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Alimentary Alliesthesia and Sensory-Specific Satiety Michael Romer

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Alimentary Alliesthesia and Sensory-Specific Satiety Michael Romer Hedonic sensations implicated in the control of human food intake : alimentary alliesthesia and sensory-specific satiety Michael Romer To cite this version: Michael Romer. Hedonic sensations implicated in the control of human food intake : alimentary alliesthesia and sensory-specific satiety. Agricultural sciences. Université de Bourgogne, 2011. English. NNT : 2011DIJOS081. tel-00728852 HAL Id: tel-00728852 https://tel.archives-ouvertes.fr/tel-00728852 Submitted on 6 Sep 2012 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. UNIVERSITÉ DE BOURGOGNE UFR 910 SCIENCE VIE TERRE ENVIRONNEMENT École doctorale E2S Dijon THÈSE Pour obtenir le grade de Docteur de l’Université de Bourgogne Discipline : Sciences Vie par Michael A. ROMER le 10 mai 2011 Sensations hédoniques impliquées dans le contrôle de la prise alimentaire chez l’homme : Alliesthésie alimentaire et Rassasiement sensoriel spécifique Hedonic sensations implicated in the control of human food intake: Alimentary alliesthesia and sensoryspecific satiety Directeur de thèse Luc Pénicaud Coencadrant Laurent Brondel Jury Pr Marc Fantino ............. président Pr Michel Cabanac ......... rapporteur Pr Kees de Graaf ............ rapporteur Dr Luc Pénicaud ............. examinateur Pr Michel Narce .............. examinateur Dr Didier Chapelot ......... examinateur Dr Patrick Pasquet ......... examinateur Dr Laurent Brondel ....... examinateur 1 Remerciements CESG Concernant l’encadrement de ma thèse, mon apprentissage scientifique et statistique, je voudrais d’abord remercier les membres du Centre Européen des Sciences du Goût (CESG) avec lesquels j’ai pu collaborer au cours des années. Mes remerciements s’adressent tout d’abord au Dr Laurent Brondel qui m’a enseigné la démarche scientifique mais aussi l’analyse critique des études publiées et la mise en cause des idées préconçues ce qui est essentiel pour avancer dans la Science. Il m’a enseigné également les analyses statistiques appliquées et la rédaction d’article. Des remerciements s’adressent également au Dr Tao Jiang avec qui j’ai partagé de nombreuses heures de réflexion sur la prise alimentaire et qui m’a fait partager son savoir en statistiques. Un grand merci au Dr Fabienne Liennard, qui m’a toujours accordé son temps et m’a fait profiter de son expérience avec les animaux de laboratoire. Grace à elle j’ai pu conduire à bien mes expériences sur les rongeurs en 2008. Je remercie aussi le Dr Luc Pénicaud, directeur du Centre des Sciences du Goût et de l’Alimentation (CSGA), pour m’avoir fait l’honneur d’être mon directeur de thèse. Je n’oublie pas non plus le Pr André Holley, le Dr Ingrid Jakob, le Pr Daniel Rigaud et le Dr Benoist Schaal pour leurs conseils et leurs enseignements. Jury de thèse Je voudrais remercier aussi les membres du jury d’avoir accepté de participer à la révision critique de ma thèse et à ma soutenance. Mes remerciements s’adressent d’abord au Dr Patrick Pasquet pour m’avoir accueilli dans son bureau au Musée de l’Homme de Paris où j’ai pu présenter mes expériences sur les rats. Mes remerciements s’adressent ensuite au Dr Didier Chapelot pour nos échanges toujours très riches et très intéressants et son amabilité lors de mon passage dans son laboratoire à l’université Bobigny Paris XIII. Je suis aussi très reconnaissant au Pr Kees de Graaf d’avoir accepté de faire partie de mon jury de thèse et pour ce faire, d’avoir accepté de se rendre à Dijon depuis les Paysbas. Les études qu’il a menées jusqu’alors ont élargi mes connaissances en recherche. Je suis très honoré de la présence du Pr Michel Cabanac à ma soutenance et de la gentillesse qu’il a de se déplacer pour cela depuis le Québec. Il a inspiré mon travail de recherche. Je le remercie aussi de ses conseils critiques. 2 Mes remerciements s’adressent enfin au Pr Marc Fantino pour avoir accepté la présidence de mon comité de thèse et pour tous ses écrits qui m’ont toujours été très profitables. Famille À mes parents HansAlbert Anton et Rosemarie, À mes sœurs Ariane Patrizia Alexandra Konstanze et Selina Alexandra, À ma nièce Aline Jessika Rebekka, À ma grandmère trépassée Bettina « Betty » né Brauneis qui m’a enseigné la nature, À mon grandpère trépassé Karl, À ma grandmère trépassée Maria « Aja », À mon grandpère trépassé Josef, À mon oncle Hartmuth, À mon cousin Holger « Hulkir » Renz, À mes cousines Gabi et Claudia, À mon grandoncle Rudolf Ludwig Mössbauer qui m’a appris que la persévérance est la base de succès, À ma compagne, Flor de María Erari, qui m’a assisté et m’a soutenu énormément ces derniers mois, À ses parents María Dolores et José Luis, À Regina, Amis et Amies À ceux avec qui j’ai pu partager une partie du chemin, et qui m’ont permis d’être ce que je suis devenu ... Martin Bräuer, Fritz « Bumsti » Mark, Fritz « Boss » Mark, Alexander Wolffhardt, Georg Kutschera, Werner Skvara, Andreas Weinzinger, Alexander Hajos, Jameson « Kris » Dapin, Hannah Pabinguit, Silvère Beltrando, Alexander Wilhelm, Benedikt Dommes, Dominik Chlubna, Nicolas Blin Elisabeth KinskyEttl, Benoit Vandangeon, Jingle Dapin, Myrna C. Magpantay, Khazandra « Zan » Dapin, Somporn « Mae » Saokrachok ( ), Nathalie Pressia, Antonia Lombard du Plessis, Mészáros 3 „Alle Wahrheit durchläuft drei Stufen. Zuerst wird sie lächerlich gemacht oder verzerrt. Dann wird sie bekämpft. Und schließlich wird sie als selbstverständlich angenommen.“ unbekannter Author (Arthur Schopenhauer zugeschrieben) “All truth passes through three stages: First it is ridiculed or distorted. Then it is violently opposed. And finally it is accepted as being selfevident.” unknown author (attributed to Arthur Schopenhauer) 4 TABLE OF CONTENTS I. ABSTRACTS ............................................................................................................................................. 9 I.1. Summary ............................................................................................................................................................................ 9 I.1.1. Keywords ......................................................................................................................................................................... 10 I.2. Résumé ............................................................................................................................................................................. 10 I.2.1. Motsclés .......................................................................................................................................................................... 11 II. PHYSIOLOGIC CONTROL OF FOOD INTAKE BEHAVIOR ...................................................................... 12 II.1. Introduction ...................................................................................................................................................................... 12 II.2. ‘Regulation’ or ‘Control’ of food intake? ......................................................................................................................... 12 II.2.1. Regulation ........................................................................................................................................................................ 12 II.2.2. Control .............................................................................................................................................................................. 13 II.2.3. Regulation versus Control ................................................................................................................................................ 13 II.3. Energy homeostasis .......................................................................................................................................................... 14 II.4. CNS Centers of food intake control .................................................................................................................................. 14 II.4.1. The hypothalamus ............................................................................................................................................................ 14 II.4.2. Extrahypothalamic regions .............................................................................................................................................. 19 II.5. Peripheral regulation signals ............................................................................................................................................ 19 II.5.1. Short and longterm signals .............................................................................................................................................. 19 II.5.2. Digestive signals............................................................................................................................................................... 19 II.5.3. Hormonal signals .............................................................................................................................................................. 21 II.6. Food
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