HARMON on BPM, January 2021 Deepmind Is No Longer Playing
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Artificial Intelligence in Health Care: the Hope, the Hype, the Promise, the Peril
Artificial Intelligence in Health Care: The Hope, the Hype, the Promise, the Peril Michael Matheny, Sonoo Thadaney Israni, Mahnoor Ahmed, and Danielle Whicher, Editors WASHINGTON, DC NAM.EDU PREPUBLICATION COPY - Uncorrected Proofs NATIONAL ACADEMY OF MEDICINE • 500 Fifth Street, NW • WASHINGTON, DC 20001 NOTICE: This publication has undergone peer review according to procedures established by the National Academy of Medicine (NAM). Publication by the NAM worthy of public attention, but does not constitute endorsement of conclusions and recommendationssignifies that it is the by productthe NAM. of The a carefully views presented considered in processthis publication and is a contributionare those of individual contributors and do not represent formal consensus positions of the authors’ organizations; the NAM; or the National Academies of Sciences, Engineering, and Medicine. Library of Congress Cataloging-in-Publication Data to Come Copyright 2019 by the National Academy of Sciences. All rights reserved. Printed in the United States of America. Suggested citation: Matheny, M., S. Thadaney Israni, M. Ahmed, and D. Whicher, Editors. 2019. Artificial Intelligence in Health Care: The Hope, the Hype, the Promise, the Peril. NAM Special Publication. Washington, DC: National Academy of Medicine. PREPUBLICATION COPY - Uncorrected Proofs “Knowing is not enough; we must apply. Willing is not enough; we must do.” --GOETHE PREPUBLICATION COPY - Uncorrected Proofs ABOUT THE NATIONAL ACADEMY OF MEDICINE The National Academy of Medicine is one of three Academies constituting the Nation- al Academies of Sciences, Engineering, and Medicine (the National Academies). The Na- tional Academies provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. -
AI Computer Wraps up 4-1 Victory Against Human Champion Nature Reports from Alphago's Victory in Seoul
The Go Files: AI computer wraps up 4-1 victory against human champion Nature reports from AlphaGo's victory in Seoul. Tanguy Chouard 15 March 2016 SEOUL, SOUTH KOREA Google DeepMind Lee Sedol, who has lost 4-1 to AlphaGo. Tanguy Chouard, an editor with Nature, saw Google-DeepMind’s AI system AlphaGo defeat a human professional for the first time last year at the ancient board game Go. This week, he is watching top professional Lee Sedol take on AlphaGo, in Seoul, for a $1 million prize. It’s all over at the Four Seasons Hotel in Seoul, where this morning AlphaGo wrapped up a 4-1 victory over Lee Sedol — incidentally, earning itself and its creators an honorary '9-dan professional' degree from the Korean Baduk Association. After winning the first three games, Google-DeepMind's computer looked impregnable. But the last two games may have revealed some weaknesses in its makeup. Game four totally changed the Go world’s view on AlphaGo’s dominance because it made it clear that the computer can 'bug' — or at least play very poor moves when on the losing side. It was obvious that Lee felt under much less pressure than in game three. And he adopted a different style, one based on taking large amounts of territory early on rather than immediately going for ‘street fighting’ such as making threats to capture stones. This style – called ‘amashi’ – seems to have paid off, because on move 78, Lee produced a play that somehow slipped under AlphaGo’s radar. David Silver, a scientist at DeepMind who's been leading the development of AlphaGo, said the program estimated its probability as 1 in 10,000. -
Prominence of Expert System and Case Study- DENDRAL Namita Mirjankar, Shruti Ghatnatti Karnataka, India [email protected],[email protected]
International Journal of Advanced Networking & Applications (IJANA) ISSN: 0975-0282 Prominence of Expert System and Case Study- DENDRAL Namita Mirjankar, Shruti Ghatnatti Karnataka, India [email protected],[email protected] Abstract—Among many applications of Artificial Intelligence, Expert System is the one that exploits human knowledge to solve problems which ordinarily would require human insight. Expert systems are designed to carry the insight and knowledge found in the experts in a particular field and take decisions based on the accumulated knowledge of the knowledge base along with an arrangement of standards and principles of inference engine, and at the same time, justify those decisions with the help of explanation facility. Inference engine is continuously updated as new conclusions are drawn from each new certainty in the knowledge base which triggers extra guidelines, heuristics and rules in the inference engine. This paper explains the basic architecture of Expert System , its first ever success DENDRAL which became a stepping stone in the Artificial Intelligence field, as well as the difficulties faced by the Expert Systems Keywords—Artificial Intelligence; Expert System architecture; knowledge base; inference engine; DENDRAL I INTRODUCTION the main components that remain same are: User Interface, Knowledge Base and Inference Engine. For more than two thousand years, rationalists all over the world have been striving to comprehend and resolve two unavoidable issues of the universe: how does a human mind work, and can non-people have minds? In any case, these inquiries are still unanswered. As humans, we all are blessed with the ability to learn and comprehend, to think about different issues and to decide; but can we design machines to do all these things? Some philosophers are open to the idea that machines will perform all the tasks a human can do. -
In-Datacenter Performance Analysis of a Tensor Processing Unit
In-Datacenter Performance Analysis of a Tensor Processing Unit Presented by Josh Fried Background: Machine Learning Neural Networks: ● Multi Layer Perceptrons ● Recurrent Neural Networks (mostly LSTMs) ● Convolutional Neural Networks Synapse - each edge, has a weight Neuron - each node, sums weights and uses non-linear activation function over sum Propagating inputs through a layer of the NN is a matrix multiplication followed by an activation Background: Machine Learning Two phases: ● Training (offline) ○ relaxed deadlines ○ large batches to amortize costs of loading weights from DRAM ○ well suited to GPUs ○ Usually uses floating points ● Inference (online) ○ strict deadlines: 7-10ms at Google for some workloads ■ limited possibility for batching because of deadlines ○ Facebook uses CPUs for inference (last class) ○ Can use lower precision integers (faster/smaller/more efficient) ML Workloads @ Google 90% of ML workload time at Google spent on MLPs and LSTMs, despite broader focus on CNNs RankBrain (search) Inception (image classification), Google Translate AlphaGo (and others) Background: Hardware Trends End of Moore’s Law & Dennard Scaling ● Moore - transistor density is doubling every two years ● Dennard - power stays proportional to chip area as transistors shrink Machine Learning causing a huge growth in demand for compute ● 2006: Excess CPU capacity in datacenters is enough ● 2013: Projected 3 minutes per-day per-user of speech recognition ○ will require doubling datacenter compute capacity! Google’s Answer: Custom ASIC Goal: Build a chip that improves cost-performance for NN inference What are the main costs? Capital Costs Operational Costs (power bill!) TPU (V1) Design Goals Short design-deployment cycle: ~15 months! Plugs in to PCIe slot on existing servers Accelerates matrix multiplication operations Uses 8-bit integer operations instead of floating point How does the TPU work? CISC instructions, issued by host. -
AI for Health Examples from Industry, Government, and Academia Table of Contents
guidehouse.com AI for Health Examples from industry, government, and academia Table of Contents Abstract 3 Introduction to artificial intelligence 4 Introduction to health data 7 Molecules: AI for understanding biology and developing therapies 10 Fundamental research 10 Drug development 11 Patients: AI for predicting disease and improving care 13 Diagnostics and outcome risks 13 Personalized medicine 14 Groups: AI for optimizing clinical trials and safeguarding public health 15 Clinical trials 15 Public health 17 Conclusion and outlook 18 2 Guidehouse Abstract This paper is directed toward a health-informed reader who is curious about the developments and potential of artificial intelligence (AI) in the health space, but could equally be read by AI practitioners curious about how their knowledge and methods are being used to advance human health. We present a brief, equation-free introduction to AI and its major subfields in order to provide a framework for understanding the technical context of the examples that follow. We discuss the various data sources available for questions of health and life sciences, as well as the unique challenges inherent to these fields. We then consider recent (past five years) applications of AI that have already had tangible, measurable impact to the advancement of biomedical knowledge and the development of new and improved treatments. These examples are organized by scale, ranging from the molecule (fundamental research and drug development) to the patient (diagnostics, risk-scoring, and personalized medicine) to the group (clinical trials and public health). Finally, we conclude with a brief summary and our outlook for the future of AI for health. -
Pre-Training of Deep Bidirectional Protein Sequence Representations with Structural Information
Date of publication xxxx 00, 0000, date of current version xxxx 00, 0000. Digital Object Identifier 10.1109/ACCESS.2017.DOI Pre-training of Deep Bidirectional Protein Sequence Representations with Structural Information SEONWOO MIN1,2, SEUNGHYUN PARK3, SIWON KIM1, HYUN-SOO CHOI4, BYUNGHAN LEE5 (Member, IEEE), and SUNGROH YOON1,6 (Senior Member, IEEE) 1Department of Electrical and Computer engineering, Seoul National University, Seoul 08826, South Korea 2LG AI Research, Seoul 07796, South Korea 3Clova AI Research, NAVER Corp., Seongnam 13561, South Korea 4Department of Computer Science and Engineering, Kangwon National University, Chuncheon 24341, South Korea 5Department of Electronic and IT Media Engineering, Seoul National University of Science and Technology, Seoul 01811, South Korea 6Interdisciplinary Program in Artificial Intelligence, ASRI, INMC, and Institute of Engineering Research, Seoul National University, Seoul 08826, South Korea Corresponding author: Byunghan Lee ([email protected]) or Sungroh Yoon ([email protected]) This research was supported by the National Research Foundation (NRF) of Korea grants funded by the Ministry of Science and ICT (2018R1A2B3001628 (S.Y.), 2014M3C9A3063541 (S.Y.), 2019R1G1A1003253 (B.L.)), the Ministry of Agriculture, Food and Rural Affairs (918013-4 (S.Y.)), and the Brain Korea 21 Plus Project in 2021 (S.Y.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ABSTRACT Bridging the exponentially growing gap between the numbers of unlabeled and labeled protein sequences, several studies adopted semi-supervised learning for protein sequence modeling. In these studies, models were pre-trained with a substantial amount of unlabeled data, and the representations were transferred to various downstream tasks. -
Biological Structure and Function Emerge from Scaling Unsupervised Learning to 250 Million Protein Sequences
bioRxiv preprint doi: https://doi.org/10.1101/622803; this version posted May 29, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. BIOLOGICAL STRUCTURE AND FUNCTION EMERGE FROM SCALING UNSUPERVISED LEARNING TO 250 MILLION PROTEIN SEQUENCES Alexander Rives ∗y z Siddharth Goyal ∗x Joshua Meier ∗x Demi Guo ∗x Myle Ott x C. Lawrence Zitnick x Jerry Ma y x Rob Fergus y z x ABSTRACT In the field of artificial intelligence, a combination of scale in data and model capacity enabled by unsupervised learning has led to major advances in representation learning and statistical generation. In biology, the anticipated growth of sequencing promises unprecedented data on natural sequence diversity. Learning the natural distribution of evolutionary protein sequence variation is a logical step toward predictive and generative modeling for biology. To this end we use unsupervised learning to train a deep contextual language model on 86 billion amino acids across 250 million sequences spanning evolutionary diversity. The resulting model maps raw sequences to representations of biological properties without labels or prior domain knowledge. The learned representation space organizes sequences at multiple levels of biological granularity from the biochemical to proteomic levels. Unsupervised learning recovers information about protein structure: secondary structure and residue-residue contacts can be identified by linear projections from the learned representations. Training language models on full sequence diversity rather than individual protein families increases recoverable information about secondary structure. -
Understanding & Generalizing Alphago Zero
Under review as a conference paper at ICLR 2019 UNDERSTANDING &GENERALIZING ALPHAGO ZERO Anonymous authors Paper under double-blind review ABSTRACT AlphaGo Zero (AGZ) (Silver et al., 2017b) introduced a new tabula rasa rein- forcement learning algorithm that has achieved superhuman performance in the games of Go, Chess, and Shogi with no prior knowledge other than the rules of the game. This success naturally begs the question whether it is possible to develop similar high-performance reinforcement learning algorithms for generic sequential decision-making problems (beyond two-player games), using only the constraints of the environment as the “rules.” To address this challenge, we start by taking steps towards developing a formal understanding of AGZ. AGZ includes two key innovations: (1) it learns a policy (represented as a neural network) using super- vised learning with cross-entropy loss from samples generated via Monte-Carlo Tree Search (MCTS); (2) it uses self-play to learn without training data. We argue that the self-play in AGZ corresponds to learning a Nash equilibrium for the two-player game; and the supervised learning with MCTS is attempting to learn the policy corresponding to the Nash equilibrium, by establishing a novel bound on the difference between the expected return achieved by two policies in terms of the expected KL divergence (cross-entropy) of their induced distributions. To extend AGZ to generic sequential decision-making problems, we introduce a robust MDP framework, in which the agent and nature effectively play a zero-sum game: the agent aims to take actions to maximize reward while nature seeks state transitions, subject to the constraints of that environment, that minimize the agent’s reward. -
AI for Broadcsaters, Future Has Already Begun…
AI for Broadcsaters, future has already begun… By Dr. Veysel Binbay, Specialist Engineer @ ABU Technology & Innovation Department 0 Dr. Veysel Binbay I have been working as Specialist Engineer at ABU Technology and Innovation Department for one year, before that I had worked at TRT (Turkish Radio and Television Corporation) for more than 20 years as a broadcast engineer, and also as an IT Director. I have wide experience on Radio and TV broadcasting technologies, including IT systems also. My experience includes to design, to setup, and to operate analogue/hybrid/digital radio and TV broadcast systems. I have also experienced on IT Networks. 1/25 What is Artificial Intelligence ? • Programs that behave externally like humans? • Programs that operate internally as humans do? • Computational systems that behave intelligently? 2 Some Definitions Trials for AI: The exciting new effort to make computers think … machines with minds, in the full literal sense. Haugeland, 1985 3 Some Definitions Trials for AI: The study of mental faculties through the use of computational models. Charniak and McDermott, 1985 A field of study that seeks to explain and emulate intelligent behavior in terms of computational processes. Schalkoff, 1990 4 Some Definitions Trials for AI: The study of how to make computers do things at which, at the moment, people are better. Rich & Knight, 1991 5 It’s obviously hard to define… (since we don’t have a commonly agreed definition of intelligence itself yet)… Lets try to focus to benefits, and solve definition problem later… 6 Brief history of AI 7 Brief history of AI . The history of AI begins with the following article: . -
Efficiently Mastering the Game of Nogo with Deep Reinforcement
electronics Article Efficiently Mastering the Game of NoGo with Deep Reinforcement Learning Supported by Domain Knowledge Yifan Gao 1,*,† and Lezhou Wu 2,† 1 College of Medicine and Biological Information Engineering, Northeastern University, Liaoning 110819, China 2 College of Information Science and Engineering, Northeastern University, Liaoning 110819, China; [email protected] * Correspondence: [email protected] † These authors contributed equally to this work. Abstract: Computer games have been regarded as an important field of artificial intelligence (AI) for a long time. The AlphaZero structure has been successful in the game of Go, beating the top professional human players and becoming the baseline method in computer games. However, the AlphaZero training process requires tremendous computing resources, imposing additional difficulties for the AlphaZero-based AI. In this paper, we propose NoGoZero+ to improve the AlphaZero process and apply it to a game similar to Go, NoGo. NoGoZero+ employs several innovative features to improve training speed and performance, and most improvement strategies can be transferred to other nonspecific areas. This paper compares it with the original AlphaZero process, and results show that NoGoZero+ increases the training speed to about six times that of the original AlphaZero process. Moreover, in the experiment, our agent beat the original AlphaZero agent with a score of 81:19 after only being trained by 20,000 self-play games’ data (small in quantity compared with Citation: Gao, Y.; Wu, L. Efficiently 120,000 self-play games’ data consumed by the original AlphaZero). The NoGo game program based Mastering the Game of NoGo with on NoGoZero+ was the runner-up in the 2020 China Computer Game Championship (CCGC) with Deep Reinforcement Learning limited resources, defeating many AlphaZero-based programs. -
AI Chips: What They Are and Why They Matter
APRIL 2020 AI Chips: What They Are and Why They Matter An AI Chips Reference AUTHORS Saif M. Khan Alexander Mann Table of Contents Introduction and Summary 3 The Laws of Chip Innovation 7 Transistor Shrinkage: Moore’s Law 7 Efficiency and Speed Improvements 8 Increasing Transistor Density Unlocks Improved Designs for Efficiency and Speed 9 Transistor Design is Reaching Fundamental Size Limits 10 The Slowing of Moore’s Law and the Decline of General-Purpose Chips 10 The Economies of Scale of General-Purpose Chips 10 Costs are Increasing Faster than the Semiconductor Market 11 The Semiconductor Industry’s Growth Rate is Unlikely to Increase 14 Chip Improvements as Moore’s Law Slows 15 Transistor Improvements Continue, but are Slowing 16 Improved Transistor Density Enables Specialization 18 The AI Chip Zoo 19 AI Chip Types 20 AI Chip Benchmarks 22 The Value of State-of-the-Art AI Chips 23 The Efficiency of State-of-the-Art AI Chips Translates into Cost-Effectiveness 23 Compute-Intensive AI Algorithms are Bottlenecked by Chip Costs and Speed 26 U.S. and Chinese AI Chips and Implications for National Competitiveness 27 Appendix A: Basics of Semiconductors and Chips 31 Appendix B: How AI Chips Work 33 Parallel Computing 33 Low-Precision Computing 34 Memory Optimization 35 Domain-Specific Languages 36 Appendix C: AI Chip Benchmarking Studies 37 Appendix D: Chip Economics Model 39 Chip Transistor Density, Design Costs, and Energy Costs 40 Foundry, Assembly, Test and Packaging Costs 41 Acknowledgments 44 Center for Security and Emerging Technology | 2 Introduction and Summary Artificial intelligence will play an important role in national and international security in the years to come. -
Machine Learning for Speech Recognition by Alice Coucke, Head of Machine Learning Research
Machine Learning for Speech Recognition by Alice Coucke, Head of Machine Learning Research @alicecoucke [email protected] Outline: 1. Recent advances in machine learning 2. From physics to machine learning IA en général Speech & NLP Startup 3. Working at Snips (now Sonos) Snips A lot of applications in the real world, quite a difference from theoretical work Un des rares domaines scientifiques où la théorie et la pratique sont très emmêlées Recent Advances in Applied Machine Learning A lot of applications in the real world, quite a difference from theoretical work Reinforcement learning Learning goal-oriented behavior within simulated environments Go Starcraft II Dota 2 AlphaGo (Deepmind, 2016) AlphaStar (Deepmind) OpenAI Five (OpenAI) Play-driven learning for robots Sim-to-real dexterity learning (Google Brain) Project BLUE (UC Berkeley) Machine Learning for Life Sciences Deep learning applied to biology and medicine Protein folding & structure Cardiac arrhythmia prediction Eye disease diagnosis prediction (NHS, UCL, Deepmind) from ECGs AlphaFold (Deepmind) (Stanford) Reconstruct speech from neural activity Limb control restoration (UCSF) (Batelle, Ohio State Univ) Computer vision High-level understanding of digital images or videos GANs for image generation (Heriot Watt Univ, DeepMind) « Common sense » understanding of actions in videos (TwentyBn, DeepMind, MIT, IBM…) GANs for artificial video dubbing GAN for full body synthesis (Synthesia) (DataGrid) From physics to machine learning and back A surge of interest from the physics community