Nasal Cycle Dilemma: Nasal Cycle Is Associated to Brain Wake/REM States Or Is Associated to Conscious State in Them?
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Open Journal of Biophysics, 2019, 9, 1-9 http://www.scirp.org/journal/ojbiphy ISSN Online: 2164-5396 ISSN Print: 2164-5388 Nasal Cycle Dilemma: Nasal Cycle Is Associated to Brain Wake/REM States or Is Associated to Conscious State in Them? Atanas Todorov Atanasov Department of Physics and Biophysics, Medical Faculty, Trakia University, Stara Zagora, Bulgaria How to cite this paper: Atanasov, A.T. Abstract (2019) Nasal Cycle Dilemma: Nasal Cycle Is Associated to Brain Wake/REM States or Experimental and theoretical arguments have been described in favor of the Is Associated to Conscious State in Them? hypothesis that the nasal cycle reversals of the nostril’s airflow occurs only in Open Journal of Biophysics, 9, 1-9. the consciousness states of the brain (during awake/wake state, REM state https://doi.org/10.4236/ojbiphy.2019.91001 and during dreams in St.1, 2 of the non-REM sleep). This finding gives possi- Received: October 17, 2017 bility to use nasal cycle as “marker for consciousness states”. An idea for clin- Accepted: December 14, 2018 ical application of the hypothesis is proposed. Published: December 17, 2018 Keywords Copyright © 2019 by author and Scientific Research Publishing Inc. Nasal Cycle, Sleep Cycle, Consciousness, EEG Waves This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ 1. Introduction Open Access The nasal cycle defines as switch of dominate nostril airflow from left to right side and reverse is well studied during diurnal period of the day over healthy persons in awake (wakefulness) consciousness state [1] [2]. During diurnal time, the periods of the nasal cycle may have duration between 1.0 and 5.0 hours with mean duration during wakefulness about 1.5 hours [3]. The diurnal nasal cycle has random pattern under influence of various psychophysical factors [4] [5] [6]. During the night sleep, the switch of the nostrils occurred nearly in the same in- terval with periodicity multiplies by one sleep cycle ~1.5 h. In this case, the mean duration of the nasal cycle is about 3 h with dominance of the 3 h nasal cycles (60%), 1.5 h nasal cycles (30%) and 1.5 h nasal cycles (10% from all cases) [7] [8]. The experimental studies of Atanasov et al. [7] [8] and Kimura et al. [9] have shown the nasal cycle during night sleep is mutually connected to REM stages of the sleep. The experimental results have shown the change of dominate nostril airflow occurs during one of the stages of REM sleep and never not happening DOI: 10.4236/ojbiphy.2019.91001 Dec. 17, 2018 1 Open Journal of Biophysics A. T. Atanasov during slow-wave sleep. The principal situation of the nasal cycle reversals (NCR) during diurnal and night (sleep) time is shown in Figure 1. The modern concept for wakefulness (awake/wake) and REM stage of the sleep is both to be considered as consciousness states [11] (see Figure 2). The consciousness is ambiguous concept, which is focused on multi-disciplinant de- bates concerning the cells sensation [12] and the animals psych functions [13]. However, up to now, there is no universal definition for consciousness covering all its essential characters. Recently, the awake/wake consciousness regard as “primary consciousness state”, wireless the REM stage of the sleep regard as “secondary consciousness state” or “proto-consciousness” state [11] [14]. The clinically defined consciousness is characterized by two main components-awareness and arousal [15]. The presence of one or both of these consciousness components gives reason to believe that the given person is in a consciousness or is near to consciousness state. During diurnal period of the day the healthy person normally is in waking consciousness. In this state of consciousness, the sensation and perception are Figure 1. Principal scheme of the nasal cycle reversal during wakefulness and REM stages of the sleep (unpublished data by Atanasov [7] [10]). (a) Record of the breathing streams through the left and right nostrils during diurnal (wakefulness) time and night (sleep) time. (b) Nasal cycle periodicity (arrows shows the moments of the nasal cycle reversals). Figure 2. The principal scheme of consciousness states of the brain. Legend: awake and REM consciousness refers to daytime and to sleep (dream) time, respectively. Sleep stages 1 and 2, which are neighboring to awake and REM stages are taken as consciousness states during dream. DOI: 10.4236/ojbiphy.2019.91001 2 Open Journal of Biophysics A. T. Atanasov vivid and externally generated. The thought is logical and progressive. The movement is continuous and voluntary. The characteristics of consciousness during night sleep are poorly studied. The sleep is divided to non-REM and REM stages, which alternate in a certain sequence forming about 1.5 hours pe- riods [16]. It is established that in REM “proto-consciousness” stage of the sleep there is reason to consider that there is “minimum threshold” of consciousness [11] [14]. In “REM proto-consciousness” the sensation and perceptions are vivid and internally generated, and the thought is illogical and bizarre. The movement is command but inhibited. Whatever, just in REM stages of the sleep, it becomes about 84% NCR between the nostrils [7] [8] [9]. During the non-REM stages of the sleep the sensation and perception are absent. If the sleeper is awakened from REM sleep, dream recall rates are very high, between 80 and 90 percent of the awakenings yield some kind of dream report [17]. Even after non-REM awakenings (in stage 2), some mental content has been reported quite often [18]. Some researchers [17] [18] advocate the hypothesis that the mind never sleeps, that is, dreaming of some kind is present during the entire sleep process. According to other authors [19], sleep that contains dream is considered as conscious state, while dreamless sleep is unconscious. Lucid dreams are reported far more often in REM sleep too [19] [20] [21]. In fact, the lucid dreams could be considered a hybrid state combining essential elements of REM sleep and wak- ing consciousness. Therefore, dreams are the event that defines the conscious- ness. The studies of Foulkes [22] and others researches [23] [24] [25] showed that dream-like mentation may occur during non-REM stage of sleep and more precisely in the neighborhood of the awake state St.1 and St.2 of sleep [25]. “Light sleepers” can experience dreaming during stage 2 non-REM sleep, whe- reas “deep sleepers”, upon awakening in the same stage, are more likely to report “thinking” but not “dreaming”. Despite this wealth of descriptive information about the stages of sleep, the functional purposes of the various sleep states are not known. Whereas most sleep researchers accept the idea that the purpose of non-REM sleep is at least in part restorative, the function of REM sleep remains a matter of considerable controversy. The main difference between REM and non-REM dream is the mental content of activity. However, the dreams in REM and non-REM sleep differ by many characteristics, and mean only 40% of vo- lunteers-sleepers associated dreaming with non-REM sleep [14] [17] [26] in comparison to mean 80% of sleepers associated dreaming with REM sleep [17] [26] [27]. Thus, the non-REM sleep can present some consciousness state in St.1, 2 of the sleep [27]. Figure 3 shows a principal scheme of connection between the consciousness states and NCR in humans. Recently, there is enough experimental evidence for association between the conscious states and NCR. Indeed, the association between the nasal cycle re- versals and awake/wake state and REM stages is well documented [7] [8] [9], while the connection between the NCR and St.1, 2 is under consideration. In the study of Atanasov et al. [7] 75% of the NCR are associated to REM sleep and DOI: 10.4236/ojbiphy.2019.91001 3 Open Journal of Biophysics A. T. Atanasov Figure 3. Cycle of the human consciousness. The wake stage is taken to be basic. The newborn to basic wake stages (REM and St.1, 2) are considered as “conscious states”. 25% are associated to other body factors. In the study of Kimura et al. [9] 68.8% of the NCR tended to be associated with REM sleep and 18.8% tended to be as- sociated to postural change in St.1, 2. The half of these 18.8% NCR are made in “left-right” body position and the other half of NCR are made in “supine” body position. But, it is documented [3] [9] [28] that the “supine” body position does not itself cause nasal cycle reversal, unlike “left” or “right” body position. From these results leads that the NCR can associate not only with postural changes, but also with St.1, 2 of the sleep and “dream-like mentation” in these stages. On Figure 3, the wake state of consciousness is taken to be “basic”, but in in- fants the REM stage appears “basic” state of the brain. In the premature neonates and normal newborns the REM stage can occupy from 50% to 80% of the day and constitutes the main state of the brain. In this case a wake and St.1, 2 are ad- jacent to the major REM stage. For mature peoples the basic brain stage appears an awake, while the REM stage constitutes about 25% of the sleep [29]. 2. Hypothesis The experiments showed that NCR can observe in awake/wake stage, in St.1, 2 and REM stage of the sleep. Just in these EEG stages certain characteristics of consciousness are retained during wake and dream.