DOCSLIB.ORG

9719087.Pdf (3.190Mb)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
9719087.Pdf (3.190Mb) US009719087B2 a2) United States Patent (0) Patent No.: US 9,719,087 B2 Olson et al. (45) Date of Patent: *Aug. 1, 2017 (54) MICRO-RNA FAMILY THAT MODULATES A61LK 39/3955 (2013.01); AGLK 45/06 FIBROSIS AND USES THEREOF (2013.01); A6IL 31/08 (2013.01); AGIL 31/16 (2013.01); C12N 9/16 (2013.01); C12N (71) Applicant: THE BOARD OF REGENTS, THE 15/8509 (2013.01); AOIK 2207/30 (2013.01); UNIVERSITY OF TEXAS SYSTEM, AOIK 2217/052 (2013.01); AOLK 2217/075 Austin, TX (US) (2013.01); AOIK 2217/15 (2013.01); AOIK 2217/206 (2013.01); AOIK 2227/105 (72) Inventors: Erie N. Olson, Dallas, TX (US); Eva (2013.01); AOIK 2267/0375 (2013.01); AIL van Rooij, Utrecht (NL) 2300/258 (2013.01); A6IL 2300/45 (2013.01); : AOIL 2420/06 (2013.01); C12N 2310/113 (73) Assignee: THE BOARD OF REGENTS, THE (2013.01); CI2N 2310/141 (2013.01); CI2N UNIVERSITY OF TEXAS SYSTEM, 2310/315 (2013.01); C12N 2310/321 Austin, TX (US) (2013.01); C12N 2310/346 (2013.01); C12N (*) Notice: Subjectto any disclaimer, the termbe this (013.01ars orb01301CDN US.C.patent154(b)is extendedby 0 ordays.adjusted under 2320/32 (2013.01);4 . CI2N 2330/10yor(2013.01) (58) Field of Classification Search This patent is subject to a terminal dis- CPC vieceeceseeseeeeeeee C12N 15/113; C12N 2310/141 claimer. See application file for complete search history. — (21) Appl. No.: 14/592,699 (56) References Cited (22) Filed: Jan. 8, 2015 U.S. PATENT DOCUMENTS (65) Prior Publication Data 7,232,806 B2 6/2007 Tuschlet al. US 2016/0145608 Al May 26, 2016 7,674,617 B2 3/2010 Kim etal. 8,440,636 B2* 5/2013 Olson wu... AOIK 67/0276 Related U.S. Application Data 514/44 A 8,940,711 B2 1/2015 Olsonet al. (60) Division of application No. 13/840,823, filed on Mar. 8,940,712 B2 1/2015 Olsonetal. 15, 2013, now Pat. No. 8,940,712, which is a (Continued) continuation of application No. 12/671,445, filed as application No. PCT/US2008/071839 on Jul. 31, FOREIGN PATENT DOCUMENTS 2008, now Pat. No. 8,440,636. EP 1440981 42 7/2004 (60) Provisional application No. 61/047,014,filed on Apr. EP 1627925 Al 2/2006 22, 2008, provisional application No. 60/980,303, (Continued) filed on Oct. 16, 2007, provisional application No. 60/952,917, filed on Jul. 31, 2007. OTHER PUBLICATIONS (51) Int. Cl. Van Rooij et al. “Control of Stress-Dependent Cardiac Growth and CIQN 15/113 (2010.01) Gene Expression by a MicroRNA”, Science, Apr. 27, 2007, vol. AOIK 67/027 (2006.01) 316, Issue 5824, p. 575-579. AGIK 38/22 (2006.01) (Continued) CI2N Y16 (2006.01) CI2N 15/85 (2006.01) AGIK 31/7105 (2006.01) Primary Examiner — J. E. Angell AGIK 31/712 (2006.01) AGIK 31/7125 (2006.01) AGIK 31/713 (2006.01) 6) ABSTRACT A6IK 39/395 (2006.01) The present invention relates to the identification of a AGIK 45/06 (2006.01) microRNA family, designated miR-29a-c, that is a key A6IK 31/07 (2006.01) regulator of fibrosis in cardiac tissue. The inventors show AGIK 31/355 (2006.01) that members of the miR-29 family are down-regulated in A6IK 31/375 (2006.01) the heart tissue in responseto stress, and are up-regulated in AGIL 31/08 (2006.01) heart tissue of mice that are resistant to both stress and AGIL 31/16 (2006.01) fibrosis. Also provided are methods of modulating expres- (52) U.S. Cl. sion and activity of the miR-29 family of miRNAs as a CPC we CI2N 15/113 (2013.01); AOLK 67/0276 treatmentfor fibrotic disease, including cardiac hypertrophy, (2013.01); A61K 31/07 (2013.01); A6IK skeletal muscle fibrosis other fibrosis related diseases and 31/355 (2013.01); A6IK 31/375 (2013.01); collagen loss-related disease. AGIK 31/712 (2013.01); A6IK 31/713 (2013.01); A61K 31/7105 (2013.01); A6IK 31/7125 (2013.01); A6LK 38/2242 (2013.01); 22 Claims, 29 Drawing Sheets US 9,719,087 B2 Page 2 (56) References Cited WO WO 2007/081720 A2 7/2007 WO WO 2007/081740 A2 7/2007 U.S. PATENT DOCUMENTS WO WO 2007/109236 A2 9/2007 WO WO 2007/112754 A2 10/2007 — 8,940,713 B2 1/2015 Olson et al. WO WO 2008/016924 A2 2/2008 9,376,681 B2 6/2016 Montgomery etal. WO WO 2008/043521 A2 4/2008 2005/0059005 Al 3/2005 Tuschl etal. WO WO 2008/061537 A2 5/2008 2005/0222399 Al 10/2005 Bentwich WO WO 2008/116267 Al 10/2008 — 2005/0261218 Al 11/2005 Esau etal. WO WO 2008/147839 Al 12/2008 — 2006/00 19286 Al 1/2006 Horvitz et al. WO WO 2009/012263 A2 1/2009 2006/0063730 Al 3/2006 Moniaetal. WO WO 2009/026576 Al 2/2009 2006/0105360 Al 5/2006 Croceet al. WO WO 2009/043353 A2 4/2009 2006/0185027 Al 8/2006 Bartel et al. WO WO 2009/058818 A2 5/2009 2006/0247 193 Al 11/2006 Taira et al. WO WO 2009/062169 A2 5/2009 2007/0087335 Al 4/2007 Brahmachariet al. WO WO 2009/111375 A2 9/2009 2007/0092882 Al 4/2007 Wangetal. WO WO 2009/114681 A2 9/2009 2008/0050722 Al 2/2008 Kim etal. WO WO 2009/121031 Al 10/2009 — 2008/0176766 Al 7/2008 Brownetal. WO WO 2009/149182 Al 12/2009 — 2009/0053718 Al 2/2009 Naguibnevaet al. WO WO 2010/036939 A2 4/2010 2009/0092980 Al 4/2009 Arenzet al. WO WO 2010/048585 A2 4/2010 2009/0143326 Al 6/2009 Obadetal. 2009/028 1167 Al 11/2009 Shenetal. OTHER PUBLICATIONS 2009/0286969 Al 11/2009 Esau etal. 2009/029 1906 Al 11/2009 Esau etal. Chenget al., “MicroRNAs Are Aberrantly Expressed. in Hypertro- 2009/029 1907 Al 11/2009 Esau etal. phic Heart,” Am. J. Pathol. 170(6):1831-1840 (2007). 2009/0293 148 Al 11/2009 Ren etal. Kim, “International Search Report,” 4 pages, from International 2009/03 17369 Al 12/2009 Hosodaetal. Patent Appl. No. PCT/US2008/071839, Korean Intellectual Prop- 2009/0326049 Al 12/2009 Aristarkhovetal. 2010/0029003 Al 2/2010 Bartel et al. erty Office, Daejon, Republic of Korea (mailed Jan. 6, 2009). Rooij et al., “A signature pattern of stress-responsive microRNAs 2010/00875 12 4/2010 Tuschl etal. that can evoke cardiac hypertrophy and heart failure,” Proc. Natl. 2010/00875 13 4/2010 Tuschl etal. 2010/0093837 4/2010 Tuschl etal. Acad. Sci. USA 103(48): 18255-18260 (2006). 2010/0099748 4/2010 Tuschl etal. Tatsuguchi et al., “Expression of MicroRNAs is Dynamically 2010/0113561 5/2010 Tuschl etal. Regulated During Cardiomyocyte Hypertrophy,” J. Mol. Cell. 2016/0145607 5/2016 Olson et al. Cardiol. 42(6):1137-1141 (2007). 2016/0145609 5/2016 Olson et al. Lagos-Quintanaet al., “New microRNAsfrom mouse and human,” 2016/0355815 12/2016 Montgomery etal. RNA,vol. 9:175-179, 2003. Lagos-Quintanaet al., “Identification of tissue-specific microRNAs FOREIGN PATENT DOCUMENTS from mouse,” Current Biology, vol. 12:735-739, 2002. Sempere et al., “Expression profiling of mammalian microRNAs EP 1777301 A2 4/2007 uncovers a subset of brain-expressed microRNAs with possible EP 1959012 A2 8/2008 roles in murine and human neuronal differentiation,” Genome EP 2113567 Al 11/2009 Biology, vol. 5:R13, 2004. JP 2006-5 19008 8/2006 Mott et al., “miR-29 regulates Mcl-1 protein expression and. JP 2006-292367 10/2006 apoptosis,” Oncogene, vol. 26: 6133-6140, 2007. WO WO 03/029459 A2 4/2003 Heet al., “Overexpression of Micro Ribonucleic Acid 29, Highly WO WO 2004/076622 A2 9/2004 Up-Regulated in Diabetic Rats, Leads to Insulin Resistance in WO WO 2005/013901 A2 2/2005 3T3-L1 Adipocytes,” Molecular Endocrinology, vol. 21: 2785- WO WO 2005/017145 Al 2/2005 2794, 2007. WO WO 2005/040419 Al 5/2005 Zhaoet al., “Dysregulation of Cardiogenesis, Cardiac Conduction, WO WO 2005/047505 A2 5/2005 WO WO 2005/056797 Al 6/2005 and Cell Cycle in Mice Lacking miRNA-1-2,” Cell, vol. 129: WO WO 2005/118806 A2 12/2005 303-317, 2007. WO WO 2006/033020 A2 3/2006 Van Rooij et al., “Dysregulation of microRNAsafter myocardial WO WO 2006/033928 A2 3/2006 infarction reveals a role of miR-29 in cardiac fibrosis,” Proc. Natl. WO WO 2006/081284 A2 8/2006 Acad. Sci. USA, vol. 105: 13027-13032, 2008. WO WO 2006/108473 Al 10/2006 Spindler, Supplementary European Search Report for European WO WO2006/111512 Al 10/2006 Application No. 08797006.7, 10 pages, European Patent Office, The WO WO 2006/128245 Al 12/2006 Hague, mailed Aug. 17, 2011. WO WO 2006/133022 A2 12/2006 Pekarsky Y. et al., “Tell expression in chronic lymphocytic leukemia WO WO 2006/137941 A2 12/2006 is regulated by miR-29 and miR-181,” Cancer Research, vol. WO WO 2007/000668 A2 1/2007 66:11590-11593, 2006. WO WO 2007/016548 A2 2/2007 WO WO 2007/033023 A2 3/2007 Written Opinion of the International Searching Authority mailed on WO WO 2007/042899 A2 4/2007 Jan. 6, 2009, for PCT Application No. PCT/US2008/071839, filed. WO WO 2007/067695 A2 6/2007 on Jul. 31, 2008, 5 pages. WO WO 2007/070483 A2 6/2007 WO WO 2007/081680 A2 7/2007 * cited by examiner B2 9,719,087 US t “Sig if DONNODYVYWWOSYpOVOTEAY JS QOS-HIW GIMBW (s :oN ar a5) 1.2 wou ¥ a.
Load more

Recommended publications
  • (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao Et Al
    USOO9498481 B2 (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao et al. (45) Date of Patent: *Nov. 22, 2016 (54) CYCLOPROPYL MODULATORS OF P2Y12 WO WO95/26325 10, 1995 RECEPTOR WO WO99/O5142 2, 1999 WO WOOO/34283 6, 2000 WO WO O1/92262 12/2001 (71) Applicant: Apharaceuticals. Inc., La WO WO O1/922.63 12/2001 olla, CA (US) WO WO 2011/O17108 2, 2011 (72) Inventors: Tadimeti Rao, San Diego, CA (US); Chengzhi Zhang, San Diego, CA (US) OTHER PUBLICATIONS Drugs of the Future 32(10), 845-853 (2007).* (73) Assignee: Auspex Pharmaceuticals, Inc., LaJolla, Tantry et al. in Expert Opin. Invest. Drugs (2007) 16(2):225-229.* CA (US) Wallentin et al. in the New England Journal of Medicine, 361 (11), 1045-1057 (2009).* (*) Notice: Subject to any disclaimer, the term of this Husted et al. in The European Heart Journal 27, 1038-1047 (2006).* patent is extended or adjusted under 35 Auspex in www.businesswire.com/news/home/20081023005201/ U.S.C. 154(b) by Od en/Auspex-Pharmaceuticals-Announces-Positive-Results-Clinical M YW- (b) by ayS. Study (published: Oct. 23, 2008).* This patent is Subject to a terminal dis- Concert In www.concertpharma. com/news/ claimer ConcertPresentsPreclinicalResultsNAMS.htm (published: Sep. 25. 2008).* Concert2 in Expert Rev. Anti Infect. Ther. 6(6), 782 (2008).* (21) Appl. No.: 14/977,056 Springthorpe et al. in Bioorganic & Medicinal Chemistry Letters 17. 6013-6018 (2007).* (22) Filed: Dec. 21, 2015 Leis et al. in Current Organic Chemistry 2, 131-144 (1998).* Angiolillo et al., Pharmacology of emerging novel platelet inhibi (65) Prior Publication Data tors, American Heart Journal, 2008, 156(2) Supp.
    [Show full text]
  • Asymmetric Organocatalyzed Synthesis of Coumarin Derivatives
    Asymmetric organocatalyzed synthesis of coumarin derivatives Natália M. Moreira‡, Lorena S. R. Martelli‡ and Arlene G. Corrêa* Review Open Access Address: Beilstein J. Org. Chem. 2021, 17, 1952–1980. Centre of Excellence for Research in Sustainable Chemistry, https://doi.org/10.3762/bjoc.17.128 Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP – Brazil Received: 08 March 2021 Accepted: 21 July 2021 Email: Published: 03 August 2021 Arlene G. Corrêa* - [email protected] This article is part of the thematic issue "New advances in asymmetric * Corresponding author ‡ Equal contributors organocatalysis". Keywords: Guest Editor: R. Šebesta asymmetric synthesis; green chemistry; 2H-chromen-2-one; organocatalysis © 2021 Moreira et al.; licensee Beilstein-Institut. License and terms: see end of document. Abstract Coumarin derivatives are essential scaffolds in medicinal and synthetic chemistry. Compounds of this class have shown important activities, such as anticancer and antiparasitic, besides the commercially available drugs. These properties led to the development of efficient and greener synthetic methods to achieve the 2H-chromen-2-one core. In this context, the advances in asymmetric organocatalyzed synthesis of coumarin derivatives are discussed in this review, according to the mode of activation of the catalyst. Introduction Coumarins are important naturally occurring plant constituents and display a wide range of pharmacological and biological ac- tivities, such as anticancer [1], antibacterial [2], and
    [Show full text]
  • Characterising the Risk of Major Bleeding in Patients With
    EU PE&PV Research Network under the Framework Service Contract (nr. EMA/2015/27/PH) Study Protocol Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU Version 3.0 1 June 2018 EU PAS Register No: 16014 EMA/2015/27/PH EUPAS16014 Version 3.0 1 June 2018 1 TABLE OF CONTENTS 1 Title ........................................................................................................................................... 5 2 Marketing authorization holder ................................................................................................. 5 3 Responsible parties ................................................................................................................... 5 4 Abstract ..................................................................................................................................... 6 5 Amendments and updates ......................................................................................................... 7 6 Milestones ................................................................................................................................. 8 7 Rationale and background ......................................................................................................... 9 8 Research question and objectives .............................................................................................. 9 9 Research methods ....................................................................................................................
    [Show full text]
  • Reactivity and Alkylating Potential of Some O-Heterocycles
    Dpto. de Qu´ımica f´ısica Facultad de Ciencias Qu´ımicas PhD Thesis Chemical processes that can damage cellular DNA: Reactivity and alkylating potential of some O-heterocycles Supervisors: Author: Prf. Dr. Julio Casado Rafael Gomez´ Bombarelli Prf. Dr. Emilio Calle November 8, 2011 A Marta, Jose,´ Lali y Pepe en ningun´ orden en particular Departamento de Qu´ımica f´ısica Facultad de Ciencias Qu´ımicas The work reported here has been carried out in the Departamento de Qu´ımica f´ısica of the Universidad de Salamanca, under the advice of Prof. Dr. Julio Casado Linarejos and Prof. Dr. Emilio Calle Mart´ın. Rafael Gomez´ Bombarelli Emilio Calle Mart´ın Julio Casado Linarejos It’s been emotional. Big Chris Acknowledgements The author thanks the Spanish Ministerio de Educacion´ for a PhD fellowship (AP2006-01976) and financed research stays at the workgroups of Prof. Dr. Jose´ Rueff (Universidade Nova de Lisboa) and Prof. Dr. Franc¸ois Maurel (ITODYS, Paris-VII), who are also thanked for their hos- pitality. Financial support of the research reported in this work by the Ministerio de Ciencia e Innovacion´ (projects CTQ2010-18999, CTQ2007-63263, CTQ2004-05048), and the Junta de Castilla y Leon´ and European Regional Development Fund (project SA040A08) is also ac- knowledged. E. Bombarelli and J. Arenas are also thanked for their generous donation of CPU-time and resources. i Contents List of Figuresv List of Tables vii List of Schemes ix Abbreviations xi Preface xiii 1 Alkylating agents and the NBP Test: a review 1 1.1 Development of the method....................5 1.1.1 Early examples.......................5 1.1.2 The Epstein test.......................6 1.1.3 Biological samples......................7 1.1.4 Chromatography......................7 1.2 NBP as a DNA-model.......................8 1.2.1 Nucleophilicity of DNA....................8 1.2.2 Site selectivity......................
    [Show full text]
  • The In¯Uence of Medication on Erectile Function
    International Journal of Impotence Research (1997) 9, 17±26 ß 1997 Stockton Press All rights reserved 0955-9930/97 $12.00 The in¯uence of medication on erectile function W Meinhardt1, RF Kropman2, P Vermeij3, AAB Lycklama aÁ Nijeholt4 and J Zwartendijk4 1Department of Urology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; 2Department of Urology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands; 3Pharmacy; and 4Department of Urology, Leiden University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands Keywords: impotence; side-effect; antipsychotic; antihypertensive; physiology; erectile function Introduction stopped their antihypertensive treatment over a ®ve year period, because of side-effects on sexual function.5 In the drug registration procedures sexual Several physiological mechanisms are involved in function is not a major issue. This means that erectile function. A negative in¯uence of prescrip- knowledge of the problem is mainly dependent on tion-drugs on these mechanisms will not always case reports and the lists from side effect registries.6±8 come to the attention of the clinician, whereas a Another way of looking at the problem is drug causing priapism will rarely escape the atten- combining available data on mechanisms of action tion. of drugs with the knowledge of the physiological When erectile function is in¯uenced in a negative mechanisms involved in erectile function. The way compensation may occur. For example, age- advantage of this approach is that remedies may related penile sensory disorders may be compen- evolve from it. sated for by extra stimulation.1 Diminished in¯ux of In this paper we will discuss the subject in the blood will lead to a slower onset of the erection, but following order: may be accepted.
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin Et Al
    US 201201.15729A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin et al. (43) Pub. Date: May 10, 2012 (54) PROCESS FOR FORMING FILMS, FIBERS, Publication Classification AND BEADS FROM CHITNOUS BOMASS (51) Int. Cl (75) Inventors: Ying Qin, Tuscaloosa, AL (US); AOIN 25/00 (2006.01) Robin D. Rogers, Tuscaloosa, AL A6II 47/36 (2006.01) AL(US); (US) Daniel T. Daly, Tuscaloosa, tish 9.8 (2006.01)C (52) U.S. Cl. ............ 504/358:536/20: 514/777; 426/658 (73) Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF 57 ABSTRACT ALABAMA, Tuscaloosa, AL (US) (57) Disclosed is a process for forming films, fibers, and beads (21) Appl. No.: 13/375,245 comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process (22) PCT Filed: Jun. 1, 2010 can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, (86). PCT No.: PCT/US 10/36904 or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally S3712). (4) (c)(1), Date: Jan. 26, 2012 occurring and/or synthetic polymer. Disclosed herein are the (2), (4) Date: an. AO. films, fibers, and beads obtained from the disclosed process. O O This Abstract is presented solely to aid in searching the sub Related U.S. Application Data ject matter disclosed herein and is not intended to define, (60)60) Provisional applicationpp No. 61/182,833,sy- - - s filed on Jun.
    [Show full text]
  • Cardiovascular Disease Dyslipidemia | Non-Pharmacologic Treatment |
    Cardiovascular Disease Dyslipidemia: Non-Pharmacologic Treatment Mark C. Houston, M.D., M.S. ABAARM, FACP, FACN, FAHA, FASH INTRODUCTION Cardiovascular disease (CVD) is the number one cause of morbidity and mortality in the United States,1 coronary heart disease (CHD) and myocardial infarction being the leading causes of death.1 The five major risk factors for CHD – hypertension, dyslipidemia, diabetes mellitus, smoking, and obesity – account for 80% of the risk for CHD.1,2 Interventions, both pharmacologic and nonpharmacologic, can improve all of these risk factors and decrease the incidence of CVD and its consequences, such as 3-6 myocardial infarction, angina, congestive heart failure and stroke. Recent guidelines by the National Cholesterol Education Program (NCEP) recommend more aggressive control of serum lipids to reduce the incidence of CHD.7 Nutritional and dietary therapy, weight loss, exercise, and scientifically-proven nutritional supplementation should be used initially in appropriately selected patients to manage dyslipidemia. Hypertriglyceridemia, which is frequently due to obesity, insulin resistance, metabolic syndrome and diabetes mellitus, deserves special attention.7 Pharmacologic therapy should be administered in those cases that are at high or very high-risk for CHD and those who do not respond to non-drug therapy. Many patients prefer non-drug therapies for many reasons including adverse effects of anti-lipid drugs, contraindications or allergic reactions to drugs, perceptions of adverse effects of drugs, or personal preference for natural or alternative therapies. A more aggressive integrative approach to the management of dyslipidemia is recommended to improve CHD outcomes, minimize adverse effects, and reduce health-care costs. NUTRITION AND EXERCISE Optimal nutrition and proper aerobic and resistance exercise form the cornerstone for the management of dyslipidemia.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
    [Show full text]
  • Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy with Hospitalization for Upper Gastrointestinal Tract Bleeding
    Supplementary Online Content Ray WA, Chung CP, Murray KT, et al. Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding. JAMA. doi:10.1001/jama.2018.17242 eAppendix. PPI Co-therapy and Anticoagulant-Related UGI Bleeds This supplementary material has been provided by the authors to give readers additional information about their work. Downloaded From: https://jamanetwork.com/ on 10/02/2021 Appendix: PPI Co-therapy and Anticoagulant-Related UGI Bleeds Table 1A Exclusions: end-stage renal disease Diagnosis or procedure code for dialysis or end-stage renal disease outside of the hospital 28521 – anemia in ckd 5855 – Stage V , ckd 5856 – end stage renal disease V451 – Renal dialysis status V560 – Extracorporeal dialysis V561 – fitting & adjustment of extracorporeal dialysis catheter 99673 – complications due to renal dialysis CPT-4 Procedure Codes 36825 arteriovenous fistula autogenous gr 36830 creation of arteriovenous fistula; 36831 thrombectomy, arteriovenous fistula without revision, autogenous or 36832 revision of an arteriovenous fistula, with or without thrombectomy, 36833 revision, arteriovenous fistula; with thrombectomy, autogenous or nonaut 36834 plastic repair of arteriovenous aneurysm (separate procedure) 36835 insertion of thomas shunt 36838 distal revascularization & interval ligation, upper extremity 36840 insertion mandril 36845 anastomosis mandril 36860 cannula declotting; 36861 cannula declotting; 36870 thrombectomy, percutaneous, arteriovenous
    [Show full text]