Anti-MAGI3 (Aa 716-979) Polyclonal Antibody (DPABH-10219) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use
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Anti-MAGI3 (aa 716-979) polyclonal antibody (DPABH-10219) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Immunogen Recombinant fragment, corresponding to amino acids 716-979 of Human MAGI3 (BC130409). Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, IHC-P Format Liquid Size 100 μg Buffer pH: 7.20; Constituent: 99% PBS Preservative 0.02% Sodium Azide Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. GENE INFORMATION Gene Name MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [ Homo sapiens ] 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Official Symbol MAGI3 Synonyms MAGI3; membrane associated guanylate kinase, WW and PDZ domain containing 3; membrane- associated guanylate kinase, WW and PDZ domain-containing protein 3; MAGI 3; membrane- associated guanylate kinase-related 3; membrane-associated guanylate kinase inverted 3; MAGI-3; dJ730K3.2; RP4-730K3.1; MGC163281; Entrez Gene ID 260425 Protein Refseq NP_001136254 UniProt ID Q5TCQ9 Chromosome Location 1p12-p11.2 Pathway Tight junction; Wnt Signaling Pathway NetPath; Function ATP binding; guanylate kinase activity; nucleotide binding; protein binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.