Annual Report
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Annual Report Report 2012 / 2013 2016 stemcellsaustralia.edu.au Abbreviations used throughout this document AIBN Australian Institute for Bioengineering and Nanotechnology ARC Australian Research Council ARMI Australian Regenerative Medicine Institute ASSCR Australasian Society for Stem Cell Research BPA Bioplatforms Australia CCRM Centre for Commercialization of Regenerative Medicine CM Cardiomyocyte CNS Central Nervous System CSIRO Commonwealth Scientific and Industrial Research Organisation GTAC Gene Technology Access Centre IMB Institute of Molecular Biosciences ISSCR International Society for Stem Cell Research MCRI Murdoch Childrens Research Institute MSC Mesenchymal stromal cells NHMRC National Health and Medical Research Council QBI Queensland Brain Institute SCA Stem Cells Australia STEMM Science, Technology, Engineering, Mathematics and Medicine TGA Therapeutic Goods Administration UNSW University of New South Wales UoM University of Melbourne UQ University of Queensland VCCRI Victor Chang Cardiac Research Institute WEHI Walter and Eliza Hall Institute of Medical Research Supported by: Our Partners: Cover Image: Human embryonic stem cells differentiated into ventral midbrain progenitors and maintained in culture as neurospheres. The sphere is stained for TUJ (green) to identify all neurons, and tyrosine hydroxylase (red) to more specifically identify dopamine neurons. Courtesy of Dr Jonathan Niclis (The Florey Institute of Neuroscience and Mental Health). stemcellsaustralia.edu.au 3 STEM CELLS AUSTRALIA ANNUAL REPORT 2016 Contents Message From The Chairman 4 Message From The Program Leader 5 Program Highlights 6 Research Program 12 Theme: Pluripotency and Reprogramming 14 Theme: Neural Regeneration and Repair 15 Theme: Cardiac Regeneration and Repair 16 Theme: Haematopoiesis 17 Education, Ethics, Law and Community Awareness Unit 18 Stemformatics 20 Postgraduate Completions 21 Leadership and Governance 22 Governance Committee 23 Stem Cell Derived Neural Cultures Positive For Scientific Advisory Committee 24 Oligodendrocyte Marker. Courtesy of Ms Claire Cuddy (UoM). Our People 26 Scientific Leadership Group 26 Chief and Partner Investigators 27 Associate Investigators 28 Affiliate Investigators 29 Management Team 30 Platform Technologies and Facilities Teams 31 Early Career Researchers and Students 32 Performance Tables 38 Publications 40 Vision Statement Grants 52 Awards and Appointments 54 To discover how to regulate stem cells Conference and Meeting Participation 56 in order to harness their potential for Community Activities 64 therapeutic purposes and to generate Media Coverage 65 economically valuable biotechnologies. Financial Statement 67 stemcellsaustralia.edu.au 4 STEM CELLS AUSTRALIA ANNUAL REPORT 2016 Message from the Chairman 2016 has seen another year of substantial scientific discoveries from the researchers in Stem Cells Australia (SCA), an Australian Research Council (ARC) Special Research Initiative in Stem Cell Science. These advances have had substantial impact on stem This change also saw Professor Melissa Little appointed cell research at both the national and international level. to the Governance Committee as MCRI’s representative. With over 120 members from four leading Australian I would like to take this opportunity to thank Dr Keith universities and four premier medical research McLean, who stepped down from the Governance institutes, the focus of our interdisciplinary and cross- Committee at the completion of CSIRO’s term, for institutional research has remained on enhancing our his strident support for the SCA initiative from its understanding of the fundamental mechanisms involved inception. We also thank Professor Robyn Ward from in stem cell regulation and differentiation. the University of Queensland (UQ) for her contribution and welcome the new representative for UQ Mr Ian Our laboratory research interests span the use of stem Harris onto the Governance Committee. cells in disease modelling, computational science, blood formation and maintenance of pluripotency, to potential Although CSIRO formally retired, we were pleased applications of stem cells in memory retention, repair that senior CSIRO researchers, Professor Susie Nilsson, of damaged cells following heart attack and cellular Professor David Haylock and Associate Professor solutions for neurological conditions such as multiple Andrew Laslett have continued their links to the SCA sclerosis. initiative by joining as Affiliate Investigators. Within the Haematopoiesis theme we also welcomed Professor In addition to our excellence in research, SCA has also Andrew Elefanty and Dr Samir Taoudi as new leaders sought to lead public debate and discussion about the and thank Professors Doug Hilton and David Haylock for ethical, legal and societal impact of stem cell research – their leadership of this theme since inception of SCA. crucial considerations as we advance the biological and therapeutic applications of our science. Towards the end of 2016 we also learnt that Professor Martin Pera, inaugural Program Leader of the SCA During 2016, the contributions of our researchers have initiative, would be returning to the USA to take-up been recognised by prestigious awards, fellowships a position at the Jackson Laboratory in Bar Harbour, and invitations to present at numerous international Maine where he will continue his research into the and national meetings. Publications have appeared mechanisms that control the growth and fate of in leading peer-reviewed journals and we have been pluripotent stem cells. delighted to see 13 of our PhD students complete their studies and embark on the next stage of their careers. I would like to take this opportunity to thank Martin. Under his leadership, and with the ongoing support Throughout the year, we have created opportunities to of the ARC, SCA has been able to establish an foster collaborations, and importantly to share reports environment that has enabled excellence in stem cell of progress in our research and discuss challenges research to thrive. Martin has also championed training encountered. We held an Annual Retreat for all research and mentoring opportunities for young researchers members and three theme-specific workshops. We and has been a powerful advocate for stem cell science greatly appreciated members of our Scientific Advisory in the broader community. We wish him the best as Committee taking the time to attend and actively he pursues his new role in the USA and look forward participate in our Annual Retreat - especially our to ongoing engagement particularly through the international members who travelled a vast distance to International Society for Stem Cell Research (ISSCR) join us. where he serves as Clerk. This year has also seen a change in Partner It remains a privilege to be associated with the exciting Organisations. With the formal completion of field of stem cell science and in particular this stellar partnership with the Commonwealth Scientific and group of interdisciplinary researchers. I would like to Industrial Research Organisation (CSIRO) at the end of congratulate all members of SCA for their contribution, 2015, we were pleased welcome the Murdoch Childrens dedication and ongoing success. Research Institute (MCRI) as a Partner Organisation in 2016. Professor David de Kretser Chairman, Governance Committee stemcellsaustralia.edu.au 5 STEM CELLS AUSTRALIA ANNUAL REPORT 2016 Message from the Program Leader In 2016, the fifth year of operation of SCA, our research teams continued to expand their outstanding record of contributions to both basic and applied stem cell biology. The 2016 SCA research publications portfolio As we head towards our sixth year of funding, we encompasses a remarkable diversity of topics, can begin to shape our vision of the future. Australian ranging from novel methodology for mobilisation of stem cell research continues to maintain a high hematopoietic stem cells (Susie Nilsson), to modelling international profile, particularly in basic stem cell of an important form of inherited cardiomyopathy biology. While maintaining this momentum, we must (David Elliott), computational analysis of cellular ensure that translational research programs enable our reprogramming (Jose Polo), and multimedia discoveries to proceed to application in the clinic. In this approaches to obtaining patient consent for donation respect, it is timely to reflect on some of our scientific of tissue for producing induced pluripotent stem cells breakthroughs over the past several years. (Alice Pébay and Megan Munsie). Amongst the highlights are Robert Graham’s discovery Dissertations from SCA students successfully of the ability of the adult heart to undergo regeneration, completing their doctoral studies reflected the breadth Lars Nielsen’s development of a cell culture platform of the consortium’s interests, with exciting new findings to produce white blood cells for treatment of cancer in analysis of time lapse imaging of stem cells, (James patients, Melissa Little’s striking demonstration of Cornwell), early stages of blood cell formation (Kathy how to grow a human kidney from pluripotent stem Potts), chemical genomic analysis of early steps in cells in the laboratory, and the report from the team human brain development (Stephanie Bellmaine), and of Elizabeth Ng, Ed Stanley and Andrew Elefanty modelling of stem cell lineage commitment (Jessica describing the generation of blood stem cells from Schwaber). This year SCA scientists authored over 150 human pluripotent