsbg`^k E' -++3' Okb[^g]bfb]bg^ Zg] Ze[^g]Zshe^ _hk mk^Zmbg` lhbe(mkZglfbmm^] a^efbgmal' >ZXUTM_RUOJKY YZKXIUXGROY Zg] ?GKTOG lii)5 hi^g(eZ[^e kZg]hfbs^] mkbZe) KGhN I^`e Okhi ?bl -' ^.--) -2) SbZh NC' Pmsbg`^k E' OZgg^k H' F^bl^k E' Sn^ E' -+,.' <]oZg\^l pbma ma^ >abg^l^ Zgma^efbgmab\ ]kn` mkb[^g]bfb]bg^ bg \ebgb\Ze mkbZel Zg] eZ[hkZmhkr bgo^lmb`Zmbhgl) <\mZ Okhi ,-1' ,,0(,-1) -3) Nbe^l(Gn\Zl H' C^fiabee <' -++-' >^lmh]^ iZkZlbm^l5 Ziieb\Zmbhg h_ OT \O\U Zg] OT \OZXU fh]^el _hk lmn]b^l hg ma^ ahlm(iZkZlbm^ k^eZmbhglabi) <]o KZkZlbmhe 0,' ,..(-.+) -4) Nfhnm HE' Fhms^ <>' H\>Zkmar EN' GhndZl <' -+,+' < gho^e ab`a makhn`ainm ZllZr _hk Zgma^efbgmb\ ]kn` l\k^^gbg` Zg] k^lblmZg\^ ]bZ`ghlbl [r k^Ze(mbf^ fhgbmhkbg` h_ iZkZlbm^ fhmbebmr) KGhN I^`e Okhi ?bl /' ^330) .+) CZk]^k <' N\afbmm(Rk^]^ CK' Fk{\d^g E' HZkbgholdb K' Rng]^keb\a A' Rbeelhg E' r\ehh\mZ]^ilbi^imb]^l ( Zg Zgma^efbgmb\Zeer Z\mbo^ \eZll h_ \hfihng]l ^qab[bmbg` Z gho^e fh]^ h_ Z\mbhg) Dgm E hgghk Q' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' hnkmg^r F?'

-/1 1USVXKNKTYO\K JOYI[YYOUT

.0) ?bZpZkZ <' ?kZd^ GE' Nnlpbeeh MM' FbaZkZ E' =ng]r ?<' N\hmm H@' CZei^ggr >' NmhmaZk] EM' Kkb\aZk] MF' -++4' @' =kZ]e^r E@' =^agd^ EH' HZmma^pl FM' @el^ FE' -++0' DlheZm^l h_ ?XOIN[XOY S[XOY ^eb\bm ]b__^k^gm Z]Zimbo^ bffng^ k^lihgl^l bg ma^bk fnkbg^ ahlm) KZkZlbm^ Dffnghe -2' 14(23) /+) KZg^lZk ON' >khee I<' ,43+' Oa^ eh\Zmbhg h_ iZkZlbm^l pbmabg ma^bk ahlml5 lbm^ l^e^\mbhg [r ?XOIN[XOY S[XOY bg ma^ eZ[hkZmhkr fhnl^) Dgm E KZkZlbmhe ,+' -1,(-2.) /,) Kbd^ @C' ,414' @`` hnminm h_ ?XOIN[XOY S[XOY #N\akZgd' ,233$ ) E KZkZlbmhe 00' ,+/1( ,+/4) /-) B^Zkr OB' Rhh F' H\>Zkmar EN' HZ\d^gsb^ >?' Chkmhg E' Kkb\aZk] MF' ]^ NbeoZ IM' JeebZkh KG' GZs]bgl(C^e]l EF' @g`^el ?<' =ng]r ?<' -+,+' Pgk^lheo^] blln^l bg Zgma^efbgmb\ iaZkfZ\heh`r _hk a^efbgmabZl^l h_ anfZgl) Dgm E KZkZlbmhe /+' ,(,.) /.) TnZg B' Sn E' Ln O' RZg` =' UaZg` M' R^b >' Bnh M' -+,+' H^mZ[heblf Zg] ]blihlbmbhg h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l bg a^Zemar >abg^l^ ohengm^^kl) ?kn`l M ? ,+' 3.(4+) //) Sn^ E' SbZh NC' Sn GG' LbZg` CL' -+,+' Oa^ ^__^\m h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Z`Zbglm :KIGZUX GSKXOIGT[Y bg `he]^g aZflm^kl Zg] :OVVUYZXUTM_R[Y HXG`OROKTYOY bg kZml) KZkZlbmhe M^l ,+1' 220(23,) /0) =nqmhg NF' >aZko^m >G' I^o^n >' >Z[Zk^m E' >hkm^m E' K^bg^Zn I' <[hg`pZ H' >hnkmhm @' Mh[^kmlhg aMl) KGhN KZmah` ,+' ^,++.32+) /1) HZkmbg EH' Knk\^ee E' Mh[^kmlhg M> Kk^ll' =h\Z MZmhg)

-/2 1NGVZKX ,

/2) Cn T' SbZh NC' a^g R' O^kZ]Z H' >a^g` EO' ,441' >aZkZ\m^kbsZmbhg h_ ln[mri^l h_ `ZffZ( Zfbgh[nmrkb\ Z\b] k^\^imhkl bg Zg /YIGXOY S[YIRK ik^iZkZmbhg [r [bg]bg` ZllZr Zg] [bg]bg` h_ KA,+--<' Z g^p Zgma^efbgmb\' hg ma^ k^\^imhkl) KZkZlbmhe M^l 3-' 42(,+,) /4) Hbeml\a NH' Fk{\d^g E' ?^f^e^k E' EZgll^g DE' Fk{`^k I' CZk]^k <' ohg NZflhg( Cbff^elmc^kgZ B' -+,-' ?^\k^Zl^] ^fh]^ilb]^ l^glbmbobmr bg ng\(/4 `ZffZ( Zfbgh[nmrkb\ Z\b] #B<=<$(k^\^imhk(]^_b\b^gm 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe /-' 21,(22+) 0+) Rbeelhg E' hhd <' >nmme^ HA' Fkb^d I' Chii^k I<' J">hgghk Q' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -++/' GZmkhmhqbg k^\^imhk lb`gZebg` ^g`Z`^l ma^ PI>(,.(]^i^g]^gm o^lb\e^(ikbfbg` iZmapZr bg 1# KRKMGTY ) >nkk =bhe ,/' ,.2/( ,.24) 0,) NZ^`^k =' N\afbmm(Rk^]^ CK' ?^agaZk]m H' =^gm^g RK' Fk{\d^g E' CZk]^k <' Qhg NZflhg(Cbff^elmc^kgZ B' Rb^`Zg] C' Rng]^keb\a A' -++,' GZmkhiabebg(ebd^ k^\^imhk _khf ma^ iZkZlbmb\ g^fZmh]^ 6GKSUTIN[Y IUTZUXZ[Y Zl mZk`^m _hk ma^ Zgma^efbgmb\ ]^ilbi^imb]^ KA,+--<) Akbl_hk] <' HnkkZr >' J">hgghk Q' @]pZk]l ME' Fk{`^k I' R^es >' ohg NZflhg( Cbff^elmc^kgZ B' CZk]^k <' RZed^k ME' Che]^g(?r^ G' -+,,' N^e^\mbo^ mhqb\bmr h_ ma^ Zgma^efbgmb\ ^fh]^ilb]^ k^o^Ze^] [r a^m^kheh`hnl ^qik^llbhg h_ anfZg F>IH<, bg 1GKTUXNGHJOZOY KRKMGTY ) Hhe KaZkfZ\he 24' ,+.,(,+/.) 0.) R^es >' Fk{`^k I' N\agb^]^kcZgl H' Hbeml\a NH' Fk{\d^g E' Bn^lm H' Che]^g(?r^ G' CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -+,,' NGJ(,(\aZgg^el h_ iZkZlbmb\ g^fZmh]^l k^\hglmbmnm^ eh\hfhmhk [^aZobhnk Zg] ^fh]^ilb]^ l^glbmbobmr bg 1GKTUXNGHJOZOY KRKMGTY leh(, ehll h_ _ng\mbhg fnmZgml) KGhN KZmah` 2' ^,++,..+) 0/) Bn^lm H' =nee F' RZed^k ME' hgghk Q' CZk]^k <' Che]^g(?r^ G' Chii^k I<' -++2' Oa^ \Ze\bnf(Z\mboZm^] ihmZllbnf \aZgg^e' NGJ(,' bl k^jnbk^] _hk ma^ Z\mbhg h_ ma^ gho^e \r\ehh\mZ]^ilbi^imb]^ Zgma^efbgmb\' ^fh]^ilb]^' bg 1GKTUXNGHJOZOY KRKMGTY ) Dgm E KZkZlbmhe .2' ,022(,033) 00) ?n_hnk Q' =^^\a MI' R^o^k >' ?^gm E<' B^Zkr OB' -+,.' Hhe^\neZk \ehgbg` Zg] \aZkZ\m^kbsZmbhg h_ gho^e `enmZfZm^(`Zm^] \aehkb]^ \aZgg^e ln[ngbml _khf >INOYZUYUSG SGTYUTO ) KGhN KZmah` 4' ^,++.031)

-/3 1USVXKNKTYO\K JOYI[YYOUT

01) >aZko^m >G' Mh[^kmlhg Z[Zk^m E' HZkmbg ME' I^o^n >' -+,-' N^e^\mbo^ ^__^\m h_ ma^ Zgma^efbgmb\ [^ia^gbnf hg 6GKSUTIN[Y IUTZUXZ[Y e^oZfblhe^(l^glbmbo^ Z\^mre\ahebg^ k^\^imhkl) Dgo^km I^nkhl\b ,-' /.(0,) 02) H\>Zo^kZ N' Mh`^kl eZ ^qik^ll^] bg CKTUV[Y hh\rm^l _hkfl Z `enmZfZm^(`Zm^] bhg \aZgg^e maZm bl Z\mboZm^] [r b[hm^gZm^ Zg] ma^ ZgmbiZkZlbmb\ ]kn` bo^kf^\mbg) Hhe =bh\a^f KZkZlbmhe ,-4' ,,0(,-,) 04) Mn_^g^k G' =^]hgb I' =Znk M' M^r N' BeZnl^k ?<' =hnob^k E' =^^\a M' Nb`^e @' Knhmb <' -+,.' Z\k(-. ^g\h]^l Z fhg^iZgm^e(l^glbmbo^ \aZgg^e bg 1GKTUXNGHJOZOY KRKMGTY ) KGhN KZmah` 4' ^,++.0-/) 1+) Nb]]bjnb NU' =khpg ??' MZh QO' Ahkk^lm^k NB' -+,+' (/4 B<=< k^\^imhk ln[ngbm _khf ma^ iZkZlbmb\ g^fZmh]^ 6GKSUTIN[Y IUTZUXZ[Y bl Zllh\bZm^] pbma ^gaZg\^] B<=< l^glbmbobmr bg g^fZmh]^ a^m^khf^kb\ \aZgg^el) E I^nkh\a^f ,,.' ,,,.(,,--) 1,) KkZdkbrZ H' Gbg`e^ >E' ,444' =F \aZgg^e Z\mboZmbhg [r [kb^_ ]^iheZkbsZmbhgl k^jnbk^l >Z -& bg_enq makhn`a G( Zg] L(mri^ >Z -& \aZgg^el bg kZm \akhfZ__bg \^eel) E I^nkhiarlbhe 3,' --12(--23) 1-) Rhh]l M<' HZehg^ FH=' ,430' Oa^ ^__^\ml h_ Zfb]Zgm^e #=Zg E Uhhe 1/' ,.,+(,.,1) 1.) SbZh NC' Sn^ E' Sn GG' Ua^g` L' LbZg` CL' UaZg` TI' -++4' Oa^ OT \OZXU Zg] OT \O\U ^__^\m h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Z`Zbglm 1RUTUXINOY YOTKTYOY ) KZkZlbmhe M^l ,+0' ,/42(,0+2) 1/) Rn US' AZg` TT' Gbn TN' -++1' @__^\m h_ Z gho^e ]kn` ( ^gm^kb\ \hZm^] mkb[^g]bfb]bg^ bg ma^ mk^Zmf^gm h_ bgm^lmbgZe g^fZmh]^ bg_^\mbhgl) >abg E h_ KZkZlbmhe Zg] KZkZlbm ?bl -/5 -.Ö-1) 10) @i^ >' FZfbgldr M' -+,.' I^p Z]oZg\^f^gm bg Zgma^efbgmb\ ]kn`l bg o^m^kbgZkr f^]b\bg^) Ok^g]l KZkZlbmhe -4' ,-4(,./) 11) >hg]^k B<' Ehaglhg NN' IhpZdhpldb ?N' =eZd^ O@' ?nmmhg A@' I^elhg NE' OahfZl @H' ?Zobl EK' Oahfilhg ?K' ,440'

-/4 1NGVZKX ,

12) ohg NZflhg(Cbff^elmc^kgZ B' CZk]^k <' N\agb^]^k O' FZe[^ E' H^g\d^ I' -+++' 7T \O\U Z\mbobmb^l h_ ma^ g^p Zgma^efbgmb\ ]^ilbi^imb]^ KA ,+--<) KZkZlbmhe M^l 31' ,4/( ,44) 13) CZk]^k <' ohg NZflhg(Cbff^elmc^kgZ B' -++-' >r\ehh\mZ]^ilbi^imb]^l ( Z g^p \eZll h_ Zgma^efbgmb\Zeer Z\mbo^ \hfihng]l) KZkZlbmhe M^l 33' /3,(/33) 14) RZg` H' RZmZgZ[^ I' NahfnkZ O' Jamhfh C' ,440' @__^\ml h_ KA,+--< hg :OVVUYZXUTM_R[Y HXGYOROKTYOY bg kZml Zg] 6_SKTURKVOY TGTG bg fb\^) Eig E KZkZlbmhe //' .+1(.,+) 2+) JeebZkh K' N^be^k E' Fn^l^e <' Chkmhg E' >eZkd EI' ?hg M' F^bl^k E' -+,,' Khm^gmbZe ]kn` ]^o^ehif^gm \Zg]b]Zm^l _hk anfZg lhbe(mkZglfbmm^] a^efbgmabZl^l) KGhN I^`e Okhi ?bl 0' ^,,.3) 2,) Q^k\knrll^ E' ' Kkb\aZk] MF' H\>Zkmar EN' Hhgmk^lhk <' G^o^\d^ =' -+,,' Dl Zgma^efbgmb\ k^lblmZg\^ Z \hg\^kg _hk ma^ \hgmkhe h_ anfZg lhbe(mkZglfbmm^] a^efbgmal: Dgm E KZkZlbmhe ?kn`l ?kn` M^lblm ,' ,/(-2) 2-) N\abff^e <' aZke^l N' >knma^kl G' Fhd ?E' FkZ^f^k A' Fkb^`^k FE' -++4' @__b\Z\r h_ ^fh]^ilb]^ ienl ikZsbjnZgm^e mZ[e^ml #Kkh_^g]^k mZ[e^ml _hk ]h`l$ Z`Zbglm fZmnk^ Zg] bffZmnk^ Z]nem ?XOIN[XOY \[RVOY bg_^\mbhgl bg ]h`l) KZkZlbmhe M^l ,+0' ,2(--) 2.) H^aeahkg C' N\afZae B' Ak^l^ H' H^obll^g D' CZk]^k <' Fkb^`^k F' -++0' @__^\ml h_ Z \hf[bgZmbhgl h_ ^fh]^ilb]^ Zg] ikZsbjnZgm^e hg iZkZlbm^l h_ k^imbe^l Zg] kh]^gml) KZkZlbmhe M^l 42' 10(14) 2/) HZkmbg ME' Mh[^kmlhg aZko^m >G' I^o^n >' -+,-' G^oZfblhe^ k^\^imhkl5 Z l^\hg] ZpZd^gbg`) Ok^g]l KZkZlbmhe -3' -34(-41) 20) =eZqm^k HG' ?^ G^r K' BZk^r EM' Gbn GS' N\a^e]^fZg K' Qb^klmkZ^m^ <' QZg_e^m^k^g EM' HZ\d^r GT' ?hkkbl H' Akbll^ GH' Qb]Z EO' OahfZl RF' ,443' < fhe^\neZk ^ohenmbhgZkr _kZf^phkd _hk ma^ iarenf I^fZmh]Z) IZmnk^ .4-' 2,(20) 21) Nmnk\ae^k ?' ,43-' >a^fhma^kZir h_ anfZg bgm^lmbgZe a^efbgmabZl^l5 Z k^ob^p' pbma iZkmb\neZk k^_^k^g\^ mh \hffngbmr mk^Zmf^gm) <]o KaZkfZ\he >a^fhma^k ,4' ,-4(,0/) 22) Nfbma H>' Na^kfZg ?H' -++4' BhZm f^]b\bg^) Rbe^r(=eZ\dp^ee'

-0+ 1USVXKNKTYO\K JOYI[YYOUT

24) =^gg^m @H' =^af >' =krZgm >' ,423' @__^\ml h_ f^[^g]Zshe^ Zg] e^oZfblhe^ hg m^mkZmarkb]bZ h_ 9KYUIKYZUOJKY IUXZO bg ma^ fhnl^) Dgm E KZkZlbmhe 3' /1.(/11) 3+) M^bg^f^r^k >M' Cnm\a^gl ?@' @\d[eZ] RK' HZk\abhg]h <<' Nan`Zkm ED' -++1' ?hl^(\hg_bkfZmbhg lmn]b^l h_ ma^ \^lmh\b]Ze Z\mbobmr h_ irkZgm^e iZfhZm^ iZlm^ bg ahkl^l) Q^m KZkZlbmhe ,.3' -./(-.4) 3,) HZk\abhg]h <<' Rabm^ BR' Nfbma GG' M^bg^f^r^k >M' ?Zl\Zgbh EE' Ehaglhg @B' Nan`Zkm ED' -++1' >ebgb\Ze _b^e] ^__b\Z\r Zg] lZ_^mr h_ irkZgm^e iZfhZm^ iZlm^ #,4),. p*p irkZgm^e [Zl^$ Z`Zbglm /TUVRUIKVNGRG lii) bg gZmnkZeer bg_^\m^] ahkl^l) Q^m KZkZlbmhe ,.2' 4/(,+-) 3-) Okbmm^g G' Iphln P' QZk`Zl H' F^bl^k E' -+,-' 7T \OZXU Zg] OT \O\U ^__b\Z\r h_ mkb[^g]bfb]bg^ Zg] bml f^mZ[hebm^l Zehg^ Zg] bg \hf[bgZmbhg Z`Zbglm ma^ ahhdphkfl 6KROMSUYUSUOJKY HGQKXO Zg] /TI_RUYZUSG IK_RGTOI[S ) <\mZ Okhi ,--' ,+,(,+2) 3.) Fhms^ <>' Ghp^ <' J"BkZ]r E' Fhii NM' =^agd^ EH' -++4' ?hl^(k^lihgl^ ZllZr m^fieZm^l _hk OT \OZXU Zll^llf^gm h_ k^lblmZg\^ mh [^gsbfb]Zshe^ Zg] gb\hmbgb\ Z\^mre\ahebg^ k^\^imhk Z`hgblm ]kn`l bg anfZg ahhdphkfl)

-0,

6VO^bS` 0

Fc[[O`g ' LcaO[[S\TOaac\U

1NGVZKX -

0 Fc[[O`g' LcaO[[S\TOaac\U

0&) Fc[[O`g

KZkZlbmb\ a^efbgmal bg\en]bg` \^lmh]^l' mk^fZmh]^l Zg] g^fZmh]^l' aZo^ Zg ^ghkfhnl bfiZ\m hg anfZg Zg] ZgbfZe a^Zema Zg] \Znl^ mk^f^g]hnl _bgZg\bZe ehll^l) Oa^k^_hk^' ma^ nk`^gm ]^fZg] _hk fh]^kg Zg] lZ_^ mk^Zmf^gm himbhgl Z`Zbglm a^efbgmahl^l bl h[obhnl) Dg Z]]bmbhg mh ma^ himbfblZmbhg h_ ^qblmbg` ]kn` \eZll^l' mph fZchk h[c^\mbo^l Zk^ bg ma^ _h\nl h_ k^l^Zk\a mh bg\k^Zl^ mk^Zmf^gm himbhgl Z`Zbglm a^efbgma bg_^\mbhgl5 #b$ ma^ ^oZenZmbhg h_ \hf[bgZmbhgl' mh bg\k^Zl^ ma^ Zgma^efbgmb\ li^\mknf' mh bfikho^ ma^ ^__b\Z\r h_ ma^ k^li^\mbo^ ]kn`l Zg] mh ]^\^e^kZm^ ma^ ]^o^ehif^gm h_ k^lblmZg\^ Zg] #bb$ ma^ b]^gmb_b\Zmbhg Zg] ]^o^ehif^gm h_ lZ_^ Zg] ab`aer ^__b\Z\bhnl g^p ]kn` \eZll^l pbma gho^e' k^lblmZg\^([k^Zdbg` fh]^l h_ Z\mbhg) Oa^ ik^l^gm \nfneZmbo^ ma^lbl' \hglblmbg` h_ _bo^ in[eb\Zmbhgl' ]^l\kb[^l bgo^lmb`Zmbhgl Z]]k^llbg` [hma h_ ma^ Z[ho^ f^gmbhg^] Zli^\ml [r \hfiZkbg` ma^ ihm^gmbZe h_ ma^ Zfbghia^greZfb]bg^l Zfb]Zgm^e' mkb[^g]bfb]bg^ Zg] ]^Z\reZm^] Zfb]Zgm^e #]hgl^jn^gmer' bg in[eb\Zmbhg . ma^ lZf^ ]^kboZmbo^l p^k^ _hng] mh [^ ab`aer ^__b\Z\bhnl nlbg` ma^ :# HXGYOROKTYOY OT \O\U fh]^e bg kZml) Hhk^ho^k' m^lm^] ]kn` \hf[bgZmbhgl h_ mph \ahebg^k`b\ ]kn`l hk Zg Zfbghia^greZfb]bg^ ienl Z \r\ehh\mZ]^ilbi^imb]^ k^lnem^] bg Z]]bmbo^ ^__^\ml' fZdbg` ghm hger ma^ bg]bob]nZe ]kn`l [nm Zelh \hf[bgZmbhgl bgm^k^lmbg` _hk _nkma^k ^oZenZmbhg) Ankma^kfhk^' Z iaZkfZ\hdbg^mb\ ZgZerlbl k^o^Ze^] maZm Z_m^k hkZe Z]fbgblmkZmbhg h_ mkb[^g]bfb]bg^' hger bml f^mZ[hebm^ ][SSGX_$D[YGSSKTLGYY[TM bg_hkfZmbhg Z[hnm ma^bk fh]^ h_ Z\mbhg) Rhkfl mk^Zm^] pbma KA,+--< lahp^] lb`gl h_ _eZ\\b] iZkZerlbl' pa^k^Zl bg]bob]nZel mk^Zm^] pbma \ahebg^k`b\ ]kn`l bg\en]bg` Zfbghia^greZfb]bg^l Zg] e^oZfblhe^' lahp^] lmkhg` \hgmkZ\mbhg Zehg` ma^ pahe^ [h]r h_ ma^ phkf ln``^lmbg` liZlmb\ iZkZerlbl) Aheehpbg` ma^ ^lmZ[eblaf^gm Zg] iZkZlbmheh`b\Ze \aZkZ\m^kblZmbhg h_ Z ?XOIN[XOY S[XOY fhnl^ fh]^e' in[eb\Zmbhg / bgo^lmb`Zm^] ma^ OT \O\U ihm^g\r h_ ma^ Zfbghia^greZfb]bg^l Zg] ma^ \r\ehh\mZ]^ilbi^imb]^l Z`Zbglm iZm^gm pabiphkf bg_^\mbhgl nlbg` mak^^ \hgl^\nmbo^ ]hlZ`^l [r ]b__^k^gm khnm^l h_ Z]fbgblmkZmbhg) Jger mk^Zmf^gml pbma k^eZmbo^er ab`a ]hlZ`^l h_ mkb[^g]bfb]bg^ hk ]

-00 1NGVZKX -

0&* LcaO[[S\TOaac\U C^efbgmahl^g' a^kohk`^kn_^g ]nk\a >^lmh]^g' Ok^fZmh]^g ng] I^fZmh]^g' o^knklZ\a^g ^ghkf^ `^lng]a^bmeb\a^ N\au]^g [^b H^gl\a^g ng] Ob^k^g ng] lbg] _{k `^pZemb`^ zdhghfbl\a^ N\au]^g o^kZgmphkmeb\a) ?^k bff^gl^ =^]Zk_ Zg fh]^kg^g \a^fhma^kZi^nmbl\a^g Hz`eb\ad^bm^g snk =^dufi_ng` ohg Rnkf^kdkZgdng`^g blm ]Za^k h__^glb\ameb\a) I^[^g ]^k Jimbfb^kng` ]^k ohkaZg]^g^g KkuiZkZm^ ' lm^a^g sp^b p^bm^k^ s^gmkZe^ C^kZnl_hk]^kng`^g bf Ahdnl ]^k Rbll^gl\aZ_m5 #b$ ?b^ @oZenb^kng` ohg Fhf[bgZmbhglikuiZkZm^g' p^e\a^ ]Zl Rbkdng`lli^dmknf ^kp^bm^kg lhpb^ ]b^ RbkdlZfd^bm `^`^g li^sb_bl\a^ Ni^sb^l ^kaza^g' Z[^k Zn\a ]^k @gmpb\deng` ohg ah\ak^lblm^gm^g RnkfihineZmbhg ^gm`^`^gpbkd^g lhee^g' ng] #bb$ ]b^ @k_hkl\ang` ohg ah\apbkdlZf^g ng] lb\a^k^g g^n^g KkuiZkZm^g' p^e\a^ fbm Zem^kgZmbo^g Rbkdf^\aZgblf^g k^lblm^gs[k^\a^g]^ @b`^gl\aZ_m^g aZ[^g ng] _he`eb\a ]b^ ma^kZi^nmbl\a^g Hz`eb\ad^bm^g ^kp^bm^kg dzgg^g) ?b^ ohkeb^`^g]^ dnfneZmbo^ ?bll^kmZmbhg' [^lm^a^g] Znl _{g_ pbll^gl\aZ_meb\a^g

-01 >[SSGX_$D[YGSSKTLGYY[TM

Pgm^kln\ang` _^lm`^lm^eem' ]Zll gZ\a hkZe^k BZ[^ ohg Okb[^g]bfb]bg Znll\aeb^~eb\a ]^ll^g H^mZ[hebm' ]^Z\reb^km^l {kf^k' ]b^ fbm KA,+--< [^aZg]^em pnk]^g' fhkiaheh`bl\a^ aZkZdm^kblb^kng` ^bg^l ?# S[XOY (HZnl(Hh]^eel [^aZg]^em

-02

6VO^bS` 1

?Wab ]T ^cPZWQObW]\a

1NGVZKX .

1 ?Wab ]T ^cPZWQObW]\a

Oa^ ik^l^gm DgZn`nkZe(?bll^kmZmbhg pZl ln[fbmm^] Zl Z \nfneZmbo^ ma^lbl) Oa^ _heehpbg` Zkmb\e^l p^k^ mZd^g Zl Z [Zlbl _hk mabl ]bll^kmZmbhg5

D)$ $1+*) " , $/4(*)- # , &)+3 ! , 2.- %',0.- (Cbff^elmc^kgZ B)' CZk]^k <) "2 9/93 STTWQOQg ]T bVS O\bVSZ[W\bWQ b`WPS\RW[WRW\S OUOW\ab bVS QSab]RS !:1,230,4/6 1/+536731) W\ O Q]\b`]ZZSR ZOP]`Ob]`g b`WOZ <\mZ Okhib\Z -+,-' ,-. #-$5 23(3/) DD)$ %4.-+ " , %26)-+0 $ , "+/+.+2 $ , #(2*+2 ! , &+,.,120 # , 510 '(/310 (Cbff^elmc^kgZ B) "2 9/753 STTWQOQg ]T QgQZ]]QbORS^aW^S^RbWRSa O\R O[W\]^VS\gZO[WRW\Sa OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab bVW`R abOUS ZO`dOS O\R ORcZb e]`[a ]T #/44367532-:086 *5)6/0/,26/6 O\R TW`ab abOUS ZO`dOS ]T '5/+./2,00) 64/5)0/6 KZkZlbmheh`r M^l^Zk\a -+,.' ,,- #,$5 ..0(./0) DDD)$ Fned^ ?)' Fk{\d^g E)' CZk]^k <)' Fk^[[^k M)' AkZZms' F)' H^aeahkg C)' ohg NZflhg( Cbff^elmc^kgZ B) "2 9/93 STTWQOQg ]T C9)(**4 O\R \WQ]bW\WQ OQSbgZQV]ZW\S `SQS^b]` OU]\Waba OZ]\S O\R W\ Q][PW\ObW]\ OUOW\ab #/44367532-:086 *5)6/0/,26/6 KZkZlbmheh`r -+,.' ,/+ #,+$5 ,-0-(,-10) DQ)$ Fned^ ?)' Fk{\d^g E)' CZk]^k <)' ohg NZflhg(Cbff^elmc^kgZ B) 8TTWQOQg ]T QgQZ]]QbORS^aW^S^bWRSa O\R O[W\]^VS\gZO[WRW\Sa OUOW\ab ZO`dOZ$ W[[Obc`S O\R [Obc`S ORcZb abOUSa ]T O ^O`OaWb]Z]UWQOZZg QVO`OQbS`WhSR b`WQVc`]aWa []RSZ W\ [WQS KGhN I^`e^\m^] Okhib\Ze ?bl^Zl^l -+,/' 3 #-$5 ^-143) Q)$ Fned^ ?)' ohg NZflhg(Cbff^elmc^kgZ B)' Hbeml\a N)' Rhelm^gahef^ <)E)' E^q <)M)' BZll^k M)=)' =Zee^lm^khl >)' B^Zkr O)' F^bl^k E)' Ohpglhg N)' CZk]^k <)' Fk{\d^g E) 6VO`OQbS`WaObW]\ ]T bVS QOZQWc[%UObSR O\R d]ZbOUS%RS^S\RS\b ^]bOaaWc[ QVO\\SZ F?B%) ]T \S[Ob]RSa O\R Wba W\bS`OQbW]\ eWbV S[]RS^aWRS Nn[fbmm^] mh KGhN KZmah`^gl

-1+ 8OYZ UL V[HROIGZOUTY

KZkml h_ mabl ma^lbl aZo^ [^^g ik^l^gm^] Zg] in[ebla^] ik^obhnler5

D)$ Fned^ ?) <\dSabWUObW]\a ]\ bVS STTSQba ]T \WQ]bW\S`UWQ R`cUa O\R QgQZ]]QbORS^aW^S^bWRSa OZ]\S ]` W\ Q][PW\ObW]\ OUOW\ab #/44367532-:086 *5)6/0/,26/6 W\ `Oba ?biehfZ ma^lbl #C^bgkb\a(C^bg^(Pgbo^klbmum ?{ll^e]hk_$5 ?{ll^e]hk_' -++4 DD)$ Fned^ ?)' CZk]^k <) 8TTWQOQg ]T b`WPS\RW[WRW\S OUOW\ab bVS QSab]RS !:1,230,4/6 1/+536731) W\ Sf^S`W[S\bOZZg W\TSQbSR [WQS =bZggnZe H^^mbg` h_ ma^ B^kfZg Nh\b^mr h_ KZkZlbmheh`r #?BK$5 ?{ll^e]hk_' -+,+ Dgm^kgZmbhgZe >hg`k^ll h_ KZkZlbmheh`r #D>JK<$5 H^e[hnkg^' -+,+ DDD)$ Fned^ ?)' CZk]^k <) 8TTWQOQg ]T b`WPS\RW[WRW\S W\ Q][^O`Wa]\ b] ZSdO[Wa]ZS OUOW\ab bVS \S[Ob]RS #/44367532-:086 *5)6/0/,26/6 W\ Sf^S`W[S\bOZZg W\TSQbSR `Oba =bZggnZe H^^mbg` h_ ma^ B^kfZg Nh\b^mr h_ KZkZlbmheh`r #?BK$5 ?{ll^e]hk_' -+,+ Dgm^kgZmbhgZe >hg`k^ll h_ KZkZlbmheh`r #D>JK<$5 H^e[hnkg^' -+,+ DQ)$ Fned^ ?)' Fk{\d^g E)' CZk]^k <)' Ohpglhg N)' ohg NZflhg(Cbff^elmc^kgZ B) O\iZS\ W\ $2+.3+,5+) -8778536) c\R '5/+.85/6 185/6 2 8W\VSWbZWQVS` JW`Y[SQVO\Wa[ca d]\ 8[]RS^aWR USUS\ ^O`OaWbWaQVS AS[Ob]RS\3 hg_^k^g\^ h_ ma^ Rhke]

-1, 1NGVZKX .

QD)$ Fned^ ?)' Fk{\d^g E)' R^es >)' CZk]^k <)' ohg NZflhg(Cbff^elmc^kgZ B) GVS '5/+.85/6 185/6 US\][S S\Q]RSa be] V][]Z]Ua ]T F?B%) QOZQWc[% O\R d]ZbOUS% OQbWdObSR ^]bOaaWc[ QVO\\SZa2 VW\ba T]` O RWTTS`S\b aS\aWbWdWbg b] bVS O\bVSZ[W\bWQ S[]RS^aWRS3 Nrfihlbnf hg H^f[kZg^ Dhg >aZgg^el bg C^efbgma KZkZlbm^l' M^lblmZg\^ Zg] Nbm^l h_ <\mbhg _hk )' CZk]^k <)' ohg NZflhg(Cbff^elmc^kgZ B) @]`S RWdS`aS bVO\ Sf^SQbSR2 GVS ^cbObWdS S[]RS^aWRS bO`USb F?B%) aV]ea Q]\aWRS`OPZS VSbS`]US\SWbg PSbeSS\ RWTTS`S\b QZORSa ]T \S[Ob]RSa )' B^Zkr O)' F^bl^k E)' Fk{\d^g E) 6]\aWRS`OPZS VSbS`]US\SWbg ]T bVS 6O *# %OQbWdObSR O\R d]ZbOUS%UObSR > #%QVO\\SZ F?B%) PSbeSS\ RWTTS`S\b QZORSa ]T \S[Ob]RSa O\R bVS ^]bS\bWOZ W[^OQb ]\ bVS W\bS`OQbW]\ ]T F?B%) O\R S[]RS^aWRS Dgm^kgZmbhgZe >hg_^k^g\^ h_ ma^ Rhke] )' B^Zkr O)' F^bl^k E)' ohg NZflhg(Cbff^elmc^kgZ B)' CZk]^k <)' Fk{\d^g E) CVgZ]US\SbWQ O\OZgaWa ]T \S[Ob]RS F?B%) O\R SZSQb`]^VgaW]Z]UWQOZ QVO`OQbS`WaObW]\ ]T F?B%) W\ KS\]^ca ]]QgbSa

-1- 8OYZ UL V[HROIGZOUTY

Oa^ bg]bob]nZe \hgmkb[nmbhgl h_ ?Zgb^e Fned^ Zk^ lmZm^]5

KZi^k D KZi^k DD KZi^k DDD KZi^k DQ KZi^k Q

Dfie^f^gmZmbhg h_ lmn]b^l _hk iZi^k DD5 ?) Fned^ i^k_hkf^] Zg] in[ebla^] mph k^ieb\Zm^l h_ ^Z\a h_ ma^ OT \OZXU ZllZrl bg abl ]biehfZ ma^lbl)

Dfie^f^gmZmbhg h_ lmn]b^l _hk iZi^k DDD5 ?) Fned^ i^k_hkf^] Zg] in[ebla^] l^o^kZe mk^Zmf^gm k^`bf^gl h_ \r\ehh\mZ]^ilbi^imb]^l Zg] \ahebg^k`b\ ]kn`l Zehg^ Zg] bg \hf[bgZmbhg Z`Zbglm :# HXGYOROKTYOY bg kZml bg abl ]biehfZ ma^lbl) ?) Fned^ Zelh i^k_hkf^] Zg] in[ebla^] ma^ l\Zggbg` ^e^\mkhg fb\khl\hir lmn]b^l bg abl ]biehfZ ma^lbl)

Dfie^f^gmZmbhg h_ lmn]b^l _hk iZi^k DDD5 M) Fk^[[^k i^k_hkf^] ma^ ZgZerlbl h_ ma^ ieZlfZ lZfie^l _hk ma^ iaZkfZ\hdbg^mb\ lmn]r [r mnk[ne^gm _ehp \akhfZmh`kZiar \hnie^] pbma Z mZg]^f fZll li^\mkhf^mkr ]^m^\mhk)

Dfie^f^gmZmbhg h_ lmn]b^l _hk iZi^k Q5 N) Hbeml\a i^k_hkf^] ma^ Zfieb_b\Zmbhg' \ehgbg` Zg] l^jn^g\bg` h_ Zl\Zkb] leh(, \?I) =Zee^lm^khl i^k_hkf^] blheZmbhg h_ 0# SGRG_O MI< Zg] mkZgl\kbimbhg h_ ma^ k^li^\mbo^ \?I<)

-1. Chapter 9

The co-authors of the five publications confirm in all conscience, that the stated contributions of Daniel Kulke are declared truthfully.

For reasons of data protection, Signatures of co-authors are not included in the online version

264 Chapter 10

Curriculum vitae Chapter 10

10 Curriculum vitae

For reasons of data protection, the curriculum vitae is not included in the online version

266 Curriculum vitae

For reasons of data protection, the curriculum vitae is not included in the online version

267 Chapter 10

For reasons of data protection, the curriculum vitae is not included in the online version

268 Curriculum vitae

For reasons of data protection, the curriculum vitae is not included in the online version

269 Chapter 10

For reasons of data protection, the curriculum vitae is not included in the online version

270 Chapter 11

Appendices Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1016/j.actatropica.2012.03.008” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1007/s00436-012-3141-1” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version.

Publisher´s version of the article “http://dx.doi.org/10.1017/S0031182013000632” is not included in the online version. Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice

Daniel Kulke 1,2 , Ju ¨ rgen Kru¨ cken1*, Achim Harder 3, Georg von Samson-Himmelstjerna 1 1 Institute of Parasitology and Tropical Veterinary Medicine, Freie Universita¨t Berlin, Berlin, Germany, 2 Global Drug Discovery – Animal Health – Parasiticides, Bayer HealthCare, Leverkusen, Germany, 3 WE Biology, Heinrich-Heine-Universita¨t Du¨sseldorf, Du ¨sseldorf, Germany

Abstract

Background: The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection models. Therefore, a detailed parasitological characterization of a Trichuris muris isolate was performed in C57BL/10 mice. Subsequently, the in vivo efficacies of the aminophenylamidines amidantel, deacylated amidantel (dAMD) and tribendimidine as well as the cyclooctadepsipeptides emodepside and in particular PF1022A were analyzed. This was performed using various administration routes and treatment schemes targeting histotropic and further developed larval as well as immature and mature adult stages.

Methodology/Principal Findings: Duration of prepatent period, time-dependent localization of larvae during period of prepatency as well as the duration of patency of the infection were determined before drugs were tested in the characterized trichurosis model. Amidantel showed no effect against mature adult T. muris . Tribendimidine showed significantly higher potency than dAMD after oral treatments (ED50 values of 6.5 . 15.1 mg/kg). However, the opposite was found for intraperitoneal treatments (ED50 values of 15.3 vs. 8.3 mg/kg). When emodepside and PF1022A were compared, the latter was significantly less effective against mature adults following intraperitoneal (ED50 values of 6.1 vs. 55.7 mg/kg) or subcutaneous (ED 50 values of 15.2 vs. 225.7 mg/kg) administration. Only minimal differences were observed following oral administration (ED50 values of 2.7 vs. 5.2 mg/kg). Triple and most single oral doses with moderate to high dosages of PF1022A showed complete efficacy against histotropic second stage larvae (3 6100 mg/kg or 1 6250 mg/kg), further developed larvae (3 610 mg/kg or 1 6100 mg/kg) and immature adults (3 610 mg/kg or 1 6100 mg/kg). Histotropic first stage larvae were only eliminated after three doses of PF1022A (3 6100 mg/kg) but not after a single dose.

Conclusions/Significance: These results indicate that the cyclooctadepsipeptides are a drug class with promising candidates for further evaluation for the treatment of trichurosis of humans and livestock animals in single dose regimens.

Citation: Kulke D, Kru¨cken J, Harder A, von Samson-Himmelstjerna G (2014) Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice. PLoS Negl Trop Dis 8(2): e2698. doi:10.1371/ journal.pntd.0002698 Editor: Charles D. Mackenzie, Michigan State University, United States of America Received July 17, 2013; Accepted January 2, 2014; Published February 20, 2014 Copyright: ß 2014 Kulke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The present study was performed as a collaborative research project between Bayer HealthCare and the Institute of Parasitology and Tropical Veterinary Medicine, Freie Universita¨t Berlin. Accordingly, the Institute of Parasitology and Tropical Veterinary Medicine, Freie Universita¨t Berlin received a project specific research grant from Bayer HealthCare AG. The funders, except for Achim Harder and Daniel Kulke, had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Daniel Kulke, PhD student of the Institute of Parasitology and Tropical Veterinary Medicine, Freie Universita¨t Berlin, is employed by Bayer HealthCare, Global Drug Discovery, Animal Health, developing veterinary pharmaceuticals including dewormers. Furthermore, Achim Harder was an employee of Bayer HealthCare when the study was conducted. Except of Achim Harder and Daniel Kulke, Bayer HealthCare was not involved in study design, data collection, data analysis or preparation of the manuscript. The decision to publish the manuscript was jointly taken. This does not alter our adherence to all PLOS policies on sharing data and materials. * E-mail: [email protected]

Introduction infected with one or more worm species [2]. An important part of human helminth infections worldwide is caused by soil-transmitted About 20 major human helminthoses have a significant impact nematodes, including the roundworm Ascaris lumbricoides with 800 on global public health [1]. Since a highly disproportionate share million infections, the whipworm Trichuris trichiura with 600 million of the burden occurs in developing areas of sub-Saharan Africa, infections, and the hookworms Ancylostoma duodenale and Necator Asia and the Americas, helminth infections belong to both, the americanus with 600 million infections [4]. An estimated 1.6–6.4 ‘‘neglected tropical diseases’’ and the ‘‘neglected infections of million disability adjusted loss of life years are a direct result of poverty’’ [2,3]. In these regions more than a billion people are trichurosis [4]. In 2010 an estimated 5023 million people lived in

PLOS Neglected Tropical Diseases | www.plosntds.org 1 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

Author Summary parasitosis of clinical relevance and is also suspected to be zoonotic [12]. However, several anthelmintics registered for use in dogs Treatment options against whipworm infections of hu- such as diethylcarbamazine, piperazine, ivermectin and pyrantel mans and livestock are very limited and even anthelmintics lack efficacy against T. vulpis severely limiting the choice of drug recently introduced into the market do not significantly for deworming [12]. In swine, infections with Trichuris suis, the improve the situation. Here, we evaluated members of two dose-limiting nematode for all relevant anthelmintic drug classes, relatively new drug classes, the aminophenylamidines lead to reduced growth rates and therefore result in significant (amidantel, deacylated amidantel, tribendimidine) and economic losses [13]. Finally, due to the long period of prepatency the cyclooctadepsipeptides (PF1022A, emodepside) in a of Trichuris spp. and the lack of efficacy of most drugs against murine trichurosis model. While tribendimidine is licensed histotropic larval forms, two blocks with one to three doses each for the treatment of human helminthosis caused by are usually necessary to completely eliminate the parasites [12]. hookworms, pinworms and roundworms in China, emo- It is therefore obvious, that the development of new, safe and depside is the nematocidal component of dewormers for cats and dogs. With the exception of amidantel, all drugs highly efficacious drugs to treat soil-transmitted nematode showed good efficacies against adult whipworms using infections is urgently required. In particular, new drugs for the three consecutive doses. Due to considerations regarding treatment of Trichuris spp. using a single dose would significantly drug safety and price, PF1022A was further evaluated increase treatment options in both, human and veterinary against histotropic first and second stage larvae, further medicine. Therefore, the evaluation of the efficacy of promising developed larvae, immature and mature adults using a drug candidates against whipworms is an essential step towards single or three consecutive doses. Three doses eliminated improvement of anthelmintic treatment opportunities. all stages while a single dose was inefficient against To investigate and compare the anthelmintic profiles of new histotropic first stage larvae. In general, higher doses were drug candidates against whipworm infections, the Trichuris muris required for early stages in comparison to stages protrud- mouse model is highly suitable [14]. Trichuris L1 hatch in the small ing into the gut lumen. Since only a very basic formulation intestine of their host and migrate rapidly to the caecum and colon of drugs was tested, further improvement can be expected [15], where they invade the epithelium [16] and undergo a from optimized formulations. Cyclooctadepsipeptides histotropic phase with two molts lasting several days (duration should therefore be considered as candidates for evalua- depends on the particular species and isolate). Then, larvae Trichuris tion to treat spp. infections in livestock and migrate to the surface of the epithelium extruding their caudal humans. ends freely into the lumen of the intestine (further developed larvae or free larvae) [16]. In general anthelmintics have been reported to areas stable for transmission of Trichuris trichiura, plus another 284 be less effective against histotropic larvae, which might be million lived in areas of unstable transmission of whipworms, attributed to the poor accessibility of drugs to these larvae within globally [5]. High prevalence often comes along with high the tissue [12]. abundance of energy malnutrition and anemia as well as In order to eliminate parasites using a single dose or at least a limited access to medical care and educational opportunities [6]. single treatment block, it is desirable to evaluate drug candidates Mild T. trichiura infections are often asymptomatic, but severe and not only against mature adult worms but also against histotropic chronic infections can result in the Trichuris dysentery syndrome larvae and further developed immature stages. Since duration of including chronic inflammation of the intestine, rectal prolapse, development and timespan of infection depend on both, the host anemia, poor growth, and clubbing of the fingers [6]. strain [17] and whipworm isolate [18], a detailed characterization Despite the strong impact of helminthoses on public health, only of the respective host-parasite relationship is essential. Thus, four anthelmintics (albendazole, mebendazole, levamisole, and localization of larvae in the course of the prepatent period and pyrantel) with only two different modes of action are listed on the onset of patency of the infection have to be analyzed carefully WHO list of essential medicines to treat soil-transmitted nematode before in vivo assays against specific stages of T. muris can be infections [7] with mebendazole and albendazole being by far the conducted meaningfully with the respective isolate. most commonly used drugs [8]. Whereas both drugs are highly The cyclooctadepsipeptides [19] and the aminophenylamidines effective against adult A. lumbricoides in a single dose, only [20] are promising anthelmintic classes for further development of albendazole is used for the treatment against tissue migrating broad-spectrum drugs to treat intestinal nematode infections. The larvae – mebendazole is poorly absorbed from the gastrointestinal semi-synthetic cyclooctadepsipeptide emodepside has been shown tract thus its therapeutic activity is largely confined to adult/ to have an almost complete efficacy against immature and mature luminal worms [8]. Furthermore, the efficacy of both drugs is stages of T. vulpis in dogs [21] and T. muris in mice [22,23] while unsatisfactory against hookworms and T. trichiura in single dose the aminophenylamidines amidantel and tribendimidine showed regimen [9]. Higher efficacies against whipworms and hookworms only low to moderate efficacy against T. muris in mice [24] and T. were observed when albendazole or mebendazole were adminis- trichiura in humans [25–27]. tered using multiple drug administration [10]. However, treat- Both drug classes have completely different target molecules. It ments using multiple doses significantly increase costs and is clear that the aminophenylamidines are agonists of acetylcholine management efforts in particular in poor communities lacking receptors and have a very similar mode of action as levamisole efficient public health infrastructure. Moreover, persistent under- [28,29] whereas several targets have been suggested for the dosing of A. duodenale , N. americanus and T. trichiura within recently cyclooctadepsipeptides with the voltage-gated, calcium-activated increased large-scaled mass drug administration campaigns against potassium channel SLO-1 as most important candidate filariosis and soil-transmitted helminthosis may favor selection of [19,30,31]. However, the G-protein coupled receptor LAT-1 highly resistant genotypes [9] as already described for T. trichiura [32] and ionotropic GABAA receptors [33,34] might also [11]. contribute to susceptibility to cyclooctadepsipeptides. In addition to its relevance in human medicine, the genus Therefore, the present study investigated and compared the in Trichuris also has an enormous impact on veterinary medicine. For vivo anthelmintic properties of the semi-synthetic cyclooctadepsi- instance, Trichuris vulpis, the dog whipworm, causes an intestinal emodepside, its parental natural fermentation product

PLOS Neglected Tropical Diseases | www.plosntds.org 2 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

PF1022A and the aminophenylamidines amidantel, deacylated the feces were separated from remaining debris by filtration amidantel and tribendimidine against T. muris . Since tribendimi- through a 200 mm sieve and collected in a clean 1 l beaker. The dine has previously been reported to have insufficient activity after residues were rinsed with tap water until the filtrate reached a oral administration in humans [25–27], drugs were also admin- volume of 600 ml. After sedimentation for 1 h, the supernatants istered intraperitoneally and subcutaneously. In addition to the (approximately 500 ml) were removed. The sediment was evaluation of adulticidal efficacy, PF1022A was further tested centrifuged at 2,000 6g and room temperature for 10 min. The against histotropic larvae and further developed immature stages pellet was resuspended in 200 ml tap water and centrifuged under of whipworms, using single and three consecutive doses. the same conditions. After another washing step, the pellet was resuspended in 200 ml saturated sodium chloride solution. Then, Materials and Methods samples were centrifuged at 2,000 6g and room temperature for 5 min, the top 25 ml were filled into a 300-ml beaker and 225 ml 2.1 Ethical statement tap water were added. After at least 2 h of sedimentation the All studies presented were conducted at the laboratories of supernatant was decanted and the sediment was washed in tap Bayer HealthCare, Global Drug Discovery, Animal Health in water another four times. After decanting the supernatant, the Monheim, Germany. The experiments were registered and sediment (approximately 20 ml) was examined for the presence of approved by the State Office for Nature, Environment, Agricul- eggs. Examination of feces was continued until three consecutive ture, and Consumer Protection, North Rhine-Westphalia, Ger- samples were found to be negative. Three independent experi- 1 many (reference number 200/V14), in accordance with 8a, ments with ten mice each were performed. Section 1 and 2 of the German Protection of Animals Act and the 2.4.2 Variation in egg output in the course of patency of European Union directive 2010/63/EU. the infection. To determine the variation in egg output in the course of patency of the infection, a fecal egg count method was 2.2 Drugs adapted from Stoll [35]. In brief, 10 mice were infected. Only Amidantel, dAMD, emodepside and PF1022A were available at animals, positive for eggs in their feces on day 35 p.i., were Bayer HealthCare AG, Global Drug Discovery Animal Health in included in the study. Starting from day 35 p.i., mice were housed Monheim, Germany. Tribendimidine was obtained from Shan- individually on grids in Macrolon cages to collect individual feces dong Xinhua Pharmaceutical Company Limited (Zibo, People’s for 12 h periods once a week. Fecal samples (0.5 g) were weighed Republic of China). All drugs were stored at 4 uC until further use. from each mouse, 7.0 ml water were added and incubated for Individual drug concentrations were prepared separately as 15 min. Feces were roughly macerated with a wooden spatula dispersions in Cremophor EL (BASF, Ludwigshafen, Germany) followed by an extensive homogenization using a magnetic stirrer and deionized-water [1:3] on the days of treatment. at low speed until samples were analyzed. For each sample, three 75 ml aliquots were pipetted on microscope slides and eggs were 2.3 Animals and parasites counted. To obtain the number of eggs per gram feces, the Female SPF inbred mice of the strain C57BL/10 ScSnOlaHsd arithmetic mean of the three counts was multiplied by 200 to (C57BL/10) were purchased from Harlan UK Limited, at four calculate the number of eggs per gram feces (epg). Feces were weeks of age. They were housed in Macrolon cages under analyzed until 15 weeks p.i., since status of patency of the infection environmentally controlled conditions and kept in groups of five became quite variable afterwards (see 2.4.1 and 3.1.1). animals unless otherwise indicated. Water and Sniff rodent food 2.4.3 Time course of localization of larvae in the course of pellets were available ad libitum . Mice were allowed to acclimate for prepatent period. To analyze the time course of the localiza- exactly seven days before starting any experiments. The T. muris tion of larvae during prepatent period the following experiment isolate was kindly provided by Heinz Mehlhorn (Du¨sseldorf, was adapted from Panesar [36]. For this experiment 120 mice Germany). A detailed history regarding isolation and passage is were infected. During the first 40 days p.i., three mice were not available. euthanized daily and their duodena, caeca and colons were Mice were orally infected with a gavage using 0.2 ml fresh tap removed and split open. The luminal content was removed and water with 200 eggs containing fully developed L1 of T. muris . inspected for any stages of T. muris . Then, the mucosa of the guts Murine feces were collected on days 49, 56 and 63 p.i., euthanasia was examined for the presence of worms extruding into the lumen was performed by carbon dioxide suffocation. of the guts. Finally, duodena, caeca and colons were cut into small Isolation of the eggs was performed as described in section 2.4.1. squares and separately incubated in 0.85% physiological sodium The development of L1 in the eggs was performed in stender chloride solution at 37 uC for 24 h. By carefully scraping the dishes in an incubator at 27 uC and 95% humidity for approxi- mucosa the histotropic larvae became visible using a dissecting mately 8 weeks. Progress of embryonation was controlled weekly. microscope. Seven mice, in which not a single stage of T. muris was After development of L1 in .90% of the eggs was completed, eggs found, were excluded from the study. were stored at 4 uC until further usage for a maximum of 6 months. 2.4.4 Female/male ratio in the course of infection. On Before infection of mice, the egg suspension was washed with fresh day 35 p.i., fecal examinations were performed for each of the 60 tap water at room temperature. infected mice individually to confirm patency of the infection. Only animals found positive for eggs in their feces were included in 2.4 Parasitological characterization of a T. muris life cycle the study. Weekly, starting from day 35 until day 152 p.i., three in C57BL/10 mice mice were euthanized and dissected. Female and male whipworms 2.4.1 Determination of the periods of prepatency and in caecum and colon were counted. Two independent experiments patency. To assess the duration of prepatent period, ten mice with 60 mice in each experiment were performed. were infected. Starting from day 7 p.i., all ten mice were housed on 2.4.5 In vitro embryonation of T. muris eggs. The grids to collect feces for 24 h once a week. During these periods, embryonation of eggs was analyzed and compared under several the bottom of the cage was covered with 300 ml tap water. Feces different conditions. Freshly isolated and purified eggs were and water were collected in a 1 l beaker and homogenized with a suspended in (i) 0.5% formaldehyde in physiological sodium hand-held blender. Using a wooden spatula, fine components of chloride solution, (ii) physiological sodium chloride solution or

PLOS Neglected Tropical Diseases | www.plosntds.org 3 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

(iii) tap water and transferred into 40 ml stender dishes (see [37]) to On day 49 p.i., mice were euthanized. Subsequently, necropsy was compare the rate and speed of development. The progress of performed and worms in colons and caeca were counted. embryonation was assessed weekly by microscopic analysis of three 2.5.2 In vivo efficacy against larval and immature adult 10 ml aliquots. Eggs were counted and categorized as (i) stages of T. muris . Based on the parasitological characteriza- unembryonated, (ii) partially embryonated, (iii) fully embryonated tion (duration of prepatent period and time-dependent localization or (iv) degraded. The latter category was chosen according to the of larvae during period of prepatency), the in vivo efficacy of following criteria: a) vesicular appearance of unsegmented eggs or PF1022A was also investigated against larval and immature adult b) deformed larval structures within the eggs. stages of T. muris . According to the time course of localization of Furthermore, incubation temperatures of 4 uC, 19 uC, 27 uC and developmental stages in the present study and the analysis on the 37 uC as well as the influence of the presence of antibiotic (i.e. molting pattern in T. muris [36], the following time points for drug 10 mg/ml sisomycin plus 1 mg/ml clotrimazole), relative humidity administration were chosen: (75%, 85% and 95%) and light conditions (light versus no light) Individual body weight was determined on the day of infection were evaluated in tap water using the same method. for L1, on day 11 p.i. for L2 and on day 25 p.i. for further Finally, the influence of storage at 4 uC after full embryonation developed stages. PF1022A dosages of 10, 100, 250, and 500 mg/ of eggs was compared to storage at 27 uC to determine the best kg or 1.0, 10, 50 and 100 mg/kg were administered on day 3 p.i. storage condition. After embryonation at 27 uC, eggs were stored at or on days 1–3 p.i. to target L1. For the evaluation of efficacy 27 uC or at 4 uC for 70 days. For each incubation temperature, 5 against the histotropic L2, treatments were carried out with mice were infected. On day 45 p.i., mice were euthanized and PF1022A dosages of 10, 100, 250, and 500 mg/kg or 1.0, 10, 50 worm counts were determined. and 100 mg/kg on day 14 p.i. or on days 12–14 p.i., respectively. Since the following molts of males and females are less synchronous 2.5 In vivo efficacy against T. muris in mice [36], treatments were directed against further developed immature In 24 consecutive experimental blocks, 655 mice were stages in general. Treatments with 1.0, 10, 50 and 100 mg/kg randomized into 132 groups, each consisting of five animals. PF1022A were performed on three consecutive days (26–28 p.i.) One group of 5 mice was used for each dosage and for each and treatments with 10, 100, 250, and 500 mg/kg PF1022A only on administration route tested. In each block, 5 infected mice served day 28 p.i. Independently of the targeted stage euthanasia of mice as untreated control and received the vehicle only. and worm counts were performed on day 49 p.i. 2.5.1 In vivo efficacy against mature adult stages of T. muris. On day 42 p.i., a fecal examination was performed for 2.6 Calculation of dose-response curves and statistical each mouse to confirm patency of the infection. Only animals analysis positive for T. muris eggs in their feces were included in the study. For parasitological characterization of the T. muris isolate used Based on the individual body weight on day 45 p.i., exact dosages in C57BL/10 mice, descriptive statistics were performed using were calculated. In case of multiple dose regimens, three doses of GraphPad Prism 5.03. Differences in worm counts between the respective drug were administered orally, intraperitoneally or different weeks of infection and in sex ratio were determined by a subcutaneously (nuchal fold) on days 46–48 p.i. Dosages used are One Way ANOVA followed by Dunnet’s post hoc test using the summarized in Table 1. For single doses, 50, 75, 100, 150, 200, first week of the patent period as the control against which all 250, 300 or 500 mg/kg PF1022A were administered on day 48 p.i. other time points were tested.

Table 1. Single and multiple drug dosages evaluated in vivo against mature adults of T. muris , classified by route of administration.

Dosage(mg/kg) 0.5 1.0 2.5 5.0 7.5 10 15 20 25 50 75 100 150 200 250 300 400 500

PF1022A 3 6oral XXXXX XX X 16 oral XXXXXXX X 36 subcutaneous X XXXXXXX 36 intraperitoneal X XXXXXXX Emodepside 3 6 oral XXXXXX X X 36 subcutaneous X XXXXXXX 36 intraperitoneal X X XXXXX X Amidantel 3 6 oral X 36 subcutaneous 36 intraperitoneal dAMD 3 6 oral X X X XX X 36 subcutaneous X X 36 intraperitoneal X X XX X Tribendimidine 3 6 oral X X X XX X 36 subcutaneous X X 36 intraperitoneal X X XX X

‘X’ indicated that the respective drug was evaluated in the given dose using the indicated route of administration. doi:10.1371/journal.pntd.0002698.t001

PLOS Neglected Tropical Diseases | www.plosntds.org 4 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

For all drugs and routes of administration tested against patent T. muris infections, the reduction of the worm burden expressed in percent of the corresponding control groups of 5 mice was plotted against the log10 of the drug dosages. Efficacies were set to zero if mean of the worm counts was higher than the mean of the corresponding control group. Furthermore, the corresponding SEM values of the affected groups start from 0 (all figures showing dose- response curves). Four-parameter-logistic curves were fitted using GraphPad Prism 5.03 [38]. The top was constrained to values between 0 and 100%. The no-drug controls were set to 24 10 mg/kg to allow log 10 transformation of dosages. Calculated ED 50 and ED 95 values were compared using the extra sum of squares F test. If multiple tests were performed, p values were corrected using the Bonferroni-Holmes procedure. The absolute number of recovered mature adult worms after treatment against larval and immature adult stages was compared to the number of worms isolated from the negative controls by using the non-parametric Kruskal-Wallis test with Dunn’s post hoc test for identification of significant differences between individual groups. Figure 1. Analysis on egg shedding in the course of patency of Results the infection. The graph shows the arithmetic mean values with standard deviations of the absolute numbers of eggs per gram feces 3.1 Time course of T. muris development in C57BL/10 between days 35 and 105 p.i. with a group size of nine animals. Due to the death of one mouse, group size was reduced to eight starting from mice day 70 p.i. 3.1.1 Periods of prepatency and patency of the doi:10.1371/journal.pntd.0002698.g001 infection. In each of the three independent experiments determining presence of eggs in feces in weekly intervals, first duodenum, caecum and colon. After day 5 p.i. no embryonated eggs were found on day 35 p.i. Therefore, prepatent period lasted eggs were found in the gastrointestinal tract. Free larvae were for at least four but not longer than five weeks. None of the mice identified in the debris of guts also for a very limited period during that became patent stopped shedding eggs before week 14 p.i. the first days after infection. Whereas 9.066.2 free larvae were However, starting from week 15 p.i., samples were much more recovered between day 1 and day 5 p.i. only one sample on day 8 heterogeneous. Mice in experiment 1 remained patent at least was found positive for two free larvae. However, starting from day until week 16 p.i., whereas animals in experiment 2 stopped shedding eggs in week 15 p.i. In experiment 3, fecal examination was negative in week 16 p.i., but was positive in week 17 p.i., again. Patency of the infection ended in week 18 p.i. 3.1.2 Detailed analysis on egg shedding. Nine out of ten mice were found positive for eggs in their feces on day 35 p.i. Therefore, only a single mouse was excluded from the study. Furthermore, one individual mouse died on day 67 p.i. and was only included in the statistics until day 63 p.i. Variation in egg shedding in the course of patency of the infection is summarized in Figure 1. Strong variation in individual egg counts was observed, indicated by the relatively large standard deviations (Figure 1). In general, the mean eggs per gram feces (epg) increased during the first three weeks of patency of the infection starting with a mean epg of 2919 61182 (range 800–5600) at day 35 p.i. The peak in egg output was observed in week 8 p.i. (epg = 12200 63813, range 4200–19800). Starting from week 9 p.i., a gradual reduction of the average egg count was observed. In week 14 p.i. the first mouse was found to be negative for eggs in its feces. In another two mice patency of the infection ceased in week 15 p.i. For the remaining five mice the mean (6 SD) of eggs per gram feces was calculated to be 1120 61110.5 (range 200–3600) on week 15 p.i., being the final week of this analysis. Figure 2. Analysis on the occurrence of specific stages of T. muris in the course of the period of prepatency. Presented is the 3.1.3 Localization of developmental stages throughout occurrence of first stage larvae in the luminal content of the guts (free infection. The analysis of the time course of the migration of T. stages), of histotropic first, second and third stage larvae (histotropic muris stages during the period of prepatency revealed distinct stages) and of third and fourth stage larvae as well as immature and phases of localization. Figure 2 summarizes the trend in absolute mature adults attached to the epithelium while extruding their numbers of recovered stages in the course of the prepatent period. posterior parts into the lumen of the guts (extruding stages) between Supplementary Table S1 shows the individual counts divided by days 1 and 31 p.i. Based on dissection of three mice per time point, the graph shows three data points for each stage and time point. If the duodenum, caecum, colon and luminal debris. count was found to be zero for a specific stage in each of the three On days 1–4 p.i. a small number (2.8 61.9, mean 6 SD) of independent counts, data points are not shown. embryonated eggs was recovered from the intestinal debris of doi:10.1371/journal.pntd.0002698.g002

PLOS Neglected Tropical Diseases | www.plosntds.org 5 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

27 an increasing number of immature and mature adult worms in the debris was counted (see Supplementary Table S1). Histotropic larvae were recovered almost throughout the whole evaluation period. However, during the period of prepatency two relative maxima in histotropic larval counts were observed. A high number of histotropic larvae was detected on days 1 and 2 p.i. (45.864.5), while only a small number was recovered between days 3 and 12 p.i. (10.3 64.1). Starting from day 13 the number steadily increased until day 19 p.i., where 50.3 617.4 larvae were counted (see Supplementary Table S1). From day 20 p.i. on, the number of histotropic larvae decreased again and finally, starting from day 24 p.i., the majority of the guts was found to be negative. Further developed stages were not found before day 21 p.i. The number of these stages then increased until day 24 and remained stable (42.6613.9) until the end of the evaluation period (see Figure 2). As expected, neither histotropic larvae nor any further developed stages were found in the duodenum (Supplementary Table S1). On days 30 and 31, the intestinal debris became positive for unembryonated eggs, indicating the start of patency of the infection (Supplementary Table S1). 3.1.4 Worm counts and sex ratio. On day 35 p.i., 107/120 mice harbored a patent infection (infection rate of 89.17%). 13 uninfected mice and 4 mice which had died in the course of the experiment were exclude from the analysis. The absolute worm counts per infected host are summarized in Figure 3A. Mean worm counts were not significantly different from those on day 35 p.i. up to day 70 p.i. (One Way ANOVA followed by Dunnet’s post hoc test, p .0.05) although a tendency to lower and steadily decreasing mean worm counts was observed already at earlier time-points. Thereafter, mean worm counts were significantly lower than on day 35 (p ,0.01) and a con- tinuous decrease in recovered worms was observed (Figure 3A). On day 112 p.i. only five worms per mouse where recovered on average and finally on days 145 and 152 p.i. only two whipworms were found in one of the necropsied mice. In addition to the absolute worm counts, Figure 3B shows the relative sex Figure 3. Analysis on the occurrence of T. muris in the course of distribution of the worms during the same evaluation period. patency of the infection. (A) Absolute worm counts in the course of The male/female ratio was progressively skewed towards male patency of the infection. The graph shows the arithmetic mean values worms. The ratio was 1:1.27 5 weeks p.i, 1:0.97 9 weeks p.i., and standard deviations of the absolute number of recovered worms 1:0.56 14 weeks p.i., and 1:0.12 17 weeks p.i. Starting in week 9, during time with a group size of six animals per time point. Mean worm the male/female ratio was significantly higher than on day 35 p.i. counts were compared to day 35 p.i. using One-Way-ANOVA followed , T. muris (One Way ANOVA followed by Dunnet’s post hoc test, by Dunnet’s post hoc test. **, p 0.01 vs. day 35. (B) Sex ratio of , in the course of patency of the infection. Graph shows the arithmetic p 0.001). From week 18 on, 100% of the recovered worms means with standard deviations of the recovered male worms were males (see Figure 3B). expressed as percentage of total recovered worms with a group size 3.1.5 Optimized conditions for in vitro embryonation of of six animals per time point. ***, p ,0.001 vs. day 35. T. muris eggs. The influence of different media on the rate and doi:10.1371/journal.pntd.0002698.g003 speed of embryonation were compared. No significant difference was observed between (i) 0.5% formaldehyde in physiological sodium chloride solution, (ii) physiological sodium chloride differ significantly, as illustrated by worm counts ranging between solution and (iii) tap water (data not shown). Therefore, tap water 28 and 45 or 12 and 59 (p = 0.69 using the Mann Whitney U test). was used as medium for the following analyses. The incubation In vivo temperature (4 uC, 19 uC, 27 uC or 37 uC) had an enormous impact 3.2 efficacy of cyclooctadepsipeptides and on both speed and embryonation rate (Supplementary Table S2). aminophenylamidines against T. muris Speed of embryonation steadily increased with temperature. The average number of worms recovered from caecum and However, at 37 uC the absolute number of degenerated eggs was colon from untreated control mice on day 49 was 33.77 615.59. also increased. Additives such as sisomycin plus clotrimazole or Worm counts after treatment against developmental stages were lighting conditions did not influence embryonation and were also determined on day 49 p.i. (see 2.5.2), while four mice died therefore neglected. However, relative humidity (75%, 85% and before evaluation and were, therefore, not included in the 95%) strongly affected the loss of medium by evaporation and statistics. The highest worm count was 80, whereas no worms therefore 95% humidity was chosen for routine purposes. were recovered in two cases. Finally, the influence on storage temperature on egg infectivity 3.2.1 In vivo efficacy of aminophenylamidines against after full embryonation was tested. Mice infected with eggs stored mature adult stages of T. muris . Three oral doses of at 27 uC or at 4 uC for at least 70 days were necropsied on day 45 500 mg/kg of the aminophenylamidine amidantel led to no p.i. The infection levels between both groups were not found to significant reduction of the worm burden. Since three high

PLOS Neglected Tropical Diseases | www.plosntds.org 6 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

consecutive doses, whereas the ED 95 of tribendimidine was approximately four times higher than the ED 95 of dAMD after three intraperitoneal administrations (Table 2). However, three subcutaneous doses with 100 mg/kg or 500 mg/kg of either tribendimidine or dAMD had no effect on worm counts in comparison to the vehicle treated group (data not shown). 3.2.2 In vivo efficacy of cyclooctadepsipeptides against mature adult stages of T. muris . Three oral, intraperitoneal or subcutaneous doses of either emodepside or PF1022A on days 46–48 p.i., resulted in dose-dependent reductions of the T. muris burden. Table 2 summarizes ED 50 and ED 95 values as well as comparisons between them by administration route. By comparing the three routes of administration, oral treatments diminished the worm burden at significantly lower doses than intraperitoneal or subcutaneous administrations (Figure 5A, B, C and Table 2). For emodepside, the ED 50 values for intraperitoneal and subcutaneous treatments were approxi- mately twofold and fivefold higher than for oral treatment (Table 2). The differences for PF1022A were even more pronounced. The ED 50 values for intraperitoneal and subcutane- ous treatments were approximately ten and 43-times higher in comparison to the ED 50 values for the oral treatments. By comparing the ED 50 values of the two cyclooctadepsipep- tides, the results were very diverse depending on the respective route of administration. However, the calculated ED 50 value for PF1022A after three intraperitoneal doses was approximately nine times higher than the ED 50 value of emodepside. A comparison of the two drugs after three subcutaneous doses resulted in an approximately 15-fold higher ED 50 value for PF1022A. Surpris- ingly, the ED 50 value of emodepside using three oral administra- tions was only twofold lower than that of PF1022A. Since the costs of PF1022A are much lower than those of emodepside and the difference between both drugs was only small for oral adminis- tration, a single oral dose against mature adult stages of T. muris was only evaluated for PF1022A. A single oral administration of PF1022A on day 48 p.i. also resulted in dose-dependent reduction of the whipworm burden. A dose-response curve was calculated (Figure 5A) and ED 50 and 2 Figure 4. In vivo dose-response curves of dAMD (blue) and ED 95 values with 95% CI as well as R values are presented in tribendimidine (red) after oral (A) and intraperitoneal (B) Table 2. The ED 50 value for PF1022A using a single oral dose was treatments against mature adults of T. muris . Dose-response approximately 36-fold higher in comparison to the three oral curves show the arithmetic mean values and standard errors of the mean with a group size of five animals per drug and dose. Efficacy was administrations. calculated as relative number of recovered worms compared to the no- 3.2.3 In vivo efficacy of PF1022A against developmental T. muris drug control in percentage. Dosages were log 10 transformed and stages of . Both single and multiple PF1022A doses on logistic regressions were calculated with top values constrained day 28 and days 26–28 resulted in dose-dependent reductions in between 0 and 100%. Efficacies were set to zero if mean of the worm the number of recovered worms (Figure 6A, B and Supplementary counts was higher than the mean of the corresponding control group. Table S3). While a single administration of 10 mg/kg did not Furthermore, the corresponding SEM values of the affected groups start 24 result in any apparent effects, 100 mg/kg or higher dosages from zero. The no-drug controls were set to 10 mg/kg to allow log 10 transformation of dosages. already eliminated the worm burden completely. Three oral doses doi:10.1371/journal.pntd.0002698.g004 of PF1022A against developmental stages on days 26–28 also resulted in nearly complete or complete cure rates starting from 10 mg/kg. Therefore, an approximately 10-fold lower dosage of consecutive doses of amidantel did not reduce worm counts in PF1022A was sufficient to cure the infection with further comparison to the no-drug control, this derivative was not further developed larval stages and immature adult worms with three evaluated in the present study. In contrast to amidantel, both oral doses in comparison to a single dose. and intraperitoneal treatments with either tribendimidine or The efficacy of single and multiple PF1022A doses on day 14 dAMD resulted in dose-dependent reductions of the T. muris and days 12–14 respectively, targeting the histotropic L2, also burden. Dose-response curves for both drugs and both routes of resulted in dose-dependent significant reductions of the worm administration are given in Figure 4. Furthermore, ED 50 and burden (Figure 6C, D and Supplementary Table S3). In particular, ED 95 values with 95% confidence intervals as well as p values from three dosages of 100 mg/kg PF1022A or a single administration of comparisons between the derivatives and R2 values are summa- 250 mg/kg PF1022A were required for complete elimination of rized in Table 2. whipworms. The ED 95 of tribendimidine was found to be approximately In contrast to the efficacy against L2, the effects of PF1022A eight times lower than the ED 95 of dAMD following three oral against L1 were not sufficient in the single dose regimen. While

PLOS Neglected Tropical Diseases | www.plosntds.org 7 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

Table 2. Comparison of the in vivo efficacies of the aminophenylamidines amidantel, dAMD and tribendimidine and the cyclooctadepsipeptides emodepside and PF1022A against patent Trichuris muris infections in mice.

ED 50 with 95%CI ED 95 with 95% CI Drug Admin. (inmg/kg) pvalue a (inmg/kg) pvalue b R2

dAMD 36 oral 15.1 (9.9–22.9) ,0.0001 (vs. 36 tribendimidine oral) 97.3 (28.3–334.2) 0.0007 (vs. 36 tribendimidine oral) 0.8039 36 i.p. 8.3 (7.3–9.5) ,0.0001 (vs. 36 tribendimidine i.p.) 12.8 (10.6–15.4) ,0.0001 (vs. 3 6 tribendimidine i.p.) 0.9349 Tribendimidine 36 oral 6.5 (6.0–7.2) ,0.0001 (vs. 36 dAMD oral) 12.6 (9.9–15.9) 0.0007 (vs. 36 dAMDoral) 0.9447 36 i.p. 15.3 (13.2–17.7) ,0.0001 (vs. 36 dAMD i.p.) 44.8 (30.9–65.0) ,0.0001 (vs. 3 6 dAMDi.p.) 0.9279 Emodepside 36 oral 2.7 (1.9–3.9) 0.0009 (vs. 36 PF1022A oral) 24.5 (8.7–68.8) 0.3684 (vs. 3 6 PF1022A oral) 0.8368 36 i.p. 6.1 (4.8–7.7) ,0.0001 (vs. 36 PF1022A i.p.) 40.0 (18.9–84.5) ,0.0001 (vs. 3 6 PF1022A i.p.) 0.9274 36 s.c. 15.2 (13.0–17.7) ,0.0001 (vs. 36 PF1022A s.c.) 40.7 (24.5–67.4) ,0.0001 (vs. 3 6 PF1022A s.c.) 0.8481 PF1022A 36 oral 5.2 (4.0–6.8) 0.0009 (vs. 36 emodepside oral) 36.5 (14.9–89.8) 0.3684 (vs. 3 6 emodepside oral) 0.8681 36 i.p. 55.7 (44.4–70.0) ,0.0001 (vs. 36 emodepside i.p.) 208.5 (99.2–438.2) ,0.0001 (vs. 3 6 emodepside i.p.) 0.8657 36 s.c. 225.7 (180.2–282.6) ,0.0001 (vs. 36 emodepside s.c.) 515.0 (254.8–1041) ,0.0001 (vs. 3 6 emodepside s.c.) 0.7432 16 oral 186.6 (111.0–313.5) ,0.0001 (vs. 36 PF1022A oral) 686.7 (168.5–2798) ,0.0001 (vs. 3 6 PF1022A oral) 0.6086

2 Presented are the ED 50 and ED 95 values with 95% confidence intervals (CI) and coefficients of determination ( R ) as well as p values, for determination of significant differences. a Significant difference in ED 50 to drug in brackets. b Significant difference in ED 95 to drug in brackets. doi:10.1371/journal.pntd.0002698.t002 three doses of 100 mg/kg PF1022A on days 1–3 p.i. were Due to the long prepatent period of Trichuris spp. and the lack of sufficient to completely cure the mice, a single dose on day 3 p.i., efficacy of most drugs against the histotropic phase of larval forms, using even 500 mg/kg, was not able to significantly reduce worm multiple blocks with one to three doses each are usually necessary burdens (Figure 6E, F and Supplementary Table S3). to completely eliminate the infections [12]. Larvae of several gastrointestinal nematode species penetrate into the pits and Discussion glands of the mucosa (e.g. Haemonchus spp., Ostertagia spp., Teladorsagia spp.) or even penetrate and feed on individual cells The majority of human gastrointestinal nematode infections are (e.g. Trichuris spp., Trichinella spp.) to survive the lethargy associated caused by A. lumbricoides , A. duodenale , N. americanus , Strongyloides. with molting without losing their place in the gut [43]. These stercoralis and T. trichiura [8]. Whereas available drugs are usually histotropic larvae are often difficult to eliminate and require higher highly effective against A. lumbricoides in a single dose regimen, at or repeated doses when compared with luminal or mucosal stages. least multiple dosages of those drugs are required to cure In order to evaluate the effects of drugs against the histotropic hookworm, threadworm and particularly whipworm infections. stages of T. muris , a detailed knowledge of the time course of [9,39]. development within the host is required. Since data in the In addition to the enormous impact on human medicine, the literature are often quite old and differ in many observations, genus Trichuris, like T. suis , is also considered to be a dose-limiting especially regarding the number and the time course of molts (for nematode for most current anthelmintics in a variety of hosts of review see [15]), the isolate used in the present study was subjected veterinary importance [13]. However, treatment options are often to an in-depth parasitological analysis. Furthermore, the course of limited. For example, a large number of drugs (diethylcarbama- infection strongly depends on the respective mouse strain [17] and zine, ivermectin, piperazine, pyrantel) registered to treat nematode T. muris isolate [18], making a detailed characterization even more infections in dogs are lacking sufficient efficacy against T. vulpis crucial. [12]. Among the new anthelmintics that entered the market in the The parasitological data obtained here were in agreement with recent past, especially the cyclooctadepsipeptides [21–23] and findings of Panesar and Croll [16]. They reported, that on day 20 partially the aminophenylamidines [20,24,27] are active against p.i., all larvae were found embedded in the surface epithelium with Trichuris spp., whereas paraherquamide has only poor efficacy [40] their posterior ends extruding into the lumen of the gut. In the and monepantel lacks efficacy [41]. For derquantel, only data present study, this observation was made from day 21 onwards. In describing a high efficacy of the combination with abamectin contrast to Panesar and Croll, we still found a small but significant against Trichuris ovis have been published [42]. However, if these number of histotropic stages until day 29 p.i. However, the period effects are attributed to derquantel, abamectin or only the in which histotropic stages were exclusively present was almost the combination of both needs to be clarified. same. Interestingly, observations by Pike [37] were also in line Persistent underdosing of Trichuris spp. in both humans (during with data shown here. They have shown, that the female/male the reinforced mass drug administration campaigns against ratio steadily develops towards more male worms and that male T. lymphatic filariasis and soil-transmitted nematodes) and animals muris survive longer than females, which is in marked contrast to of veterinary importance may favor selection of highly resistant other parasitic nematode species, where females survive longer genotypes [9] as already described for T. trichiura [11]. Therefore, than males [37]. the urgent need for new drugs for the treatment against Trichuris In the present study, no in vivo efficacy of the aminophenyla- spp., preferably in a single dose regimen, is obvious for both midine amidantel was found against patent T. muris infections in human and veterinary medicine. mice. Three oral doses of 500 mg/kg amidantel did not reduce the

PLOS Neglected Tropical Diseases | www.plosntds.org 8 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

mean of the worm counts was higher than the mean of the corresponding control group. Furthermore, the corresponding SEM values of the affected groups start from zero. The no-drug controls were 24 set to 10 mg/kg to allow log 10 transformation of dosages. doi:10.1371/journal.pntd.0002698.g005 worm burden in comparison to the no-drug control. The efficacy of amidantel against T. muris was investigated previously and was also found to be only moderate [24]. Therefore, amidantel was not further evaluated in the presented study. In contrast, three consecutive oral doses with either tribendimidine or dAMD resulted in ED 50 values of 6.5 mg/kg and 15.1 mg/kg, respec- tively. Complete elimination of the worm burden was achieved by three oral doses using either 25 mg/kg tribendimidine or 100 mg/ kg dAMD. Oral doses of 1 6400 mg [44] or 3 6400 mg [26] tribendimidine have been shown to result in cure rates of 76.8% and 33.3%, respectively, against T. trichiura in humans. Intraper- itoneal injections of the drugs, which to our knowledge were evaluated for the first time, resulted in reversed potency with ED 50 values of 15.3 mg/kg for tribendimidine and 8.3 mg/kg for dAMD and complete elimination at dosages above 50 mg/kg in both cases. This is somewhat surprising since tribendimidine is known to rapidly disintegrate in aqueous environments releasing two molecules of dAMD [45]. Differences in release of the highly hydrophobic drugs from the used formulation (dispersion containing Cremophor EL/deionized water) are the most likely explanation for the observed phenomenon. The larger tribendi- midine molecule can be suspected to diffuse more slowly into the aqueous environment. It can be assumed that release of drugs from the dispersion occurs more rapidly in the digestive track under mechanical mixing in the presence of bile salts than in the peritoneum and that passive diffusion is of minor importance in the gut. The absence of efficacy of tribendimidine and dAMD using subcutaneous administrations might also be due to the very basic formulation of the drugs. However, neither intraperitoneal nor subcutaneous administrations, using such a basic formulation, were able to significantly improve the efficacy of tribendimidine or dAMD against T. muris in mice. In contrast to the aminophenylamidines, the cyclooctadepsipep- tide, emodepside, has previously been shown to be completely effective against T. vulpis [21] and also T. muris [22,23]. A single dosage of 7.16 mg/kg emodepside in the Profender spot on formulation for cats was sufficient to clear patent T. muris infections of mice within 48 h [22] and even treatments of mice against immature stages using 6.0 mg/kg emodespide of the same formulation on day 3, day 20 or day 35 p.i., resulted in significantly reduced worm counts (.95% efficacy) [23]. Next to the oral tablet formulation of Profender for dogs with 1 mg/kg emodepside [21], also a single dose of 0.45 mg/kg emodepside of the oral Procox suspension was sufficient to completely eliminate immature and mature T. vulpis from dogs [46]. However, almost all investigations on the efficacy and safety of emodepside were conducted on nematodes of veterinary importance and only few in vitro data on important nematodes of humans are available [47], and PF1022A has not been evaluated against Trichuris spp. at all. Figure 5. In vivo dose-response curves of emodepside (red) and However, while no clinical signs of intolerability were found, a PF1022A (blue) after oral (A), intraperitoneal (B) or subcuta- high degree of efficacy against a large number of helminths in a neous (C) treatments against mature adults of T. muris . Dose- response curves show the arithmetic mean values with standard errors variety of hosts including Heligmosomoides bakeri in mice [48], of the mean with a group size of five animals per drug and dose. Strongyloides ratti and Nippostrongylus brasiliensis in rats, Ancylostoma Efficacy was calculated as relative number of recovered worms caninum in dogs, cyathostomes in horses, Trichostrongylus colubriformis compared to the no-drug control in percentage. Dosages were log 10 and Haemonchus contortus in sheep and Dictyocaulus viviparus in cattle transformed and logistic regressions were calculated with top values using fairly low dosages of 1–10 mg/kg PF1022A were reported constrained between 0 and 100%. Triangles indicate a single dose of [49]. PF1022A (light blue), circles three doses of PF1022A (dark blue) and squares three doses of emodepside (red). Efficacies were set to zero if There were also differences in efficacy comparing emodepside and PF1022A in the present study, but the magnitude of these

PLOS Neglected Tropical Diseases | www.plosntds.org 9 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

Figure 6. In vivo efficacy of PF1022A against L3, L4 and immature adults (A, B), histotropic L2 (C, D) and histotropic L1 (E, F) of T. muris using both, single (A, C, E) and triple (B, D, F) dose regimens. Box plots show the median numbers and quartiles of recovered adult T. mu ris after treatment against immature stages with wiskers representing minimal and maximal values. Group sizes were 5 mice per drug and dose. +, arithmetic mean; *, p ,0.01 vs. control; **, p,0.001 vs. control. doi:10.1371/journal.pntd.0002698.g006

differences was dependent on the route of administration. the subcutaneous route. The ED 50 and ED 95 values for PF1022A However, emodepside always performed significantly better than were only 1.9 and 1.5 fold higher than those for emodepside, PF1022A using the ED 50 value as criterion. The difference respectively. between both drugs was particularly small for the oral adminis- For its suitability in mass-drug-treatment programs, drugs need tration, which also performed better than the intraperitoneal and a high safety and production costs should be as low as possible.

PLOS Neglected Tropical Diseases | www.plosntds.org 10 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

Due to the fact that the class of aminophenylamidines is still muris infections of mice within 48 h. In sharp contrast to that, three considered to be potentially hazardous [50] and PF1022A does consecutive oral doses of 75 mg/kg emodepside using the have much cheaper production costs than emodepside (due to Cremophor EL/water dispersion were required to achieve a omission of semi-synthetic derivatization) [47], single dose complete elimination of patent T. muris infections in the present experiments and treatments targeting developmental stages were study. The more than 10-fold increase in efficacy between three only performed with PF1022A. In addition, no data regarding the doses using Cremophor/water and a single dose using the effects of PF1022A on any stages of Trichuris spp. have been optimized Profender formulation emphasizes that every drug published previously. To examine whether PF1022A has the formulation has to be optimized for each drug and host species potential to replace the more expensive emodepside in therapy of and that dramatic decreases in required drug dosages are possible Trichuris spp., it is important to determine the suitability of when using an optimized formulation. In addition, optimization of PF1022A as a broad-spectrum anthelmintic. formulations also decreases the risk of intoxications and the costs At least in the triple dose regimen, PF1022A was able to of treatment, in particular, if drugs can be targeted specifically completely eliminate all developmental stages of T. muris . towards the location of the parasite, e.g., the gut, avoiding high However, the required dosages inversely correlated with the time drug concentrations in tissues, e.g., the brain, which may be span after infection, i.e. the earlier stages had to be treated with important for side effects. higher dosages. Single drug administration needed 2.5 to 10-fold In conclusion, in vivo treatments with relatively high doses of higher dosages to achieve complete resolution of the infections, PF1022A resulted in complete elimination of Trichuris muris, and against L1 larvae no significant effect on worm burdens could including mature adult and immature adult worms as well as be obtained using only a single dose. The most likely reason for histotropic and further developed larval stages in a single-dose this observation is the localization of the larvae. Larvae develop regimen. Since only non-optimized formulations were evaluated in deep in the epithelium of the basal parts of the crypts of this study, considerably lower dosages might be achievable, using Lieberku¨hn until day 5 p.i., while they were found closer to the formulations optimized for particular host species. Despite the fact surface of the epithelium between days 5 and 10 p.i. On day 15 that detailed safety and pharmacokinetic studies are still p.i., a large proportion of histotropic larvae was already found in completely missing for humans, distinct effects of PF1022A against the epithelial surface, where a higher drug concentration might be the usually dose-limiting genus Trichuris in the mouse model present [16]. suggest that cyclooctadepsipeptides are useful candidates for One might think that the relatively high dosages of PF1022A development as agents against human soil-transmitted hel- required to completely eliminate developmental T. muris stages, minthoses and nematode infections of livestock animals. especially in single dose regimens, could prevent its further development as trichuricidal drug. However, potential improve- Supporting Information ment of efficacy through optimized galenic formulations should be taken into account. The potential of cyclooctadepsipeptides for Table S1 Localization of T. muris stages throughout prepatency. efficient treatment against Trichuris spp. has been shown using (PDF) single oral administration of Profender tablets (Bayer Animal Table S2 Temperature dependency of T. muris larval develop- Health GmbH, Leverkusen, Germany). A dose rate of 1 mg/kg ment in eggs. emodepside resulted in almost complete elimination of immature (PDF) and mature stages of T. vulpis in dogs ( .99%) [20], suggesting that optimized formulations can dramatically improve drug perfor- Table S3 Descriptive statistics for each treatment group mance in this drug class. The formulation in Profender tablets is (classified by individual drugs, dose regimen and route of optimized to eliminate all relevant parasitic nematodes of dogs and administration). optimization can be considered to improve drug efficacy. (PDF) Emodepside is also the only nematocidal ingredient of Profender spot-on for cats and Procox suspension for puppies. Although Author Contributions using a different route of administration (dermal) Mehlhorn et al. Conceived and designed the experiments: DK AH GvSH. Performed the [22] have shown that a single dosage of 7.16 mg/kg emodepside in experiments: DK. Analyzed the data: DK JK. Wrote the paper: DK JK the Profender spot on formulation for cats was sufficient to clear T. GvSH.

References 1. Awasthi S, Bundy DA, Savioli L (2003) Helminthic infections. BMJ 327: 431–433. 10. Keiser J, Utzinger J (2010) The drugs we have and the drugs we need against 2. Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, et al. (2012) A major helminth infections. Adv Parasitol 73: 197–230. research agenda for helminth diseases of humans: the problem of helminthiases. 11. Diawara A, Drake LJ, Suswillo RR, Kihara J, Bundy DA, et al. (2009) Assays to PLoS Negl Trop Dis 6: e1582. detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris 3. Knopp S, Steinmann P, Keiser J, Utzinger J (2012) Nematode infections: soil- lumbricoides. PLoS Negl Trop Dis 3: e397. transmitted helminths and trichinella. Infect Dis Clin North Am 26: 341–358. 12. Traversa D (2011) Are we paying too much attention to cardio-pulmonary 4. Hotez PJ, Fenwick A, Savioli L, Molyneux DH (2009) Rescuing the bottom nematodes and neglecting old-fashioned worms like Trichuris vulpis? Parasit billion through control of neglected tropical diseases. Lancet 373: 1570–1575. Vectors 4: 32. 5. Pullan RL, Brooker SJ (2012) The global limits and population at risk of soil- 13. Arends J, Vercruysse J (2002) The use of macrocyclic lactones to control transmitted helminth infections in 2010. Parasit Vectors 5: 81. parasites of pigs. In: Vercruysse J, Rew RS, editors. Macrocyclic lactones in 6. Stephenson LS, Holland CV, Cooper ES (2000) The public health significance antiparasitic therapy. Wallingford, UK and New York, USA: CABI Publishing. of Trichuris trichiura. Parasitology 121 Suppl: S73–95. 14. Keeling JE (1961) Experimental trichuriasis. II. Anthelmintic screening against 7. World Health Organization (2011) WHO model list of essential medicines : 17th Trichuris muris in the albino mouse. J Parasitol 47: 647–651. list, March 2011. Geneva: World Health Organization. 45 p. p. 15. Anderson RC (2000) Nematode parasites of : their development and 8. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, et al. (2006) Soil- transmission. Wallingford, Oxon, UK; New York, NY: CABI Pub. xx, 650 p. p. transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 16. Panesar TS, Croll NA (1980) The location of parasites within their hosts: site 367: 1521–1532. selection by Trichuris muris in the laboratory mouse. Int J Parasitol 10: 261– 9. Prichard RK, Basanez MG, Boatin BA, McCarthy JS, Garcia HH, et al. (2012) 273. A research agenda for helminth diseases of humans: intervention for control and 17. Wakelin D (1967) Acquired immunity to Trichuris muris in the albino elimination. PLoS Negl Trop Dis 6: e1549. laboratory mouse. Parasitology 57: 515–524.

PLOS Neglected Tropical Diseases | www.plosntds.org 11 February 2014 | Volume 8 | Issue 2 | e2698 Evaluation of Drug Candidates against T. muris

18. Johnston CE, Bradley JE, Behnke JM, Matthews KR, Else KJ (2005) Isolates of 33. Chen W, Terada M, Cheng JT (1996) Characterization of subtypes of gamma- Trichuris muris elicit different adaptive immune responses in their murine host. aminobutyric acid receptors in an Ascaris muscle preparation by binding assay Parasite Immunol 27: 69–78. and binding of PF1022A, a new anthelmintic, on the receptors. Parasitol Res 82: 19. Kru¨cken J, Harder A, Jeschke P, Holden-Dye L, O’Connor V, et al. (2012) 97–101. Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action. 34. Miltsch SM, Krucken J, Demeler J, Janssen IJ, Kruger N, et al. (2012) Decreased Trends Parasitol 28: 385–394. emodepside sensitivity in unc-49 gamma-aminobutyric acid (GABA)-receptor- 20. Xiao SH, Utzinger J, Tanner M, Keiser J, Xue J (2013) Advances with the deficient Caenorhabditis elegans. Int J Parasitol 42: 761–770. Chinese anthelminthic drug tribendimidine in clinical trials and laboratory 35. Stoll NR (1923) Investigations on the control of hookworm disease. XV. An investigations. Acta Trop 126: 115–126. effective method of counting hookworm eggs in feces. Am J Epidemiol 3: 59–70. 21. Schimmel A, Altreuther G, Schroeder I, Charles S, Cruthers L, et al. (2009) 36. Panesar TS (1989) The moulting pattern in Trichuris muris (Nematoda: Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) Trichuroidea). Can J Zool 67: 2340–2343. against mature and immature adult Trichuris vulpis infections in dogs. Parasitol 37. Pike EH (1969) Egg output of Trichuris muris (Schrank, 1788). . J Parasitol 55: Res 105 Suppl 1: S17–22. 1046–1049. 22. Mehlhorn H, Schmahl G, Frese M, Mevissen I, Harder A, et al. (2005) Effects of 38. Motulsky H, Christopoulos A (2004) Fitting models to biological data using a combinations of emodepside and praziquantel on parasites of and linear and nonlinear regression : a practical guide to curve fitting. Oxford; New rodents. Parasitol Res 97 Suppl 1: S65–69. York: Oxford University Press. 351 p. p. 23. Schmahl G, Mehlhorn H, Harder A, Klimpel S, Krieger KJ (2007) Efficacy of 39. Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong combination of emodepside plus praziquantel against larval and adult stages of S, et al. (2011) Efficacy and safety of single and double doses of ivermectin versus nematodes (Trichuris muris, Angiostrongylus cantonensis) in rodents. Parasitol 7-day high dose albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis 5: Res 101: 77–84. e1044. 24. Wollweber H, Niemers E, Flucke W, Andrews P, Schulz HP, et al. (1979) 40. Shoop WL, Eary CH, Michael BF, Haines HW, Seward RL (1991) Anthelmintic Amidantel, a potent anthelminthic from a new chemical class. Arzneimittel- activity of paraherquamide in dogs. Vet Parasitol 40: 339–341. forschung 29: 31–32. 41. Tritten L, Silbereisen A, Keiser J (2011) In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal 25. Steinmann P, Zhou XN, Du ZW, Jiang JY, Xiao SH, et al. (2008) nematode infections. PLoS Negl Trop Dis 5: e1457. Tribendimidine and albendazole for treating soil-transmitted helminths, 42. Little PR, Hodge A, Maeder SJ, Wirtherle NC, Nicholas DR, et al. (2011) Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Efficacy of a combined oral formulation of derquantel-abamectin against the Negl Trop Dis 2: e322. adult and larval stages of nematodes in sheep, including anthelmintic-resistant 26. Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005) Tribendimi- strains. Vet Parasitol 181: 180–193. dine: a promising, safe and broad-spectrum anthelmintic agent from China. 43. Sutherland I, Scott I (2010) Gastrointestinal nematodes of sheep and cattle - Acta Trop 94: 1–14. biology and control. Oxford, United Kingdom, Ames, Iowa, United States of 27. Xiao SH, Wu ZX, Zhang JH, Wang SQ, Wang SH, et al. (2007) Clinical America: Blackwell Publishing. observation on 899 children infected with intestinal nematodes and treated with 44. Wu ZX, Fang YY, Liu YS (2006) Effect of a novel drug – enteric coated tribendimidine enteric coated tablets. Chin J Parasit Dis 25: 372–375. tribendimidine in the treatment of intestinal nematode infections. Zhongguo Ji 28. Hu Y, Xiao SH, Aroian RV (2009) The new anthelmintic tribendimidine is an Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 24: 23–26. L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS 45. Yuan G, Xu J, Qu T, Wang B, Zhang R, et al. (2010) and Negl Trop Dis 3: e499. disposition of tribendimidine and its metabolites in healthy Chinese volunteers. 29. Miltsch SM, Krucken J, Demeler J, Ramunke S, Harder A, et al. (2013) Drugs R D 10: 83–90. Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion 46. Petry G, Altreuther G, Wolken S, Swart P, Kok DJ (2013) Efficacy of channel mutants. Parasitol Int 62: 591–8. emodepside plus toltrazuril oral suspension for dogs (Procox(R), Bayer) against 30. Welz C, Kruger N, Schniederjans M, Miltsch SM, Krucken J, et al. (2011) SLO- Trichuris vulpis in naturally infected dogs. Parasitol Res 112 Suppl 1: 133–138. 1-channels of parasitic nematodes reconstitute locomotor behaviour and 47. Olliaro P, Seiler J, Kuesel A, Horton J, Clark JN, et al. (2011) Potential drug emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. development candidates for human soil-transmitted helminthiases. PLoS Negl PLoS Pathog 7: e1001330. Trop Dis 5: e1138. 31. Guest M, Bull K, Walker RJ, Amliwala K, O’Connor V, et al. (2007) The 48. Nwosu U, Vargas M, Harder A, Keiser J (2011) Efficacy of the cyclooctadepsi- calcium-activated potassium channel, SLO-1, is required for the action of the peptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis Parasitology 138: 1193–1201. elegans. Int J Parasitol 37: 1577–1588. 49. von Samson-Himmelstjerna G, Harder A, Schnieder T, Kalbe J, Mencke N 32. Saeger B, Schmitt-Wrede HP, Dehnhardt M, Benten WP, Krucken J, et al. (2000) In vivo activities of the new anthelmintic depsipeptide PF 1022A. (2001) -like receptor from the parasitic nematode Haemonchus Parasitol Res 86: 194–199. contortus as target for the anthelmintic depsipeptide PF1022A. FASEB J 15: 50. Epe C, Kaminsky R (2013) New advancement in anthelmintic drugs in 1332–1334. veterinary medicine. Trends Parasitol 29: 129–134.

PLOS Neglected Tropical Diseases | www.plosntds.org 12 February 2014 | Volume 8 | Issue 2 | e2698