Steve Jones Interviewed by Paul Merchant: Full Transcript of The
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Super-Curricular Suggestions
Super- curricular suggestions Strong applicants to Cambridge and other competitive universities tend to have explored their chosen subject through wider reading outside the classroom, as well as doing very well in their GCSEs and A-levels. We call this sort of exploration ‘super-curricular’, as it builds on and enhances what you are studying in school. We do not expect you to pay for this sort of exploration and have endeavoured to provide resources that are mostly freely available. This selection of suggested reading lists and resources has been gathered from the Cambridge departmental and College websites, other universities and other sources on the internet. These lists are certainly NOT ‘required reading’ for Cambridge applicants. They simply provide some suggestions for places to start exploring your own interests in your chosen subject independently - you do not need to engage with any of the specific websites, books, podcasts etc mentioned and can easily find your own alternatives. The following lists are suggestions only. It is important to read critically by thinking carefully about the arguments, assumptions and evidence presented by the author. Reading is a great way to explore subjects that you find interesting – but there are many other ways to deepen your understanding: investigate your local museums, monuments, galleries and natural features, and think analytically about nature, machinery or the built environment. After the COVID-19 lockdown, perhaps you can visit some of these! The best thing about super-curricular activities is that there are no exams or deadlines to worry about – you are free to follow your own lines of enquiry into the areas that interest you the most. -
Reinhart Heinrich (1946–2006) Pioneer in Systems Biology
NEWS & VIEWS NATURE|Vol 444|7 December 2006 OBITUARY Reinhart Heinrich (1946–2006) Pioneer in systems biology. In biology, mathematical systems analysis where he showed that the flux of was until recently nearly invisible in the reaction was shared by several the dazzling light of twentieth-century enzymes. Much later, he extended discoveries. But it has emerged from the his ideas to signal-transduction shadows in the field of systems biology, pathways, introducing control a subject buoyed by immense data sets, coefficients to dynamic processes. conveyed by heavy computing power, and Sticking to real examples, such as addressing seemingly incomprehensible the Wnt signalling and MAP kinase forms of complexity. If systems biology has pathways, he again demonstrated heroes, one of them is Reinhart Heinrich, a that new properties and constraints former professor at the Humboldt University emerge when the individual steps in Berlin, who died on 23 October, aged are combined into a complete 60. His most famous accomplishment was pathway. metabolic control theory, published in Heinrich also pointed the way to 1974 with Tom Rapoport and formulated considerations of optimality theory independently by Henrik Kacser and James and evolution that will confront A. Burns in Edinburgh, UK. systems biology for the next From the 1930s to the 1960s, biochemists century. The question of evolution were busy describing metabolic pathways, lies just beneath any effort to just as molecular biologists today are understand biology. Yet in most feverishly trying to inventory the cell’s cases, physiological function and gene-transcription and signalling circuits. evolutionary change are considered The basic kinetic features of the enzymes in distinct and are investigated by the major pathways were studied in great different people. -
Radio 4 Listings for 2 – 8 May 2020 Page 1 of 14
Radio 4 Listings for 2 – 8 May 2020 Page 1 of 14 SATURDAY 02 MAY 2020 Professor Martin Ashley, Consultant in Restorative Dentistry at panel of culinary experts from their kitchens at home - Tim the University Dental Hospital of Manchester, is on hand to Anderson, Andi Oliver, Jeremy Pang and Dr Zoe Laughlin SAT 00:00 Midnight News (m000hq2x) separate the science fact from the science fiction. answer questions sent in via email and social media. The latest news and weather forecast from BBC Radio 4. Presenter: Greg Foot This week, the panellists discuss the perfect fry-up, including Producer: Beth Eastwood whether or not the tomato has a place on the plate, and SAT 00:30 Intrigue (m0009t2b) recommend uses for tinned tuna (that aren't a pasta bake). Tunnel 29 SAT 06:00 News and Papers (m000htmx) Producer: Hannah Newton 10: The Shoes The latest news headlines. Including the weather and a look at Assistant Producer: Rosie Merotra the papers. “I started dancing with Eveline.” A final twist in the final A Somethin' Else production for BBC Radio 4 chapter. SAT 06:07 Open Country (m000hpdg) Thirty years after the fall of the Berlin Wall, Helena Merriman Closed Country: A Spring Audio-Diary with Brett Westwood SAT 11:00 The Week in Westminster (m000j0kg) tells the extraordinary true story of a man who dug a tunnel into Radio 4's assessment of developments at Westminster the East, right under the feet of border guards, to help friends, It seems hard to believe, when so many of us are coping with family and strangers escape. -
Fitness As a Function of Β-Galactosidase Activity In
Genet. Res., Camb. (1986), 48, pp. 1-8 With 3 text-figures Printed in Great Britain Fitness as a function of /?-galactosidase activity in Escherichia coli ANTONY M. DEAN, DANIEL E. DYKHUIZEN AND DANIEL L. HARTL Department of Genetics, Washington University School of Medicine, St Louis, Missouri USA 63110-1095 (Received 12 July 1985 and in revised form 13 January 1986) Summary Chemostat cultures in which the limiting nutrient was lactose have been used to study the relative growth rate of Escherichia coli in relation to the enzyme activity of /?-galactosidase. A novel genetic procedure was employed in order to obtain amino acid substitutions within the /acZ-encoded /?-galactosidase that result in differences in enzyme activity too small to be detected by ordinary mutant screens. The cryptic substitutions were obtained as spontaneous revertants of nonsense mutations within the lacZ gene, and the enzymes differing from wild type were identified by means of polyacrylamide gel electrophoresis or thermal denaturation studies. The relation between enzyme activity and growth rate of these and other mutants supports a model of intermediary metabolism in which the flux of substrate through a metabolic pathway is represented by a concave function of the activity of any enzyme in the pathway. The consequence is that small differences in enzyme activity from wild type result in even smaller changes in fitness. 1. Introduction sidase activity and growth rate in E. coli, together with a novel genetic technique for obtaining amino acid In the seminal paper, Kacser & Burns (1973) demon- strated that the net flux through a simple linear meta- substitutions that result in electrophoretic or thermo- bolic pathway should be a concave function of the lability differences from wild type. -
Radio 4 Listings for 12 – 18 January 2013 Page
Radio 4 Listings for 12 – 18 January 2013 Page 1 of 16 SATURDAY 12 JANUARY 2013 Grade 2 listed buildings but some have been destroyed by fire Dublin and others virtually abandoned by owners who can't afford the SAT 00:00 Midnight News (b01pp62f) development work. He helps assess one of the buildings with When the writer Joseph O'Connor was a child, his mother The latest national and international news from BBC Radio 4. experts from English Heritage who want to produce a database would take him for walks around their Dublin neighbourhood, Followed by Weather. on the state of Grade 2 listed buildings. and point out where James Joyce and John Synge had lived and Jules also explores nearby Middleton Hall which was so worked. neglected it was used as a motorbike track. Volunteers set up a SAT 00:30 Book of the Week (b01px4q3) trust and have spent 35 years bringing it back into use. "I grew up in Dun Laoghaire, a coastal town 8 miles south of The Examined Life However, they say their work is still not done. Dublin city where there was a pier and a waterfront, and the nightly entertainment in the summer when you were a teenager Episode 5 Produced by Anne-Marie Bullock. was to walk down the pier and look at the boats and the ferries leaving for London and wonder to yourself would you go to The world bedevils us. To make sense of it, we tell ourselves Manchester or Coventry. There was no notion that you'd stay in stories. -
Jocelyn Bell Burnell
DAME JOCELYN BELL BURNETT Dame Jocelyn Bell Burnell Jocelyn is a Northern Irish born astrophysicist and astronomer, with a lifetime of inspiring scientific leadership in research, education and public service. Born 1943 in Lurgan to Quaker parents. Didn’t excel at Lurgan College, where girls were supposed to study less academic subjects. Aged 13, her parents sent her to The Mount School, York, a Quaker boarding school, where she flourished. She then went to Glasgow University, followed by post- grad studies in radio-astronomy at New Hall, Cambridge. Part of a team which built the 4-acre radio telescope to monitor quasers. Jocelyn painstakingly analysed reams of paper output, spotting curious signals in the data which were discovered to be a new type of object, later named pulsars. Findings published in 1968, with Jocelyn’s name second on the paper, to huge media interest: her supervisor was asked about astrophysics, Jocelyn quizzed about boyfriends and hair colour! The 2 senior professors awarded Nobel Prize for the discovery, which Jocelyn accepted with good grace. Married to a civil servant, Jocelyn had to move around the country with him, so worked at Southampton, London, and Edinburgh, and also from 1973 working with the Open University, where in 1991 she became Professor of Physics, doubling the number of women physics professors in the UK. Jocelyn has received numerous accolades and awards, becoming a Dame in 2007 for her services to astronomy. In 2018 she received a Special Breakthrough Prize in Fundamental Physics, and donated all the £2.3 million prize money to the Bell Burnell Graduate Scholarship Fund which assists female, ethnic minority and refugee students in their research. -
Uva-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Henrik Kacser 1918-1995: Metabolism of control. Westerhoff, H.V. DOI 10.1016/S0167-7799(00)88956-8 Publication date 1995 Published in Trends in Biotechnology Link to publication Citation for published version (APA): Westerhoff, H. V. (1995). Henrik Kacser 1918-1995: Metabolism of control. Trends in Biotechnology, 13, 245. https://doi.org/10.1016/S0167-7799(00)88956-8 General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:25 Sep 2021 245 f orum Henrik Kacser (19184995): metabolism of control Obituary Henrik Kacser has been referred missed the rate-limiting step. He funding agency had allowed much to as the ‘pope’ of Metabolic much appreciated -
Home As Archive - Event Transcript
Home As Archive - Event Transcript Event begins Title Slide: Pink background with white text that reads “Home as Archive: Presented in collaboration with Essex Book Festival & Metals Culture, Southend. EWF logo and festival dates are in the lower right corner” Video One: Katerina Bryant Welcome to Home as Archive. My name is Katerina and I will be a host and artist this evening. To begin, I would like to acknowledge the first nations and Traditional Owners of the land we are broadcasting from – I am currently on Kaurna land, where I live and write. I pay my respects to Elders past and present, and, as this is an online recording whose reach is far, to the Elders of the lands this recording might reach. For this event, we will be discussing home, spaces and histories. This is part of the wonderful EWF and is presented in collaboration with Essex Book Festival & Metal Culture, Southend. Tonight, we will be witnessing work by artists working between so-called Australia and Essex, England. They will be sharing artefacts from the archives of their personal histories. I anticipate there will be an intimacy tonight as we will be peering into these artists’ homes. Where we live and, who and what we share those spaces with, is intimate and vulnerable. In some ways the past year has allowed us to peer into each other’s homes over Zoom, but in others it has separated us from sharing space with people we cherish. I’d love to frame tonight as not only a look into these artist’s homes and lives but the creation of our own archive – capturing this moment through place and objects. -
Emergency in Thehighlands
www.ihwebsite.com | facebook.com/highlands.council March 2013 EMERGENCY IN THE HIGHLANDS By Nina Milligan with Maureen Bondor, Highlands Resident of the original “Cottages” neighborhood of an emergency; I don’t like feeling helpless when CERT members learn to help themselves and Are you ready? it is so easy these days to get the basics squared others! The program only runs twice a year and away,” explains Maureen. “Even basic the spring program has two classes beginning on Thanks to Maureen and Michael preparedness (hey that’s about two March 13, 2013. Bondor, IH residents of the original “Cottages” weeks) brings great neighborhood, Issaquah Highlands has many peace of mind. It is an 8-week course, costing only $35. It is CERT-certified neighbors: 40 to 50 at last count. Just go to training that is invaluable and can affect many Maureen and Michael are virtual evangelists when Costco and get people’s lives including your own. Details and it comes to CERT training. But what is CERT it done!” registration can be found at anyway? http://issaquahcitizencorps.com/ We all think CERT stands for Community Emergency about fire, Through CERT Training you learn: Response Team (CERT) and is part of Issaquah earthquake and Disaster First Aid Training Citizen Corps, a volunteer organization dedicated in greater Issaquah, flooding, Disaster Preparedness to helping neighbors be better prepared for as the big threats to our safety. But Basic Firefighting disasters and emergencies. Issaquah’s CERT Maureen says there’s more. “Power Light Search and Rescue program -
Scientific Programme
10TH EFORT CONGRESS VIENNA, AUSTRIA 3 – 6 JUNE 2009 OFFICIAL PROGRAMME Level –1: Rooms D, G, H, K, P Level 0: Rooms E1, E2, F1, F2 Level 1: Rooms L, N, J EFORT – JOINT EFFORTS CONTENTS WELCOME ADDRESS INDUSTRY & EXHIBITION Message from the President of EFORT 3 Industry partners of the 10th EFORT Congress 155 Message from the Chairman of the Local Organising Exhibition Floor Plans 156 – 157 Committee 4 Exhibitors List 159 – 160 Welcome Address from the Chairman of the Scientifi c Committee 5 Company descriptions and contact details 161 – 202 OVERVIEW & HIGHLIGHTS SOCIETIES Colour guide per topic 7 National Member Societies 205 – 206 Collaborating Speciality Societies and SESSION OVERVIEW & ABSTRACT INFORMATION Affi liated Organisations with own Sessions 207 Symposia 9 – 10 Instructional course lecture 10 – 11 GENERAL CONGRESS INFORMATION Controversial case discussion 12 Social programme 209 ExMEx 12 – 13 About the host city 210 Guest societies and other sessions 13 – 14 General congress information 211 – 213 Satellite symposia 15 – 16 City map 214 Free paper sessions 16 – 20 Public transportation map 215 Number of abstracts by category 21 Floor plans 216 – 217 Number of abstracts by country 22 Abstract reviewers 23 – 24 ABOUT EFORT EFORT Committees 219 – 220 WEDNESDAY 3 JUNE 09 About EFORT 221 – 222 Programme of the day 27 – 61 EFORT Advanced Training Programme 223 EFORT Fora 224 THURSDAY 4 JUNE 09 Programme of the day 63 – 95 E-POSTERS & INDEX List of e-posters 225 – 331 FRIDAY 5 JUNE 09 Index of authors 332 – 361 Programme of the day 97 – 131 SATURDAY 6 JUNE 09 Programme of the day 133 – 152 Published by textbildtechnik.ch 1 MESSAGE FROM THE PRESIDENT OF EFORT Karl-Göran Thorngren EFORT President Dear Colleagues, This year we will all meet for the EFORT Congress in Vienna. -
If You Lived Here You'd Be Home By
IF YOU LIVED HERE YOU’D BE HOME BY NOW by Lydia A. Cyrus A Thesis Submitted to the Faculty of Purdue University In Partial Fulfillment of the Requirements for the degree of Master of Fine Arts Department of English West Lafayette, Indiana May 2021 THE PURDUE UNIVERSITY GRADUATE SCHOOL STATEMENT OF COMMITTEE APPROVAL Terese Mailhot, Chair Department of English Brian Leung Department of English Dr. Kaveh Akbar Department of English Approved by: Dr. Dorsey Armstrong 2 for my mother who gave up everything to be mine 3 ACKNOWLEDGMENTS An incredible amount of gratitude to Poets & Writers Magazine for choosing a portion of my thesis as the 2019 fiction winner of the Maureen Egen Writers Exchange award. A swell of gratitude to my instructors at Purdue University. For saying yes and pushing me to write the way I wanted to. For teaching me how to write better, best. Thank you to Brian Leung and Sharon Solwitz for saying yes in the beginning. Thank you to Terese Mailhot for being the writer and educator to change so much for me and for showing me what gifts lay within my ability to write. Thank you to Don Platt, Kaveh Akbar, and Paige Lewis for accepting me and making me feel seen and heard and cared for even if I was a prose writer. Thank you to my workshop partners who read everything. Diana Clarke, Hannah Dellabella, Steven Dawson, Brian Czyzk, Katie McMorris, Kelsey Wort, Aaron M Dell, Lucas Hunter, Daschielle Louis, and Andy Nellis. Thank you to the folks outside of the MFA for being my family away from home: Erin Brock Carlson and Amanda Smith especially. -
'Almost Like a Whale' by Steve Jones
5/4/2018 Andrew Berry reviews ‘Almost like a Whale’ by Steve Jones · LRB 3 February 2000 Back to article page Data Guy Andrew Berry Almost like a Whale: ‘The Origin of Species’ Updated by Steve Jones Doubleday, 402 pp, £20.00, September 1999, ISBN 0 385 40985 0 In the introduction to Almost like a Whale, Steve Jones calls The Origin of Species ‘without doubt, the book of the millennium’. Jones is an evolutionary biologist, so this judgment could merely reflect disciplinary bias. But not only did The Origin of Species disabuse us of the notion that we humans are in some way set apart from the natural world, it also provided a mechanism, natural selection, to explain how the exquisite fit of organisms to their environment can arise without divine intervention: man deposed, God disposed of, and all in a single volume. Almost like a Whale is Jones’s update of The Origin of Species. He has followed the basic structure of the book, even retaining the subheadings, and written a modern treatment of each topic. It is thus not a simple revision of the original: Jones has done more than merely correct Darwin’s mistakes. Rather, he has written his own book about evolution, but draped it over what Darwin himself referred to as his ‘one long argument’. The product is a hybrid: part Darwin, part Jones. It has also created a new genre of literature, the non-fiction rewrite. It’s not entirely clear why Jones undertook this eccentric project. He points out that The Origin of Species is ‘a work of high Victorian seriousness’ but himself adopts a tone more in keeping with what he calls ‘these more flippant times’.