Lecture 1: Introduction Agenda: • Welcome to CS 238 — Algorithmic Techniques in Computational Biology • Official course information • Course description • Announcements • Basic concepts in molecular biology 1 Lecture 1: Introduction Official course information • Grading weights: – 50% assignments (3-4) – 50% participation, presentation, and course report. • Text and reference books: – T. Jiang, Y. Xu and M. Zhang (co-eds), Current Topics in Computational Biology, MIT Press, 2002. (co-published by Tsinghua University Press in China) – D. Gusfield, Algorithms for Strings, Trees, and Sequences: Computer Science and Computational Biology, Cambridge Press, 1997. – D. Krane and M. Raymer, Fundamental Concepts of Bioin- formatics, Benjamin Cummings, 2003. – P. Pevzner, Computational Molecular Biology: An Algo- rithmic Approach, 2000, the MIT Press. – M. Waterman, Introduction to Computational Biology: Maps, Sequences and Genomes, Chapman and Hall, 1995. – These notes (typeset by Guohui Lin and Tao Jiang). • Instructor: Tao Jiang – Surge Building 330, x82991,
[email protected] – Office hours: Tuesday & Thursday 3-4pm 2 Lecture 1: Introduction Course overview • Topics covered: – Biological background introduction – My research topics – Sequence homology search and comparison – Sequence structural comparison – string matching algorithms and suffix tree – Genome rearrangement – Protein structure and function prediction – Phylogenetic reconstruction * DNA sequencing, sequence assembly * Physical/restriction mapping * Prediction of regulatiory elements • Announcements: