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The Avon Longitudinal Study of Parents and Children - a Resource for COVID-19 Research: Questionnaire Data Capture Wellcome Open Research 2020, 5:127 Last updated: 09 JUL 2021 DATA NOTE The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020 [version 2; peer review: 2 approved] Kate Northstone 1, Simown Howarth 2, Daniel Smith 1, Claire Bowring 1, Nicholas Wells 1, Nicholas John Timpson 1,3 1Population Health Science, Bristol Medical SChool, University of Bristol, Bristol, BS8 2BN, UK 2Bristol Dental School, University of Bristol, Bristol, BS1 2LY, UK 3MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, Bristol, BS8 2BN, UK v2 First published: 10 Jun 2020, 5:127 Open Peer Review https://doi.org/10.12688/wellcomeopenres.16020.1 Latest published: 20 Nov 2020, 5:127 https://doi.org/10.12688/wellcomeopenres.16020.2 Reviewer Status Invited Reviewers Abstract The Avon Longitudinal Study of Parents and Children (ALSPAC) is a 1 2 prospective population-based cohort study which recruited pregnant women in 1990-1992. The resource provides an informative and version 2 efficient setting for collecting data on the current coronavirus 2019 (revision) report report (COVID-19) pandemic. In early March 2020, a questionnaire was 20 Nov 2020 developed in collaboration with other longitudinal population studies to ensure cross-cohort comparability. It targeted retrospective and version 1 current COVID-19 infection information (exposure assessment, 10 Jun 2020 report symptom tracking and reported clinical outcomes) and the impact of both disease and mitigating measures implemented to manage the COVID-19 crisis more broadly. Data were collected on symptoms of 1. Sarah Crozier , University of COVID-19 and seasonal flu, travel prior to the pandemic, mental Southampton, Southampton, UK health and social, behavioural and lifestyle factors. Janis Baird, University of Southampton, The online questionnaire was deployed across parent (G0) and offspring (G1) generations between 9th April and 15th May 2020. 6807 Southampton, UK participants completed the questionnaire (2706 original mothers, 1014 original fathers/partners, 2973 offspring (mean age ~28 years) 2. Anteo Di Napoli , National Institute for and 114 offspring partners). Eight (0.01%) participants (4 G0 and 4 G1) Health Migration and Poverty (INMP), Rome, reported a positive test for COVID-19, 77 (1.13%; 28 G0 and 49 G1) Italy reported that they had been told by a doctor they likely had COVID-19 and 865 (12.7%; 426 G0 and 439 G1) suspected that they have had Martina Ventura, National Institute for COVID-19. Using algorithmically defined cases, we estimate that the Health Migration and Poverty (INMP), Rome, predicted proportion of COVID-19 cases ranged from 1.03% - 4.19% Italy depending on timing during the period of reporting (October 2019- March 2020). Any reports and responses or comments on the article can be found at the end of the article. Data from this first questionnaire will be complemented with at least two more follow-up questionnaires, linkage to health records and Page 1 of 15 Wellcome Open Research 2020, 5:127 Last updated: 09 JUL 2021 results of biological testing as they become available. Data has been released as: 1) a standard dataset containing all participant responses with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. Keywords ALSPAC, Children of the 90s, birth cohort study, COVID-19, coronavirus, online questionnaire, mental health This article is included in the Avon Longitudinal Study of Parents and Children (ALSPAC) gateway. This article is included in the Coronavirus (COVID-19) collection. Corresponding author: Kate Northstone ([email protected]) Author roles: Northstone K: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Methodology, Project Administration, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing; Howarth S: Investigation, Methodology, Writing – Review & Editing; Smith D: Data Curation, Formal Analysis, Writing – Review & Editing; Bowring C: Methodology, Project Administration, Supervision, Writing – Review & Editing; Wells N: Methodology, Project Administration, Software, Writing – Review & Editing; Timpson NJ: Conceptualization, Funding Acquisition, Investigation, Supervision, Writing – Review & Editing Competing interests: No competing interests were disclosed. Grant information: The work was supported by the Wellcome Trust through core support to ALSPAC [102215]. The UK Medical Research Council, the Wellcome Trust and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Kate Northstone will serve as guarantor for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). This work was also supported by the Elizabeth Blackwell Institute for Health Research, University of Bristol. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2020 Northstone K et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite this article: Northstone K, Howarth S, Smith D et al. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020 [version 2; peer review: 2 approved] Wellcome Open Research 2020, 5:127 https://doi.org/10.12688/wellcomeopenres.16020.2 First published: 10 Jun 2020, 5:127 https://doi.org/10.12688/wellcomeopenres.16020.1 Page 2 of 15 Wellcome Open Research 2020, 5:127 Last updated: 09 JUL 2021 The wider COVID-19 data collection in ALSPAC will REVISED Amendments from Version 1 include data from three main sources: self-reported data from questionnaires, data from clinical services based on linkage The second version of our manuscript takes into account the constructive comments made by the reviewers. In particular, to medical and other records and though biological samples. we have provided detail in the introduction explaining what the The data from these sources are intended to be complementary UK lockdown entailed and we have emphasised the issues with and help address different potential research questions around applying the Menni algorithm to symptom data collected in 2019 COVID-19. This data note describes the data collected via our in both the results and discussion. first online questionnaire between th9 April and 14th May 2020 Any further responses from the reviewers can be found at and provides a summary of the participants who responded. the end of the article Updates on subsequent questionnaires and other sources of data will be released as these additional datasets are made available. Introduction Methods The coronavirus disease 2019 (COVID-19) pandemic is a Setting rapidly developing global health challenge. There is marked ALSPAC is an intergenerational longitudinal cohort that heterogeneity in disease prevalence, severity and outcome recruited pregnant women residing in Avon, UK with expected both within and across populations. In part, this may be driven dates of delivery 1st April 1991 to 31st December 19922,3. by the interplay between environmental, social and host factors The initial cohort consisted of 14,541 pregnancies result- such as age and pre-existing comorbidities which predispose ing in 14,062 live births and 13,988 children who were alive at or protect against infection or modify disease outcomes. 1 year of age. From the age of seven onwards, the initial sam- Understanding this interplay requires studies with detailed ple was bolstered with eligible cases who had originally failed environmental, health, lifestyle, and biological data – ideally to join the study and there were subsequently 14,701 children measured within the context of longitudinal data and with alive at 1 year of age following this further recruitment4. Please prospective collection opportunities. note, the study website contains details of all the data that is available through a fully searchable data dictionary and variable Alongside the health implications of the virus itself, the search tool. response to the pandemic is likely to affect health and wellbe- ing. Mitigation measures have resulted in far-reaching changes In response to the COVID-19 it was necessary to develop a to daily activity which are likely to have an impact on nearly all data collection strategy which was practical, would yield data aspects of work, family life, recreation and, potentially, health. quickly and could be updated and repeated. For these rea- The nationwide ‘lockdown’ strategy implemented on 23rd March sons, we chose to use an online only data collection approach 2020, for example, meant that UK residents were only allowed for this, restricting our invites to those participants with a valid to leave the house to: 1) buy basic necessities, 2) exercise once email address (and coordinated with a systematic communica- a day, 3) attend to a medical need or care for a vulnerable per- tions/outreach campaign). The questionnaire was developed son 4) travel to and from work that could not be done at home1. and deployed using REDCap (Research
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