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November 2015 Asbmb Today 1 President’S Message

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November 2015 Asbmb Today 1 President’S Message Search for Editor-in-Chief The American Society for Biochemistry and Molecular Biology welcomes nominations and applications for the position of editor-in-chief of the Journal of Biological Chemistry. The JBC publishes original research that makes novel and important contributions to the study of the molecular and cellular bases of biological processes. The next editor-in-chief should be a public-facing thought leader, a committed advocate for authors and readers, a leader who listens and delegates, and an active researcher of significant accomplishment. Candidates should possess: • broad, general knowledge of biological chemistry; • strategic planning experience; • a commitment to publishing the very best science; • an appreciation for data-driven decision making; • the ability and desire to recruit outstanding scientists to serve as contributors, associate editors and editorial board members; • a willingness to provide sustained and consistent editorial direction; • proven interpersonal, communication, leadership and coalition–building skills; • financial and business prowess; and • scientific editorial experience. The editor-in-chief will: • provide visionary strategic direction, • act as the steward of the journal’s scientific content; • report results and next steps to ASBMB executives and elected leadership; • establish and refine journal policies and editorial guidelines; • lead inclusive, productive meetings for board members and associate editors; • respond to media requests; • collaborate with staff members and vendors; • represent the journal at meetings and other venues; and • write quarterly (or more frequent) editorials. The editor-in-chief will serve a five-year term, with the possibility of reappointment. The ASBMB will provide administrative support and a stipend. A search committee appointed by the president of the ASBMB will review nominations and applications. An application package should include a cover letter, a one-page vision for the journal and a CV (of no more than four pages) highlighting relevant experience and achievements. Send nominations and applications by Jan. 1, 2016, to the ASBMB Editor-in-Chief Search Committee c/o ASBMB Senior Director of Publications and Content Development Nancy Rodnan ([email protected]). CONTENTS NEWS FEATURES PERSPECTIVES 2 16 28 PRESIDENT’S MESSAGE SCIENCE ON A VISA CAREER INSIGHTS Getting it right Messages on bottles 24 4 MEET KATHRYN J. MOORE 31 NEWS FROM THE HILL HOBBIES Next-generation researchers 31 Eyes everywhere! find allies on the Hill 26 STEAM 32 Science and spices 5 The Petri painter 36 NEWS 16 Four ASBMB members win Nobel prizes OUTREACH Rajendrani 36 What you need to know Mukhopadhyay about the HOPES program writes about 6 the visa and 38 Community, suds and science MEMBER UPDATE immigration IN MEMORIAM process facing foreign-born 40 8 scientists. OPEN CHANNELS RETROSPECTIVE John A. Glomset 28 (1928 – 2015) 26 10 NEWS 10 Classifying pancreatic tumors 11 JOURNAL NEWS 11 Regulating fatty tissue 12 Actions of iron-dependent dioxygenases 13 Digging into grass sickness 14 Reproductive assist 14 Pulling apart the cytoskeleton 10 31 NOVEMBER 2015 ASBMB TODAY 1 PRESIDENT’S MESSAGE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Getting it right By Steven McKnight OFFICERS COUNCIL MEMBERS Steven McKnight Squire J. Booker President Karen G. Fleming Gregory Gatto Jr. omewhere around 30 years ago, the review group recognized that the Natalie Ahn Rachel Green a young scientist sent a grant science might hold great promise. President-Elect Susan Marqusee application to the National The applicant was James Allison. Karen Allen Jared Rutter S Secretary Brenda Schulman Insitutes of Health. The scientist His antibodies were recognizing the Michael Summers worked at an obscure research center T-cell receptor — which, of course, Toni Antalis Treasurer ASBMB TODAY EDITORIAL in Smithville, Texas — an institution varies from T cell to T cell in order ADVISORY BOARD as far as imaginable from being elite. to establish specificity for that arm of EX-OFFICIO MEMBERS Charles Brenner The grant proposal dealt with a series the immune-response pathway. The Squire Booker Chair of antibodies made by the applicant reviewer was Marian Koshland. The Wei Yang Michael Bradley Co-chairs, 2016 Annual Floyd “Ski” Chilton to T cells of the immune system. The grant was funded. Koshland was Meeting Program Cristy Gelling pattern of reactivity of the antibodies so impressed with the application Committee Peter J. Kennelly was weird, giving evidence that differ- that she and her colleagues recruited Peter J. Kennelly Rajini Rao ent T cells had surprisingly variable Allison from Texas to the Univer- Chair, Education and Yolanda Sanchez Professional Development Shiladitya Sengupta patterns of reactivity to the panel sity of California, Berkeley. There, Committee Carol Shoulders of antibodies. Irrespective of the Allison studied the pathways control- Daniel Raben weirdness of the science, the young ling T-cell activation, helping him ASBMB TODAY Chair, Meetings Committee age of the applicant, and the obscure to co-discover that a T-cell protein Angela Hopp Takita Felder Sumter Executive Editor, nature of the institution to which the called CTLA4 normally dampens the Chair, Minority Affairs [email protected] Committee applicant was affiliated, a member of immune response pathway. While at Lauren Dockett Thomas Baldwin Managing Editor, Chair, Outreach Committee [email protected] Wes Sundquist Rajendrani Mukhopadhyay Chair, Public Affairs Chief Science Correspondent, Advisory Committee [email protected] Blake Hill Valery Masterson Chair, Publications Designer, Committee [email protected] Lauri Pantos F. Peter Guengerich Manager of Publications Interim editor-in-chief, JBC Technology, [email protected] Herbert Tabor Ciarán Finn Co-editor, JBC Web Publication Assistant, [email protected] A. L. Burlingame Editor, MCP Allison Frick Media Specialist, Edward A. Dennis [email protected] Joseph L. Witztum Barbara Gordon Co-editors, JLR Executive Director, [email protected] For information on advertising, contact Pharmaceutical Media Inc. at 212-904-0374 or [email protected]. www.asbmb.org/asbmbtoday PRINT ISSN 2372-0409 Articles published in ASBMB Today reflect solely the authors’ views and not the official positions of the American Society for Biochemistry and Molecular Biology or the institutions with which the authors are affiliated. Mentions of products or services are not endorsements. ©2015 ASBMB 2 ASBMB TODAY NOVEMBER 2015 UC Berkeley, Allison also began his simply studying fundamental biology. scientists working — when they hit it quest to discover therapeutic antibod- Second, Allison’s initial discovery of big — in obscurity. ies that might relieve the inhibitory merit came while he was working at How, I ask, can we communicate activity of CTLA4 and thereby stimu- an obscure research institution. One the need to preserve a culture that late the immune-response pathway. does not have to be in the imperial fosters individuality? How do we say Fast-forward, and we see that halls of science to make discoveries of to the people of power that the very Allison’s science has led to one of consequence. Third, the grant-review best way forward has no plan or blue- the biggest breakthroughs in cancer system was successful in sorting the print at all — other than the support treatment ever: the development of wheat from the chaff in its evaluation of creative scientists willing to risk therapeutic antibodies that assist the of Allison’s first grant application. their careers on problems of unknown immune systems of patients in clear- Who knows, if not for Koshland’s value? Without knowing what will ing away tumor cells. Allison was the eagle eye for scientific merit, mela- make the biggest difference, how do 2015 winner of the Lasker–DeBakey noma patients might not be benefiting we choose which projects to support? Clinical Medical Research Award. from Allison’s antibody to CTLA4. My wish is that more reviewers of What a wonderful story! Many members of the American grant applications would, as Koshland What nuggets of information can Society for Biochemistry and Molecu- did, put more value in unique ideas we learn from this story? First and lar Biology are basic scientists. We and approaches than trendiness and foremost — to me — is the fact that study in our small nooks and crannies predictability. Allison’s work dealt exclusively with at the outskirts of the huge biomedical basic science. He wanted no more industrial research complex. The com- Steven McKnight (steven. [email protected]) than to understand the weird observa- plex is often loud in its promises to is president of the American tion that different antibodies could deliver breakthrough therapies to the Society for Biochemistry and distinguish variation on the surfaces of most vexing of human diseases. Some Molecular Biology and chairman of the biochemistry department different T cells. He did not set out of the most profound of advances can at the University of Texas-Southwestern Medical to find treatments for cancer; he was often be traced to cottage industry Center at Dallas. NOVEMBER 2015 ASBMB TODAY 3 NEWS FROM THE HILL Next-generation researchers find allies on the Hill By Sarah K. Martin hen National Institutes of ducing legislation to protect the future without supporting and investing in Health Director Francis Col- of research, science and innovation the next generation of researchers.”
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