Progesterone Receptor NR3C3

Home , Altrenogest, Asoprisnil, Chlormadinone acetate, Estradiol dipropionate, Gestonorone caproate, Nonsteroidal

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

www.MedChemExpress.com 1 Progesterone Receptor Inhibitors, Agonists, Antagonists, Activators & Modulators

17α-Hydroxyprogesterone Altrenogest (17-Hydroxyprogesterone; 17-OHP) Cat. No.: HY-B0891 (Allyltrenbolone; RU2267) Cat. No.: HY-B0521

17α-Hydroxyprogesterone (17-Hydroxyprogesterone) Altrenogest (Allyltrenbolone) is a progestogen is an endogenous progestogen as well as chemical structurally related to veterinary steroid intermediate in the biosynthesis of other steroid trenbolone. hormones, including the corticosteroids and the androgens and the estrogens.

Purity: 99.94% Purity: 99.80% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Asoprisnil Chlormadinone acetate (J867) Cat. No.: HY-119433 Cat. No.: HY-B1095

Asoprisnil (J867), a selective progesterone Chlormadinone acetate is a steroidal progestin, receptor modulator, exhibits mixed progesterone with antiandrogen and antiestrogenic effects. agonist and antagonist effects on various progesterone targeted tissues in animal and human.

Purity: 98.30% Purity: ≥98.0% Clinical Data: Clinical Data: Launched Size: 1 mg Size: 10 mM × 1 mL, 100 mg

Cridanimod Desogestrel Cat. No.: HY-W011890 (Org-2969) Cat. No.: HY-12516

Cridanimod is a potent progesterone receptor (PR) Desogestrel(Org-2969) is a third-generation activator mediated through induction of IFNα and 19-nortestosterone derivative progestogen; is IFNβ expression. Cridanimod is a small-molecule contained in many oral contraceptive preparations, immunomodulator and interferon inducer. both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).

Purity: 99.97% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Dienogest Drospirenone (STS 557) Cat. No.: HY-B0084 (Dihydrospirorenone) Cat. No.: HY-B0111

Dienogest(STS-557) is a specific progesterone Drospirenone(Dihydrospirorenone) is a synthetic receptor agonist with potent oral endometrial progestin that is an analog to spironolactone. activity and is used in the treatment of endometriosis. Target: progesterone receptor agonist Dienogest is an orally active synthetic progesterone (or progestin). Purity: 99.83% Purity: 98.45% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Dydrogesterone Estradiol dipropionate Cat. No.: HY-B0257A Cat. No.: HY-B2245

Dydrogesterone is a potent, orally active Estradiol dipropionate is a combined progestogen indicated in a wide variety of estrogen-progesterone, acts as an estrogen and gynaecological conditions related to progesterone progesterone agonist. deficiency.

Purity: 99.98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

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Ethynodiol diacetate Gestodene (Ethynodiol acetate) Cat. No.: HY-B1089 (SHB 331; WL 70) Cat. No.: HY-B0110

Ethynodiol diacetate (Ethynodiol acetate) is a Gestodene(SHB 331;WL 70) is a progestogen hormonal steroidal progestin which is used as a hormonal contraceptive. Target: Estrogen Receptor/ERR contraceptive, it has relatively little or no Gestodene is androgenically neutral, meaning that potency as an androgen,has significant estrogenic contraceptive pills containing gestodene do not effects. exhibit the androgenic side effects (e.g.

Purity: 98.58% Purity: 99.69% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Gestonorone Capronate Levonorgestrel (Gestonorone caproate) Cat. No.: HY-U00091 (D-Norgestrel) Cat. No.: HY-B0257

Gestonorone Capronate is a progestin for the Levonorgestrel is a synthetic progestogen used as treatment of benign prostatic hypertrophy and an active ingredient in some hormonal endometrial cancer. contraceptives.

Purity: >98% Purity: 99.13% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Medroxyprogesterone Medroxyprogesterone acetate (17α-Hydroxy-6α-methylprogesterone; U8840) Cat. No.: HY-B0648 (Medroxyprogesterone 17-acetate; Farlutin) Cat. No.: HY-B0469

Medroxyprogesterone is a progestin, a synthetic Medroxyprogesterone acetate is a widely used variant of the human hormone progesterone and a synthetic steroid by its interaction with potent progesterone receptor agonist. Target: progesterone, androgen and glucocorticoid Progesterone Receptor Medroxyprogesterone (MP), is receptors. a steroidal progestin drug which was never marketed for use in humans. Purity: 99.43% Purity: 99.82% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g Size: 10 mM × 1 mL, 100 mg, 500 mg

Medroxyprogesterone acetate D3 Megestrol acetate (Medroxyprogesterone 17-acetate D3; Farlutin D3) Cat. No.: HY-B0469S Cat. No.: HY-13676

Medroxyprogesterone acetate D3 is deuterium Megestrol acetate is a synthetic and orally active labeled Medroxyprogesterone acetate. progesteronal agent. Megestrol acetate is Medroxyprogesterone acetate is a widely used effective as an appetite stimulant for wasting synthetic steroid by its interaction with syndromes such as cachexia. Megestrol acetate progesterone, androgen and glucocorticoid decreases nuclear and cytosol androgen receptors receptors. human BPH tissue. Purity: 98.06% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Mifepristone Nestoron (RU486; RU 38486) Cat. No.: HY-13683 (ST-1435; Elcometrine) Cat. No.: HY-13071

Mifepristone (RU486) is a progesterone receptor Nestoron (ST-1435) is a 19-norprogesterone (PR) and glucocorticoid receptor (GR) antagonist derivative with high affinity and selectivity for with IC50s of 0.2 nM and 2.6 nM in in vitro assay. progesterone receptors. Nestoron is a highly selective and potent progestogen that can be used as a hormonal contraceptive.

Purity: 98.67% Purity: 99.41% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

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Nomegestrol Nomegestrol acetate Cat. No.: HY-105634 Cat. No.: HY-105634A

Nomegestrol is a potent and orally available Nomegestrol acetate is a potent, highly selective progestin, acts as a selective full progesterone progestogen, which is characterized as a full

receptor agonist, with a Kd of 5.44 nM for rat agonist at the progesterone receptor, with no or uterine progesterone receptor, and has moderate minimal binding to other steroid receptors, antiandrogenic activity and strong antiestrogenic including the androgen and glucocorticoid activity. receptors. Purity: >98% Purity: 98.50% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Norethindrone Norethindrone acetate (Norethisterone) Cat. No.: HY-B0554 (19-Norethindrone acetate) Cat. No.: HY-B1710

Norethindrone is a female progestin approved by Norethindrone acetate is a female hormone used for FDA for the treatment of endometriosis, uterine the research of endometriosis. bleeding caused by abnormal hormone levels, and secondary amenorrhea.

Purity: 99.57% Purity: 99.41% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Norethisterone enanthate Norgestimate (Norigest) Cat. No.: HY-A0285 Cat. No.: HY-W013172

Norethisterone enanthate is a long-acting Norgestimate, a synthetic progesterone analog, is parenteral progestogen. Norethisterone enanthate an orally active progestin with highly selective is orally active. progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive.

Purity: 99.50% Purity: ≥99.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 250 mg, 500 mg Size: 10 mg

PF-02413873 PF-3882845 (PF-2413873) Cat. No.: HY-11028 Cat. No.: HY-12738

PF-02413873 (PF-2413873) is a potent selective, PF-3882845 is a remarkably high affinity selective fully competitive and orally active nonsteroidal and orally efficacious mineralocorticoid

progesterone receptor (PR) antagonist, with a Ki receptor (MR binding IC50=2.7 nM) antagonist of 2.6 nM. PF-02413873 can block progesterone for hypertension and nephropathy. PF-3882845 also binding and PR nuclear translocation, and inhibit binds to progesterone receptor (PR) with the

endometrial growth in vivo. binding IC50 of 310 nM. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg Size: 1 mg, 5 mg

Progesterone Tanaproget (Pregn-4-ene-3,20-dione) Cat. No.: HY-N0437 (NSP-989) Cat. No.: HY-15606

Progesterone is a steroid hormone that regulates Tanaproget (NSP-989) is a novel nonsteroidal the menstrual cycle and is crucial for pregnancy. progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.

Purity: 99.66% Purity: 99.93% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 1 g, 5 g Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

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Tibolone Ulipristal Cat. No.: HY-123047 (CDB-3236; Deacetyl CDB-2914) Cat. No.: HY-14959

Tibolone is a broad spectrum gonadal steroid Ulipristal (CDB 3236) is a selective progesterone agonist with progestagenic, androgenic, and receptor modulator (SPRM). Ulipristal binds to estrogenic activities. Tibolone can be used for the progesteron receptor, thereby inhibiting postmenopausal osteoporosis research. PR-mediated gene expression, and interfering with progesterone activity in the reproductive system.

Purity: 99.68% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Phase 4 Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Ulipristal acetate (CDB-2914) Cat. No.: HY-16508

Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells.

Purity: 99.93% Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg