Daubert Vs. Frye: Logical Empiricism and Reliable Science
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Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Contextualizing Systems Biology
Martin Döring Imme Petersen Anne Brüninghaus Regine Kollek Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Contextualizing Systems Biology Martin Döring • Imme Petersen Anne Brüninghaus • Regine Kollek Contextualizing Systems Biology Presuppositions and Implications of a New Approach in Biology Martin Döring Imme Petersen University of Hamburg University of Hamburg Hamburg , Germany Hamburg , Germany Anne Brüninghaus Regine Kollek University of Hamburg University of Hamburg Hamburg , Germany Hamburg , Germany ISBN 978-3-319-17105-0 ISBN 978-3-319-17106-7 (eBook) DOI 10.1007/978-3-319-17106-7 Library of Congress Control Number: 2015944085 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. -
Spelman K. Ecological Pharmacology
C H A P T E R 27 Ecological Pharmacy: Molecular Biology to Systems Theory KEVIN SPELMAN First, the world of life, taken as a whole, forms a single system tional aspect of a system’s components gives us little bound to the surface of the earth; a system whose elements, in whatever indication of the behavior of the corresponding networks order of association they may be considered, are not simply thrown (Buehler, 2003a,b). The properties of a system cannot be together and molded upon one another like grains of sand, but are understood by accounting only for the properties of its organically interdependent like . molecules caught in a capillary components. surface. The medical sciences, and especially pharmacology, —TEILHARD DE CHARDIN, 1943 have fully embraced the reductionist construct, implying that human health can be reduced to the modulation of In the middle of the last century, some years before the specific genes and proteins. The laboratory modeling has, discovery of DNA, Erwin Schrödinger, in his classic 1944 until recently, limited observations to the interaction book What is Life?, inspired a generation of scientists with between one gene or protein with a single chemical. Such his timeless philosophical question: “How can the events simplistic modeling has led to some life-saving drugs, but in space and time which take place within the spatial has also lead to pharmaceutical drugs (even when properly boundary of a living organism be accounted for by physics prescribed) being an embarrassing and unfortunate lead- and chemistry?” (Schrödinger, 1944). To start at the micro- ing cause of death in the United States. -
Examining Pre-Service Science Teachers' Opinions
Available online at www.sciencedirect.com Procedia Social and Behavioral Sciences 15 (2011) 2764–2770 WCES-2011 Examining pre-service science teachers’ opinions about holistic approach in science: Electrical energy example Özlem AltÕnkaynak YaylacÕa , Havva Yamakb, Nusret Kavakc aGazi University Institute of Science, Ankara bGazi University, Gazi Faculty of Education, Department of Science Education, 06500, Ankara cGazi University, Gazi Faculty of Education, Department of Chemistry Education, 06500, Ankara Abstract The aim of this study is to examine pre-service science teachers’ opinions about holistic approach to science. The participants of this case study consisted of 6 elementary pre-service science teachers. While choosing the participants, the electrical energy inventory was administered to 62 pre-service teachers. The data were collected by using a semi-structured individual interview. The findings of the study showed that pre-service science teachers have lack of knowledge and misconceptions about transmission of a nerve impulse, electrical circuit, and electrochemistry. In the lights of findings pre-service science teachers could not interrelate these concepts as holistically. © 2011 Published by Elsevier Ltd. Keywords: Pre-service science teacher, holism in science, electrical energy 1. Introduction Holism is in contrast to a purely analytic tradition (sometimes called reductionism) which aims to gain understanding of systems by dividing them into smaller composing elements and gaining understanding of the system through understanding their elemental properties. Holism in science, or Holistic science, is an approach to research that emphasizes the study of complex systems. The one of central aspects is the way of doing science, sometimes called "whole to parts," which focuses on observation of the specimen within its ecosystem first before breaking down to study any part of the specimen. -
Statistical Significance and Statistical Error in Antitrust Analysis
STATISTICAL SIGNIFICANCE AND STATISTICAL ERROR IN ANTITRUST ANALYSIS PHILLIP JOHNSON EDWARD LEAMER JEFFREY LEITZINGER* Proof of antitrust impact and estimation of damages are central elements in antitrust cases. Generally, more is needed for these purposes than simple ob- servational evidence regarding changes in price levels over time. This is be- cause changes in economic conditions unrelated to the behavior at issue also may play a role in observed outcomes. For example, prices of consumer elec- tronics have been falling for several decades because of technological pro- gress. Against that backdrop, a successful price-fixing conspiracy may not lead to observable price increases but only slow their rate of decline. There- fore, proof of impact and estimation of damages often amounts to sorting out the effects on market outcomes of illegal behavior from the effects of other market supply and demand factors. Regression analysis is a statistical technique widely employed by econo- mists to identify the role played by one factor among those that simultane- ously determine market outcomes. In this way, regression analysis is well suited to proof of impact and estimation of damages in antitrust cases. For that reason, regression models have become commonplace in antitrust litigation.1 In our experience, one aspect of regression results that often attracts spe- cific attention in that environment is the statistical significance of the esti- mates. As is discussed below, some courts, participants in antitrust litigation, and commentators maintain that stringent levels of statistical significance should be a threshold requirement for the results of regression analysis to be used as evidence regarding impact and damages. -
Statistical Proof of Discrimination: Beyond "Damned Lies"
Washington Law Review Volume 68 Number 3 7-1-1993 Statistical Proof of Discrimination: Beyond "Damned Lies" Kingsley R. Browne Follow this and additional works at: https://digitalcommons.law.uw.edu/wlr Part of the Labor and Employment Law Commons Recommended Citation Kingsley R. Browne, Statistical Proof of Discrimination: Beyond "Damned Lies", 68 Wash. L. Rev. 477 (1993). Available at: https://digitalcommons.law.uw.edu/wlr/vol68/iss3/2 This Article is brought to you for free and open access by the Law Reviews and Journals at UW Law Digital Commons. It has been accepted for inclusion in Washington Law Review by an authorized editor of UW Law Digital Commons. For more information, please contact [email protected]. Copyright © 1993 by Washington Law Review Association STATISTICAL PROOF OF DISCRIMINATION: BEYOND "DAMNED LIES" Kingsley R. Browne* Abstract Evidence that an employer's work force contains fewer minorities or women than would be expected if selection were random with respect to race and sex has been taken as powerful-and often sufficient-evidence of systematic intentional discrimina- tion. In relying on this kind of statistical evidence, courts have made two fundamental errors. The first error is assuming that statistical analysis can reveal the probability that observed work-force disparities were produced by chance. This error leads courts to exclude chance as a cause when such a conclusion is unwarranted. The second error is assuming that, except for random deviations, the work force of a nondiscriminating employer would mirror the racial and sexual composition of the relevant labor force. This assumption has led courts inappropriately to shift the burden of proof to employers in pattern-or-practice cases once a statistical disparity is shown. -
Exploratory Versus Confirmative Testing in Clinical Trials
xperim & E en Gaus et al., Clin Exp Pharmacol 2015, 5:4 l ta a l ic P in h DOI: 10.4172/2161-1459.1000182 l a C r m f Journal of o a l c a o n l o r g u y o J ISSN: 2161-1459 Clinical and Experimental Pharmacology Research Article Open Access Interpretation of Statistical Significance - Exploratory Versus Confirmative Testing in Clinical Trials, Epidemiological Studies, Meta-Analyses and Toxicological Screening (Using Ginkgo biloba as an Example) Wilhelm Gaus, Benjamin Mayer and Rainer Muche Institute for Epidemiology and Medical Biometry, University of Ulm, Germany *Corresponding author: Wilhelm Gaus, University of Ulm, Institute for Epidemiology and Medical Biometry, Schwabstrasse 13, 89075 Ulm, Germany, Tel : +49 731 500-26891; Fax +40 731 500-26902; E-mail: [email protected] Received date: June 18 2015; Accepted date: July 23 2015; Published date: July 27 2015 Copyright: © 2015 Gaus W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract The terms “significant” and “p-value” are important for biomedical researchers and readers of biomedical papers including pharmacologists. No other statistical result is misinterpreted as often as p-values. In this paper the issue of exploratory versus confirmative testing is discussed in general. A significant p-value sometimes leads to a precise hypothesis (exploratory testing), sometimes it is interpret as “statistical proof” (confirmative testing). A p-value may only be interpreted as confirmative, if (1) the hypothesis and the level of significance were established a priori and (2) an adjustment for multiple testing was carried out if more than one test was performed. -
Quine's Revolution: Epistemological Holism in Science and Philosophy
Quine’s Revolution: Epistemological Holism in Science and Philosophy David Paul Boaz To be is to be the value of a bound variable. —W. V. Quine “On What There Is”: Quine’s Ontological Relativity. Willard Van Orman Quine (1908– 2000) is considered by many in the philosophy trade to be the most important American philosopher of the 20th century. His Ontological Relativity (indeterminacy of reference, indeterminacy of translation) is the thesis that ontology—”what there is”—is relative to language, that is, to the subjective deep background reality assumptions in our individual and collective “web of belief” as it arises and is instantiated in language. (Epistemology is how we know what there is. There are no objective facts, only linguistic meanings.) In his seminal “Ontological Relativity” (1969) Quine develops his thesis that when a theory postulates its existent entities in a given language—its “object language”—it does so by translating its theory’s propositions (statements) about those entities into a more inclusive “meta-language,” langue (Saussure), or background matrix or web of prior assumptions and beliefs. The ontological status of entities or objects of the object language are relative to and supervene or are dependent upon the intersubjective prior cognitive “coordinate grid” that are the assumptions and beliefs of the meta-language into which they are translated. Unfortunately, through ontology is minimized, Quine’s personal ontological flavor is Physicalism. It’s all just physical, which explains his epistemology, namely empiricism and naturalism. Quine was never able to shake the imperious physicalist doctrine of his early teacher Rudolf Carnap and the Vienna Circle of the Logical Positivists. -
Chapter 5. Language: Private, Public, Solitary, Shared on the Received
Chapter 5. Language: private, public, solitary, shared On the received reading of Ludwig Wittgenstein's Philosophical Investigations1, the book contains an argument purporting to show the impossibility of a private language. There has been a lively debate, however, on how the relevant notion of a private language is to be understood, and what considerations should be taken to rule it out. Some have understood Wittgenstein to mean that a language must be something that several speakers actually share, while others take him to mean that a language must be something that they could, in principle, share. Or, slightly differently put, on one view, speaking a language presupposes the actual existence of a linguistic community upholding certain shared standards of meaning and correctness, while on the other view, it only presupposes that such a community might have existed. These views have come to be known as the ‘community view’ and the ‘solitary speaker’ view, respectively.2 Furthermore, supporters of the community view tend to think that the discussion about privacy holds a central place in Wittgenstein’s later philosophy, whereas those who support the solitary speaker view usually see its bearings as limited to the issue of the privacy of experience. 1 Ludwig Wittgenstein, Philosophical Investigations (Oxford: Basil Blackwell, 1958). References to this work will be indicated with the abbreviation PI followed by paragraph number. 2 Rather than two monolithic positions, what we have here is a spectrum of views ranging between two extremes. To mention but a few examples: the best-known formulations of the community view are to be found in Norman Malcolm, “Following a Rule” in his book Nothing is Hidden (Oxford: Basil Blackwell, 1986), as well as in his essay “Wittgenstein on Language and Rules” in Wittgensteinian Themes: Essays 1978-1989 (ed. -
Wittgenstein, Anxiety, and Performance Behavior
Incapacity Incapacity Wittgenstein, Anxiety, and Performance Behavior Spencer Golub northwestern university press evanston, illinois Northwestern University Press www.nupress.northwestern.edu Copyright © 2014 by Spencer Golub. Published 2014 by Northwestern University Press. All rights reserved. Printed in the United States of America 10 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Golub, Spencer, author. Incapacity : Wittgenstein, anxiety, and performance behavior / Spencer Golub. pages cm Includes bibliographical references and index. ISBN 978-0-8101-2992-4 (cloth : alk. paper) 1. Wittgenstein, Ludwig, 1889–1951. 2. Language and languages—Philosophy. 3. Performance—Philosophy. 4. Literature, Modern—20th century—History and criticism. 5. Literature—Philosophy. I. Title. B3376.W564G655 2014 121.68—dc23 2014011601 Except where otherwise noted, this book is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. In all cases attribution should include the following information: Golub, Spencer. Incapacity: Wittgenstein, Anxiety, and Performance Behavior. Evanston: Northwestern University Press, 2014. For permissions beyond the scope of this license, visit http://www.nupress .northwestern.edu/. An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at www.knowledgeunlatched.org. For my mother We go towards the thing we mean. —Wittgenstein, Philosophical Investigations, §455 . -
Inference Procedures Based on Order Statistics
INFERENCE PROCEDURES BASED ON ORDER STATISTICS DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Jesse C. Frey, M.S. * * * * * The Ohio State University 2005 Dissertation Committee: Approved by Prof. H. N. Nagaraja, Adviser Prof. Steven N. MacEachern Adviser ¨ ¨ Prof. Omer Ozturk¨ Graduate Program in Prof. Douglas A. Wolfe Statistics ABSTRACT In this dissertation, we develop several new inference procedures that are based on order statistics. Each procedure is motivated by a particular statistical problem. The first problem we consider is that of computing the probability that a fully- specified collection of independent random variables has a particular ordering. We derive an equal conditionals condition under which such probabilities can be computed exactly, and we also derive extrapolation algorithms that allow approximation and computation of such probabilities in more general settings. Romberg integration is one idea that is used. The second problem we address is that of producing optimal distribution-free confidence bands for a cumulative distribution function. We treat this problem both in the case of simple random sampling and in the more general case in which the sample consists of independent order statistics from the distribution of interest. The latter case includes ranked-set sampling. We propose a family of optimality criteria motivated by the idea that good confidence bands are narrow, and we develop theory that makes the identification and computation of optimal bands possible. The Brunn-Minkowski Inequality from the theory of convex bodies plays a key role in this work. -
Wittgenstein and Haydn on Understanding Music
Contemporary Aesthetics (Journal Archive) Volume 4 Volume 4 (2006) Article 15 2006 Wittgenstein and Haydn on Understanding Music Yael Kaduri Bezalel Academy of Art and Design, Jerusalem, [email protected] Follow this and additional works at: https://digitalcommons.risd.edu/liberalarts_contempaesthetics Part of the Aesthetics Commons Recommended Citation Kaduri, Yael (2006) "Wittgenstein and Haydn on Understanding Music," Contemporary Aesthetics (Journal Archive): Vol. 4 , Article 15. Available at: https://digitalcommons.risd.edu/liberalarts_contempaesthetics/vol4/iss1/15 This Article is brought to you for free and open access by the Liberal Arts Division at DigitalCommons@RISD. It has been accepted for inclusion in Contemporary Aesthetics (Journal Archive) by an authorized editor of DigitalCommons@RISD. For more information, please contact [email protected]. Wittgenstein and Haydn on Understanding Music Yael Kaduri About CA Abstract Journal Wittgenstein's remarks about music have motivated philosophers to build a comprehensive picture of his philosophy of music, concentrating on the central Contact CA issues of musical meaning. It is often claimed that, according to Wittgenstein, understanding music consist in grasping the internal relationships between Links musical events. Musical practice, however, is naturally saturated with what philosophers often call extra-musical meanings. The present study, by Submissions considering a musical issue in Haydn's instrumental music, attempts to show that musical language games in the Wittgensteinian sense involve explanations Search Journal of music that enhance the listener's ability to understand music by broadening his musical competence. Nevertheless, constituting understanding of music, these explanations might use professional musical terms as well as non-musical terms, comparisons, gestures and so on. -
Ebook-Mumford-Laws-In-Nature.Pdf
Laws in Nature What are the laws of nature? Do they control the actions and movements of the other things that exist in our world? Is there a sense in which such laws are real things? Both scientists and philosophers have been attracted by the view that the world contains laws of nature. It is such laws that dictate the behaviour of particulars, rather than any of those things’ intrinsic or internal forces. In this book Stephen Mumford argues against this popular view. He shows that no adequate account has been produced of what such laws in nature would be, or how they would perform the work that has been required of them. In their place, he argues that there are other necessary connections in nature that can do all the work for which we thought laws were needed. This book offers a holistic and connected account of reality in which the world’s elements do not need to be activated or controlled by laws. It is not possible that these elements behave other than they do. The world is more of a jigsaw than a mosaic: its pieces can form only one picture, and laws are no part of it. Stephen Mumford is Reader in Metaphysics in the Department of Philo- sophy at the University of Nottingham. He is the author of Dispositions (1998) and various papers in metaphysics. He is editor of Russell on Meta- physics (2003) and Powers by the late George Molnar (2003). Routledge studies in twentieth-century philosophy 1 The Story of Analytic Philosophy Plot and heroes Edited by Anat Biletzki and Anat Matar 2 Donald Davidson Truth, meaning and knowledge Edited by Urszula M.