University of Kentucky UKnowledge University of Kentucky Doctoral Dissertations Graduate School 2010 STUDIES TOWARD THE TOTAL SYNTHESIS OF (±)-α-YOHIMBINE BY DOUBLE ANNULATION Raghu Ram Chamala University of Kentucky,
[email protected] Right click to open a feedback form in a new tab to let us know how this document benefits ou.y Recommended Citation Chamala, Raghu Ram, "STUDIES TOWARD THE TOTAL SYNTHESIS OF (±)-α-YOHIMBINE BY DOUBLE ANNULATION" (2010). University of Kentucky Doctoral Dissertations. 78. https://uknowledge.uky.edu/gradschool_diss/78 This Dissertation is brought to you for free and open access by the Graduate School at UKnowledge. It has been accepted for inclusion in University of Kentucky Doctoral Dissertations by an authorized administrator of UKnowledge. For more information, please contact
[email protected]. ABSTRACT OF DISSERTATION Raghu Ram Chamala The Graduate School University of Kentucky 2010 STUDIES TOWARD THE TOTAL SYNTHESIS OF (±)-α-YOHIMBINE BY DOUBLE ANNULATION ABSTRACT OF DISSERTATION A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the College of Arts and Sciences at the University of Kentucky By Raghu Ram Chamala Lexington, KY Director: Dr. R. B. Grossman, Professor of Chemistry Lexington, KY 2010 Copyright © Raghu Ram Chamala 2010 ABSTRACT OF DISSERTATION STUDIES TOWARD THE TOTAL SYNTHESIS OF (±)-α-YOHIMBINE BY DOUBLE ANNULATION The indole alkaloids, a class of natural products, have received much synthetic attention for years due to their diverse structures and interesting biological properties. We are particularly interested in synthesizing some of the yohimbine alkaloids extracted from the bark of a tall evergreen African tree (Corynanthe yohimbe, commonly known as fringe tree).