Antimicrobial Agents and Chemotherapy

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VOLUME 10 * NUMBER 6 * DECEMBER 1976 EDITORIAL BOARD GLADYS L. HOBBY, Editor-in-Chief (1980) U.S. Veterans Administration and the Infectious Disease Research Institute, East Orange, N.J. WALTER D. CELMER, Editor (1980) EDWARD W. HOOK, Editor (1981) Pfizer Inc., Groton, Conn. University of Virginia, Charlottesville JOEL G. FLAKS, Editor (1981) LEON H. SCHMIDT, Editor (1979) University ofPennsylvania, Philadelphia Southern Research Institute, Birmingham, Ala.

Theodore Anderson (1976) Ronald D. Hinsdill (1976) K. E. Price (1976) Vincent T. Andriole (1978) Richard Hornick (1977) Jack Remington (1976) Robert Austrian (1977) Susan B. Horwitz (1978) R. W. Rickards (1977) Arthur L. Barry (1977) Milton Huppert (1977) Richard Roberts (1976) John E. Bennett (1976) George Gee Jackson (1977) Richard Root (1977) Gerald P. Bodey (1977) Keith Jensen (1977) John Routien (1976) D. Buyske (1977) Francis Johnson (1977) Milton R. J. Salton (1978) Charlotte C. Campbell (1976) Thomas Jones (1977) Merle Sande (1976) Yves Chabbert (1977) E. H. Kass (1976) Jay Sanford (1977) Roy Cleeland (1977) Donald Kaye (1976) Arthur K. Saz (1976) Royston C. Clowes (1976) Wm. Kirby (1976) F. C. Sciavolino (1976) Leighton E. Cluff (1977) Vernon Knight (1977) Oldrich K. Sebek (1977) Kenneth W. Cochran (1978) Jordan Konisky (1977) William M. Shannon (1977) Roger Cole (1976) Robert G. Loudon (1977) John C. Sherris (1976) Frank Collins (1976) Joan Lusk (1977) Robert W. Sidwell (1978) Julian Davies (1976) Gerald L. Mandell (1977) Sigmund S. Socransky (1977) Lawrence E. Day (1977) Gerald Medoff (1977) P. Frederick Sparling (1978) Theodore Eickhoff (1976) L. Bruce Mellett (1976) Gene Stollerman (1977) Arthur English (1977) S. Mitsuhashi (1977) R. Sutherland (1976) H. L. Ennis (1977) R. B. Morin (1976) Vera L. Sutter (1978) David S. Feingold (1978) Bernard Moss (1978) Morton N. Swartz (1976) Robert J. Fitzgerald (1977) John D. Nelson (1977) Clyde Thornsberry (1976) Anthony J. Glazko (1978) Harold C. Neu (1977) Ralph Tompsett (1976) Irving H. Goldberg (1976) J. F. Niblack (1977) Marvin Turck (1977) Harry Gooder (1976) L. Nickell (1977) Hamao Umezawa (1978) M. Gorman (1977) Thomas C. Orihel (1976) Donald Van Harken (1976) Arthur P. Grollman (1978) T. J. Perun (1977) D. Vazquez (1977) Jack Gwaltney (1977) Charles A. Plate (1976) John Washington II (1978) Fred Hahn (1976) Burton M. Pogell (1978) B. Weisblum (1976) Michael Higgins (1977) Robert A. Day, Managing Editor Gisella Pollock, Director ofEditorial Services Susan Birch, Production Editor 1913 I St., N.W., Washington, D.C. 20006 EX OFFICIO Harlyn 0. Halvorson, President (1976-1977) A. Frederick Rasmussen, Jr., Vice-President (1976-1977) J. Mehsen Joseph, Secretary Brinton M. Miller, Treasurer Antimicrobial Agents and Chemotherapy, an interdisci- position of submitted manuscripts, and general editorial plinary publication of the American Society for Micro- matters should be directed to the ASM Publications Office, biology, 1913 I St., N.W., Washington, D.C. 20006, is de- 1913 I St., N.W., Washington, D.C. 20006 (area 202 voted to the dissemination of knowledge relating to all 833-9680). aspects of antimicrobial agents and chemotherapy, including cancer chemotherapy. Antimicrobial Agents and Chemotherapy is published monthly, and the twelve num- bers are divided into two volumes per year. The nonmem- Second class postage paid at Washington, D.C. 20006, and at ber subscription price is $0 per year. The member sub- additional mailing offices. scription price is $13 per year. Single copies are $5. Cor- Made in the United States of America. respondence relating to subscriptions, reprints, defective Copyright 0 1976, American Society for Microbiology. copies, availability of back issues, lost or late proofs, dis- All Rights Reserved. Author Index Adams, Monica A., 872 Hall, Wendell H., 902 Peter, Georges, 893 Anderson, J. D., 872 Hammerberg, Susan, 869 Pogwizd, Steven M., 878 Hendley, J. Owen, 899 Barrington, Jane C., 872 Hryniewicz, Waleria, 912 Rawal, B. D., 915 Schierl, Elizabeth A., 902 Chalgren, Sarah, 926 Kaufman, Robert E., 885 Shepherd, C. A., 872 Charles, B. G., 915 Kluge, Ronica M., 889 Spence, W. N., 872 Stevens, Lynne I., 918 D'Alessandri, Robert M., 889 Dodd, Wendell K., 899 Lerner, Stephen A., 878 Tagg, John R., 912 Dougherty, Paula F., 923 McNeely, David J., 889 Varnell, Emily D., 885 Edmiston, Charles E., Jr., 918 Manion, Robert E., 902 Ekwo, Edem, 893 Marks, Melvin I., 869 Wegner, Dennis L., 921 Matthews, Thomas R., 923 Weinmaster, Gerry, 869 Gerding, Dale N., 902 Mohan, Kanwal, 918 Wenzel, Richard P., 899 Gordon, Ralph C., 918 Wilkins, Tracy D., 926 Gwaltney, Jack M., Jr., 899 Neblett, Thomas R., 921 Yotter, David W., 923 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY INSTRUCTIONS TO AUTHORS Submit manuscripts in duplicate (original and one number. The Literature Cited section should be typed copy) to ASM Publications, 1913 1 St., N.W., in alphabetical order, by first author, and numbered. Washington, D.C. 20006. Each reference should include the title of the article General policy. Any manuscript submitted must be and inclusive pagination. Names of journals are ab- a report of unpublished original research, which is not breviated according to Bibliographic Guide for Editors being considered for publication elsewhere. Each & Authors (Amencan Chemical Society, 1974). Cita- manuscript should present the results of an independ- tions of abstracts, theses, patents, "unpublished data," ent, cohesive study; numbered series papers are dis- "personal communication," and "in press" will not be couraged. When a submitted manuscript is judged to accepted in the Literature Cited. be more appropriate for the subject scope of one of Tables. Each table should be typed on a separate the other ASM journals, the Editors will transfer it page. The data should be arranged so that columns of to that journal for consideration, so notifying the like material read down, not across. The headings author. 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Each figure should be num- Rev. 40:116-167) for E. coli and Sanderson (Bac- bered and should include the name of the author, teriol. Rev. 36:558-586) for Salmonella. For plasmids either in the margin or on the back (marked lightly and plasmid-specified activities, genetic symbols should with, a soft pencili. Graphs (submit as photographs) follow Novick et al. (Bacteriol. Rev. 40:168-189, should be finished drawings not needing further art- 1976). The standard italicized, lower-case, three-letter work or typesetting. Absolutely no part of a graph symbol should be used for genotype designation, and should be typewritten (except the legend, which should care should be taken to avoid using this symbol for be typed on a separate page). All lettering should be the designation of phenotype. The latter can be abbre- done with a lettering set. 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The accepted form for Notes is somewhat stylistic conventions. different from the foregoing. Contributors should con- Form of manuscript. All parts of the manuscript sult a recent issue for style. Notes should not exceed should be typed double-space or, preferably, triple- 500 words. The Abstract should not exceed 25 words. space. Most manuscripts can and should be divided into Copyright. Once a paper has been published in this the following sections: Abstract, Introduction, Ma- journal, which is a copyrighted publication, the legal terials and Methods, Results, Discussion, Acknowl- ownership of all parts of the paper, including the illus- edgments, and Literature Cited. trations, has passed from the author to the ASM. If Title. A single statement of the subject of a paper is the same author, or any author, wishes to republish preferred to a main title-subtitle arrangement. A short material previously published in this journal, he must version of the title (no more than 46 characters and first receive written permission from ASM. spaces) should be supplied for use as a running head. Reprints. Reprints (in multiples of 100) may be pur- Abstract. An Abstract appears at the beginning of chased by contributors. A table showing the cost of- each paper. The Abstract should not exceed 200 words. reprints, and an order form, will be sent with the Literature Cited. In the text, references are cited by proof. ACKNOWLEDGMENT

The Editors wish to express their thanks to the following individuals who so kindly refereed the papers submitted for publication during the past year.

Fred Allison, Jr. Lucien B. Guze Sidney Pestka John P. Anhalt John H. Hanks William Prusoff Donald Armstrong William L. Hanson Michael F. Rein Harry N. Beaty William A. Held James A. Retsema Donald Beck J. Owen Hendley John C. Ribble E. Lovell Becker William L. Hewitt Kenneth Richardson Ronald Bentley Paul D. Hoeprich Mark H. Richmond J. S. Binford King K. Holmes Glenn D. Roberts E. Thomas Bithell L. H. Huang Jon E. Rosenblatt Warren K. Bolton John H. Huffman Leon D. Sabath Charles S. Bryan Dorris J. Hutchison W. Eugene Sanders, Jr. Lawrence E. Bryan George A. Jacoby Joseph L. Sardinas Ward E. Bullock Geoffrey M. Jeffery Jerome A. Schiff Charles C. J. Carpenter Joseph E. Johnson III David Schlessinger Donald B. Clewell Warren D. Johnson, Jr. Charles C. Shepard C. Glenn Cobbs Thomas Jones Gerald D. Shockman Robert B. Couch Akira Kaji Thomas F. Smith John P. Craig Jerome 0. Klein Katherine Sprunt Eric Cundliffe Bruce C. Kline Joseph P. Stankewich Naomi Datta Monica M. Kluge Rolf Sternglanz Victor del Bene George S. Kobayashi David Stone Floyd W. Denny Calvin M. Kunin Weichen Tien Peter Dineen Donn J. Kushner Alexander Tomasz R. Gordon Douglas A. Martin Lerner John P. Utz Richard J. Duma Matthew E. Levison Henry J. Vogel W. Edmund Farrar, Jr. William R. McCabe Henry Wagner H. G. Fauda Evan W. McChesney Morton M. Weber Robert Fekety Christopher K. Mathews Louis Weinstein Patricia Ferrieri John M. Matsen Peter G. Welling Sydney M. Finegold Elizabeth C. Miller Richard P. Wenzel Coy D. Fitch Leonard E. Mindich Les Werbel James A. Fuchs Barbara H. Minshew Arthur C. White Raymond Furner Charles E. Moppett Ruth H. Wichelhausen Hans Gadebusch A. B. Nesburne Paul Wiesner Alfred Goldberg Masayasu Nomura Lee J. Wilkoff J. Thomas Grayston Carl Norden Emanuel Wolinsky Richard Guerrant Michio Oishi Martha D. Yow AUTHOR INDEX VOLUME 10 Adams, Monica A., 872 Burch, K., 464 Esparza, Jose, 176 Ahern, Mary Jean, 457 Burt, Sharon J., 567 Evangelisti, D. G., 89 Aitken, Connie L., 436 Busch, David F., 713 Ajello, Libero, 75 Fanning, W. Lee, 80 Alam, A. K. M. Jamiul, 610 Cabana, B. E., 307 Farrar, W. Edmund, Jr., 123 Anderson, J. D., 872 Capmau, M. L., 258 Fass, Robert J., 34 Andersson, Karl-Erik, 604 Chabbert, Y. A., 795 Feigin, Ralph D., 322 Andriole, Vincent T., 457 Chadha, K. C., 682 Feigl, Polly, 436 Appel, Gerald B., 623 Chalgren, Sarah, 926 Ferretti, Joseph J., 274 Arcieri, George, 827 Chapin, S. E., 856 Field, Charles R., 727 Chappell, W. Adrian, 344 Finegold, Sydney M., 713, 736 Baca, B., 258 Chardon, H., 258 Finkelstein, Frederic O., 457 Badal, R. E., 83 Charles, B. G., 915 Finley, Ruth, 370 Baird, Ian M., 626 Chello, P., L., 185 Fisher, E., 464 Baker, Carol J., 128 Cheng, Yung-Chi, 119 Flournoy, D. J., 864 Balfour, Henry H., Jr., 866 Chisholm, D. R., 426 Fortner, Clarence L., 837 Bardos, T. J., 682 Chiu, Peter J. S., 277 Freimer, Earl H., 288 Barrett, Fred F., 128 Chow, A. W., 102 Frey, C. A., 543 Barrington, Jane C., 872 Clark, D. C., 215 Fu, Kwung P., 511, 526 Barry, A. L., 83 Cohen, S., 139 Fuchs, P. C., 146 Bartholomew, Luanna, 507 Collins, M. S., 318 Fukada, Shigemi, 1 Barza, Michael, 421, 569 Condon, R. G., 363 Baum, Jules, 569 Cooksey, Robert C., 123 Gaafar, Hassan A., 417 Becker, Jeffrey M., 483 Cox, F., 464 Galgiani, John N., 721 Becker, R. O., 856 Coyle, Marie B., 436 Gerding, Dale N., 850, 902 Beebe, J. L., 179 Cupp, James, 96 Gerster, J. F., 20 Bellinger, Mary Ann, 417 Girard, A. E., 89 Benedictson, J., 768 Girard, Dennis, 491 Berger, Stephen, 421 D'Alessandri, Robert M., 889 Glasgow, Lowell A., 668, 691 Berger, T. J., 856 Daschner, Franz D., 802 Goebel, P., 258 Bernardo, Peter D., 283 Del Bene, Victor E., 106 Goedde, Lola W., 253 Berquist, Kenneth R., 571 Demain, A. L., 265 Goldberger, Mark J., 623 Betts, Robert F., 253 Denes, Alexander E., 436 Gordon, Ralph C., 918 Bhathena, Dinyar, 555 DeRegis, R. G., 426 Grant, Robert B., 762 Bierman, Richard, 856 Desser, Kenneth B., 447 Greenstone, G., 399 Bieth, G., 795 Dilworth, John A., 450 Greenwood, D., 249 Black, H. R., 814 Dixon, John H., Jr., 164 Greenwood, David, 824 Blackman, Jane, 234 Dodd, Wendell K., 899 Griffith, R. S., 814 Blackwell, C. Caroline, 288 Domin, Barbara A., 119 Grinsted, J., 753 Blazevic, Donna J., 866 Dominik, J. W., 549 Guerrant, Richard L., 450 Bobek, Miroslav, 119 Dougherty, Paula F., 923 Guevarra, Lucille O., 809 Bodey, Gerald P., 652 Douglas, R. Gordon, 253 Gump, Dieter, 80 Bolton, W. Kline, 450 Dowling, John N., 809 Guze, L. B., 102, 462 Bond, John H., 639 Drach, John C., 64 Gwaltney, Jack M., Jr., 899 Bouanchaud, D. H., 258, 795 Due, Susan L., 630 Bourque, Michael, 157 Duma, Richard J., 370 Hahn, Davis M., 837 Bradshaw, M. W., 467 Duval, J., 258 Hall, Henrietta E., 344 Breinig, Mary K., 28 Hall, Wendell H., 850, 902 Briedis, Dalius J., 592 Earhart, C. F., 150 Hamilton, John R., 691 Brier, G. L., 814 Ebert, James W., 571 Hammerberg, S., 399 Brotherton, Thomas, 322 Edmiston, Charles E., Jr., 918 Hammerberg, Susan, 869 Broughton, Alan, 652 Effinger, L. J., 83 Hardi, Robert, 682 Brown, Arthur, 277 Ehret, Josephine M., 241 Hasilik, Andrej, 402 Brown, K. N., 768 Eickenberg, H. U., 733 Hasuda, K., 573 Bruckner, H. W., 185 Eickhoff, Theodore C., 241 Heifetz, C. L., 543 Bryan, L. E., 573 Ekwo, Edem, 893 Helstad, Arlan G., 727 Buck, R. E., 426 English, Arthur R., 89, 132, 491 Heman-Ackah, Samuel M., 223 Bullock, Ward E., 555 Ernst, E. Chaim, 421 Hendley, J. Owen, 899 ii AUTHOR INDEX ANTimicRoB. AGENTS CHZMOTHER. Hirschman, Shalom Z., 25, 384 Le Goffic, F., 258 Naider, Fred, 483 Ho, Y. K., 682 Leitner, F., 426 Nakamoto, Shoji, 1 Hoeffler, U., 387 Lerner, Stephen A., 878 Nakamura, Shinichi, 779 Holloway, B. W., 411, 573 Levin, N., 464 Nathan, C., 139 Horn, Robert G., 164 Levinson, Warren, 234 Neblett, Thomas R., 921 Horodniceanu, Thea, 795 Levison, Matthew E., 188 Neu, Harold C., 511, 526, 535, Hottendorf, G. H., 307 Lichliter, Wayne D., 483 623 Howard, Jorge B., 205 Lietman, Paul S., 347 Nishida, Minoru, 1 Hryniewicz, Waleria, 912 Ligeti, P., 179 Novo, Ernesto, 176 Hughes, R. G., Jr., 682 Lilly, Ralph B., 447 Nuttall, Charles E., 555 Lindmark, Donald G., 476 Iglewski, Barbara H., 354 Line, Verle D., 861 O'Callaghan, Cynthia H., 245 Inoue, Satoru, 779 Long, James F., 277 Ogawa, Mayumi, 191 Inuzuka, Manabu, 325, 333 Lopez, Ruben, 697 O'Grady, F., 249 Ishida, Nakao, 14 Luft, Friedrich C., 845 Oka, Tetsuo, 579 Islam, M. Rafiqul, 610 Luke, Robert G., 555 Okada, Naohiko, 1 Iyobe, S., 573, 799 Lynch, John E., 89, 132 Olsen, Gregg A., 668 Overall, James C., Jr., 668, 691 Jackson, Jean, 234 McCardell, Barbara A., 498 Jacob, Ginette B., 623 McCord, Ronald S., 28 Padhye, Arvind A., 75 Jick, Hershel, 80 McCracken, George H., Jr., 205 Pappagianis, D., 318 Johnson, Deanne, 354 Mc~Kellar, Robin C., 765 Parry, Michael F., 623 Johnson, James E., 211 McKenzie, Colin N., 765 Pasiecznik, Karen A., 677 Jones, R. N., 146 McNeely, David J., 889 Paxton, Larry, 773 Jones, Sue M., 866 McRipley, R. J., 38, 45 Pearson, I. A., 543 Madhavan, T., 464 Perkins, Robert L., 34 Kabins, S. A., 139 Mahoney, David F., 470 Peter, Georges, 893 Kaminura, Toshiaki, 1 Majid, M. A., 610 Petrocheilou, V., 753 Kane, Anne, 569 Mallette, M. F., 613 Phair, John P., 626 Kau, Donald L. K., 630 Manion, Robert E., 902 Pickering, Larry K., 652 Kauffman, Carol A., 626 Mardh, Per-Anders, 604 Pickett, M. J., 102 Kaufman, Herbert E., 885 Marks, Melvin I., 399, 869 Pifia, Carmen I., 176 Kaye, Donald, 188 Marmion, LeRoy C., 447 Pogwizd, Steven M., 878 Kayser, F. H., 664 Marr, J. J., 707 Pohlod, D., 464 Keim, G. R., Jr., 687 Martel, A., 258 Polish, Louis, 96 Keith, Alec, 96 Matthews, Thomas R., 923 Pootjes, C. F., 498 Kelleher, J. J., 229 Mattie, H., 441 Postic, Bosko, 809 Kern, Earl R., 668, 691 Mayhall, C. G., 707 Poutsiaka, J. W., 687 Kisch, Alexander L., 507 Maynard, James E., 571 Powell, James T., 639 Klastersky, J., 395 Medoff, G., 707 Prasad, S. S. S. V., 293 Kleit, Stuart A., 845 Melethil, Srikumaran, 421 Price, K. E., 426 Kluge, Ronica M., 889 Meyer, Richard D., 677 Primm, R. Kirby, 164 Ko, H. L., 387 Meyers, Burt R., 25, 384 Prior, Richard B., 34 Komarmy, Louis, 564 Mikelens, Peter, 234 Pulverer, G., 387 Koppel, G. A., 470 Miki, Kazuyo, 1 Purdy, Michael A., 182 Kraus, Linda L., 677 Miller, George, 277 Pursiano, T. A., 426 Kromhout, James P., 850 Miller, George H., 827 Kulesza, J. S., 687 Miller, M. M., 687 Quay, John F., 630 Kumagai, Katsuo, 57 Miller, Warren M., 630 Quinn, E. L., 464 Kunin, Calvin M., 503 Mills, B. J., 411 Quintiliani, Richard, 157 Kureshi, Lubna Afzal, 713 Misiek, M., 426 Kurzynski, Terrence A., 727 Mitsuhashi, S., 573, 779 Rahaman, M. Mujibur, 610 Kushner, Donn J., 765 Miyano, Hiroshi, 325, 333 Rattie, Elisabeth S., 283 Kvam, D. C., 20 Moe, J. B., 549 Ravin, Louis J., 283 Mohan Kanwal, 918 Rawal, B. D., 915 Lambe, D. W., Jr., 112 Mohs, Edgar, 205 Reese, Richard E., 253 Lampe, Mary F., 436 Molenkamp, G. C., 786 Retsema, James A., 132, 491 Landesman, Sheldon, 837 Montgomerie, J. Z., 102 Reusser, Fritz, 618 Larson, E. W., 770 Morahan, Page S., 28 Ribner, Bruce, 25 Laslie, W. W., 112 Morioka, Kayoko, 191 Richmond, M. H., 215, 219, 753 Lawton, William D., 417 Morse, Stephen A., 354 Ripa, Torvald, 604 Lee, B. K., 363 Muller, Mikl6s, 476 Robson, Hugh G., 592, 646 Lee, Wie-Shing, 564 Murakawa, Takeo, 1 Rohde, Wolfgang, 234 Lees, Tracy, 322 Murphy, Bert L., 571 Rohlfing, S. R., 20 * * VOL. 10, 1976 AUTHOR INDEX Ronda-Lain, Conchita, 697 Stevens, David A., 447, 721 Waldron, James A., 164 Rozgonyi, Ferenc, 377 Stevens, Lynne I., 918 Walker, J. S., 549, 770 Ruckinsky, Tom, 96 Stone, William J., 164 Wanda, Paul, 96 Ruiz, Daniel E., 34 Strausbaugh, Larry J., 450 Wannamaker, L. W., 299 Strong, James E., 652 Ward, Margie, 274 Sagai, H., 573 Sullivan, Hugh R., 630 Washington, John A., II, 211 Saito, Noriyuki, 14 Sullivan, John J., 850 Watanakunakorn, Chatrchai, Sakamoto, Hiroshi, 1 Sutter, Vera L., 713, 736 382 Sande, Merle A., 450 Suzuki, Fujio, 14 Waterman, N. G., 733 Sanders, Christine C., 519 Swanby, S., 768 Webb, Bette J., 128 Sandham, H. J., 196, 200 Sykes, R. B., 245 Wegner, Dennis L., 921 Sands, Jeffrey, 96 Weinmaster, Gerry, 869 Santanam, P., 664 Tagg, John R., 299, 912 Weinrich, A. Elise, 106 Santoro, Jerome, 188 Tanner, Widmar, 402 Weinstein, M. J., 363, 827 Sasaki, Kenji, 14 Tapia, Alfonso, 697 Weld, H. G., 196, 200 Sawai, Tetsuo, 191 Taylor, Diane E., 762 Wenzel, Richard P., 899 Scharfenberger, L., 733 Taylor, Richard L., 613 Westerman, E. L., 467 Schierl, Elizabeth, A., 902 Thijssen, H. H. W., 441 Whitby, J. L., 598 Schimpff, Stephen C., 87 Thorne, Grace M., 123 Whitcher, Jack, 234 Schling, Marion, 417 Thys, J. P., 395 White, Lendell A., 344 Schwartz, Pauline M., 64 Tilton, Richard C., 157 White, S., 776 Scott, Rita E., 646 Tipple, Margaret, 773 White, Thomas J., 347 Segal, Ester, 75 Tomasz, Alexander, 697 Whitney, R. R., 38, 45 Sesnie, J. C., 543 Tomoeda, Munemitsu 325, 333 Wiernik, Peter H., 837 Severin, M. J.,-380 Toyama, Hiromi, 333 Wiley, J. L., 380 Shadomy, Smith, 733, 776 Trujillo, Hugo, 205 Wilkins, Tracy D., 926 Sharma, Ram A., 119 Trust, T. J., 598 Williams, T. W., Jr., 467 Shaw, William V., 347 Tsai, Y. H., 426 Wilson, Stephen G., 519 Shepherd, C. A., 872 Tuke, Gregory C., 288 Wlodkowski, T. J., 179 Sherris, John C., 436 Turner, J. R., 470 Wolny, J. D., 814 Shethna, Y. I., 293 Tzianabos, T., 344 Woods, D. R., 567 Shimizu, Fumio, 57 Wotton, Sandra, 215, 219 Wright, Walter E., 861 Shimizu, Masanao, 779 Utz, C. J., 776 Shimizu, Yoshinobu, 57 Uwaydah, Marwan, 52 Shipman, Charles, Jr., 64 Yamagishi, Saburo, 191 Shive, Karen, 150 Yancovitz, Stanley, 25 Sibley, P. L., 687 Vandamme, E. J., 265 Vanderkelen, B., 395 Yaremchuk, K., 464 Siebert, W. T., 467 Yielding, K. Lemone, 182 Silver, Barry, 399 Van Harken, D. R., 307 Varani, J., 229 Yokota, Yoshiko, 1 Slepack, Jerry M., 626 Yoon, Y. H., 687 Smilack, J. D., 467 Varnell, Emily D., 885 Vaughan, Patrick, 354 Yoshikawa, Thomas T., 462 Snipes, Wallace, 96 Yoshimori, R. N., 102 Solomons, I. A., 89 Veerkamp, J. H., 786 Verbist, L., 173, 657 Yotter, David W., 923 Soussy, C. J., 258 Young, Viola Mae, 837 Spadaro, J. A., 856 Yrios, John W., 727 Spence, W. N., 872 Wadso, Ingemar, 604 Yum, Moo Nahm, 845 Standiford, Harold C., 837 Wagman, G. H., 363 Staniforth, Susan E., 245 Waitz, J. Allan, 827 Stephen, E. L., 549, 770 Waks, Susan B., 697 Zaidi, I. H., 687 SUBJECT INDEX VOLUME 10 Acanthamoeba species toxicological studies in mice, rats, and dogs, 687 susceptibility to a variety of therapeutic agents, Amphotericin B methyl ester 370 toxicological studies in mice, rats, and dogs, 687 Acinetobacter calcoaceticus var. anitratus Ampicillin susceptibility to minocycine, 102 epidemiology of bacterial resistance, 872 2'-Adenylyltransferase short-term storage in microdilution trays for anti- enzymatic adenylylation as a means of determin- microbial susceptibility tests, 83 ing aminoglycoside antibiotic concentrations in susceptibility ofH. influenzae type b, 322 serum, 664 triple crossover study on absorption and excre- 4'-Adenylyltransferase tion, 173 enzymatic adenylylation as a means of determin- 9-3-D-Arabinofur4nosyladenine 5'-monophosphate ing aminoglycoside antibiotic concentrations in effect on experimental herpes simplex keratitis, serum, 664 885 Aeromonas hydrophila 9-,&D-Arabinofuranosylhypoxanthine 5'-monophos- inducible oxacillin-hydrolyzing penicillinase iso- phate lated from fish, 191 effect on experimental herpes simplex keratitis, Agrobacterium tumefaciens 885 chemical nature of agrocin 84 and its effect on a Arabinosyladenine virulent strain, 498 antiviral activity in herpes simplex virus-infected Agrocin 84 KB cells, 64 chemical nature, 498 Arabinosylhypoxanthine effect on a virulent strain of A. tumefaciens, 498 antiviral activity in herpes simplex virus-infected 5-Allyl-2'-deoxyuridine KB cells, 64 antiviral action and cellular toxicity, 119 Ascitic fluid Amikacin antibiotic penetrance in dogs, 850 activity againstP. aeruginosa andEnterobacteria- ceae, 592 Bacillus brevis ATCC 9999 activity alone and in combination with carbenicil- nutrition, 265 lin against S. marcescens, 878 Bacillus megaterium comparative pharmacology with kanamycin in 45 mode of action of penicillins, 579 neonates, 205 Bacillus thuringiensis subsp. thuringiensis effect of renal failure and dialysis on serum con- mode ofaction ofan antitumor protein on Yoshida centration, 464 ascites sarcoma cells, 293 5"-Amino-5"-deoxybutirosin Bacteriocin antibacterial activity in vitro in mice, 543 production by group A streptococcal L-forms, 912 Aminoglycoside production by N. gonorrhoeae, 417 concentrations in peritoneal capsular fluid in rab- Bacteriophage q)6 bits, 902 inactivation by butylated hydroxytoluene and bu- effect of cindamycin on activity in a murine tylated hydroxyanisole, 96 model ofE. coli infection, 893 Bacteriophage lambda Aminoglycoside antibiotics inhibition of development by R plasmids of the H new plasmid-mediated nucleotidylation in S. au- incompatibility group, 762 reus, 258 Bacteriophage Ti Aminoglycosides inhibition of development by R plasmids of the H activity against gentamicin-resistant P. aerugi- incompatibility group, 762 nosa, 399 Bacteriophage T7 enzymatic adenylylation by 4'-adenylyltransfer- inhibition of development by R plasmids of the H ase and 2'-adenylyltransferase for determining incompatibility group, 762 concentrations, 664 Benzylpenicillin mutants of P. aeruginosa that show specific hy- short-term storage in microdilution trays for anti- persensitivity, 411 microbial susceptibility tests, 83 S. aureus strains displaying unusual resistance, Beta-lactam antibiotics 519 synergy of mecillinam in combination, 535 susceptibility of gentamicin-resistant Enterobac- Beta-lactamase teriaceae and P. aeruginosa, 677 activity in anaerobic bacteria, 106 Amoxycillin Beta-lactamases triple crossover study on absorption and excre- substrate inhibition, 470 tion, 173 susceptibility of seven cephalosporins, 219 Amphotericin B Bifidobacterium bifidum subsp. pennsylvanicus nephrotoxicity, 555 effects of antibiotics on metabolism of peptidogly- new medium for in vitro susceptibility studies, 776 can, protein, and lipids, 786 iv VOL. 10, 1976 SUBJECT INDEX v BL-3849A dual mode of action, 245 antiviral activity, 691 preparation of intestinal villi useful for studying BL-P1654 hydrolysis-rates of esters, 861 activity in vitro as compared with ticarcillin and Cephalosporins carbenicillin, 241 ability to penetrate the surface layers of E. coli, BL-S786 219 laboratory evaluation, 426 antibacterial activity against Enterobacteriaceae Butylated hydroxyanisole and nonfermentative gram-negative bacilli, 657 inactivation of bacteriophage 46, 96 comparative study of seven, 219 Butylated hydroxytoluene comparison ofin vitro activity against gram-nega- inactivation of bacteriophage )6, 96 tive and -positive bacteria resistant to cepha- loridine, 507 comparison of thrombophlebitis associated with Candida albicans three antibiotics, 467 basis for the design of anticandidal agents from penetration in E. coli of beta-lactamase-nonsus- studies of peptide utilization, 483 ceptible, 215 Carbenicillin substrate inhibition ofbeta-lactamases, a method activity against gentamicin-resistant P. aerugi- for predicting enzymatic stability, 470 nosa, 399 susceptibility of respiratory tract anaerobes, 713 activity in combination with gentamicin, amika- susceptibility to beta-lactamases, 219 cin, and netilmicin against S. marcescens, 878 Cephalothin activity in vitro as compared with ticarcillin and association in rises in blood urea nitrogen, 80 BL-P1654, 241 combined with ticarcillin as therapy in granulocy- short-term storage in microdilution trays for anti- topenic cancer patients, 837 microbial susceptibility tests, 83 comparison of thrombophlebitis associated with susceptibility testing with 100-;lg disks, 112 cephapirin and cefamandole, 467 synergistic activity in combination with gentami- lack of significant in vitro antagonism with peni- cin in experimentalPseudomonas bacteremia in cillin and rolitetracycline, 802 neutropenic rats, 646 pharmacokinetics, 421 Carboxypeptidase Y short-term storage in microdilution trays for anti- inhibition of synthesis rate by tunicamycin in S. microbial susceptibility tests, 83 cerevisiae, 402 susceptibility ofS. aureus strains, 707 ['4C]cefaclor Cephapirin metabolism in three species of laboratory ani- comparative pharmacokinetics and metabolism in mals, 630 laboratory animals and humans, 307 Cefamandole comparison of thrombophlebitis associated with comparison of thrombophlebitis associated with cephalothin and cefamandole, 467 cephalothin and cephapirin, 467 pharmacokinetics, 421 concentration in serum interstitial fluid, bile, and Cephradine urine, 733 pharmacokinetic interpretation of levels in se- in vitro and clinical pharmacokinetics, 814 rum, 283 pharmacokinetics, 421 Chloramphenicol pharmacokinetics in patients undergoing hemodi- enzymological microassay, 347 alysis and peritoneal dialysis, 457 susceptibility ofH. influenzae type b, 322 pharmacokinetics in the presence of renal failure Cholera and in patients undergoing hemodialysis, 623 effects ofdoxycycline in actively purging patients, Cefatrizine 610 evaluation in vitro as compared with other cepha- Cinoxacin losporins, 288 antimicrobial-activity against 2,968 clinical bacte- susceptibility ofH. influenzae type b, 322 rial isolates, 146 Cefazolin compared in vitro with nalidixic acid and oxolinic pharmacological study during intermittent and acid, 918 continous infusion, 395 Citrobacter freundii treatment of acute enteric fever, 52 antibiotic resistance in water containing orna- Cefazolin-gentamicin mental fishes, 598 synergism against enterococci, 157 Clindamycin Ceftezole compared with josamycin and rosamicin, 773 in vitro and in vivo evaluatidn, 1 comparison withjosamycin and rosamicin against Cell wall-inhibitory antibiotics B. fragilis, 188 suppression of lytic and bactericidal effects, 697 effect on aminoglycoside activity in a murine Cephalosporin model ofE. coli infection, 893 concentrations in peritoneal capsular fluid in rab- Coliform bacteria bits, 902 evolution oftransferable antibiotic resistance, 567 derivative, ceftezole, 1 Cytomegalovirus dual-action, 249 effect of ribavirin on infection, 809 vi SUBJECTINDEX ANTIMICROB. AGENTS CHEMOTHER. Doxycycline activity in vitro as compared with Sch 20656, ne- effects in actively purging cholera patients, 610 tilmicin, and tobramycin, 382 association in rises in blood urea nitrogen, 80 Encephalomyocarditis virus combined with ticarcillin as therapy in granulocy- treatment with exogenous interferon, polyinosinic topenic cancer patients, 837 acid-polycytidylic acid, or polyinosinic acid-po- effect on growth ofviral, chlamydial, and rickett- lycytidylic acid-poly-L-lysine complex on infec- sial agents in mice and embryonated eggs, 344 tions in mice, 668 in vitro comparison with tobramycin, sisomicin, Enteric fever and netilmicin, 768 cefazolin treatment, 52 nephrotoxicity as compared with netilmicin, 845 Enterobacteriaceae renal extraction in anesthetized dogs, 277 antibacterial activity of nine cephalosporins, 657 stability in serum, 866 comparative activity of netilmicin, gentamicin, susceptibility ofS. aureus strains, 707 amikacin, and tobramycin, 592 synergistic activity in combination with gentami- susceptibility to netilmicin and aminoglycoside cin in experimentalPseudomonas bacteremia in antibiotics, 677 neutropenic rats, 646 Erythromycin Gentamicin-carbenicillin compared with josamycin and rosamicin, 773 nosocomial infection with resistant P. aeruginosa, comparison withjosamycin and rosamicin against 626 B. fragilis, 188 Glutarimide comparison with josamycin in the therapy of M. new antibiotic, 9-methylstreptimidone, 14 pneumoniae pneumonia, 899 Gramicidin S Erythromycin stearate nutrition ofB. brevis ATCC 9999, the producer of, pharmacology compared with josamycin, 450 265 Escherichia coli ability of seven cephalosporins to penetrate the Haemophilus influenzae surface layers, 219 new method for detecting inactivation of penicil- actions of tetracyclines as studied by microcalo- lins, 564 rimetry, 604 Haemophilus influenzae type b correlation of resistance to proflavine and penicil- susceptibility to cefatrizine, ampicillin, and chlor- lin, 765 amphenicol, 322 effect of clindamycin on aminoglycoside activity Herpes simplex keratitis in a murine model of infection, 893 effect of 9-,8-n-arabinofuranosyladenine 5'-mono- effect ofosmolality on the response to mecillinam, phosphate and 9-,8-D-arabinofuranosylhypoxan- 824 thine 5'-monophosphate, 885 penetration of beta-lactamase-nonsusceptible Herpes simplex virus penicillins and cephalosporins, 215 antiviral activity of arabinosyladenine and ara- tetracycline action, 223 binosylhypoxanthine in infected KB cells, 64 Escherichia coli B inactivation by hydroxyquinolines, 234 phleomycin-induced solubilization of deoxyribo- photoinactivation in rabbit kidney cells, 229 nucleic acid in uninfected and T-bacteriophage- specific inactivation by silver nitrate, 57 infected, 150 Herpes simplex virus type 1 Escherichia coli K-12 differential effects of 5-methylmercapto-2'-deox- nalidixic acid inhibition of post-ultraviolet recov- yuridine on replication, 682 ery, 182 Herpes simplex virus type 2 specific action of 4-nitropyridine 1-oxide on Pro+ antiviral effect ofpyran against infection in mice, strains, 325, 333 28 5-Ethyl-deoxyuridine Hydroxyquinolines antiviral action and cellular toxicity, 119 inhibition of ribonucleic acid-dependent deoxyri- Experimental surgical-wound infections bonucleic acid polymerase and inactivation of characterization and quantitation in evaluating Rous sarcoma virus and herpes simplex virus, topical antibacterial agents, 38 234 responsiveness to topical chemotherapy, 45 Influenza virus Flumequine therapeutic effects of ribavirin in mice, 549 bioevaluation for urinary tract use, 20 Interferon effect of treatment on encephalomyocarditis virus Gentamicin infections in mitne, 668 activity against bacteria associated with intra- Isoxazolylpenicillins abdominal sepsis, 34 active metabolites in humans, 441 activity againstP. aeruginosa andEnterobacteria- ceae, 592 Josamycin activity alone and in combination with carbenicil- activity against B. fragilis, in vitro, 188 lin against S. marcescens, 878 compared with erythromycin and clindamycin, activity as compared with sisomicin in mouse pro- 773 tection tests with gram-negative bacilli, 384 comparison with erythromycin in the therapy of VOL. 10, 1976 SUBJECT INDEX Vii M. pneumoniae pneumonia, 899 Nalidixic acid pharmacology compared with erythromycin compared in vitro with cinoxacin and oxolinic stearate, 450 acid, 918 susceptibility of common clinical isolates, 253 inhibition ofpost-ultraviolet recovery inE. coli K- 12, 182 Kanamycin Neisseria gonorrhoeae comparative pharmacology with amikacin in 45 absence of penicillin-degrading enzymes in peni- neonates, 205 cillin-resistant strains, 179 Klebsiella species bacteriocin production, 417 antibiotic synergy and antagonism against clini- inhibition by a bacteriocin from P. aeruginosa, cal isolates, 889 354 multiple antibiotic resistance in clinical strains L5178Y cells isolated in South Carolina, 639 inhibition by methotrexate and antibiotics, 185 Neisseria meningitidis Lactobacilli reevaluation of the disk diffusion method for sul- effect of long-term therapies with penicillin and fonamide susceptibility testing, 869 sulfadiazine in dental plaque, 200 Neomycin influence when combined with oxytetracycline on Mannitol S. typhimurium, 89 inability in reducing amphotericin B nephrotoxic- Nephritis ity, 555 related to tuberculosis chemotherapy, 164 Mecillinam Netilmicin effect of osmolality on the response ofE. coli, 824 activity againstP. aeruginosa and Enterobacteria- epidemiology of bacterial resistance, 872 ceae, 592 synergy combined with beta-lactam antibiotics, activity alone and in combination with carbenicil- 535 lin against S. marcescens, 878 Melanin activity in vitro as compared with Sch 20656, gen- inhibition of antibiotic activity, 569 tamicin, and tobramycin, 382 Metallic ions biological activity, 827 antifungal properties, 856 compared with sisomicin in susceptibility testing, Methicillin 864 genotypic stability of resistance in S. aureus at in vitro comparison with four other aminoglyco- supraoptimal temperature, 377 side antibiotics, 139 short-term storage in microdilution trays for anti- in vitro comparison with gentamicin, tobramycin, microbial susceptibility tests, 83 and sisomicin, 768 Methotrexate in vitro study compared with other aminoglyco- inhibition of L5178Y cells in culture, 185 sides, 526 5-Methylmercapto-2'-deoxyuridine nephrotoxicity as compared with gentamicin in differential effects on replication of herpes sim- rats, 845 plex virus type 1, 682 susceptibility of gentamicin-resistant Enterobac- 9-Methylstreptimidone teriaceae andP. aeruginosa, 677 antiviral and interferon-inducing activity, 14 synergistic effect, 511 Metronidazole Nitroimidazoles antitrichomonad action, mutagenicity, and reduc- antitrichomonad action, mutagenicity, and reduction, 476 tion, 476 comparison withjosamycin and rosamicin against 4-Nitropyridine 1-oxide B. fragilis, 188 mechanism of action, 333 Miconazole specific action on E. coli K-12 Pro+ strains, 325, therapy of thrombocytosis and anemia, 447 333 Minocycline activity against bacteria associated with intra- Oxacillin abdominal sepsis, 34 short-term storage in microdilution trays for anti- susceptibility of A. calcoaceticus var. antitratus, microbial susceptibility tests, 83 102 susceptibility of S. aureus strains, 707 Murine coccidioidomycosis Oxolinic acid treatment with polymyxin B, 318 compared in vitro with cinoxacin and nalidixic Mycoplasma pneumoniae acid, 918 comparison ofjosamycin and erythromycin in the Oxytetracycline therapy of pneumonia, 899 influence when combined with neomycin on S. typhimurium, 89 Naegleria species susceptibility to a variety of therapeutic agents, Parainfluenza (Sendai) virus 370 therapeutic effects of small-particle aerosols of ri- Nafcillin bavirin on infections of mice, 770 short-term storage in microdilution trays for an- Penicillin timicrobial susceptibility tests, 83 absence of degrading enzymes in resistantN. gon- viii SUBJECT INDEX ANTIMICROB. AGENTS CHZMOTHER. orrhoeae strains, 179 lin-resistant, 626 correlation of resistance in E. coli, 765 susceptibility to netilmicin and aminoglycoside effect of long-term therapy on S. mutans and lac- antibiotics, 677 tobacilli in dental plaque, 200 Pyran effects of low concentrations on S. mutans, 196 antiviral effect against herpes simplex virus type lack of significant in vitro antagonism with ceph- 2 infection in mice, 28 alothin and rolitetracycline, 802 preparation of intestinal villi useful for studying recBC hydrolysis rates of esters, 861 nalidixic acid inhibition requirement for function, Penicillinase- 182 inducible oxacillin-hydrolyzing, 191 Resistance Penicillin G C. freundii to antibiotics, 598 change in susceptibility of group B streptococci R factor from 1968 through 1975, 380 mediation of antibiotic resistance in S. marces- Penicillins cens, 123 mode of action in B. megaterium, 579 Ribavirin new method for detecting inactivation byH. influ- effect on murine cytomegalovirus infection, 809 enzae and S. aureus, 564 therapeutic effects against influenza virus infec- penetration in E. coli of beta-lactamase-nonsus- tions in mice, 549 ceptible, 215 therapeutic effects of small-particle aerosols on susceptibility of respiratory tract anaerobes, 713 parainfluenza (Sendai) virus infections ofmice, Phleomycin 770 solubilization ofdeoxyribonucleic acid inE. coli B, Ribonucleic acid-dependent deoxyribonucleic acid 150 polymerase Physarum gyrosum inhibition by hydroxyquinolines, 234 growth on agar plates and in liquid culture, 613 Ribonucleic acid polymerase Pipemidic acid inhibition by tirandamycin, 618 inhibition of corjugal transfer of R plasmids, 779 Rolitetracycline Pirbenicillin lack of significant in vitro antagonism with peni- pharmacokinetic parameters in mice, 491 cillin and cephalothin, 802 Polyinosinic acid-polycytidylic acid Rosamicin effect of treatment on encephalomyocarditis virus activity against B. fragilis, in vitro, 188 infections in mice, 668 compared with erythromycin and cindamycin, Polyinosinic acid-polycytidylic acid-poly-L-lysine 773 complex Rous sarcoma virus effect of treatment on encephalomyocarditis virus inactivation by hydroxyquinolines, 234 infections in mice, 668 R-plasmid Polymyxin B transfer in vivo in the absence of antibiotic selec- treatment of murine coccidioidomycosis, 318 tion pressure, 753 Proflavine R plasmids correlation of resistance in E. coli, 765 classification by incompatibility inP. aeruginosa, Propionibacterium acnes 573 antimicrobial susceptibility, 387 inhibition of bacteriophage lambda, Ti, and T7 5-Propyl-deoxyuridine development, 762 antiviral action and cellular toxicity, 119 inhibition of conjugal transfer by pipemidic acid Proteus and related compounds, 779 effect of organic mercurials and sulfhydryl com- S. agalactiae (group B), 795 pounds on urease activity, 503 Prototheca species Saccharomyces cerevisiae susceptibility to antifungal agents, 75 inhibition of synthesis rate ofcarboxypeptidase Y Pseudomonas by tunicamycin, 402 synergistic activity of carbenicillin and gentami- Salmonella typhimurium cin in bacteremia in neutropenic rats, 646 influence of a combination of neomycin and oxy- Pseudomonas aeruginosa tetracycline, 89 activity of newer aminoglycosides and carbenicil- Sch 20656 lin against gentamicin-resistant, 399 activity in vitro as compared with netilmicin, gen- classification of R plasmids by incompatibility, tamicin, and tobramycin, 382 573 Serratia marcescens comparative activity of netilmicin, gentamicin, activity of gentamicin, amikacin, and netilmicin amikacin, and tobramycin, 592 alone and in combination, 878 inhibition ofN. gonorrhoeae by a bacteriocin, 354 R factor-mediated antibiotic resistance, 123 mutants that show specific hypersensitivity to Sisomicin aminoglycosides, 411 activity as compared with gentamicin in mouse nosocomial infection with gentamicin-carbenicil- protection tests with gram-negative bacilli, 384 VOL. 10, 1976 SUBJECT INDEX ix compared with netilmicin in susceptibility test- Talampicillin ing, 864 triple crossover study on absorption and excre- in vitro comparison ofnetilmicin, a semisynthetic tion, 173 derivative, 139 Tetracycline in vitro comparison with gentamicin, tobramycin, comparison of action on S. aureus and E. coli by and netilmicin, 768 microbial kinetics, 223 pharmacokinetic parameters, 25 Tetracyclines Staphylococcus aureus actions on E. coli as studied by microcalorimetry, cultivation in a synthetic medium of low ultravi- 604 olet absorptivity, 915 mediation of photoinactivation of Venezuelan genotypic stability ofmethicillin resistance at sut equine encephalitis virus, 176 praoptimal temperature, 377 3-(5-Tetrazolyl)penam new method for detecting inactivation of penicil- laboratory evaluation, 132 lins, 564 Thioglycolate broth disk method nucleotidylation of aminoglycoside antibiotics, antibiotic susceptibility testing of anaerobes, 727' 258 Thrombocytosis strains displaying unusual resistance to amino- reversibility due to miconazole therapy, 447 glycosides, 519 Thrombophlebitis susceptibility of strains to oxacillin, cephalothin, comparison associated with three cephalosporin and gentamicin, 707 antibiotics, 467 tetracycline action, 223 Ticarcillin Streptococcal L-forms activity in vitro as compared with BL-P1654 and bacteriocin production by group A, 912 carbenicillin, 241 Streptococci combined with cephalothin or gentamicin as ther- antimicrobial susceptibility of group B, 128 apy in granulocytopenic cancer patients, 837 change in susceptibility of group B to penicillin G Tirandamycin from 1968 through 1975, 380 inhibition of bacterial ribonucleic acid polymer- Streptococcin A-FF22 ase, 618 genetic basis of production, 299 Tobramycin Streptococcus agalactiae (group B) activity againstP. aeruginosa andEnterobacteria- R plasmids, 795 ceae, 592 Streptococcus mutans activity in vitro as compared with Sch 20656, ne- effect of long-term therapies with penicillin and tilmicin, and gentamicin, 382 sulfadiazine, 200 in vitro comparison with gentamicin, sisomicin, effects of low concentrations of penicillin and sul- and netilmicin, 768 fadiazine, 196 radioimmunoassay of iodinated, 652 susceptibility to antimicrobial agents, 274 Trimethoprim-sulfamethoxazole Sulfadiazine concentrations in blood after a single, large oral effect of long-term therapy on S. mutans and lac- dose, 462 tobacilli in dental plaque, 200 Tunicamycin effects of low concentrations on S. mutans, 196 inhibition of synthesis rate of carboxypeptidase Y Sulfonamide in S. cerevisiae, 402 reevaluation of the disk diffusion method for susceptibility testing ofN. meningitidis, 869 Venezuelan equine encephalitis virus Susceptibility photoinactivation mediated by tetracyclines, 176 anaerobic bacteria to 23 antimicrobial agents, 736 Verdamicin procedure for expediting determinations in gram- formation of methylated and phosphorylated me- negative, urinary tract pathogens, 921 tabolites during the fermentation process, 363 Susceptibility testing 5-Vinyl-deoxyuridine chemically defined medium, 923 antiviral action and cellular toxicity, 119 comparison of direct and standardized antimicro- Virazole bial tests, 211 antiviral effects in chronic hepatitis B surface medium for use with anaerobic bacteria, 926 antigen-seropositive chimpanzees, 571 of anaerobic bacteria with 100-ug carbenicillin disks, 112 Yoshida ascites sarcoma cells reproducibility of control strains, 436 mode of action of a purified antitumor protein sisomicin versus netilmicin, 864 from the proteinaceous crystal of B. thuringi- turbidimetric technique for yeasts, 721 ensis subsp. thuringiensis, 293 INDEX TO DATE OF ISSUE

Month Date of Issue Pages

July 22 July 1976 -1-190 August 23 August 1976 191-386 September 23 September 1976 387-572 October 19 October 1976 573-778 November 16 November 1976 779-867 December 14 December 1976 869-929 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VOLUME 10

WASHINGTON, D.C. 20006

1976 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VOLUME 10 * 1976 EDITORIAL BOARD GLADYS L. HOBBY, Editor-in-Chief (1980) U.S. Veterans Administration and the Infectious Disease Research Institute, East Orange, N.J. WALTER D. CELMER, Editor (1980) EDWARD W. HOOK, Editor (1981) Pfizer Inc., Groton, Conn. University of Virginia, Charlottesville JOEL G. FLAKS, Editor (1981) LEON H. SCHMIDT, Editor (1979) University ofPennsylvania, Philadelphia Southern Research Institute, Birmingham, Ala.