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CURRICULUM VITAE Maria Pia Sormani Birthplace Genoa, Italy CURRICULUM VITAE Maria Pia Sormani Birthplace Genoa, Italy Citizenship Italian Work Address Department of Health Sciences, University of Genoa, Italy Present position Professor of Biostatistics Education/Training 1987-1992 University of Genoa, Italy Degree in Physics Level in national classification : 110/110 cum laude 1994-1996 University of Pisa, Italy Master in Medical Physics; Level in national classification : 50/50 1996-1998 University of Milan, Italy Master in Statistics in Medicine. Level in national classification : 70/70 cum laude Positions and Employment 1992-1993 Postdoctoral Fellow, Department of Biophysics, University of Genoa (Prof Vincent Torre) 1993-1995 Postdoctoral Fellow, Biophysics Unit, National Institute for Cancer Research, Genoa (Prof Luciano Andreucci) 1995-2005 Assistant Researcher, Unit of Clinical Epidemiology, National Institute for Cancer Research, Genoa (Prof Paolo Bruzzi) 1997-2008 Consultant, Neuroimaging Research Unit, Ospedale San Raffaele, Milan (Prof Massimo Filippi) 2005-2014 Researcher, Department of Health Sciences, University of Genoa 2014-Present Professor of Biostatistics, Department of Health Sciences, University of Genoa Other Experience and Professional Memberships Member of the USMS National Society Clinical Trials Committee Member of the MS Outcome Assessment Consortium (MSOAC) Visiting Professor at the Imperial College of London (Prof Paul Matthews) Member of the PMSA Clinical Science Review Committee Member of Steering Commettee and Data and Safety Monitoring Board of clinical trials Chairman and Invited Speaker at International Meetings (ECTRIMS 2008-2015), EAN 2014-2015. Editorial boards Multiple Sclerosis Journal Multiple Sclerosis and Other Demyelinating Diseases Multiple Sclerosis and Related Disorders Ad Hoc Reviewer Lancet Neurology Brain Neurology Journal of Clinical Oncology JNNP European Journal of Neurology Multiple Sclerosis Journal Participation in Grant Review Panels USMS National Society Grants PMSA Grants MS Research Australia 2015 funding UK MS Society 2015 Grant Round Expert assessments of applicants for employment as Professor in Genetic Epidemiology specializing in Multiple Sclerosis at Karolinska Institute 2015 Teaching Record I have been teaching the course of Statistics in Medicine at the faculty of Medicine at the University of Genoa since 2005. I have been teaching the course of Statistics in Medicine in 21 courses for Health Professionals at the faculty of Medicine at the University of Genoa since 2005. I take courses and seminars on research Methodology for the Doctorate School at the University of Genoa since 2005. Advising of undergraduates, graduate student, and postdoctoral fellows. In the past 10 years I have been the primary advisor of 7 postdocs, 4 undergraduate students. I have also served on approximately 10 PhD. Committees. Below is a list of the graduate students that performed their thesis studies in my lab and of the past and present postdoctoral fellows. Alessandra Gennari 2006-2008 Roberto Crocchiolo 2007-2009 Francesco Cardinale 2008-2010 Alessio Signori 2010-2012 Irene Schiavetti 2012-2014 Fabio Gallo 2014-2016 Francesca Bovis 2015-2017 Publications Author and co/author of more than 280 publications on on peer-reviewed journals Impact Factor >1500 H-index=61 Date January 2016 Signature Appendix: List of publications 1. De Stefano N, Stromillo ML, Giorgio A, Bartolozzi ML, Battaglini M, Baldini M,Portaccio E, Amato MP, Sormani MP. Establishing pathological cut-offs of brainatrophy rates in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015 Apr 22. 2. Romeo M, Martinelli V, Rodegher M, Perego E, Maida S, Sormani MP, Comi G; San Raffaele Multiple Sclerosis Clinical Group. Validation of 1-year predictive score of long-term response to interferon-β in everyday clinical practice multiple sclerosis patients. Eur J Neurol. 2015 Jun;22(6):973-80. 3. Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree BA, de Seze J,Flor A, Fujihara K, Greenberg B, Higashi S, Holt W, Khan O, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter S, Villoslada P, Walton MK, Wasiewski W, Wingerchuk DM, Yeaman MR; Guthy-Jackson Charitable Foundation International Clinical Consortium. Challenges and opportunities in designing clinical trials for neuromyelitis optica. Neurology. 2015 Apr 28;84(17):1805-1815. 4. Bignotti B, Signori A, Sormani MP, Molfetta L, Martinoli C, Tagliafico A.Ultrasound versus magnetic resonance imaging for Morton neuroma: systematic review and meta- analysis. Eur Radiol. 2015 Mar 26. [Epub ahead of print] PubMed PMID: 25809742. 5. Signori A, Schiavetti I, Gallo F, Sormani MP. Subgroups of multiple sclerosis patients with larger treatment benefits: a meta-analysis of randomized trials. Eur J Neurol. 2015 Jun;22(6):960-6. doi: 10.1111/ene.12690. 6. Mattoscio M, Nicholas R, Sormani MP, Malik O, Lee JS, Waldman AD, Dazzi F,Muraro PA. Hematopoietic mobilization: Potential biomarker of response tonatalizumab in multiple sclerosis. Neurology. 2015 Mar 11. pii:10.1212/WNL.0000000000001454. [Epub ahead of print] PubMed PMID: 25762712.2: 7. Gennari A, Costa M, Puntoni M, Paleari L, De Censi A, Sormani MP, Provinciali N, Bruzzi P. Breast cancer incidence after hormonal treatments for infertility:systematic review and meta-analysis of population-based studies. Breast CancerRes Treat. 2015 Mar 6. [Epub ahead of print] PubMed PMID: 25744295. 8. Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A,Lugaresi A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, DiGioia M, Vuolo L, Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P,Farge D, Saccardi R; ASTIMS Haemato-Neurological Collaborative Group, On behalfof the Autoimmune Disease Working Party (ADWP) of the European Group for Bloodand Marrow Transplantation (EBMT); ASTIMS Haemato-Neurological CollaborativeGroup On behalf of the Autoimmune Disease Working Party ADWP of the EuropeanGroup for Blood and Marrow Transplantation EBMT. Autologous hematopoietic stemcell transplantation in multiple sclerosis: A phase II trial. Neurology. 2015 Mar10;84(10):981-8. doi: 10.1212/WNL.0000000000001329. Epub 2015 Feb 11. PubMedPMID: 25672923. 9. Sormani M, De Stefano N, Francis G, Sprenger T, Chin P, Radue E, Kappos L.Fingolimod effect on brain volume loss independently contributes to its effect ondisability. Mult Scler. 2015 Feb 6. pii: 1352458515569099. [Epub ahead of print] PubMed PMID: 25662353 10. Federici S, Sormani MP, Ozen S, Lachmann HJ, Amaryan G, Woo P, Koné-Paut I,Dewarrat N, Cantarini L, Insalaco A, Uziel Y, Rigante D, Quartier P, Demirkaya E,Herlin T, Meini A, Fabio G, Kallinich T, Martino S, Butbul AY, Olivieri A,Kuemmerle-Deschner J, Neven B, Simon A, Ozdogan H, Touitou I, Frenkel J, Hofer M,Martini A, Ruperto N, Gattorno M; for the Paediatric Rheumatology InternationalTrials Organisation (PRINTO) and Eurofever Project. Evidence-based provisionalclinical classification criteria for autoinflammatory periodic fevers. Ann Rheum Dis. 2015 Jan 30. pii: annrheumdis-2014- 206580. doi:10.1136/annrheumdis-2014-206580. [Epub ahead of print] Review. PubMed PMID:25637003 11. Curro' D, Vuolo L, Gualandi F, Bacigalupo A, Roccatagliata L, Capello E,Uccelli A, Saccardi R, Sormani MP, Mancardi G. Low intensity lympho-ablativeregimen followed by autologous hematopoietic stem cell transplantation in severe forms of multiple sclerosis: A MRI-based clinical study. Mult Scler. 2015 Jan 12.pii: 1352458514564484. [Epub ahead of print] PubMed PMID: 25583838. 12. Sormani MP, Bruzzi P. Can we measure long-term treatment effects in multiplesclerosis? Nat Rev Neurol. 2015 Mar;11(3):176-182. doi:10.1038/nrneurol.2014.237. Epub 2014 Dec 23. Review. PubMed PMID: 25534913 13. Govindarajan ST, Cohen-Adad J, Sormani MP, Fan AP, Louapre C, Mainero C.Reproducibility of T(2) * mapping in the human cerebral cortex in vivo at 7 teslaMRI. J Magn Reson Imaging. 2014 Nov 19. doi: 10.1002/jmri.24789. [Epub ahead ofprint] PubMed PMID: 25407671 14. Berruti A, Amoroso V, Gallo F, Bertaglia V, Simoncini E, Pedersini R, Ferrari L, Bottini A, Bruzzi P, Sormani MP. Pathologic complete response as a potentialsurrogate for the clinical outcome in patients with breast cancer afterneoadjuvant therapy: a meta- regression of 29 randomized prospective studies. JClin Oncol. 2014 Dec 1;32(34):3883- 91. doi: 10.1200/JCO.2014.55.2836. Epub 2014Oct 27. Review. PubMed PMID: 25349292 15. Pane M, Mazzone ES, Sivo S, Sormani MP, Messina S, D Amico A, Carlesi A, VitaG, Fanelli L, Berardinelli A, Torrente Y, Lanzillotta V, Viggiano E, D AmbrosioP, Cavallaro F, Frosini S, Barp A, Bonfiglio S, Scalise R, De Sanctis R, Rolle E,Graziano A, Magri F, Palermo C, Rossi F, Donati MA, Sacchini M, Arnoldi MT,Baranello G, Mongini T, Pini A, Battini R, Pegoraro E, Previtali S, Bruno C,Politano L, Comi GP, Bertini E, Mercuri E. Long term natural history data inambulant boys with Duchenne muscular dystrophy: 36- month changes. PLoS One. 2014 Oct 1;9(10):e108205. doi: 10.1371/journal.pone.0108205. eCollection 2014. PubMed PMID: 25271887; PubMed Central PMCID: PMC4182715. 16. Sormani MP. Comment on the letter by Messori et al. (European Journal ofNeurology 2013; 20: e131). Eur J Neurol. 2014 Oct;21(10):e84. doi:10.1111/ene.12480. PubMed PMID: 25209064. 17. Crimi G, Ferlini M, Gallo F, Sormani MP, Raineri C, Bramucci E, De FerrariGM, Pica S, Marinoni B, Repetto A, Raisaro A, Leonardi S, Rubartelli P, Visconti LO, Ferrario M. Remote ischemic postconditioning as a strategy to reduce acutekidney injury during primary PCI: a post-hoc analysis of a randomized trial. Int J Cardiol. 2014 Dec 15;177(2):500-2. doi: 10.1016/j.ijcard.2014.08.080. Epub 2014Aug 23. PubMed PMID: 25183541. 18. Clerico M, Schiavetti I, De Mercanti SF, Piazza F, Gned D, Brescia Morra V,Lanzillo R, Ghezzi A, Bianchi A, Salemi G, Realmuto S, Sola P, Vitetta F, CavallaP, Paolicelli D, Trojano M, Sormani MP, Durelli L. Treatment ofrelapsing-remitting multiple sclerosis after 24 doses of natalizumab: evidencefrom an Italian spontaneous, prospective, and observational study (the TY-STOPStudy). JAMA Neurol. 2014 Aug;71(8):954-60. doi: 10.1001/jamaneurol.2014.1200.PubMed PMID: 24977406.
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