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Home , Clorindione, Otamixaban

Acetylsalisylsyre, og antikoagulasjon – PICO 1.4

Kontaktperson: Liv Hege Kateraas og Bent Indredavik Søk: Marita Heintz Kommentar: Søk etter systematiske oversikter Tidsbruk: 25 timer

Pico-skjema:

Spørsmålet i PICO format

Hva handler spørsmålet om? Comparison Populasjon Outcome(s) Intervensjon (tiltak) (sammenligning/ (pasient) (utfall/effekt) kontroll)

Har pasienter med TIA/ TIA/ akutt hjerneinfarkt Tillegg av clopidogrel Hjerneinfarkt / pasienter som bruker eller antikoagulasjon vaskulære aktutt hjerneinfarkt acetylsalicylsyre hendelser / død som bruker acetylsalisylsyre, effekt av clopidogrel eller antikoagulasjon i tillegg?

Database: Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Dato: 27.05.2016 Antall treff: 191 (186 etter sletting av interne dubletter)

stroke/ or cerebral infarction/ or dementia, multi-infarct/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or stroke, lacunar/ or brain 1 ischemia/ or carotid artery, internal, dissection/ or carotid artery thrombosis/ or "intracranial 136566 embolism and thrombosis"/ or intracranial embolism/ or intracranial thrombosis/ or vertebral artery

dissection/

2 (stroke or cerebrovasc* or cerebral vasc*).tw. 212662

((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or 84829 infarct* or thrombo* or emboli*)).tw.

4 Ischemic Attack, Transient/ 18590

(TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or 5 16514 brain or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw.

6 or/1-5 304555

7 / or Aspirin, Drug Combination/ 40351

(acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or 58721 asawin or aspirin or aspirina).mp.

(("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or 9 acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or 9560 acetylosalicylic or acetylsalicyclic) adj1 acid).mp.

10 or/7-9 61478

11 /aa [Analogs & Derivatives] 7203

(clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 12 33931 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp.

13 exp / 192004

14 exp Blood Coagulation/ai, de [Antagonists & Inhibitors, Drug Effects] 17407

15 exp Blood Coagulation Factors/ai [Antagonists & Inhibitors] 14008

16 (anticoagul* or antithromb*).tw. 93566

17 exp / 17816

18 therapy/ 637

19 /ai [Antagonists & Inhibitors] 3500

( or MD805 or MD-805 or or or melagatran or efegatran or 20 flovagatran or or napsagatran or or or hirudin$ or desirudin or 9909 desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp.

(antistasin or or or du 176b or eribaxaban or or or

or razaxaban or or yagin or ym 150 or ym150 or LY517717 or or 21 4851 or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp.

22 / 51329

23 exp heparin, low-molecular-weight/ 10694

24 / 921

(heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or 25 tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or 132454

or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or

cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp.

26 Factor Xa Inhibitors/ 2826

((("direct thrombin" or "factor xa" or "factor 10a" or fXa or "autoprothrombin c" or thrombokinase or 27 6106 "activated " or "factor 10") adj2 inhibit*) or xabans).mp.

28 exp Vitamin K/ai [Antagonists & Inhibitors] 1969

29 ("*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw. 3576

Warfarin/ or 4-hydroxycoumarins/ or / or / or dicumarol/ or ethyl 30 32541 biscoumacetate/ or / or / or coumafos/

(* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or or or or marevan or * or coumadin* or jantoven or lawarin or waran or warfant or 31 46091 adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin).mp.

32 (((new or novel) adj2 oral *) or NOAC).tw. 2110

33 Dabigatran/ or Rivaroxaban/ 2438

(dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana 34 6391 or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E).mp.

35 or/11-34 356193

36 6 and 10 and 35 5452

37 ((systematic* or literature) adj2 review*).mp. 197770

38 (metaanalys* or meta analys*).mp. or (meta analysis or review).pt. 2190404

39 37 or 38 2254220

40 36 and 39 1822

41 limit 40 to yr="2014 -Current" 191

Database: Embase 1974 to 2016 May 26 Dato: 27.05.2016 Antall treff: 247 (235 etter sletting av interne dubletter)

cerebrovascular accident/ or brain infarction/ or multiinfarct dementia/ or cerebral artery disease/ or 1 lacunar stroke/ or brain ischemia/ or carotid artery injury/ or carotid artery thrombosis/ or brain 261586 embolism/ or occlusive cerebrovascular disease/ or artery dissection/

2 (stroke or cerebrovasc* or cerebral vasc*).tw. 310963

((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or infarct* 115416 or thrombo* or emboli*)).tw.

4 transient ischemic attack/ 29162

(TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain 5 26044 or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw.

6 or/1-5 469116

7 acetylsalicylic acid/ or acetylsalicylic acid plus dipyridamole/ 177684

(acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or 103758 asawin or aspirin or aspirina).mp.

(("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or 9 acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or 179662 acetylosalicylic or acetylsalicyclic) adj1 acid).mp.

10 or/7-9 187544

11 clopidogrel/ 44865

(clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 12 46847 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp.

exp anticoagulant agent/ or anticoagulant therapy/ or exp thrombin inhibitor/ or exp blood clotting 13 571957 factor 10a inhibitor/ or 4 hydroxycoumarin/ or coumarin/ or coumarin derivative/

14 (anticoagul* or antithromb*).tw. 132351

(argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or 15 flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin$ or desirudin or 23701

desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp.

(antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or 16 14528 edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp.

(heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or 17 230987 danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp.

((("direct thrombin" or "factor xa" or "factor 10a" or fXa or "autoprothrombin c" or thrombokinase or 18 8494 "activated factor X" or "factor 10") adj2 inhibit*) or xabans).mp.

19 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw. 6038

(coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar*

or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione 20 or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or 109033 aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin).mp.

21 (((new or novel) adj2 oral anticoagulant*) or NOAC).tw. 3865

(dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana or savaysa or 22 17987 "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E).mp.

23 or/11-22 663766

24 6 and 10 and 23 26719

25 acetylsalicylic acid plus clopidogrel/ 309

26 6 and 25 141

27 24 or 26 26719

meta analysis/ or "systematic review"/ or ((systematic* adj2 review*) or metaanalys* or meta 28 239692 analys*).tw.

29 27 and 28 1666

30 limit 29 to yr="2014 -Current" 247

Database: The Cochrane Library (Cochrane Database of Systematic Reviews: Issue 5 of 12, May 2016; Database of Abstracts of Reviews of Effect: Issue 2 of 4, April 2015; Health Technology Assessment Database: Issue 2 of 4, April 2016, NHS Economic Evaluation Database : Issue 2 of 4, April 2015) Dato: 27.05.2016 Antall treff: 22 (13 Cochrane, 3 other, 1 tech.ass og 5 eco.eval.)

#1 [mh ^stroke] 5845 #2 [mh ^"cerebral infarction"] 541 #3 [mh ^"dementia, multi-infarct"] 62 #4 [mh ^"infarction, anterior cerebral artery"] 4 #5 [mh ^"infarction, middle cerebral artery"] 106 #6 [mh ^"infarction, posterior cerebral artery"] 3 #7 [mh ^"stroke, lacunar"] 19 #8 [mh ^"brain ischemia"] 1216 #9 [mh ^"carotid artery, internal, dissection"] 5 #10 [mh ^"carotid artery thrombosis"] 18 #11 [mh ^"intracranial embolism and thrombosis"] 84 #12 [mh ^"intracranial embolism"] 127 #13 [mh ^"intracranial thrombosis"] 35 #14 [mh ^"vertebral artery dissection"] 7 #15 (stroke or cerebrovasc* or cerebral vasc*):ti,ab,kw in Cochrane Reviews 470 (Reviews and Protocols) #16 (stroke or cerebrovasc* or cerebral vasc*) in Other Reviews, Technology 3235 Assessments and Economic Evaluations #17 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or 135 intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) near/5 (ischemi* or ischaemi* or ischiemi* or ischoemi*or infarct* or thrombo* or emboli*)):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #18 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or 605 intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) near/5 (ischemi* or ischaemi* or ischiemi* or ischoemi* or infarct* or thrombo* or emboli*)) in Other Reviews, Technology Assessments and Economic Evaluations #19 [mh ^"Ischemic Attack, Transient"] 611 #20 (TIA or TIAs or ((ischemic or ischaemic) next (attack or attack? or seizure or 37 seizure?)) or (transient next (brainstem or brain or "brain stem" or cerebral) next (ischemi* or ischaemi* or ischiemi* or ischoemi*))):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #21 (TIA or TIAs or ((ischemic or ischaemic) next (attack or attack? or seizure or 287 seizure?)) or (transient next (brainstem or brain or "brain stem" or cerebral) next (ischemi* or ischaemi* or ischiemi* or ischoemi*))) in Other Reviews, Technology Assessments and Economic Evaluations #22 [mh ^Aspirin] 4744 #23 [mh ^"Aspirin, Dipyridamole Drug Combination"] 12

#24 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum 107 acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #25 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum 864 acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) in Other Reviews, Technology Assessments and Economic Evaluations #26 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or 10 acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) near/1 acid):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #27 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or 76 acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) near/1 acid) in Other Reviews, Technology Assessments and Economic Evaluations #28 MeSH descriptor: [Ticlopidine] this term only and with qualifier(s): [Analogs 1121 & derivatives - AA] #29 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or 47 "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #30 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or 586 "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) in Other Reviews, Technology Assessments and Economic Evaluations #31 [mh anticoagulants] 4435 #32 MeSH descriptor: [Blood Coagulation] explode all trees and with qualifier(s): 1456 [Drug effects - DE] #33 (anticoagul* or antithromb*):ti,ab,kw in Cochrane Reviews (Reviews and 160 Protocols) #34 (anticoagul* or antithromb*) in Other Reviews, Technology Assessments and 1288 Economic Evaluations #35 [mh antithrombins] 578 #36 [mh ^"hirudin therapy"] 79 #37 MeSH descriptor: [Thrombin] this term only and with qualifier(s): [Analogs & 0 derivatives - AA] #38 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or 9 melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or

hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #39 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or 171 melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil) in Other Reviews, Technology Assessments and Economic Evaluations #40 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or 15 fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #41 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or 167 fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) in Other Reviews, Technology Assessments and Economic Evaluations #42 [mh ^heparin] 3103 #43 [mh "heparin, low-molecular-weight"] 1840 #44 [mh ^heparinoids] 54 #45 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or 116 mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy- 222 or cy216 or cy-216 or dermatan sul* or heparan sul*):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #46 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or 756 mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy- 222 or cy216 or cy-216 or dermatan sul* or heparan sul*) in Other Reviews, Technology Assessments and Economic Evaluations #47 [mh ^"Factor Xa Inhibitors"] 279 #48 ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or 12 "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") near/2 inhibit*) or xabans):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #49 ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or 63 "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") near/2 inhibit*) or xabans) in Other Reviews, Technology Assessments and Economic Evaluations #50 MeSH descriptor: [Vitamin K] explode all trees and with qualifier(s): 129 [Antagonists & inhibitors - AI] #51 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or 21 "antivitamin K"):ti,ab,kw in Cochrane Reviews (Reviews and Protocols)

#52 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or 94 "antivitamin K") in Other Reviews, Technology Assessments and Economic Evaluations #53 [mh ^Warfarin] 1355 #54 [mh ^4-hydroxycoumarins] 17 #55 [mh ^acenocoumarol] 111 #56 [mh ^coumarins] 146 #57 [mh ^dicumarol] 22 #58 [mh ^"ethyl biscoumacetate"] 2 #59 [mh ^phenindione] 27 #60 [mh ^phenprocoumon] 87 #61 [mh ^coumafos] 0 #62 (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or 38 dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #63 (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or 474 dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin) in Other Reviews, Technology Assessments and Economic Evaluations #64 (((new or novel) near/2 oral anticoagulant*) or NOAC):ti,ab,kw in Cochrane 9 Reviews (Reviews and Protocols) #65 (((new or novel) near/2 oral anticoagulant*) or NOAC) in Other Reviews, 61 Technology Assessments and Economic Evaluations #66 [mh ^Dabigatran] 90 #67 [mh ^Rivaroxaban] 133 #68 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or 17 rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #69 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or 217 rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana or savaysa or "du

176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E) in Other Reviews, Technology Assessments and Economic Evaluations #70 {or #1-#21} 9717 #71 {or #22-#27} 5306 #72 {or #28-#69} 10274 #73 #70 and #71 and #72 484 #74 #70 and #71 and #72 Publication Year from 2014 to 2016, in Cochrane 22 Reviews (Reviews and Protocols), Other Reviews, Methods Studies, Technology Assessments and Economic Evaluations

Database: CINAHL via EBSCOhost Dato: 27.05.2016 Antall treff: 26

S30 S23 AND S28 Limiters - Published Date: 20140101-20161231 26

S29 S23 AND S28 213

S28 S24 OR S25 OR S26 OR S27 186,502

TI (((systematic* or literature) N2 review*) ) OR AB (((systematic* or literature) N2 S27 61,727 review*) )

S26 TI ( (metaanalys* or meta analys*) ) OR AB ( (metaanalys* or meta analys*) ) 18,128

S25 PT systematic review OR PT review OR PT meta analysis 147,200

S24 (MH "Systematic Review") OR (MH "Literature Review") OR (MH "Meta Analysis") 40,255

S23 S6 AND S10 AND S22 1,089

S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S22 22,598 S20 OR S21

TI ( (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E) ) OR AB ( S21 1,196 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E) )

TI ( (((new or novel) N1 oral anticoagulant*) or NOAC) ) OR AB ( (((new or novel) S20 338 N1 oral anticoagulant*) or NOAC) )

TI ( (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or S19 warfilone or warnerin) ) OR AB ( (coumarin* or cumarin* or phenprocoum* or 3,579 phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin) )

TI ( ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or S18 "antivitamin K") ) OR AB ( ("vitamin K antagonist*" or "vitamink antagonist*" or 363 VKA or VKAs or "antivitamin K") )

TI ( ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") N1 inhibit*) or xabans) ) S17 OR AB ( ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or 420 "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") N1 inhibit*) or xabans) )

TI ( (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*) ) OR AB ( (heparin* or lmwh* or S16 5,111 enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*) )

TI ( (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) ) OR AB ( S15 769 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) )

TI ( (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or S14 AZD0837 or bothrojaracin or odiparcil) ) OR AB ( (argatroban or MD805 or MD- 1,109 805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil) )

S13 TI ( (anticoagul* or antithromb*) ) OR AB ( (anticoagul* or antithromb*) ) 7,876

TI ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" S12 1,802 or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) ) OR AB ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or

grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) )

(MH "Fibrin") OR (MH "Fibrin Fibrinogen Degradation Products") OR (MH "Thrombin/AI") OR (MH "Ticlopidine") OR (MH "Clopidogrel Bisulfate") OR (MH "Anticoagulants+") OR (MH "Blood Coagulation/DE") OR (MH "Blood Coagulation S11 16,985 Factors/AI") OR (MH "Heparin") OR (MH "Heparin, Low-Molecular-Weight") OR (MH "Heparinoids") OR (MH "Warfarin") OR (MH "Vitamin K/AI") OR (MH "Dabigatran Etexilate") OR (MH "Rivaroxaban")

S10 S7 OR S8 OR S9 8,296

TI ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) ) OR S9 328 AB ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) )

TI ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) S8 ) OR AB ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum 5,204 acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) )

S7 (MH "Aspirin") 6,330

S6 S1 OR S2 OR S3 OR S4 OR S5 59,292

TI ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or S5 ischaemia#))) ) OR AB ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or 2,683 seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or ischaemia#))) )

S4 (MH "Cerebral Ischemia, Transient") 2,564

TI ( ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) N4 (isch#emi* or infarct* or thrombo* or emboli*)) ) OR AB ( S3 7,416 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) N4 (isch#emi* or infarct* or thrombo* or emboli*)) )

TI ( (stroke or cerebrovasc* or cerebral vasc*) ) OR AB ( (stroke or cerebrovasc* S2 44,592 or cerebral vasc*) )

(MH "Stroke") OR (MH "Cerebral Ischemia") OR (MH "Dementia, Multi-Infarct") OR (MH "Stroke, Lacunar") OR (MH "Carotid Artery Dissections") OR (MH "Carotid Artery Thrombosis") OR (MH "Intracranial Embolism") OR (MH S1 40,139 "Intracranial Embolism and Thrombosis") OR (MH "Intracranial Thrombosis") OR (MH "Vertebral Artery Dissections") OR (MH "Cerebral Arterial Diseases") OR (MH "Arterial Dissections")

Database: Epistemonikos Dato: 27.05.2016 Antall treff: 39 (1 Broad Synthesis, 38 Systematic Review)

((stroke OR cerebrovasc* OR TIA or TIAs or "ischemic attack" or "ischaemic attack" or "ischemic seizure" or "ischaemic seizure") OR ((brain* OR cerebr* OR cerebell* OR vertebrobasilar OR hemispher* OR intracran* OR intracerebral OR infratentorial OR supratentorial OR MCA OR anterior circulation OR posterior circulation OR basal ganglia OR penumbra) AND (ischemia OR ischaemia OR infarct* OR thrombo* OR emboli*))) AND (aspirin or acetylsalicyl*) AND (clopidogrel* or anticoagul* or antithromb* or heparin or "Vitamin K" or "antivitamin K" or acenocoumarol or coumarin* or dicumarol or "ethyl biscoumacetate" or phenindione or phenprocoumon or coumafos or warfarin or dabigatran or rivaroxaban)