Systems Biology of Immunity to MF59-Adjuvanted Versus
Systems biology of immunity to MF59-adjuvanted SEE COMMENTARY versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood Helder I. Nakayaa,b,1, Elizabeth Clutterbuckc,1, Dmitri Kazmind,1, Lili Wange,1, Mario Cortesed, Steven E. Bosingerd,f, Nirav B. Patelf, Daniel E. Zakg, Alan Aderemg, Tao Donge, Giuseppe Del Giudiceh, Rino Rappuolih,2, Vincenzo Cerundoloe, Andrew J. Pollardc, Bali Pulendranb,d,2, and Claire-Anne Siegristi,2 aDepartment of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, 05508, São Paulo, Brazil; bDepartment of Pathology, Emory University School of Medicine, Atlanta, GA 30322; cOxford Vaccine Group, Department of Pediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre, Oxford OX3 9DU, United Kingdom; dEmory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329; eMedical Research Council Human Immunology Unit, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom; fDivision of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30322; gCenter for Infectious Disease Research, Seattle, WA 98109; hResearch Center, Novartis Vaccines, 53100 Siena, Italy; and iWHO Collaborative Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, 1211 Geneva, Switzerland Contributed by Rino Rappuoli, November 24, 2015 (sent for review April 29, 2015; reviewed by Adolfo Garcia-Sastre, Stefan H. E. Kaufmann, and Federica Sallusto) The dynamics and molecular mechanisms underlying vaccine immu- administered to over 5,000 children in clinical trials (11) and nity in early childhood remain poorly understood. Here we applied showed enhanced immunogenicity and efficacy compared with TIV systems approaches to investigate the innate and adaptive re- (2).
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