DOCSLIB.ORG

Modern Analytical Chemistry”

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Modern Analytical Chemistry” Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Hlavova 2030, 12843, Prague2, Czech Republic Prague 29. – 30. 1. 2007 Book of Proceedings Prague 2007 Published by the Czech Chemical Society ISBN 80 - 86238 - 96 - 2 We are very grateful to our sponsors for their kind support: http://www.zentiva.cz/ http://www.waters.com/ http://www.quinta.cz http://www.medicainfo.cz/jmr/jmr1604.htm Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Hlavova 2030, 12843, Prague2, Czech Republic 3rd International Student Conference “Modern Analytical Chemistry” Prague 29. – 30. 1. 2007 Book of Proceedings Prague 2007 Published by ISBN 80 - 86238 - 96 – 2 3 Vydala Česká společnost chemická. Za obsah veškerých textů nesou plnou zodpovědnost autoři. Publikace neprošla odbornou ani jazykovou úpravou a je určena pro účastníky semináře a členy pořádajících organizací. Není určena k volnému prodeji. Zveřejněné informace mohou být dále použity za předpokladu úplného citování původního zdroje. Přetiskování, kopírování či převádění této publikace do jakékoliv tištěné či elektronické formy a její prodej je možný pouze na základě písemného souhlasu vydavatele. (Bona fide vědečtí pracovníci si mohou pořídit jednotlivé xerox kopie). Published by the Czech Chemical Society in collaboration with organizers of the conference. This publication is made available for the conference participants, members of the organizing institutions and for documentary purposes. Some products named or cited in this publication and other materials of the congress are registered as trademarks or proprietary names even in the case this fact is being explicite shown or acknowledged. It is not to be considered as fail to notice the ownership or authorship by the publisher. All the texts are published with the full responsibility of authors for their content. The publication was not content or language-polished. Its content could be used on the condition of full acknowledgement and citation of the source. Direct reprinting, transformation to any means of electronic form is restricted (bona fide scientist may xerox single copies in accordance of their local copyright laws and regulations) and is possible upon written agreement with the publisher only. Vydala / Published By Novotného lávka 5, CZ 116 68, Praha 1 v roce 2007 1. vydání, brož., náklad 50 výtisků © Charles University in Prague ISBN 80 - 86238 - 96 – 2 4 An Invitation to the 3rd International Student Conference “Modern Analytical Chemistry” to be held on January 29 – 30, 2007 at the lecture hall CH5, Faculty of Science, Chemical Departments Building, Hlavova 2030, Prague 2 organized by Charles University in Prague, Faculty of Science Department of Analytical Chemistry and sponsored by 5 Monday January 29th Morning 9.00 M. Brauna, M. Adama, K. Štulíkb aInstitute of Rheumatology, Experimental Connective Tissue Research Laboratory Prague and bCharles University in Prague, Faculty of Science, Department of Analytical Chemistry High Performance Separation of Collagen and Elastin Cross-Links 9 9.30 M. Vadinskáa, Z. Bosákováa, E. Tesařováb Charles University in Prague, Faculty of Science, Departments of Analyticala and Physical and Macromolecularb Chemistry Study of Enantioseparation Behaviour of Profen Nsaids on the Teicoplanin Aglycone- Based Chiral Stationary Phase by HPLC. 17 10.00 L. Loukotkováa, Z. Bosákováa, E. Tesařováb Charles University in Prague, Faculty of Science, Departments of Analyticala and Physical and Macromolecularb Chemistry Study of the Influence of Experimental Conditions on the Retention and Enantioseparation of Series of Newly Synthesized Disubstituted Binaphthyls 28 10.30 H. Dejmková, J. Zima, J. Barek Charles University in Prague, Faculty of Science, Department of Analytical Chemistry HPLC-ED Determination of Aminonitrophenols 40 11.00 V. Šolínová, D. Koval, V. Kašička, M. Česnek, A. Holý Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague Determination of Acid-Base Dissociation Constants of Acyclic Nucleoside Phosphonates and Related Compounds by Capillary Zone Electrophoresis 49 11.30 J. Kratzera,b, J. Dědinaa, P. Rychlovskýb aAcademy of Sciences of the Czech Republic, Institute of Analytical Chemistry, Prague, Czech Republic and bCharles University in Prague, Faculty of Science, Department of Analytical Chemistry As and Se Hydride Trapping at the Quartz Surface - a Step Forward to In-situ Trapping in Quartz Tube Atomizers for AAS 59 Sponsored lunch 6 Monday January 29th Afternoon 13.30 Ž. Krkošováa, R. Kubineca, H. Jurdákováa, J. Blaškoa, B. Meľuchováa, I. Ostrovskýa, L. Sojáka, J. Ševčíkb, J. Višňovskýc aChemical Institute, Faculty of Natural Sciences, Comenius University, Bratislava bCharles University in Prague, Faculty of Science, Department of Analytical Chemistry, cCMS Chemicals, s. r. o., Nobelova 34, P. O. Box 44, SK-836 03 Bratislava Very Fast Gas Chromatography with a Ballistic Heating and Ultra Fast Cooling of the Column 68 14.00 B. Meľuchováa, V. Valkovskáa, H. Jurdákováa, Ž. Krkošováa, J. Blaškoa, P. Přikrylb, R. Kubineca, J. Ševčíkb, I. Ostrovskýa, L. Sojáka, V. Berezkinc aChemical Institute, Faculty of Natural Sciences, Comenius University, Bratislava bCharles University in Prague, Faculty of Science, Department of Analytical Chemistry, cA. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow Needle Concentrator and Solid Phase Micro-Extraction for Gas Chromatographic Determination of BTEX from Aqueous Samples 81 14.30 H. Jurdáková, L. Soják, R. Kubinec, Ž. Krkošová, J. Blaško, B. Meľuchová, E. Pavlíková Chemical Institute, Faculty of Natural Sciences, Comenius University, Bratislava GC Structure-Retention Relation and Mass Spectrometry for Identification of Polyalkenes Decomposing Products 94 15.00 J. Blaško, L. Soják, R. Kubinec, Ž. Krkošová, H. Jurdáková, B. Meľuchová, E. Pavlíková Chemical Institute, Faculty of Natural Sciences, Comenius University, Bratislava Analysis of Conjugated Linoleic Acid Isomers in Ewe Milk Products by GC-MS 107 15.30 O. Grossováa,b, J. Dědinaa a Academy of Sciences of the Czech Republic, Institute of Analytical Chemistry, Prague b Charles University, Faculty of Science, Prague, Czech Republic Development of L-Shaped Hydride Multiatomizer for Atomic Absorption Spectrometry 119 16.00 J. Musilováa, J. Bareka, K. Peckováa a Charles University in Prague, Faculty of Science, Department of Analytical Chemistry Use of Boron-Doped Diamond Electrode in Voltammetry of Biologically Active Organic Compounds 126 Social Meeting at the Department of Analytical Chemistry (from 17 o´clock) (Chemical Departments building) 7 Tuesday January 30th Morning 9.00 V. Vyskočila, J. Bareka, K. Čížeka, Z. Zawadab a Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague b Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Inorganic and Organic Chemistry, Hradec Králové Study of Electrochemical Behavior of 2,7-dinitro-9-fluorenone 132 9.30 A. Daňhel, J. Barek, B. Yosypchuk, K. Pecková Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Prague Voltammetric Determination of Genotoxic Nitrocompounds Using Silver Amalgam Electrodes 142 10.00 E. Svobodová, M. Vadinská, Z. Bosáková Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Prague Capillary Electrophoresis of Anthraquinone Dyes Employed in Works of Art 151 10.30 Z. Jemelková, J. Zima, J. Barek Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Prague HPLC - ED Determination of Epinephrine at Carbon Paste Electrode 160 11.00 R. Pospíchal, K. Nesměrák, P. Rychlovský Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Prague FIA Determination of Chondroitin Sulfate by Azure B with Spectrophotometric Detection 167 11.30 I. Jiráneka, J. Bareka, B. Yosypchukb, K. Peckováa, K. Čížeka a Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague b J.Heyerovský Institute of Physical Chemistry, Academy of Science of the Czech Republic, Prague Voltammetric Determination of Trace Amounts of Nitro and Amino Derivatives of Quinoline 177 Sponsored lunch 13.30 V. Červený, J. Hraníček, P. Rychlovský Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Prague Postcolumn Electrochemical Hydride Generation Used For Speciation Analysis of Arsenic Compounds 188 14.00 M. Hlína, M. Hrabovský, V. Kopecký, M. Konrad, T. Kavka, S. Skoblja Institute of Plasma Physics, ASCR, Prague and bDepartment of Gas, Coke and Air Protection, Institute of Chemical Technology, Prague Production of Gas with Low Content of Tar in Plasma Gasification Reactor 197 8 rd 3 International Student Conference: “Modern Analytical Chemistry“ HIGH PERFORMANCE SEPARATION OF COLLAGEN AND ELASTIN CROSS-LINKS a,b a b Martin Braun , Milan Adam and Karel Štulík a Institute of Rheumatology, Experimental Connective Tissue Research Laboratory Na Slupi 4, 128 50 Prague 2, Czech Republic; e-mail: [email protected] b Charles University, Faculty of Science, Department of Analytical Chemistry Albertov 8, 128 40 Prague 2, Czech Republic Abstract This work concerns the development and application of high performance separation methods suitable for determination of clinically considerable
Load more

Recommended publications
  • Modafinil and Modafinil Analogues: Free Radical Mechanism of the Eugeroic and Cognitive Enhancment Effect Clifford Fong
    Modafinil and modafinil analogues: free radical mechanism of the eugeroic and cognitive enhancment effect Clifford Fong To cite this version: Clifford Fong. Modafinil and modafinil analogues: free radical mechanism of the eugeroic and cognitive enhancment effect. [Research Report] Eigenenergy. 2018. hal-01933737 HAL Id: hal-01933737 https://hal.archives-ouvertes.fr/hal-01933737 Submitted on 24 Nov 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Modafinil and modafinil analogues: free radical mechanism of the eugeroic and cognitive enhancment effect Clifford W. Fong Eigenenergy, Adelaide, South Australia. Keywords: Modafinil, modafinil-like analogues, eugeroic effect, cognitive enhancement, free radicals, quantum mechanics Abbreviations Dopamine DA, dopamine transporter DAT, Dissociative electron transfer or attachment DET, Linear free energy relationship LFER, free energy of water desolvation ΔG desolv,CDS , lipophilicity free energy ΔG lipo,CDS, cavity dispersion solvent structure of the first solvation shell CDS, highest occupied molecular orbital HOMO, lowest unoccupied molecular orbital LUMO, multiple correlation coefficient R 2, the F test of significance, standards errors for the estimate (SEE) and standard errors of the variables SE(ΔG desolCDS ), SE(ΔG lipoCDS ), SE(Dipole Moment), SE (Molecular Volume), transition state TS, reactive oxygen species ROS.
    [Show full text]
  • Plant-Mediated Enantioselective Transformation of Indan-1-One and Indan-1-Ol. Part 2
    molecules Article Plant-Mediated Enantioselective Transformation of Indan-1-one and Indan-1-ol. Part 2 Wanda M ˛aczka 1,* , Katarzyna Wi ´nska 1,* , Małgorzata Grabarczyk 1,* and Renata Galek 2 1 Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland 2 Department of Genetics, Plant Breeding and Seed Production, Wroclaw University of Environmental and Life Sciences Pl. Grunwaldzki 24A, 53-363 Wroclaw, Poland; [email protected] * Correspondence: [email protected] (W.M.); [email protected] (K.W.); [email protected] (M.G.); Tel.: +48-71-320-5213 (W.M. & K.W.) Received: 31 October 2019; Accepted: 25 November 2019; Published: 27 November 2019 Abstract: The main purpose of this publication was to obtain the S-enantiomer of indan-1-ol with high enantiomeric excess and satisfactory yield. In our research, we used carrot callus cultures (Daucus carota L.), whereby the enzymatic system reduced indan-1-one and oxidized indan-1-ol. During the reaction of reduction, after five days, we received over 50% conversion, with the enantiomeric excess of the formed S-alcohol above 99%. In turn, during the oxidation of racemic indan-1-ol after 15 days, 36.7% of alcohol with an enantiomeric excess 57.4% S(+) remained in the reaction mixture. In addition, our research confirmed that the reactions of reduction and oxidation are competing reactions during the transformation of indan-1-ol and indan-1-one in carrot callus cultures. Keywords: indan-1-one; indan-1-ol; biotransformation; reduction; oxidation; carrot; callus culture 1.
    [Show full text]
  • 1St ANNUAL UNDERGRADUATE RESEARCH SYMPOSIUM
    Table of Contents Entree Subject Page 1 History of the Symposium 2 2 Program Schedule 4 3 Poster Abstract 28 4 Author/Faculty Information 132 5 Participating Institutions 137 1 HISTORY OF THE SYMPOSIUM Few activities are as rewarding as research to the motivated students as well as faculty mentors. In addition to the acquisition of invaluable research skills, students learn how knowledge is created and experience the excitement of the “eureka moment”. To celebrate undergraduate achievements, a research symposium has been held since 2007 on WPUNJ campus for students in biological and chemical sciences. In this event, undergraduate students present and display their research and creative work to the university and the scientific community from the Tri state area. This symposium provides an opportunity to the students to showcase their talents and share their research achievements with their peers from about twenty universities from Tri state area. The students and faculty from different universities as well as staff, and community members of WPU are invited to explore the latest in undergraduate research. Featured events include the poster presentation and Awards ceremony. The Symposium also features a keynote lecture by a distinguished researcher. 2 SYMPOSIUM ORGANIZING COMMITTEE Organizers Dr. Jaishri Menon Dr. Bhanu P. S. Chauhan Committee Members Dr. Jean Fuller-Stanley Dr. Michael Peek Dr. Eileen Gardner Dr. Jeung Woon Lee Dr. Carey Waldburger Dr. Pradeep Patnaik Dr. Mihaela Jitianu Dr. Mukesh Sahni Ms. Karyn Lapadura 3 SCHEDULE OF EVENTS 8:00 a.m. – 9:00 a.m. Registration & Breakfast Ballroom 9:00 a.m. – 9:15 am Welcome and Opening Remarks Dr.
    [Show full text]
  • Nootropics- Memory Boosters
    Harikumar K. et al. / Journal of Pharmaceutical Biology, 6(1), 2016, 14-19. Journal of Pharmaceutical Biology www.jpbjournal.com e-ISSN - 2249-7560 Print ISSN - 2249-7579 NOOTROPICS- MEMORY BOOSTERS K.Hari Kumar*, Mitta Srija, D.K.Sandeep, Ramisetty Davarika, Gunda Sai Mounica Department of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S.Nagar, Chittoor-517127, Andhra Pradesh, India. ABSTRACT Nootropics also called as smart drug, memory enhancers, neuron enhancers, cognitive enhancers and intelligent enhancers are drugs, supplements, neutraceuticals and functional foods that provide one or more aspects of mental function. Specific effect can include improvement to working memory motivation or attention. Nootropics drugs are able to promote, enhance and protect cognitive functions. As cognition is the typically human higher activity of brain, nootropic concept looked quite appealing for scores of people dreaming to enjoy better and longer lasting mental activity and for drug maker keen to produce such enviable products. There are large number of drugs which can be used as nootropic agents and help to enhance memory of people. Nootropics offer lot of benefits for cognitive aptitude and brain health. Nootropics used for the treatment of Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, dementia and cognitive symptoms of schizophrenia. Keywords: Nootropics, Huntington’s disease, Dementia, Alzheimer’s disease. INTRODUCTION It is derived from Greek words “NOOS –Mind” But non-ADHD medications and supplements are more “Tropein – Turn/Bend”. They are also called as memory frequently used for performance enhancement. Many enhancers, Smart nutrients, Cerebroactive drugs and individuals use these drugs for performance enhancement cognition enhancers.
    [Show full text]
  • New Psychoactive Substances (NPS)
    New Psychoactive Substances (NPS) LGC Quality Reference ISO 9001 ISO/IEC 17025 ISO Guide 34 materials GMP/GLP ISO 13485 2019 ISO/IEC 17043 Science for a safer world LGC offers the most extensive and up-to-date range of New LGC is a global leader in Psychoactive Substances (NPS) measurement standards, reference materials. reference materials, laboratory services and proficiency testing. With 2,600 professionals working When you make a decision using The challenge The LGC response We are the UK’s in 21 countries, our analytical our resources, you can be sure it’s designated National measurement and quality control based on precise, robust data. And New Psychoactive Substances In response to the ever-expanding LGC Standards provides the widest Measurement services are second-to-none. together, we’re creating fairer, safer, (NPS) continue to be identified, range of NPS being developed, LGC range of reference materials Institute for chemical more confident societies worldwide. and it appears that moves by the has produced a comprehensive available from any single supplier. and bioanalytical As a global leader, we provide the United Nations and by individual range of reference materials that We work closely with leading widest range of reference materials lgcstandards.com countries to control lists of meet the rapidly changing demands manufacturers to provide improved measurement. available from any single supplier. named NPS may be encouraging of the NPS landscape. Many of access to reference materials, the development of yet further these products are produced under with an increasingly large range variants to avoid these controls. the rigorous quality assurance of parameters, for laboratories standards set out in ISO Guide 34.
    [Show full text]
  • Drug/Substance Trade Name(S)
    A B C D E F G H I J K 1 Drug/Substance Trade Name(s) Drug Class Existing Penalty Class Special Notation T1:Doping/Endangerment Level T2: Mismanagement Level Comments Methylenedioxypyrovalerone is a stimulant of the cathinone class which acts as a 3,4-methylenedioxypyprovaleroneMDPV, “bath salts” norepinephrine-dopamine reuptake inhibitor. It was first developed in the 1960s by a team at 1 A Yes A A 2 Boehringer Ingelheim. No 3 Alfentanil Alfenta Narcotic used to control pain and keep patients asleep during surgery. 1 A Yes A No A Aminoxafen, Aminorex is a weight loss stimulant drug. It was withdrawn from the market after it was found Aminorex Aminoxaphen, Apiquel, to cause pulmonary hypertension. 1 A Yes A A 4 McN-742, Menocil No Amphetamine is a potent central nervous system stimulant that is used in the treatment of Amphetamine Speed, Upper 1 A Yes A A 5 attention deficit hyperactivity disorder, narcolepsy, and obesity. No Anileridine is a synthetic analgesic drug and is a member of the piperidine class of analgesic Anileridine Leritine 1 A Yes A A 6 agents developed by Merck & Co. in the 1950s. No Dopamine promoter used to treat loss of muscle movement control caused by Parkinson's Apomorphine Apokyn, Ixense 1 A Yes A A 7 disease. No Recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. It is often claimed that BZP was originally Benzylpiperazine BZP 1 A Yes A A synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals.
    [Show full text]
  • Lääkealan Turvallisuus- Ja Kehittämiskeskuksen Päätös
    LUONNOS 5.12.2018 Lääkealan turvallisuus- ja kehittämiskeskuksen päätös N:o xxxx lääkeluettelosta Annettu Helsingissä 15. päivänä maaliskuuta 2019 ————— Lääkealan turvallisuus- ja kehittämiskeskus on 10 päivänä huhtikuuta 1987 annetun lääke- lain (395/1987) 83 §:n nojalla päättänyt vahvistaa seuraavan lääkeluettelon: 1 § vallisten valmisteiden ja erityislupavalmis- Luettelon tarkoitus teiden vaikuttavia lääkeaineita. Liitteessä 1 on lueteltu ainoastaan lääkeai- Tämä päätös sisältää luettelon Suomessa neet. Lääkeaineiden suoloja ja estereitä ei ole lääkkeellisessä käytössä olevista aineista ja lueteltu. Lääkeaineet ovat valmisteessa suo- rohdoksista. Lääkeluettelo laaditaan ottaen lamuodossa teknisen käsiteltävyyden vuoksi. huomioon lääkelain 3 §:n ja 5 §:n säännök- Lääkeaine ja sen suolamuoto ovat biologises- set. ti samanarvoisia. Lääkkeellä tarkoitetaan valmistetta tai ai- Liitteen 1 A aineet ovat lääkeaineanalogeja netta, jonka tarkoituksena on sisäisesti tai ja prohormoneja. Kaikki liitteen 1 A aineet ulkoisesti käytettynä parantaa, lievittää tai rinnastetaan aina vaikutuksen perusteella ehkäistä sairautta tai sen oireita ihmisessä tai ainoastaan lääkemääräyksellä toimitettaviin eläimessä. Lääkkeeksi katsotaan myös sisäi- lääkkeisiin. sesti tai ulkoisesti käytettävä aine tai aineiden yhdistelmä, jota voidaan käyttää ihmisen tai 2 § eläimen elintoimintojen palauttamiseksi, Lääkkeitä ovat korjaamiseksi tai muuttamiseksi farmakolo- 1) tämän päätöksen liitteessä 1 luetellut ai- gisen, immunologisen tai metabolisen vaiku- neet, niiden suolat
    [Show full text]
  • UCLA Electronic Theses and Dissertations
    UCLA UCLA Electronic Theses and Dissertations Title Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes Permalink https://escholarship.org/uc/item/1zh4c0s7 Author Allison, Nathanael Publication Date 2018 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA Los Angeles Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Biomedical Physics by Nathanael Allison 2018 © Copyright by Nathanael Allison 2018 ABSTRACT OF THE DISSERTATION Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes by Nathanael Allison Doctor of Philosophy in Biomedical Physics University of California, Los Angeles, 2018 Professor Seyed Sam Sadeghi Hosseini, Chair Abstract: Thioether and aromatic molecules were electrochemically radiolabeled with [18F]Fluoride under carrier-added and no-carrier-added conditions. The addition of excess carrier fluoride (i.e. stable isotope fluoride) in traditional electrochemical fluorination leads to low fluorination yields, which cause low radiochemical yields and molar activity when using [18F]Fluoride. Electrochemical syntheses were extensively investigated herein and optimized to remove the need for the addition of excess carrier fluoride, increasing radiochemical yield and molar activity rendering this electrochemical methodology suitable for the potential use in Positron Emission Tomography radiotracer synthesis. The electrochemical fluorination mechanisms of ECEC, where E is an electrochemical process and C is a chemical reaction, and fluoro- Pummerer rearrangement were explored with the transition to no-carrier-added conditions.
    [Show full text]
  • Substance Abuse in the Workplaces of Our Bodies and Mind
    “Turn on, Tune in, Drop out “ Substance Abuse in the Workplaces of our bodies and mind.. Warren Silverman MD Brief History of Drug abuse – Mary Jane 1629 – Marijuana introduced to the Puritan colonies of New England 1765 – George Washington was cultivating Marijuana for a sore tooth 1800’s Tincture of Cannabis is available from pharmacies, unpopular due to variations in potency and dosage, but recreational use continues with Hashish clubs in most cities by 1885 By the 20th century, marijuana use was associated with racial groups and drug abusers and lost popularity The foreign origin of marijuana lead to propaganda against its use (as we have just seen), by 1930’s marijuana was considered wicked In the 1960’s, drug use was considered a demonstration of anti-establishment leanings and became popular Marijuana has remained a constant presence in our society with gradual legislation to decriminalize and legitimize its use Brief History of Drug Abuse - Opiates In colonial America, Opiate medications were common in London and imported to the colonies – used to treat pain from diarrhea, colds, fever, tooth aches, cholera, rheumatism, pelvic disorders, athlete’s foot and baldness 1784 Dr. William Buchan’s book tells people how to make their own tincture of Opium (paregoric) to keep around the house 1804 catalogue listed 90 brands of elixir, by 1905 it was more than 28,000 1803 Morphine developed (Morpheus – god of dreams) Hypodermic needle invented and by the civil war Morphine was widely used as injectable 1898 Heroin developed
    [Show full text]
  • Investigations on 2,7-Diamino-9-Fluorenol Photochemistry
    Investigations on 2,7-diamino-9-fluorenol photochemistry INAUGURALDISSERTATION zur Erlangung der Würde eines Doktors der Philosophie vorgelegt der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel von DRAGANA ZIVKOVIC aus Pirot, Serbien Basel, 2007 Genehmigt von der Philosophisch-Naturwissenschaftlichen Fakultät auf Antrag von Prof. Dr. J. Wirz und Prof. Dr. H. Huber. Basel, den 24. 04. 2007. Prof. Dr. Hans Peter Hauri Dekan Dedicated to my family and to Ian Acknowledgments First of all, I would like to thank Prof. Dr. Jakob Wirz for giving me the opportunity to join his research group, for guiding and supporting my work. I thank Prof. Dr. Hanspeter Huber for agreeing to act as co-referee. I thank Prof. Dr. Martin Jungen for agreeing to act as chairman of the thesis committee. A special thanks to the members of the Wirz group: Hassen Boudebous, Martin Gaplovsky, Yavor Kamdzhilov, Gaby Persy, Bruno Hellrung, Jürgen Wintner, Pavel Müller and Dominik Heger. Thanks for making the atmosphere in the lab so enjoyable, for the useful discussions and for always being ready to help. I thank my family and friends, especially Mat and Janni, for their affection and constant encouragement. I thank piggy, for being there for me, and for cheering me up when experiments didn’t work. Finally, I would also like to thank the Swiss National Science Foundation and the University of Basel for their financial support. Table of Contents 1. Introduction.................................................................................................................1 1.1. Major photoremovable protecting groups........................................................... 3 1.1.1. The 2-nitrobenzyl group ............................................................................. 3 1.1.2. The benzoin group ...................................................................................... 5 1.1.3.
    [Show full text]
  • Inhibition of the Dopamine Monoamine Transporter DAT by Modafinil Like
    CORE Metadata, citation and similar papers at core.ac.uk Provided by Archive Ouverte en Sciences de l'Information et de la Communication Modafinil mechanism of action: Inhibition of the dopamine monoamine transporter DAT by modafinil like and piperidine-based analogues and the role of free radicals in the eugeroic effect Clifford Fong To cite this version: Clifford Fong. Modafinil mechanism of action: Inhibition of the dopamine monoamine transporter DAT by modafinil like and piperidine-based analogues and the role of free radicals in the eugeroic effect. [Research Report] Eigenenergy, Adelaide, Australia. 2018. hal-01693225v2 HAL Id: hal-01693225 https://hal.archives-ouvertes.fr/hal-01693225v2 Submitted on 15 Apr 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Modafinil mechanism of action: Inhibition of the dopamine monoamine transporter DAT by modafinil like and piperidine-based analogues and the role of free radicals in the eugeroic effect Clifford W. Fong Eigenenergy, Adelaide, South Australia. Keywords: Modafinil analogues, eugeroic effect,
    [Show full text]
  • III IIII US005506359A United States Patent 19 11 Patent Number: 5,506,359 Madras Et Al
    III IIII US005506359A United States Patent 19 11 Patent Number: 5,506,359 Madras et al. 45) Date of Patent: Apr. 9, 1996 (54) COCAINE ANALOGUES AND THEIR USE AS ne-Releasing Effects of H-3-CFT (WIN35,428): A Poten COCANE DRUG THERAPES AND tial Brain Imaging Ligand for Dopamine Transporter or THERAPEUTIC AND MAGNGAGENTS Cocaine . " Soc. Neuro. Abs., 16:309.5 (1990). FOR NEURODEGENERATIVE DISORDERS Clarke et al. "(2-exo-3-endo)-2-Aryltropane-3-carboxylic Esters, a (75) Inventors: Bertha K. Madras, Newton; Peter New Class of Narcotic Antagonists' J. Med. Chem, Meltzer, Lexington, both of Mass. 21:1235-1242 (1978). Clarke et al. "Compounds Affecting the Central Nervous 73) Assignee: President and Fellows of Harvard System. 4.3B-Phenyltropane-2-carboxylic Esters and Ana College, Cambridge, Mass. logs' J. Med. Chem., 16:1260-1267 (1973). Cline et al. "Behavior Effects of Novel Cocaine Analogs: A 21 Appl. No.: 111,141 Comparison with in Vivo Receptor Binding Potency' J. Pharm. & Exp. Therapeutics, 260:1174-1179 (1992). 22 Filed: Aug. 24, 1993 Daum et al. "Compounds Affecting the Central Nervous System. 3. 3?-Phenyltropan-2-ols' J. Med. Chem., Related U.S. Application Data 16:667-670 (1973). 63 Continuation-in-part of Ser. No. 934,362, Aug. 24, 1992, Elmaleh et al. “N-C-11 abandoned. -Methyl-2B-Carbomethoxy-3B-Phenyl Tropane C-11) PT) and Glucose Utilization in a Primate Model of Hun (51) Int. Cl. ...................................... CO7) 451/02 tington's Disease” J. Nuclear Med. Abs., 32:552 (1991). 52 U.S. Cl. ................. 546/130; 54.6/128; 54.6/129 Elmaleh et al.
    [Show full text]