CONFERENCE PROGRAM CONFERENCE PROGRAM zdmsociety.org/zdm11 THANK YOU TO OUR SUPPORTERS! WELCOME TO ZDM11 ........................................................................................................................................................................................................................................................................... Dear ZDM11 Attendees, GOLD Welcome to Leiden! We are delighted to host the zebrafish community for the 11th Zebrafish Disease Models Conference, particularly because Leiden hosted what turned out to be the first ZDM Conference in 2007, ZDM1! Leiden has had an active zebrafish community for over two decades with strong ties to the Hubrecht Institute in Utrecht and practically all other universities in the Netherlands, most of which are less than an hour away. ...................................................................................................................................................................................................................................................... Leiden University was founded in 1575, is the oldest university in the Netherlands and is one SILVER of Europe’s leading international research universities. In addition, Leiden University campus, where the conference takes place, is home to Leiden Bio Science Park, the largest life sciences cluster in the Netherlands. Next to the university, there are more than 100 dedicated medical life sciences companies and institutions located close together, including several multinational ....................................................................................................................................................................................................................................................... and internationally acclaimed research institutes. RECEPTION SPONSOR Leiden is a typical university city with university buildings scattered throughout the city. The many students from all over the world give the city a bustling, vivid and international atmosphere. The downtown area is riddled with bars and restaurants, with something for everyone’s liking. ....................................................................................................................................................................................................................................................... We look forward to an inspiring and interactive conference with cutting edge science and social CONTRIBUTORS activities alike. Please, enjoy the conference in all its facets. Warm regards, ....................................................................................................................................................................................................................................................... The ZDM11 Local Organization Committee EXHIBITORS Herman Spaink, Jeroen den Hertog, Marcel Schaaf, Ph.D. Ph.D. Ph.D. Ewa Snaar-Jagalska, Fons Verbeek, Sonja Wijfjes-Chang Ph.D. Ph.D. WORLD PRECISION INSTRUMENTS Instrumenting scientific ideas .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 2 TABLE OF CONTENTS WELCOME TO ZDM11 .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... July 10, 2018 Supporter Appreciation 1 I am excited to welcome all of you to Leiden for ZDM11, the 11th Zebrafish Disease Models Welcome to ZDM11 2 conference. Contents 3 As many of you know, this is not the first ZDM meeting to take place in Leiden. Indeed, the inaugural meeting, ‘Model Systems for Infectious Disease and Cancer in Zebrafish’, was held here Letter from the ZDMS President 4 in July 2007 with 42 participants and by all accounts it was fantastic. As you will see from the ZDMS Leadership 5 Program, these days the scope of ZDM conferences extends far beyond infectious disease and ZDMS RIG Leaders 6 cancer, and we will be showcasing the very best work in neurological disorders, cardiac and skeletal muscle disease, inflammatory disease and diseases of the blood, vasculature and digestive organs. Award Recipients 7 Keynote Speakers/ Social Programs 8 We are thrilled that two local luminaries, Professors Christine Mummery and Alexander van Oudenaarden, have agreed to be our Keynote speakers. I am sure their presentations will be Organ Performance by Graham Lieschke 9 amongst the highlights of the conference. Over the course of the meeting, we can also look Conference Information 10 forward to hearing from 18 terrific invited speakers who have gathered here from all around the world. Yet another high spot will be the talks from the winners of our first Junior Faculty Award for Conference Program 11 Excellence. And, in what I hope will prove to be an ingenious experiment, we will hold one of our Map of Leiden 24 plenary sessions in Pieterskerk, a local building of great cultural significance, where we will have Conference Posters 25 the opportunity to mix science with music. Exhibit Hall Floorplan 33 As we have come to expect, the local organizing committee have kept a keen eye on the social events as well as the scientific program and I would like to thank Herman Spaink, Jeroen den Exhibitors 35 Hertog, Marcel Schaaf, Ewa Snaar-Jagalska, Fons Verbeek and Sonja Wijfjes-Chang for their ZDM12 41 magnificent efforts in bringing it all together. Conference organization requires imagination, inspiration and tireless negotiation skills, and these six people demonstrated these qualities in abundance. Jeroen den Hertog and David Langenau co-chaired a Scientific Program sub-committee which drew support from the LOC, the ZDMS Board of Directors and the Chairs of the Research Interest Groups. By the end of the week, I am sure you will agree that we did a pretty good job! None of this would have been possible without the unerring support of our conference partner, Site Solutions Worldwide. I thank Sarah Hughes, Sara Aldrich, Marissa Streun, Nathalie Whitton, Lisa Cormier, Kristina Agresta and Chantal Smith for the skill and attention to detail they brought to all aspects of the meeting. I also wish to thank our generous sponsors from academia and industry, @ZDMSociety #ZDM11 especially those that have been with us for many years. So, as you can see, we have done our best to bring together all the ingredients for a truly facebook.com/zdmsociety memorable meeting – the rest is up to you! Best wishes, @ZDMSociety Joan K Heath President, Zebrafish Disease Models Society .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 3 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 11th Annual Zebrafish Disease Models Conference | July 10-13, 2018 | Leiden, NL 4 ZDMS LEADERSHIP RESEARCH INTEREST GROUP LEADERS .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... EXECUTIVE COMMITTEE CANCER President Craig Ceol, University of Massachusetts Medical School, Massachusetts, USA Joan Heath, Ph.D Richard White, Memorial Sloan Kettering Cancer Center, New York, USA The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia DRUG DISCOVERY Hui Feng, Boston University School of Medicine, Massachusetts, USA Vice President Elizabeth Patton, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom Graham Lieschke, M.B., B.S., B.Med.Sc., Ph.D, F.R.A.C.P. Australian Regenerative Medicine Institute and Royal Melbourne Hospital, Victoria, Australia EDUCATION Michael Pickart, Concordia University Wisconsin, Wisconsin, USA Christopher Pierret, Mayo