Download Part 1

Total Page:16

File Type:pdf, Size:1020Kb

Download Part 1 1 This lab activity is aligned with Visible Body’s Human Anatomy Atlas app. Learn more at visiblebody.com/professors We've split our Cranial Nerves lab activity into two parts. Part 1 is pre-lab exercises as well as exercises that incorporate cranial nerves I-VI. Part 2 includes exercises covering cranial nerves VII-XII as well as post-lab exercises. 2 PRE-LAB EXERCISES A. In the main menu at the top of the screen, use the Views tab to search by body systems. Under Nervous System Views, select 2. Brain, and make the following observations: 1. Which two structures make up the central nervous system (CNS)? 2. This view demonstrates the location of bones that form the cranium. What important roles does the cranium play in regard to the brain? 3. Identify each of the bones that form the cranium. Hide each of these bones after you’ve identified them: a. Frontal b. Parietal (left) c. Occipital d. Temporal (left and right) e. Sphenoid f. Zygomatic (left and right) g. Ethmoid 4. Rotate the image so that you are viewing the lateral surface of the left cerebral hemisphere. Select and identify each of the following regions of the brain: a. Frontal lobe of the cerebrum b. Precentral gyrus of the frontal cortex c. Postcentral gyrus of the parietal lobe d. Parietal lobe of the cerebrum e. Temporal lobe of the cerebrum f. Occipital lobe of the cerebrum g. Cerebellum h. Midbrain 3 i. Cerebral crus of the midbrain j. Superior colliculus of the midbrain k. Inferior colliculus of the midbrain l. Pons m. Medulla oblongata 5. While it is not visible from this view, what part of the nervous system would extend below the medulla oblongata? 6. Select any of the cranial nerves in this view. Then, in the content box, select the caret at the top left. The caret will open a breadcrumb trail with a hierarchy of structures. In this hierarchy, select "Cranial nerves" and use the definition to answer the following questions: a. How many pairs of cranial nerves are there in the human body? b. Cranial nerves are named for their connection to which part of the central nervous system? c. How many pairs of spinal nerves are there in the human body? B. In preparation for more extensive learning in lab, use Nervous System View 6. Cranial Nerves to identify the 12 pairs of cranial nerves. Be sure to use the Systems menu on the left side of the screen to deselect the skeletal, muscular, and digestive systems for the best view of the nerves. Use the space below to write out the scientific name of each nerve and a brief description of its location. 1. Cranial nerve 01 (I) – 2. Cranial nerve 02 (II) – 3. Cranial nerve 03 (III) – 4. Cranial nerve 04 (IV) – 5. Cranial nerve 05 (V) – 6. Cranial nerve 06 (VI) – 4 7. Cranial nerve 07 (VII) – 8. Cranial nerve 08 (VIII) – 9. Cranial nerve 09 (XI) – 10. Cranial nerve 10 (X) – 11. Cranial nerve 11 (XI) – 12. Cranial nerve 12 (XII) – 5 IN-LAB EXERCISES: Obtain a brain model or a preserved specimen. Use the following modules to guide your exploration of the brain and the cranial nerves. As you identify structures, use the book icon to access definitions so you can answer the questions below. You are responsible for the identification of all bolded terms. 1. Brain Frontal bone Parietal bone Ethmoid bone Occipital bone Sphenoid bone Zygomatic bone Temporal bone 6 2. Brain Postcentral gyrus of parietal lobe Precentral gyrus of frontal cortex Parietal lobe Frontal lobe Occipital lobe Midbrain Pons Cerebellum Medulla oblongata 7 3. Brain Cerebrum Diencephalon Midbrain Cerebellum Pons Medulla oblongata A. Begin by reviewing locations of major brain regions. Return to Nervous System Views and select 2. Brain, to help you identify the following structures on your specimen: 1. Cerebrum 2. Cerebellum 3. Diencephalon 4. Midbrain 5. Pons 6. Medulla oblongata 8 Cranial Nerves CN 01 (I) Olfactory CN 02 (II) Optic CN 03 (III) Oculomotor CN 04 (IV) Trochlear CN 06 (VI) Abducens CN 05 (V) Trigeminal CN 07 (VII) Facial CN 09 (IX) Glossopharyngeal CN 08 (VIII) Vestibulocochlear CN 10 (X) Vagus CN 12 (XII) Hypoglossal CN 11 (XI) Spinal (Accessory) 9 B. Identification of the Olfactory Nerves (I) Olfactory Nerves (I) Medial stria of CN 01 Lateral stria of CN 01 Olfactory bulbs Olfactory tracts 1. In Nervous System Views, select 6. Cranial Nerves. Hide the sphenoid, frontal, and temporal bones to best see the required structures. Select any part of the olfactory nerve and answer the following questions: a. These nerves are sensory/motor/mixed (circle one). b. These nerves are responsible for the sense of ________________________. c. Where do these nerves originate? 2. Using this same view, identify the following structures and answer questions based on their descriptions. a. Cribriform plate of the ethmoid bone i. Fade the cribriform plate and observe its relationship with the olfactory nerves. 10 ii. The cribriform plate supports the ________________________ - the terminus of the ______________________________ - and is perforated by numerous ________________________ for the passage of the branches of the _____________________________. b. Olfactory bulbs of CN 01 i. Are olfactory bulbs seated superior or inferior to the cribriform plate? ii. Zoom in to see the projections on the inferior surface of the bulbs. (Tip: You may need to hide the ethmoid bone to see them well.) iii. Within each bulb, axons of olfactory _________ form synapses with dendrites and cell bodies of other ________________________. iv. If you are attempting to view the olfactory bulbs on a preserved specimen, they may be missing or incomplete. Why do you think this is? c. Olfactory tracts of CN 01 - Olfactory tracts are formed by axons/dendrites (circle one). d. Lateral stria of CN 01 - Follow this tract to see which region of the brain it terminates in: e. Medial stria of CN 01 - Follow this tract to see which region of the brain it terminates in: f. Signals transmitted along the olfactory tracts terminate in the ________________________________ area in the ___________________ lobe of the cerebral cortex. 3. Based on your learning, how do you think damage to this nerve would present clinically? 4. What types of tests would you devise to test the function of this nerve in patients? 11 C. Identification of the Optic Nerves Optic Nerves (II) Optic chiasm Hypothalamus Pituitary gland CN 02 (II) Optic 12 1. In Nervous System Views, select 6. Cranial Nerves. Rotate the image so you are looking into the empty socket of the right eye. Select the optic nerve and then select Fade Others. Observe its location and read the description. a. These nerves are sensory/motor/mixed (circle one). b. These nerves are responsible for the sense of _________________. c. They originate in the ______________________ of each eye. d. Which bone contains the optic foramina that the optic nerves pass through (be sure to identify this structure)? e. At which point do the right and left optic nerves converge? f. Where do the optic tracts exist? 2. Rotate the image so you are looking into the right cerebral hemisphere. Select the optic chiasm and read the description. a. The optic chiasm is the crossing point of the optic nerves. Is it a partial or a complete crossing? b. The crossed fibers occupy the medial/lateral (circle one) part of the chiasm. c. The uncrossed fibers occupy the medial/lateral (circle one) part of the chiasm. d. Where is the optic chiasm located in relation to the pituitary gland? 13 e. Where is the optic chiasm located in relation to the hypothalamus? f. Posterior to the optic chiasm, fibers from the optic nerves travel in the form of optic _________ to the _____________. g. Based on the anatomy of the optic chiasm, do you think the right cerebral hemisphere will process vision from the right eye, left eye, or both eyes? 3. Based on your learning, how do you think damage to this nerve would present clinically? 4. What types of tests would you devise to test the function of this nerve in patients? 14 D. Identification of the Oculomotor Nerves (III), Trochlear Nerves (IV), and Abducens Nerves (VI) Oculomotor Nerves (III) Superior rectus muscle Levator palpebrae CN 03 (III) Oculomotor superioris muscle Medial rectus muscle Inferior oblique muscle Inferior rectus muscle 15 Trochlear Nerves (IV) Superior oblique muscle CN 04 (IV) Trochlear Pons Sphenoid bone Superior orbital fissure 16 Abducens Nerves (VI) Sphenoid bone CN 06 (VI) Abducens Lateral rectus muscle Superior orbital fissure A. In Nervous System Views, select 6. Cranial Nerves. Hide the sphenoid, frontal, and temporal bones to best see the required structures. Select any part of the olfactory nerve and answer the following questions: 1. Select the oculomotor nerves, and select Fade Others. Observe their location, and read their description. a. Are these nerves sensory/motor/mixed (circle one)? b. Where do fibers of this nerve originate? c. Which foramina do the oculomotor nerves pass through? Which cranial bone are these foramina associated with? 17 d. Be able to identify the following effector targets of the oculomotor nerves, along with their functions: i. Levator palpebrae superioris muscle - ii. Superior rectus muscle - iii. Medial rectus muscle - iv. Inferior rectus muscle - v. Inferior oblique muscle - e. Use the search bar to identify these additional targets of the oculomotor nerve. Write their function in the space provided below: i. Ciliary muscles - ii. Pupillary sphincter of the iris - 2. Select the trochlear nerves, and select Fade Others. Observe their location, and read their description. a.
Recommended publications
  • Cranial Nerves
    Cranial Nerves (1,5,7,8,9,10,11 and 12) Slides not included 9th and 10th Cranial 11th and 12th Cranial 8th Cranial Nerve 5th and 7th Cranial 1st Cranial Nerve Nerves Nerves Nerves (3,7,11,12,13,21,23,24) - (10,16) (12,23) Slides included: (14 to 17) *Slides that are not included mostly are slides of summaries or pictures. Nouf Alabdulkarim. Med 435 Olfactory Nerve [The 1st Cranial Nerve] Special Sensory Olfactory pathway 1st order neuron Receptors Axons of 1st order Neurons Olfactory receptors are specialized, ciliated nerve cells The axons of these bipolar cells 12 -20 fibers form the that lie in the olfactory epithelium. true olfactory nerve fibers. Which passes through the cribriform plate of ethmoid → They join the olfactory bulb Preliminary processing of olfactory information It is within the olfactory bulb, which contains interneurones and large Mitral cells; axons from the latter leave the bulb to form the olfactory tract. nd 2 order neuron • It is formed by the Mitral cells of olfactory bulb. • The axons of these cells form the olfactory tract. • Each tract divides into 2 roots at the anterior perforated substance: Lateral root Medial root Carries olfactory fibers to end in cortex of the Uncus & • crosses midline through anterior commissure adjacent part of Hippocampal gyrus (center of smell). and joins the uncrossed lateral root of opposite side. • It connects olfactory centers of 2 cerebral hemispheres. • So each olfactory center receives smell sensation from both halves of nasal cavity. NB. Olfactory pathway is the only sensory pathway which reaches the cerebral cortex without passing through the Thalamus .
    [Show full text]
  • Quantitative Analysis of Axon Collaterals of Single Pyramidal Cells
    Yang et al. BMC Neurosci (2017) 18:25 DOI 10.1186/s12868-017-0342-7 BMC Neuroscience RESEARCH ARTICLE Open Access Quantitative analysis of axon collaterals of single pyramidal cells of the anterior piriform cortex of the guinea pig Junli Yang1,2*, Gerhard Litscher1,3* , Zhongren Sun1*, Qiang Tang1, Kiyoshi Kishi2, Satoko Oda2, Masaaki Takayanagi2, Zemin Sheng1,4, Yang Liu1, Wenhai Guo1, Ting Zhang1, Lu Wang1,3, Ingrid Gaischek3, Daniela Litscher3, Irmgard Th. Lippe5 and Masaru Kuroda2 Abstract Background: The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory coding, and asso- ciative processes have attracted considerable attention as an important part in odor discrimination and olfactory information processing. Associational connections of pyramidal cells in the guinea pig APC were studied by direct visualization of axons stained and quantitatively analyzed by intracellular biocytin injection in vivo. Results: The observations illustrated that axon collaterals of the individual cells were widely and spatially distrib- uted within the PC, and sometimes also showed a long associational projection to the olfactory bulb (OB). The data showed that long associational axons were both rostrally and caudally directed throughout the PC, and the intrinsic associational fibers of pyramidal cells in the APC are omnidirectional connections in the PC. Within the PC, associa- tional axons typically followed rather linear trajectories and irregular bouton distributions. Quantitative data of the axon collaterals of two pyramidal cells in the APC showed that the average length of axonal collaterals was 101 mm, out of which 79 mm (78% of total length) were distributed in the PC.
    [Show full text]
  • Isolated Relative Afferent Pupillary Defect Secondary to Contralateral Midbrain Compression
    OBSERVATION Isolated Relative Afferent Pupillary Defect Secondary to Contralateral Midbrain Compression Cheun Ju Chen, MD; Mia Scheufele, MD; Maushmi Sheth, MD; Amir Torabi, MD; Nick Hogan, MD, PhD; Elliot M. Frohman, MD, PhD Background: Relative afferent pupillary defects are typi- accounts for the relative afferent pupillary defect con- cally related to ipsilateral lesions within the anterior vi- tralateral to the described lesion. sual pathways. Result: Magnetic resonance imaging of the brain revealed a pineal tumor compressing the right rostral midbrain. Objective: To describe a patient who had a workup for headache and was found to have an isolated left relative Conclusion: While rare, a relative afferent pupillary de- afferent pupillary defect without any other neurological fect can occasionally occur secondary to lesions in the findings. postchiasmal pathways. In these circumstances, the pu- pillary defect will be observed to be contralateral to the Design: We review the neuroanatomy of the pupil- side of the lesion. lary light reflex pathway and emphasize the nasotem- poral bias of decussating fiber projections, which Arch Neurol. 2004;61:1451-1453 RELATIVE AFFERENT PUPIL- though retinal fibers concerned with this lary defect (RAPD) is char- reflex transmit information to both the ip- acterized by pupillary dila- silateral and contralateral midbrain, there tion upon illuminating the is a slight crossing bias, with about 53% of eye during the swinging the fibers crossing in the optic chiasm Aflashlight test. The presence of this sign sig- (chiefly derived from the nasal retina) and nifies an abnormality in the transmission 47% remaining ipsilateral. This anatomi- of light information within the pupillary cal organization of the pupillary constric- light constrictor pathway from the retina tor pathway results in the possibility of pro- to the rostral midbrain circuitry involved ducing an RAPD during illumination of the in this reflex.
    [Show full text]
  • Measurement of the Normal Optic Chiasm on Coronal MR Images
    Measurement of the Normal Optic Chiasm on Coronal MR Images Andrew L. Wagner, F. Reed Murtagh, Ken S. Hazlett, and John A. Arrington PURPOSE: To develop an objective method for measuring the optic chiasm and to document its normal range in size. METHODS: Measurements of the height and area of the optic chiasm, made on coronal T1-weighted MR images with the use of commercially available region-of-interest software, were obtained in 114 healthy subjects who had a total of 123 MR studies. A normal range and standard deviation were calculated, and the information was broken down by age and sex. RESULTS: The mean area of the optic chiasm was 43.7 mm2, with a standard deviation of 5.21. The mean width was 14.0 mm, with a standard deviation of 1.68. CONCLUSION: The area and width of the optic chiasm can be measured with the use of commercially available software, which allows an objective estimate of the chiasm’s size. Knowledge of the normal size range of the optic chiasm can be helpful in the early detection of some disorders. Index terms: Optic chiasm; Brain, anatomy; Brain, measurement AJNR Am J Neuroradiol 18:723–726, April 1997 The optic chiasm is an important land- months and that had been interpreted as normal. No pa- mark when interpreting magnetic resonance (MR) tient had suspected visual or endocrine abnormalities. All examinations of the brain. A small chiasm can be the examinations had been performed with a 1.5-T Gen- an indication of several disorders, the most com- eral Electric (Milwaukee, Wis) Signa or 1.5-T Siemens mon of which is septooptic dysplasia (1), and a (Cary, NC) Somatom MR system using routine imaging large chiasm can be the result of glioma, menin- protocols, with additional 3-mm T1-weighted contiguous coronal sections used for measurements.
    [Show full text]
  • Cranial Nerves 1, 5, 7-12
    Cranial Nerve I Olfactory Nerve Nerve fiber modality: Special sensory afferent Cranial Nerves 1, 5, 7-12 Function: Olfaction Remarkable features: – Peripheral processes act as sensory receptors (the other special sensory nerves have separate Warren L Felton III, MD receptors) Professor and Associate Chair of Clinical – Primary afferent neurons undergo continuous Activities, Department of Neurology replacement throughout life Associate Professor of Ophthalmology – Primary afferent neurons synapse with secondary neurons in the olfactory bulb without synapsing Chair, Division of Neuro-Ophthalmology first in the thalamus (as do all other sensory VCU School of Medicine neurons) – Pathways to cortical areas are entirely ipsilateral 1 2 Crania Nerve I Cranial Nerve I Clinical Testing Pathology Anosmia, hyposmia: loss of or impaired Frequently overlooked in neurologic olfaction examination – 1% of population, 50% of population >60 years Aromatic stimulus placed under each – Note: patients with bilateral anosmia often report nostril with the other nostril occluded, eg impaired taste (ageusia, hypogeusia), though coffee, cloves, or soap taste is normal when tested Note that noxious stimuli such as Dysosmia: disordered olfaction ammonia are not used due to concomitant – Parosmia: distorted olfaction stimulation of CN V – Olfactory hallucination: presence of perceived odor in the absence of odor Quantitative clinical tests are available: • Aura preceding complex partial seizures of eg, University of Pennsylvania Smell temporal lobe origin
    [Show full text]
  • Anatomy and Physiology of the Afferent Visual System
    Handbook of Clinical Neurology, Vol. 102 (3rd series) Neuro-ophthalmology C. Kennard and R.J. Leigh, Editors # 2011 Elsevier B.V. All rights reserved Chapter 1 Anatomy and physiology of the afferent visual system SASHANK PRASAD 1* AND STEVEN L. GALETTA 2 1Division of Neuro-ophthalmology, Department of Neurology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA 2Neuro-ophthalmology Division, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA INTRODUCTION light without distortion (Maurice, 1970). The tear–air interface and cornea contribute more to the focusing Visual processing poses an enormous computational of light than the lens does; unlike the lens, however, the challenge for the brain, which has evolved highly focusing power of the cornea is fixed. The ciliary mus- organized and efficient neural systems to meet these cles dynamically adjust the shape of the lens in order demands. In primates, approximately 55% of the cortex to focus light optimally from varying distances upon is specialized for visual processing (compared to 3% for the retina (accommodation). The total amount of light auditory processing and 11% for somatosensory pro- reaching the retina is controlled by regulation of the cessing) (Felleman and Van Essen, 1991). Over the past pupil aperture. Ultimately, the visual image becomes several decades there has been an explosion in scientific projected upside-down and backwards on to the retina understanding of these complex pathways and net- (Fishman, 1973). works. Detailed knowledge of the anatomy of the visual The majority of the blood supply to structures of the system, in combination with skilled examination, allows eye arrives via the ophthalmic artery, which is the first precise localization of neuropathological processes.
    [Show full text]
  • 1. Lateral View of Lobes in Left Hemisphere TOPOGRAPHY
    TOPOGRAPHY T1 Division of Cerebral Cortex into Lobes 1. Lateral View of Lobes in Left Hemisphere 2. Medial View of Lobes in Right Hemisphere PARIETAL PARIETAL LIMBIC FRONTAL FRONTAL INSULAR: buried OCCIPITAL OCCIPITAL in lateral fissure TEMPORAL TEMPORAL 3. Dorsal View of Lobes 4. Ventral View of Lobes PARIETAL TEMPORAL LIMBIC FRONTAL OCCIPITAL FRONTAL OCCIPITAL Comment: The cerebral lobes are arbitrary divisions of the cerebrum, taking their names, for the most part, from overlying bones. They are not functional subdivisions of the brain, but serve as a reference for locating specific functions within them. The anterior (rostral) end of the frontal lobe is referred to as the frontal pole. Similarly, the anterior end of the temporal lobe is the temporal pole, and the posterior end of the occipital lobe the occipital pole. TOPOGRAPHY T2 central sulcus central sulcus parietal frontal occipital lateral temporal lateral sulcus sulcus SUMMARY CARTOON: LOBES SUMMARY CARTOON: GYRI Lateral View of Left Hemisphere central sulcus postcentral superior parietal superior precentral gyrus gyrus lobule frontal intraparietal sulcus gyrus inferior parietal lobule: supramarginal and angular gyri middle frontal parieto-occipital sulcus gyrus incision for close-up below OP T preoccipital O notch inferior frontal cerebellum gyrus: O-orbital lateral T-triangular sulcus superior, middle and inferior temporal gyri OP-opercular Lateral View of Insula central sulcus cut surface corresponding to incision in above figure insula superior temporal gyrus Comment: Insula (insular gyri) exposed by removal of overlying opercula (“lids” of frontal and parietal cortex). TOPOGRAPHY T3 Language sites and arcuate fasciculus. MRI reconstruction from a volunteer. central sulcus supramarginal site (posterior Wernicke’s) Language sites (squares) approximated from electrical stimulation sites in patients undergoing operations for epilepsy or tumor removal (Ojeman and Berger).
    [Show full text]
  • Cranial Nerves II, III, IV & VI (Optic, Oculomotor, Trochlear, & Abducens)
    Cranial Nerves II, III, IV & VI (Optic, Oculomotor, Trochlear, & Abducens) Lecture (13) ▪ Important ▪ Doctors Notes Please check our Editing File ▪ Notes/Extra explanation ه هذا العمل مب ين بشكل أسا يس عىل عمل دفعة 436 مع المراجعة { َوَم نْ يَ َت َو َ ّكْ عَ َلْ ا َّْلل فَهُ َوْ َحْ سْ ُ ُُْ} والتدقيق وإضافة المﻻحظات وﻻ يغ ين عن المصدر اﻷسا يس للمذاكرة ▪ Objectives At the end of the lecture, students should be able to: ✓ List the cranial nuclei related to occulomotor, trochlear, and abducent nerves in the brain stem. ✓ Describe the type and site of each nucleus. ✓ Describe the site of emergence and course of these 3 nerves. ✓ Describe the important relations of oculomotor, trochlear, and abducent nerves in the orbit ✓ List the orbital muscles supplied by each of these 3 nerves. ✓ Describe the effect of lesion of each of these 3 nerves. ✓ Describe the optic nerve and visual pathway. Recall the how these nerves exit from the brain stem: Optic (does not exit from brain stem) Occulomotor: ventral midbrain (medial aspect of crus cerebri) Trochlear: dorsal midbrain (caudal to inferior colliculus) Abducent: ventral Pons (junction b/w pons & pyramid) Brain (Ventral view) Brain stem (Lateral view) Extra-Ocular Muscles 7 muscles: (ترفع جفن العين) .Levator palpebrae superioris 1- Origin: from the roof of the orbit (4) Recti muscles: *Rectus: ماشي على ( Superior rectus (upward and medially 2- الصراط (Inferior rectus (downward and medially 3- المستقيم 4- Medial rectus (medial) (medial) 5- Lateral rectus (lateral) How to remember the 2 فحركته muscles not supplied by نفس اسمه -اسمها عكس وظيفتها- :Oblique muscles (2) 6- Superior oblique (downward and laterally) Oblique: CN3? Superior oblique goes -1 منحرفOrigin: from the roof of the orbit 7- Inferior oblique (upward and laterally) up (superior) and turns around (oblique) a notch يمشي Origin: from the anterior floor or pulley and its supply is عكس كﻻمه NB.
    [Show full text]
  • Spectrum of Clinical and Associated MR Imaging Findings in Children with Olfactory Anomalies
    Published March 17, 2016 as 10.3174/ajnr.A4738 ORIGINAL RESEARCH PEDIATRICS Spectrum of Clinical and Associated MR Imaging Findings in Children with Olfactory Anomalies X T.N. Booth and X N.K. Rollins ABSTRACT BACKGROUND AND PURPOSE: The olfactory apparatus, consisting of the bulb and tract, is readily identifiable on MR imaging. Anom- alous development of the olfactory apparatus may be the harbinger of anomalies of the secondary olfactory cortex and associated structures. We report a large single-site series of associated MR imaging findings in patients with olfactory anomalies. MATERIALS AND METHODS: A retrospective search of radiologic reports (2010 through 2014) was performed by using the keyword “olfactory”; MR imaging studies were reviewed for olfactory anomalies and intracranial and skull base malformations. Medical records were reviewed for clinical symptoms, neuroendocrine dysfunction, syndromic associations, and genetics. RESULTS: We identified 41 patients with olfactory anomalies (range, 0.03–18 years of age; M/F ratio, 19:22); olfactory anomalies were bilateral in 31 of 41 patients (76%) and absent olfactory bulbs and olfactory tracts were found in 56 of 82 (68%). Developmental delay was found in 24 (59%), and seizures, in 14 (34%). Pituitary dysfunction was present in 14 (34%), 8 had panhypopituitarism, and 2 had isolated hypogonadotropic hypogonadism. CNS anomalies, seen in 95% of patients, included hippocampal dysplasia in 26, cortical malformations in 15, malformed corpus callosum in 10, and optic pathway hypoplasia in 12. Infratentorial anomalies were seen in 15 (37%) patients and included an abnormal brain stem in 9 and an abnormal cerebellum in 3. Four patients had an abnormal membranous labyrinth.
    [Show full text]
  • ACNS1721 and ACNS1723 Contouring Atlas
    ACNS1721 and ACNS1723 Contouring Atlas John T. Lucas Jr.1, Stephanie M. Perkins2, David R. Raleigh3, Matthew M. Ladra4, Erin S. Murphy5, Stephanie A. Terezakis4, Thomas E. Merchant1, Daphne A. Haas-Kogan6 Shannon M. MacDonald7 1St. Jude Children’s Research Hospital, 2Washington University School of Medicine in St. Louis, 3University of California San Francisco, 4Johns Hopkins University, 5Cleveland Clinic, 6Dana-Farber Cancer Institute, 7Massachusetts General Hospital 1 Radiotherapy Planning Scans • CT Simulation: – Non-contrast treatment-planning CT scan of the entire head region. – 1.25-1.5mm slice thickness is preferred. – Immobilize patient in supine position using an immobilization device such as an Aquaplast mask over the head. • MRI-CT Fusion: – Register and fuse the relevant MRI sequences to the treatment-planning CT. – Suggested imaging type for delineation of organs at risk and target volumes are detailed in the following slides. 2 OAR General Principles • Please adhere to use of standard name terminology detailed in Section 17.9. • The following imaging is suggested for delineation of organs at risk: – Cochlea, lens: CT planning scan (bone window) – Brainstem, optic n., chiasm: Isovolumetric imaging (MPRAGE or SPGR) T1 or T2 – Body: CT planning scan – Optic Globes: CT planning scan (brain or head and neck window) 3 Required Organs at Risk Description Standard Name Goal Maximum Right Optic Nerve OpticNrv_R D50% < 5400 cGy & D0.1cc < 5600 cGy Left Optic Nerve OpticNrv_L Optic Chiasm OpticChiasm Optic Nerves & Chiasm PRV D50% < 5600 cGy & D10% < 5800 cGy – PRV Brainstem Brainstem D50% < 5240 cGy, D10% < 5600 cGy & D0.1cc < 5880 cGy Spinal Cord SpinalCord D0.1cc < 5400 cGy Right Cochlea Cochlea_R D50% < 3500 cGy (single cochlea) D50% < 2000 cGy – Preferred Left Cochlea Cochlea_L (single cochlea) Body External Unspecified Tissue Optic Globes D50% < 1000 cGy & D10% < 3500 D50% < 2000 cGy & D10% < cGy 5400 cGy 4 See ACNS1721 Protocol Section 17.8 and 17.9 for structure definitions and further detail regarding constraints.
    [Show full text]
  • Clinical Anatomy of the Cranial Nerves Clinical Anatomy of the Cranial Nerves
    Clinical Anatomy of the Cranial Nerves Clinical Anatomy of the Cranial Nerves Paul Rea AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 32 Jamestown Road, London NW1 7BY, UK The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands 225 Wyman Street, Waltham, MA 02451, USA 525 B Street, Suite 1800, San Diego, CA 92101-4495, USA First published 2014 Copyright r 2014 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangement with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
    [Show full text]
  • Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb
    New Research Sensory and Motor Systems Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb Livio Oboti,1 Eleonora Russo,2 Tuyen Tran,1 Daniel Durstewitz,2 and Joshua G. Corbin1 DOI:http://dx.doi.org/10.1523/ENEURO.0175-18.2018 1Center for Neuroscience Research, Children’s National Health System, Washington, DC 20010 and 2Department of Theoretical Neuroscience, Bernstein Center for Computational Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim of Heidelberg University, 68159 Mannheim, Germany Abstract Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on olfactory circuitry remain unknown. Here, using a combination of neuronal tracing approaches, we dissect the connectivity of a cortical amygdala [posteromedial cortical nucleus (PmCo)] feedback circuit innervating the mouse accessory olfactory bulb. Optogenetic activation of PmCo feedback mainly results in feedforward mitral cell (MC) inhibition through direct excitation of GABAergic granule cells. In addition, LED-driven activity of corticofugal afferents increases the gain of MC responses to olfactory nerve stimulation. Thus, through corticofugal pathways, the PmCo likely regulates primary olfactory and social odor processing. Key words: accessory olfactory bulb; amygdala; circuitry; connectivity; mitral cells Significance Statement Olfactory inputs are relayed directly through the amygdala to hypothalamic and limbic system nuclei, regulating essential responses in the context of social behavior. However, it is not clear whether and how amygdala circuits participate in the earlier steps of olfactory processing at the level of the olfactory bulb.
    [Show full text]