NEWSLETTER PP 100000910 ISSN 1442-8725 December 2014

Clinical and Translational Immunology: A new platform to publish your research

Gabrielle Belz* and Rajiv Khanna¶ *Editor-in-Chief, Clinical & Translational Immunology, Walter and Eliza Hall Institute, Melbourne, Vic. ¶Deputy Editor, Clinical & Translational Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Qld.

Clinical & Translational Immunology diseases. We have also published solicited effi cacy in the treatment of malignant is a joint initiative of The Australasian reviews on timely topics in basic/clinical melanoma. However, IL-21 therapy can Society for Immunology (ASI) and Nature immunology. In addition, we also publish rapidly and potently induce natural killer Publishing Group (NPG). This journal is an ground-breaking case reports and letters to and cytotoxic T cell activation in patients, open access journal and is a companion title the editor. implying that this cytokine may yet be to Immunology & Cell Biology (published useful in stimulating the immune response by NPG in partnership with the ASI). The All content published in Clinical & to cancers. Dale Godfrey and Jonathan changing landscape of the immunology Translational Immunology is open access Coquet, now at the Flemish Institute of fi eld has resulted in an increasing focus and is freely available to researchers Biotechnology in Ghent, Belgium, and his on excellent clinical immunology and worldwide through the nature.com platform. colleagues now report that IL-21 therapy translational research, with a corresponding We are delighted to announce Clinical & in patients with malignant melanoma increase in submissions on these topics. Translational Immunology was recently modulates the function of NKT cells, a The pioneering work undertaken by many accepted in to PubMed Central. We expect Australian Immunologists highlights the all ASI members to support this exciting cont.p4 translation of critical basic research to the initiative and submit their research to clinic. Owing to the emergence of new Clinical & Translational Immunology. robust approaches to investigating clinical We also welcome any proposal to write disease, the development of new disease comprehensive reviews or special features Contents models that much more closely mimic the focusing specifi c topics/diseases/clinical human setting (e.g. humanized mice) and settings. If you are interested in submitting Clinical & Translational Immunology 1 translation of fi ndings back into the clinic, any proposal please contact our editorial Editorial 3 ASI decided that a new journal is merited offi ce: cti.offi ce@wehi.edu.au 2014 Eureka Prize 3 to host a venue for these studies. Clinical Upcoming Conferences 7 & Translational Immunology is aiming to Please visit our website for more details: publish the latest advances in biomedical http://www.nature.com/cti/index.html President’s Column 8 research for scientists and physicians. The Honorary Secretary’s News 10 journal focuses on fi elds such as cancer Since launching in late 2012, the journal has Visiting Speaker Program 11 biology, cardiovascular research, gene published a number of outstanding articles by therapy, immunology, vaccine development world-renowned experts. A brief summary of ICB Publication of the Year Awards 15 and disease pathogenesis and therapy at the these contributions is provided below. Councillors’ News 17 earliest phases of investigation. Clinical & Travel Award Conference Reports 20 Translational Immunology publishes articles Cancer: Late-stage melanoma patients on basic, translational, and clinical studies in respond to immunotherapy Publications List 24 all aspects of human immunology, including Immunotherapy with a cytokine called experimental models specifi c to human interleukin-21 (IL-21) has shown modest ASI Inc. Newsletter December 2014

ASI Inc. COUNCIL Non-Voting Councillors: Newsletter Editor President Vice President Dr Simon Apte Professor Dale Godfrey Professor Christopher Goodnow Ph: 61 7 3362 0380 Dept Microbiology & Immunology Department of Immunology Email: [email protected] Peter Doherty Institute JCSMR, ANU University of Melbourne Parkville Vic 3010 PO Box 334, Canberra ACT 2601 Journal Editor Ph: 61 3 8344 6831 Ph: 61 2 6125 2394 Dr Gabrielle Belz Email: [email protected] Email: [email protected] Ph: 61 3 9345 2544 Fax: 61 3 9347 0852 Email: [email protected] Honorary Secretary Honorary Treasurer A/Prof. Stuart Berzins Dr John Stambas Visiting Speakers Co-ordinator CRN Section, School of Health Sciences AAHL, CSIRO Deakin Collaborative Lab. A/Prof. J. Alejandro Lopez Federation University Australia Private Bag 24 Ph: 61 7 3845 3794 Fax: 61 7 3845 3510 Mt Helen Vic 3352 East Geelong Vic 3220 Email: a.lopez@griffi th.edu.au Ph: 61 3 5320 2039 Ph: 61 3 5227 5740 Email: [email protected] Email: [email protected] Day of Immunology Co-ordinator Dr Claerwen Jones Branch Councillors Ph: 61 3 8344 9595 Fax: 61 3 9347 1540 New South Wales Victoria & Tasmania Email: [email protected] Dr Marcel Batten Dr Daniel Gray Ph: 61 2 9295 8412 Ph: 61 3 9345 2497 Meeting Co-ordinator Email: [email protected] Email: [email protected] Dr Susanne Heinzel Ph: 61 3 9345 2609 Fax: 61 3 9347 0852 Queensland South Australia & Northern Territory Email: [email protected] Dr Kristen Radford Dr Cara Fraser Ph: 61 7 3443 7638 Ph: 0422 903 093 Council Member of IUIS Email: [email protected] Email: [email protected] Professor Alan Baxter Ph: 61 7 4781 6265 Western Australia Australian Capital Territory Email: [email protected] Dr Andrew Currie Dr Anselm Enders Ph: 61 8 9360 7426 Ph: 61 2 6125 7605 FIMSA Councillor Email: [email protected] Email: [email protected] Professor Alan Baxter Ph: 61 7 4781 6265 New Zealand Email: [email protected] Dr Roslyn Kemp Ph: 64 3 479 7708 Honorary Archivist: Email: [email protected] Dr Judith Greer Project Manager Ph: 61 7 3346 6018 Miss Sarah Fardy Email: [email protected] Ph: 61 3 5227 5794 / 0413 917 990 ICI2016 Councillor Email: [email protected] Professor Jose Villadangos Administrative Correspondence Ph: 61 3 9035 7684 Ms Judi Anderson Email: [email protected] ASI Inc. Secretariat PO Box 7108 Upper Ferntree Gully Vic 3156 Ph: 61 3 9756 0128 Fax: 61 3 9753 6372 Email: [email protected]

The New ASI Website The ASI web site (www.immunology.org.au) has been fully remodelled and updated. New services include: Links providing members with free access to Immunology & Cell Biology, Nature Immunology, Nature Reviews Immunology Special offers for ASI members Download and upload forms for ASI awards Positions vacant page Online membership renewal Upcoming conference listings Women's initiative Twitter feed as well as many links to sites of immunological interest at home and abroad. If you would like to advertise a job or conference, or if you have an immunology news story, or a favourite immunology-related site that you would like to see linked to the ASI website, please email Sarah Fardy at [email protected]

2 ASI Inc. Newsletter December 2014

EDITORIAL 2014 EUREKA PRIZE This edition we showcase interesting B-CELL MYSTERY BUSTED AT LAST articles from our newer journal – Clinical and Translational Immunology. I hope you have time to look at the articles –I was particularly fascinated by the approach taken by Tuckweng Kok and colleagues to produce designer HIV antigens. It’s great to see ASI’s journals getting so much traction and congratulations to the Editorial teams of both ICB and CTI for guiding these journals so well. It is timely to review our publication statistics for the last year. I have been compiling the publication list for four years now and the pattern of publication has remained fairly similar, with the top ten journals accounting for about 30% of our publications. It’s great to see ICB in third place, but given that its impact factor is now so much better than PLOS One, I’d expect to see it in second place by the end of the New Year.

2014 Eureka Prize winning team. LtoR: Steven Nutt, Lynn Corcoran, Phil Hodgkin, David Tarlinton (Photo courtesy Australian Museum)

A team of Melbourne researchers has of immune cells along the way. Until now the fi nally unravelled the workings of the rare, lack of understanding of this process—how specialised cells in our blood that generate the resulting ASCs ‘choose’ which antibody antibodies to fi ght infection and disease. to make, and how they survive for long periods—has been a barrier holding back Known as antibody secreting cells (ASCs), the design of effi cient vaccines and immune This is my last Edition as Newsletter Editor. they start life as B-cells in the bone marrow. defi ciency treatments. I’d like to give special thanks to Judi Our immune system carefully manages Anderson (at the ASI Secretariat) who always them every step of the way to protect “Philip Hodgkin’s team took a unique does a sterling job putting the Newsletter against immune defi ciency and ensure that approach to solve this problem, and have together; and thanks to all the ASI members appropriate levels of the right antibodies are fi nally revealed how the different immune who contributed or assisted in different ways maintained. cells are made,” Australian Museum Director over the last four years. A big welcome to the and CEO Kim McKay said. “This is a step- incoming Newsletter Editor, Joanna Roberts, For their elegant theory explaining how increase in our understanding that will aid the thanks for coming on board! ASC cells are produced, Professor Philip global effort to develop immune defi ciency Hodgkin’s team at the Walter and Eliza Hall treatments and vaccines.” One thing you become aware of if you become Institute of Medical Research has won the involved with the organizational side of ASI University of New South Wales Eureka Prize The Australian Museum Eureka Prizes are is the huge amount of work the Council does for Scientifi c Research. the country’s most comprehensive national behind the scenes. The Executive members, science awards. The Eureka Prizes have been in particular, devote a lot of their own time To produce the antibodies essential for long- rewarding science since 1990—celebrating and effort and they really deserve credit and term protection against infection, B-cells 25 years in 2014. thanks – well done! develop into ASCs, budding off other types Finally, a safe and happy holiday season to you all, I hope you come back refreshed and ready to write brilliant grant applications! Simon Apte 3 ASI Inc. Newsletter December 2014

Clinical & Translational Immunology (cont) synovial dendritic cells but not by cultured dendritic cells from blood, unless treated with vitamin D. The cells also differed in other responses to vitamin D and the biological factor lipopolysaccharide. The common practice of using cultured cells from blood to study the dendritic cells that accumulate in arthritic joints warrants further investigation. See more details on this article at http:// www.nature.com/cti/journal/v3/n8/abs/ cti201419a.html

Infl uenza: Learning how viruses fi nd a welcoming host Researchers in India have explored how Tuckweng Kok viral variation and host genetics combine to determine susceptibility to infl uenza Dale Godfrey have failed. The new approach could help infection. Mutations in the infl uenza genome to produce broadly neutralizing antibodies can render the virus more or less virulent population with the potential to mediate or antiviral agents that reduce the risk of but an individual’s ability to generate an the rejection of cancers. IL-21 enhanced HIV transmission. effective immune response against a given NKT cell granularity, and modulated the strain is also critical. Sumanta Mukherjee expression of cell surface receptors and See more details on this article at http:// and Nagasuma Chandra of the Indian cytokines produced by NKT cells. In www.nature.com/cti/journal/v3/n9/abs/ Institute of Science in Bangalore used a particular, IL-21 shifted the balance of Th1/ cti201422a.html computational approach to examine human Th2 cytokines produced by NKT cells. In leukocyte antigen (HLA) genesin different addition, the authors note that a population Rheumatology: Cellular models of populations. These highly variable genes of ‘NKT-like’ cells is expanded by IL-21 arthritis affect how viral antigens are presented therapy and single out this population for Australian researchers have examined the to the immune system. Comparing these further studies. These results demonstrate validity of using cultured cells from blood data against genome and protein data from that IL-21 therapy is a potent modulator to model cells in joints with rheumatoid different viral strains revealed that immune of the function of immune cells including, arthritis. Rheumatoid arthritis is an auto- ‘response types’ correlated with the NKT cells. immune disease in which the immune system likelihood of an infection or outbreak. In attacks the synovium, a thin membrane that addition to predicting susceptibility, these See more details on this article at http:// lines joints. A team led by Leslie Cleland data could also inform the design of more www.nature.com/cti/journal/v2/n10/abs/ of the Royal Adelaide Hospital compared effective vaccines. cti20137a.html dendritic immune cells from the synovial fl uid of infl amed joints with monocyte See more details on this article at http:// HIV: Designer antigens for elicitation of derived dendritic cells cultured from the www.nature.com/cti/journal/v3/n8/abs/ broadly neutralizing antibodies patients’ blood. Prostaglandin D-synthase, cti201417a.html Researchers have produced designer an enzyme which acts in the resolution antigens that can elicit novel HIV of infl ammation, was expressed the antibodies which may have the potential to effectively prevent infection. The work, led by Tuckweng Kok and Peng Li at the University of Adelaide, Australia, exploited the fact that in rare cases HIV patients can produce neutralizing antibodies that bind to sites which exist only transiently as the virus fuses with cells. They created long- lasting versions of these sites in a cellular model by lowering the temperature to arrest fusion midway through. This allowed time to produce antibodies that selectively bound to cells that were in the process of being infected, and potentially reduce the ability of HIV to infect cells. Previous attempts to make vaccines that produce Nagasuma Chandra broadly neutralizing antibodies in patients Leslie Cleland

4 ASI Inc. Newsletter December 2014

Eric Gowans Kenneth Smith Bitao Liang

Immunization: Enhancing the immune can modify infl ammatory responses, affect See more details on this article at http:// response to DNA vaccines the clinical outcome of several different www.nature.com/cti/journal/v3/n5/abs/ Researchers are exploring strategies for diseases, including rheumatoid arthritis, cti20145a.html improving immune responses to DNA malaria and Crohn’s disease, a disabling vaccines. Eric Gowans at The University form of infl ammatory bowel disease. The Allergy: Fighting food-fuelled of Adelaide, Australia, and colleagues authors argue that a better understanding infl ammation inserted DNA encoding a model antigen of the role of genetics in determining the Immune cells belonging to the subset into a virus-like membrane. Mice that prognosis of autoimmune and infectious responsible for food allergy-associated inhaled this vaccine and then had it injected diseases could shed new light on disease infl ammation offers promising targets for into their skin showed a robust immune biology, reveal new therapeutic targets and potential therapeutics. Patients suffering response in mucosal surfaces including the lead to personalized treatments for these from the painful symptoms of eosinophilic vagina. These mucosal responses are key conditions. esophagitis (EoE) have few options except determinants of a vaccine’s effi cacy against for dietary modifi cation. Researchers led sexually transmitted diseases. A second See more details on this article at http:// by Anil Mishra at Tulane University, USA, approach examined the effect of encoding www.nature.com/cti/journal/v3/n5/abs/ have identifi ed a prominent role for innate a cytolytic protein in the DNA vaccine. cti20148a.html natural killer T (iNKT) cells in EoE, thereby This showed that an optimum balance uncovering signaling pathways that might between expression of the immunogen and Immunity: Seeking out secrets of placental be blocked to halt this condition. The team the cytolytic protein increased immune protection observed greatly increased recruitment of responses, resulting from cross presentation The same mechanisms that protect iNKT cells in esophageal biopsies from of the immunogen. DNA vaccines are the fetus from the mother’s immune EoE patients, and showed that EoE-like cheap to make and easy to store, making system could help keep autoimmune and symptoms can no longer be induced in them ideal for use in developing countries, infl ammatory diseases at bay. A growing mice that lack these cells specifi cally. but it is currently diffi cult to get them to body of evidence suggests that placental generate a suffi cient immune response. cells promote maternal tolerance for fetal tissues that might otherwise be perceived See more details on this article at http:// as ‘foreign’. Bitao Liang and colleagues at www.nature.com/cti/journal/v3/n6/abs/ Celgene Cellular Therapeutics in Warren, cti201413a.html New Jersey, USA, examined the role of cultured human ‘placenta-derived adherent Immunity: Genetics underlies disease cells’ (PDAC® cells), with a view toward prognosis developing these cells as therapeutic tools. How a person responds to autoimmune Cell culture and animal model experiments and infectious diseases depends to a large both demonstrated that PDAC® cells can extent on his or her unique genetic profi le. help restrict proliferation and activation In a review article, James Lee and Kenneth of T-cell subsets associated with certain Smith from the Cambridge Institute for immune disorders. The authors found Medical Research in the UK highlight the that this occurs through direct effects on previously unappreciated role that genetics T cells and also through factors secreted plays in affecting disease outcome, in by PDAC® cells. These factors promote addition to its known effects on disease development of particular immune cells that susceptibility. The authors focus on their help limit the overall immune response. recently published work, which showed that genetic variants in FOXO3, a gene that Anil Mishra

5 ASI Inc. Newsletter December 2014

Importantly, iNKT function depends on certain cell-surface proteins that can be effectively blocked by existing antibodies. Mishra and colleagues demonstrated that these antibodies prevent allergen-induced EoE in mice, and might therefore confer similar protection in humans.

See more details on this article at http:// www.nature.com/cti/journal/v3/n1/abs/ Charlotte Ariyan cti201313a.html molecules that normally inhibit anti-cancer Multiple sclerosis: Seeking an early T cell responses. In clinical trials, these warning of autoimmunity antibody drugs have dramatically improved A molecule secreted by gut microbes may survival rates in people with advanced improve the diagnosis of multiple sclerosis melanoma. But the drugs also come with a (MS) and offer a window into the roots of Pranela Rameshwar host of immune-related side effects, such as this autoimmune disorder. Although broadly tissue-specifi c infl ammation, highlighting understood as a disease in which genes and Allergic diseases: Same cell therapy, the delicate balance of maintaining a healthy environment interact resulting in the body opposite responses immune system. Intriguingly, melanoma attacking its own nervous system, scientists Individuals with allergic infl ammation of patients who experience side effects are know little about the causes of MS or the the nasal airways may respond differently more likely to respond to immunotherapy, environmental factors involved in its onset. to stem cell therapy than individuals with suggesting that physicians can use adverse However, a team led by Robert Clark at the allergic asthma, a cell-based study shows. event profi les to predict who will respond University of Connecticut Health Center has Pranela Rameshwar and her colleagues and to guide therapy accordingly. discovered a molecule produced by human at the Rutgers University–New Jersey commensal bacteria that may offer both a Medical School, USA, tested the effects See more details on this article at clue to relevant environmental factors and of adding mesenchymal stem cells (MSCs) a useful diagnostic tool. The researchers to blood samples from subjects with either Immunology: Tracking health through determined that the molecule, termed ’lipid allergic rhinitis, commonly known as hay mother’s milk 654‘, was consistently found at greatly fever, or allergic asthma. The researchers By quantifying immune cell levels in reduced levels in the blood of MS patients fi rst extracted a subset of blood cells breastmilk, researchers in Australia relative to healthy individuals or patients containing many important components of have found an indicator of the health of with an unrelated neurological disorder. the immune system, including peripheral mothers and their babies. Breastfeeding Furthermore, as lipid 654 specifi cally binds blood mononuclear cells (PBMCs). They babies receive numerous health benefi ts to an important human immune signaling then challenged the PBMCs to immune- from their mothers, including factors protein, it could play a role in regulating triggering antigens such as ragweed, before that help them fi ght bacteria and viruses. the autoimmune response. introducing MSCs. The stem cells had a Since the quantity of white blood cells suppressive effect on the immune system found in breastmilk might offer a window See more details on this article at http:// in samples from asthma sufferers, but an onto infant and maternal health, Foteini www.nature.com/cti/journal/v2/n11/abs/ immune-enhancing effect on samples from Hassiotou and her colleagues at the cti201311a.html people with allergic rhinitis — despite the University of Western Australia measured typical infl ammatory response being similar how these levels shift in healthy or infected in both rhinitis and asthma sufferers.

See more details on this article at http:// www.nature.com/cti/journal/v2/n10/abs/ cti20139a.html

Cancer therapy: Drugs rouse immune system against skin cancer Immune-modulating therapies that stimulate a person’s immune system to recognize and destroy tumor cells are showing great promise in fi ghting advanced melanoma skin cancer. Charlotte Ariyan and her colleagues at the Memorial Sloan- Kettering Cancer Center in New York City, USA, have reviewed the melanoma drugs Robert Clark that work by blocking critical checkpoint Foteini Hassiotou

6 ASI Inc. Newsletter December 2014 nursing mothers and their babies. They See more details on this article at http:// found that white blood cell levels in milk www.nature.com/cti/journal/v2/n4/abs/ An invitation and a request reached a low baseline shortly after birth, cti20132a.html but increased dramatically in response to to all ASI members infection in either infant or mother. After We hope you will consider submitting your to contribute copy that they think might be interesting, useful, historical, an infection cleared, milk immune cell next manuscript to Clinical & Translational humorous or thought provoking. levels returned to baseline, indicating that Immunology to showcase your next piece such measurements might offer a valuable of research, and benefi t from: We invite our student membership diagnostic tool to assess health. to voice their views on issues • High visibility for your research: a that interest or directly concern See more details on this article at http:// recent study indicates that open access them. www.nature.com/cti/journal/v2/n4/abs/ articles are viewed 3 times more cti20131a.html often than articles only available to It’s our newsletter, so let’s subscribers* support it and strive to make it even better. Immunology: Existing drugs may treat • Over 4,000 table of contents registrants systemic sclerosis and 7,000 page views every month An exploration of a signaling protein’s The ASI newsletter comes out role in an untreatable infl ammatory disease • Easy and quick online submission 4 times a year and we welcome offers hope that available therapeutics may system your contributions. provide relief. Systemic sclerosis (SSc) • Rapid and rigorous peer review AND YOU COULD WIN manifests differently in individual patients, • Average time to fi rst decision is 21 $200 FOR THE BEST but is generally associated with both days ARTICLE PUBLISHED IN infl ammation and accumulation of fi brous • Wide dissemination: articles are THE NEWSLETTER! tissue. Both processes are potentially published under a Creative Commons modulated by signaling factor interleukin- License and are permanently and 6 (IL-6). Steven O’Reilly and colleagues freely available for all to read, use and from the Institute of Cellular Medicine in cite Newcastle-upon-Tyne, UK, have reviewed • Free manuscript deposit service to Pub the evidence linking excessive IL-6 Med Central activity to SSc. For example, SSc patients commonly exhibit elevated IL-6 levels in Find out more: www.nature.com/cti the blood and increased signaling activity at the skin, where fi brosis typically occurs. *Research Information Network (RIN), Experiments in a mouse model of SSC 2014 also indicate that reducing IL-6 signaling activity can mitigate symptoms. Several drug candidates for rheumatoid arthritis UPCOMING CONFERENCES target this signaling pathway, and ongoing clinical trials should reveal whether SSc 1st International Convention Immunophar- 8th Frontiers in Immunology Research patients stand to benefi t. macology-Vaccipharma 2015 2015 International Conference 14–19 June 2015 1–4 July 2015 Cuba Albufeira, Algarve, Portugal http://www.immunovaccipharmacuba.com hkan@fi rnweb.com http://www.fi rnweb.com FIMSA2015 http://twitter.com/Immunology_Conf 30 June–3 July 2015 Abstract submission deadline: 30 March Singapore 2015 [email protected] www.sgsi.org.sg 4th European Congress of Immunology 6–9 September 2015 Vienna, Austria www.eci-vienna2015.org

The Walter and Eliza Hall Institute of Medical Research Steven O’Reilly WEHI Seminars on the Web: www.wehi.edu/seminars/

7 ASI Inc. Newsletter December 2014

PRESIDENT’S COLUMN

It is diffi cult for me to believe that here I am, already writing my fi nal President’s column, when it feels like only a few weeks have passed since I fi rst stepped into this position. But by the time you are reading this, ASI will have a new ‘El Presidente’, Chris Goodnow, and I will be lying on a beach somewhere, refl ecting on all the things ASI Council has achieved under my presidency and wondering what to do with all my spare time. It has been a challenge at times to manage the role of ASI President simultaneously with all the other demands of medical research. But that said, I am very glad to have had this opportunity to take the reins of ASI for the last two years and I hope that some of the things that have been introduced have improved the member benefi ts and the running of the Society. I also encourage anyone who is interested in playing a more direct role in our Society to membership. I am pleased to say that be taking on additional initiatives that we talk to me about it. It can be a very rewarding this has been quite successful as ASI hope will further enrich the membership thing to do. currently has seven sustaining members: experience. Many thanks to the two Sarahs Jomar Bioscience/E-bioscience; Miltenyi for their efforts over the past 1½ years, for In my fi rst newsletter I talked about how Biotec; Becton Dickinson; Elisakit.com; actually ensuring that these new initiatives the things that are achieved under any Stem Cell Technologies; the ARC Centre happen, and for making the life of ASI Exec given presidency are typically part of a of Excellence for Advanced Molecular and Council a lot easier. continuum, building on the seeds planted Imaging; Abcam Australia Pty Ltd, with by previous presidents and councils and promises of new sustaining members for Another signifi cant change that has been carried through by subsequent president/ next year. In these fi nancially challenging introduced recently is the creation of a new councils. My own experience over the past times, it is increasingly diffi cult to attract Council position, the Deputy Treasurer. two years refl ects this. I am pleased to say sponsorship and support from companies This was created to solve the challenging that one of the key achievements has been to who have to be careful how they distribute problem that ASI Treasurers are thrown complete the ASI website upgrade, initiated their limited funds, yet our Society depends in the deep end at the beginning of their by previous president David Tarlinton. on this support. So a request to all members tenure and it takes a considerable amount This is now having a major impact on how – please be sure to visit these companies via of time to get to know how to manage the we communicate with the membership. our website and if you are talking to any of fi nances of such a big and active Society. Associated with this website, we have: their representatives at conferences, let them Our solution was to introduce the position much greater involvement with social media know that members of our Society notice and of Deputy Treasurer, providing a year of including Twitter and Facebook; the ASI appreciate their support. training alongside the existing Treasurer to women’s initiative and its various features ensure a smooth transition at the end of the to help the many female members of our The development and management of three-year Treasurer term. Assuming that Society; regular Immunology-related news initiatives such as the new website has this new position will have been approved stories; job opportunities and conference been largely facilitated by the ASI Project at the AGM this year, I am very pleased to promotions; and the excitement of an Offi cer(s) (previously Sarah Jones, now Sarah welcome ASI’s fi rst Deputy Treasurer, Kim occasional competition. ASI membership Fardy). This position also grew out of David Jacobson. After a year as Deputy Treasurer, renewal, travel award applications and the Tarlinton’s presidency and was approved at Kim will take over from current Treasurer, ability to manage payments for various the 2012 Annual General Meeting. Sarah John Stambas, immediately after the annual ASI-related activities such as branch-based Jones took on this role early in 2013, and general meeting at the end of 2015. meetings can all be conducted online as a she was instrumental in getting the website result of this new website. up and running. Sarah resigned from this While on the subject of new Council position to focus on her research career early appointments, I am also very pleased One of the things we envisioned with in 2014 and Sarah Fardy took over and has to welcome Mainthan Palendira as ASI this website would be the opportunity to continued to enhance and develop the website NSW Councillor, Joanna Roberts as ASI increase our sustaining member program, over the past 10 months. With the website Newsletter Editor and Joanna Kirman as raising more money for the Society and now running smoothly, Sarah, who is most ASI Visiting Speaker Co-ordinator. This is giving sponsors greater exposure to the enthusiastic and never short of an idea, will also an opportunity to offer my thanks, on 8 ASI Inc. Newsletter December 2014 behalf of ASI Council and membership, for the scientists from each country to interact. cite appropriate papers from them, etc. All the great service to our Society provided There will also be travel opportunities for ASI these things help boost these journals and by the outgoing Councillors including: members to attend the meeting in Germany this helps boost our Society. NSW Councillor Marcel Batten; Newsletter the following year. If this is successful, I Editor, Simon Apte; and Visiting Speaker envision that similar joint meetings between Obviously I will remain heavily involved Co-ordinator, Alejandro Lopez. It is a big ASI and other Immunology societies could with ASI over the year ahead as an executive deal to give so much of your time to helping become a regular event on the ASI calendar. I member (Past President), but the next run this Society, so give these people a pat hope that this is one of those things that will President’s column will come from Chris. on the back when next you see them. be part of the continuum – driven forward by I look forward to working with Chris Chris Goodnow and his successors. and helping him bring his own style and I am very enthusiastic about a new venture vision to ASI, in conjunction with the other for our Society (driven by Sammy Bedoui, One other thing worth mentioning, that Executive team members: John Stambas Anselm Enders, Su Heinzel and myself) I can’t take too much credit for but will (Treasurer), Stuart Berzins (Secretary), involving two reciprocal meetings with the pretend was all my doing anyway … we Sarah Fardy (Project Manager), Judi German Society for Immunology (Deutsche have seen the profi le of our two journals, Anderson (Secretariat), and the great team of Gesellschaft für Immunologie). The fi rst Immunology & Cell Biology, and Clinical councillors who have worked with me over meeting will dovetail with the ASI annual & Translational Immunology, growing very the past two years and undoubtedly will help scientifi c meeting in Canberra in 2015 and the nicely. ICB reached a new high this year Chris to keep our Society running. reciprocal meeting will be held in Germany with an impact factor of 4.205, and CTI is in 2016. The intention is that these meetings continuing to attract new articles and has So – thank you all – it has been a pleasure will provide new collaborative opportunities now been listed in PubMed Central, which and I am very grateful to the membership between the members of the two societies should further enhance its profi le. Many for giving me the chance to lead ASI over and I encourage members to register for thanks and congratulations to Gabrielle Belz, the last two years. the extra day of this meeting in Canberra Rajiv Khanna and the editorial team for their next year. We already have a great lineup of efforts in propelling these journals to new Dale Godfrey potential speakers from Germany who will heights. Again, I encourage all members ASI President 2013–2014 be attending and it promises to be a terrifi c to get behind these journals, submit your event, including some valuable social time for work there, make sure you read them and

9 ASI Inc. Newsletter December 2014

HONORARY SECRETARY’S NEWS

Results of Ballots for Vacant ASI Council Joanna Kirman has been elected as Co- These are highly competitive awards and Positions ordinator of the Visiting Speaker Program. the winners are to be congratulated for their Thanks to the members of ASI who nominated Joanna takes over from Alejandro Lopez, achievement. I should remind everyone to fi ll vacancies on ASI Council as Treasurer, who has run the VSP with aplomb for many that these awards are funded through your Newsletter Editor, Visiting Speaker Co- years and played a central role in developing membership fees so please sign up when the ordinator and NSW Branch Councillor. The the scheme into one of the most popular renewal information appears in your email results of the ballots were announced in programs run by ASI for its members. in the next few weeks. earlier correspondence, but I would like to formally congratulate and welcome the new Mainthan Palendira takes over from Marcel Website members of ASI Council, who will take up Batten as Branch Councillor for NSW. Marcel The ASI website (http://www.immunology. their positions on Wednesday 3rd December, had perhaps the busiest year of any ASI org.au/) goes from strength to strength under 2014 at the ASI AGM held during the Annual Councillor because she also served on the the stewardship of Sarah Fardy. It is now a Scientifi c Meeting in Wollongong. Organising Committee for this year’s Annual valuable resource for members, providing Scientifi c Meeting in Wollongong, while news and information about Immunology The new Deputy Treasurer is Kim Jacobson. maintaining a full time research career and and ASI-related activities, providing services Kim will spend 2015 learning the ropes from having a baby. A well earned break awaits such as payment facilities for conference and the current Treasurer, John Stambas, and will … until grant writing! event registration, and a submission area for serve as Treasurer from 2016-2018. applications. Please contact Sarah (fardy. ASI International Travel Awards [email protected]) if you have news, photos Joanna Roberts will take over as Newsletter Five awards of $3000 each have been and/or articles you would like to see posted Editor from Simon Apte. A huge thanks to awarded to ASI members for international on the website, including if you need help Simon for his excellent work over many travel to attend conferences and/or institutes. preparing this information. years. The winners of the postgraduate awards are Nicholas Gherardin, Emma Grant and Julia Stuart Berzins Marchingo. The winners of the postdoctoral awards are Alison Carey and Andreas Kupz.

AASISI iiss nownow onon FacebookFacebook andand TwitterTwitter For up-to-date information on all things ASI, including conferences, travel scholarships, prizes, visiting speakers and general immunology news.

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10 ASI Inc. Newsletter December 2014

THE ASI VISITING SPEAKER PROGRAM

It is with great pleasure that I type my 331: 44-49. last report for the ASI-VSP program. I Narni-Mancinelli E., Vivier E. NK genesis: a trick am very pleased that the program has of the TRAIL. Immunity, 2012, 36: 1-3. achieved suffi cient traction that we had Vivier E., Ugolini S., Blaise D., Chabannon C., Brossay L. Targeting Natural killer cells and three candidates willing to take the role natural killer T cells in cancer. Nature Reviews of coordinating this successful activity Immunol. 2012, 12: 239-252. of the society. I congratulate Jo Kirman Jaeger B.N., Vivier E. When Natural Killer cells (University of Otago, Dunedin, NZ) who has overcome their lack of education. J. Clin. Invest. been elected to continue the program from 2012, 122:3053. 2015 and I am certain she will re-invigorate Spits H., Artis D., Colonna M., Diefenbach A., and strengthen it to new heights. I wish Di Santo J.P., Eberl G., Koyasu S., Locksley to thank all the ASI members who have R.M. McKenzie A.N.J., Mebius R.E., Powrie enthusiastically supported this program in F., Vivier E. Innate Lymphoid Cells: a proposal for a uniform nomenclature. Nature Reviews the last 10 years as well as the various ASI Immunol. 2013. 13:145-149. Councils throughout this period for making Professor Eric Vivier Kerdiles Y., Ugolini S., Vivier E. T cell regulation the program successful. Very importantly, of Natural Killer cells. J. Exp. Med. 2013, 210: we are also indebted to Judi Anderson from d’Immunologie de Marseille-Luminy 1065-1068. the ASI Secretariat who, for so many years, since 2006. In 1993, after a post-doctoral Pradeu P., Jaeger S. Vivier E. The Speed of Change: has helped maintain the continuity of this fellowship at Harvard Medical School, Towards a Discontinuity Theory of Immunity. and many other activities of the ASI. he joined the CIML where he founded Nature Reviews Immunol. 2013, 13: 764-769. the Laboratory “Natural Killer Cells and Vivier E., Ugolini S., Nunès J.A. ADAPted cytokine secretion in Natural Killer cells. Nature We have secured a record number of visitors Innate Immunity” in 1996. This research Immunology, 2013, 14:1108-1110. for 2015 as you will see from the listing helped to elucidate the role of NK cells and Daëron M, Vivier E. Coincidence detection of below. We do encourage members to continue more broadly to decipher the molecular antibodies and interferon for sensing microbial to postulate their candidates for the program. mechanisms controlling their activation. context. Nature Immunology, 2014, 15: 316- At this point, visits are likely to take place 317. from 2016. Professor of Immunology at the Faculty Sun J.C., Ugolini S., Vivier E. Immunological of Medicine, Hospital practitioner at the Memory within the Innate Immune System. Planned visits for 2014 Timone Hospital and the Assistance- EMBO J., 2014; 33(12):1295-303. Professor Frederic Geissmann Publique Hospitals of Marseille, Eric Vivier Narni-Mancinelli N., Vivier E. Perforin, granulysin and granzymes: an anti-bacterial King’s College, London, UK opened the way for the development of tritherapy Prof. Geissmann will visit Melbourne, new therapeutic strategies against cancer provided by killer lymphocytes. Cell, Sydney and Canberra and infl ammatory diseases. He is one of the 2014;157(6):1251-2. This visit has been postponed for 2015 scientifi c founders of the biopharmaceutical Crouse J, Bedenikovic G, Wiesel M, Ibberson Hosted by Gabrielle Belz, WEHI company Innate Pharma, a pioneer of global M, Xenarios I, Von Laer D, Kalinke U, Vivier immunotherapy. E, Jonjic S, Oxenius A. Type I interferons Professor Peter Ghazal protect T cells against NK cell attack mediated Personal Chair of Molecular Genetics and Eric Vivier is a member of the Institut by the activating receptor NCR1. Immunity. Biomedicine Universitaire de France, member of the 2014;40(6):961-73. Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi University of Edinburgh, UK scientifi c committee of the LNCC (French PP, Jonjić S, Olive D, Dalod M, Vivier E, Nunès December 1-5, ASI conference National League against Cancer), scientifi c JA. Dok1 and Dok2 proteins regulate natural December 8/9, Melbourne, advisor for the Institute of Hematology- killer cell development and function. EMBO J. December 10/11, Perth Immunology-Pulmonology (INSERM) and 2014;33(17):1928-40. Hosted by Andrew Currie, Murdoch member of the expert committee for the Marçais A, Cherfi ls-Vicini J, Viant C, Degouve University, WA European Research Council (ERC) Starting S, Viel S, Fenis A, Rabilloud J, Mayol K, Grant. Professor Vivier will be spending Tavares A, Bienvenu J, Gangloff YG, Gilson E, 2015 six months Sabbatical period at the WEHI Vivier E, Walzer T. The metabolic checkpoint March and would visit various branches during kinase mTOR is essential for IL-15 signaling during the development and activation of NK Professor Eric Vivier this period. cells. Nat Immunol. 2014;15(8):749-57. Centre d’Immunologie de Marseille-Luminy, Viant C, Fenis A, Chicanne G, Payrastre B, France Selected publications in the last 4 years Ugolini S, Vivier E. SHP-1-mediated inhibitory Details of the visit to be announced Vivier E., Ugolini, S. Poster on NK cells: receptors signals promote responsiveness and anti-tumour Hosted by Gabrielle Belz, WEHI, Melbourne, and functions, Nature Reviews Immunology, functions of natural killer cells. Nat Commun. VIC 2010, 10: 12 2014;5:5108. Vivier E., Raulet D.H., Moretta A., Caligiuri Veterinarian and immunologist by training, M.A., Zitvogel L., Lanier L.L., Yokoyama W.M., Ugolini S. Innate or adaptive immunity? The Eric Vivier is Director of the Centre cont. next page example of Natural Killer cells. Science, 2011,

11 ASI Inc. Newsletter December 2014

Assistant Professor Alex Shalek transcriptional response strong enough to B.E., and Meissner, A., “Transcriptonal and MIT, Cambridge, USA show up at the population level. Epigenetic Dynamics during Specifi cation of Human Embryonic Stem Cells,” Cell, 153,1149, March 16. Auckland Much like the precociously- reacting bone- (2013). Suva, M. , Rheinbay, E., Gillespie, S.M., Patel, March 18. Wellington marrow- derived dendritic cells that they A.P., Chi, A.S., Riggi, N., Wakimoto, H., Rabkin, March 21. Melbourne have described as reacting to bacteria- S.D., Matuza, R.L., Rivera, M.N., Rossetti, N., March 25. Brisbane derived stimuli, Dr Shalek and colleagues Beik, S., Kasif, S., Wortman, I., Shalek, A.K., Hosted by Alexander Smith, Malaghan are the fl ag- bearers for these new single- Rozenblatt-Rosen, O., Regev, A., Louis, D.N., Institute, Wellington, NZ cell technologies which, despite their and Bernstein, B.E., “Reconstructing and relative immaturity, already show exciting Reprogramming the Developmental Hierarchy Dr Shalek’s work has been multidisciplinary, and paradigm- shifting results, and which of Glioblastoma,” Cell, 157, 580, (2014). drawing from chemistry, physics, and also serve as an important reminder of the Lohr, J.G., Adalsteinsson, V.A., Cibulskis nanotechnology to conceive of new high- care that must be taken when interpreting K, Choudhury, A.D., Rosenberg, M., Cruz- Gordillo, P. Francis, J., Zhang, C.Z., Shalek, resolution tools for the investigation and fi ndings at the cell population level. Soon, A.K., Satija, R., Trombetta, J.J., Lu, D., manipulation of cells and cell populations. the trees will no longer hide the forest. Tallapragada, N., Tahirova, N., Kim, S., From embryonic stem cells to immune Blumenstiel, B, Sougnez, C., Lowe, A., Wong, cells through tumour cells and neurons, Dr Dr Shalek has recently been appointed as B., Auclair, D., Van Allen, E.M., Nakabayashi, Shalek and collaborators have been at the assistant professor at the MIT Chemistry M., Lis, R.T., Lee, G.S.M., Li, T., Chabot, M.S., cutting edge of understanding fi ne, single- Department, where he will continue his Ly, A., Taplin, M.E., Clancy, T.E., Loda, M., cell transcriptional processes and variability work on new nanotech and chemical biology Regev, A., Meyerson, M., Hahn, W.C., Kantoff, that until recently were only observable at technologies that will aid in understanding P.W., Golub, T.R., Getz, G., Jesse S. Boehm, J., the population level. cell heterogeneity, cell-to- cell interactions Love, J.C., “Whole exome sequencing of CTCs as a window into metastatic prostate cancer,” and cell ensemble decision-making, in Nature Biotechnology, 32, 479, (2014). This has forced the revision of some both healthy and diseased states. This will Shalek, A.K., Satija, R., Shuga, J., Trombetta, ingrained pre-conceptions and mental lead to a more integrated view on how J.J., Lu, D., Gennert, D., Chen, P., Gertner, constructs used in, amongst other fi elds, cells collectively perform systems-level R.S., Gaublomme, J.T., Yosef, N., Schwartz, immunology. Indeed, as their single- cell functions. S., Fowler, B., Weaver, S., Wang, J., Wang, X., transcriptomics experiments have shown, Ding, R., Raychowdhury, R., Friedman, N., immune cells present a much higher Selected publications in the last 3 years: Hacohen, N., Park, H., May, A.P., and Regev, diversity of responses to stimuli than Robinson, J.T., Jorgolli, M., Shalek, A.K., A., “Large-Scale Single-Cell RNA-Seq Reveals previously thought – be it in the fraction of Yoon, M.H., Gertner, R.S., and Park, H., Strategies for Regulating Cell-to-Cell Dynamic Variability through Paracrine Signaling,” responding cells, the level of response, or “Vertical Nanowire Electrode Arrays as a Nature, 510, 363, (2014). the temporal and spatial dynamics thereof. Scalable Platform for Intracellular Interfacing to Neuronal Circuits,” Nature Nanotech. 7, Patel, A.P., Tirosh, I, Trombetta, J.J., Shalek, As such, even the most “pure” cell- surface- 180, (2012). A.K., Gillespie, S.M., Wakimoto, H., Cahill, marker- sorted population of immune Gat-Viks, I., Chevrier, N., Wilentzik, R., D.P., Nahed, B.V., Curry, W.T., Martuza, R.L., cells may potentially present wildly Eisenhaure, T. Raychowdhury, R., Steuerman, Louis, D.N., Rosenblatt-Rosen, O., Suvà, M.L., varying reactions to immune challenges, a Y., Shalek, A.K., Hachohen, N., Amit,, I., and Regev, A., and Bernstein, B.E., “Single Cell heterogeneity that is important at the system Regev, A., “Deciphering Molecular Circuits from RNA-seq highlights intratumoral heterogeneity level to ensure rapid and robust responses Genetic Variation Underlying Transcriptional in primary glioblastoma,” Science, 344, 1396, (or non-responses) to stimuli. Even a Responsiveness to Stimuli,” Nature Biotech., (2014). tiny minority sub- population can drive a 31, 342, (2013). Yosef, N., Shalek, A.K., Gaublomme, J.T. , Jin, April H., Lee, Y., Awasthi, A., Wu, C., Karwacz, K., Associate Professor David Masopust Xiao, S., Jorgolli, M., Gennert, D., Satija, R., University of Minnesota, Department of Shakya, A., Lu, D.Y., Trombetta, J.J., Pillai, Microbiology, Minneapolis, Minnesota, M., Ratcliffe, P.J., Coleman, M.L., Bix, M., USA Tantin, D., Hongkun Park, H., Kuchroo, V.K., and Regev, A., “Dynamic Regulatory Network A/Prof. Masopust has confi rmed he will Controlling Th17 Cell Differentiation,” Nature, visit NSW, NZ, Qld and Vic. Further details 496, 461, (2013). to be announced. Shalek, A. K., Satija, R., Adiconis, X., Gertner, Hosted by Thomas Gebhardt, Department of R. S., Gaublomme, J. T., Raychowdhury, R., Microbiology and Immunology, University Schwartz, S., Yosef, N., Malboeuf, C., Gnirke, of Melbourne A., Goren, A., Hacohen, N., Levin, J., Park, H. & Regev, A. Single-cell transcriptomics reveals April/May bimodality in expression and splicing in immune Professor Daniel Altmann cells. Nature 498, 236, (2013). Gifford, C.A., Ziller, M.J., Gu, H., Trapnell, C., Imperial College, London, UK Donaghey, J., Tsankov, A., Shalek, A.K., Kelley, Prof. Altman has confi rmed he will visit D.R., Shishkin, A.A., Issner, R., Zhang, X., Sydney, Brisbane and Townsville. Further Coyne, M., Fostel, J.L., Holmes, L., Meldrim, J., details to be announced. Assistant Professor Alex Shalek Guttman, M., Epstein, C., Park, H., Kohlbacher, Hosted by Natkunam Ketheesan, James O., Rinn, J., Gnirke, A., Lander, E.S., Bernstein, Cook University, Townsville 12 ASI Inc. Newsletter December 2014

May Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Prof. Hai Qi Zhang, Longyan Wu, and Hai Qi. SAP-regulated School of Medicine, Tsinghua University, T cell-APC adhesion and ligation-dependent Beijing, China and -independent Ly108-CD3ζ interactions. Journal of Immunology, 193(8):3860-71, Prof. Hai Qi will be attending the 6th ABCD 2014. – Australian B cell Dialogue meeting on Qi H, Chen X, Chu C, Liu D, Ma W, Wang Y, May 21–22 in Melbourne and will visit Wu L, Yan H, Yan J. Tfh cell differentiation and various branches. Details of the visit to be their function in promoting B-cell responses. announced Adv Exp Med Biol.;841:153-80, 2014 Hosted by Cindy Ma, Garvan Institute, Hai Qi, Dan Liu, Weiwei Ma, Yifeng Wang, Sydney Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014 Junjiao Yang, Yuan Zhang, Pengfei Yuan, Yuexin Zhou, Changzu Cai, Qingpeng Ren, Dingqiao Wen, Coco Chu, Hai Qi, and Wensheng Wei. Complete decoding of TAL effectors for DNA recognition. Cell Research, 24:628-631, 2014 Xindong Liu, Xin Chen, Bo Zhong, Yaoqi Professor Dirk Busch Alan Wang, Xiaohu Wang, Fuliang Chu, RozaNurieva, Xiaowei Yan, Ping Chen, Research Foundation scholarship gave him Laurens van der Flier, Hiroko Nakatsukasa, the opportunity to study under Prof. Eric SattvaNeelapu, Wanjun Chen, Hans Clevers, Pamer at Yale University (1996-1999). He Qiang Tian, Hai Qi, Lai Wei, and Chen Dong. qualifi ed as a lecturer in 2003 and completed Transcription factor Achaete-Scute homologue his residency in medical microbiology and 2 initiates T follicular helper cell development. epidemiology of infection (2005) at TUM. Nature, 507:513-518, 2014 Prof. Busch heads up the “Antigen-Specifi c Hai Qi, Xin Chen, CoCo Chu, Peiwen Lu, Immunotherapy” clinical co-operation Professor Hai Qi Heping Xu, and Jiacong Yan. Follicular T- helper cells: controlled localization and cellular group (Helmholtz Zentrum München and “Operation of the immune system critically interactions. Immunology & Cell Biology, TUM) and the IAS focus group “Clinical depends on highly dynamic intercellular 92:28-33, 2014. Cell Processing and Purifi cation”. He has communication among multiple cell types, Seung Goo Kang, Wen-Hsien Liu, Peiwen Lu, held the position of director of TUM’s frequently in the form of physical cell-cell Hyun Yong Jin, Hyung W Lim, Jovan Shepherd, Institute for Medical Microbiology, interactions. Germinal centers (GCs) are Daniel Fremgen, Eric Verdin, Michael B A Immunology and Hygiene since 2009. Oldstone, Hai Qi, John R Teijaro, and Changchun highly organized tissue micro-domains Xiao. MiR-17~92 family microRNAs are Professor Busch’s research is focused in which humoral immune memory is critical regulators of T Follicular helper cell generated. I try to understand how: differentiation. Nature Immunology 14:849- on antigen-specifi c T cells and the 57, 2013. development of new technologies to make • cellular interactions critical for GC Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, immune cells usable for diagnostic and cell formation are molecularly orchestrated Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, therapy applications. He has published over • qualitative and quantitative properties Chenguang Xu, Wanli Liu, Lianfeng Zhang, 180 peer reviewed papers making several of such interactions are translated into and Hai Qi. Follicular T-helper cell recruitment seminal contributions to the fi eld which cell fate decisions governed by bystander B cells and ICOS-driven include: understanding T cell fate decisions motility. Nature 496:523-527, 2013. • lymphoid tissues and GC micro-domains upon activation, understanding how Hai Qi. From SAP-less T cells to helpless B heterogeneity of T cell effector function are spatiotemporally patterned, and cells and back: dynamic T-B interactions in • such patterns facilitate productive yet germinal center development. Immunological is regulated and contributes to immune prevent unwanted immune activation. Reviews 247:24-35, 2012. protection and more recently how T cells can be utilized for immunotherapy. Prof. To approach these questions, we utilize Second Semester Busch conducts research into infection genetic, biochemical, cell biological, live Prof. Dirk Busch immunology with the goal of identifying cell imaging, and intravital 2-photon tissue Technische Universität München, therapeutically useful defense mechanisms. imaging methods.” Germany His work centres on antigen-specifi c T cells Details of the visit to be announced and the development of new technologies Selected publications in the last 5 years: Hosted by Steven Turner, University of to make immune cells usable for diagnostic Dan Liu, Heping Xu, Changming Shih, Zurong Melbourne, VIC and cell therapy applications. Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi. T-B cell entanglements and ICOSL- Selected publications in the last 5 years: controlled feed-forward regulation of germinal After studying medicine in Mainz and Freiburg (1993) and completing his Graef P, Buchholz VR, Stemberger C, Flossdorf center reaction. Nature, 2014 Oct 15. doi: M, Henkel L, Schiemann M, Drexler I, Höfer doctorate (1993), Prof. Busch commenced 10.1038/nature13803. T, Riddell SR, Busch DH. Serial transfer of Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, his clinical training in infectious pediatrics single-cell-derived immunocompetence reveals Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei (Würzburg, 1993-1996). A German stemness of CD8(+) central memory T cells.

13 ASI Inc. Newsletter December 2014

Immunity. Jul 17;41(1):116-26, 2014. “My overall research interest is to develop Disease. PLoS One. 2013 PMID: 24040360 Stemberger et al., Lowest numbers of primary translational disease intervention strategies Fouchier RA, Kawaoka Y, Cardona C, Compans CD8+ T cells can reconstitute protective for important human pathogens and RW, García-Sastre A, Govorkova EA, Guan Y, immunity upon adoptive immunotherapy. emerging infectious diseases of zoonotic Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith Blood, pii: blood-2013-12-547349, 2014. origin. My labs investigate the mechanisms Nuemann et al., Clec12a is an inhibitory receptor DJ, Steel J, Tompkins SM, Topham DJ, Treanor of immunity, the virus-host interface and for uric acid crystals that regulates infl ammation JJ, Tripp RA, Webby RJ, Webster RG. Gain-of- in response to cell death. Immunity. 40:389, disease pathogenesis to infl uenza virus to Function Experiments on H7N9. Science. 2013 2014. understand the dynamics of host response PMID: 23926190 Weissbrich et al. Adoptive immunotherapy: to infection and to provide new strategies Fouchier RA, Kawaoka Y, Cardona C, Compans New assay for the identifi cation of T cells with for resolving disease. I trained in the fi eld RW, García-Sastre A, Govorkova EA, Guan Y, optimal avidity. Oncoimmunology. 2:e26199, of viral immunity studying immune evasion Herfst S, Orenstein WA, Peiris JS, Perez DR, 2013. of adenoviruses with Dr Linda Gooding Richt JA, Russell C, Schultz-Cherry SL, Smith Nauerth et al., TCR-ligand koff rate correlates at Emory University, and then T cell DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG.Gain-of- with the protective capacity of antigen-specifi c immunology and viral immunology with CD8+ T cells for adoptive transfer. Sci Transl Function Experiments on H7N9. Science. 2013 Laureate Professor Peter C. Doherty at St. Med. 5:192ra87, 2013. PMID: 23926190 Buchholz et al., Disparate individual fates Jude Children’s Research. Subsequently, I Fouchier RA, Kawaoka Y, Cardona C, Compans compose robust CD8+ T cell immunity. Science. led a research team in vaccine studies for RW, Fouchier RA, García-Sastre A, Govorkova 340:630-5, 2013. human viral diseases in the Respiratory EA, Guan Y, Herfst S, Kawaoka Y, Orenstein Neuenhahn and Busch. Whole body analtomy and Enteric Viruses Branch at the CDC, WA, Peiris JS, Perez DR, Richt JA, Russell C, of human T cells. Immunity. 38(1):10, 2013. and now at the Animal Health Research Schultz-Cherry SL, Smith DJ, Steel J, Tompkins Buchholz et al., The origin of diversity: Center (AHRC) at the Univ Georgia which SM, Topham DJ, Treanor JJ, Tripp RA, Webby studying the evolution of multi-faceted CD8+ T is BSL2/BSL3+ biocontainment facility.” RJ, Webster RG. Avian fl u: Gain-of-function cell responses. Cell Mol Life Sci. 69:1585-95., experiments on H7N9. Nature. 2013 PMID: 2012. 23925229 Selected publications in the last 3 years: Verschoor et al., A platelet-mediated system Turner TM, Jones LP, Tompkins SM, Tripp Powell JD, Dlugolenski D, Nagy T, Gabbard J, for shuttling blood-borne bacteria to CD8α+ RA. A Novel Infl uenza Virus Hemagglutinin- Lee C, Tompkins SM, Tripp RA. Polymerase dendritic cells depends on glycoprotein GPIb Respiratory Syncytial Virus (RSV) Fusion Discordance in Novel Swine Infl uenza H3N2v and complement C3. Nat Immunol. 12:1194, Protein Subunit Vaccine against Infl uenza and Constellations Is Tolerated in Swine but Not 2011. RSV. J Virol. 2013 PMID: 23903841 Human Respiratory Epithelial Cells. PLoS Buchholz et al., CD8+ T cell differentiation in Sage LK, Fox JM, Tompkins SM, Tripp RA. One. 2014 Oct 16;9(10):e110264. the aging immune system: until the last clone Subsisting H1N1 Infl uenza Memory Responses Tripp RA, Mark Tompkins S. Antiviral effects standing. Curr Opin Immunol. 23:549, 2011. are Insuffi cient to Protect from Pandemic H1N1 of inhibiting host gene expression. Curr Top Neuenhahn and Busch. The quest for CD8+ Infl uenza Challenge in C57BL/6 Mice. J Gen Microbiol Immunol. 2015;386:459-77. memory stem cells. Immunity, 31: 702, 2009. Virol. 2013 PMID: 23580424 Perwitasari O, Johnson S, Yan X, Howerth Fouchier RA, García-Sastre A, Kawaoka Y, E, Shacham S, Landesman Y, Baloglu E, December Barclay WS, Bouvier NM, Brown IH, Capua McCauley D, Tamir S, Tompkins SM, Tripp I, Chen H, Compans RW, Couch RB, Cox NJ, Prof. Ralph Tripp RA. Verdinexor, a novel selective inhibitor Doherty PC, Donis RO, Feldmann H, Guan Y, Professor and Georgia Research Alliance of nuclear export, reduces infl uenza a virus Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu Chair of Vaccine & Therapeutic Studies, replication in vitro and in vivo. J Virol. 2014 J, Liu X, Lowen A, Mettenleiter TC, Osterhaus University of Georgia, Athens, GA, USA Sep 1;88(17):10228-43. AD, Palese P, Peiris JS, Perez DR, Richt JA, Prof. Ralph Tripp will attend the ASI Fox JM, Sage LK, Poore S, Johnson S, Tompkins Schultz-Cherry S, Steel J, Subbarao K, Swayne conference in Canberra and will visit SM, Tripp RA. Drug analog inhibition of DE, Takimoto T, Tashiro M, Taubenberger JK, indoleamine 2,3-dioxygenase (IDO) activity several branches. Thomas PG, Tripp RA, Tumpey TM, Webby RJ, modifi es pattern recognition receptor expression Webster RG. Transmission studies resume for Details of the visit to be announced and proinfl ammatory cytokine responses early Hosted by Reena Ghildyal, University of avian fl u. Science. 2013 Feb 1;339(6119):520- during infl uenza virus infection. J Leukoc Biol. 1. PMID: 23345603 Canberra, ACT 2014 Sep;96(3):447-52. Bakre A, Mitchell P, Coleman JK, Jones LP, Phan SI, Chen Z, Xu P, Li Z, Gao X, Foster Saavedra G, Teng M, Tompkins SM, Tripp SL, Teng MN, Tripp RA, Sakamoto K, He B. A RA. Respiratory syncytial virus modifi es respiratory syncytial virus (RSV) vaccine based microRNAs regulating host genes that affect on parainfl uenza virus 5 (PIV5). Vaccine. 2014 virus replication. J Gen Virol. 2012 Nov;93(Pt May 23;32(25):3050-7. 11):2346-56. PMID: 22894925 Sage LK, Fox JM, Mellor AL, Tompkins SM, Meliopoulos VA, Andersen LE, Brooks P, Yan Tripp RA. Indoleamine 2,3-dioxygenase (IDO) X, Bakre A, Coleman JK, Tompkins SM, Tripp activity during the primary immune response RA. MicroRNA regulation of human protease to infl uenza infection modifi es the memory genes essential for infl uenza virus replication. T cell response to infl uenza challenge. Viral PLoS One. 2012;7(5) PMID: 22606348 Immunol. 2014 Apr;27(3):112-23. Choi Y, Mason CS, Jones LP, Crabtree J, Jorquera PA, Choi Y, Oakley KE, Powell TJ, Jorquera PA, Tripp RA. Antibodies to the Boyd JG, Palath N, Haynes LM, Anderson LJ, central conserved region of respiratory syncytial Tripp RA. Nanoparticle Vaccines Encompassing virus (RSV) G protein block RSV G protein the Respiratory Syncytial Virus (RSV) G CX3C-CX3CR1 binding and cross-neutralize Protein CX3C Chemokine Motif Induce Robust RSV A and B strains. Viral Immunol. 2012 Professor Ralph Tripp Immunity Protecting from Challenge and Jun;25(3):193-203. PMID: 22551066 14 ASI Inc. Newsletter December 2014

Immunology & Cell Biology Publication of the Year Awards 2013

Two Immunology & Cell Biology Publication of the Year Awards have been established for outstanding publications, submitted by fi rst authors, who are fi nancial members of the Australasian Society for Immunology Inc. in the year of the article’s publication. Competing articles can be an Original Article, Outstanding Observation, Theoretical Article or Brief Communication. The ASI President together with members of the ASI Executive, judge the most outstanding original research articles based on scientifi c excellence. The winner of the Chris and Bhama Parish ICB Publication of the Year Award is awarded a AU$1000 scholarship provided by the Nature Publishing Group and the runner-up is awarded a AU$500 scholarship provided by Thermo Fisher Scientifi c.

An outstanding series of papers were submitted for consideration for the Immunology & Cell Biology Publication of Dr Seyed-Razavi, the recipient of the 2013 the Year Awards by the judging committee. Dr Kristie Jenkins, recipient of the 2013 Chris Thermo Fisher Scientifi c Publication Award The scientifi c excellence of the works was and Bhama Parish ICB Publication of the Year high. It is a great pleasure to announce the Award winners of the awards for 2013: She maintains an intense interest in the innate E3 ubiquitin protein ligase 1 (MUL1) immune response, small RNA biology and the Chris and Bhama Parish ICB Publication interacts with MAVS and catalyzes RIG-I use of transgenic approaches to delineate cell of the Year Award: Kristie Jenkins, Centre post-translational modifi cations to inhibit fate determination during development. for Innate Immunity and Infectious Diseases, RIG-I-dependent cell signaling. Intriguingly, Monash Institute of Medical Research, depletion of MUL1 resulted in increased Dr Yashar Seyed-Razavi’s paper ‘Membrane Monash University, Australia. activation of this pathway, highlighting that nanotubes in myeloid cells in the adult mouse MUL1 is a novel regulator of this pathway, cornea represent a novel mode of immune Thermo Fisher Scientific Publication potentially limiting the collateral damage that cell interaction’, published in January 2013, Award: Yashar Seyed-Razavi, Department might occur during the ‘clean-up’ process is the winner of the Thermo Fisher Scientifi c 2 of Anatomy and Developmental Biology, associated with pathogen clearance. Publication Award for 2013. School of Biomedical Sciences, Monash University, Australia. Dr Jenkins completed her PhD characterizing Dr Seyed-Razavi’s study was completed as chicken Toll-like receptors that might be part of his PhD undertaken with Professor The winning paper by Dr Jenkins is an involved in viral infection. This project, Paul McMenamin and Dr Holly Chinnery Original Article entitled ‘Mitochondrially undertaken collaboratively through the at the School of Biomedical Sciences, localised MUL1 is a novel modulator of University of Melbourne and CSIRO- Monash University. This work focused on antiviral signaling’ and was published in Australian Animal Health Laboratory understanding cell–cell and neuro-immune April 2014.1 In this paper, Dr Jenkins and (Geelong), was sponsored by a Rural interactions in the homeostatic and injured colleagues tease apart the pathway that Industries Research and Development murine cornea. It was discovered that these allows the immune system to detect and Corporation Scholarship. Dr Jenkins interactions could occur through membrane respond to viral infections and to eliminate subsequently took up a postdoctoral position nanotubes that provide a means by which that infection while sparing massive tissue at the Monash Institute of Medical Research intercellular organelle transfer could occur. destruction in the process. A critical arm of the within the Centre for Innate Immunity and In contrast to previous observations, Seyed- antiviral response is launched by the retinoic Infectious Disease where her work focused Razavi et al. observed that cell–cell contact acid-induciblegene I (RIG-I) protein (RIG- on the innate immune response to viruses. was not a requirement for the formation of I), which activates the antiviral response Dr Jenkins is currently a research scientist membrane nanotubes but that these could by viral RNA and then associates with the working within the Genome Engineering be formed de novo in myeloid-derived cells mitochondrial antiviral signaling (MAVS) team at the CSIRO Australian Animal Health found during infl ammation and viral infection protein to induce infl ammatory cytokines. Laboratory in Geelong identifying ways to in the eye. This work elegantly highlighted The team identifi ed that the mitochondrial improve disease resistance and production how the novel nanotubular networks connect traits in poultry. 15 ASI Inc. Newsletter December 2014 the nervous and immune systems to play to support outstanding science and scientists. Notes: an important role in the early stages of the It is hoped that the outstanding quality 1. Jenkins K, Khoo JJ, Sadler A, Piganis R, Wang innate immune response in the mammalian of these awarded publications will also D, Borg NA et al. Mitochondrially localised cornea. Dr Seyed-Razavi is currently a encourage others to consider Immunology MUL1 is a novel modulator of antiviral signaling. postdoctoral fellow at the Schepens Eye & Cell Biology as a key journal for their Immunol Cell Biol 2013; 91: 321–330. 2. Seyed-Razavi Y, Hickey MJ, Kuffová L, Research Institute, Massachusetts Eye and cutting-edge research. McMenamin PG, Chinnery HR. Membrane Ear in Boston, focusing on the interplay nanotubes in myeloid cells in the adult mouse and modulatory role of nerves in the local Gabrielle Belz cornea represent a novel mode of immune and infi ltrating myeloid-derived cells in the Division of Molecular Immunology, cell interaction. Immunol Cell Biol 2013; 91: cornea. Walter and Eliza Hall Institute of Medical 89–95. Research, The award-winning papers of Drs Jenkins Melbourne, Victoria, Australia Editorial published in Immunology & Cell and Seyed-Razavi highlight the excellence Email: [email protected] Biology Volume 92 no. 10, the November/ of the work published in Immunology & Cell December 2014 issue. Biology. My very best congratulations are extended to the awardees on their success. I also thank our sponsors Nature Publishing and Thermo Fisher Scientifi c for continuing

Therapeutic Monoclonal Antibodies to Snake Venom Joint project between BioCSL Ltd and WEHI Immunology

A PhD scholarship is available for the above project.

Aims: Isolate antibody secreting cells to snake venom from hyper-immune horses Generate monoclonal horse anti-venom antibodies using recombinant DNA technology. Characterise for neutralisation and affi nity Determine cross-reactivity amongst snake species Test in venom challenge experiments. Details: Approach will be to isolate ASC from venom-boosted horses, recovering cells that secrete desired antibodies. Individual antibody genes will be recovered and recombinant, monoclonal horse antibody made in vitro. These hMAbs will then be screened for effi cacy in venom neutralisation, in binding to specifi c proteins in the venom and for cross-reactivity to venom from multiple species, ranging from terrestrial to sea snakes. Mouse monoclonal antibodies will be made in parallel and these will be available as adjunct reagents for characterising the hMAbs. Student: Applicants must have an H1 and should major in Immunology. The award consists of a stipend equivalent to an Australian Post-graduate Award and registration as a PhD student at University of Melbourne. Supervisors WEHI: Profs. David Tarlinton, Andrew Lew BioCSL: A/Prof Steve Rockman

Contact: [email protected]; [email protected]

16 ASI Inc. Newsletter December 2014

ASI COUNCILLORS’ NEWS

N.Z. News A.C.T. News Queensland News

The main event of the ACT Branch in the last 2014 Brisbane Immunology Group few months was the annual retreat together Retreat with the NSW branch. As usual, the retreat The BIG Annual Retreat saw 136 was held at Peppers Craigieburn Conference Queensland and interstate immunologists Centre and Resort in Bowral. At the retreat we descend on Mantra Legends at Surfers heard keynote lectures from Lynn Corcoran Paradise on 21–22 August 2014. Sadly the (WEHI), Wolfgang Weninger (Centenary weather did not come to the party for our Institute), Thomas Gebhard (Uni Melbourne) sun-seeking interstate visitors, however In the last few months, NZ ASI has sponsored and David Tscharke (ANU). Besides the the calibre of the speakers, the food and a visit from Professor Nick King to Dunedin. presentations by the invited speakers, we the discussions in the bar into the wee Nick gave a fantastic seminar and also had a had plenty of excellent talks by students hours more than made up for it. chance to interact with both staff and students and postdocs. The judging panel awarded at the University of Otago. the prize for best presentations by Honours One of the highlights of the meeting was students to Rhea Lindell-Innes (Uni Sydney) the Jonathan Sprent Oration by Prof. An overdue congratulations to Dr Laura and the second prize to Rob Wilson (Garvan). Carola Vinuesa. Carola gave us a very Green who won the 2014 Zonta Science The awards for PhD students were given to honest, entertaining and inspiring account Award. This provides Laura with prize money Tessa Campbell (Uni Sydney) and the second of her career trajectory so far. In addition of $15,000, a further $3,000 towards overseas prize to Jin Yan Yap (ANU). The award for the to her many stunning research highlights, travel and a pounamu medal especially best presentation by a postdoc was given to Carola is extremely passionate about designed by Upper Hutt jeweller Neke Moa. Julia Ellyard (ANU). This award was kindly supporting and promoting women in There was also immunology success at the sponsored by Jomar Bioscience. research and her discussion on practical NZ Society for Oncology annual scientifi c ways this can be achieved was inspiring meeting – PhD student Andy Highton won I also would like to thank the many to us all, but particularly the female early/ the student award for lab-based research for people who helped organize the event, mid career researchers. We were also very his work on vaccinating against colorectal particularly Yogesh Jeelall, Marcel Batten privileged to hear from Liz Hartland on Fas cancer. (NSW Councillor) for always answering signalling in gut infection, Ian Cockburn my questions, and Maria Fernandez for on Live cell imaging of T cell responses We have two major upcoming events – the organizing the judging and, of course, to plasmodium, Cindy Ma on Hyper IgE Gut Health Network Satellite Meeting of the all the judges. Lastly, I want to thank our syndrome and Katherine Kedzierska on NZ Society for Gastroenterology, featuring generous sponsors Becton Dickinson, Jomar Immunity to new strains of infl uenza virus. Professor Charles Mackay. In addition, the Bioscience, Miltenyi, Australian Biosearch, The “hot topic” of RIPK1 and necroptosis 2015 NZ ASI annual meeting will be held Life Technologes and Sigma Aldrich was covered with an excellent presentation in Auckland July 3–5, and the organizing – without their support this meeting would by John Silke. Back on the agenda for this committee is chaired by Dr Ries Langley not have been possible. year was the BIG ICON lecture, awarded ([email protected]). to a Queensland immunologist who has Anselm Enders substantially contributed to the discipline. Congratulations to Jo Roberts, who will be Councillor This year’s worthy recipient was Prof. taking over as Editor of the ASI newsletter in Geoff Hill from QIMR Berghofer, who 2015, it’s great to have some more NZ input epitomised this award with a beautiful into ASI. Finally, Anne LaFlamme (previous bench-to-bedside translational story NZ Councillor) has organized our offi cial describing the role of IL-6 in GVHD. NZ ASI logo (above). There were also many excellent Roslyn Kemp presentations by local speakers and the Councillor ASI Secretariat high quality of the postgraduate and ECR PO Box 7108, sessions made judging a diffi cult task. Upper Ferntree Gully,Vic. 3156 Congratulations to Marcela Montes de Australia Oca (QIMR Berghofer) who was awarded Tel: +61 3 9756 0128 the prize for the best postgraduate student Fax: +61 3 9753 6372 presentation and Ran Wang (Mater Email: [email protected] Research-UQ) who won both the poster prize and the draw for students who asked questions during the meeting.

17 ASI Inc. Newsletter December 2014

Far North Queensland immunologists also Honours Presentation), Duncan McKenzie Enzo Life Sciences, Sapphire Bioscience, had a strong presence at the meeting and the (Best RA Presentation) and Tessa Gargett Jomar, Uni SA, VWR, Olympus, ELISA ASI Queensland branch was pleased to be (Best Early Career Researcher Presentation). Kits, John Morris, ACRF Cancer Genomics able to provide travel bursaries to students There were also plenty of opportunities for Facility, Eppendorf, Scientifi x, Promega, and ECRS- Sandip Kamath, Margaret interaction between the delegates and invited Geneworks, BD Biosciences, Robinson Jordan, Xuyen Dinh and Adrian Gemiarto, speakers. After some free time to explore the Research Institute, Sigma, Adelab Scientifi c, to support their attendance. German village of Hahndorf, the delegates MicroAnalytics Genesearch, Epitope reconvened for a ‘blind wine tasting’ Technologies, Thermofi sher and Australian A big thankyou to all of the organising supported by the generous donation of wine Biosearch. committee – Rajiv Khanna, Matt Sweet, Ray by O’Leary Walker Wines and Murray Street Steptoe, Alejandro Lopez, Andreas Lopata, Vineyards. This was followed by the retreat Finally, we would like to once again especially Danielle Stanisic, Jennifer Freeman, Ken dinner at the German Arms Hotel. thank The Hospital Research Foundation Loh, Connor O’Meara, Sumaira Hasnain which provided the most substantial support and especially Mandie Quince, and also I would like to thank the AIR-10 organizing for the second year in a row with their to our invited speakers, sponsors and local committee members, Susan Christo, Natalie sponsorship of lunch on both days and the participants who all contributed to making Stevens, Erin Lousberg, Nicholas Hauschild, retreat dinner. Without the generous fi nancial this such a fun and interactive meeting. Shamika Moore, Natasha Kolesnikoff, support of all of our sponsors the event each Anita Kral, Houng Taing, Tessa Gargett year could not be held. Kristen Radford and Iain Comerford, for all of their hard Councillor work and enthusiasm for the meeting. Also Cara Fraser a BIG thank you to all of our sponsors, Councillor

S.A./N.T. News

10th Adelaide Immunology Retreat (AIR- 10) 2014 Report Now in its 10th year, the Adelaide Immunology Retreat (AIR) for PhD students, Honours students and research assistants has continued to grow and was once again a great success. This year we extended the scope of the retreat to include a session dedicated to Early Career Researchers which we hope to continue in future years. The retreat was held at The Old Mill, Hahndorf on 15 and 16 August and was opened by our national invited speaker, Professor David Tarlington (WEHI, Group photo at The Old Mill, Hahndorf, SA Vic). Prof. Tarlington shared with us his personal scientifi c journey in his presentation ‘Making Memories for a Lifetime’. On the second day of the retreat our local speaker Professor Sarah Robertson (Director, The Robinson Research Institute) presented her work on the fascinating relationship between the immune system and pregnancy. The high calibre of presentations did not end there, with excellent talks by Early Career Researchers, Honours students, PhD students, and research assistants covering a diverse range of topics which included reproductive immunology, vaccination, allergy, neurobiology and sepsis to name a few. Overall the standard of the presentations was exceptional.

Congratulations go to the following Prize winners LtoR: Natalie Stevens (Question Prize); Nicole Wittwer (Question Prize); Kate award recipients: Kate Parham (Best PhD Parham (Best PhD Presentation); Tessa Gargett (Best Early Career Researcher Presentation); Presentation), Ernesto Hurtado (2nd prize, Ernesto Hurtado (2nd prize PhD Presentation); Erin Andrew (Best Honours Presentation); Duncan McKenzie (Best RA Presentation); Wouter Tonnis (3rd prize PhD Presentation); Invited PhD Presentation), Wouter Tonnis (3rd National Speaker, Prof. David Tarlignton; SA/NT State Councillor, Dr Cara Fraser prize, PhD Presentation), Erin Andrew (Best

18 ASI Inc. Newsletter December 2014

Victorian News Meredith O’Keeffe, for putting together such a strong program and well-organised meeting. Sustaining A big thanks also goes to the sponsors of this meeting for providing essential Membership In September, the IgV hosted its Annual support, but also for their interactions and ASI Inc acknowledges the Retreat at the Novotel Forest Resort presentations. support of the following in Creswick. The meeting was a great sustaining members: success, with many outstanding talks in Please stay tuned for the announcement of a vibrant and relaxed atmosphere. This the 2015 dates for the next Retreat, which is • Abcam Australia program included a fascinating talk by Prof shaping up to be a big one ahead of the 2016 • ARC Centre for Excellence Mariapia Degli-Esposti from the University ICI conference (when there will be no IgV in Advanced Molecular of Western Australia on recently published Retreat or ASI Annual Conference). It will Imaging work defi ning unexpected roles for NK be an “all-in” affair, with invited national • BD Biosciences cells in autoimmune pathology. As always, and international speakers, so make sure • ELISAkit.com a highlight of the Retreat was the high you come along! • Jomar Bioscience calibre of the presentations from students • Miltenyi Biotec Australia and early-career postdoctoral researchers. We are all looking forward to a great ASI • Stemcell Technologies Inc In an extremely competitive fi eld, student Annual Meeting in Wollongong, shortly prizes were awarded to Nick Gherardin and after which, the Visiting Speaker Program Tim Johanson and the postdoctoral prize will bring Prof Peter Ghazal to Melbourne went to Christoph Thelemann. Another for a talk on 8th December. These events are highlight was the trivia night. Everyone sure to end the year off on a high note, with had a ball, especially ASI President, Dale great opportunities to see some of the best Godfrey, who demonstrated an amazing immunology research on offer. breadth of knowledge (just ask him about Miss Tessmacher). Congratulations to the Daniel Gray organisers of this Retreat, in particular Councillor

SPF MICE AND RATS CUSTOMISED BREEDING MAINTENANCE OF STRAINS IMPORT AND EXPORT CRYOPRESERVATION

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19 ASI Inc. Newsletter December 2014 TRAVEL AWARD CONFERENCE REPORTS

EMBO Conference on Innate Lymphoid Cells 29 September – 1 October 2014, Paris, France Cyril Seillet Walter & Eliza Hall Institute of Medical Research, Melbourne, Victoria

Thanks to the Postdoctoral International I then visited the CPTP institute in Toulouse Travel Awards form the ASI, I had the to give a seminar on the “The transcriptional privilege to attend to one of the most exciting regulation of the innate lymphoid cells”. It conferences I have been to during my young was a good opportunity to present the work career. The EMBO Conference on Innate I have done during my post-doc at WEHI, Lymphoid Cells (ILC) that was held in Paris and initiate new collaborations with teams from September 29 to October 1 was the fi rst interested in investigating the role of these international meeting gathering all leading new cell subsets in others pathological researchers of this emerging fi eld. The study models. of ILC is a budding fi eld in immunology, with a major impact on our understanding I can’t thank the ASI enough for supporting of the early events occurring during an this trip, as attending this congress was a immune response. These cells are, moreover, unique opportunity to meet the incipient highlighting the importance of immune cells, ILC community and see the bigger picture not only to protect the organism against of ILC research. pathogens, but also at steady state for the proper tissue homeostasis. This congress was a unique opportunity to gather all major players in the research area and discuss about recent advances and the future directions of an exponentially growing fi eld.

The scientifi c program was ambitious and had been divided into three main parts. The fi rst part of the congress was dedicated to the development, where a major outbreak has been done recently with the identifi cation of a common precursor for all ILC. The second part focussed on the role of the ILC in tissue homeostasis and integrity. Finally the last day concentrated on the activation and function of the ILC during infl ammation. The end of the meeting was the occasion to consider the opportunity to reconvene this meeting every 2-3 years. The next one should be in England, but Australia is already in the running to organize the third conference Participants at the EMBO Conference, Paris that will without doubt become bigger and bigger. Beside the scientifi c aspect of the meeting, the venue was great at the Pasteur ICB & CTI Online Manuscript Submission Institute, and at lunch we savored delicious French cuisine. Online manuscript submission for Immunology & Cell Biology and Clinical & Translational Immunology now available via: http://mts-icb.nature.com/ http://mts-cti.nature.com/

All manuscript submissions to ICB and CTI should in future be made online via these websites to speed up the reviewing and acceptance of manuscripts.

Gabrielle Belz, Editor-in-Chief Immunology & Cell Biology Clinical & Translational Immunology

20 ASI Inc. Newsletter December 2014

Investigating disease progression in amyotrophic lateral sclerosis: A window into life at the University of British Columbia, Vancouver July – November 2014 Rachael Bartlett Illawarra Health and Medical Research Institute, University of Wollongong, NSW

I arrived in Canada on a rainy July morning, misfolding of proteins in ALS and proceeded to get lost in both downtown and Alzheimer’s disease, and Vancouver and Stanley Park before the day the development of therapeutics had ended. Things only got better from capable of blocking these processes. there! Vancouver was to become my home During my time there, I made use of from July to November, fi rstly to present systems developed in this laboratory my PhD research on the DAMP (or alarmin) to investigate the possible role extracellular ATP and its receptor P2X7 in of the DAMP receptor P2X7 in neurodegeneration, and secondly to continue propagating misfolding of ALS- my research at the University of British linked superoxide dismutase 1. This Columbia (UBC). research is now well underway, and I will be taking back what Three days after I arrived I had the I’ve learnt to establish these privilege of attending and presenting at techniques in my home laboratory the inaugural conference and workshop on at the Illawarra Health and Medical Molecular Origins of Protein Misfolding and Research Institute (University of Neurodegenerative Disease. This conference Wollongong) and continue this line Rachael working in the lab at UBC was held with sweeping views of downtown of investigation. Vancouver, and covered mechanisms of misfolding, neuroinflammation and New techniques are not the only thing I will This was followed by weeks of rain which, neurodegeneration in diseases such as return home with. In addition, I received if I believe the locals, will continue to fall amyotrophic lateral sclerosis (ALS), some great input on my work, fresh ideas on and off (but mainly on) for the next six Alzheimer’s disease and Parkinson’s disease. and renewed motivation from my peers. months or so! I was lucky enough to hear presentations by Also, I discovered a new-found love of a number of inspiring researchers, including coffee, that my Australian vocabulary was I would like to sincerely thank my host Dr Chris Dobson, Joseph Beckman, Danny at times akin to another language, and that Cashman and the ASI for funding, which Hatters, Neil Cashman and Ted Allison. With the average Canadian does not fi nd squirrels helped to make this amazing adventure only 35 speakers, the majority of whom were as captivating as I do (together with my possible. I will return home with fantastic principle investigators, I was particularly coffee-induced hyperactivity earning me the memories, extra skills, fresh ideas, new honored to be given the opportunity to present nickname Squirrel). I found myself falling in friends and collaborators, and possible my research to this audience. Furthermore, love with the city of Vancouver which, unlike post-doctoral openings. I would encourage with an emphasis on group discussions, this my Australian hometown of Wollongong, any and all fellow PhD students to seek out workshop gave me the opportunity to get has such distinct seasons. I experienced the any opportunity to work in a laboratory to know a number of leading researchers in summer, where the city seemed to come overseas – it is rewarding and inspiring, both the fi eld, all working toward the common alive with people and events, and the aptly personally and professionally. goal of understanding how proteins misfold named fall, where the leaves went from green and neurodegeneration proceeds. Together to vibrant hues of red, orange and yellow. Below: View of downtown Vancouver with organized extracurricular activities, including dinners, hikes, bike rides and fi reworks, these discussions resulted in me receiving some great feedback on my work and making a number of connections which may potentially lead to postdoctoral opportunities.

Following the conference I moved into a basement apartment to begin four months of work in the laboratory of Dr Neil Cashman, a clinical neurologist and neuroscientist based at the Brain Research Centre at UBC. Dr Cashman’s laboratory is largely focused on investigating the role of propagated

21 ASI Inc. Newsletter December 2014

Keystone Symposia: Cell Death Signaling in Cancer and the Immune System 28 October – 2 November, 2014, São Paulo, Brazil Alison West MIMR-PHI Institute of Medical Research, Victoria

In October 2014 I had the enormous privilege became a real phenomena with physiological of traveling to São Paulo, Brazil to attend the relevance. I also learnt a lot about the different Keystone Symposia: Cell Death Signaling types of cell death – apoptosis, necroptosis, in Cancer and the Immune System, thanks necrosis, pyroptosis and autophagy, and it to the ASI International Travel Award. As is was fascinating to hear the arguments about the case for all Keystones, the location was whether or not these modes of death truly spectacular and the science even more so! existed, and if so, did they really matter? Australia’s own Andreas Strasser and David The conference was held at the Casa Grande Huang were amongst the heavy-hitting Hotel, a 5-star resort in the beachside suburb presenters which included Doug Green, of Guarujá. The view from the conference Vishva Dixit, Scott Lowe, David Andrews, centre was a beautiful 6km long white beach, Thirumala-Devi Kanneganti, Seamus Martin complete with coconut trees, beach vendors and Shigekazu Nagata to name a few. selling coconuts and ice cream and umbrellas as far as the eye could see. The beach was Overall it was a fantastic, ‘boutique’ packed everyday, but considering the greater conference with a small number of delegates. São Paulo region is home to almost as many The poster sessions were lively and many people as in all of Australia, it wasn’t so busy! collaborations were formed during the course The weather was perfect which helped the of the meeting. I would like to thank ASI for very global conference delegates get over the opportunity to present my work at this their jetlag quickly, and also facilitated great The data presented at the meeting was cutting conference and I look forward to the next pool-side networking – it was common to edge and inspiring. The majority of data was update on this fi eld! see impromptu meetings held on deck chairs unpublished, and it was refreshing to see so with a laptop in one hand and a cocktail in many groups around the world challenging the other. During the conference we had the the dogma of traditional cell death signaling chance to experience Brazilian hospitality pathways. It became apparent that there with a boat tour of the huge harbor and a were no rules for the process of cell death, trip to a fascinating fortress overlooking the and that each cell was wired to respond ocean. There were also a few caipirinha’s (the in highly selective ways to each stimulus. national drink of Brazil) enjoyed on the last The quality of the data was so high that the night along with a live samba band! counterintuitive, non-canonical signaling pathways previously hypothesised suddenly

Contributions sought for the ASI Newsletter You could win $200 !! Deadline for the next issue: 1st February 2015

Please email your contributions to the Secretariat by the above date. [email protected]

22 ASI Inc. Newsletter December 2014 FIMSA “Frontiers in Immune Modulation”

FIMSA2015 aims to facilitate interactions between members of its societies and to exchange knowledge in basic and clinical immunology to advance the science of immunology in the Asia-Pacific region. The congress will bring together scientists from the region for this purpose.

6th Congress of the FIMSA 30 June - 3July 2015 (Federation of Immunological Societies of Asia Oceania) Sands Expo and Convention Centre, Singapore

Keynote Speaker: Tasuku HONJO, Japan

Confirmed Speakers: Gabrielle BELZ, Australia Stefan KAUFMANN, Germany Su BING, China Bernard MALISSEN, France Xuetao CAO, China Diane MATHIS, United Kingdom Shubhada CHIPLUNKAR, India James McCLUSKEY, Australia Gennaro DE LIBERO, Singapore Caetano REIS e SOUSA, United Kingdom Sidonia FAGARASAN, Japan Koyasu SHIGEO, Japan Nick GASCOIGNE, Singapore Charles D SURH, South Korea Florent GINHOUX, Singapore Zhigang TIAN, China William (Bill) HEATH, Australia Carola VINUESA, Australia

Organised by: For more information, please visit www.sgsi.org.sg or email to [email protected]

23 ASI Inc. Newsletter December 2014

Publications List Congratulations to ASI members who have published their following work in the last three months

Anyaegbu CC, Lake RA, Heel K, Robinson BW, Fisher Dasari P, Sharkey DJ, Noordin E, Glynn DJ, Honda-Okubo Y, Kolpe A, Li L, Petrovsky N. A single SA. Chemotherapy enhances cross-presentation Hodson LJ, Chin PY, Evdokiou A, Robertson SA, immunization with inactivated H1N1 infl uenza of nuclear tumor antigens. PloS one 2014; 9(9): Ingman WV. Hormonal regulation of the cytokine vaccine formulated with delta inulin adjuvant e107894. microenvironment in the mammary gland. Journal (Advax) overcomes pregnancy-associated immune of reproductive immunology 2014. Bartlett R, Stokes L, Sluyter R. The P2X7 receptor suppression and enhances passive neonatal channel: recent developments and the use of P2X7 de Araujo AD, Hoang HN, Kok WM, Diness F, Gupta protection. Vaccine 2014; 32(36): 4651. antagonists in models of disease. Pharmacological P, Hill TA, Driver RW, Price DA, Liras S, Fairlie DP. Howson LJ, Morris KM, Kobayashi T, Tovar C, Kreiss reviews 2014; 66(3): 638. Comparative alpha-helicity of cyclic pentapeptides A, Papenfuss AT, Corcoran L, Belov K, Woods GM. in water. Angewandte Chemie 2014; 53(27): 6965. Identifi cation of dendritic cells, B cell and T cell Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet subsets in Tasmanian devil lymphoid tissue; evidence AC, Ruutu M, Kikly K, Wang R, Tseng HW, Thomas GP Eckle SB, Birkinshaw RW, Kostenko L, Corbett AJ, for poor immune cell infi ltration into devil facial et al. Interleukin-23 mediates the intestinal response McWilliam HE, Reantragoon R, Chen Z, Gherardin tumors. Anatomical record 2014; 297(5): 925. to microbial beta-1,3-glucan and the development of NA, Beddoe T, Liu L et al. A molecular basis spondyloarthritis pathology in SKG mice. Arthritis underpinning the T cell receptor heterogeneity of Hutchinson AT, Jones DR, McCauley Winter P, Tangye & rheumatology 2014; 66(7): 1755. mucosal-associated invariant T cells. The Journal of SG, Raison RL. Cell membrane associated free kappa experimental medicine 2014; 211(8): 1585. light chains are found on a subset of tonsil and in Bhattacharyya T, Ayandeh A, Falconar AK, Sundar vitro-derived plasmablasts. Human immunology S, El-Safi S, Gripenberg MA, Bowes DE, Thunissen Ellyard JI, Jerjen R, Martin JL, Lee A, Field MA, Jiang 2014; 75(9): 986. C, Singh OP, Kumar R et al. IgG1 as a Potential SH, Cappello J, Naumann SK, Andrews TD, Scott HS et Biomarker of Post-chemotherapeutic Relapse in al. Whole exome sequencing in early-onset cerebral Jones MW, Dearnley MK, van Riessen GA, Abbey B, Visceral Leishmaniasis, and Adaptation to a Rapid SLE identifi es a pathogenic variant in TREX1. Putkunz CT, Junker MD, Vine DJ, McNulty I, Nugent Diagnostic Test. PLoS neglected tropical diseases Arthritis & rheumatology 2014. KA, Peele AG et al. Rapid, low dose X-ray diffractive 2014; 8(10): e3273. Fernandez CS, Kelleher AD, Finlayson R, Godfrey imaging of the malaria parasite Plasmodium falciparum. Ultramicroscopy 2014; 143: 88. Brennan RM, Burrows JM, Elliott T, Neller MA, Gras DI, Kent SJ. NKT cell depletion in humans during S, Rossjohn J, Miles JJ, Burrows SR. Missense single early HIV infection. Immunology and cell biology Jones MW, van Riessen GA, Abbey B, Putkunz CT, nucleotide polymorphisms in the human T cell 2014; 92(7): 578. Junker MD, Balaur E, Vine DJ, McNulty I, Chen receptor loci control variable gene usage in the T Fisher SA, Cleaver A, Lakhiani DD, Khong A, Connor B, Arhatari BD et al. Whole-cell phase contrast cell repertoire. British journal of haematology 2014; T, Wylie B, Lesterhuis WJ, Robinson BW, Lake RA. imaging at the nanoscale using Fresnel coherent 166(1): 148. Neoadjuvant anti-tumor vaccination prior to surgery diffractive imaging tomography. Scientifi c reports 2013; 3: 2288. Bunting MD, Comerford I, Kara EE, Korner H, McColl enhances survival. Journal of translational medicine SR. CCR6 supports migration and differentiation of a 2014; 12: 245. Judd LM, Chalinor HV, Walduck A, Pavlic DI, Dabritz subset of DN1 early thymocyte progenitors but is not Good-Jacobson KL, Chen Y, Voss AK, Smyth GK, J, Dubeykovskaya Z, Wang TC, Menheniott TR, Giraud required for thymic nTreg development. Immunology Thomas T, Tarlinton D. Regulation of germinal center AS. TFF2 defi ciency exacerbates weight loss and and cell biology 2014; 92(6): 489. responses and B-cell memory by the chromatin alters immune cell and cytokine profi les in DSS colitis and this can not be rescued by wild type bone marrow. Cantacessi C, Giacomin P, Croese J, Zakrzewski M, modifi er MOZ. Proceedings of the National Academy American journal of physiology. Gastrointestinal and Sotillo J, McCann L, Nolan MJ, Mitreva M, Krause of Sciences of the United States of America 2014; liver physiology 2014: ajpgi 00172 2014. L, Loukas A. Impact of experimental hookworm 111(26): 9585. infection on the human gut microbiota. 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24 ASI Inc. Newsletter December 2014

Kumar R, Singh OP, Gautam S, Nylen S, Sundar S. of the American Society of Transplantation and the anti-hemagglutinin antibodies. PloS one 2014; 9(7): Enhanced expression of Toll-like receptors 2 and American Society of Transplant Surgeons 2014; e102618. 4, but not 9, in spleen tissue from patients with 14(11): 2478. Reboul CF, Whisstock JC, Dunstone MA. A new visceral leishmaniasis. Parasite immunology 2014; Mueller SN, Zaid A, Carbone FR. Tissue-resident T model for pore formation by cholesterol-dependent 36(12): 721. cells: dynamic players in skin immunity. Frontiers cytolysins. PLoS computational biology 2014; 10(8): Kwa MQ, Nguyen T, Huynh J, Ramnath D, De Nardo D, in immunology 2014; 5: 332. e1003791. Lam PY, Reynolds EC, Hamilton JA, Sweet MJ, Scholz Nasr N, Lai J, Botting RA, Mercier SK, Harman AN, Rehaume LM, Mondot S, Aguirre de Carcer D, Velasco GM. Interferon regulatory factor 6 differentially Kim M, Turville S, Center RJ, Domagala T, Gorry PR J, Benham H, Hasnain SZ, Bowman J, Ruutu M, Hansbro regulates Toll-like receptor 2-dependent chemokine et al. Inhibition of two temporal phases of HIV-1 PM, McGuckin MA et al. ZAP-70 genotype disrupts gene expression in epithelial cells. The Journal of transfer from primary Langerhans cells to T cells: the relationship between microbiota and host, leading biological chemistry 2014; 289(28): 19758. the role of langerin. Journal of immunology 2014; to spondyloarthritis and ileitis in SKG mice. Arthritis La Gruta NL, Turner SJ. T cell mediated immunity 193(5): 2554. & rheumatology 2014; 66(10): 2780. to infl uenza: mechanisms of viral control. Trends in Need EF, Atashgaran V, Ingman WV, Dasari P. Hormonal Reid RC, Yau MK, Singh R, Lim J, Fairlie immunology 2014; 35(8): 396. regulation of the immune microenvironment in the DP. Stereoelectronic effects dictate molecular Lam RS, O’Brien-Simpson NM, Lenzo JC, Holden JA, mammary gland. Journal of mammary gland biology conformation and biological function of heterocyclic Brammar GC, Walsh KA, McNaughtan JE, Rowler DK, and neoplasia 2014; 19(2): 229. amides. Journal of the American Chemical Society Van Rooijen N, Reynolds EC. Macrophage depletion Nystrom SN, Bourges D, Garry S, Ross EM, van Driel 2014; 136(34): 11914. abates Porphyromonas gingivalis-induced alveolar IR, Gleeson PA. Transient Treg-cell depletion in adult Rogers GB, Kozlowska J, Keeble J, Metcalfe K, Fao bone resorption in mice. Journal of immunology 2014; mice results in persistent self-reactive CD4 T-cell M, Dowd SE, Mason AJ, McGuckin MA, Bruce KD. 193(5): 2349. responses. European journal of immunology 2014. Functional divergence in gastrointestinal microbiota Lang PA, Meryk A, Pandyra AA, Brenner D, Brustle Odobasic D, Ghali JR, O’Sullivan KM, Holdsworth in physically-separated genetically identical mice. A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P SR, Kitching AR. Glomerulonephritis Induced by Scientifi c reports 2014; 4: 5437. et al. Toso regulates differentiation and activation Heterologous Anti-GBM Globulin as a Planted Ross EM, Bourges D, Hogan TV, Gleeson PA, van Driel of infl ammatory dendritic cells during persistence- Foreign Antigen. Current protocols in immunology IR. Helios defi nes T cells being driven to tolerance prone virus infection. Cell death and differentiation / edited by John E. Coligan ... [et al.] 2014; 106: 15 in the periphery and thymus. European journal of 2014. 26 1. immunology 2014; 44(7): 2048. Liddicoat DR, Kyparissoudis K, Berzins SP, Cole Olson MR, Seah SG, Edenborough K, Doherty PC, Lew Singhal G. Immunobiology of Spermatozoa: A TJ, Godfrey DI. The glucocorticoid receptor AM, Turner SJ. CD154+ CD4+ T-cell dependence Review. Reproductive Biology Insights 2014; 7: 17. 1A3 promoter correlates with high sensitivity for effective memory infl uenza virus-specifi c CD8+ to glucocorticoid-induced apoptosis in human Singhal G, Jaehne EJ, Corrigan F, Toben C, Baune BT. T-cell responses. Immunology and cell biology 2014; lymphocytes. Immunology and cell biology 2014; Infl ammasomes in neuroinfl ammation and changes 92(7): 605. 92(10): 825. in brain function: a focused review. Frontiers in Osborne B, Yao TW, Wang XM, Chen Y, Kotan LD, neuroscience 2014; 8: 315. Lim YC, Roberts TL, Day BW, Stringer BW, Kozlov S, Nadvi NA, Herdem M, McCaughan GW, Allen JD, Fazry S, Bruce ZC, Ensbey KS, Walker DG, Boyd AW Smyth MJ, Ngiow SF, Teng MW. Targeting regulatory Yu DM et al. A rare variant in human fi broblast et al. Increased sensitivity to ionizing radiation by T cells in tumor immunotherapy. Immunology and activation protein associated with ER stress, loss targeting the homologous recombination pathway in cell biology 2014; 92(6): 473. of enzymatic function and loss of cell surface glioma initiating cells. Molecular oncology 2014. localisation. Biochimica et biophysica acta 2014; Soh CL, Giudice A, Jenny RA, Elliott DA, Hatzistavrou Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, 1844(7): 1248. T, Micallef SJ, Kianizad K, Seach N, Zuniga-Pfl ucker JC, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Chidgey AP et al. FOXN1 (GFP/w) reporter hESCs Parish IA, Marshall HD, Staron MM, Lang PA, Brustle Hartland EL et al. Rab8a interacts directly with enable identifi cation of integrin-beta4, HLA-DR, A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ et PI3Kgamma to modulate TLR4-driven PI3K and and EpCAM as markers of human PSC-derived al. Chronic viral infection promotes sustained Th1- mTOR signalling. Nature communications 2014; 5: FOXN1(+) thymic epithelial progenitors. Stem cell derived immunoregulatory IL-10 via BLIMP-1. The 4407. reports 2014; 2(6): 925. Journal of clinical investigation 2014; 124(8): 3455. Macleod BL, Bedoui S, Hor JL, Mueller SN, Russell Sotillo J, Sanchez-Flores A, Cantacessi C, Harcus Petrovsky N. The coming of age of DNA vaccines. TA, Hollett NA, Heath WR, Tscharke DC, Brooks AG, Y, Pickering D, Bouchery T, Camberis M, Tang SC, Current gene therapy 2014; 14(3): 147. Gebhardt T. Distinct APC subtypes drive spatially Giacomin P, Mulvenna J et al. Secreted proteomes of segregated CD4+ and CD8+ T-cell effector activity Pinfold TL, Brown GK, Bettiol SS, Woods GM. Mouse different developmental stages of the gastrointestinal during skin infection with HSV-1. PLoS pathogens Model of Devil Facial Tumour Disease Establishes nematode Nippostrongylus brasiliensis. Molecular & 2014; 10(8): e1004303. That an Effective Immune Response Can be cellular proteomics : MCP 2014; 13(10): 2736. Generated Against the Cancer Cells. 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Pathway-selective antagonism of proteinase immunological evaluation of self-adjuvanting MUC1- Pritchard AL, White OJ, Burel JG, Carroll ML, Phipps activated receptor 2. British journal of pharmacology macrophage activating lipopeptide 2 conjugate S, Upham JW. Asthma is associated with multiple 2014; 171(17): 4112. vaccine candidates. Chemical communications 2014; alterations in anti-viral innate signalling pathways. Tan DB, Fernandez S, Price P, French MA, Thompson 50(71): 10273. PloS one 2014; 9(9): e106501. PJ, Moodley YP. Impaired function of regulatory T- Mittal D, Young A, Stannard K, Yong M, Teng MW, Radcliff FJ, Fraser JD, Proft T. Vaccination with cells in patients with chronic obstructive pulmonary Allard B, Stagg J, Smyth MJ. Antimetastatic effects Streptococcus pyogenes nuclease A stimulates a high disease (COPD). 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25 ASI Inc. Newsletter December 2014

Tribolet L, Cantacessi C, Pickering DA, Navarro S, development, undergoing clinical trials and in Zhang Y, Kinkel S, Maksimovic J, Bandala-Sanchez E, Doolan DL, Trieu A, Fei H, Chao Y, Hofmann A, Gasser current use in melanoma treatment. Expert review Tanzer MC, Naselli G, Zhang JG, Zhan Y, Lew AM, RB et al. Probing of a Human Proteome Microarray of clinical immunology 2014; 10(8): 1107. Silke J et al. The polycomb repressive complex 2 With a Recombinant Pathogen Protein Reveals a Webster KE, Kim HO, Kyparissoudis K, Corpuz TM, governs life and death of peripheral T cells. Blood Novel Mechanism by Which Hookworms Suppress Pinget GV, Uldrich AP, Brink R, Belz GT, Cho JH, 2014; 124(5): 737. B-Cell Receptor Signaling. The Journal of infectious Godfrey DI et al. IL-17-producing NKT cells depend Zhou F, Ciric B, Zhang GX, Rostami A. Immunotherapy diseases 2014. exclusively on IL-7 for homeostasis and survival. using lipopolysaccharide-stimulated bone marrow- Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Mucosal immunology 2014; 7(5): 1058. derived dendritic cells to treat experimental Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler Wong K, Lister NL, Barsanti M, Lim JM, Hammett MV, autoimmune encephalomyelitis. Clinical and NS, Fett C et al. The cellular redox environment Khong DM, Siatskas C, Gray DH, Boyd RL, Chidgey experimental immunology 2014; 178(3): 447. alters antigen presentation. The Journal of biological AP. Multilineage potential and self-renewal defi ne Zuccarino-Catania GV, Sadanand S, Weisel FJ, Tomayko chemistry 2014; 289(40): 27979. an epithelial progenitor cell population in the adult MM, Meng H, Kleinstein SH, Good-Jacobson KL, Turvey ME, Koudelka T, Comerford I, Greer JM, thymus. Cell reports 2014; 8(4): 1198. Shlomchik MJ. CD80 and PD-L2 defi ne functionally Carroll W, Bernard CC, Hoffmann P, McColl SR. Zhang XY, Simpson JL, Powell H, Yang IA, Upham distinct memory B cell subsets that are independent Quantitative proteome profi ling of CNS-infi ltrating JW, Reynolds PN, Hodge S, James AL, Jenkins C, of antibody isotype. Nature immunology 2014; 15(7): autoreactive CD4+ cells reveals selective changes Peters MJ et al. Full blood count parameters for 631. during experimental autoimmune encephalomyelitis. the detection of asthma infl ammatory phenotypes. Journal of proteome research 2014; 13(8): 3655. Clinical and experimental allergy : journal of the Vella LJ, Andrews MC, Behren A, Cebon J, Woods British Society for Allergy and Clinical Immunology K. Immune consequences of kinase inhibitors in 2014; 44(9): 1137.

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