Review Article Progress on Research and Development of Paederia Scandens As a Natural Medicine
Int J Clin Exp Med 2019;12(1):158-167 www.ijcem.com /ISSN:1940-5901/IJCEM0076353 Review Article Progress on research and development of Paederia scandens as a natural medicine Man Xiao1*, Li Ying2*, Shuang Li1, Xiaopeng Fu3, Guankui Du1 1Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, P. R. China; 2Haikou Cus- toms District P. R. China, Haikou, P. R. China; 3Clinical College of Hainan Medical University, Haikou, P. R. China. *Equal contributors. Received March 19, 2018; Accepted October 8, 2018; Epub January 15, 2019; Published January 30, 2019 Abstract: Paederia scandens (Lour.) (P. scandens) has been used in folk medicines as an important crude drug. It has mainly been used for treatment of toothaches, chest pain, piles, hemorrhoids, and emesis. It has also been used as a diuretic. Research has shown that P. scandens delivers anti-nociceptive, anti-inflammatory, and anti- tumor activity. Phytochemical screening has revealed the presence of iridoid glucosides, volatile oils, flavonoids, glucosides, and other metabolites. This review provides a comprehensive report on traditional medicinal uses, chemical constituents, and pharmacological profiles ofP. scandens as a natural medicine. Keywords: P. scandens, phytochemistry, pharmacology Introduction plants [5]. In China, for thousands of years, P. scandens has been widely used to treat tooth- Paederia scandens (Lour.) (P. scandens) is a aches, chest pain, piles, hemorrhoids, and perennial herb belonging to the Paederia L. emesis, in addition to being used as a diuretic. genus of Rubiaceae. It is popularly known as Research has shown that P. scandens has anti- “JiShiTeng” due to the strong and sulfurous bacterial effects [6].
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