January 12, 2016 u vol. 113 u no. 2

From the Cover

E249 Drought impacts on California forests E172 Kinases and prostate cancer metastasis E229 Potassium channel and sour taste 262 Tuning protein reduction potential 380 Lipid target of autoreactive T cells

Contents

THIS WEEK IN PNAS Cover image: Pictured is a 3D image of 237 In This Issue the canopy water content (CWC) of trees in the Jasper Ridge Biological Preserve at Stanford University, with low and high LETTERS (ONLINE ONLY) water content shown in red and blue, respectively. Gregory P. Asner et al. E105 Is nitric oxide important for the diastolic phase of the lymphatic found that CWC decreased measurably contraction/relaxation cycle? for an estimated 10.6 million hectares of Michael J. Davis forest, containing up to 888 million large E106 Reply to Davis: Nitric oxide regulates lymphatic contractions trees, between 2011 and 2015, with 1 Christian Kunert, James W. Baish, Shan Liao, Timothy P. Padera, and Lance L. Munn million hectares experiencing greater E107 Lion populations may be declining in Africa but not as Bauer et al. suggest than 30% CWC loss. The results suggest Jason Riggio, Tim Caro, Luke Dollar, Sarah M. Durant, Andrew P. Jacobson, Christian Kiffner, that if drought conditions in California Stuart L. Pimm, and Rudi J. van Aarde continue, forests might undergo E109 Reply to Riggio et al.: Ongoing lion declines across most of Africa warrant substantial changes. See the article by urgent action Asner et al. on pages E249–E255. Image Hans Bauer, Guillaume Chapron, Kristin Nowell, Philipp Henschel, Paul Funston, Luke T. B. courtesy of Carnegie Airborne Hunter, David W. Macdonald, Stephanie M. Dloniak, and Craig Packer Observatory, Carnegie Institution for Science. SCIENCE AND CULTURE—How science intersects with culture 240 Kirigami and technology cut a fine figure, together Graham P. Collins

PROFILE 242 Profile of Tomas Lindahl, Paul Modrich, and Aziz Sancar, 2015 Nobel Laureates in Chemistry James E. Cleaver

COMMENTARIES 246 Sour taste finds closure in a potassium channel Rosemary C. Challis and Minghong Ma See companion article on page E229 248 A single protein redox ruler Rajneesh K. Bains and Jeffrey J. Warren See companion article on page 262

Free online through the PNAS open access option. PNAS u January 12, 2016 u vol. 113 u no. 2 u 3–6 Downloaded by guest on September 23, 2021 251 Phospholipid signals of microbial infection for the 298 Climate challenges, vulnerabilities, and food security human immune system Margaret C. Nelson, Scott E. Ingram, Andrew J. Dugmore, Mitchell Kronenberg and Meng Zhao Richard Streeter, Matthew A. Peeples, Thomas H. McGovern, Michelle Hegmon, Jette Arneborg, Keith W. Kintigh, Seth See companion article on page 380 Brewington, Katherine A. Spielmann, Ian A. Simpson, Colleen Strawhacker, Laura E. L. Comeau, Andrea Torvinen, Christian K. Madsen, George Hambrecht, and Konrad Smiarowski PNAS PLUS 254 Significance Statements PSYCHOLOGICAL AND COGNITIVE SCIENCES Brief statements written by the authors about the significance of their 304 Estimating the reliability of eyewitness identifications papers. from police lineups John T. Wixted, Laura Mickes, John C. Dunn, Steven E. Clark, and William Wells PHYSICAL SCIENCES 310 Ecology-driven stereotypes override race stereotypes Keelah E. G. Williams, Oliver Sng, and Steven L. Neuberg APPLIED PHYSICAL SCIENCES 257 Size-dependent control of colloid transport via solute 316 Thinking from God’s perspective decreases biased gradients in dead-end channels valuation of the life of a nonbeliever Sangwoo Shin, Eujin Um, Benedikt Sabass, Jesse T. Ault, Jeremy Ginges, Hammad Sheikh, Scott Atran, and Nichole Argo Mohammad Rahimi, Patrick B. Warren, and Howard A. Stone SUSTAINABILITY SCIENCE CHEMISTRY 344 Rates and drivers of mangrove deforestation in 262 Design of a single protein that spans the entire 2-V Southeast Asia, 2000–2012 range of physiological redox potentials Daniel R. Richards and Daniel A. Friess Parisa Hosseinzadeh, Nicholas M. Marshall, Kelly N. Chaco´n, Yang Yu, Mark J. Nilges, Siu Yee New, Stoyan A. Tashkov, Ninian J. Blackburn, and Yi Lu BIOLOGICAL SCIENCES See Commentary on page 248 ANTHROPOLOGY EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 292 Early Lapita skeletons from Vanuatu show Polynesian E110 Trace incorporation of heavy water reveals slow and craniofacial shape: Implications for Remote Oceanic heterogeneous pathogen growth rates in cystic settlement and Lapita origins fibrosis sputum Fre´de´rique Valentin, Florent De´troit, Matthew J. T. Spriggs, and Stuart Bedford Sebastian H. Kopf, Alex L. Sessions, Elise S. Cowley, Carmen Reyes, Lindsey Van Sambeek, Yang Hu, Victoria J. Orphan, Roberta Kato, and Dianne K. Newman BIOCHEMISTRY E117 An inhibitor of HIV-1 protease modulates constitutive ENGINEERING eIF2α dephosphorylation to trigger a specific 268 Ultrasensitive surface-enhanced Raman scattering integrated stress response detection in common fluids Aude De Gassart, Bojan Bujisic, Le´a Zaffalon, Laurent A. Shikuan Yang, Xianming Dai, Birgitt Boschitsch Stogin, Decosterd, Antonia Di Micco, Gianluca Frera, Re´my Tallant, and Tak-Sing Wong and Fabio Martinon 320 One-carbon chemistry of oxalate oxidoreductase PHYSICS captured by X-ray crystallography 274 Fluctuating fitness shapes the clone-size distribution Marcus I. Gibson, Percival Yang-Ting Chen, Aileen C. Johnson, of immune repertoires Elizabeth Pierce, Mehmet Can, Stephen W. Ragsdale, and Catherine L. Drennan Jonathan Desponds, Thierry Mora, and Aleksandra M. Walczak 280 Self-duality and a Hall-insulator phase near the BIOPHYSICS AND COMPUTATIONAL BIOLOGY superconductor-to-insulator transition in indium-oxide films E127 Protein structural and surface water rearrangement Nicholas P. Breznay, Myles A. Steiner, Steven Allan Kivelson, constitute major events in the earliest aggregation and Aharon Kapitulnik stages of tau Anna Pavlova, Chi-Yuan Cheng, Maia Kinnebrew, John Lew, Frederick W. Dahlquist, and Songi Han SUSTAINABILITY SCIENCE E137 Understanding TRPV1 activation by ligands: Insights 286 Benefits of mercury controls for the United States Amanda Giang and Noelle E. Selin from the binding modes of capsaicin and resiniferatoxin Khaled Elokely, Phanindra Velisetty, Lucie Delemotte, Eugene Palovcak, Michael L. Klein, Tibor Rohacs, SOCIAL SCIENCES and Vincenzo Carnevale 326 Distal substitutions drive divergent DNA specificity ANTHROPOLOGY among paralogous transcription factors through 292 Early Lapita skeletons from Vanuatu show Polynesian subdivision of conformational space craniofacial shape: Implications for Remote Oceanic William H. Hudson, Bradley R. Kossmann, Ian Mitchelle S. settlement and Lapita origins de Vera, Shih-Wei Chuo, Emily R. Weikum, Geeta N. Eick, Fre´de´rique Valentin, Florent De´troit, Matthew J. T. Spriggs, Joseph W. Thornton, Ivaylo N. Ivanov, Douglas J. Kojetin, and Stuart Bedford and Eric A. Ortlund

4 u www.pnas.org Contents Downloaded by guest on September 23, 2021 CELL BIOLOGY 380 Human autoreactive T cells recognize CD1b 332 CAMSAP3 orients the apical-to-basal polarity of and phospholipids microtubule arrays in epithelial cells Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Mika Toya, Saeko Kobayashi, Miwa Kawasaki, Go Shioi, Mari Cheng, Benjamin J. Wolf, Raju V. V. Tatituri, Adam P. Uldrich, Kaneko, Takashi Ishiuchi, Kazuyo Misaki, Wenxiang Meng, Giorgio Napolitani, Vincenzo Cerundolo, John D. Altman, Peter and Masatoshi Takeichi Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S. Besra, MichaelB.Brenner,DaleI.Godfrey,andD.BranchMoody 338 A mouse model for adult cardiac-specific gene SeeCommentaryonpage251 deletion with CRISPR/Cas9 Kelli J. Carroll, Catherine A. Makarewich, John McAnally, 386 IFT20 controls LAT recruitment to the immune synapse Douglas M. Anderson, Lorena Zentilin, Ning Liu, Mauro Giacca, and T-cell activation in vivo Rhonda Bassel-Duby, and Eric N. Olson Omar I. Vivar, Giulia Masi, Jean-Marie Carpier, Joao G. Magalhaes, Donatella Galgano, Gregory J. Pazour, Sebastian ENVIRONMENTAL SCIENCES Amigorena, Claire Hivroz, and Cosima T. Baldari 268 Ultrasensitive surface-enhanced Raman scattering detection in common fluids MEDICAL SCIENCES Shikuan Yang, Xianming Dai, Birgitt Boschitsch Stogin, E172 Functional screen identifies kinases driving prostate and Tak-Sing Wong cancer visceral and bone metastasis 344 Rates and drivers of mangrove deforestation in Claire M. Faltermeier, Justin M. Drake, Peter M. Clark, Bryan A. Southeast Asia, 2000–2012 Smith, Yang Zong, Carmen Volpe, Colleen Mathis, Colm Daniel R. Richards and Daniel A. Friess Morrissey, Brandon Castor, Jiaoti Huang, and Owen N. Witte

EVOLUTION MICROBIOLOGY 274 Fluctuating fitness shapes the clone-size distribution E110 Trace incorporation of heavy water reveals slow and of immune repertoires heterogeneous pathogen growth rates in cystic Jonathan Desponds, Thierry Mora, and Aleksandra M. Walczak fibrosis sputum 350 A ribosome-inactivating protein in a Drosophila Sebastian H. Kopf, Alex L. Sessions, Elise S. Cowley, Carmen defensive symbiont Reyes, Lindsey Van Sambeek, Yang Hu, Victoria J. Orphan, Phineas T. Hamilton, Fangni Peng, Martin J. Boulanger, Roberta Kato, and Dianne K. Newman and Steve J. Perlman E182 Biochemical evidence of a role for matrix trimerization 356 Evolutionary transformation of rod photoreceptors in in HIV-1 envelope glycoprotein incorporation the all-cone retina of a diurnal garter snake Philip R. Tedbury, Mariia Novikova, Sherimay D. Ablan, Ryan K. Schott, Johannes Mu¨ller, Clement G. Y. Yang, Nihar and Eric O. Freed Bhattacharyya, Natalie Chan, Mengshu Xu, James M. Morrow, E191 Structurally conserved erythrocyte-binding domain in Ana-Hermina Ghenu, Ellis R. Loew, Vincent Tropepe, Plasmodium provides a versatile scaffold for alternate and Belinda S. W. Chang receptor engagement 362 Evolution of maternal effect senescence Jakub Gruszczyk, Nicholas T. Y. Lim, Alicia Arnott, Wen-Qiang Jacob A. Moorad and Daniel H. Nussey He, Wang Nguitragool, Wanlapa Roobsoong, Yee-Foong Mok, James M. Murphy, Katherine R. Smith, Stuart Lee, Melanie Bahlo, Ivo Mueller, Alyssa E. Barry, and Wai-Hong Tham GENETICS E146 Chromosome position determines the success of E201 HIV-1 RNA genome dimerizes on the plasma double-strand break repair membrane in the presence of Gag protein Cheng-Sheng Lee, Ruoxi W. Wang, Hsiao-Han Chang, Daniel Jianbo Chen, Sheikh Abdul Rahman, Olga A. Nikolaitchik, David Capurso, Mark R. Segal, and James E. Haber Grunwald, Luca Sardo, Ryan C. Burdick, Sergey Plisov, Edward Liang, Sheldon Tai, Vinay K. Pathak, and Wei-Shau Hu 368 Neolithic and Bronze Age migration to Ireland and – establishment of the insular Atlantic genome E209 Mechanistic insights into c-di-GMP dependent Lara M. Cassidy, Rui Martiniano, Eileen M. Murphy, Matthew D. control of the biofilm regulator FleQ from Teasdale, James Mallory, Barrie Hartwell, and Daniel G. Bradley Pseudomonas aeruginosa Bruno Y. Matsuyama, Petya V. Krasteva, Claudine 374 A second transmissible cancer in Tasmanian devils Baraquet, Caroline S. Harwood, Holger Sondermann, Ruth J. Pye, David Pemberton, Cesar Tovar, Jose M. C. Tubio, and Marcos V. A. S. Navarro Karen A. Dun, Samantha Fox, Jocelyn Darby, Dane Hayes, Graeme W. Knowles, Alexandre Kreiss, Hannah V. T. Siddle, 392 Prevalence, genetics, and transmissibility in ferrets of Kate Swift, A. Bruce Lyons, Elizabeth P. Murchison, Eurasian avian-like H1N1 swine influenza viruses and Gregory M. Woods Huanliang Yang, Yan Chen, Chuanling Qiao, Xijun He, Hong Zhou, Yu Sun, Hang Yin, Shasha Meng, Liping Liu, Qianyi Zhang, IMMUNOLOGY AND INFLAMMATION Huihui Kong, Chunyang Gu, Chengjun Li, Zhigao Bu, Yoshihiro Kawaoka, and Hualan Chen E155 Critical role of RAGE and HMGB1 in inflammatory heart disease 398 Dissecting the interface between apicomplexan Anna Bangert, Martin Andrassy, Anna-Maria Mu¨ller, Mariella parasite and host cell: Insights from a divergent Bockstahler, Andrea Fischer, Christian H. Volz, Christoph Leib, AMA–RON2 pair Stefan Go¨ser, Sevil Korkmaz-Ico¨z, Stefan Zittrich, Andreas Michelle L. Parker, Diana M. Penarete-Vargas, Phineas T. Jungmann, Felix Lasitschka, Gabriele Pfitzer, Oliver J. Mu¨ller, Hamilton, Amandine Gue´rin, Jitender P. Dubey, Steve J. Hugo A. Katus, and Ziya Kaya Perlman, Furio Spano, Maryse Lebrun, and Martin J. Boulanger E165 Deubiquitinase CYLD acts as a negative regulator for 404 A cell wall damage response mediated by a sensor bacterium NTHi-induced inflammation by suppressing kinase/response regulator pair enables K63-linked ubiquitination of MyD88 beta-lactam tolerance Byung-Cheol Lee, Masanori Miyata, Jae Hyang Lim, Tobias Do¨rr, Laura Alvarez, Fernanda Delgado, Brigid M. Davis, and Jian-Dong Li Felipe Cava, and Matthew K. Waldor

Contents PNAS u January 12, 2016 u vol. 113 u no. 2 u 5 Downloaded by guest on September 23, 2021 410 Zinc-dependent mechanical properties of PLANT BIOLOGY Staphylococcus aureus biofilm-forming E239 In vitro reconstruction and analysis of evolutionary surface protein SasG variation of the tomato acylsucrose metabolic network Ce´cile Formosa-Dague, Pietro Speziale, Timothy J. Pengxiang Fan, Abigail M. Miller, Anthony L. Schilmiller, Foster, Joan A. Geoghegan, and Yves F. Dufreˆne Xiaoxiao Liu, Itai Ofner, A. Daniel Jones, Dani Zamir, and Robert L. Last NEUROSCIENCE 452 Actin-dependent vacuolar occupancy of the cell E219 Functional hierarchy underlies preferential determines auxin-induced growth repression connectivity disturbances in schizophrenia David Scheuring, Christian Lo¨fke, Falco Kru¨ger, Genevieve J. Yang, John D. Murray, Xiao-Jing Wang, David C. Maike Kittelmann, Ahmed Eisa, Louise Hughes, Glahn, Godfrey D. Pearlson, Grega Repovs, John H. Krystal, Richard S. Smith, Chris Hawes, Karin Schumacher, and Alan Anticevic and Ju¨rgen Kleine-Vehn 416 Feature-based face representations and image reconstruction from behavioral and neural data SUSTAINABILITY SCIENCE Adrian Nestor, David C. Plaut, and Marlene Behrmann E249 Progressive forest canopy water loss during the 422 Long-acting cocaine hydrolase for addiction therapy 2012–2015 California drought Xiabin Chen, Liu Xue, Shurong Hou, Zhenyu Jin, Ting Zhang, Gregory P. Asner, Philip G. Brodrick, Christopher B. Anderson, Fang Zheng, and Chang-Guo Zhan Nicholas Vaughn, David E. Knapp, and Roberta E. Martin 428 Metabolic connectivity mapping reveals effective 458 Drivers of household food availability in sub-Saharan connectivity in the resting human brain Africa based on big data from small farms Valentin Riedl, Lukas Utz, Gabriel Castrillo´n, Timo Grimmer, Romain Frelat, Santiago Lopez-Ridaura, Ken E. Giller, Mario Josef P. Rauschecker, Markus Ploner, Karl J. Friston, Alexander Herrero, Sabine Douxchamps, Agnes Andersson Djurfeldt, Olaf Drzezga, and Christian Sorg Erenstein, Ben Henderson, Menale Kassie, Birthe K. Paul, Cyrille Rigolot, Randall S. Ritzema, Daniel Rodriguez, Piet J. A. van PHARMACOLOGY Asten, and Mark T. van Wijk 434 Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways Nicholas S. Kirkby, Melissa V. Chan, Anne K. Zaiss, Eliana CORRECTION (ONLINE ONLY) Garcia-Vaz, Jing Jiao, Lisa M. Berglund, Elena F. Verdu, Blerina Ahmetaj-Shala, John L. Wallace, Harvey R. Herschman, Maria F. IMMUNOLOGY AND INFLAMMATION Gomez, and Jane A. Mitchell E256 Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3 PHYSIOLOGY + Dapeng Yan, Julia Farache, Diane Mathis, E229 The K channel KIR2.1 functions in tandem with and Christophe Benoist proton influx to mediate sour taste transduction Wenlei Ye, Rui B. Chang, Jeremy D. Bushman, Yu-Hsiang Tu, Eric M. Mulhall, Courtney E. Wilson, Alexander J. Cooper, Wallace S. Chick, David C. Hill-Eubanks, Mark T. Nelson, SI CORRECTION (ONLINE ONLY) Sue C. Kinnamon, and Emily R. Liman

See Commentary on page 246 EVOLUTION 440 Genetically targeted single-channel optical recording E257 Allopolyploidy, diversification, and the Miocene reveals multiple Orai1 gating states and oscillations grassland expansion in calcium influx Matt C. Estep, Michael R. McKain, Dilys Vela Diaz, Jinshun Joseph L. Dynes, Anna Amcheslavsky, and Michael D. Cahalan Zhong, John G. Hodge, Trevor R. Hodkinson, Daniel J. Layton, Simon T. Malcomber, Re´my Pasquet, 446 Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an and Elizabeth A. Kellogg effect on body weight Yong-Qi Li, Yogendra B. Shrestha, Min Chen, Tatyana Chanturiya, Oksana Gavrilova, and Lee S. Weinstein vii Subscription Form

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