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Regulated Substance List
INSTRUCTIONS FOR THE UNIFIED PROGRAM (UP) FORM REGULATED SUBSTANCE LIST CHEMICAL NAME CAS # TQ Listing CHEMICAL NAME CAS # TQ Listing (Lbs) Basis (Lbs) Basis Acetaldehyde 75-07-0 10,000 g Cantharidin 56-25-7 100/10,0001 * Acetone Cyanohydrin 75-86-5 1,000 Carbachol Chloride 51-83-2 500/10,0001 Acetone Thiosemicarbazide 1752-30-3 1,000/10,0001 Acetylene (Ethyne) 74-86-2 10,000 f Carbamic Acid, Methyl-,o- Acrolein (2-Propenal) 107-02-8 500 b (((2,4-Dimethyl-1,3-Dithiolan- Acrylamide 79-06-1 1,000/10,0001 2-YL) Methylene)Amino)- 26419-73-8 100/10,0001 Acrylonitrile (2- Propenenitrile) 107-13-1 10,000 b Carbofuran 1563-66-2 10/10,0001 Acrylyl Chloride Carbon Disulfide 75-15-0 10,000 b (2-Propenoyl Chloride) 814-68-6 100 b Carbon Oxysulfide Aldicarb 116-06-3 100/10,0001 (Carbon Oxide Sulfide (COS)) 463-58-1 10,000 f Aldrin 309-00-2 500/10,0001 Chlorine 7782-50-5 100 a,b Allyl Alcohol (2-Propen-1-ol) 107-18-6 1,000 b Chlorine Dioxide Allylamine (2-Propen-1-Amine) 107-11-9 500 b (Chlorine Oxide (ClO2)) 10049-04-4 1,000 c Aluminum Phosphide 20859-73-8 500 Chlorine Monoxide (Chlorine Oxide) 7791-21-1 10,000 f Aminopterin 54-62-6 500/10,0001 Chlormequat Chloride 999-81-5 100/10,0001 Amiton Oxalate 3734-97-2 100/10,0001 Chloroacetic Acid 79-11-8 100/10,0001 Ammonia, Anhydrous 2 7664-41-7 500 a,b Chloroform 67-66-3 10,000 b Ammonia, Aqueous Chloromethyl Ether (conc 20% or greater) 7664-41-7 20,000 a,b (Methane,Oxybis(chloro-) 542-88-1 100 b * Aniline 62-53-3 1,000 Chloromethyl Methyl Ether Antimycin A 1397-94-0 1,000/10,0001 (Chloromethoxymethane) -
Physical Study by Surface Characteriza4ons of Sarin Sensor on the Basis of Chem
Physical Study by Surface Characterizaons of Sarin Sensor on the Basis of Chemically Func4onalized Silicon Nanoribbon Field Effect Transistor K. Smaali1,§, D. Guérin1, V. Passi1, L. Ordronneau2, A. Carella2, T. Mélin1, E. Dubois1, D. Vuillaume1, J.P. Simonato2 and S. Lenfant1,* 1 IEMN, CNRS, Avenue Poincaré, Villeneuve d'Ascq, F-59652 cedex, France. 2. CEA, LITEN/DTNM/SEN/LSIN, Univ. Grenoble Alpes, MINATEC Campus, F-38054 Grenoble, France. ABSTRACT : Surface characteriZa[ons of an organophosphorus (OP) gas detector based on chemically func[onaliZed silicon nanoribbon field-effect transistor (SiNR-FET) were performed by Kelvin Probe Force Microscopy (KPFM) and ToF-SIMS, and correlated with changes in the current-voltage characteris[cs of the devices. KPFM measurements on FETs allow (i) to inves[gate the contact poten[al difference (CPD) distribu[on of the polariZed device as func[on of the gate voltage and the exposure to OP traces and; (ii) to analyZe the CPD hysteresis associated to the presence of mobile ions on the surface. The CPD measured by KPFM on the silicon nanoribbon was corrected due to side capacitance effects in order to determine the real quan[ta[ve surface poten[al. Comparison with macroscopic Kelvin probe (KP) experiments on larger surfaces was carried out. These two approaches were quan[ta[vely consistent. An important increase of the CPD values (between + 399 mV and + 302 mV) was observed aeer the OP sensor graeing, corresponding to a decrease of the work func[on, and a weaker varia[on aeer exposure to OP (between - 14 mV and - 61 mV) was measured. -
Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
Copyrighted Material
1 Historical Milieu 1.1 Organophosphorus Nerve Agents 2 1.2 Blister Agents 5 1.3 Sternutator Agents 11 1.4 Chemical Weapons Convention (CWC) 13 1.4.1 Schedule of Chemicals 14 1.4.2 Destruction of Chemical Weapons 14 References 16 COPYRIGHTED MATERIAL Analysis of Chemical Warfare Degradation Products, First Edition. Karolin K. Kroening, Renee N. Easter, Douglas D. Richardson, Stuart A. Willison and Joseph A. Caruso. © 2011 John Wiley & Sons, Ltd. Published 2011 by John Wiley & Sons, Ltd. 2 ANALYSIS OF CHEMICAL WARFARE DEGRADATION PRODUCTS 1.1 ORGANOPHOSPHORUS NERVE AGENTS Organophosphorus (OP) type compounds, that is, deriva- tives containing the P=O moiety, were first discovered in the 1800s when researchers were investigating useful applica- tions for insecticides/rodenticides. There are many derivatives of organophosphorus compounds, however, the OP deriva- tives that are typically known as ‘nerve agents’ were discov- ered accidentally in Germany in 1936 by a research team led by Dr. Gerhard Schrader at IG Farben [1–4]. Schrader had noticed the effects and lethality of these organophosphorus compounds towards insects and began developing a new class of insecticides. While working towards the goal of an improved insecticide, Schrader experimented with numerous phosphorus-containing compounds, leading to the discovery of the first nerve agent, Tabun (or GA) (Figure 1.1). The potency of these insecticides towards humans was not realized until there was yet another accident, which involved a Tabun spill. Schrader and coworkers began experiencing symptoms, such as miosis (constriction of the pupils of the eyes), dizziness and severe shortness of breath, with numerous effects lasting several weeks [1, 4, 5]. -
Biological Toxins As the Potential Tools for Bioterrorism
International Journal of Molecular Sciences Review Biological Toxins as the Potential Tools for Bioterrorism Edyta Janik 1, Michal Ceremuga 2, Joanna Saluk-Bijak 1 and Michal Bijak 1,* 1 Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland; [email protected] (E.J.); [email protected] (J.S.-B.) 2 CBRN Reconnaissance and Decontamination Department, Military Institute of Chemistry and Radiometry, Antoniego Chrusciela “Montera” 105, 00-910 Warsaw, Poland; [email protected] * Correspondence: [email protected] or [email protected]; Tel.: +48-(0)426354336 Received: 3 February 2019; Accepted: 3 March 2019; Published: 8 March 2019 Abstract: Biological toxins are a heterogeneous group produced by living organisms. One dictionary defines them as “Chemicals produced by living organisms that have toxic properties for another organism”. Toxins are very attractive to terrorists for use in acts of bioterrorism. The first reason is that many biological toxins can be obtained very easily. Simple bacterial culturing systems and extraction equipment dedicated to plant toxins are cheap and easily available, and can even be constructed at home. Many toxins affect the nervous systems of mammals by interfering with the transmission of nerve impulses, which gives them their high potential in bioterrorist attacks. Others are responsible for blockage of main cellular metabolism, causing cellular death. Moreover, most toxins act very quickly and are lethal in low doses (LD50 < 25 mg/kg), which are very often lower than chemical warfare agents. For these reasons we decided to prepare this review paper which main aim is to present the high potential of biological toxins as factors of bioterrorism describing the general characteristics, mechanisms of action and treatment of most potent biological toxins. -
Warfare Agents for Modeling Airborne Dispersion in and Around Buildings
LBNL-45475 ERNEST ORLANDO LAWRENCE BERKELEY NATIn NAL LABORATORY Databaseof Physical,Chemicaland ToxicologicalPropertiesof Chemical and Biological(CB)WarfitreAgentsfor ModelingAirborneDispersionIn and AroundBuildings TracyThatcher,RichSextro,andDonErmak Environmental Energy Technologies Division DISCLAIMER This document was prepared as an account of work sponsored by the United States Government. While this document is believed to contain correct information, neither the United States Government nor any agency thereof, nor The Regents of the University of Catifomia, nor any of their employees, makes any warranty, express or implied, or assumes any legal responsibility for the accuracy, completeness, or usefulness of anY information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by its trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommend at i on, or favoring by the United States Government or any agency thereof, or The Regents of the University of California. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof, or The Regents of the University of California. Ernest Orlando Lawrence Berkeley National Laboratory is an equal opportunity employer. DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced -
The Science of the Bioeconomy
The science of the Bioeconomy Dr. Henrike Gebhardt 05 December 2014 Our positioning Evonik is the creative industrial group from Germany and one of the world’s leading specialty chemicals companies. The Science of the Bioeconomy Page 3 Our credo The Bioeconomy is one driver to promote a more resource-efficient and sustainable economy. Industrial biotechnology is a key technology for realising the bioeconomy. The Science of the Bioeconomy Page 5 Overview Bioeconomy Biotechnology Genetic engineering The Science of the Bioeconomy Page 6 Definitions Bioeconomy Production of renewable biological resources and the conversion of these resources and waste streams into value added products, such as food, feed, and other industrial products and energy. COM(2012) 60, EU Commission, mod. Bio-basedBiotechnology products ProductsThe use whollyof living or organisms partly derived or their from components biomass. EN to16575 make products. Genetic engineering Any of various applications of biological science used in the manipulation of the genome of an organism The Science of the Bioeconomy Page 7 Bio-based products offered by Evonik Polyamids Polyesters VESTAMID ®Terra DYNACOLL ®Terra DYNAPOL ®Terra VISIOMER ®Terra Additives Amino acids Cosmetics BioMTBE Feed additives Health – purified TEGOSOFT ®MM bio-based AdditivesCleaning Health VISCOPLEX ® Series 10 Esterquats RESOMER ® bio- degradable The Science of the Bioeconomy Page 8 Evonik invests in high-growth chemical megatrends Lighthouse investment projects Lysine Russia Consumer Specialties China C4 Chemistry H O / HPPO Europe 2 2 Lysine Expansion China USA Crosslinkers, Isophorone China Consumer Specialties Superabsorbents Brazil Saudi Arabia Methionine Singapore Biodiesel catalysts Argentina Bioeconomy Lysine Traditional Brazil The Science of the Bioeconomy Page 9 Bioeconomy Press releases Company Raw Intermediate Product Material Date of Issue Volume Commissioning DSM/POET (USA) Cellulosics Ethanol Biofuels from corn Jan 2012 90 kta H1.2014 cobs Purac/BASF (ES) Cellulosics Succinic acid e. -
International Handbook of Foodborne Pathogens
INTERNATIONAL HANDBOOK OF FOODBORNE PATHOGENS EDITED BY MARIANNE D. MILIOTIS U.S. Food and Drug Administration College Park, Maryland, U.S.A. JEFFREY W. BIER Food Safety Consultant Alexandria, Virginia, U.S.A. MARCEL H MARCEL DEKKER, INC. NEW YORK • BASEL Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress. ISBN: 0-8247-0685-4 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-260-6300; fax: 41-61-260-6333 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10987654321 PRINTED IN THE UNITED STATES OF AMERICA Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. FOOD SCIENCE AND TECHNOLOGY A Series of Monographs, Textbooks, and Reference Books EDITORIAL BOARD Senior Editors Owen R. Fennema University of Wisconsin-Madison Y. H. Hui Science Technology System Marcus Karel Rutgers University (emeritus) Pieter Walstra Wagenmgen University John R. -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles. -
Engineering Botulinum Neurotoxins for Enhanced Therapeutic Applications and Vaccine Development
toxins Review Engineering Botulinum Neurotoxins for Enhanced Therapeutic Applications and Vaccine Development Christine Rasetti-Escargueil * and Michel R. Popoff Toxines Bacteriennes, Institut Pasteur, 75724 Paris, France; [email protected] * Correspondence: [email protected] Abstract: Botulinum neurotoxins (BoNTs) show increasing therapeutic applications ranging from treatment of locally paralyzed muscles to cosmetic benefits. At first, in the 1970s, BoNT was used for the treatment of strabismus, however, nowadays, BoNT has multiple medical applications including the treatment of muscle hyperactivity such as strabismus, dystonia, movement disorders, hemifacial spasm, essential tremor, tics, cervical dystonia, cerebral palsy, as well as secretory disorders (hyperhidrosis, sialorrhea) and pain syndromes such as chronic migraine. This review summarizes current knowledge related to engineering of botulinum toxins, with particular emphasis on their potential therapeutic applications for pain management and for retargeting to non-neuronal tissues. Advances in molecular biology have resulted in generating modified BoNTs with the potential to act in a variety of disorders, however, in addition to the modifications of well characterized toxinotypes, the diversity of the wild type BoNT toxinotypes or subtypes, provides the basis for innovative BoNT- based therapeutics and research tools. This expanding BoNT superfamily forms the foundation for new toxins candidates in a wider range of therapeutic options. Keywords: botulinum neurotoxin; Clostridium botulinum; therapeutic application; recombinant toxin; toxin engineering Key Contribution: Botulinum neurotoxins (BoNTs) are the deadliest toxins with an increasing number of medical applications. The generation of modified BoNTs has provided innovative tools Citation: Rasetti-Escargueil, C.; Popoff, for specific medical applications. M.R. Engineering Botulinum Neuro- toxins for Enhanced Therapeutic Ap- plications and Vaccine Development. -
Argonne Report.Pdf
CONTENTS NOTATION ........................................................................................................................... xi ABSTRACT ........................................................................................................................... 1 1 INTRODUCTION ........................................................................................................... 5 1.1 Overview of the Emergency Response Guidebook ................................................ 5 1.2 Organization of this Report ..................................................................................... 7 2 GENERAL METHODOLOGY ....................................................................................... 9 2.1 TIH List ................................................................................................................... 10 2.1.1 Background ................................................................................................. 10 2.1.2 Changes in the TIH List for the ERG2012 ................................................. 11 2.2 Shipment and Release Scenarios ............................................................................ 11 2.2.1 Shipment Profiles ........................................................................................ 12 2.2.2 Treatment of Chemical Agents ................................................................... 14 2.3 Generics, Mixtures, and Solutions .......................................................................... 17 2.4 Analysis of Water-Reactive -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime.