Citation 泌尿器科紀要 (1974), 20(11)

Total Page:16

File Type:pdf, Size:1020Kb

Citation 泌尿器科紀要 (1974), 20(11) CONTENTS (ACTA UROLOGICA JAPONICA Vol.20, Title No.11) Author(s) Citation 泌尿器科紀要 (1974), 20(11) Issue Date 1974-11 URL http://hdl.handle.net/2433/121726 Right Type Others Textversion publisher Kyoto University ACTA UROLOGICA JAPONICA Vol. 20, No. 11, November 1974 CONTENTS TREATMENT OF PROSTATIC HYPERTROPHY WITH GESTONORONE CAPROATE Clinical Experience with SH-582 for Prostatic Hypertrophy ........................................................................... T. Nishida and T. Ishikawa••• 703 Effects of 17a-Hydroxy-19-Norprogesterone Caproate (SH-582) on Prostatic Hypertrophy (II) H. Watanabe et al.••• 707 Hormonal Therapy of Prostatic Hypertrophy —Especially on Clinical Effects of SH-582 (19-Nor-17a-Hydroxyprogesterone Caproate)—•••K. Shida et al.••• 711 Clinical Experience with Progesterone Therapy —Effect of Long Term Use ....................................................................................Y. Tabayashi et al.••• 721 Effects of Gestonorone Caproate on Prostatic Hypertrophy II.Histological Changes of the Prostate............................................................K. Ochiai et al.••• 731 Use of SH-582 in Treatment of Prostatic Hypertrophy ........................G. Momose••• 737 Plasma Testosterone Levels Before and After SH-582 •••T. Osada and M. Hosaka••• 745 Treatment of Prostatic Hypertrophy with SH-582 ..............................E. Hachida••• 749 Electron-Microscopic Biochemical Study of the Prostate in Rats —Especially on the Effects of Gestonorone Caproate— .........F . Ishikawa et al.••• 753 Clinical Experiences with SH-582 in Prostatic Hypertrophy.........K. Kuroda et al.••• 759 Treatment of Prostatic Hypertrophy with SH-582 ........................K. Isogai et al.••• 763 Effects of SH-582 on the Excretion of Urinary Steroids ...............K. Okada et al.••• 769 Treatment of Prostatic Hypertrophy with SH-582 .....................J. Ishigami et al.••• 773 Influences of Progesterone Derivatives on the Prostate ......T. Abe and S. Inagaki••• 779 Conservative Treatment of Benign Prostatic Hypertrophy with Gestagen Therapy by Gestonorone Caproate (2nd Report) .....................T. Niijima et al.••• 785 Experience with Gestonorone Caproate (SH-582) in Prostatic Hypertrophy H. Tanaka and T. Shiraishi••• 789 Experience with SH-582 in Benign Prostatic Hypertrophy......T. Kashiwagi et al.••• 793 Further Studies on the Clinical Effects of SH-582 (Gestonorone Caproate) on Benign Prostatic Hypertrophy ..........................................T. Momose et al.••• 799 Clinical Effects of Gestonorone Caproate on Benign Prostatic Hypertrophy S. Kawano et al.••• 803 Progestogen Therapy of Benign Prostatic Hypertrophy K. Nakayama— 809 Please keep this page for binding..
Recommended publications
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • 2011/097571 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date \i\ 11 August 2011 (11.08.2011) 2011/097571 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 38/22 (2006.01) A61P 11/06 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/573 (2006.01) A61P 11/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A61P 29/00 (2006.01) A61P 37/00 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/US201 1/023917 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 7 February 201 1 (07.02.201 1) NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (25) Filing Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/302,325 8 February 2010 (08.02.2010) US GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, 13/021,950 7 February 201 1 (07.02.201 1) US ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant (for all designated States except US): EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, PRAIRIE PHARMACEUTICALS, LLC [US/US]; LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 1041 1 Motor City Drive, Suite 750, Bethesda, MD 20817 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (US).
    [Show full text]
  • Review Use of the New Progestogens in Contraception and Gynaecology
    TOG8_4_229-234 10/5/06 9:17 PM Page 229 The Obstetrician & Gynaecologist 10.1576/toag.8.4.229.27272 www.rcog.org.uk/togonline 2006;8:229–234 Review Review Use of the new progestogens in contraception and gynaecology Author Diana Mansour Key content: • There has been a continuing drive to develop ‘cleaner’and more progesterone receptor-specific progestogens in the hope of enhancing certain qualities and minimising others, such as androgenic properties. • In the last five to 10 years several new progestogens have become available, including: dienogest, drospirenone, nomegestrol acetate, nestorone and trimegestone. • These new progestogens do offer more therapeutic choice but the real way forward appears to lie in the development and incorporation of these in novel delivery systems. Learning objectives: • To learn about the new progestogens available and how they act. • To learn about the uses of the new progestogens in contraception, gynaecological disorders and hormone replacement therapy. Keywords contraception / ethinylestradiol / hormone replacement therapy / new progestogens / progesterone Please cite this article as: Mansour D. Use of the new progestogens in contraception and gynaecology. The Obstetrician & Gynaecologist 2006;8:229–234. Author details Diana Mansour FRCOG FFFP Consultant in Community Gynaecology and Reproductive Health Care Graingerville Clinic, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne, NE4 6BE, UK E-mail: [email protected] (corresponding author) © 2006 Royal College of Obstetricians and Gynaecologists 229 TOG8_4_229-234 10/5/06 9:17 PM Page 230 Review 2006;8:229–234 The Obstetrician & Gynaecologist Introduction There has been a continuing drive to develop In recent years, a number of new hormonal ‘cleaner’and more progesterone receptor-specific products for use in gynaecology have been progestogens in the hope of enhancing certain launched.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • Protocol (Revised) for Scoping Review of Adverse Health Effects
    PROTOCOL FOR SCOPING REVIEW OF Adverse Health Effects Associated with Prenatal Exposure to Progestogens July 31, 2020 Office of Health Assessment and Translation Division of the National Toxicology Program National Institute of Environmental Health Sciences National Institutes of Health U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Date Original Protocol Finalized: September 26, 2018 Date Revised Protocol Published: July 31, 2020 Documentation of Revisions to the Protocol: The principal revisions are detailed in the Protocol History and Revision Table on Page 10 including the reasons for each revision. Text that was deleted is crossed out and inserted text is underlined. OHAT Scoping Review Protocol on Progestogens, revised July 31, 2020 TABLE OF CONTENTS Background and Significance .............................................................................................................. 1 Background ......................................................................................................................................... 1 Significance ......................................................................................................................................... 1 Objective and Specific Aims ................................................................................................................ 2 Objective ............................................................................................................................................. 2 Specific Aims ......................................................................................................................................
    [Show full text]
  • RR-17: Scoping Review of Prenatal
    NTP RESEARCH REPOrt ON THE SCOPING REVIEW OF PRENATAL EXPOSURE TO PROGESTOGENS AND ADVERSE HEALTH OUTCOMES NTP RR 17 SEPTEMBER 2020 NTP Research Report on the Scoping Review of Prenatal Exposure to Progestogens and Adverse Health Outcomes Research Report 17 September 2020 National Toxicology Program Public Health Service U.S. Department of Health and Human Services ISSN: 2473-4756 Research Triangle Park, North Carolina, USA Scoping Review of Prenatal Exposure to Progestogens and Adverse Health Outcomes Foreword The National Toxicology Program (NTP), established in 1978, is an interagency program within the Public Health Service of the U.S. Department of Health and Human Services. Its activities are executed through a partnership of the National Institute for Occupational Safety and Health (part of the Centers for Disease Control and Prevention), the Food and Drug Administration (primarily at the National Center for Toxicological Research), and the National Institute of Environmental Health Sciences (part of the National Institutes of Health), where the program is administratively located. NTP offers a unique venue for the testing, research, and analysis of agents of concern to identify toxic and biological effects, provide information that strengthens the science base, and inform decisions by health regulatory and research agencies to safeguard public health. NTP also works to develop and apply new and improved methods and approaches that advance toxicology and better assess health effects from environmental exposures. NTP reports the findings from many of its studies in the NTP Technical Report and Monograph series. NTP uses the Research Report series, which began in 2016, to report on work that does not fit readily into one of those two series, such as pilot studies, assay development or optimization studies, literature surveys or scoping reviews, and handbooks on NTP procedures or study specifications.
    [Show full text]
  • Follicle-Stimulating Hormone/Gestonorone Caproate 2105
    Follicle-stimulating Hormone/Gestonorone Caproate 2105 Fosfestrol Sodium (BANM, rINNM) cle stimulating hormone is effective, safe and convenient: results Uses and Administration of a controlled, randomized, multicentre trial. Hum Reprod 2000; Fosfestrol sódico; Fosfestrol Sodique; Natrii Fosfestrolum. 15: 1490–8. Correction. ibid.; 1877. Gestodene is a progestogen (see Progesterone, p.2125) Натрий Фосфэстрол 3. The North American Ganirelix Study Group. Efficacy and safety structurally related to levonorgestrel. It is used as the of ganirelix acetate versus leuprolide acetate in women undergo- C18H18Na4O8P2 = 516.2. ing controlled ovarian hyperstimulation. Fertil Steril 2001; 75: progestogenic component of combined oral contracep- CAS — 23519-26-8 (fosfestrol tetrasodium xH2O); 4719- 38–45. tives (see p.2069); a typical daily dose is 75-9 (anhydrous fosfestrol tetrasodium). 4. European and Middle East Orgalutran Study Group. Comparable 75 micrograms in monophasic preparations, and 50 to ATC — L02AA04. clinical outcome using the GnRH antagonist ganirelix or a long ATC Vet — QL02AA04. protocol of the GnRH agonist triptorelin for the prevention of 100 micrograms in triphasic preparations. Gestodene Pharmacopoeias. In Br., which specifies xH O. premature LH surges in women undergoing ovarian stimulation. is also used orally as the progestogenic component of 2 Hum Reprod 2001; 16: 644–51. BP 2008 (Fosfestrol Sodium). A white or almost white powder. 5. Griesinger G, et al. Gonadotropin-releasing hormone antagonists menopausal HRT (see p.2076) in a regimen of 25 or Freely soluble in water; practically insoluble in dehydrated alco- for assisted reproductive techniques: are there clinical differenc- 50 micrograms daily for 12 days of a 28-day cycle. hol and in ether.
    [Show full text]
  • Pharmacology of Estrogens and Progestogens: Influence of Different Routes of Administration
    CLIMACTERIC 2005;8(Suppl 1):3–63 Pharmacology of estrogens and progestogens: influence of different routes of administration H. Kuhl Department of Obstetrics and Gynecology, J. W. Goethe University of Frankfurt, Germany Key words: ESTROGENS, PROGESTOGENS, PHARMACOKINETICS, PHARMACODYNAMICS, HORMONE REPLACEMENT THERAPY ABSTRACT This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormone replacement therapy. The paper describes the mechanisms of action, the relation between structure and hormonal activity, differences in hormonal pattern and potency, peculiarities in the properties of certain steroids, tissue-specific effects, and the metabolism of the available estrogens and progestogens. The influence of the route of administration on pharmacokinetics, hormonal activity and metabolism is presented, and the effects of oral and transdermal treatment with estrogens on tissues, clinical and serum parameters are compared. The effects of oral, transdermal (patch and gel), intranasal, sublingual, buccal, vaginal, subcutaneous and intramuscular adminis- tration of estrogens, as well as of oral, vaginal, transdermal, intranasal, buccal, intramuscular and intrauterine application of progestogens are discussed. The various types of progestogens, their receptor interaction, hormonal pattern and the hormonal activity of certain metabolites are described in detail. The structural formulae, serum concentrations, binding affinities to steroid receptors and serum binding globulins, and the relative potencies of the available estrogens and progestins are presented. Differences in the tissue-specific effects of the various compounds and regimens and their potential implications with the risks and benefits of hormone replacement therapy are discussed. INTRODUCTION The aim of any hormonal treatment of postmen- tance of pharmacological knowledge for an opausal women is not to restore the physiological optimal use of hormone therapy.
    [Show full text]
  • Progesterone in Assisted Reproduction: Classification, Pharmacology and Its Clinical Coorelation: a Commentary
    Scient Women’s Health & Gynecology Open Access Exploring the World of Science ISSN: 2369-307X Research Article Progesterone in Assisted Reproduction: Classification, Pharmacology and Its Clinical Coorelation: A Commentary This article was published in the following Scient Open Access Journal: Women’s Health & Gynecology Received January 22, 2020; Accepted January 31, 2020; Published February 06, 2020 Rathod K1*, Purohit P2, Kunde K3 and Narvekar N4 Abstract 1Consultant in Obstetrics and Gynaecology Whipps The modulating effects of progesterone on endometrium structure and function are the Cross Hospital, London UK basis for successful outcome in reproductive treatments. Considering this, progesterone 2Consultant in Obstetrics and Gynaecology Princess has a big role in treatment of infertility and supporting the ongoing pregnancy. In this review Royal University Hospital, London UK article we have attempted to review different forms of progesterone, their metabolism 3Consultant Obstetrics and Gynaecologist, Guys and in the body and the role played by exogenous as well as endogenous progesterone in St Thomas’ Hospital, London UK assisted reproductive technologies (ART). Elevated serum progesterone levels at the end 4Consultant and Sub-specialist in Assisted of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing Reproduction Kings College Hospital, London UK pregnancy rate in IVF cycles due to reduced endometrial receptivity. Keywords: Progesterone, luteal phase support (LPS), in-vitro fertilization (IVF), Ovarian hyperstimulation (OHSS), Controlled ovarian stimulation (COS), Artificial reproductive technology (ART). Learning objectives Progesterone • • Mechanism of action of Progesterone • Classification of progesterone • Pharmacokinetics and dynamics of progesterone • Preparation of progesterone’s • Potential advantages of progesterone in assisted reproduction •IntroductionCons of elevelated serum progesterone levels in ART It is a natural hormone (C-21 steroid) produced mainly by the theca lutein cells of the corpus luteum.
    [Show full text]
  • Title Allylestrenolによる前立腺肥大症の治療 Author(S) 高山, 秀則; 大城, 清; 林, 正 Citation 泌尿器科紀
    Title Allylestrenolによる前立腺肥大症の治療 Author(s) 高山, 秀則; 大城, 清; 林, 正 Citation 泌尿器科紀要 (1977), 23(4): 409-419 Issue Date 1977-06 URL http://hdl.handle.net/2433/122084 Right Type Departmental Bulletin Paper Textversion publisher Kyoto University 409 〔泌尿紀要23巻4号1977年5・6月〕 AllyleStrenolによる前立腺肥大症の治療 倉敷申央病院泌尿器科(医長 高山秀則博士) 高 山. 雨 則 大 紅 清 林 正 TREATMENT OF BENIGN PROSTATIC HYPERTROPHY WITH ALLYLESTRENOL Hidenori TAKAyAMA, Kiyoshi OsHiRo and Tadashi HAyAsHi From the DePartment of Urology, Kurashiki Central HosPital, Okayama r(]hief:H。 Taた4γama,ルf.エ).ノ Fifteen patients with BPH received a progestational agent, allylestrenol (Gestanon) daily for periods ranging to at least 3 months or more. . Dysuria, being complained by 12 patients, was judged to have disappeared in 8 patients, lessened in 2 and’remained unchanged’in 2. ’ Of 11 patients with complaint of frequent urination, 6 patients returned to normal frequency and 3 showed 4 decrease of frequency. Residual urine volumes decreased in 13 of 15 patients beginning one to two months after start of therapy and increased in 2. Reduction in size of the prostate as measured by the cystourethrogram was seen in 5 of 1 1 patients. But in all the patients, no remarkable change in size of the gland was noted under rectal examination. Biopsy specimen for’ histological examination was successfully obtained before and after allyl一 . estrenol administration in 4 patients. Flattening of epithelia.1 projection into the lumen, dilatation of acini and decrease in epithelial cell heights were demonstrated in 2 of 4 patients.
    [Show full text]
  • Endometrial Cancer -Pregnancy -Uterine Or Cervical Polyps Complications -Uterine Leiomyomata -Trauma Risk Factors for Endometrial Cancer (RR = RelaVe Risk)
    Endocrine causes Infections -Cushing’s disease -Chlamidia -Immature hypothalamic- -Gonorrhea pituitary axis -PID -Hyperprolactinemia -Hypothyroidism Medications -Menopause -Obesity -Hormonal agents -PCOD -Low dose OCs CAUSES OF AUB -Premature ovarian failure -IUD (differential -NSAIDs analysis Structural lesions -POP (“mini pill”} and diagnosis) -Tamoxifen -Adenomyosis -Warfarin -Coagulopathies -Condyloma accuminata Pregnancy -Dysplastic or malignant lesions of cervix or vagina -Ectopic pregnancy -Endometriosis -Incomplete abortion -Endometrial cancer -Pregnancy -Uterine or cervical polyps complications -Uterine leiomyomata -Trauma Risk factors for endometrial cancer (RR = relave risk) Age - 75% of cases occur aer menopause RR (age > 60 years) = 5.2 with peak incidence in the late 60s. Obesity - especially upper body fat. This may RR= 3 to 10 be secondary to increased estrogen producon and bioavailability. Polycysc ovary disease. RR = 5.2 Unopposed exogenous estrogen. RR = 2 to 14 When progesns are added (oral contracepves RR= 0.5 to 1 or with replacement therapy), relave risk is less than for the general populaon. Diabetes (all types grouped). Personal or family history of ovarian or breast RR = 2 to 2.8 cancer. Women who are overweight and have had breast cancer are at even greater risk. Nulliparity. RR = 1.3 Late menopause. RR entering menopause aer age 52 = 2.5 Tamoxifen therapy - Use for greater than one year is an independent risk factor. RR = 7.5 Basic FIGO classificaon system (PALM-COEIN) for causes of abnormal uterine bleeding
    [Show full text]
  • Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)
    REVIEWS Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review) DOI: 10.17691/stm2021.13.1.11 Received June 23, 2020 T.A. Fedotcheva, MD, DSc, Senior Researcher, Research Laboratory of Molecular Pharmacology Pirogov Russian National Research Medical University, 1 Ostrovitianova St., Moscow, 117997, Russia This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins have been studied. Data on the clinical use of gestagens by nosological groups are presented. Particular attention is paid to progesterone, megestrol acetate, medroxyprogesterone acetate due to broadening of their spectrum of action. The possibilities of using gestagens as neuroprotectors, immunomodulators, and chemosensitizers are considered. Key words: progesterone; megestrol acetate; medroxyprogesterone acetate; gestagens; progesterone receptors. How to cite: Fedotcheva T.A. Clinical use of progestins and their mechanisms of action: present and future (review). Sovremennye tehnologii v medicine 2021; 13(1): 93, https://doi.org/10.17691/stm2021.13.1.11 Introduction binds to nuclear receptors (transcription factors), it is accompanied by genomic effects that develop over Progesterone is a natural endogenous steroid sex several hours and days, leading to specific physiological hormone secreted by the ovaries. It interacts with and morphological changes in target organs, which is its specific receptors in the reproductive
    [Show full text]