Anti-UNC5C (Aa 88-117) Polyclonal Antibody (DPABH-05511) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-UNC5C (aa 88-117) polyclonal antibody (DPABH-05511) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Immunogen Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 88-117 of Human UNC5C (NP_003719.2).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 400 μl

Buffer Constituent: 99% PBS

Preservative 0.09% Sodium Azide

Storage Store at 4°C. Aliquot and store at -20°C long-term.

GENE INFORMATION

Gene Name UNC5C unc-5 homolog C (C. elegans) [ Homo sapiens ]

Official Symbol UNC5C

Synonyms UNC5C; unc-5 homolog C (C. elegans); unc5 (C.elegans homolog) c; netrin receptor UNC5C;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Entrez Gene ID 8633

Protein Refseq NP_003719

UniProt ID A8K385

Chromosome Location 4q21-q23

Pathway Axon guidance; Developmental Biology; Netrin mediated repulsion signals; Netrin-1 signaling;

Function netrin receptor activity; receptor activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]