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Visual Outcome of Pars Plana Vitrectomy Following Endophthalmitis – a Vitreo-Retinal Surgeon's Experience

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Visual Outcome of Pars Plana Vitrectomy Following Endophthalmitis – a Vitreo-Retinal Surgeon's Experience Medical Journal of Zambia, Vol. 47 (1): 33 - 38 (2020) Original Article Visual outcome of Pars Plana Vitrectomy following Endophthalmitis – A Vitreo-retinal Surgeon's Experience Sanjoy K. Das1 ,Osayem J. Otabor-Olubor2, Situma P Wanyama1 1Ispahani Islamia Eye Institute and Hospital (IIEIH), Dhaka, Bangladesh 2Ispahani Islamia Eye Institute and Hospital (IIEIH), Dhaka, Bangladesh1 and University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. ABSTRACT (p-value = 0.007). There was an association (although not strong) between age range and post- Purpose: To determine the visual outcome of pars operative visual improvement (p-value = 0.639). plana vitrectomy following endophthalmitis. Conclusion: Pars plana vitrectomy helps to prevent Methods: A retrospective hospital-based study of 20 or minimize ophthalmic complications from eyes of consecutive patients who had pars plana endophthalmitis, thus making it a necessary line of vitrectomy by a particular surgeon following treatment endophthalmitis. Pars plana vitrectomy is endophthalmitis in the Ispahani Islamia Eye therefore a safe and desirable definitive treatment Institute and Hospital, Dhaka, Bangladesh from for endophthalmitis, and it confers a good chance of August – December 2017. Using the Snellen's visual visual improvement. acuity chart, post-operative distant visual acuity improvement was graded 0– 9, with 0 meaning no INTRODUCTION improvement in visual acuity, and 9 meaning nine Pars plana vitrectomy (the intricate surgical removal lines of improvement in visual acuity from of vitreous gel from the vitreous cavity) has seen presenting best corrected visual acuity. remarkable progress in surgical technique and post- Results: Pre-operative corrected distant visual operative outcome in ophthalmic practices all over acuity (CDVA) ranged from perception of light to the world. It has become the main stay of treatment 6/36. Seventy percent of the patients had post- for many surgical vitreous and retinal conditions, operative visual improvement of varying degrees. e.g. retinal detachments, retinal haemorrhage, The mean pre-operative and post-operative CDVA retinal vaso-proliferative conditions, macular hole, were 2.20 logMAR and 1.40 logMAR respectively. intraocular foreign body, etc. In recent times, All the patients tractional retinal detachment and endophthalmitis is being managed by vitrectomy, corneal laceration with rhegmatogeneous retinal with documented positive outcome.1-3 detachment as co-morbidities did not have visual With judicious use of broad-spectrum and new improvement, and this was statistically significant g e n e r a t i o n a n t i b i o t i c s , p o s t - o p e r a t i v e endophthalmitis has reduced in incidence. However, Corresponding author: it still remains a major concern for every ophthalmic Dr Osayem J. Otabor-Olubor. Department of Ophthalmology, surgeon, as it confers an appalling visual prognosis. University of Benin Teaching Hospital, Previously, the only invasive component of the Benin City, Edo State. PMB 1111 [email protected] Key words: endophthalmitis, “pars plana vitrectomy”, “visual +2348034904123, +8801640569541 outcome”. 33 Medical Journal of Zambia, Vol. 47 (1): 33 - 38 (2020) established line of treatment for infective All the patients underwent a 3-port pars plana core endophthalmitis was injection of precise doses of vitrectomy with an Alcon Constellation Visual anti-microbials (with or without steroids) into the System, vitreous biopsy for microscopy, culture and mid-vitreous. Nonetheless, even with successful sensitivity and then had intravitreal antibiotics suppression of the infection, visual outcome was (vancomycin and ceftazidine). Perfluorocarbon often poor, largely due to conditions like cystoid liquid was used to flatten the retina of the patient macular oedema, tractional retinal detachment and with tractional retinal detachment and the one with retinal necrosis resulting from the post- rhegmatogeneous retinal detachment during inflammatory debris left within the vitreous cavity.4 surgery. This was followed by perfluorocarbon liquid-silicon oil exchange. Visual acuity was done The timing of the pars plana vitrectomy following for these patients with silicon oil in their vitreous endophthalmitis remains debatable, and lies with the cavities. All surgeries were done by a particular judgement and experience of the managing surgeon. Post-operative topical medications were ophthalmic surgeon, and the time of presentation of prednisolone eye drops, atropine eye drops and the patient. Immediate vitrectomy could be moxifloxacin eye drops. Systemic medications were desirable, as it would ensure early clearance of the prednisolone tablets, ciprofloxacin tablets and toxic infected vitreous for therapeutic and analgesics. investigative motives. Conversely, delayed vitrectomy could present the advantage of operating Data reviewed and analyzed included age, sex, a less inflamed eye with less friable intraocular cause of endophthalmitis, duration of tissues.3,5 endophthalmitis before pars plana vitrectomy and visual outcome after vitrectomy. Data obtained from METHODS the patients' case files were analyzed using using This was a retrospective hospital-based study of SPSS17.0 software (SPSS Inc., Chicago, IL, USA). consecutive 20 patients (20 eyes) with Categorical variables were analyzed using Fisher's endophthalmitis from various etiologies who exact test, with P < 0.05 taken as a level of statistical presented to the Retina department of the Ispahani significance. Pre-operative and post-operative Islamia Eye Institute and Hospital in Dhaka, corrected distant visual acuities (CDVA) for all the Bangladesh from August 2017 to December 2017. patients were measured and documented using the The study protocol was approved by the Research Snellen's visual acuity chart (perception of light, and Ethics Committee of the Ispahani Islamia Eye hand movement and counting fingers included). Institute and Hospital. The diagnosis of Four weeks post-operative CDVA was used for endophthalmitis was made by clinical examination analysis in all cases. The CDVA were then converted which was confirmed by B-scan ultrasonography. to the logarithm of the minimum angle of resolution The diagnostic clinical features included painful (logMAR) units for assessment of the mean pre- eye, severe and rapid deterioration in vision with a operative and post-operative CDVA. Improvement recent history of ocular surgery or injury to the eye. of visual acuity was graded as 0-9, with 0 meaning Other diagnostic clinical features were no improvement, and 9 meaning nine lines of redness/chemosis, +/-hypopyon in the anterior improvement from presenting CDVA with respect to chamber and marked vitreous inflammation. B-scan the Snellen visual acuity chart (perception of light, ultrasonography done for all the eyes diagnosed with hand movement and counting fingers included). The endophthalmitis showed significant vitreous study was done in strict adherence to the Helsinki opacification with cavitations and chorioretinal declaration and ethical guidelines. thickening. 34 Medical Journal of Zambia, Vol. 47 (1): 33 - 38 (2020) RESULTS Table 1: Association between age range and post- A total of 20 eyes of 20 patients that had pars plana operative visual improvement POST OPERATIVE VISION Total vitrectomy due to endophthalmitis were reviewed. Age (Years) They were 15 males and 5 females, giving a male to IMPROVED NOT IMPROVED 1-10 2(40.0) 3(60.0) 5(100.0) female ratio of 3:1. The age of the patients ranged 11-20 2(100.0) 0(0.0 ) 2(100.0) from 2.5 years to 77 years with a mean age of 44.075 41-50 1(50.0) 1(50.0) 2(100.0) years (SD± 28.785). The age ranges with the highest 51-60 2(100.0) 0(0.0) 2(100.0) number of patients were 1-10 years (5 patients) and 61-70 4(80.0) 1(20.0) 5(100.0) 71-80 3(75.0) 1(25.0 ) 4(100. 0) 61-70 years (5 patients) – Table 1. These had 4 males Total 14(70.0) 6(30.0) 20(100.0) and 1 female in each category. Pre-operative CDVA Fishers' Exact Test = 4.072; P-value = 0.639 ranged from perception of light to 6/36, with hand movements being the most common pre-operative Table 2: Pre-operative corrected distant CDVA (8; 40%), followed by counting fingers (7; visual acuity, time interval between onset of 35%) – Table 2. In 40% of the patients, the time symptoms of endophthalmitis and interval between the cause of endophthalmitis and presentation and grades of post-operative the manifestation of symptoms was two weeks, visual acuity improvement while it was one week in 25% and 4 weeks in 20% of the patients (Table 2). A majority (70%) of the Variables Frequency (n =20) Percent patients in this study experienced different degrees PL 4 20.0 HM 8 40.0 of post-operative visual improvements, while 30% CF 7 35.0 did not experience any improvement in their vision 6/36 1 5.0 after surgery (Table 2). The mean pre-operative and Interval (weeks) post-operative CDVA were 2.20 logMAR and 1.40 1.0 5 25 2.0 8 40 logMAR respectively. These correspond 3.0 1 5 respectively to hand movement (HM) and 6/150 4.0 4 20 respectively with the Snellen's visual acuity chart. 8.0 1 5 Ophthalmic co-morbidities included corneal 16.0 1 5 Grade s of VA improvement laceration (4 patients), diabetic macular oedema (2 0 6 30 patients), tractional retinal detachment (1 patient), 1 6 30 corneal laceration with rhegmatogeneous retinal 2 2 10 detachment (1 patient), corneal ulcer (1 patient), 3 1 5 5 2 10 cystoid macular oedema (1 patient) – Table 3. All 6 2 10 patients within the age groups of 11-20 years and 51- 9 1 5 60 years had improvement in their post-operative visual acuity. Sixty percent of the patients in the age *VA – visual acuity; CF – counting fingers close to face; HM – hand movement close to face; PL – perception of group of 1-10 years did not experience improvement light.
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