Anti-VAC14 (Aa 711-760) Polyclonal Antibody (CABT-BL5957) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-VAC14 (aa 711-760) polyclonal antibody (CABT-BL5957) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit polyclonal antibody to Human VAC14.

Antigen Description The content of phosphatidylinositol 3, 5-bisphosphate (PtdInsP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdInsP2. Other components of this complex are the PtdInsP2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdInsP2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007

Immunogen Synthetic peptide, corresponding to a region within C terminal amino acids 711-760 (QLLSHRLQCV PNPELLQTED SLKAAPKSQK ADSPSIDYAE LLQHFEKVQN) of Human VAC14.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Sequence Similarities Belongs to the VAC14 family.Contains 6 HEAT repeats.

Cellular Localization Endosome membrane. Microsome membrane. Mainly associated with membranes of the late endocytic pathway.

Format Liquid

Size 50 μg

Buffer 97% PBS, 2% Sucrose

Preservative None

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]

GENE INFORMATION

Entrez Gene ID 55697

Protein Refseq NP_060522

UniProt ID Q08AM6

Chromosome Location 16q22.1

Pathway HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;

Function binding; receptor activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]