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Hemistry N E W S L E T T E R
University of Michigan Chemistry N E W S L E T T E R Letter from the Chair I am pleased to send greetings and to fullerene, was a very engaging keynote Contents highlight the activities of the Chemistry speaker for this event. Before his talk, the Department this past year. The Depart- Department was awarded a 2006 Citation Letter from the Chair ........................ 1 ment is continuing to make enormous for Chemical Breakthroughs from the Di- New Faculty ..................................... 3 strides towards accomplishing its goal of vision of the History of Chemistry of the becoming one of the top Chemistry De- American Chemical Society in recognition Faculty News.................................... 4 partments in the nation. The most recent of work by Moses Gomberg. Additionally, I 150th Birthday ...................................4 US News and World Report ranking of have enjoyed meeting departmental alumni Graduate Program News Chemistry Departments listed Michigan and alumnae as well as prospective faculty as 16th in the nation; the analytical cluster candidates at the University of Michigan Graduate Awards .......................... 7 was ranked 9th, biochemistry 13th, organic reception that is held at every American Graduate Degrees........................ 10 th th 13 , and inorganic 15 . These are the Chemical Society National meeting. Please GS Council News .........................12 highest rankings for these clusters in many plan on attending this reception at the next years. We anticipate that our standing in ACS meeting. Undergraduate Program News the community will continue to rise, in REU Program ...............................12 Over the past year the department has view of the tremendous success that we recruited Dr. Anne McNeil, an outstand- Undergraduate Awards ............... -
DNA Repair Systems Guardians of the Genome
GENERAL ARTICLE DNA Repair Systems Guardians of the Genome D N Rao and Yedu Prasad The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar to honour their accomplishments in the field of DNA repair. Ever since the discovery of DNA structure and their importance in the storage of genetic information, questions about their stability became pertinent. A molecule which is crucial for the de- velopment and propagation of an organism must be closely D N Rao is a professor at the monitored so that the genetic information is not corrupted. Department of Biochemistry, Thanks to the pioneering research work of Lindahl, Sancar, Indian Institute of Science, Modrich and their colleagues, we now have an holistic aware- Bengaluru. His research ness of how DNA damage occurs and how the damage is rec- work primarily focuses on DNA interacting proteins in tified in bacteria as well as in higher organisms including hu- prokaryotes. This includes man beings. A comprehensive understanding of DNA repair restriction-modification has proven crucial in the fight against cancer and other debil- systems, DNA repair proteins itating diseases. from pathogenic bacteria and and proteins involved in The genetic information that guides the development, metabolism horizontal gene transfer and and reproduction of all living organisms and many viruses resides DNA recombination. in the DNA. This biological information is stored in the DNA Yedu Prasad is a graduate molecule as combinations of sequences that are formed by purine student working on his PhD and pyrimidine bases attached to the deoxyribose sugar (Figure under the guidance of D N 1). -
N E W S I N B R I
N E W S I N B R I E F NOBEL PRIZE IN MEDICINE The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for elucidating At the height of the Vietnamese war, the common enemy of three different mechanisms by which errors occur in our DNA soldiers on either side of the battle lines was chloroquine- and the various mechanisms of DNA repair. In the 1970’s, resistant malaria. In 1964, the North Vietnamese Government Lindahl discovered that DNA undergoes regular decay and approached the Chinese leader Mao Tse Tung to find a damage. For example, cytosine loses an amino group to become solution to this deadly scourge. Mao immediately established uracil resulting in a mutation. Subsequently, he discovered an a military mission Project 523 with a main aim to discover a enzyme system called uracil-DNA glycosylase which corrects drug for resistant malaria. Youyou Tu was a phytochemist who this error. This process was called base excision repair. Aziz was in charge of the project. She and her team combed through Sancar discovered and cloned the gene for an enzyme called hundreds of old Chinese traditional medicine texts. Around photolyase which is critical in correcting DNA mutations caused 2000 chemicals extracted from various plants were evaluated. by high doses of UV exposure. He further went on to identify the Finally, they zeroed on to an extract of Artemesia annua L. exact chemical processes involved in this nucleotide excision also called Quinhao which was found to have excellent repair. Paul Modrich discovered the mechanism by which DNA antimalarial efficacy in a mouse model. -
Graduation 2013. Wednesday 17 July 2013 the University of Sheffield
Graduation 2013. Wednesday 17 July 2013 The University of Sheffield Your graduation day is a special day for you and your family, a day for celebrating your achievements and looking forward to a bright future. As a graduate of the University of Sheffield you have every reason to be proud. You are joining a long tradition of excellence stretching back more than 100 years. The University of Sheffield was founded with the amalgamation of the School of Medicine, Sheffield Technical School and Firth College. In 1905, we received a Royal Charter and Firth Court was officially opened by King Edward VII and Queen Alexandra. At that time, there were 363 students reading for degrees in arts, pure science, medicine and applied science. By the time of our centenary, there were over 25,000 students from more than 100 countries, across 70 academic departments. Today, a degree from Sheffield is recognised all over the world as a hallmark of academic excellence. We are proud of our graduates and we are confident that you will make a difference wherever you choose to build your future. With every generation of graduates, our university goes from strength to strength. This is the original fundraising poster from 1904/1905 which helped raise donations for the University of Sheffield. Over £50,000 (worth more than £15 million today) was donated by steelworkers, coal miners, factory workers and the people of Sheffield in penny donations to help found the University. A century on, the University is now rated as one of the top world universities – according to the Shanghai Jiao Tong Academic Ranking of World Universities. -
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PIPELINE Max Cochrane AD676 CRISIS Brighton sits along the southern coast of the UK, sea levels have been rising by 4mm each year, this is expected to increase over the next 20 to 50 years. Given Brighton is right on the coast, it is at higher risk of being overwhelmed. Climate central predicts huge sections of Sussex will be hit by annual coastal floodswithin 30 years, and by 2050 large portions will fall below sea level. 2030 a meteor strikes a glacier increasing the sea level rise by 40 feet submerging much of Brighton’s seafront. This unexpected rise causes numerous businesses to be affected as well as cause problems for Brighton as a tourist hotspot. In need to respond to the crisis and solve the tourism issue, Brighton council investigates potential solutions to turn the negative into a positive. Brighton sewers: SITE CONTEXT • Until mid 1800s, most of Brighton’s sewage drained into cesspools at the back of houses. The Hippodrome is located very close to the • 1860 the council orders the construction of a system that will seafront and entrance to the old Brighton sewer systems. deliver sewage into the sea. • 1874 a 48km long sewer system is built underneath Brighton. • Old tunnel that runs from Hove to Portobello still serves as an The Hippodrome sits on a slopped surface, being at emergency relief valve during heavy rain. around 50 feet above the sea level. Being not so far • In late 1990s, a wide storm water collection drain was from the sewage systems, copper pipes will carry the sea water to the Hippodrome by tapping into constructed. -
Aziz SANCAR WINS Nobel Prize
Advancing SCIENCE Aziz Sancar, 2015 Nobel laureate in chemistry extremely proud that he is a member of TWAS, and we offer him heartfelt congratulations.” Sharing the prize with Sancar are two other chemists who have made pioneering discoveries in gene repair: Swedish native Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in Hertfordshire, UK, and American Paul Modrich of the Howard Hughes Medical Institute and Duke University School of Medicine in North Carolina. “Systematic work” by the three researchers “has made a decisive contribution to the understanding of how the living cell functions, as well as providing knowledge about the AZIZ SANCAR molecular causes of several hereditary diseases and about mechanisms behind both cancer development and WINS NOBEL PRIZE aging,” the Royal Swedish Academy of Sciences said in announcing the prizes. by Edward W. Lempinen Sancar, 69, was born in Savur, a small town in southeastern Turkey. The Turkish-born DNA to remove the damaged genetic He was the seventh of eight children. code. His initial discoveries at Yale “My parents were both illiterate,” he scientist, elected to TWAS University in the United States focused said in a 2005 profile published in the in 1994, shares the 2015 on E. coli bacteria; more recently, at Proceedings of the National Academy the University of North Carolina in the of Sciences (USA), “but they valued the Nobel Prize in chemistry United States, he detailed the workings importance of education and did their of this DNA repair in humans. best to ensure that all of their children for research into DNA Sancar is the first native of Turkey to would receive some education.” repair. -
Metabolic Tracing of NAD Precursors Using Strategically Labelled Isotopes of NMN
A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Metabolic tracing of NAD+ precursors using strategically labelled isotopes of NMN by Lynn-Jee Kim Supervisors Dr. Lindsay E. Wu (Primary) Prof. David A. Sinclair (Joint-Primary) Dr. Lake-Ee Quek (Co-supervisor) School of Medical Sciences Faculty of Medicine Thesis/Dissertation Sheet Surname/Family Name: Kim Given Name/s: Lynn-Jee Abbreviation for degree as give in PhD the University calendar: Faculty: Faculty of Medicine School: School of Medical Sciences + Thesis Title: Metabolic tracing of NAD precursors using strategically labelled isotopes of NMN Abstract 350 words maximum: (PLEASE TYPE) Nicotinamide adenine dinucleotide (NAD+) is an important cofactor and substrate for hundreds of cellular processes involved in redox homeostasis, DNA damage repair and the stress response. NAD+ declines with biological ageing and in age-related diseases such as diabetes and strategies to restore intracellular NAD+ levels are emerging as a promising strategy to protect against metabolic dysfunction, treat age-related conditions and promote healthspan and longevity. One of the most effective ways to increase NAD+ is through pharmacological supplementation with NAD+ precursors such as nicotinamide mononucleotide (NMN) which can be orally delivered. Long term administration of NMN in mice mitigates age-related physiological decline and alleviates the pathophysiologies associated with a high fat diet- and age-induced diabetes. Despite such efforts, there are certain aspects of NMN metabolism that are poorly understood. In this thesis, the mechanisms involved in the utilisation and transport of orally administered NMN were investigated using strategically labelled isotopes of NMN and mass spectrometry. -
Nobel Special Issue of Chemical Physics Letters
Accepted Manuscript Editorial Nobel Special Issue of Chemical Physics Letters David Clary, Mitchio Okumura, Villy Sundstrom PII: S0009-2614(13)01325-0 DOI: http://dx.doi.org/10.1016/j.cplett.2013.10.045 Reference: CPLETT 31683 To appear in: Chemical Physics Letters Please cite this article as: D. Clary, M. Okumura, V. Sundstrom, Nobel Special Issue of Chemical Physics Letters, Chemical Physics Letters (2013), doi: http://dx.doi.org/10.1016/j.cplett.2013.10.045 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Nobel Special Issue of Chemical Physics Letters Editorial The hallmark of Chemical Physics Letters is the fast publication of urgent communications of the highest quality. It has not escaped our notice that this policy has allowed several of the breakthrough papers in chemistry to be published in our journal. Indeed, looking through Chemical Physics Letters over the last 42 years we found papers published by as many as 15 authors who went on subsequently to win the Nobel Prize in Chemistry for work linked to their articles. Furthermore, several of these papers were referenced in the Nobel citations. We thought our readers would find it of interest to see a collection of these papers brought together and introduced with summaries explaining their significance and written by the Nobelists themselves, close colleagues or editors of the journal. -
Celebrating the Work of Nobel Laureate Paul Modrich
SCIENCE CHINA Life Sciences • NEWS AND VIEWS • January 2016 Vol.59 No.1: 93–96 doi: 10.1007/s11427-015-4989-y Celebrating the work of Nobel Laureate Paul Modrich Guo-Min Li Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA Received December 8, 2015; accepted December 12, 2015; published online December 17, 2015 Citation: Li, G.M. (2016). Celebrating the work of Nobel Laureate Paul Modrich. Sci China Life Sci 59, 93–96. doi: 10.1007/s11427-015-4989-y On October 7, 2015, the Nobel Prize Committee announced that the 2015 Nobel Prize in Chemistry had been awarded jointly to Professors Paul Modrich, Tomas Lindahl and Aziz Sancar (Figure 1), each of whom made ground-breaking discoveries about the molecular mechanisms of DNA Re- pair. In one of life’s unpredictable turns, Paul was among the last individuals in his entire personal, professional and social network to learn of the Committee’s decision, be- cause Paul was very far “off-the-grid” at the time of the announcement. The news that he had been selected as a 2015 Nobel Laureate may have taken Paul by surprise, but Figure 1 (color online) Paul Modrich, Aziz Sancar and Tomas Lindahl share the 2015 Nobel Prize in Chemistry. The photo was taken at the Nobel it certainly was not a surprise to most, if not all, of Paul’s Award Ceremony on December 10, 2015, when professors Lindahl (left), colleagues, students, family and friends. -
4 Brangwyn Avenue BRIGHTON East Sussex BN1 8XG Section 1 Contents Contents
4 Brangwyn Avenue BRIGHTON East Sussex BN1 8XG Section 1 Contents Contents Section Contents 1 Index 2 Property Information Questionnaire 3 Energy Performance Certificate 4 Sales Statement 5 Land Register Title Plan 6 Land Register Individual Register 7 Local Enquiries 8 Water and Drainage Enquiries 9 Section 2 Index HOME INFORMATION PACK INDEX Address and Postcode 4 Brangwyn Avenue or BRIGHTON Plot Number BN1 8XG ABOUT THIS FORM: • Under the Home Information Pack (No. 2) Regulations 2007, you must include an index which lists all the documents included in your Home Information Pack. • You may use this form as an index. Required documents need to be included in all cases where relevant: authorised documents do not. Please seek professional advice if you are unsure about what to include in your Home Information Pack. • All the documents in your Home Information Pack must be listed in the index, whether or not they are required or authorised. • Where a document required by the Regulations is unavailable or unobtainable, the index should indicate that a required document is missing, which document it is and the reason why. • Where the document exists and can be obtained, the index should indicate the steps being taken to obtain it and the date by which you expect to obtain the document, updating this date if it changes. It should also indicate the reason for a delay or any likely delay. • The index to your Home Information Pack should be updated whenever the pack or a pack document is added or removed. • Someone can complete this form on behalf of a seller. -
Miller Fellow Focus
The Adolph C. and Mary Sprague Newsletter MILLER INSTITUTE Fall 2016 for Basic Research in Science Understanding Dark Energy and Neutrinos Inside this edition: from the South Pole Miller Fellow Focus 1-3 From the Executive Director 4 Miller Fellow Focus: Tijmen de Haan Call for Nominations 5 odern cosmology provides an 6 Mincredibly powerful description In the News of the universe we live in. The stan- 20th Annual Symposium 7 dard model of Big Bang cosmology 8 takes only a few assumptions about Next Steps & Birth Announcements the physical laws and initial condi- tions, and makes a wealth of predic- Call for Nominations: tions. As our techniques for measur- ing the large-scale properties of the Miller Research Fellowship universe improve, the observations are found to be consistent with the Nominations predictions of the standard model Deadline: Saturday, September 10, 2016 of Big Bang cosmology time and time again. However, several open ques- Miller Research Professorship tions remain. Applications e can also use our measure- Deadline: Thursday, September 15, 2016 n the late 1990s, we learned that the Wments of the expansion rate Iexpansion of the universe is current- and growth of structure in the uni- Visiting Miller Professorship ly accelerating. This is due to a mysteri- verse to determine the properties of Departmental Nominations ous type of energy cosmologists have its contents. Around the turn of the Deadline: Friday, September 16, 2016 termed dark energy. This discovery millenium, neutrinos, long thought to led to the 2011 Nobel Prize in Phys- be massless particles, were found to See page 5 for more details. -
The Swedish-Canadian Chamber of Commerce Golden Jubilee 1965
THE SWEDISH-CANADIAN CHAMBER OF COMMERCE GOLDEN50 JUBILEE 1965 - 2015 Table of Contents Greetings From Public Officials and Dignitaries 2 The Chamber 9 SCCC Board of Directors 2015 10 Meet Our Members 11 History of the Chamber 12 List of Chamber Chairs 1965 - 2015 13 Embassy Interviews 14 10 Swedish Innovations 18 The Nobel Prize - Awarding Great Minds 20 Economic Outlook: Sweden and Canada 22 Article: Alfa Laval 24 Interesting Facts About Sweden 28 Article: The Great Swedish Hockey Migration 30 SCCC Wide Range of Events and Activities 33 A View to the Future 34 Ottawa, 25 November 2015 Ottawa As the Ambassador of Sweden to Canada, I am pleased to extend my most sincere congratulations to the Swedish Canadian Chamber of Commerce on the celebration of its 50th year of excellent service to the Swedish-Canadian business community. Throughout the years the Embassy has enjoyed collaborating with the chamber and appreciated its dedication and enthusiasm for supporting Swedish-Canadian related business. I am pleased to extend sincere congratulations to the staff and members of the Ottawa, 25 November 2015 Swedish-Canadian Chamber of Commerce as you gather to celebrate its 50th anniversary. TheAs themembers Ambassador of the of Chamber Sweden representsto Canada, some I am ofpleased the most to extend my most sincere prosperouscongratulations and well managed to the Swedish Swedish Canadian and Canadian Chamber companies of Commerce which on the celebration The welfare of both our country and our world depends on the engagement, play a keyof roleits 50th in strengthening year of excellent the service long lasting to the Swedish-Canadiantrade relations as well business as community.