(12) Patent Application Publication (10) Pub. No.: US 2016/0136386 A1 Vissman Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2016/0136386 A1 Vissman Et Al US 2016O136386A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0136386 A1 Vissman et al. (43) Pub. Date: May 19, 2016 (54) BOCERAMC COMPOSITIONS AND filed on Oct. 16, 2014, provisional application No. BOMODULATORY USES THEREOF 62/062,686, filed on Oct. 10, 2014, provisional appli cation No. 62/018,085, filed on Jun. 27, 2014, provi (71) Applicant: Multiple Energy Technologies LLC, sional application No. 61/988,837, filed on May 5, Washington, PA (US) 2014. (72) Inventors: Shannon Vissman, Upper St. Clair, PA Publication Classification (US); Francisco Jose Cidral-Filho, Washington, PA (US); Francisco de (51) Int. Cl. Paula Moreira, Florianopolis (BR): A6M2I/02 (2006.01) Steven Midttun, Boca Raton, FL (US) A6IN5/06 (2006.01) (52) U.S. Cl. (21) Appl. No.: 14/965,741 CPC ............. A61M 21/02 (2013.01); A61N 5/0625 (2013.01); A61M 2021/0016 (2013.01) Filed: Dec. 10, 2015 (22) (57) ABSTRACT Related U.S. Application Data The subject matter described herein is directed to articles, compositions, systems, and methods of using and preparing (63) Continuation of application No. 14/702.467, filed on bioceramic compositions and to the bioceramic composi May 1, 2015. tions. A bioceramic composition of the disclosure radiates (60) Provisional application No. 62/115,567, filed on Feb. infrared energy or rays and can be used in the treatment of 12, 2015, provisional application No. 62/064,939, various conditions. Patent Application Publication May 19, 2016 Sheet 1 of 50 US 2016/013638.6 A1 FIGURE Patent Application Publication May 19, 2016 Sheet 2 of 50 US 2016/013638.6 A1 FIGURE 2 Patent Application Publication May 19, 2016 Sheet 4 of 50 US 2016/013638.6 A1 forced vitat capacity (FWC 8883: ... xxx88 x: 8. B 8 : s s :::::::::::: *:::: *:::::: :::::: xit 3xxxx Forced Expired Volume in Second FEW :::::::::::: *8:8 x 3:8:: 88k. xxx::::::::::::::::::::::88x xxxx e. 8. m w wkw M. io-ex : xxxix-xxxx FIGURE 4 Patent Application Publication May 19, 2016 Sheet 5 of 50 US 2016/013638.6 A1 Peak Expiratory Fow (PEF) *:::::::::::: *{x:8-3:83. x8:k {xx8388.88 - 8:38.88: ::::::::::: : : ::::::: " six-gxer xiii-xxxx FIGURE 5 Patent Application Publication May 19, 2016 Sheet 6 of 50 US 2016/013638.6 A1 Muscle Endurance s9. FIGURE 6 Patent Application Publication May 19, 2016 Sheet 7 of 50 US 2016/013638.6 A1 A £8rioresgirst8ty fittess B {articispiratory itess After Wärt-tig After six-gs 83- * 8.3% - 4:3; 88.8. :: * : * : 3.3% 3: 38 328i g 38 g 38; & 8 8.3 : & y :& &*s 8 x x: & 3. sk 'S x8 FIGURE 7 Patent Application Publication May 19, 2016 Sheet 8 of 50 US 2016/013638.6 A1 ay after: ixir treatient ay 2 x after 8 xk text:8t : 88:8. is it as as a sis are score8::::::::::::: ay 3 x after 72 hour treatment t *:: xixe: -- 8 x 3ist *::: * * six xxxx x. :: * * *::::k Exxx xx isx. th at it is sh; sh 8:::::::::::::::::::::: FIGURE 8 Patent Application Publication May 19, 2016 Sheet 9 of 50 US 2016/013638.6 A1 FGURE 9 Patent Application Publication May 19, 2016 Sheet 10 of 50 US 2016/013638.6 A1 FIGURE 10 Patent Application Publication May 19, 2016 Sheet 11 of 50 US 2016/013638.6 A1 FIGURE 11 Patent Application Publication May 19, 2016 Sheet 12 of 50 US 2016/013638.6 A1 AN VE assass& FIGURE 12 Patent Application Publication May 19, 2016 Sheet 13 of 50 US 2016/013638.6 A1 iii. Wii FIGURE 3 Patent Application Publication May 19, 2016 Sheet 14 of 50 US 2016/013638.6 A1 it if 83. FIGURE 14 Patent Application Publication May 19, 2016 Sheet 15 of 50 US 2016/013638.6 A1 CAY SEE VE FIGURE 5 Patent Application Publication May 19, 2016 Sheet 16 of 50 US 2016/013638.6 A1 Rix fi, + xi saaaaaaaayaaaaaaaaaa. FIGURE 16 Patent Application Publication May 19, 2016 Sheet 17 of 50 US 2016/013638.6 A1 Plain iaistic act collapsisitigativ:cetatic : ; r a 38 s a 370 s s: s: - 8xic 3.5x to 1,8x to sixto Temperature (K FIGURE 7 Patent Application Publication May 19, 2016 Sheet 18 of 50 US 2016/013638.6 A1 Bixe:::::ic ::: 3:38: 8:36 e:33:8: FIGURE 18 Patent Application Publication May 19, 2016 Sheet 19 of 50 US 2016/013638.6 A1 Bioceramic fabric (50% Bic{Ceramics $3. $3. $38 & 388 388 3. 38: 9,0xt 8,8xt' oxic' fix Temperature (K FIGURE 19 Patent Application Publication May 19, 2016 Sheet 20 of 50 US 2016/013638.6 A1 ; : 3. Orix: ::::it: : 3:38, ::::::::::: 8: 838, :::::::::::::::: : :: 3::::::::::::: PANEA : PANEL B FIGURE 20 Patent Application Publication May 19, 2016 Sheet 21 of 50 US 2016/013638.6 A1 Eta Feigii Weight without fixts . is + .33% +: 88, FIGURE 2 Patent Application Publication May 19, 2016 Sheet 22 of 50 US 2016/013638.6 A1 Water ejectical condunductivity 8xx-xx-xx-xx-x-xx-xx-xx-xx-xx-xx-x-xx--------------------------------------------------------------------------------------------------------T3 is 3 is is 2 Ewaitiation days FIGURE 22 Patent Application Publication May 19, 2016 Sheet 23 of 50 US 2016/013638.6 A1 & PANEL A PANEL B PANEL C PANELD FIGURE 23 Patent Application Publication May 19, 2016 Sheet 24 of 50 US 2016/013638.6 A1 Won Frey - Tire Course 8 . B 05 2 3 4 Tire after treatneth FIGURE 24 Patent Application Publication May 19, 2016 Sheet 25 of 50 US 2016/013638.6 A1 s'' 8: Patent Application Publication May 19, 2016 Sheet 26 of 50 US 2016/013638.6 A1 Patent Application Publication May 19, 2016 Sheet 28 of 50 US 2016/013638.6 A1 §§§§§?¿ §§§§( §§§§§ ¿? xx it: Patent Application Publication May 19, 2016 Sheet 29 of 50 US 2016/013638.6 A1 ??æðs*********************** §§ ?????????????????? : six Patent Application Publication May 19, 2016 Sheet 30 of 50 US 2016/013638.6 A1 wis: 8338g: S:::::: *::it: i.88: H H-H H- H ::::::::::: $3:8:8: *:::::::::: 3xxxx: 8:88:38 88: 8x88:8 8888:38 &: $888ks: FIGURE 28 Patent Application Publication May 19, 2016 Sheet 31 of 50 US 2016/013638.6 A1 |-------------+ ------ Patent Application Publication May 19, 2016 Sheet 32 of 50 US 2016/013638.6 A1 Screening of participants : x 38 8 participant ineligibies Randomized articipants ; : {x} to group wit.txt { Experiteria group - with crisk x 8 ; : 8 8 ::::::::8 8::::::::: 88icipatts w88 xxpiated six-: *3:38ts w8 xxi.;i&ix: follow-up -...- t ; : 8 FIGURE 30 Patent Application Publication May 19, 2016 Sheet 33 of 50 US 2016/013638.6 A1 ... cartres &roup N Experiterata group Open eyes --- - Closed eyes. : FIG RE 3 Patent Application Publication May 19, 2016 Sheet 34 of 50 US 2016/013638.6 A1 Fixxiiity gig Forces -- 8:33& : 8888. : 83 3.w s H - H-H X - H H 33:8: 388x8: 3:g: 8:ggw8: 83&ife is: 888& D. 8888:3& 8&r 8: 888 FGURE 32 Patent Application Publication May 19, 2016 Sheet 35 of 50 US 2016/013638.6 A1 §§§§§§§§§ ****--> 83.88: 88& Patent Application Publication May 19, 2016 Sheet 36 of 50 US 2016/013638.6 A1 §§§§? Patent Application Publication May 19, 2016 Sheet 37 of 50 US 2016/013638.6 A1 §§ §§§§?§§§ & m - & §§§§?[] Patent Application Publication May 19, 2016 Sheet 38 of 50 US 2016/013638.6 A1 Patent Application Publication May 19, 2016 Sheet 39 of 50 US 2016/013638.6 A1 Patent Application Publication May 19, 2016 Sheet 40 of 50 US 2016/013638.6 A1 4.6OO 2 W FIGURE 38 Patent Application Publication May 19, 2016 Sheet 41 of 50 US 2016/013638.6 A1 s &83888: 838: 8883 8. is: 2. A. 3: e & & : 8:888: 888: 88. & 8. es -3 e s grgrgrg & 83 & 8 x: 8:88: 8888.88. Patent Application Publication May 19, 2016 Sheet 42 of 50 US 2016/013638.6 A1 A B 838 &88: s 300 200 8 s 3 100 e : re s st 38: s s s 3. s : 3.r s . Pre es st FIGURE 4) Patent Application Publication May 19, 2016 Sheet 43 of 50 US 2016/013638.6 A1 83 2 3 s est re st C O 2. : 8 f s FIGURE 4 Patent Application Publication May 19, 2016 Sheet 44 of 50 US 2016/013638.6 A1 & s : : s &::::::::::: ::::::::: 8:88: FIGURE 42 Patent Application Publication May 19, 2016 Sheet 45 of 50 US 2016/013638.6 A1 8x88 wo : : & I 8:8 x 8: 8x8. 8 : xxxx 3:38s:- : &i s: 8:8 88: :xx: 3:8:8: : 88888& FGURE 43 Patent Application Publication May 19, 2016 Sheet 46 of 50 US 2016/013638.6 A1 s &:::::::::::::::::::: 8:88 ki : ::::::8: 8:::::::8: 208, .88.88. 8:38. | FCURE 44 Patent Application Publication May 19, 2016 Sheet 47 of 50 US 2016/013638.6 A1 888:::::::::::::::: *:::::: 88 8: I 8 :8 *::::::::::: *:::::::::: X. ... :8:8 {{{: y v. ses : FIGURE 45 Patent Application Publication May 19, 2016 Sheet 48 of 50 US 2016/013638.6 A1 -888xx:y: 388 8:88-888xxxxy 8888. Is *:::::::::: 8xxxx $888xxxxy 8888 8:8; 8.8xxxxy 8888 8. 388. FIGURE 46 Patent Application Publication May 19, 2016 Sheet 49 of 50 US 2016/013638.6 A1 8xxx Patent Application Publication May 19, 2016 Sheet 50 of 50 US 2016/013638.6 A1 ? 88: US 2016/013638.6 A1 May 19, 2016 BOCERAMC COMPOSITIONS AND pectedly discovered numerous advantages of using the bio BIOMODULATORY USES THEREOF ceramic materials described hereinto complement or serve as the basis of a therapeutic approach for living organisms.
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