Anti-ERP29 Monoclonal Antibody, Clone FQS23500(C) (DCABH-6341) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-ERP29 monoclonal antibody, clone FQS23500(C) (DCABH-6341) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to ERp29

Antigen Description Proper protein folding and post-translational modifications are essential for secretory protein export out of the endoplasmic reticulum. This task is accomplished by chaperone proteins such as protein disulfide isomerase (PDI), GRP94, and BiP. A recently characterized protein, designated ERp29, is closely related to these chaperone proteins and appears to be upregulated during ER stress conditions. ERp29 is a soluble 259-residue protein that is localized to the lumen of the endoplasmic reticulum in all mammalian cells. Research has shown that there are two primary domains within ERp29. The first is the C-terminal region that is a novel, all helical, fold that is most likely involved with ERp29 retention to the ER. The second is the N-terminal region that resembles that of PDI's thioredoxin module. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER.

Immunogen Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human ERp29 aa 50-150 (internal sequence) (Cysteine residue). The exact sequence is proprietary.Database link: P30040

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Clone FQS23500(C)

Purity Tissue culture supernatant

Conjugate Unconjugated

Applications IHC-P, WB, ICC/IF

Positive Control HeLa, HepG2, MCF7 and OVCAR-3 cell lysates; HeLa cells; Human kidney and liver tissues.

Format Liquid

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Preservative None

Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Ship Shipped at 4°C.

GENE INFORMATION

Gene Name ERP29 endoplasmic reticulum protein 29 [ Homo sapiens ]

Official Symbol ERP29

Synonyms ERP29; endoplasmic reticulum protein 29; C12orf8, chromosome 12 open reading frame 8; endoplasmic reticulum resident protein 29; ERp28; ERp29; ERp31; PDI DB; PDIA9; protein disulfide isomerase family A; member 9; endoplasmic reticulum resident protein 28

Entrez Gene ID 10961

Protein Refseq NP_001029197

UniProt ID P30040

Chromosome Location 12q24.13

Pathway Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;

Function protein disulfide isomerase activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]