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January 12, 2016 u vol. 113 u no. 2 From the Cover E249 Drought impacts on California forests E172 Kinases and prostate cancer metastasis E229 Potassium channel and sour taste 262 Tuning protein reduction potential 380 Lipid target of autoreactive T cells Contents THIS WEEK IN PNAS Cover image: Pictured is a 3D image of 237 In This Issue the canopy water content (CWC) of trees in the Jasper Ridge Biological Preserve at Stanford University, with low and high LETTERS (ONLINE ONLY) water content shown in red and blue, respectively. Gregory P. Asner et al. E105 Is nitric oxide important for the diastolic phase of the lymphatic found that CWC decreased measurably contraction/relaxation cycle? for an estimated 10.6 million hectares of Michael J. Davis forest, containing up to 888 million large E106 Reply to Davis: Nitric oxide regulates lymphatic contractions trees, between 2011 and 2015, with 1 Christian Kunert, James W. Baish, Shan Liao, Timothy P. Padera, and Lance L. Munn million hectares experiencing greater E107 Lion populations may be declining in Africa but not as Bauer et al. suggest than 30% CWC loss. The results suggest Jason Riggio, Tim Caro, Luke Dollar, Sarah M. Durant, Andrew P. Jacobson, Christian Kiffner, that if drought conditions in California Stuart L. Pimm, and Rudi J. van Aarde continue, forests might undergo E109 Reply to Riggio et al.: Ongoing lion declines across most of Africa warrant substantial changes. See the article by urgent action Asner et al. on pages E249–E255. Image Hans Bauer, Guillaume Chapron, Kristin Nowell, Philipp Henschel, Paul Funston, Luke T. B. courtesy of Carnegie Airborne Hunter, David W. Macdonald, Stephanie M. Dloniak, and Craig Packer Observatory, Carnegie Institution for Science. SCIENCE AND CULTURE—How science intersects with culture 240 Kirigami and technology cut a fine figure, together Graham P. Collins PROFILE 242 Profile of Tomas Lindahl, Paul Modrich, and Aziz Sancar, 2015 Nobel Laureates in Chemistry James E. Cleaver COMMENTARIES 246 Sour taste finds closure in a potassium channel Rosemary C. Challis and Minghong Ma See companion article on page E229 248 A single protein redox ruler Rajneesh K. Bains and Jeffrey J. Warren See companion article on page 262 Free online through the PNAS open access option. PNAS u January 12, 2016 u vol. 113 u no. 2 u 3–6 Downloaded by guest on September 23, 2021 251 Phospholipid signals of microbial infection for the 298 Climate challenges, vulnerabilities, and food security human immune system Margaret C. Nelson, Scott E. Ingram, Andrew J. Dugmore, Mitchell Kronenberg and Meng Zhao Richard Streeter, Matthew A. Peeples, Thomas H. McGovern, Michelle Hegmon, Jette Arneborg, Keith W. Kintigh, Seth See companion article on page 380 Brewington, Katherine A. Spielmann, Ian A. Simpson, Colleen Strawhacker, Laura E. L. Comeau, Andrea Torvinen, Christian K. Madsen, George Hambrecht, and Konrad Smiarowski PNAS PLUS 254 Significance Statements PSYCHOLOGICAL AND COGNITIVE SCIENCES Brief statements written by the authors about the significance of their 304 Estimating the reliability of eyewitness identifications papers. from police lineups John T. Wixted, Laura Mickes, John C. Dunn, Steven E. Clark, and William Wells PHYSICAL SCIENCES 310 Ecology-driven stereotypes override race stereotypes Keelah E. G. Williams, Oliver Sng, and Steven L. Neuberg APPLIED PHYSICAL SCIENCES 257 Size-dependent control of colloid transport via solute 316 Thinking from God’s perspective decreases biased gradients in dead-end channels valuation of the life of a nonbeliever Sangwoo Shin, Eujin Um, Benedikt Sabass, Jesse T. Ault, Jeremy Ginges, Hammad Sheikh, Scott Atran, and Nichole Argo Mohammad Rahimi, Patrick B. Warren, and Howard A. Stone SUSTAINABILITY SCIENCE CHEMISTRY 344 Rates and drivers of mangrove deforestation in 262 Design of a single protein that spans the entire 2-V Southeast Asia, 2000–2012 range of physiological redox potentials Daniel R. Richards and Daniel A. Friess Parisa Hosseinzadeh, Nicholas M. Marshall, Kelly N. Chaco´n, Yang Yu, Mark J. Nilges, Siu Yee New, Stoyan A. Tashkov, Ninian J. Blackburn, and Yi Lu BIOLOGICAL SCIENCES See Commentary on page 248 ANTHROPOLOGY EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 292 Early Lapita skeletons from Vanuatu show Polynesian E110 Trace incorporation of heavy water reveals slow and craniofacial shape: Implications for Remote Oceanic heterogeneous pathogen growth rates in cystic settlement and Lapita origins fibrosis sputum Fre´de´rique Valentin, Florent De´troit, Matthew J. T. Spriggs, and Stuart Bedford Sebastian H. Kopf, Alex L. Sessions, Elise S. Cowley, Carmen Reyes, Lindsey Van Sambeek, Yang Hu, Victoria J. Orphan, Roberta Kato, and Dianne K. Newman BIOCHEMISTRY E117 An inhibitor of HIV-1 protease modulates constitutive ENGINEERING eIF2α dephosphorylation to trigger a specific 268 Ultrasensitive surface-enhanced Raman scattering integrated stress response detection in common fluids Aude De Gassart, Bojan Bujisic, Le´a Zaffalon, Laurent A. Shikuan Yang, Xianming Dai, Birgitt Boschitsch Stogin, Decosterd, Antonia Di Micco, Gianluca Frera, Re´my Tallant, and Tak-Sing Wong and Fabio Martinon 320 One-carbon chemistry of oxalate oxidoreductase PHYSICS captured by X-ray crystallography 274 Fluctuating fitness shapes the clone-size distribution Marcus I. Gibson, Percival Yang-Ting Chen, Aileen C. Johnson, of immune repertoires Elizabeth Pierce, Mehmet Can, Stephen W. Ragsdale, and Catherine L. Drennan Jonathan Desponds, Thierry Mora, and Aleksandra M. Walczak 280 Self-duality and a Hall-insulator phase near the BIOPHYSICS AND COMPUTATIONAL BIOLOGY superconductor-to-insulator transition in indium-oxide films E127 Protein structural and surface water rearrangement Nicholas P. Breznay, Myles A. Steiner, Steven Allan Kivelson, constitute major events in the earliest aggregation and Aharon Kapitulnik stages of tau Anna Pavlova, Chi-Yuan Cheng, Maia Kinnebrew, John Lew, Frederick W. Dahlquist, and Songi Han SUSTAINABILITY SCIENCE E137 Understanding TRPV1 activation by ligands: Insights 286 Benefits of mercury controls for the United States Amanda Giang and Noelle E. Selin from the binding modes of capsaicin and resiniferatoxin Khaled Elokely, Phanindra Velisetty, Lucie Delemotte, Eugene Palovcak, Michael L. Klein, Tibor Rohacs, SOCIAL SCIENCES and Vincenzo Carnevale 326 Distal substitutions drive divergent DNA specificity ANTHROPOLOGY among paralogous transcription factors through 292 Early Lapita skeletons from Vanuatu show Polynesian subdivision of conformational space craniofacial shape: Implications for Remote Oceanic William H. Hudson, Bradley R. Kossmann, Ian Mitchelle S. settlement and Lapita origins de Vera, Shih-Wei Chuo, Emily R. Weikum, Geeta N. Eick, Fre´de´rique Valentin, Florent De´troit, Matthew J. T. Spriggs, Joseph W. Thornton, Ivaylo N. Ivanov, Douglas J. Kojetin, and Stuart Bedford and Eric A. Ortlund 4 u www.pnas.org Contents Downloaded by guest on September 23, 2021 CELL BIOLOGY 380 Human autoreactive T cells recognize CD1b 332 CAMSAP3 orients the apical-to-basal polarity of and phospholipids microtubule arrays in epithelial cells Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Mika Toya, Saeko Kobayashi, Miwa Kawasaki, Go Shioi, Mari Cheng, Benjamin J. Wolf, Raju V. V. Tatituri, Adam P. Uldrich, Kaneko, Takashi Ishiuchi, Kazuyo Misaki, Wenxiang Meng, Giorgio Napolitani, Vincenzo Cerundolo, John D. Altman, Peter and Masatoshi Takeichi Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S. Besra, MichaelB.Brenner,DaleI.Godfrey,andD.BranchMoody 338 A mouse model for adult cardiac-specific gene SeeCommentaryonpage251 deletion with CRISPR/Cas9 Kelli J. Carroll, Catherine A. Makarewich, John McAnally, 386 IFT20 controls LAT recruitment to the immune synapse Douglas M. Anderson, Lorena Zentilin, Ning Liu, Mauro Giacca, and T-cell activation in vivo Rhonda Bassel-Duby, and Eric N. Olson Omar I. Vivar, Giulia Masi, Jean-Marie Carpier, Joao G. Magalhaes, Donatella Galgano, Gregory J. Pazour, Sebastian ENVIRONMENTAL SCIENCES Amigorena, Claire Hivroz, and Cosima T. Baldari 268 Ultrasensitive surface-enhanced Raman scattering detection in common fluids MEDICAL SCIENCES Shikuan Yang, Xianming Dai, Birgitt Boschitsch Stogin, E172 Functional screen identifies kinases driving prostate and Tak-Sing Wong cancer visceral and bone metastasis 344 Rates and drivers of mangrove deforestation in Claire M. Faltermeier, Justin M. Drake, Peter M. Clark, Bryan A. Southeast Asia, 2000–2012 Smith, Yang Zong, Carmen Volpe, Colleen Mathis, Colm Daniel R. Richards and Daniel A. Friess Morrissey, Brandon Castor, Jiaoti Huang, and Owen N. Witte EVOLUTION MICROBIOLOGY 274 Fluctuating fitness shapes the clone-size distribution E110 Trace incorporation of heavy water reveals slow and of immune repertoires heterogeneous pathogen growth rates in cystic Jonathan Desponds, Thierry Mora, and Aleksandra M. Walczak fibrosis sputum 350 A ribosome-inactivating protein in a Drosophila Sebastian H. Kopf, Alex L. Sessions, Elise S. Cowley, Carmen defensive symbiont Reyes, Lindsey Van Sambeek, Yang Hu, Victoria J. Orphan, Phineas T. Hamilton, Fangni Peng, Martin J. Boulanger, Roberta Kato, and Dianne K. Newman and Steve J. Perlman E182 Biochemical evidence of a role for matrix trimerization 356 Evolutionary transformation of rod photoreceptors in in HIV-1 envelope glycoprotein incorporation the all-cone retina of a diurnal garter snake Philip R. Tedbury, Mariia Novikova, Sherimay D. Ablan, Ryan K. Schott, Johannes Mu¨ller, Clement G. Y.