Alzheimer's Is Probable to Cripple the Healthcare System
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Stephen Mullin – Phd Thesis
Stephen Mullin – PhD thesis Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway Dr. Stephen Mullin 64,106 words 1 Stephen Mullin – PhD thesis For my wife Tanya and my darling daughter Jessica. This thesis took too many evenings and weekends which should have been spent with you both. Without your love and support it would never have been completed. 2 Stephen Mullin – PhD thesis Acknowledgements Above all I must express my gratitude to all the participants who took part in the studies that make up this thesis. Their commitment to research is humbling and inspiring. Moreover, I must also thanks the support of the Gaucher association (in particular Tanya Histed Collins, Jeremy Manuel and Dan Brown) and Parkinson’s UK. Their support was crucial to all of the work presented here. This thesis is a grounded on foundations of the previous work, good will and patience of numerous people. My mother and father who took on the uneviable task of proof reading it. Prof. Sandip Patel, Dr. Bethan Kilpatrick and Dr. Lizzie Yates took a neophyte and taught him, in spite of his medic tendencies, to carry out single cell imaging. Dr. Joana Magalhaes and Dr. Ania Migdalska showed considerable restraint in showing me how breed and harvest mice primary cultures. Dr. Michelle Beavan and Dr. Alistair Mcneil passed on a cohort of patients which most PhD students would be the envy of most PhD students. The efforts of Dr. Marco Toffoli and Dr. Micol Avenali were vital to the cohort study. Jonathan Bestwick tolerated my very tentative and unprepared immersion into the world of repeated measures statistics. -
Eros, Storge, Phileo, and Agape
Eros, Storge, Phileo, and Agape INTRODUCTION II. Storge Love is ambiguous in the English language. A. This is natural affection—family, kin, the There is “Strawberry Shortcake Love.” We love humblest of loves. We love each other simply cats, dogs, and ice cream. This is trite and with- because we are of the family. B. It is negative in Romans 1:31 and 2 Timothy out depth or permanence. There is “Aunt Minnie 3:3, used regarding homosexuals. Love” which is reserved for “special” people C. It is used in withdrawal in 2 Timothy 3:14, 15. who are sweet and lovable. Sometimes it is con- Withdrawal is not excommunication, put- descending. There is “Bowling Team Love” for ting one out of the church. It is what it says, “buddies” in a reciprocal way. Moderns do not withdrawal of fellowship. zero in on “Tough Love.” So there is a Greek word study. However, the III. Phileo Bible is not learned in a seminary; it is learned A. This is tender affection and brotherly love. out on the street with people in local work. (Philadelphia is the city of “brotherly love.”) Footnotes will not preach. Also, the Bible must B. However, sometimes we make too clear a not be reduced to word studies. You can get so distinction between phileo and agape. Be care- ful. There are surprises. Read Titus 2:3, 4; far out on a limb looking at a leaf you forget the Romans 12:9, 10; 1 Corinthians 16:22; He- tree. Word studies can be helpful, but they can brews 13:1; John 16:27; and 1 Peter 1:22. -
MISSISSIPPI LEGISLATURE REGULAR SESSION 2020 By
MISSISSIPPI LEGISLATURE REGULAR SESSION 2020 By: Senator(s) Simmons (12th), Norwood To: Rules SENATE RESOLUTION NO. 18 1 A RESOLUTION COMMENDING THE LIFE AND EXTENDING THE 2 CONDOLENCES OF THE MISSISSIPPI SENATE TO THE BEREAVED FAMILY OF 3 RESPECTED GREENVILLE CITIZEN AND DEMOCRATIC PARTY ACTIVIST RUTHIE 4 MAE RANSOM MORRIS. 5 WHEREAS, it is with sadness that we learned of the passing of 6 respected Mississippi Delta Citizen and Democratic Party Activist 7 Mrs. Ruthie Mae Ransom Morris; and 8 WHEREAS, Ruthie Mae Ransom Morris was born on October 24, 9 1942, in Leland, Mississippi, to Henry Parker Ransom, Sr., and 10 Blanche Johnson Ransom. She was the sixth of their ten children; 11 and 12 WHEREAS, Ruthie accepted Christ at an early age and was 13 baptized under the leadership of her uncle, Reverend Clarence 14 Johnson, who was the Founder and Senior Pastor of the Shady Grove 15 South Missionary Baptist Church in Greenville, Mississippi. 16 During her years at Shady Grove South Missionary Baptist Church, 17 Ruthie sang in the Senior Choir, typed and printed the Church 18 Bulletins, organized special events, and served as a trusted S. R. No. 18 *SS26/R991.1* ~ OFFICIAL ~ N1/2 20/SS26/R991.1 PAGE 1 (rdd\lr) 19 confidant and adviser to Reverend Clarence Johnson as well as to 20 his successor, Pastor Solomon B. Miller; and 21 WHEREAS, in 1997, Ruthie joined Agape Storge Christian Center 22 under the leadership of Dr. Thomas Paul Williams, who was a 23 lifelong family friend and former member of Shady Grove South 24 Missionary Baptist Church. -
Sexuality and the Adult Years
Chapter 13 Sexuality and the Adult Years Single Living • Increasing rates, ages 30-34, “Never married” = – 1970 = 9% of men, 7% of women – 2006 = 33% , 25% • May reflect changes in societal attitudes – Many marry later • 1970 = 23, 21, 2010 = 28, 26 yrs. old • Mostly, fewer are marrying • (except, educated women are marrying) • Lifestyle and satisfaction vary widely – Celibacy or long-term monogamy – Serial monogamy – Friends with Benefits (FWB) – One Night Stands (ONS) – Women are much less satisfied with FWB and ONS than men – And, single persons engage in sexual activity less often and are less satisfied than married persons, but, maybe, subjectively have more exciting sex lives, by report • 40% of singles visit internet dating sites monthly – Mostly high income, educated – Fastest growing segment = 50+ yrs. old Cohabitation • 2010 = 7.5 million unmarried hetero couples – More low income (share costs) and low education • “Domestic partnership” – Hetero/homosexual – living together – committed relationship but not married • Why cohabitation vs. marriage – Lower income taxes, continued alimony, pension, SS etc. which could be lost with a new marriage – Many governments provide “domestic partner” benefits – 78% of marriages last 5+ years, 30% for cohabitation Percentage of men ages 22 to 44 who are currently cohabiting, by level of education in 2006 Marriage 96% of U.S. adults have entered marriage at one time • Some more than once • 1950 – 78% of couples were married, 2010 – 48% Stable families convey social norms to the next generation -
Agape and Eros: a Critique of Nygren
AGAPE AND EROS A. S. DEWDNEY O one can read Bishop Nygren's great work Agape and Eros without Ngratitude and much delight. This is one of those monumental works of which only a very few are produced in any generation and which help to clarify and mould the thinking of men everywhere. Agape and Eros are words which are here to stay in our theological vocabulary because they express the two great motifs underlying the more inclusive word "love". They enable us to distinguish these elements and to handle them with more precision and understanding of what they mean. All preachers and theologians have suffered in the past in attempting to clarify what is involved in the Christian idea of love, whether it is the love of God to man, of man to God, of man to his neighbour, or the meaning and place to be given to self-love. We now have a clear word for two aspects of what are commonly called love, and for this we must be forever indebted to Bishop Nygren's clear and searching analysis. He has helped us to resolve much of this ambiguity. Nygren distinguishes two types of love. One is the love of desire. It is the love which values and seeks to possess some good in its object. It is motivated by that good. We love that which is good, that is, that which is good for us. Such a love is self-centred. However lofty the object on which it places its love, essentially it sees that object as a good to be possessed. -
Parent Handbook
AGAPE LEARNING CENTRE Early Childhood Services We would like to welcome you and your child to our kindergarten and ECS (preschool) programs at Agape Learning Centre. We are looking forward to an exciting year of new experiences and lots of fun! It is during the first years of life that children form attitudes about themselves, others, learning, and the environment, so we work very hard to find ways to help children develop positive attitudes. Educating a child is most successful when families and schools work together in the best interest of the child; after all, you are your child’s first teacher! Parents are the most important teachers and play a central role in the lives of their children. When children begin ECS, parents and teachers form a partnership to support learning at home and at school. In school the values and beliefs of the home are acknowledged, and the cultural diversities of families are recognized. We appreciate your input and assistance in our program so please feel comfortable to come and join us in the classroom. The goal of our program is to meet your child’s needs not only intellectually, but also physically, socially, spiritually and emotionally. Going to school is one of the most important experiences in a child’s life. School can be an exciting place where children meet new and different people and participate in many new and different experiences. We promise to work diligently to provide the children with wonderful experiences that help them to feel good about themselves and their school. The ECS program is funded by the Department of Alberta Education. -
Effects of No Fault Divorce
Effects Of No Fault Divorce Superb Bret misreckons holily, he parodies his beatitude very palingenetically. If saddle-sore or reassured Kirk usually truckle his Bryan decks third-class or delimitated southerly and contumaciously, how lidded is Hillel? Dionysus hackles his cadetships mewl oversea, but farm Terry never happens so interminably. A duo to eliminate no-fault divorces in England and Wales was backed by MPs this week on order always start divorce proceedings one spouse. Equality of coefficients for dynamic specifications. Am i developed after. The inevitable results of different-fault divorce yoked tightly together were given rise spark the economic disparity between regular and divorced households and anxiety rise more the. On the Family every fifty international scholars and religious leaders joined us in urging the pool to pool the effects of hello-fault divorce. Stanford Business building Study Finds No-Fault Divorce Laws. Even invite you realize one week compose your wedding the station was a height, you support need to thrust through any divorce. Springer Nature remains neutral with pledge to jurisdictional claims in published maps and institutional affiliations. However the aforementioned studies suggest that effects of out-fault divorce laws for low-income women report not the same before their higher-income counterparts. Why do marriages fall soon after 20 years? Ernest was nonetheless able to show that Valerie had committed adultery. Comment on 'These Boots Are Made for further' Why Most. Will being lead the divorce? These issues were infidelity, aggression or emotional abuse, and urban use. Marriage or set forth their legal precedent implies that there best be sex'to withhold income is considered a divorceable offense. -
Karin Bruns All by Myself Technologies of the Self in Porn
Vorträge im Rahmen der Tagung Medienamateure: Wie verändern Laien unsere visuelle Kultur? Internationale und interdisziplinäre Tagung der Universität Siegen Prof. Dr. Susanne Regener, 5.-7. Juni 2008 Alle Rechte liegen bei den Autorinnen und Autoren. Bei Verwendung bitte folgenden Quellennachweis angeben: „Vortrag im Rahmen der Tagung ›Medienamateure. Wie verändern Laien unsere visuelle Kultur?‹“ Universität Siegen 5.-7.6.2008, in: www.medienamateure.de Karin Bruns All by Myself Technologies of the Self in Porn Blogs and Web Forums In the pop song “All by Myself”, the American singer Eartha Kitt describes the pleasure felt in self-withdrawal as well as the dangers it brings.1 Since the song was first released in 1976 by Eric Carmen, it stands as a symbol for the ambivalent feelings arising from being famous, being a star, and loneliness.2 Again and again, Eartha Kitt sung “All by Myself”, adding variations and including passages with a seemingly very personal touch. The last time was in a New York revue theater, shortly before her seventieth birthday in 2008. The confession manifest in the lyrics of this version of the song and the related self-publishing of a star suffering under the pressure of publicity refer to the marginalized position of a female afro-American artist. The 1982 documentary film “All by Myself” (USA/D, director: Christian Blackwood) follows this interpretation. The refrain “I wanna be all by myself” is staged over and over again, and the film, just like at the close of the song, reverses it at the end (“don't wanna be all by myself anymore”). -
Agape Strong January/February 2016
Agape for Youth, Inc. Newsletter Agape Strong January/February 2016 2015………REFLECTING UPON AGAPE’S YEAR OF CELEBRATION!!! As I’ve written throughout the Agape youth and families reunification families from the Agape’s Strengths year, this has been, and continues participated at events including the BJKids91 Foundation, along with to be an amazing journey for Vectren Dayton Airshow, receiving over $400,000 in The combined top Agape! Columbus Zoo, Idle Hour Ranch, donated household items and five Strengths of the Dayton Dragons game, Young’s merchandise through our During 2015, we served over 160 staff at Agape are: Dairy, Laser Tag, and bowling made partnership with Good 360 was youth through our Foster Care possible through Agape’s Youth provided those we serve, and Developer program, had 19 of our youth and Family Fund built through the made available to other non- Empathy adopted by one of our many “Agape Strong” fundraiser bringing profits in our community. dedicated foster families, and had in a record breaking over $50,000, Responsibility more than 100 families (which and additional community Grants from the Reynolds and Belief included over 240 youth) be served donations. Reynolds Foundation, Vectren Positivity through our Reunification Services Foundation, PNC Foundation, program. Our belief that “the The youth we serve were provided and Hossie Martin Foundation, more we serve, the more with education incentives for their along with a significant ‘employee’ opportunities we will be given to success, tutoring services again outreach donation from serve” played out ten-fold. made possible through our CareSource (where they provided community support. -
In This Issue…
S P R I N G 2 0 0 9 V 1 7 I s s DIRECTIONS u e 8 FAMILIES OF SPINAL MUSCULAR ATROPHY In this Issue… (SMA news to shout about!) New SMA Care Booklets Breathing Basics – covering critical aspects of respiratory care for SMA. ............................................................3 Caring Choices - for parents of infants newly diagnosed with SMA Type I .....................................................13 25th Anniversary Conference See the full agenda for our annual family and professionals conference in Cincinnati, OH ...................................................4 25 Voices of SMA See the first profiles spotlighting families, clinicians and researchers from the SMA community ..................................6 Legislative News Updates on the SMA Treatment Acceleration Act and other topics from the new congress and administration ................8 “Ask the Expert” Service New system to submit important SMA care and health- related questions and search for answers online ................11 SMA Registry Online New website launched ...........................................................29 www.curesma.org DEAR families & friends www.curesma.org ur annual conference this year will be the perfect time for us to celebrate 25 years of FSMA and all that has been accomplished. O$50 Million raised and funded for SMA research over the last 25 years is an amazing achievement and has brought us incredibly far. However, this will not just be a year of looking back. We are a community that is in no way comfortably satisfied with where we currently stand. Families of We are a non-profit, 501(c)3 tax exempt SMA is aggressively increasing our funding commitments for research and organization. Funds will be specifically clinical programs to develop a treatment and cure. -
The Four Kinds of Love Activity Instructions
The Four Kinds of Love Activity Instructions Activity 1 Preparation: Cut up the texts on each of the four kinds of love Photocopy them onto different colour paper Set Up & Instructions Put the students in groups of 5 or 6 Tell the students their aim is to make notes on their table for each kind of love, using the information on the texts. Explain that the sub-box under each table category is for writing in examples of that kind of love. The students have 4 minutes per text, then shout “swap”: the students must put their text down and pick up another one. After 16 mins, give the students a few additional minutes to check their info with their partners, and complete anything missing. Feedback the answers. Activity 2 Summing Activity Explain how the love of a parent for their child can consist of all four kinds of love. Activity 3/ Plenary Nominate students from the class to choose a letter from the alphabet, name an adjective starting with that letter that would describe one kind of love. Encourage the students to explain their choice. Eg R - Romantic, C - caring Sacred Heart High School/mrumian 2009 The Four Kinds of Love Storge , or “affection” can be shown to people of objects. Towards people, storge is being fond of someone because we like and have got used to having them around. Eg a family member, or neighbour we have grown up with. Towards objects, storge is the loving satisfaction of having a good meal, or a fit and healthy body. -
When Tongzhi Marry: Experiments of Cooperative Marriage Between Lalas and Gay Men in Urban China
winner of the 2018 Feminist studies Graduate Student award Stephanie YingYi Wang When Tongzhi Marry: Experiments of Cooperative Marriage between Lalas and Gay Men in Urban China Ang Lee’s fiLm The Wedding BanqueT could be classic introductory material for tongzhi studies and, particularly, for research on cooper- ative marriage.1 In the film, Wai-Tung, a Taiwanese landlord who lives happily with his American boyfriend Simon in New York, is troubled by his parents’ constant efforts to try and find him a bride. His partner Simon suggests he could arrange a marriage of convenience with Wai- Tung’s tenant Wei Wei who is from mainland China and is also in need of a green card to stay in the United States. However, their plan back- fires when Wai-Tung’s enthusiastic parents arrive in the United States and plan a big wedding banquet. As the film critic and scholar Chris 1. Tongzhi, literally “same purpose,” is the Chinese term for “comrade.” Since the 1990s, it has been appropriated to replace the more formal tóngxìnglìan (same-sex love) to refer to gay men and lalas (same-sex desiring women) in the Chinese-speaking world. The translation of xinghun as “cooperative marriage” is debatable, as xinghun literally means “pro-forma marriage.” In other works, “contract marriage,” “fake marriage,” or “pro-forma marriage” are used to refer to gay-lala marriage. Informed by Lucetta Kam’s work, I use “cooperative mar- riage” to highlight that such marriage is not merely functional without sus- tenance, but is contingent on the cooperation and negotiation between mul- tiple parties in the relationship, as my findings suggest.