Acetylsalisylsyre, clopidogrel og antikoagulasjon – PICO 1.4 Kontaktperson: Liv Hege Kateraas og Bent Indredavik Søk: Marita Heintz Kommentar: Søk etter systematiske oversikter Tidsbruk: 25 timer Pico-skjema: Spørsmålet i PICO format Hva handler spørsmålet om? Comparison Populasjon Outcome(s) Intervensjon (tiltak) (sammenligning/ (pasient) (utfall/effekt) kontroll) Har pasienter med TIA/ TIA/ akutt hjerneinfarkt Tillegg av clopidogrel Hjerneinfarkt / pasienter som bruker eller antikoagulasjon vaskulære aktutt hjerneinfarkt acetylsalicylsyre hendelser / død som bruker acetylsalisylsyre, effekt av clopidogrel eller antikoagulasjon i tillegg? Database: Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Dato: 27.05.2016 Antall treff: 191 (186 etter sletting av interne dubletter) stroke/ or cerebral infarction/ or dementia, multi-infarct/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or stroke, lacunar/ or brain 1 ischemia/ or carotid artery, internal, dissection/ or carotid artery thrombosis/ or "intracranial 136566 embolism and thrombosis"/ or intracranial embolism/ or intracranial thrombosis/ or vertebral artery dissection/ 2 (stroke or cerebrovasc* or cerebral vasc*).tw. 212662 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or 84829 infarct* or thrombo* or emboli*)).tw. 4 Ischemic Attack, Transient/ 18590 (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or 5 16514 brain or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw. 6 or/1-5 304555 7 Aspirin/ or Aspirin, Dipyridamole Drug Combination/ 40351 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or 58721 asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or 9 acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or 9560 acetylosalicylic or acetylsalicyclic) adj1 acid).mp. 10 or/7-9 61478 11 Ticlopidine/aa [Analogs & Derivatives] 7203 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 12 33931 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp. 13 exp anticoagulants/ 192004 14 exp Blood Coagulation/ai, de [Antagonists & Inhibitors, Drug Effects] 17407 15 exp Blood Coagulation Factors/ai [Antagonists & Inhibitors] 14008 16 (anticoagul* or antithromb*).tw. 93566 17 exp antithrombins/ 17816 18 hirudin therapy/ 637 19 thrombin/ai [Antagonists & Inhibitors] 3500 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or 20 flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin$ or desirudin or 9909 desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp. (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or 21 4851 edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp. 22 heparin/ 51329 23 exp heparin, low-molecular-weight/ 10694 24 heparinoids/ 921 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or 25 tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or 132454 danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp. 26 Factor Xa Inhibitors/ 2826 ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or "autoprothrombin c" or thrombokinase or 27 6106 "activated factor X" or "factor 10") adj2 inhibit*) or xabans).mp. 28 exp Vitamin K/ai [Antagonists & Inhibitors] 1969 29 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw. 3576 Warfarin/ or 4-hydroxycoumarins/ or acenocoumarol/ or coumarins/ or dicumarol/ or ethyl 30 32541 biscoumacetate/ or phenindione/ or phenprocoumon/ or coumafos/ (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or 31 46091 adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin).mp. 32 (((new or novel) adj2 oral anticoagulant*) or NOAC).tw. 2110 33 Dabigatran/ or Rivaroxaban/ 2438 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY 59 7939" or "BAY 597939" or "BAY59 7939" or BAY597939 or apixaban or "bms 562247" or bms562247 or eliques or eliquis or edoxaban or lixiana 34 6391 or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY517717 or darexaban or SSR126517E).mp. 35 or/11-34 356193 36 6 and 10 and 35 5452 37 ((systematic* or literature) adj2 review*).mp. 197770 38 (metaanalys* or meta analys*).mp. or (meta analysis or review).pt. 2190404 39 37 or 38 2254220 40 36 and 39 1822 41 limit 40 to yr="2014 -Current" 191 Database: Embase 1974 to 2016 May 26 Dato: 27.05.2016 Antall treff: 247 (235 etter sletting av interne dubletter) cerebrovascular accident/ or brain infarction/ or multiinfarct dementia/ or cerebral artery disease/ or 1 lacunar stroke/ or brain ischemia/ or carotid artery injury/ or carotid artery thrombosis/ or brain 261586 embolism/ or occlusive cerebrovascular disease/ or artery dissection/ 2 (stroke or cerebrovasc* or cerebral vasc*).tw. 310963 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or infarct* 115416 or thrombo* or emboli*)).tw. 4 transient ischemic attack/ 29162 (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain 5 26044 or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw. 6 or/1-5 469116 7 acetylsalicylic acid/ or acetylsalicylic acid plus dipyridamole/ 177684 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or 103758 asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or 9 acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or 179662 acetylosalicylic or acetylsalicyclic) adj1 acid).mp. 10 or/7-9 187544 11 clopidogrel/ 44865 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 12 46847 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp. exp anticoagulant agent/ or anticoagulant therapy/ or exp thrombin inhibitor/ or exp blood clotting 13 571957 factor 10a inhibitor/ or 4 hydroxycoumarin/ or coumarin/ or coumarin derivative/ 14 (anticoagul* or antithromb*).tw. 132351 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or 15 flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin$ or desirudin or 23701 desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp. (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY517717 or darexaban or 16 14528 edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp. (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or 17 230987 danaparoid or lomoparan or org 10172 or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp. ((("direct thrombin" or "factor xa" or "factor 10a" or fXa or "autoprothrombin c" or thrombokinase or 18 8494 "activated factor X" or "factor 10") adj2 inhibit*) or xabans).mp. 19 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw. 6038 (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione 20 or marevan or warfarin* or