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Primary Tracheal Squamous Cell Carcinoma - Presenting with Circumferential Invasion and Treated with Photodynamic Therapy

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Primary Tracheal Squamous Cell Carcinoma - Presenting with Circumferential Invasion and Treated with Photodynamic Therapy 218 Primary Tracheal Squamous Cell Carcinoma - Presenting with Circumferential Invasion and Treated with Photodynamic Therapy Lih-Yu Chang*, Sheng-Kai Liang**, Chia-Lin Hsu*, Jang-Ming Lee***, Chong-Jen Yu* Primary neoplasms of the trachea are extremely rare. The diagnosis usually depends on computed tomography (CT) scan. We report a 50-year-old woman who suffered from chronic productive cough for 1 year. Roentgenograms and chest CT showed no abnormal finding. Bronchoscopy showed diffuse circumferential papilloma-like lesions at the trachea. Endobronchial ultrasound showed submucosal invasion of the trachea. The pathology of the endotracheal biopsy showed squamous cell carcinoma. She received photodynamic therapy as first-line treatment with a good response and tumor regression. (Thorac Med 2014; 29: 218-223) Key words: squamous cell carcinoma, tracheal tumor, bronchoscopy, endobronchial ultrasound, photodynamic therapy Introduction agnosis of tracheal tumor and evaluation of the relationship between the surrounding tissue and Primary tracheal tumors are rare, and are organs [1]. Pulmonary function test may show usually malignant in adults (80-90%) and be- fixed upper airway obstruction [1]. Bronchos- nign in children (60-70%) [1-2]. Clinical pre- copy is used for tissue sampling and assessment sentations include dyspnea (58%), cough (54%), of the location and extent of the disease [1]. hemoptysis (45%), wheezing (36%) and stri- In previous reports, tracheal tumor almost dor (24%) [3]. Diagnosis is often delayed for always presented with a protruding mass and months due to initial misdiagnosis as asthma, could be easy diagnosed by chest CT. We pres- chronic obstructive airway disease, or chronic ent a case of primary tracheal squamous cell bronchitis. carcinoma with circumferential invasion, which The conventional chest radiograph is usu- is difficult to diagnose with chest CT. The pa- ally not diagnostic. Computed tomography (CT) tient was treated with photodynamic therapy scan is the most important imaging tool for di- (PDT) after diagnosis. *Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan **Department of Internal Medicine, National Taiwan University Hospital, Hsinchu branch, Hsinchu, Taiwan ***Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Address reprint requests to: Dr. Chia-Lin Hsu, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, No. 7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, Taiwan (R.O.C.) Thorac Med 2014. Vol. 29 No. 4 Primary Tracheal SCC with Circumferential Invasion and Treated with PDT 219 Case Report invasion, and showed the tumor submucosal in- vasion. Malignant neoplasm was suspected and A 50-year-old woman with a history of hy- several endobronchial biopsies were taken from perthyroidism under medical control suffered the papilloma-like lesion. Pathology showed from chronic productive cough for 1 year. Her squamous cell carcinoma and dysplastic squa- symptom exacerbated when in contact with mous epithelium. The squamous cell carcinoma cold air or cold water. No fever, chills, dyspnea, showed diffuse and strong positive immuno- or body weight loss was noted during this pe- reactivity to p16. Since the human papilloma riod. She first visited a hospital in Hsinchu City, virus (HPV) can degrade retinoblastoma protein where the chest radiography (Figure 1) and and lead to aberrant overexpression of p16, the pulmonary function test each showed no abnor- pathology presentation was compatible with mal findings. Chest CT revealed no lung paren- HPV-related neoplasm [4]. No evidence of gas- chymal lesion or endotracheal/endobronchial trointestinal tract malignancy or nasopharyngeal lesion. She was transferred to our hospital for cancer was seen. The final diagnosis was prima- further work-up. Bronchoscopy was performed ry tracheal squamous cell carcinoma. Staging and showed diffuse tracheal mucosal swell- work-up for primary tracheal cancer was then ing with circumferential papilloma-like lesions completed. The final stage was T4N0M0, stage (Figure 2). The tracheal tumor was located from IIIA, according to the 7th edition of the TNM 2 cm below the vocal cord to 1 cm above the ca- system for lung and pleural tumors, but the rina, with a total length of about 6.5 cm. Endo- stage was changed to T2N0M0, stage II, using bronchial ultrasound (EBUS) with radial probe the staging system proposed by Bhattacharyya was performed to evaluate the depth of tracheal [5]. Fig. 2. Bronchoscopy showed diffuse papilloma-like lesions with Fig. 1. No definite airway or parenchymal lesion was noted in the circumferential involvement of the trachea (before photodynamic chest X-ray. therapy) 胸腔醫學：民國 103 年 29 卷 4 期 220 Lih-Yu Chang, Sheng-Kai Liang, et al. Discussion Primary tracheal neoplasm is a rare type of malignancy (0.2% of all respiratory tract malig- nancies; 0.04% of all malignancies) [6]. Squa- mous cell carcinoma and adenoid cystic carci- noma are the most common types and comprise about two-thirds of all adult primary tracheal tumors. Other pathologic types including ad- enocarcinoma, large-cell undifferentiated carci- noma, neuroendocrine tumors, and soft-tissue- type sarcoma [1-2]. Chest radiography usually shows no abnormality and the diagnosis is usu- ally dependent on chest CT scan. However, the Fig. 3. Tracheal tumor regression was noted with bronchoscopy after photodynamic therapy CT scan could not demonstrate the endotracheal lesion in our patient due to circumferential tu- mor invasion without a mass protruding into the tracheal lumen. After discussion with the patient and her The diagnosis of our patient was dependent family, she underwent PDT (energy: 200J, 2 on bronchoscopy, for the following reasons. times, with cytotoxic photosensitizer porfimer First, the tracheal cancer could be seen by bron- sodium (PHOTOFRIN®) 2 mg/kg body weight). choscopy due to the character of the lesion Tumor necrosis with debris-induced airway ob- morphology alone. Second, endobronchial bi- struction occurred repeatedly after PDT (Figure opsy disclosed the nature of the tracheal cancer. 3). At least 3 episodes of acute airway obstruc- Third, the EBUS result showed a lesion with tion occurred within 3 days after PDT. The air- submucosal invasion. The trachea and bronchus way obstruction was relieved by bronchoscopic laminar histologic structure could be identified intervention with removal of the tumor debris. by EBUS, as well [7]. With the EBUS result, After rigid bronchoscopy with tracheal debride- we could determine whether the tracheal lesion ment, the patient was able to wean off the venti- was within the tracheal wall or had invaded lator and extubated successfully. The follow-up other neighborhood structures. endotracheal biopsies 1, 3, and 5 months after The American Joint Committee for Cancer PDT showed no evidence of residual malignant (AJCC) and Union for International Cancer cells. However, she suffered from tracheal ste- Control (UICC) have not established a staging- nosis with the clinical presentation of progres- ing system for primary tracheal cancer. Only sive dyspnea about 45 days after PDT. Balloon 2 staging systems were proposed in 2004 and dilatations were performed several times, but 2006 [1,5]. Due to the rarity of cases, the value tracheal re-stenosis occurred repeatedly and and outcome of the predictive effect of the 2 endotracheal stent implantation had to be per- staging systems requires further investigation. formed about 3 months after PDT. The current recommendation for treatment Thorac Med 2014. Vol. 29 No. 4 Primary Tracheal SCC with Circumferential Invasion and Treated with PDT 221 of tracheal malignancy is surgery [6]. The al- airway malignancies reported the major adverse ternative choices of treatment include radio- effect was skin photosensitivity; other com- therapy, systemic chemotherapy treatment and plications included mild hemoptysis, cough, endotracheal treatment [8]. Of the alternative chest discomfort, tracheal-esophageal fistula, treatment modalities, endotracheal treatment and airway obstruction by tumor debris [18]. could relieve the airway obstruction caused by The overall morbidity rates were between 6-8% the tumor mass sooner. The endotracheal treat- [16]. Post-PDT-related airway obstruction is a ment techniques include mechanical core-out, major complication, especially in patients with electrocoagulation, neodymium-doped yttrium poor pulmonary function. Toilet bronchoscopy aluminum garnet (Nd:YAG) laser, carbon diox- (usually rigid bronchoscopy) performed 1 to 3 ide laser or argon beam coagulation, and cryo- days after PDT to prevent airway obstruction is therapy or PDT. recommended [17]. Tracheal stenosis has been PDT, which was developed in the 1970s, reported, but no incidence rate or peak timing can target cancer selectively by exposing the of the occurrence of stenosis has been reported. target site to light after administration of a In our case, a good treatment response was photosensitizer [9-10]. In general, the indica- observed after PDT. However, the patient also tions for PDT include palliative treatment of suffered from acute airway obstruction and sub- tracheobronchial tree advanced obstructing can- acute tracheal stenosis. cers, and curative treatment of asymptomatic In conclusion, primary tracheal cancer is early lung cancer [11-14]. Due to the delayed rare and the diagnosis is usually delayed. PDT effect
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