Supplemental Table S1. comprising the DNA replication, recombination and repair biological function whose radiation-induced up-regulation was inhibited by INK128

Symbol Name AKAP8L A kinase (PRKA) anchor 8-like ALKBH1 alkB, alkylation repair homolog 1 (E. coli) AMPD3 adenosine monophosphate deaminase 3 APTX aprataxin ARL8B ADP-ribosylation factor-like 8B BECN1 beclin 1, autophagy related BRCA2 breast cancer 2, early onset BRE brain and reproductive organ-expressed (TNFRSF1A modulator) BSG basigin (Ok blood group) CALR calreticulin CASP2 caspase 2, apoptosis-related cysteine peptidase CASP6 caspase 6, apoptosis-related cysteine peptidase CCNA2 cyclin A2 CD40 CD40 molecule, TNF receptor superfamily member 5 CEP120 centrosomal protein 120kDa CHMP1B charged multivesicular body protein 1B CSNK1G1 casein kinase 1, gamma 1 CUL1 cullin 1 DDB1 damage-specific DNA binding protein 1, 127kDa DFFA DNA fragmentation factor, 45kDa, alpha polypeptide DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 DNASE2 deoxyribonuclease II, lysosomal DSCC1 defective in sister chromatid cohesion 1 homolog (S. cerevisiae) DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 EXOG endo/exonuclease (5'-3'), endonuclease G-like FANCC Fanconi anemia, complementation group C FOXO3 forkhead box O3 FTO fat mass and obesity associated GTPBP4 GTP binding protein 4 HBEGF heparin-binding EGF-like growth factor HJURP Holliday junction recognition protein HMGB1 high mobility group box 1 HUS1 HUS1 checkpoint homolog (S. pombe) KIF23 kinesin family member 23 LEPREL4 leprecan-like 4 LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog MBD2 methyl-CpG binding domain protein 2 MYC v-myc myelocytomatosis viral oncogene homolog (avian)

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NAP1L1 assembly protein 1-like 1 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 ORC5 origin recognition complex, subunit 5 PARG poly (ADP-ribose) glycohydrolase POLG2 polymerase (DNA directed), gamma 2, accessory subunit PRKCZ protein kinase C, zeta RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) RAD17 RAD17 homolog (S. pombe) RAD18 RAD18 homolog (S. cerevisiae) RBBP5 retinoblastoma binding protein 5 RIOK3 RIO kinase 3 SSRP1 structure specific recognition protein 1 SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) TACC3 transforming, acidic coiled-coil containing protein 3 TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TBP TATA box binding protein TLK2 tousled-like kinase 2 UVRAG UV radiation resistance associated VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) WAPAL wings apart-like homolog (Drosophila) XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 XRN2 5'-3' exoribonuclease 2

2