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Article Prognosis of CKD Patients Receiving Outpatient Nephrology Care in Italy Luca De Nicola,* Paolo Chiodini,† Carmine Zoccali,‡ Silvio Borrelli,* Bruno Cianciaruso,§ Biagio Di Iorio, Domenico Santoro,¶ Vincenzo Giancaspro,** Cataldo Abaterusso,†† Ciro Gallo,† Giuseppe Conte,* and Roberto Minutolo,* for the SIN-TABLE CKD Study Group‡‡ Summary *Nephrology Division Background and objectives Prognosis in nondialysis chronic kidney disease (CKD) patients under regular and †Unit of Medical nephrology care is rarely investigated. Statistics at the Second University of Naples, Naples, Italy; Design, setting, participants, & measurements We prospectively followed from 2003 to death or June 2010 a ‡ Ն Nephrology Division, cohort of 1248 patients with CKD stages 3 to 5 and previous nephrology care 1 year in 25 Italian outpa- Center of National tient nephrology clinics. Cumulative incidence of ESRD or death before ESRD were estimated using the Research-Institute of competing-risk approach. Biomedicine and Molecular Immunology Hospital, Reggio Results Estimated rates (per 100 patient-years) of ESRD and death 8.3 (95% confidence interval [CI], 7.4 to Calabria, Italy; 9.2) and 5.9 (95% CI 5.2 to 6.6), respectively. Risk of ESRD and death increased progressively from stages 3 §Nephrology Division, to 5. ESRD was more frequent than death in stage 4 and 5 CKD, whereas the opposite was true in stage 3 University Federico II, Naples, Italy; CKD. Younger age, lower body mass index, proteinuria, and high phosphate predicted ESRD, whereas ʈ Nephrology Division, older age, diabetes, previous cardiovascular disease, ESRD, proteinuria, high uric acid, and anemia pre- County Hospital, dicted death (P Ͻ 0.05 for all).
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