CONFERENCE PROGRAM
CONFERENCE PROGRAM zdmsociety.org/zdm11 THANK YOU TO OUR SUPPORTERS! WELCOME TO ZDM11 ...... Dear ZDM11 Attendees, GOLD Welcome to Leiden! We are delighted to host the zebrafish community for the 11th Zebrafish Disease Models Conference, particularly because Leiden hosted what turned out to be the first ZDM Conference in 2007, ZDM1! Leiden has had an active zebrafish community for over two decades with strong ties to the Hubrecht Institute in Utrecht and practically all other universities in the Netherlands, most of which are less than an hour away.
...... Leiden University was founded in 1575, is the oldest university in the Netherlands and is one SILVER of Europe’s leading international research universities. In addition, Leiden University campus, where the conference takes place, is home to Leiden Bio Science Park, the largest life sciences cluster in the Netherlands. Next to the university, there are more than 100 dedicated medical life sciences companies and institutions located close together, including several multinational ...... and internationally acclaimed research institutes.
RECEPTION SPONSOR Leiden is a typical university city with university buildings scattered throughout the city. The many students from all over the world give the city a bustling, vivid and international atmosphere. The downtown area is riddled with bars and restaurants, with something for everyone’s liking...... We look forward to an inspiring and interactive conference with cutting edge science and social CONTRIBUTORS activities alike. Please, enjoy the conference in all its facets.
Warm regards,
...... The ZDM11 Local Organization Committee EXHIBITORS Herman Spaink, Jeroen den Hertog, Marcel Schaaf, Ph.D. Ph.D. Ph.D.
Ewa Snaar-Jagalska, Fons Verbeek, Sonja Wijfjes-Chang Ph.D. Ph.D.
WORLD PRECISION INSTRUMENTS Instrumenting scientific ideas
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1 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 2 TABLE OF CONTENTS WELCOME TO ZDM11 ...... July 10, 2018
Supporter Appreciation 1 I am excited to welcome all of you to Leiden for ZDM11, the 11th Zebrafish Disease Models Welcome to ZDM11 2 conference. Contents 3 As many of you know, this is not the first ZDM meeting to take place in Leiden. Indeed, the inaugural meeting, ‘Model Systems for Infectious Disease and Cancer in Zebrafish’, was held here Letter from the ZDMS President 4 in July 2007 with 42 participants and by all accounts it was fantastic. As you will see from the ZDMS Leadership 5 Program, these days the scope of ZDM conferences extends far beyond infectious disease and ZDMS RIG Leaders 6 cancer, and we will be showcasing the very best work in neurological disorders, cardiac and skeletal muscle disease, inflammatory disease and diseases of the blood, vasculature and digestive organs. Award Recipients 7 Keynote Speakers/ Social Programs 8 We are thrilled that two local luminaries, Professors Christine Mummery and Alexander van Oudenaarden, have agreed to be our Keynote speakers. I am sure their presentations will be Organ Performance by Graham Lieschke 9 amongst the highlights of the conference. Over the course of the meeting, we can also look Conference Information 10 forward to hearing from 18 terrific invited speakers who have gathered here from all around the world. Yet another high spot will be the talks from the winners of our first Junior Faculty Award for Conference Program 11 Excellence. And, in what I hope will prove to be an ingenious experiment, we will hold one of our Map of Leiden 24 plenary sessions in Pieterskerk, a local building of great cultural significance, where we will have Conference Posters 25 the opportunity to mix science with music. Exhibit Hall Floorplan 33 As we have come to expect, the local organizing committee have kept a keen eye on the social events as well as the scientific program and I would like to thank Herman Spaink, Jeroen den Exhibitors 35 Hertog, Marcel Schaaf, Ewa Snaar-Jagalska, Fons Verbeek and Sonja Wijfjes-Chang for their ZDM12 41 magnificent efforts in bringing it all together. Conference organization requires imagination, inspiration and tireless negotiation skills, and these six people demonstrated these qualities in abundance.
Jeroen den Hertog and David Langenau co-chaired a Scientific Program sub-committee which drew support from the LOC, the ZDMS Board of Directors and the Chairs of the Research Interest Groups. By the end of the week, I am sure you will agree that we did a pretty good job!
None of this would have been possible without the unerring support of our conference partner, Site Solutions Worldwide. I thank Sarah Hughes, Sara Aldrich, Marissa Streun, Nathalie Whitton, Lisa Cormier, Kristina Agresta and Chantal Smith for the skill and attention to detail they brought to all aspects of the meeting. I also wish to thank our generous sponsors from academia and industry, @ZDMSociety #ZDM11 especially those that have been with us for many years.
So, as you can see, we have done our best to bring together all the ingredients for a truly facebook.com/zdmsociety memorable meeting – the rest is up to you! Best wishes, @ZDMSociety
Joan K Heath President, Zebrafish Disease Models Society
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3 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 4 ZDMS LEADERSHIP RESEARCH INTEREST GROUP LEADERS ...... EXECUTIVE COMMITTEE CANCER President Craig Ceol, University of Massachusetts Medical School, Massachusetts, USA Joan Heath, Ph.D Richard White, Memorial Sloan Kettering Cancer Center, New York, USA The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia DRUG DISCOVERY Hui Feng, Boston University School of Medicine, Massachusetts, USA Vice President Elizabeth Patton, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom Graham Lieschke, M.B., B.S., B.Med.Sc., Ph.D, F.R.A.C.P. Australian Regenerative Medicine Institute and Royal Melbourne Hospital, Victoria, Australia EDUCATION Michael Pickart, Concordia University Wisconsin, Wisconsin, USA Christopher Pierret, Mayo Clinic, Minnesota, USA Vice President in Waiting David Langenau, Ph.D Massachusetts General Hospital, Massachusetts, USA GI METABOLISM Steve Farber, Carnegie Institution for Science, Maryland, USA Michael Pack, University of Pennsylvania, Pennsylvania, USA Treasurer Elizabeth Patton, Ph.D MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK HEMATOLOGY Jason Berman, IWK Health Centre, Dalhousie University, Nova Scotia, Canada Trista North, Boston Children’s Hospital, Harvard Medical School, Massachusetts, USA
Clerk Leonard Zon, MD INFECTION AND INFLAMMATION Boston Children’s Hospital, Massachusetts, USA Anna Huttenlocher,University of Wisconsin, Wisconsin, USA Herman Spaink, Leiden University, Leiden, The Netherlands BOARD OF DIRECTORS James Amatruda, UT Southwestern Medical Center, Texas, USA MUSCLE AND CARDIAC DISEASE Jason Berman, IWK Health Centre, Nova Scotia, Canada Peter Currie, Australian Regenerative Medicine Institute, Monash University, Victoria, Australia Shawn Burgess, National Human Genome Research Institute, Maryland, USA Stephen C. Ekker (Past President), Biochemistry & Molecular Biology, Mayo Clinic, Minnesota, USA Jill de Jong, University of Chicago, Illinois, USA NEURAL Clarissa Henry, University of Maine, Maine, USA Sadie Bergeron, Whitehead Institute for Biomedical Research, Massachusetts, USA Anna Huttenlocher, University of Wisconsin, Wisconsin, USA Ellen Hoffman,Yale University, Connecticut, USA Koichi Kawakami, National Institute of Genetics, Japan Paul Martin, University of Bristol, Bristol, UK Leiden University, Leiden, Netherlands Annemarie Meijer, SKELETAL Marina Mione, University of Trento, Trento, Italy Christian Mosimann, University of Zurich, Zurich, Switzerland Jacek Topczewski, Northwestern University Feinberg School of Medicine, Illinois, USA Victor Mulero, University of Murcia, Murcia, Spain Shannon Fisher, Boston University School of Medicine, Massachusetts, USA John Rawls, Duke University, North Carolina, USA Stephen Renshaw, University of Sheffield, South Yorkshire, UK Kirsten Sadler Edepli, New York University Abu Dhabi, United Arab Emirates TOXICOLOGY Han Wang, Soochow University, Suzhou, China Joshua Gamse, Bristol-Myers Squibb, New Jersey, USA Richard White, Memorial Sloan Kettering Cancer Center, New York, USA Daniel Gorelick, University of Alabama at Birmingham, Alabama, USA ......
5 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 6 AWARD RECIPIENTS KEYNOTE SPEAKERS ...... Recipients of the ZDMS Junior Faculty Award for Excellence ZDMS is pleased to announce the first ever recipients of the ZDMS Junior Faculty Award for Excellence. This award Alexander van Oudenaarden obtained his PhD in physics in recognizes excellence in zebrafish disease modeling research by an early career independent investigator 1998 from Delft University, the Netherlands. After a postdoc at Stanford, he moved to MIT in Cambridge, MA in 2000 and became Kazu Kikuchi Trista North Professor of Physics in 2008, as well as Professor of Biology in 2009. In 2012, he moved back to the Netherlands to become Victor Chang Cardiac Research Boston Children’s Hospital, director of the Hubrecht Institute for developmental biology and Institute Harvard Medical School stem cell research and Professor of Quantitative Biology at Utrecht Sydney, Australia Massachusetts, USA University. In his research, he combines biology with physics and informatics to gain insight into the quantitative biology of development and ZDM11 Conference Award Recipients stem cells. He is one of the pioneers of single cell RNA-sequencing Congratulations to the ZDMS11 Conference Award recipients. and his lab has developed several bio-informatics tools to analyze these data in detail. For his work, he has received many grants and Alexander van Oudenaarden, Ph.D. prizes, including the ERC advanced grant (twice) and in 2017 the Viviana Anelli Ellen Hoffman Mirana Ramialison Hubrecht Institute-KNAW, University Medical biggest science prize in the Netherlands, the Spinoza prize. University of Trento Yale University Australian Regenerative Medicine Trento, Italy Connecticut, USA Institute Center Utrecht & Utrecht University Victoria, Australia Sasja Blokzijl-Franke Sowjanya Kallakuri Christine Mummery is Chair of Anatomy and Embryology and Hubrecht Institute Lee Kong Chian School of Christoph Schuerch Professor of Developmental Biology at Leiden University Medical Utrecht, The Netherlands Medicine University Hospital Basel Center. Her research concerns cardiovascular development Singapore Scotland, UK and disease models based on human pluripotent stem cells. Nadja Brun Immediate interests are on developing biophysical techniques Woods Hole Oceanographic Betelhem Kassa Angie Serrano for characterization and functional analysis of cardiovascular cells Institution INRS-IAF University of Utah – EIHG from hPSC. In 2015, she became guest professor at the Technical Massachusetts, USA Quebec, Canada Utah, USA University of Twente to develop organ-on-chip models. Hannah Brunsdon Aya Ludin Tal Yuki Shimizu Dr. Mummery is a member of the Royal Netherlands Academy Institute of Genetics and Harvard University Waseda University of Science, on the board of the Netherlands Medical Research Molecular Medicine Massachusetts, USA Tokyo, Japan Council and holds a European Research Council Advanced Grant University of Edinburgh to study cardiac development and disease in humans based on Midlothian, UK Harriet Manley Matthew Stoyek stem cell models. She wrote a lay-guide on stem cells “Stem Cell: Australian Regenerative Medicine Dalhousie University Scientific Facts and Fiction” (Elsevier 2014) and is Editor-in-Chief of Siobhan Crilly Institute, Monash University Nova Scotia, Canada Stem Cell Reports, the journal of the International Society of Stem The University of Manchester Australia Christine Mummery, Ph.D. Cell Research. She is also on the editorial boards of Cell Stem Cell, Manchester, United Kingdom Victoria, Australia Kelsey Temprine Leiden University Medical Center Cardiovascular Research and Stem Cells. Memorial Sloan Kettering Cancer Center Karen Doggett Rui Monteiro New York, USA Walter and Eliza Hall Institute University of Birmingham of Medical Research West Midlands, UK Rob Christiaan Van Wijk SOCIAL PROGRAMS Victoria, Australia Leiden University Nikolay Orgryzko Zuid-Holland, The Netherlands Shuning He University of Edinburgh, UK Tuesday, July 10th 3:30pm Dana-Farber Cancer Institute Zoltan Kristof Varga Massachusetts, USA 6:00pm – 8:00pm Buses meet to bring those who attended the Mentoring Institute of Experimental Medicine Welcome Reception Sessions to Pieterskerk for Plenary Session 5 and a musical Pest, Hungary Sponsored by Thermo Fisher Scientific performance by Graham Lieschke, (Transportation back to Courtyard Gardens at Leiden University the hotels and meeting venue will not be provided) ZDMS would like to send out a special thank you to the following ZDMS Awards Committee 7:00pm Wednesday, July 11th Post Doc and Graduate Student Night Out members for their dedication and hard work in reviewing the many qualified applications. 2:00pm Location to be Announced Buses meet to bring those not attending the Mentoring Junior Faculty Award for Excellence Committee Members: Conference Award Committee Members: Sessions to Pieterskerk for a walking tour around the Thursday, July 12th Committee Chairs: Committee Chairs: area followed by Plenary Session 5 and a musical 7:00pm – 11:00pm David Langenau David Langenau performance by Graham Lieschke (Transportation back ZDM11 Conference Dinner to the hotels and meeting venue will not be provided) Hortus Botanicus Leiden Marina Mione Marina Mione Rapenburg 73, 2311 GJ Leiden, Netherlands Committee Members: Committee Members: Transportation will be provided from Leiden University to Jason Berman Koichi Kawakami Tom Carney the Hortus Botanicus and back to Leiden University. Tom Carney Stephen Renshaw Shuning He Stephen Ekker Kirsten Sadler Edepli Clarissa Henry Anna Huttenlocher Ewa Snaar David Langenau ......
7 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 8 CONFERENCE INFORMATION ...... Join us at Pieterskerk on Wednesday, July 11th for Plenary Session 5 and an organ performance by the ZDMS Vice President, Graham Lieschke. ZDM11 will take place at the Leiden University Faculty Science Building, located at Einsteinweg 55, 2333 CC Leiden, The Netherlands. The historic van Hagerbeer organ of the Pieterskerk was built in 1643, incorporating pipework from an older instrument dating back to at least 1518. Very likely, some of its pipes made REGISTRATION INFORMATION CONTACT INFORMATION sounds heard by the Pilgrim Fathers! A recent restoration returned it to its original 17th centu- The registration desk is located on the ground floor of For questions or concerns throughout ry state. Its many special features include the opulent case featuring 24-foot long pipes, which the Leiden University Faculty Science Building and is the conference, please contact one of the are played from the middle of its 3 keyboards. Despite challenges that very old instruments open during the following times: following people. present both for the modern player (non-standard dimensions) and for modern listeners (an Tuesday, July 10th Sarah Hughes, CMP unequal tuning system called meantone), we are definitely going to have some fun….. 11:00am – 6:00pm Sr. Meeting Consultant Wednesday, July 11th Site Solutions Worldwide John Stanley (English, 1712-1786) 7:00am – 4:00pm [email protected] Voluntary in F major 5 min Thursday, July 12th Mobile - +011 518 527 0762 A short prelude uses the façade pipes you can see, and then a fanfare for “Corno” [horn] alter- 7:00am – 5:00pm nates with a quiet flute. Friday, July 13th 7:00am – 12:00pm Emily Cooper Georg Böhm (German, 1661-1733) WIFI Access: Registration Specialist Christ lag in Todesbanden 5 min Complimentary wifi is available at the conference Site Solutions Worldwide A grand setting of an Easter hymn, setting sections in contrasting ways and ending with a meeting space. Please see below instructions to [email protected] gigue for the “Allelulias”. connect to the internet. Mobile - +011 518 573 5373 Connect to UL-Guest. No password is required. Jan Pieterszoon Sweelinck (Dutch, 1562-1621) Eduroam is also available. In order to connect, you Echo Fantasia 3.5 min must have arranged your authentication with your own Marissa Streun Mein junges Leben hat ein End 7 min employer. Sweelinck was a famous late renaissance/early baroque Dutch organist/composer who influ- Program Associate Site Solutions Worldwide Abstracts: enced northern European music for centuries – this organ is perfect for his music. He may well [email protected] Located within your conference bag is a printed have travelled from Amsterdam and played this organ’s predecessor in this building. Mobile - +011 518-527-3279 The Echo Fantasia exploits the spatial separation of different parts of the organ. booklet of the ZDM11 Abstracts. Sweelinck was famous for his improvised settings of hymn and songs – before recorded music and iPhones, organ concerts were popular public entertainment. “My young life has an end” is a secular song contemplating the end of life – this set of 6 variations on the tune is Sweelinck’s most famous piece. Meals Dieterich Buxtehude (Danish - North German, 1637-1707) Meals will be provided for all conference attendees as follows: Praeludium G minor (BuxWV149) 8 min Tuesday, July 10th Buxtehude’s large organ in the Marienkirche Lübeck was contem- Refreshment Break with Coffee, Tea and Snacks poraneous with the Pieterskerk organ – it also dated from 1518, Welcome Reception with Light Snacks and Alcoholic and Non-Alcoholic Beverages and was rebuilt 1641. This prelude with its multiple sections and connecting chordal interludes is very typical of late 1600s virtuosic Wednesday, July 11th organ music. It starts with a chaconne (there is a repeating figure Morning Refreshment Break with Coffee, Tea and Snacks Buffet Lunch in the bass, played with the feet). The concluding 4th section is a majestic, harmonically adventurous fugue on full organ. Thursday, July 12th Morning and Afternoon Refreshment Breaks with Coffee, Tea and Snacks Buffet Lunch When not modelling blood diseases in zebrafish, Graham Lieschke is often found in organ lofts. He is Director of Music at St Johns Friday, July 13th Lutheran Church, Southgate, in Melbourne Australia. Morning Refreshment Break with Coffee, Tea and Snacks Buffet Lunch ......
9 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 10 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... th Plenary Session 2: Cancer I - 3:30pm - 5:10pm Tuesday, July 10 , 2018 Session Chair: Hui Feng Location: Zaal 4/5 Paper Time Session / Speaker No. Abstract Title Loss of GAS7 expression promotes 11:00am - 6:00pm Registration Open - Ground Floor 3:40pm - 3:55pm Jane Zhu, Mayo Clinic , USA O-07 metastasis in neuroblastoma with MYCN overexpression 1:00pm - 3:00pm Welcome Session - Location: Zaal 4/5 Zebrafish avatars of human cancer: Welcome Remarks by: David Langenau, Massachusetts 1:00pm - 1:10pm 3:55pm - 4:10pm O-08 Growing zenografts in adult immune Joan Heath, President, Zebrafish Disease Models Society, and Herman Spaink, General Hospital, USA Local Organizing Committee compromised zebrafish
Plenary Session 1/ Opening Session - 1:10pm - 3:10pm Anti-viral pathways and epigenetic Session Chair: Jeroen den Hertog Kirsten Sadler Edepli, New York compensation as a protection against Location: Zaal 4/5 4:10pm - 4:25pm University Abu Dhabi, United O-09 transposon activation in zebrafish Arab Emirates 1:10pm - 1:30pm Leonard Zon, HHMI/Children's Stem cell niche formation using the and mice Hospital, USA O-01 zebrafish
Stephen Renshaw, University Modulation of neutrophil reverse Wolfram Goessling, Brigham Mutations in RABL3 alter KRAS 1:30pm - 1:50pm of Sheffield Medical School, O-02 migration as a pro-resolution strategy in 4:25pm - 4:40pm and Women's Hospital/Harvard O-10 prenylation and are associated with UK inflammatory disease Medical School, USA hereditary pancreatic cancer
Ariane Briegel, Leiden Cholera infection of zebrafish larvae at 1:50pm - 2:10pm O-03 Live imaging both active and University, The Netherlands the nanoscale opportunistic breaching of the Maaike van den Berg, University 4:40pm - 4:55pm O-11 basement membrane by immune of Bristol, UK Stefan Schulte-Merker, Notochord sheath cells are essential for cells as they access early stage skin 2:10pm - 2:30pm University of Münster, O-04 development and regeneration of the cancers Germany spine Rita Fior, University of Lisbon, Human zebrafish xenografts as 4:55pm - 5:10pm O-12 Kazu Kikuchi, Victor Chang Portugal therapy sensors for breast cancer Cardiac Research Institute, Zebrafish regulatory T cells mediate 2:30pm - 2:50pm Australia O-05 ZDMS Junior Faculty Award organ-specific regenerative programs Keynote Presentation - 5:10pm - 6:10pm for Excellence Recipient Introductions by: Alexander van Oudenaarden Location: Zaal 4/5 Trista North, Boston Children's Hospital, USA Alexander van Oudenaarden,Ph.D 2:50pm - 3:10pm O-06 Extrinsic regulation of hematopoiesis Hubrecht Institute-KNAW, Keynote Presentation: Whole- ZDMS Junior Faculty Award O-13 organism clone-tracing using single- for Excellence Recipient 5:10pm - 6:10pm University Medical Center Utrecht & Utrecht University, Utrecht, cell sequencing 3:10pm - 3:40pm Afternoon Break - Exhibit Area (Sponsored by Boston Children's Hospital) The Netherlands 6:10pm - 8:00pm Welcome Reception - Courtyard Garden
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11 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 12 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... th Wednesday, July 11 , 2018 10:00am - 10:30am Morning Break - Exhibit Area
Time Session / Speaker Abstract Title Concurrent Session 4A: Cancer - 10:30am - 12:00pm Session Chair: Jane Zhu Location: Zaal 4/5 7:00am - 4:00pm Registration Open - Ground Floor Kelsey Temprine, Memorial Error-prone DNA polymerases as a Plenary Session 3: Muscle, Skeletal, and Cardiac Disease - 8:30am - 10:00am Session Chair: Kirsten Sadler Edepli 10:30am - 10:45am Sloan Kettering Cancer Center, O-19 mechanism for tumor evolution and Location: Zaal 4/5 USA drug resistance
Jeroen Bakkers, Hubrecht Mechanical transduction mediated Genetic zebrafish models to study cardiac 8:30am - 8:45am Institute, Utrecht, The O-14 by Integrin-ILK dependent actin diseases Lanpeng Chen, Leiden 10:45am - 11:00am O-20 dynamics drives stem-plasticity Netherlands University, The Netherlands leading to experimental metastatic Marcel den Hoed, Uppsala Zebrafish larvae as a model system for colonization of prostate cancer 8:45am - 9:00am O-15 University, Sweden large-scale, image-based genetic screens in dyslipidemia and atherosclerosis Kimble Frazer, University of Defining ‘New’ MYC-Driven Pre-B ALL 11:00am - 11:15am Oklahoma Health Sciences O-21 in an ‘Old’ zebrafish model Angie Serrano, University of Notch inhibition rescues cardiovascular Center, USA 9:00am - 9:15am O-16 phenotype in zebrafish with kabuki Utah - EIHG, USA syndrome Zebrafish modeling of the novel Genevieve Kendall, UT VGLL2-NCOA2 fusion oncogene Chrissy Hammond, Rapid functional analysis of osteoarthritis 9:15am - 9:30am O-17 11:15am - 11:30am Southwestern Medical Center, O-22 generates rhabdomyosarcoma that University of Bristol, UK susceptibility genes using zebrafish as a toolkit USA reflects aberrant embryonic muscle development Yaniv Hinits, Kings College Scxa is essential for rib formation and normal 9:30am - 9:45am O-18 London, UK musculoskeletal system in zebrafish Metabolic alterations play a pivotal Lisa Kelly, The University of 11:30am - 11:45am O-23 role in the pre-neoplastic cell niche Flash Talks by: Edinburgh, UK during tumour initiation • Aurore Anton, Universite Paul Sabatier, France - Modelling Diamond-Blackfan Anemia in the zebrafish Melanomas with NF1 and PTEN Shuning He, Dana-Farber mutations depend on mTOR signaling 11:45am - 12:00pm O-24 • Petra Bakker, Hubrecht Institute, The Netherlands - Shp1 phosphatase signaling in Cancer Institute, USA and the combined actions of BCL2 vivo in a zebrafish model and MCL1 for cell growth and survival
• Prabesh Bhattarai, DZNE, Germany - Amyloid beta42-induced Interleukin-4 regulates neural stem cell plasticity after neurodegeneration in adult zebrafish brain
• Hannah Brunsdon, University of Edinburgh, UK - ALDH2 regulates the melanocyte 9:45am - 10:00am stem cell lineage
• Alexa Burger, University of Zurich, Switzerland - RBM8A deficiency in TAR syndrome impacts the lateral plate mesoderm
• Scott Callahan, Memorial Sloan Kettering Cancer Center, USA - Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
• Jesus Garcia-Castillo, Instituto Murciano de Investigacion Biosanitaria, Spain, Telomerase lncRNA recruits RNA polymerase II to target genes to promote myelopoiesis
Monitored by: Marcel Schaaf
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13 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 14 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... th Concurrent Mentoring Session - Grad Students - Canteen Wednesday, July 11 , 2018 Facilitated by Elizabeth Patton and Kirsten Sadler Edepli Graduate students have a lot of resources - and a lot of pressure - to make it through Paper Time Session / Speaker Abstract Title 2:00pm - 3:00pm to obtaining that prized degree. At this session, participants will have an opportunity No. to speak in small groups with current post-docs, junior and established investigators about how to traverse their graduate education and plan for the next steps in their Concurrent Session 4B: Infectious Disease and Immune Cells - 10:30am - 12:00pm career. Session Chair: Victoriano Mulero Location: Zaal 3 Concurrent Mentoring Session - Post Docs - Canteen Facilitated by Elizabeth Patton and Kirsten Sadler Edepli Nikolay Ninov, Center for Modelling beta-cell inflammation in 2:00pm - 3:00pm The post-doctoral training period provides a forum for launching a career. Come to 10:30am - 10:45am Regenerative Therapies O-25 zebrafish identifies a natural product this session to speak in small groups with senior scientists, junior and established Dresden, Germany for human beta-cell protection investigators about how to navigate the post-doctoral period to plan for the next steps in your career. The chemokine receptors Cxcr3.2 Frida Sommer, Leiden and Cxcr3.3 function antagonistically 3:00pm Transportation to Pieterskerk for Plenary Session 5 (for those who attended the 10:45am - 11:00am O-26 Mentoring Sessions) University, The Netherlands in the immune response against mycobacterial infection Plenary Session 5: Pieterskerk Session - 4:00pm - 5:00pm Session Chair: Joan Heath Pedro Moura-Alves, MPIIB, AhR monitors bacterial quorum 11:00am - 11:15am O-27 Germany sensing and infection dynamics Didier Stainier, Max Planck Genetic compensation and 4:00pm - 4:20pm Institute for Heart and Lung O-31 transcriptional adaptation Hif-1alpha upregulates macrophage Research, Germany Philip Elks, University of Il-1beta to drive protective nitric 11:15am - 11:30am O-28 Sheffield, UK oxide production in a zebrafish mycobacterial model Synthetic lethal targeting of Clonal Thomas Look, Dana-Farber Hematopoiesis with Indeterminate 4:20pm - 4:40pm O-32 A zebrafish reporter line reveals Cancer Institute, USA Potential (CHIP) using zebrafish Noemie Hamilton, University endogenous retrovirus activation in models 11:30am - 11:45am O-29 of Sheffield, UK innate immune cells as a therapeutic target for neurological disorders Anna Huttenlocher, University Imaging inflammation induced by of Wisconsin School of 4:40pm - 5:00pm O-33 high fat diet and hepatocellular Jordan Shavit, University of Surprisingly rapid onset of estrogen- Medicine and Public Health, 11:45am - 12:00pm O-30 carcinoma Michigan Medical School, USA induced venous thrombosis USA
Keynote Presentation - 5:00pm - 6:00pm 12:00pm - 2:00pm Lunch and Poster Session 1 - Canteen (Sponsored by Friends of Hubrecht Institute) Introductions by: Herman Spaink
2:00pm Transportation to Pieterskerk for Walking Tour and Plenary Session 5 (for those not attending the Mentoring Sessions) Christine Mummery, Ph.D. Keynote Presentation: Cardiovascular 5:00pm - 6:00pm Leiden University Medical O-34 diseases and drugs: where are we Center, The Netherlands with hiPSC models?
6:00pm - 6:30pm Organ Recital: Graham Lieschke, Monash University, Australia
7:00pm - Late Grad Student/ Post Doc Night Out
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15 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 16 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... th Concurrent Session 7A: Blood and Hematopoiesis - 10:30am - 12:00pm Thursday, July 12 , 2018 Session Chair: Graham Lieschke Location: Zaal 4/5 Paper Time Session / Speaker No. Abstract Title Aya Ludin, Harvard University, Activated CD8+ T cells and CD8+ dendritic 10:30am - 10:45am O-40 7:00am - 5:00pm Registration Open - Ground Floor USA cells invade melanoma tumors in zebrafish
Plenary Session 6: Microbe-Host Interactions - 8:30am - 10:00am Modulation of gata2 levels through Rui Monteiro, University of an endothelial enhancer regulate Session Chair: Annemarie Meijer 10:45am - 11:00am O-41 Location: Zaal 4/5 Birmingham, UK haematopoietic activity in embryonic and adult haematopoietic stem cells Bjoern Koch, Leiden The microbiome suppresses aberrant innate 8:30am - 8:45am O-35 University, The Netherlands immune responses through TLR2 and Myd88 Yoonsung Lee, IBS/Center The histone chaperone Supt16h modulates signaling 11:00am - 11:15am for Genomic Integrity, Korea, O-42 Notch signaling through p53 to specify Republic of (South Korea) hematopoietic stem cells TNF orchestrates a pathogenic Francisco Jose Roca Soler, mitochondrial-lysosomal-endoplasmic 8:45am - 9:00am O-36 reticulum circuit which culminates in Stylianos Lefkopoulos, University of Cambridge, UK Max Planck Institute Role of RIG-I-like receptors in programmed macrophage necrosis in 11:15am - 11:30am O-43 tuberculosis of Immunobiology & developmental hematopoiesis Epigenetics, Germany Beatriz Novoa, Institute A zebrafish model for the study of of Marine Research, IIM, gastroenteric Aeromonas reveals the Harriet Manley, Australian 9:00am - 9:15am O-37 National Research Council, importance of polar flagellum glycosylation Regenerative Medicine Influence of nuclear structure on migratory in gram-negative virulence and immune 11:30am - 11:45am O-44 Spain stimulation Institute, Monash University, cell function - the neutrophil paradigm. Australia Vincenzo Torraca, Imperial Use of zebrafish to study the host response 9:15am - 9:30am O-38 Live imaging of wound angiogenesis reveals College London, UK to shigella infection in vivo David Gurevich, University of 11:45am - 12:00pm O-45 macrophages orchestrate vessel sprouting Bristol, UK and regression In vivo analysis of intestinal epithelial 9:30am - 9:45am John Rawls, Duke University School of Medicine, USA O-39 damage responses in a zebrafish model of Concurrent Session 7B: Disease and Development - 10:30am - 12:00pm NSAID-induced enteropathy Session Chair: Paul Martin Location: Zaal 3 Flash Talks by: James Minchin, University of Deep phenotyping reveals genetic and diet- 10:30am - 10:45am O-46 • Siobhan Crilly, The University of Manchester, UK - Using zebrafish larvae to model Edinburgh, UK induced adiposity changes in zebrafish haemorrhagic stroke
Maja Solman, Hubrecht Development of Noonan syndrome • Mohankrishna Dalvoy, Ulm University, Germany - Tight regulation of autophagy is 10:45am - 11:00am O-47 essential for zebrafish heart regeneration Institute, The Netherlands zebrafish
• Jill de Jong, University of Chicago, USA - The side population assay enriches for Kick-starting drug development; the leukemia stem cells in zebrafish T-ALL Rob van Wijk, LACDR, Leiden bridging role of innovative zebrafish 11:00am - 11:15am O-48 University, The Netherlands experiments and advanced computational 9:45am - 10:00am • Collette LaVigne, University of Texas Southwestern Medical Center, USA - A zebrafish sarcoma shelf screen elucidates PAX3-FOXO1 cell lineage tolerance and transformation modelling capacity Christian Mosimann, Bcl9 and Pygo mutations cause congenital • Francisco Juan Martinez-Navarro, Universidad de Murcia, Spain - Vitamin B6 plays a Institute of Molecular Life 11:15am - 11:30am O-49 heart defects by tissue-specific perturbation crucial role in psoriasis Sciences, University of Zurich, of Wnt/beta-catenin signaling Switzerland • Alicia McConnell, Boston Children’s Hospital, USA - Neural crest transcription factors induce reactivation of neural crest progenitor cell fate in adult zebrafish Yasuhito Shimada, Mie Microbiome alteration in type 2 diabetes 11:30am - 11:45am University Graduate School of O-50 Monitored by: Marcel Schaaf mellitus model of zebrafish Medicine, Japan
10:00am - 10:30am Morning Break - Exhibit Area (Sponsored by Tecniplast) Karen Doggett, Walter and Minor class splicing inhibition produces 11:45am - 12:00pm Eliza Hall Institute of Medical O-51 a therapeutic benefit in hepatocellular Research, Australia carcinoma (HCC) ......
17 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 18 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... Thursday, July 12th, 2018 Welcome and Introductions Short Talks: Time Session / Speaker Paper Abstract Title - Anna Pistocchi No. - Christoph Schuerch 4:00pm - 5:00pm - Jordan Shavit 12:00pm - 2:00pm Lunch and Poster Session 2 - Canteen Hematology RIG Workshop - Zaal 3 - Ana Belen Perez-Oliva - Eirini Trompouki Plenary Session 8: Neuro and Behavior - 2:00pm - 3:30pm - Teresa Bowman Session Chair: Sadie Bergeron - Wilson Clements Location: Zaal 4/5 Closing/Future Directions Corinne Houart, King's Loss of function of axonal splicing factors 2:00pm - 2:15pm College London - Guy's O-52 Campus, UK causes neurodegeneration disorders 4:00pm - 5:00pm Welcome and Introductions Infection and Inflammation RIG Workshop Shawn Burgess, National The roles of smn1 and gemin5 in Short Presentations - selected from posters 2:15pm - 2:30pm Human Genome Research O-53 neural degeneration, regeneration and - Zaal 1 Institute, USA myelination General Discussion/Closing
Michael Lardelli, University Accelerated brain aging towards a 2:30pm - 2:45pm O-54 transcriptional inversion in a zebrafish Women’s Careers in Science: How to ask for what you want and need to be a of Adelaide, Australia model of familial Alzheimer's disease successful scientist - Zaal 4/5 Facilitated by Elizabeth Patton and Kirsten Sadler Edepli Ellen Hoffman, Yale Identifying convergent pathways in Sponsored by L’Oreal 2:45pm - 3:00pm O-55 Asking for what you need to build a successful career in science can be challenging University, USA zebrafish mutants of autism risk genes 5:00pm -6:00pm and rewarding. Gender based expectations often confound the process of making requests for women in science. Women at a range of career stages will share their Tjakko van Ham, Erasmus CSF1R haploinsufficiency leads to microglia 3:00pm - 3:15pm O-56 loss in the zebrafish and in pathogenesis of experience with making requests in professional settings, will discuss some of the MC, The Netherlands a human white matter disorder specific aspects of how to manage gendered-expectations in a career in science and will provide participants with some practical skills for making professional requests. Zoltan Kristof Varga, Early life social isolation induced 3:15pm - 3:30pm Institute of Experimental O-57 serotonergic deficits and their behavioural 6:00pm Transportation to Conference Dinner - Hortus Botanicus Leiden Medicine, Hungary consequences in zebrafish (Danio rerio) 7:00pm - 10:30pm Conference Dinner - Hortus Botanicus Leiden 3:30pm - 4:00pm Afternoon Break - Exhibit Area
Welcome and Introductions Short talks: - Jill de Jong - Kimberly Morgan 4:00pm - 5:00pm - Scott Callahan Cancer RIG Workshop - Zaal 4/5 - Nandini Asokan - Arwin Groenewoud - Dirk Sieger - Marina Mione - Alicia McConnell Community Session
Welcome and Introductions
4:00pm - 5:00pm Short Talks: Neurological Behavioral Disorders RIG - Robert Creton Workshop - Zaal 2 - Siobhan Crilly - Sadie Bergeron - Michael Lardelli Feedback/Community Session
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19 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 20 CONFERENCE PROGRAM *All names in italics denotes invited speakers CONFERENCE PROGRAM ...... th Plenary Session 10: Cancer II – 10:30am – 12:00pm Friday, July 13 , 2018 Session Chair: Ewa Snaar-Jagalska Paper Time Session / Speaker No. Abstract Title Hui Feng, Boston University UFD1: a novel contributor to MYC- 10:30am - 10:45am O-64 School of Medicine , USA mediated leukemia aggressiveness 7:00am - 12:00pm Registration Open - Ground Floor Miguel Godinho Ferreira, Plenary Session 9: Development and Disease - 8:30am - 10:00am RCAN - Institute for Research Telomere shortening in surrounding Session Chair: Christian Mosimann 10:45am - 11:00am O-65 Location: Zaal 4/5 on Cancer and Aging of Nice, tissues increases cancer incidence France Feng Liu, Institute of Zoology, Epigenetic control of hematopoietic 8:30am - 8:45am Chinese Academy of Sciences, O-58 Richard White, Memorial China stem cell development New models of metastasis in the 11:00am - 11:15am Sloan Kettering Cancer Center, O-66 zebrafish USA Zebrafish hai1 mutant embryos as an Matthias Hammerschmidt, in vivo model to elucidate the dual 8:45am - 9:00am Marina Mione, University of ALT and DNA damage in a zebrafish University of Cologne, O-59 face of the type II transmembrane 11:15am - 11:30am O-67 Germany serine protease Matriptase during Trento, Italy model of brain tumor carcinogenesis
Dirk Sieger, University of Tumor initiating cells induce Cxcr4 Deregulated metabolism in 11:30am - 11:45am O-68 mediated infiltration of pro-tumoral Anna-Pavlina Haramis, Leiden lkb1 mutant zebrafish uncovers Edinburgh, UK 9:00am - 9:15am O-60 macrophages into the brain. University, The Netherlands susceptibility to metabolic activators for targeted cancer therapy Flash Talks by:
The metastasis PRL3 phosphatase • Antonio Pagan, University of Cambridge, UK - mTOR promotes resistance to Elizabeth Patton, MRC Human controls DDX21-dependent mycobacterial infection by supporting macrophage homeostasis and infection- 9:15am - 9:30am Genetics Unit, University of O-61 transcriptional elongation to impede associated glucose metabolism Edinburgh, UK melanocyte stem cell lineage • Margherita Peron, University of Padua, Italy - Mito-Stat3 regulates cell proliferation commitment by promoting mitochondrial gene expression • Anna Pistocchi, University degli Studi di Milano, Italy - NIPBL, a new player with Teresa Bowman, Albert The spliceosomal component Sf3b1 NPMc+ in the onset of Acute Myeloid Leukemia 9:30am - 9:45am Einstein College of Medicine, O-62 prevents R-loop-mediated DNA USA damage in embryonic neurons • Mirana Ramialison, Australian Regenerative Medicine Institute, Australia - Role of 11:45am - 12:00pm Elk1 in congenital and late onset cardiac disease: at the heart of the matter Bruno Reversade, Institute Carboxypeptidase D licenses VEGFC • Christoph Schuerch, University Hospital Basel, Switzerland - A novel zebrafish 9:45am - 10:00am of Medical Biology, A*STAR, O-63 for lymphatic development model of congenital neutropenia and Shwachman-Diamond-like phenotype Singapore • Han Wang, Soochow University, China - Ezh2 positively regulates the circadian clock 10:00am - 10:30am Morning Break - Exhibit Area and hematopoiesis independent of histone methyltransferase activity in zebrafish • Marian Weterman, LUMC, The Netherlands - Loss of amino-acylation capacity is not the sole determinant for development of Charcot-Marie-Tooth disease type 2N identification of three novel pathogenic missense mutations in the gene for alanyl- tRNA synthetase
Monitored by: Marcel Schaaf
12:00pm - 2:00pm Lunch and Poster Session 3 - Canteen
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21 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 22 CONFERENCE PROGRAM *All names in italics denotes invited speakers LEIDEN MAP ...... Friday, July 13th, 2018
Paper Time Session / Speaker No. Abstract Title
Plenary Session 11: Immunity and Inflammation - 2:00pm - 3:30pm Session Chair: Stephen Renshaw Location: Zaal 4/5
Maria Leptin, EMBL, Probing inflammasome formation and 2:00pm - 2:15pm Heidelberg, University of O-69 function through optogenetics in vivo Cologne, Germany
Targeting the immune-metabolic Chris Hall, University of 2:15pm - 2:30pm O-70 interface to treat crystal-driven Auckland, New Zealand inflammation
Neutrophil-specific knockout Qin Deng, Purdue University, demonstrates a role for mitochondria 2:30pm - 2:45pm O-71 USA in regulating neutrophil motility in zebrafish
An evolutionary perspective of novel Jeff Yoder, North Carolina 2:45pm -3:00pm O-72 immunoglobulin-like transcripts State University, USA (NILTS)
Francisco Javier Martinez Pharmacological inhibition of Nampt 3:00pm -3:15pm Morcillo, Universidad de O-73 ameliorates skin inflammation in a Murcia, Spain preclinical zebrafish model
Marcel Schaaf, Leiden Glucocorticoid modulation of the 3:15pm - 3:30pm O-74 University, The Netherlands inflammatory response
3:30pm - 4:00pm Community Meeting - Zaal 4/5
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23 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 24 CONFERENCE PROGRAM CONFERENCE PROGRAM ...... Poster Session 1 Poster Session 1 Wednesday, July 11th, 2018 Wednesday, July 11th, 2018 First Floor Foyer First Floor Foyer 12:00PM - 2:00PM 12:00PM - 2:00PM Poster Poster No. Title Presenter No. Title Presenter Development of novel neurotherapies using the zebrafish model of P-025 Zebrafish as a model for FEVR Lucia Caceres, Dalhousie University, Canada P-001 amyotrophic lateral sclerosis Olfat Abduljabbar, SITraN, UK Cancer modeling by Transgene Electroporation in Adult Zebrafish Scott Callahan, Memorial Sloan Kettering Cancer The role of protein tyrosine phosphatase oxidation in zebrafish caudal P-026 (TEAZ) Center, USA P-002 fin regeneration Maaike Allers, Hubrecht Institute, The Netherlands Circulating tumor cell clusters in melanoma metastasis: a quantitative Nathaniel Campbell, Memorial Sloan Kettering P-003 Defining the role of DLST in MYCN-driven neuroblastoma Nicole Anderson, University of Pennsylvania, USA P-027 intravital approach using zebrafish Cancer Center, USA
P-004 Genetic approaches to study the role of BAP1 in melanoma Viviana Anelli, Cibio-University of Trento, Italy Mycobacteria actively avoid neutrophil recruitment and phagocytosis Sergio Candel Camacho, University of Cambridge, P-028 at the initial infection sites by inducing lipoxin production in tissue- resident macrophages UK P-005 Modelling Diamond-Blackfan Anemia in the zebrafish Aurore Anton, Universite Paul Sabatier, France Sub-functionalisation and analysis of alternative splicing in zebrafish P-006 A zebrafish model for Pontocerebellar Hypoplasia Bart Appelhof, LUMC, The Netherlands P-029 reveals a requirement for jnk1 in cardiac development and left-right Bill Chaudhry, Newcastle University, UK patterning Liposomes targeting the blood brain barrier in vivo Gabriela Arias-Alpizar, Leiden University, The P-007 Netherlands Macrophages modify tumour angiogenesis in zebrafish xenograft Quanchi Chen, Institute of Biology, Leiden P-030 model University, The Netherlands Long-term in vivo imaging reveals tumor-specific dissemination and Nandini Asokan, Centre for Regenerative Therapies, P-008 captures dynamic tumor interaction in zebrafish xenografts Dresden, Germany Comparative transcriptomic analysis of anti-fatty liver action of Bo Chen, Institute of Medicinal Biotechnology, P-031 berberine in a diet induced larval zebrafish model China P-009 Shp1 phosphatase signaling in vivo in a zebrafish model Petra Bakker, Hubrecht Institute, The Netherlands In vivo assessment of hair cell damage and developmental toxicity June Choi, Korea University Ansan Hospital, South Calcium uptake in mitochondria of zebrafish measured in vitro Michal Bazala, International Institute of Molecular P-032 caused by PM 2.5 exposure using zebrafish (Danio rerio) models Korea P-010 and Cell Biology in Warsaw, Poland Homology-directed knockin of the dnm2a S619L mutation in zebrafish P-011 Screening for osteogenic compounds using the zebrafish as a model. Jan Willem Bek, Ugent, Belgium P-033 Sandra Coppens, ULB, Belgium Fishing for new insights into trained immunity Hannah Darroch, University of Auckland, New P-012 Transplantation cancer models : Zebrafish vs Mice Manuel Bernabe-Garcia, IMIB-Arrixaca, Spain P-034 Zealand P-013 Functional relevance of noncoding region mutations in genetic Shipra Bhatia, MRC Human Genetics Unit, Zebrafish GNE depletion and the development of a model system for Alon Daya, School of Marine Sciences, Ruppin disorders University of Edinburgh, UK P-035 GNE Myopathy Academic Center, Israel
P-014 Amyloid beta42-induced Interleukin-4 regulates neural stem cell Prabesh Bhattarai, DZNE, Germany Disturbed proteostasis in a zebrafish model for USH2A-associated Erik de Vrieze, Radboud University Medical Center, plasticity after neurodegeneration in adult zebrafish brain P-036 retinal dysfunction The Netherlands
Two populations of hematopoietic stem/progenitor cells emerge from Sasja Blokzijl-Franke, Hubrecht Institute, The In vivo validation of phage therapy against Pseudomonas aeruginosa Gianluca Deflorian, Istituto FIRC di Oncologia P-015 the hemogenic endothelium during zebrafish hematopoiesis Netherlands P-037 infections using zebrafish as a new model for cystic fibrosis Molecolare (IFOM), Italy Repurposing FDA-approved host-directed drugs for tuberculosis P-016 Ralf Boland, IBL Leiden University, The Netherlands CYYR1 gene involved in zebrafish skeletal muscle development and Gianluca Deflorian, Istituto FIRC di Oncologia treatment via autophagy modulation P-038 neuromasts differentiation: potential role in rhabdomyosarcoma disease Molecolare (IFOM), Italy P-017 Screening assays in zebrafish using vast bioimager™ Rico Bongaarts, Union Biometrica, USA The SLE-Linked gene hip1 affects renal system and innate immunity Richard Glenn Dela Cruz, OMRF, USA MYC-driven precursor-B cell acute lymphoblastic leukemia in zebrafish: Chiara Borga, University of Oklahoma Health P-039 development in zebrafish embryos P-018 implications for oncogenesis and lymphopoiesis Sciences Center, USA Multi-model screens to identify the mechanism of arsenic induced Patrice Delaney, New York University, United Arab A new therapeutic strategy for glycogen storage disorders Cinzia Bragato, Neurological Institute Carlo Besta, P-040 toxicity Emirates (UAE) P-019 Italy Zebrafish as a model for Obesity: Altered Adipogenesis in zebrafish Marjo den Broeder, Utrecht University, The Recessive mutations of POPDC3 define a new form of limb-girdle P-041 larvae following high fat diet and developmental chemical exposure Netherlands P-020 muscular dystrophy Thomas Brand, Imperial College London, UK The ribonucleotide reductase subunit M2 (RRM2) is a druggable copy Lisa Depestel, University Ghent, Belgium Polystyrene nanoparticles activate a HPI axis-mediated stress response Nadja Brun, Woods Hole Oceanographic Institution, P-042 number driven dependency gene in neuroblastoma P-021 leading to behavioral changes in zebrafish larvae USA ZeCardio: a zebrafish-screening platform for cardiovascular disease Vincenzo Di Donato, ZeClinics, Spain ALDH2 regulates the melanocyte stem cell lineage Hannah Brunsdon, Institute of Genetics and Molec- P-043 genetic association studies P-022 ular Medicine, University of Edinburgh, UK Generation and functional characterization of zebrafish knock-out Margo Dona, Radboud University Medical Center, RBM8A deficiency in TAR syndrome impacts the lateral plate meso- Alexa Burger, Institute of Molecular Life Sciences, P-044 models to study paragangliomas The Netherlands P-023 derm University of Zurich, Switzerland CRISPR/Cas9 genome editing to generate new zebrafish models of Dupuis Eleonore, ULB, Belgium Loss of the chromatin modifier Kdm2aa affects transcriptional control P-045 centronuclear myopathy P-024 in zebrafish embryos and causes BrafV600E-independent spontaneous Elisabeth Busch-Nentwich, Wellcome Trust Sanger melanoma in adulthood Institute, UK The zebrafish facial lymphatic network is formed from distinct venous Tiffany Eng, The University of Auckland, New P-046 and non-venous progenitor populations Zealand
Gba deficiency confers resistance to mycobacterial infection Jingwen Fan, Department of Cambridge, University P-047 of Cambridge, UK
The Role of ATF6a in Achromatopsia: Generation and characterization P-048 of an atf6a knockout zebrafish model Julia Felden, University of Tuebingen, Germany ......
25 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 26 CONFERENCE PROGRAM CONFERENCE PROGRAM ...... Poster Session 1 Poster Session 2 Wednesday, July 11th, 2018 Thursday, July 12th, 2018 First Floor Foyer First Floor Foyer 12:00PM - 2:00PM 12:00PM - 2:00PM Poster Poster No. Title Presenter No. Title Presenter Modelling the role of the Telomerase in skin carcinoma Miriam Fernandez-Lajarin, IMIB-Arrixaca, Zebrafish with disruption of the thyroid hormone activating enzyme P-049 Spain P-070 deiodinase type 2 show signs of insulin resistance. Anne Houbrechts, KU Leuven, Belgium
Real-time in vivo visualization of autophagic defence against Invasive Gabriel Forn-Cuni, Leiden University, The Comparative analysis of antiseizure drugs in a dravet and episodic P-050 Aspergillosis Netherlands P-071 ataxia with epilepsy zebrafish models Kingsley Ibhazehiebo, University of Calgary, Canada
Understanding the role of GDP-fucose synthesis in blood vessel stability Elucidating the mechanisms governing neutrophil reverse migration P-051 using zebrafish models Gerissa Fowler, St. Johns, Newfoundland P-072 in zebrafish Hannah Isles, University of Sheffield, UK
P-052 Proteomics analysis of extracellular matrix remodeling during zebrafish Anna Garcia Puig, CMRB, Spain Innate immune response to trypanosome infection in zebrafish Sem Jacobs, Wageningen University, The heart regeneration P-073 Netherlands Telomerase lncRNA recruits RNA polymerase II to target genes to promote Jesus Garcia-Castillo, Instituto Murciano de P-053 myelopoiesis Investigacion Biosanitaria, Spain The improvement efficacy of Cuscutae Semen and Rehmania Radix in P-074 tinnitus animal model Seo Yule Jeong, Kyung Hee University, South Korea Generating zebrafish models for Barrett's Esophagus and Adenocarcinoma Jesus Garcia-Castillo, Instituto Murciano de P-054 of the Esophagus Investigacion Biosanitaria, Spain Ageing zebrafish carrying mutations in osteoarthritis susceptibility P-075 genes display vertebral column abnormalities Erika Kague, University of Bristol, UK P-055 Modeling pediatric type I interferonopathies in zebrafish Diana Garcia-Moreno, UMU, Spain P-076 Brain haemorrhage and Hedgehog Signalling in the zebrafish Sowjanya Kallakuri, LKC,NTU, Singapore P-056 Mutations in the FGF pathway cause reduced bone and cartilage growth in Liesbeth Gebuijs, Radboudumc, The the craniofacial region of zebrafish larvae Netherlands P-077 The effects of transient MEIS1 knock-down on sleep in larval zebrafish Karl Karlsson, Reykjavik University, Iceland
Near patient zebrafish uveal melanoma PDX model for therapeutic strategy Arwin Groenewoud, Leiden University, The Understanding the role of SAMHD1 in haemorrhagic stroke Paul Kasher, University of Manchester, UK P-057 development Netherlands P-078 uZMount: A high throughput millifluidic platform for zebrafish-based P-079 Role of CHD7 in neuronal network development Betelhem Kassa, INRS, Canada P-058 screening Yadir Guerrero, Neofluidics LLC, USA Identification of neurodevelopmental phenotypes resulting from mutations P-080 Neurodevelopmental and behavioral abnormalities in Zebrafish model Magdalena Kedra, International Institute of P-059 in genes associated with autism Tripti Gupta, NICHD/NIH, USA of Tuberous Sclerosis Complex Molecular and Cell Biology in Warsaw, Poland Notch inhibition rescues cardiovascular phenotype in zebrafish with kabuki P-081 Diabetic pdx1-mutant zebrafish for modeling metabolic and late Robin Kimmel, University of Innsbruck, Austria P-060 syndrome Angie Serrano, University of Utah - EIHG, USA disease phenotypes. Anticancer drug discovery using zebrafish allograft model: Genta Kinoshita, Mie University Graduate School of Poster Session 2 P-082 Repositioning of flubendazole for the treatment for melanoma Medicine, Japan Thursday, July 12th, 2018 Changes in gene expression for rapid whole-body monitoring of drug Barbara Klotz, University of Wuerzburg, Germany First Floor Foyer P-083 effects in fish cancer models 12:00PM - 2:00PM Bone inhibitory and immunosuppressive effects of prednisolone in P-084 zebrafish Franziska Knopf, TU Dresden, CRTD, Germany Siobhan Crilly, The University of Manchester, P-061 Using zebrafish larvae to model haemorrhagic stroke UK P-085 Genetic analysis of anxiety-related behavior in zebrafish Yuri Kotani, National Institute of Genetics, Japan Tight regulation of autophagy is essential for zebrafish heart regeneration Mohankrishna Dalvoy, Ulm University, P-062 Germany Prokinetic effect of diatrizoate meglumine (GASTROGRAFIN®) for Soonil Koun, Korea University Ansan Hospital, P-086 opioid-induced constipation model in zebrafish South Korea The side population assay enriches for leukemia stem cells in zebrafish Jill de Jong, University of Chicago, USA P-063 T-ALL Hide and Seq: Characterizing epigenomic changes during melanoma P-087 initiation Eva Kramer, Washington University in St. Louis, USA Apoptosis assay optimization for Biosorter mediated drug screening of p53 Michelle Gurrola-Gal, DalhoUSAie University P-064 apoptosis restorative agents. & IWK Health Centre, Canada Hexb mutations related to GM2 gangliosidosis give rise to early P-088 lysosomal alterations in glia Laura Kuil, ErasmUSA MC, The Netherlands P-065 Manipulation of Tribbles to investigate effects on infection outcomes in Ffion Hammond, University of Sheffield, UK Characterization of a novel zebrafish system to assess cancer-associat- zebrafish models P-089 ed heart failure Rajiv Kumar, Mayo Clinic, USA P-066 Assembly dynamics and downstream effectors of the inflammasome in fish Eva Hasel, EMBL, Germany P-090 Novel perivascular cell population in juvenil zebrafish kidney Christelle Langevin,TEFOR, USA P-067 Human-zebrafish xenograft platform for individual drug response prediction Anja Heeren-Hagemann, Charite, Germany in acute lymphoblastic leukaemia (ALL ZeFiX) Zebrafish (Danio rerio) as a model to study the pathophysiological role P-091 of the mitochondrial chaperone TRAP1 Claudio Laquatra, University of Padua, Italy P-068 Zebrafish xenografts as a model to study the effect of autophagy modula- David Hill, Newcastle University, UK tion on survival and metastasis of drug-resistant human melanoma Aged vertebrate brains show a conserved failure to respond to hypoxia P-092 - a metabolic foundation for Alzheimer's disease? Michael Lardelli, University of Adelaide, Australia P-069 Identification of bioactive fungal secondary metabolites through activity Jelmer Hoeksma, Hubrecht Institute, The guided purification using zebrafish embryos Netherlands A zebrafish sarcoma shelf screen elucidates PAX3-FOXO1 cell lineage Collette LaVigne, University of Texas Southwestern P-093 tolerance and transformation capacity Medical Center, USA
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27 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 28 CONFERENCE PROGRAM CONFERENCE PROGRAM ...... Poster Session 2 Poster Session 2 Wednesday, July 11th, 2018 Wednesday, July 11th, 2018 First Floor Foyer First Floor Foyer 12:00PM - 2:00PM 12:00PM - 2:00PM Poster Poster No. Title Presenter No. Title Presenter CRISPR/Cas9-induced mutations in zebrafish CS/DS glycosyltransferase Purkinje neuron specific tunable co-expression system allows for cerebellar Kazuhiko Namikawa, TU Braunschweig, P-094 genes - effects on glycosylation, morphology and transcriptome Johan Ledin, Uppsala Universitet, Sweden P-117 neurological disease modeling in zebrafish Germany
Development of monitoring technology for sensory hair cells in the Generation of Lamin A/C zebrafish CRISPR/Cas9 mutants to model striated P-095 zebrafish lateral line using new sound exposure system DaeHyeok LEE, Hanyang University, South Korea P-118 muscle laminopathies Hannah Nicolas, University of Ottawa, Canada
Individual zebrafish larvae as model to investigate the adaptive NFkB signalling is a key regulator for a trophic inflammatory response P-096 metabolic pathways in Gaucher disease Lindsey Lelieveld, Leiden Institute of Chemistry, USA P-119 during tumour initiation Nikolay Ogryzko, University of Edinburgh, UK
Systems toxicology approach for the assessment of zebrafish cardiac Drug discovery in a zebrafish model of nemaline myopathy Boyang Qiu, University of Toronto, Canada P-097 and neurotoxicity Roman Li, Philip Morris International, Switzerland P-120
P-098 A zebrafish model to study the role of mitochondrial calcium uptake in Elisa Lidron, University of Padua, Italy Poster Session 3 physiological and pathological conditions Friday, July 13th, 2018 fndc3a, a novel split-hand/foot malformation candidate gene, First Floor Foyer P-099 influences median fin fold development and caudal fin regeneration in Daniel Liedtke, University of Wurzburg, Germany zebrafish by cell matrix alterations 12:00PM - 2:00PM
Exploring the role of Jagged-Notch signaling for organ size control and Yi-Wen Liu, Tunghai University, Taiwan mTOR promotes resistance to mycobacterial infection by supporting P-100 steroidogenesis of the interrenal gland P-121 macrophage homeostasis and infection-associated glucose metabolism Antonio Pagan, University of Cambridge, UK
Isolation of high-quality RNA from fluorescent activated cell sorted Siebe Loontiens, Ghent University, Belgium Embryotoxicity and hair cell Ddmage of sodium hypochlorite in zebrafish Kyoung Ho Oh, Korea University Ansan Hospi- P-101 (FACS) zebrafish cells for RNA sequencing purposes P-122 tal, South Korea
Microbiota composition and susceptibility towards intestinal Adria Lopez Nadal, Wageningen University and An automated high content screening platform for identification of cystic Gunjan Pandey, University of Heidelberg, P-102 enterocolitis Research, The Netherlands P-123 kidney disease-modifying substances in zebrafish Germany
PGE2 production at sites of tissue injury promotes an anti- Chemical screening for anti-infectives in zebrafish reveals a novel role for Margarita Parada-Kusz, Broad Institute of MIT P-103 inflammatory neutrophil phenotype and determines the outcome of Catherine Loynes, University of Sheffield, UK P-124 iGluRs in innate immunity and Harvard, USA inflammation resolution in vivo Inflammatory Cells Breach the Basement Membrane to Interact with P-125 Development of a phenotypic zebrafish (Danio rerio) model for Nie- Ard Peeters, Chardon Pharma, The Neth- P-104 Pre-Neoplastic Clones at Early Stage of Skin Cancer Development Lucy Maccarthy-Morrogh, Bristol University, UK mann-Pick Type C disease erlands Epigenetic reprogramming induced by UHRF1 overexpression causes P-126 Pharmacological inhibition of the inflammasome for anemia of chronic Ana Belen Perez-Oliva, University of Murcia, P-105 liver cancer in zebrafish Filippo Macchi, NYUAD, United Arab Emirates (UAE) disease treatment Spain
DNA hypomethylation and Nuclear Re-organization Restrict bhavani madakashira, New York University Abu P-127 Mito-Stat3 regulates cell proliferation by promoting mitochondrial gene Margherita Peron, University of Padua, Italy P-106 Proliferation of uhrf1 Deficient Zebrafish Hepatocytes Dhabi, United Arab Emirates (UAE) expression Zebrafish as a new model to study Telomerase-independent telomere P-128 NIPBL, a new player with NPMc+ in the onset of Acute Myeloid Leukemia Anna Pistocchi, University degli Studi di P-107 maintenance mechanism: regeneration and cancer Elena Martinez-Balsalobre, IMIB-Arrixaca, Spain Milano, Italy Vitamin B6 plays a crucial role in psoriasis Francisco Juan Martinez-Navarro, Universidad de P-129 Anticonvulsant properties of galanin in zebrafish epilepsy model Piotr Podlasz, University of Warmia and P-108 Murcia, Spain Mazury, Poland
Zebrafish as a model for MPV17-related mtDNA depletion syndrome Laura Martorano, University of Padua, Italy A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa Lore Pottie, Centrum Medische Genetica P-109 P-130 syndrome Gent, Belgium P-110 A novel role for the SNARE protein Snap29 in nervous system devel- Valeria Mastrodonato, University of Milan, Italy In vivodynamics of canonical and non-canonical anti-staphylococcus aureus opment P-131 autophagy in larval zebrafish Tomasz Prajsnar, University of Sheffield, UK P-111 Neural crest transcription factors induce reactivation of neural crest Alicia McConnell, Boston Children's Hospital, USA Automated in vivo screen of a zebrafish melanoma model identifies FDA- Francesca Precazzini, CIBIO (Centre for progenitor cell fate in adult zebrafish P-132 approved drugs for combinatorial treatments Integrative Biology), Italy P-112 kcna1a mutant zebrafish exhibit signs of ataxia, bioenergetics defects Paola Meza Santoscoy, University of Calgary, Canada Modeling human intellectual disability and autism: role of the chromatin and impaired startle response P-133 regulator setd5 during zebrafish brain development Cecilia Pucci, University of Pisa, Italy P-113 Nuclear pore formation as a potential target for hepatocellular carci- Kimberly Morgan, Walter and Eliza Hall Institute, Deciphering histone deacetylase 6 (HDAC6) interaction with human Tau noma (HCC) therapy Australia P-134 using zebrafish Celia Quevedo, Biobide, Spain P-114 LC3-Associated Phagocytosis (LAP) during host defense against Salome Munoz Sanchez, Leiden University, The Role of Elk1 in congenital and late onset cardiac disease: at the heart of Mirana Ramialison, Australian Regenerative Tuberculosis Netherlands P-135 the matter Medicine Institute, Australia P-115 Characterization of in vivo functions of DNA repair genes USAing Kyungjae Myung, IBS/Center for Genomic Integrity, Generation and characterization of cnga3- and cngb3-knockout zebrafish as Peggy Reuter, University of Tuebingen, zebrafish CRISPR mutants South Korea P-136 animal models for achromatopsia (ACHM) Institute for Ophthalmic Research, Germany
P-116 Dried Rotifer Sheet: a novel live feed for rearing first-feeding larvae Hiroko Nakayama, Mie university, Japan Dipeptide repeats produced by the c9orf72 repeat cause P-137 neurodegeneration in a zebrafish model for amyotrophic lateral sclerosis Frederike Riemslagh, Erasmus MC, The and frontotemporal dementia Netherlands
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29 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 30 CONFERENCE PROGRAM CONFERENCE PROGRAM ...... Poster Session 3 Poster Session 3 Friday, July 13th, 2018 Friday, July 13th, 2018 First Floor Foyer First Floor Foyer 12:00PM - 2:00PM 12:00PM - 2:00PM Poster Poster No. Title Presenter No. Title Presenter The pituitary gonadotropin Fsh modulates the self-renewal/ Zebrafish as a model for pancreatic ductal adenocarcinoma Thijs van Boxtel, Memorial Sloan Kettering Cancer P-138 differentiation spermatogonial balance by using both canonical and Diego Safian, Utrecht University, The Netherlands P-161 Centre, USA non-canonical Wnt signaling Nanoscale blood sampling from zebrafish larvae at 5 days post Rob Van Wijk, LACDR, Leiden University, The Identification of novel inhibitors of activated Wnt/β-catenin signaling Imelda Sandoval, Oklahoma Medical Research P-162 fertilization to quantify paracetamol blood concentrations Netherlands P-139 using zebrafish-based phenotype screens Foundation, USA Antisense oligonucleotide-induced skipping of USH2A exon13 restores Erwin Van Wijk, Radboud University Medical Center, Characterizing metastatic proliferative microenvironments in vivo P-163 visual function in zebrafish The Netherlands P-140 using xenografted Ewing sarcoma cell biosensors in zebrafish David Saucier, UT Southwestern, USA Classification of LMNA-variants by means of zebrafish phenotyping A mitochondrial therapy for Duchenne muscular dystrophy Marco Schiavone, University of Padova, Italy Jo Vanoevelen, Maastricht University Medical P-141 P-164 Center, The Netherlands A novel zebrafish model of congenital neutropenia and Shwachman- Christoph Schürch, Department of Biomedicine, P-142 Diamond-like phenotype University Hospital Basel, Switzerland P-165 Using zebrafish larvae to study Klebsiella pneumoniae pathogenesis Macarena Varas, Universidad de Chile, Chile
Studies on skeletal muscle atrophy in space -what zebrafish Atsuko Sehara-Fujisawa, Kyoto University, Japan Mycobacteria trigger gasdermin-dependent pyroptotic cell death of P-143 experienced in a space tour P-166 macrophages to disseminate the infection Monica Varela, Leiden University, The Netherlands
Overlap of SEC23A and SEC23B paralog function suggests a novel Jordan Shavit, University of Michigan Medical Uncovering the role of atm in zebrafish Jeroen Vierstraete, Center for Medical Genetics P-144 therapeutic approach for congenital dyserythropoietic anemia type II School, USA P-167 Ghent, Belgium
Analysis of Shh signaling on radial glia proliferation and differentiation Yuki Shimizu, Waseda University, Japan Ezh2 positively regulates the circadian clock and hematopoiesis P-145 after stab injury in the adult zebrafish optic tectum P-168 independent of histone methyltransferase activity in zebrafish Han Wang, Soochow University, China In vivo optical mapping of cardiac action potentials in zebrafish larvae Ewa Sieliwonczyk, University of Antwerp, Centre of P-146 Medical Genetics, Belgium Investigating the molecular crosstalk between stromal adipocytes and Joshua Weiss, Sloan Kettering Institute for Cancer P-169 melanoma to identify new therapeutic targets Research, USA Novel zebrafish models of sarcoglycanopathy Michela Soardi, University of Padova, Italy P-147 Hemicentin-1 is required for myotendinous junction stability both in Daniela Welcker, Institute for Developmental P-170 zebrafish and mouse. Biology, Germany Understanding the role of DHX15, a DEAH box helicase, in acute Raman Sood, NHGRI/NIH, USA P-148 myeloid leukemia using CRISPR/Cas9 in zebrafish Loss of amino-acylation capacity is not the sole determinant for development of Charcot-Marie-Tooth disease type 2N : identification of Functional analysis of 17q-dosage sensitive dependency genes in the P-171 three novel pathogenic missense mutations in the gene for alanyl-tRNA Marian Weterman, LUMC, The Netherlands P-149 dbh-MYCN driven zebrafish neuroblastoma model Frank Speleman, University Ghent, Belgium synthetase.
Role of the intracardiac nervous system in stress-induced arrhythmias Carboxypeptidase N1 controls vascular patterning during zebrafish Chang-Yi Wu, National Sun Yat-sen University, P-150 with Popdc1 gene mutation Matthew Stoyek, Dalhousie University, Canada P-172 development Taiwan P-151 Effects of aging on cardiac function in zebrafish Matthew Stoyek, Dalhousie University, Canada MiR-145 regulates Progranulin A/MET signaling in zebrafish hepatic Jen-Leih Wu, Institute of Cellular and Organismic P-173 growth and regeneration Biology, Academia Sinica, Taiwan Launching the Austrian platform for compound screening on zebrafish Caterina Sturtzel, Children's Cancer Research P-152 disease models Institute, Austria The gonadal soma controls ovarian follicle proliferation through Gsdf YiLin Yan, Institute of Neuroscience, University of P-174 in zebrafish Oregon, USA Neutrophil nitric oxide is protective in a zebrafish model of TB P-153 Piotr Szkuta, University of Sheffield, UK Dahai Yang, East China University of Science and P-175 Unlocking the non-canonical inflammasome activation in zebrafish Technology, China P-154 The schistosoma granuloma in a larval zebrafish model Kevin Takaki, University of Cambridge, UK Stage-dependent roles of autophagy on liver tumorigenesis in zebrafish Qiqi Yang, National University of Singapore, Analysis of intra-macrophage stages of Burkholderia cenocepacia P-176 Singapore P-155 using the zebrafish model Yara Tasrini, INSERM, France P-177 A zebrafish screen to assess immunotoxicity by chemical exposure Jeffrey Yoder, North Carolina State University, USA P-156 The role of interleukin 10 in innate immune defences in zebrafish Gillian Tomlinson, Unversity College London, UK mycobacterial infection Palmaria mollis exerts anti-obesity effects in zebrafish and mice by P-178 inhibiting lipogenesis and promoting lipolysis Liqing Zang, Mie University, Japan P-157 Zebrafish as a model for dissecting the mechanisms involved in Colla- Valentina Tonelotto, University of Padova, Italy gen VI functions during embryonic and postnatal development Elevated Wnt signaling induced an extra liver lobe in zebrafish Hanbing Zhong, Southern University of Science and P-179 Technology, China P-158 Conditional control of MITF reveals new subpopulations triggering Jana Travnickova, MRC IGMM/ University of melanoma recurrence in vivo Edinburgh, UK mTOR kinase controls neuronal development in zebrafish retina Justyna Zmorzynska, International Institute of P-180 Molecular and Cell Biology in Warsaw, Poland A metabolic interplay coordinated by HLX regulates myeloid Eirini Trompouki, Max Planck Institute of Immuno- P-159 differentiation biology and Epigenetics, Germany P-181 Glucocorticoid modulation of the inflammatory response Yufei Xie, Leiden University, The Netherlands Immature cardiomyocytes in the adult zebrafish heart and their role in Ayele Taddese Tsedeke, Max Planck Institute for P-160 cardiac regeneration Heart and Lung Research, Germany
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31 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 32 CONFERENCE EXHIBITOR FLOOR PLAN ...... 8 9 7 10 6 11
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33 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 34 CONFERENCE EXHIBITORS CONFERENCE EXHIBITORS ...... Acquifer Booth #14 Life Science Methods Booth #6 At ACQUIFER – now a division of DITABIS AG – we developed the Imaging Machine, a versatile and flexible Automated microinjection and zebrafish handling by Life Science Methods products improves the high content screening platform following a unique optomechanical design. Its sample centered approach, throughput of your experiments. By using a special grid, zebrafish eggs are aligned such that microinjection including a static stage in combination with moving optics and integrated environmental control, provides can take place at an unprecedented speed. optimal in vivo imaging conditions and renders it ideal for image-based screening or parallel long-term www.lifesciencemethods.com observation of biological specimen such as small model organism.
www.acquifer.de Neofluidics Booth #3 Neofluidics develops next-generation tools and technology for small animal screening. Our engineering- Aquaneering, Inc. Booth #2 driven products add unprecedented convenience and efficiency to the workflows, significantly reducing the Aquaneering is an internationally recognized leader of aquatic housing for zebrafish, Xenopus frogs, and cost of testing, measurement and analysis. other aquatic species used in medical research, and the manufacturer of the largest zebrafish systems in www.neofluidics.com the world. Aquaneering offers unmatched knowledge of highly advanced filtration technologies pioneered within the aquaculture industry, notably no-maintenance filters that provide undetectable levels of Nikon Booth #18 ammonia and nitrites. Nikon is a world leader in optical devices. Several instruments are developed for researchers active in bio www.aquaneering.com research. These products cover the microworld and the nanoworld and allow qualitative and quantitative imaging. Looking at single cells or doing highly efficient smart high content screening are part of our ChemBridge Corp. Booth #17 customer tailored solutions. ChemBridge Corp. provides chemistry products and services for small molecule drug discovery and www.nikoninstruments.com chemical biology including 1.1 million screening compounds, 14,000 building blocks, and research-intensive custom library and synthetic/medicinal chemistry services. Noldus Booth #5 www.chembridge.com Noldus Information Technology develops, markets and supports professional software and instrumentation for animal behavior research. These products enable the collection, analysis, management, and Danio Data Booth #11 presentation of behavioral data. Our products range for neuroscience research includes EthoVision XT, DanioDataTM by Fulcrum is the first portable relational database for Apple devices created specifically for a video tracking tool, and The Observer XT for behavior annotation. Additionally, CatWalk XT is used zebrafish research and features interactive digital facility maps detailing locations of every single tank; for footprint and gait analysis, ErasmusLadder for cerebellar phenotyping, and PhenoTyper for home QR code scanning, and instant label printing. It offers searchable accurate data of Danio-rerio stocks/ cage testing. DanioScope is the tool for measurements of zebrafish embryo and larvae, DanioVision for strains, and Lab Notebooks tracking: symptoms, morbidities/mortalities, protocols and more. Simply scan monitoring zebrafish larvae activity, and Track3D is a video-based system for automated tracking of animals water-proof labels for updated tank details: health history, statistics, water conditions, feeding schedules in a three-dimensional space. and recipes. Introducing new removable laser printer designed labels that transform the labor-intensive www.nolduszebrafish.com complex graffiti of tape and markings into clean individualized color-coded, hand scannable labels. Extensive notifications capabilities. Expanded PI’s and Lab Manager’s tools/accounting. Tecniplast Booth #9 www.daniodata.com Tecniplast is the leading provider of aquatic research systems, with unique capabilities in design, engineering and manufacturing. Our products include housing systems, various breeding solutions, washing Future Genomics Technologies B.V. Booth #19 systems, automated feeding and more. Future Genomics Technologies is at the cutting edge of sequencing and bioinformatics technology and our www.tecniplast.it customers can benefit from the latest developments in genomics. Our expertise includes genome assembly from Nanopore reads, transcriptome profiling and the bioinformatics analysis that are needed to get access TEFOR Infrastructure Booth #15 to the results of your project. TEFOR is a distributed infrastructure gathering several platforms. By integrating scientific and technical www.futuregenomics.tech progress performed on genome editing and phenotyping (mainly 3D & 3D+t imaging), and thanks to a centralized management, TEFOR provides the highest quality of services and resources with reduced Leica Microsystems Booth #16 administrative red tapes. By this, TEFOR is of major interest for providing Europe with a distributed Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis infrastructure to support both public and private research. of microstructures and nanostructures. Ever since the company started as a family business in the 19th https://tefor.net/ century, its instruments have been widely recognized for their optical precision and innovative technology. It is one of the market leaders in compound and stereo microscopy, digital microscopy, and confocal laser Thermo Fisher Scientific Booth #13 scanning microscopy with related imaging systems, electron microscopy sample preparation and surgical Thermo Fisher Scientific is the world leader in serving science. Our Life Science business serves both microscopes. Leica Microsystems has seven major plants and product development sites around the world. academic and industrial life sciences researchers, providing an unmatched combination of complete The company is represented in over 100 countries, has sales and service organizations in 20 countries and workflow solutions ranging from cryo-EM structural determination of macromolecular complexes and an international network of distribution partners. protein sociology, in the native state, to reconstruction of 3D architecture of tissues and cells. Our solutions www.leica-microsystems.com help researchers unlock the mysteries of underlying protein function and cellular process and bridge the gap between basic science and translational therapeutics. www.thermofisher.com/fei
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35 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 36 CONFERENCE EXHIBITORS CONFERENCE PROGRAM ...... Union Biometrica Booth #4 Tools for High Content Zebrafish Screening. The VAST BioImager™ platform automatically loads and rotationally orients 2-7 day post-fertilization zebrafish larvae for organ-level imaging. Mounts on many upright microscopes for cellular-level fluorescence imaging. Union Biometrica COPAS FP™ and BioSorter® Large Particle Flow Cytometers automate the analysis and sorting of objects too big (10-1500μm) or too fragile for traditional cytometers. Examples include zebrafish eggs & larvae as well as other small model organisms and large cells/cell clusters. www.unionbio.com let’s talk! Write us at Viewpoint Behavior Technology Booth #10 Viewpoint has developed the worldwide leading system for Zebrafish Behavior Analysis. As pioneer in Zebrafish highthroughput behavioral screening, Viewpoint launched in 2003 its first Zebralab system, which [email protected] consists in an innovative software used either with our Zebrabox for larvae or our Zebracube for adults. Visit our website to see our applications such as 3D, Heartbeat and Bloodflow, Virtual Prey, Optokinetic Response (OKR), C-shape, S-shape…Our Zebralab system is user-friendly and custom-made for special applications. www.viewpoint.fr
World Precision Instruments Booth #12 Serving scientists for over 50 years, WPI offers a variety of instruments for microinjection including pumps, pipetters, microscopes and more. One of our most popular pumps for microinjection is the PV820 Pneumatic PicoPump. The PV820 and PV 830, Pneumatic PicoPumps, were designed to simplify intracellular injection. You get repeatable microinjection in volumes ranging from picolitres to nanolitres. PV820 offers eject and hold pressure. The hold pressure prevents backfilling of the pipette by capillary action. In addition, the PV830 also has vacuum pressure which allows you to securely hold a cell with one pipette • High throughput sorting while you inject it with another. into well plates www.wpi-europe.com
Zantiks Ltd. Booth #1 • Deep learning approach • Single egg dispensing Zantiks produces affordable equipment to enable animal behaviour to be measured simply. Zantiks units are fully integrated with a computer, software, camera and built-in stimuli to easily automate zebrafish studies. Fully networked, each unit is operated from any connected device where users can track and brafish egg download real-time data and video. Larval zebrafish are monitored in the temperature-controlled Zantiks Ze s MWP unit. The Zantiks AD unit runs standard protocols for adult zebrafish behavioural monitoring and learning experiments. www.zantiks.com
Zebcare Booth #7 Planktovie’s vision is to develop nutritional solutions meeting the highest standards for the maintenance of zebrafish, and helping to fulfill the 3Rs principles in relation with animal experimentation. Skretting GEMMA Micro is a unique, patented diet that offers complete nutrition for every lifestage of zebrafish. Feeding GEMMA Micro for the entire life cycle of zebrafish leads to healthy, robust, and highly fecund zebrafish. ZEBCARE is your full-service provider in zebrafish husbandry technology with a unique approach. All our projects are customized, based upon the specific requirements of the customer. www.fleuren-nooijen.nl
Zeiss Booth #8 ZEISS is a technology enterprise operating globally in the fields of optics and optoelectronics. It emerged from a workshop for precision mechanics and optics which was established by company founder Carl Zeiss in the east German city of Jena in 1846. Today, ZEISS is headquartered in Oberkochen in the southwest of Germany. ZEISS plays an active part in advancing technology and propels the world of optics and other Early embryonic stage classification related fields to new heights of excellence with its leading-edge solutions. The ZEISS mission statement is: “As the pioneer of science in optics, we continue to challenge the limits of our imagination. With our passion for excellence, we create value for our customers and inspire the world to see in new ways.” enabled (cleavage periode) ! ...... www.zeiss.com ......
37 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2017 | Leiden, NL 30 The Stem Cell program at Boston Children’s Hospital brings together premier physicians from many backgrounds and specialties to form one of the top stem cell research units in the world. Their research holds extraordinary potential for the development of therapies that may change the future for children throughout the world.
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