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COMMENT Supplementary information to: Find drugs that delay many diseases of old age List of co-signatories to a Comment published in Nature 554, 293–295 (2018) https://www.nature.com/articles/d41586-018-01668-0 Rafael DeCabo Senior investigator, Translational Gerontology Branch, National Institutes of Health, Baltimore, Maryland, USA. [email protected] Dan Ehninger Group Leader, German Centre for Neurodegenerative Disease, Bonn, Germany. [email protected] Adelaide Fernandes Assistant professor, Department of Biochemistry and Human Biology, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. [email protected] Susan E. Howlett Professor of Pharmacology and Medicine (Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada. [email protected] Ralph Müller Professor of Biomechanics, Institute for Biomechanics, ETH Zurich, Zurich, Switzerland. [email protected] Paul Potter Head of Disease Model Discovery, MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK. [email protected] Tamara Tchkonia Research Scientist, Assistant Professor, Robert and Arlene Kogod Center on Aging, Mayo Foundation for Medical Education and Research, Rochester, USA. [email protected] Anne-ulrike Trendelenburg Director of Muscle Programme, Novartis Institutes for Biomedical Research, Cambridge, USA. [email protected] Jose Luis Trejo Head of the Adult Neurogenesis Group, Department of Molecular, Cellular and Developmental Neuroscience, Cajal Institute — CSIC, Madrid, Spain. [email protected] Roosmarijn Vandenbroucke Group Leader, VIB UGENT Centre for Inflammation Research, University of Ghent, Belgium. [email protected] Ronald van Os Staff Advisor, Research and Development Facility, Central Animal Facility, European Research Institute for the Biology of Ageing (ERIBA), University Medical Centre Groningen, University of Groningen, the Netherlands. [email protected] Natal van Riel Professor of computational modelling, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven; and Academic Medical Centre, University of Amsterdam, the Netherlands. [email protected] SUPPLEMENTARY INFORMATION | NATURE | 1.

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University Medical Center of the University of Groningen Research Portfolio
University Medical Center of the University of Groningen Research portfolio Research Institutes and Research Programmes UMCG’s multidisciplinary Research Programmes are organised in five Research Institutes. Each Institute covers a specific part of the UMCG research area. By establishing numerous international research projects and strategic alliances over the past, research within the Institutes bridged national boundaries. Especially for the UMCG focus "Active and Healty Ageing" international collaboration is required and prepares the UMCG to contribute to this global challenge. For every UMCG Research Programme the relevance for Healthy Ageing is defined. Regarding the training and education of future scientists (MSc and PhD) the five Research Institutes collaborate in the Graduate School of Medical Sciences assuring the incorporation of state of the art scientific know-how. 1. GUIDE Institute: Chronic Diseases and Drug Exploration 2. BCN-BRAIN Institute: Behavioural and Cognitive Neurosciences 3. SHARE Institute: Health Research and Epidemiology 4. W.J.Kolff Institute: Biomaterials 5. CRCG Institute: Fundamental, Clinical and Translational Cancer Research Some of the Research Programmes are Platform Programmes, embedded in and supporting all five Research Institutes. Contents: Research programmes GUIDE 02-26 Research programmes BCN-BRAIN 27-35 Research programmes SHARE 36-46 Research programmes CRCG 47-55 Research programmes W.J. Kolff 56-65 Platform programme Center Medical Imaging 66-68 1 RESEARCH INSTITUTE GUIDE: Chronic Diseases and Drug Exploration 1. Biopharmaceuticals, Discovery, Design and Delivery (GUIDE-BDDD) Programme leaders: prof. dr. H.W. Frijlink, prof. dr. K. Poelstra Mission The BDDD Division explores innovative approaches oriented towards the early phase of drug development up to the use of these approaches in practice.
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Matchmaking event University of Groningen/UMCG and University of Chile 24-25 September, 2019 Time slot Tuesday 24th Location 09:00-10:30 Health Kick-off ERIBA Seminar Room 10:30-11:00 Break ERIBA Pantry 11:00-13:00 Parallel session Time Neuroscience & Biology of ageing (ERIBA seminar room) Time Oncology & Drug Delivery (Room 16) 11:00-11:25 Felipe Court: 11:00-11:20 Andrew Quest: Necroaxoptosis: a novel axonal degenerative mechanism involved in pathologies of the ageing nervous system From tumor suppressor to metastasis promoter – Caveolin-1, a Jack-of-all trades in cancer 11:25-11:40 Marco Demaria: 11:20-11:40 Frank Kruyt: Role of cellular senescence in health and disease Brain tumors: glioblastoma stem cell models and identification of new therapeutic targets 11:40-12:02 Miguel Concha: 11:40-12:00 Marcelo Kogan: Nothobranchious furzeru as a model of aging and neurodegeneration Nanoplatforms for drug delivery, theraphy and diagnostic of chronic diseases 12:05-12:20 Harrie Kampinga: 12:00-12:20 Paul de Vos: Protein homeostasis and age-related protein aggregation diseases Carbohydrates and microbiota in health 12:20-12:45 Christian González-Billault: 12:20-12:40 Inge Zuhorn: Understanding neuronal aging using cell culture models Drug Delivery across the Blood-Brain Barrier 12:45-13:00 Amalia Dolga: 12:40-13:00 Wijnand Helfrich: Targeting mitochondria in human neurodegenerative disease model systems Novel Targeted approaches in Cancer Immunotherapy 13-14:30 Lunch ERIBA Pantry 15:00-17:30 Parallel session Time Neuroscience & Biology of ageing
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Annual Report V2.Indd 1 16-07-2020 20:59 Welcome to Our Annual Report 2019
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Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Graphical abstract Authors Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, ..., Marco Demaria, Arvind Ramanathan, Judith Campisi Correspondence [email protected] (C.D.W.), [email protected] (A.R.), [email protected] (J.C.) In brief Senolytics, transgenic, and pharmacological interventions that selectively kill senescent cells are currently in clinical trials aiming to treat age-related degenerative pathologies. Here, Wiley et al. discover that senescent cells produce multiple signaling lipids known as oxylipins. One oxylipin, dihomo-15d-PGJ2, promotes features of senescence by activating RAS and is released from cells during senolysis, serving as the ﬁrst biomarker of the Highlights process in culture and in vivo. d Senescent cells make several oxylipins, dihomo- prostaglandins, and leukotrienes d Dihomo-15d-PGJ2 is intracellular during senescence and released during senolysis d Dihomo-15d-PGJ2 activates RAS, promoting senescence and the SASP d Positive feedback between prostaglandins, RAS, and p53 maintains senescence Wiley et al., 2021, Cell Metabolism 33, 1–13 June 1, 2021 ª 2021 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2021.03.008 ll Please cite this article in press as: Wiley et al., Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis, Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.03.008 ll Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Christopher D. Wiley,1,2,* Rishi Sharma,1 Sonnet S. Davis,1 Jose Alberto Lopez-Dominguez,1 Kylie P. Mitchell,1 Samantha Wiley,1 Fatouma Alimirah,1 Dong Eun Kim,1 Therese Payne,1 Andrew Rosko,1 Eliezer Aimontche,1 Sharvari M.
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European Research Institute for the Biology of Ageing
European Research Institute for the Biology of Ageing To better understand what causes ageing Foreword A better understanding of the cellular processes that cause ageing is important from a scientific as well as a “healthy ageing” perspective. This is the research area of the European Research Institute for the Biology of Ageing (ERIBA). This brochure explains why such research is important and what it is that we do. Research on the biology of ageing has been carried out for decades by numerous scientists all over the world. Yet our knowledge of the cellular processes that have been implicated is still far from complete. Fragmentation and compartmentalisation of the very wide research area is partly to blame. However, the insights that do exist also need to be better integrated. As a new institute, ERIBA aims to play a major role in the acquisition of new knowledge as well as in the integration of existing knowledge in all areas related to the biology of ageing. In 2007 the first plans were made at the University Medical Centre in Groningen (UMCG) for a new research Institute that could support, via fundamental research, the strategic choice for ‘Healthy Ageing’. Collaboration was sought betterTo understand what causes ageing. with the University of Groningen and other local, national and European ||| 3 partners. In 2009 this resulted in a concrete business plan. In 2010 the construction plans were drawn up and ERIBA was born in 2013. We started life in a modern building fully equipped to suit our vision that multidisciplinary work is a key ingredient to achieve breakthroughs in bio medical research.
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El Transhumanisme Sota La Lupa Francesc Torralba, Coordinador Conferències Curs 2017-2018
El Transhumanisme sota la lupa Francesc Torralba, coordinador Conferències curs 2017-2018 T E H E M O C R L U B O F BARCELONA Francesc Torralba Roselló és filòsof i teòleg. Neix a Barcelona el 15 de maig de 1967. Casat i pare de 5 fills. Doctor en Filosofia per la Universitat de Barcelona (1992). Doctor en Teologia per la Facultat de Teologia de Catalunya (1997). Doctor en Pedagogia per la Universitat Ramon Llull (2018). Amplia estudis a les Universitats de Copenhaguen i Berlín. En l’actualitat és catedràtic acreditat a la Universitat Ramon Llull, i imparteix cursos i seminaris en altres universitats d’Espanya i d’Amèrica. Alterna la seva activitat docent amb l’ofici d’escriure, i divulgar el seu pensament. Francesc Torralba és un autor prolífic, amb més de 1.500 articles i 100 llibres publicats dels quals destaquem: "El sentit de la vida" (2008), Biblioteca Francesc Torralba dedicada a valors amb títols com "La Tendresa", "La Paciència" o "L'Amistat", (2008), "Inteligencia Espiritual" (2010), "Jesucrist 2.0" (2011), "El valor de tenir valors" (2012), "Un mar d'e- mocions" (2013), "Córrer per pensar i sentir" (2015), "Saber dir no" (2016) i "La vida secreta de la pregària" (2017). Part de la seva obra ha estat traduïda al castellà, l'a- lemany, el francès, l'italià, el portuguès, el romanès i l'anglès. ament. EL TRANSHUMANISME SOTA LA LUPA Conferències curs 2017-2018 Amb la col.laboració de: Disseny i impressió: Vanguard Gràfic, SA ÍNDEX Introducción, de Jaime Lanaspa . 5 ¿De què parlem quan parlem de transhumanisme?, de Francesc Torralba .
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Scientific Programme Monday, 09 September 2019 09:00
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BGI Founder and President Visits EMBO the Stars of Biomedicine The
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Therapeutic Interventions for Aging: the Case of Cellular Senescence, Drug Discov Today (2017), J.Drudis.2017.01.004
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