Anti-UNC5C (aa 88-117) polyclonal antibody (DPABH-05511) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Immunogen Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 88-117 of Human UNC5C (NP_003719.2). Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB Format Liquid Size 400 μl Buffer Constituent: 99% PBS Preservative 0.09% Sodium Azide Storage Store at 4°C. Aliquot and store at -20°C long-term. GENE INFORMATION Gene Name UNC5C unc-5 homolog C (C. elegans) [ Homo sapiens ] Official Symbol UNC5C Synonyms UNC5C; unc-5 homolog C (C. elegans); unc5 (C.elegans homolog) c; netrin receptor UNC5C; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved unc-5 homolog 3; protein unc-5 homolog 3; protein unc-5 homolog C; UNC5H3; Entrez Gene ID 8633 Protein Refseq NP_003719 UniProt ID A8K385 Chromosome Location 4q21-q23 Pathway Axon guidance; Developmental Biology; Netrin mediated repulsion signals; Netrin-1 signaling; Function netrin receptor activity; receptor activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.