Unnatural Amino Acids Mir027 a Market Insight Report– July 2010

Total Page:16

File Type:pdf, Size:1020Kb

Unnatural Amino Acids Mir027 a Market Insight Report– July 2010 UNNATURAL AMINO ACIDS MIR027 A MARKET INSIGHT REPORT– JULY 2010 CONTENTS 1. SCOPE AND METHODOLOGY .......................................................................................................................... 1 2. REPORT SYNOPSIS ......................................................................................................................................... 4 Unnatural Amino Acids – An Introduction ............................................................................................................................. 4 Amino Acids ........................................................................................................................................................................... 5 Types of Amino Acids ......................................................................................................................................................... 6 Essential Amino Acids ..................................................................................................................................................... 6 Non‐Essential Amino Acids ............................................................................................................................................. 6 Proteinogenic Amino Acids ............................................................................................................................................ 6 Non‐Proteinogenic Amino Acids..................................................................................................................................... 6 Non‐Standard Amino Acids ............................................................................................................................................ 6 Synthetic Unnatural Amino Acids ................................................................................................................................... 7 Amino Acids Analogs ................................................................................................................................................... 7 Tyrosine Analogs .................................................................................................................................................... 7 Glutamine Analogs ................................................................................................................................................. 7 Phenylalanine Analogs ........................................................................................................................................... 7 Synthesis Applications of Amino Acids ........................................................................................................................... 7 Use of Optically Pure Amino Acids ................................................................................................................................. 8 Segmentation of Unnatural Amino Acids .............................................................................................................................. 9 Exhibit 1: Segmentation of Unnatural Amino Acids Market by Type and Application ................................................ 9 Unnatural Amino Acids ‐ Definitions, Important Facts & Figures ....................................................................................... 9 β‐Amino Acids & Derivatives ....................................................................................................................................... 9 β‐Amino acids ......................................................................................................................................................... 9 β‐Alanine ................................................................................................................................................................ 9 β‐Methylphenylalanine ........................................................................................................................................ 10 β‐Amino Alcohols ................................................................................................................................................. 11 Cyclic Amino Acids & Derivatives .............................................................................................................................. 11 Cyclic β‐Amino Acids ............................................................................................................................................ 11 Cyclic Unnatural α‐Amino Acids ........................................................................................................................... 11 D‐Cycloserine ........................................................................................................................................................ 11 D‐Amino Acids & Derivatives .................................................................................................................................... 12 D‐Phenylglycine .................................................................................................................................................... 13 D‐Cysteine ............................................................................................................................................................ 14 D‐Serine ................................................................................................................................................................ 15 D‐Proline ............................................................................................................................................................... 16 D‐Valine ................................................................................................................................................................ 17 D‐Alanine .............................................................................................................................................................. 18 D‐Phenylalanine ................................................................................................................................................... 19 D‐Citrulline /D‐Citrulene ....................................................................................................................................... 21 D‐Tryptophan ....................................................................................................................................................... 21 MIR027‐Unnatural Amino Acids – A Market Insight Report, July 2010 © RI Technologies, www.researchimpact.com ‐ i ‐ UNNATURAL AMINO ACIDS MIR027 A MARKET INSIGHT REPORT– JULY 2010 CONTENTS D‐Lysine ................................................................................................................................................................ 23 D‐Leucine .............................................................................................................................................................. 23 D‐Histidine ............................................................................................................................................................ 24 D‐Glutamic Acid .................................................................................................................................................... 25 D‐Methionine ....................................................................................................................................................... 26 D‐Aspartic Acid ..................................................................................................................................................... 27 D‐Tyrosine ............................................................................................................................................................ 28 D‐Arginine ............................................................................................................................................................ 30 D‐p‐Hydroxyphenylglycine ................................................................................................................................... 30 D‐Penicillamine ..................................................................................................................................................... 31 DL‐Amino Acids & Derivatives ................................................................................................................................... 32 DL‐Alanine ............................................................................................................................................................ 32 DL‐Methionine...................................................................................................................................................... 33 DL‐Phenylalanine .................................................................................................................................................. 34 L‐Amino Acid Derivatives .......................................................................................................................................... 35 L‐Homophenylalanine .......................................................................................................................................... 35 L‐Dopa .................................................................................................................................................................
Recommended publications
  • Oral Presentations September 23Rd - Rooms 1,2 and 3
    Oral Presentations September 23rd - Rooms 1,2 and 3 Presentation Date Abstract Authors Presenter´s name - Theme Title Code indicated by the author 18498 Thomas Smits; Femke Gresnigt; Thomas Smits Clinical Toxicology/drugs of PERFORMANCE OF AN IMMUNOASSAY Eric Franssen; Milly Attema-de abuse METHOD FOR GAMMA-HYDROXYBUTYRIC Jonge ACID (GHB) IN PATIENTS PRESENTED AT THE EMERGENCY DEPARTMENT, A PROSPECTIVE STUDY 18499 Thomas Smits; Femke Gresnigt; Thomas Smits Clinical Toxicology/drugs of DO WE NEED POINT-OF-CARE TESTING OF Milly Attema-de Jonge; Eric abuse GAMMA-HYDROXYBUTYRIC ACID (GHB) AT Fransse THE EMERGENCY DEPARTMENT? September 23 18730 Lilian H.J. Richter; Julia Menges; Lea Wagmann Clinical Toxicology/drugs of NEW PSYCHOACTIVE SUBSTANCES: Lea Wagmann; Simon D. Brandt; abuse METABOLIC FATE, ISOZYME-MAPPING, 13:30 - 14:45 Folker Westphal; Veit Flockerzi; AND PLASMA PROTEIN BINDING OF 5-APB- ROOM 1 Markus R. Meyer NBOME, 2C-B-FLY-NB2ETO5CL, AND 2C-B- FLY-NBOME 18985 Annelies Cannaert; Marie Annelies Cannaert Clinical Toxicology/drugs of HIDE AND SEEK: OVERCOMING THE Deventer; Melissa Fogarty; abuse MASKING EFFECT OF OPIOID Amanda L.A. Mohr; Christophe P. ANTAGONISTS IN ACTIVITY-BASED Stove SCREENING TESTS 18740 Souleiman El Balkhi ; Roland Souleiman El Balkhi Clinical Toxicology/drugs of METABOLIC INTERACTIONS BETWEEN Lawson; Franck Saint-Marcoux abuse OXYCODONE, BENZODIAZEPINES OR DESIGNER BENZODIAZEPINES PLAY AN IMPORTANT ROLE IN OXYCODONE INTOXICATIONS 19050 Brenda de Winter F de Velde; MN Brenda de Winter Anti-infective drugs POPULATION
    [Show full text]
  • Critical Access COVID-19 Drugs Shortages (156-40)
    Resilient Drug Supply Project: Critical Acute Drug List & Critical COVID-19 Drug List Drug Shortages Reported by ASHP & FDA Shortages as of 8/22/2021 UMN RDSP UMN RDSP ASHP FDA Drug Critical Acute Drugs Drug Category List of 156 List of 40 Drug Drug # Generic Name Critical Acute Critical Shortage Shortage Drugs COVID-19 List List Drugs 1 Cisatracurium Paralytic X X Yes 2 Rocuronium Paralytic X X Yes 3 Vecuronium Paralytic X X Yes Yes 4 Succinylcholine Paralytic X X 5 Atracurium Paralytic X 6 Propofol Sedation X X Yes Yes 7 Midazolam Sedation X X Yes Yes 8 Lorazepam Sedation X X Yes Yes 9 Dexmedetomidine Sedation/Anesthesia X X Yes Yes 10 Phenobarbital Sedation X 11 Ketamine Sedation/Anesthesia X X Yes Yes 12 Diazepam Sedation X 13 Lidocaine Local Anesthetic X Yes Yes 14 Bupivacaine Local Anesthetic X Yes Yes 15 Fentanyl Pain X X Yes Yes 16 Hydromorphone Pain X X Yes Yes 17 Morphine Pain X X Yes Yes 18 Oxycodone Pain X X 19 Acetaminophen Pain & Fever X 20 Ketorolac Pain X Yes Yes 21 Anakinra Pain X 22 Oxygen Medical Gas X X 23 Nitric Oxide Medical Gas X 24 Sevoflurane Medical Gas X 25 Albuterol Bronchodilator X X Yes 26 Ipratropium (Inhaler) Bronchodilator X 27 Azithromycin Anti-infective X X 28 Piperacillin-Tazobactam Anti-infective X X 29 Cefepime Anti-infective X X Yes 30 Ceftriaxone Anti-infective X 31 Vancomycin Anti-infective X X Yes 32 Doxycycline Anti-infective X 33 Meropenem Anti-infective X X 34 Cefazolin Anti-infective X X Yes Yes 35 Levofloxacin Anti-infective X 36 Linezolid Anti-infective X 37 Ampicillin-Sulbactam Anti-infective
    [Show full text]
  • Genscript Product Catalog 2013-2014 Genscript Product Catalog
    GenScript Product Catalog 2013-2014 GenScript Product Catalog www.genscript.com GenScript USA Inc. 860 Centennial Ave. Piscataway, NJ 08854USA Tel: 1-732-885-9188 / 1-732-885-9688 Toll-Free Tel: 1-877-436-7274 Fax: 1-732-210-0262 / 1-732-885-5878 Email: [email protected] Nucleic Acid Purification and Analysis Business Development Tel: 1-732-317-5088 PCR PCR and Cloning Email: [email protected] Protein Analysis Antibodies 2013-2014 Peptides Welcome to GenScript GenScript USA Incorporation, founded in 2002, is a fast-growing biotechnology company and contract research organization (CRO) specialized in custom services and consumable products for academic and pharmaceutical research. Built on our assembly-line mode, one-stop solutions, continuous improvement, and stringent IP protection, GenScript provides a comprehensive portfolio of products and services at the most competitive prices in the industry to meet your research needs every day. Over the years, GenScript’s scientists have developed many innovative technologies that allow us to maintain our position at the cutting edge of biological and medical research while offering cost-effective solutions for customers to accelerate their research. Our advanced expertise includes proprietary technology for custom gene synthesis, OptimumGeneTM codon optimization technology, CloneEZ® seamless cloning technology, FlexPeptideTM technology for custom peptide synthesis, BacPowerTM technology for protein expression and purification, T-MaxTM adjuvant and advanced nanotechnology for custom antibody production, as well as our ONE-HOUR WesternTM detection system and eStain® protein staining system. GenScript offers a broad range of reagents, optimized kits, and system solutions to help you unravel the mysteries of biology. We also provide a comprehensive portfolio of customized services that include Bio-Reagent, Bio-Assay, Lead Optimization, and Antibody Drug Development which can be effectively integrated into your value chain and your operations.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,353,350 B2 Kobayashi Et Al
    US009353350B2 (12) United States Patent (10) Patent No.: US 9,353,350 B2 Kobayashi et al. (45) Date of Patent: May 31, 2016 (54) METHOD FOR PRODUCING MULTIPOLAR 2012fO149053 A1 6, 2012 Yoshida et al. CELL 2013,0323,776 A1 12/2013 Yoshida et al. 2015. OO18286 A1* 1/2015 Kobayashi et al. .......... 514, 19.3 (71) Applicant: TOAGOSEICO.,LTD., Tokyo (JP) FOREIGN PATENT DOCUMENTS (72) Inventors: Nahoko Kobayashi, Tsukuba (JP); CN 1763O82 A 4/2006 Tetsuhiko Yoshida, Tsukuba (JP); Yuki DE 102009021681 A1 11, 2010 Kobayashi, Fujisawa (JP) WO O3O24408 A2 3, 2003 WO O3O37172 A2 5, 2003 WO 2004.005472 A2 1, 2004 (73) Assignee: TOAGOSEICO. LTD., Tokyo (JP) WO 2004/020457 A2 3, 2004 WO 2007/004869 A2 1, 2007 (*) Notice: Subject to any disclaimer, the term of this WO 2007056188 A1 5/2007 patent is extended or adjusted under 35 WO 2008/081812 A1 T 2008 WO WO 2009,093692 A1 T 2009 U.S.C. 154(b) by 0 days. WO WO 2011/O13698 A1 2, 2011 (21) Appl. No.: 14/366,971 WO WO 2011/O13699 A1 2, 2011 (22) PCT Filed: Dec. 20, 2012 OTHER PUBLICATIONS Paradis-Bleau et al., “Peptide inhibitors of the essential cell division (86). PCT No.: PCT/UP2O12AO83110 protein FtsA'. Protein Engineering, Design & Selection, 2005, pp. S371 (c)(1), 85-91, vol. 18, No. 2, Oxford University Press. (2) Date: Jun. 19, 2014 Paradis-Bleau et al., “Identification of Pseudomonas aeruginosa FtsZ. peptide inhibitors as a tool for development of novel antimicro bials”, Journal of Antimicrobial Chemotherapy, Jun. 2004, pp.
    [Show full text]
  • Subject Index to Abstracts
    003 1-3998/84/1804-429ASO2.00 PEDIATRIC RESEARCH Vol. 18 No. 4, 1984 Copyright 0 1984 International Pediatric Research Foundation, Inc. Prinled in U.S.A. Subject Index to Abstracts Abortion 767 Adenosine 2 15, 389 Aminoglycoside 342, 1140 Arachidonic acid 295, 925, 1125, Absorption, gastrointestinal 7 15 Adenosine deaminase deficiency Aminonucleoside nephrosis 1598 1 139, 1254 Absorption, passive 706 888 Aminophylline 137 1, 1853 Arginine 134 1 Abstinence 140 1 Adenosine triphosphate 839 Aminopyrine 388 Arginine vasopressin 234,235,249 Abuse 24, 28, 37, 105 Adenovirus 542, 1044, 1073, 1133 Ammonia 1 397, 1707 Argininosuccinicaciduria 78 1 Abuse, sexual 1085 Adenylate kinase 1648 Amnesia 825 Argininosuccinate 742, 1 166 Abuse, substance 62 Adipocytes 44 1 Amniotic fluid 229, 618, 779, Arrhythmia 179, 195, 222, 223, Acanthosis 12 17 Adipose tissue 23 1, 69 1 1304, 1535 377,857,9 13, 1796 Accidents 5 1 1, 5 18 Adiposity 673 Amniotic leak, prolonged 1739 Arteriohepatic dysplasia 1642 Accretion 300 Admissions 825 Amoxicillin 8 19 Artery 1753 Acetaldehyde 777 Adolescence 1, 3, 4, 9, 10, 12, 16, Amphotericin 900, 1350, 1369 Artery, carotid 20 1 Acetaminophen 282, 297, 38 1, 19, 22, 24, 25 Ampicillin 11 14, 1147 Artery, mesenteric 372 390 Adrenal 14, 315,405,413,446 Amrinone 175,345 Artery, pulmonary 186, 2 17, 328, Acetylcholine 277 Adrenal hormones 18 Androgen 14,449, 465, 12 17 5 10 Acetyl-CoA 1200 Adrenal medulla 270 Anemia 20, 140, 143, 500, 545, Arthritis 1 167 N-Acetyl-P-D-glucosaminidase Adrenarche 4 13, 502 816, 835, 846, 888, 896, 904,
    [Show full text]
  • PRIMAXIN (Imipenem and Cilastatin)
    • Known hypersensitivity to any component of PRIMAXIN (4) HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ----------------------- WARNINGS AND PRECAUTIONS ----------------------­ PRIMAXIN safely and effectively. See full prescribing information • Hypersensitivity Reactions: Serious and occasionally fatal for PRIMAXIN. hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. If an allergic reaction PRIMAXIN® (imipenem and cilastatin) for Injection, for to PRIMAXIN occurs, discontinue the drug immediately (5.1). intravenous use • Seizure Potential: Seizures and other CNS adverse reactions, such Initial U.S. Approval: 1985 as confusional states and myoclonic activity, have been reported during treatment with PRIMAXIN. If focal tremors, myoclonus, or --------------------------- RECENT MAJOR CHANGES --------------------------­ seizures occur, patients should be evaluated neurologically, placed Indications and Usage (1.9) 12/2016 on anticonvulsant therapy if not already instituted, and the dosage of Dosage and Administration (2) 12/2016 PRIMAXIN re-examined to determine whether it should be decreased or the antibacterial drug discontinued (5.2). ----------------------------INDICATIONS AND USAGE ---------------------------­ • Increased Seizure Potential Due to Interaction with Valproic Acid: PRIMAXIN for intravenous use is a combination of imipenem, a penem Co-administration of PRIMAXIN, to patients receiving valproic acid antibacterial, and cilastatin, a renal dehydropeptidase inhibitor, or divalproex sodium results in a reduction in valproic acid indicated for the treatment of the following serious infections caused by concentrations. The valproic acid concentrations may drop below designated susceptible bacteria: the therapeutic range as a result of this interaction, therefore • Lower respiratory tract infections. (1.1) increasing the risk of breakthrough seizures. The concomitant use of • Urinary tract infections.
    [Show full text]
  • Peptide Handbook a Guide to Peptide Design and Applications in Biomedical Research
    Peptide Handbook A Guide to Peptide Design and Applications in Biomedical Research First Edition www.GenScript.com GenScript USA Inc. 860 Centennial Ave. Piscataway, NJ 08854 USA Phone: 1-732-885-9188 Toll-Free: 1-877-436-7274 Fax: 1-732-885-5878 Table of Contents The Universe of Peptides Reliable Synthesis of High-Quality Peptides Molecular structure 3 by GenScript Characteristics 5 Categories and biological functions 8 Analytical methods 10 Application of Peptides Research in structural biology 12 Research in disease pathogenesis 12 Generating antibodies 13 FlexPeptideTM Peptide Synthesis Platform which takes advantage of the latest Vaccine development 14 peptide synthesis technologies generates a large capacity for the quick Drug discovery and development 15 synthesis of high-quality peptides in a variety of lengths, quantities, purities Immunotherapy 17 and modifications. Cell penetration-based applications 18 Anti-microorganisms applications 19 Total Quality Management System based on multiple rounds of MS and HPLC Tissue engineering and regenerative medicine 20 analyses during and after peptide synthesis ensures the synthesis of Cosmetics 21 high-quality peptides free of contaminants, and provides reports on peptide Food industry 21 solubility, quality and content. Synthesis of Peptides Diverse Delivery Options help customers plan their peptide-based research Chemical synthesis 23 according to their time schedule and with peace of mind. Microwave-assisted technology 24 ArgonShield™ Packing eliminates the experimental variation caused by Ligation technology 26 oxidization and deliquescence of custom peptides through an innovative Recombinant technology 28 Modifications packing and delivery technology. 28 Purification 30 Expert Support offered by Ph.D.-level scientists guides customers from Product identity and quality control 31 peptide design and synthesis to reconstitution and application.
    [Show full text]
  • Jp Xvii the Japanese Pharmacopoeia
    JP XVII THE JAPANESE PHARMACOPOEIA SEVENTEENTH EDITION Official from April 1, 2016 English Version THE MINISTRY OF HEALTH, LABOUR AND WELFARE Notice: This English Version of the Japanese Pharmacopoeia is published for the convenience of users unfamiliar with the Japanese language. When and if any discrepancy arises between the Japanese original and its English translation, the former is authentic. The Ministry of Health, Labour and Welfare Ministerial Notification No. 64 Pursuant to Paragraph 1, Article 41 of the Law on Securing Quality, Efficacy and Safety of Products including Pharmaceuticals and Medical Devices (Law No. 145, 1960), the Japanese Pharmacopoeia (Ministerial Notification No. 65, 2011), which has been established as follows*, shall be applied on April 1, 2016. However, in the case of drugs which are listed in the Pharmacopoeia (hereinafter referred to as ``previ- ous Pharmacopoeia'') [limited to those listed in the Japanese Pharmacopoeia whose standards are changed in accordance with this notification (hereinafter referred to as ``new Pharmacopoeia'')] and have been approved as of April 1, 2016 as prescribed under Paragraph 1, Article 14 of the same law [including drugs the Minister of Health, Labour and Welfare specifies (the Ministry of Health and Welfare Ministerial Notification No. 104, 1994) as of March 31, 2016 as those exempted from marketing approval pursuant to Paragraph 1, Article 14 of the Same Law (hereinafter referred to as ``drugs exempted from approval'')], the Name and Standards established in the previous Pharmacopoeia (limited to part of the Name and Standards for the drugs concerned) may be accepted to conform to the Name and Standards established in the new Pharmacopoeia before and on September 30, 2017.
    [Show full text]
  • Drug-Related Laboratory Test Interference
    REFERENCES • Chun KY. Biotin Interference in Diagnostic Tests. Clinical Chemistry 2017; 63: 619-20. • da Silva-Colombeli AS, Falkenberg M. Analytical interfer- ASCLS Mission: ences of drugs in the chemical examination of urinary protein. Clinical Biochemistry 2007; 40: 1074-6. • Hart MH, de Vrieze H, Wouters D et al. Differential effect The mission of ASCLS is of drug interference in immunogenicity assays. Journal of Immunological Methods 2011; 372: 196-203. to make a positive impact • Lippi G, Daves M, Mattiuzzi C. Interference of medical contrast media on laboratory testing. Biochemia Medica Laboratory in health care through 2014; 24: 80-8. leadership that will • Nagase S, Kohguchi K, Tohyama K et al. Interference by Patient Safety Pralidoxime (PAM) salts in clinical laboratory tests. Clinica assure excellence in the Chimica Acta 2013; 416: 72-9. • Tsakiris DA. Direct Oral Anticoagulants-Interference With Tips: practice of laboratory Laboratory Tests and Mechanism of Action. Semin Hema- tol 2014; 51: 98-101. medicine. • Vasudevan S, Hirsch IB. Interference of Intravenous Vita- min C With Blood Glucose Testing. Diabetes Care 2014; 37: Drug-related E93-E4. • Williams GR, Cervinski MA, Nerenz RD. Assessment of Laboratory Test biotin interference with qualitative point-of-care hCG test devices. Clinical Biochemistry 2018; 53: 168-70. Interference • Amanatullah DF, Lopez MJ, Gosselin RC, Gupta MC. Case Report: Artificial Elevation of Prothrombin Time by Tela- For vancin. Clin Orthop Rel Res 2013; 471: 332-5. • Martin EL, Taylor HL. False-Positive Viral Serologies Due to Providers Intravenous Immunoglobulin Administration in a Case of Suspected Transfusion-Transmitted Disease. American Journal of Clinical Pathology 2012; 138: A256-A.
    [Show full text]
  • Non-Penicillin Beta-Lactam Drugs: a CGMP Framework for Preventing Cross- Contamination
    Guidance for Industry Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross- Contamination U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) April 2013 Current Good Manufacturing Practices (CGMPs) Guidance for Industry Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross- Contamination Additional copies are available from: Office of Communications Division of Drug Information, WO51, Room 2201 Center for Drug Evaluation and Research Food and Drug Administration 10903 New Hampshire Ave. Silver Spring, MD 20993-0002 Phone: 301-796-3400; Fax: 301-847-8714 [email protected] http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) April 2013 Current Good Manufacturing Practices (CGMP) Contains Nonbinding Recommendations TABLE OF CONTENTS I. INTRODUCTION....................................................................................................................1 II. BACKGROUND ......................................................................................................................2 III. RECOMMENDATIONS.........................................................................................................7 i Contains Nonbinding Recommendations Guidance for Industry1 Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross-Contamination This guidance
    [Show full text]
  • CEM Peptide Synthesis Brochure
    Unparalleled Peptide Synthesis cempeptides.com Contents CEM Overview 2 Innovations in Microwave Peptide Synthesis 2 Founding Fathers 3 Corporate Legacy Chemistry Technologies 4 HE-SPPS 6 CarboMAXTM 8 One Pot Coupling/Deprotection Peptide Synthesizers 10 Sequential vs Parallel 11 Synthesizer Comparison 12 Discover BioTM 12 Liberty LiteTM 13 Liberty BlueTM 13 Liberty Blue HT12TM 14 Liberty PRIMETM 16 Accessories & Upgrades Peptide Cleavage 17 Razor® SPPS Reagents 18 Fmoc Amino Acids 19 Oxyma Pure 19 Resins (ProTide™, Polystyrene) Large Scale Microwave Peptide Synthesis 22 Liberty PRO™ Customers 24 Testimonials 25 Support CEM Overview Innovations in Microwave Peptide Synthesis 1978 CEM Corporation founded as a new company, based on microwave laboratory instrumentation 2001 CEM launches a single mode microwave system for chemical synthesis 2003 CEM develops the world’s first automated microwave peptide synthesizer1 2007 CEM publishes research for optimized methods for aspartimide formation and epimerization under microwave SPPS2 2013 Liberty Blue™ peptide synthesizer developed based on High Efficiency Solid Phase Peptide Synthesis (HE-SPPS) 2014 HE-SPPS methodology published3 2016 CEM launches new universal load resins eliminating the need for pre-loaded resins historically used 2016 CEM offers the world’s first large-scale microwave peptide synthesis, with capabilities of up to 500 grams of a purified peptide, in a single batch 2016 CEM develops improved carbodiimide coupling methods for peptide synthesis at elevated temperature (CarboMAX™) 2017 CEM develops a novel one-pot coupling/ deprotection process reducing SPPS cycle time and waste usage (Liberty PRIME™) Founding Fathers (circa 1980) Chemist: Dr. Michael J. Collins (Middle) Electrical Engineer: Ron Goetchius (Left) Mechanical Engineer: Bill Cruse Jr.
    [Show full text]
  • Pharmaceuticals As Environmental Contaminants
    PharmaceuticalsPharmaceuticals asas EnvironmentalEnvironmental Contaminants:Contaminants: anan OverviewOverview ofof thethe ScienceScience Christian G. Daughton, Ph.D. Chief, Environmental Chemistry Branch Environmental Sciences Division National Exposure Research Laboratory Office of Research and Development Environmental Protection Agency Las Vegas, Nevada 89119 [email protected] Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada Why and how do drugs contaminate the environment? What might it all mean? How do we prevent it? Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada This talk presents only a cursory overview of some of the many science issues surrounding the topic of pharmaceuticals as environmental contaminants Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada A Clarification We sometimes loosely (but incorrectly) refer to drugs, medicines, medications, or pharmaceuticals as being the substances that contaminant the environment. The actual environmental contaminants, however, are the active pharmaceutical ingredients – APIs. These terms are all often used interchangeably Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada Office of Research and Development Available: http://www.epa.gov/nerlesd1/chemistry/pharma/image/drawing.pdfNational
    [Show full text]