DOCSLIB.ORG

Traditional Medicinals and Cancer Lynn Stephenson, Product Specialist, Sigma® Life Science Chloe Mcclanahan, Product Manager, Sigma Life Science

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Traditional Medicinals and Cancer Lynn Stephenson, Product Specialist, Sigma® Life Science Chloe Mcclanahan, Product Manager, Sigma Life Science Your Biology Resource Volume 8 | No. 6 Traditional Medicinals and Cancer Lynn Stephenson, Product Specialist, Sigma® Life Science Chloe McClanahan, Product Manager, Sigma Life Science Traditional Chinese Medicine (TCM) is a healing art that has been is a common mechanistic endpoint of many effective anti-cancer practiced for thousands of years. The practice of TCM is a holistic therapies. Within the TCM compounds that have been isolated, approach that includes the use of herbal preparations, acupuncture, induction of apoptosis is the most common mechanism by which and dietary therapy with the goal of returning the body to a healthy, TCM-derived compounds elicit their anti-tumor effects.1,4 For example, balanced state. Under TCM theory, cancer is a disease that arises Cantharidin, isolated from the Chinese Blister beetle, has been reported due to disturbances in the body from both endogenous physical to induce apoptosis in a variety of tumor cell lines including human conditions and exogenous pathogenic stresses and the goal of therapy leukemic, colon cancer, and human hepatoma, most likely through is on restoring the body’s natural defenses.1 Herbal preparations are inhibition of protein phosphatase 2A (PP2A).5 Of the compounds a common component of TCM and there has been an increase in studied to date that have shown anti-tumor effects, the vast majority research interest in understanding the molecular mechanisms by induce apoptosis, primarily through the regulation of apoptotic which many of these medicinal herbs elicit their effects with the hope signaling molecules.1 These studies are helping to validate that many that these can be translated into new therapies. Many commonly used of the compounds used in TCM have true biological effects that may drugs in cancer treatment, for example paclitaxel and camptothecin, be translated into new therapeutics. are derived from natural sources and TCM, with over 7,000 herbs, The materia medica of traditional medicinal systems represent a rich represents a rich source of potential new compounds.2 source of time-tested therapeutics and thus, an excellent source of potential new bioactive molecules. In particular, pharmaceutical companies have been investigating compounds isolated from medicinal herbs as a potential source of new lead compounds for drug discovery. TCM has been the source of many new drugs including artemisinin, camptothecin, triptolizde, and ephedrine.6 The discovery of camptothecin highlights the tremendous potential that can be gained from research into plant compounds. Camptothecin, a cytotoxic topoisomerase inhibitor, is found in the Chinese happy tree (Camptotheca acuminate) which was of research interest because it has been used in TCM formulations for thousands of years. This discovery resulted from a cross-discipline research program between botanists at the USDA and chemists at the National Cancer Institute (NCI) during the 1960s.7 Camptothecin analogs were eventually made available as pharmaceuticals for the treatment of various cancer types. Jars of ginseng root typically seen in a TCM pharmacy. Ginseng extracts contain a class of bioactive During the 1960s, Research Triangle Institute developed innovative saponins termed ginsenosides that have been shown to reverse multi-drug resistance in methods for plant extract fractionation and subsequent in vitro chemotherapy research. cytotoxicity testing of isolated compounds.7 These methods, derived Recent work has begun to unravel the molecular mechanisms by from a reductionist research approach, were critical to camptothecin which many TCM-derived compounds elicit their antitumor effects. The discovery but most TCM formulas are based on the synergistic effects targets of these compounds tend to broadly fall into three categories, of multiple components, each containing many potentially bioactive those targeting topoisomerases, those inducing apoptosis, and those disrupting oncogenic signaling pathways.1 Resistance to apoptosis is a common hallmark of cancer cells3 and induction of apoptosis Your Biology Resource Traditional Medicinals and Cancer | Volume 8 No. 6 ingredients. Recent research is indicating that a systems biology or Cat. No. Product Description network biology approach may be a better course for understanding L9283 Luteolin the combinatorial effects of compounds within a TCM preparation. O9639 Oridonin Advances in instrumentation are enabling researchers to integrate P0020 Pristimerin chemical identification, pharmacological, metabolomics, and T3652 Triptolide bioinformatics data from herbal preparations. Analysts at the University W0769 Wogonin of Copenhagen used a new platform that combines HPLC and NMR chemical identification with a metabolomics-based radical scavenging C7632 Cantharidin assay to determine both the chemical and pharmacological fingerprint R7269 Rhein of a willow bark extract. Willow bark has been applied historically in Z3902 Zerumbone TCM as an analgesic but it also exhibits anti-proliferative activity and O0641 Oroxylin A induces apoptosis in vitro.8-9 I3766 Isoliquiritigenin A1010 Arsenic(III) oxide Sigma offers a unique portfolio of high-purity secondary metabolites derived from Traditional Chinese Medicinal herbs that may be applied S3757 a-Solanine individually in cancer screening assays or as benchmarks in complex H35803 Paeonol biological network analysis. 361593 Artemisinin A3731 Artesunate 94121 Baicalin C7727 Curcumin M5319 Matrine L8170 Pseudolaric Acid B S7576 Shikonin T4952 Tanshinone IIA S0327 Scutellarein B0189 Casticin R4033 Rosmarinic Acid D7321 Diosmetin O0891 Oxymatrine M3824 alpha-Mangostin T5330 Tanshinone I D0947 Dihydrotanshinone I P0023 Punicalagin The fruit hull from mangosteens are used in TCM as an anti-inflammatory treatment. A2987 Atractylenolide III γ-Mangostin and α-Mangostin (Sigma Cat. Nos. M6824 and M3824), xanthones isolated from mangosteen, have been shown to have anti-cancer activity, specifically cytotoxicity, apoptosis, and B9938 Calycosin anti-tumorigenicity. M6699 Maslinic Acid N3915 Notoginsenoside R1 Key Products SML0184 Ginsenoside Rg3 Cat. No. Product Description G0777 Ginsenoside-Rb1 from Panax ginseng D7439 Dihydroartemisinin (Korean ginseng) root B0261 Bufalin G1027 Ginsenoside-Re from Panax ginseng (Korean ginseng) root C9911 Camptothecin G0902 Ginsenoside-Rc from Panax ginseng C0869 Celastrol (Korean ginseng) root A9361 Artemether G8171 Gambogic acid SML0280 Indirubin Your Biology Resource Traditional Medicinals and Cancer | Volume 8 No. 6 References 1. Hsiao, W. L. W. and Liu, L. The Role of Traditional Chinese Herbal Medicines in Cancer Therapy - from TCM Theory to Mechanistic Insights. Planta Med, 76, 1118-1131 (2010). 2. Parry, J. Taking a New Look at an Ancient Tradition. The Scientist 19, (2005). 3. Hanahan, D. and Weinberg, W. Hallmarks of Cancer: The Next Generation. Cell, 144, 646- 674 (2011). 4. Parekh, H.S. et al. A New Dawn for the Use of Traditional Chinese Medicine in Cancer Therapy. Mol. Cancer, 8, 21 (2009). 5. Youns, M. et al. Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours. Curr. Drug Disc Technol. 7, 2-12 (2010). 6. Li, X.-J., et al. Chemoinformatics Approaches for Traditional Chinese Medicine Research and Case Application in Anticancer Drug Discovery. Curr. Drug Disc Technol. 7, 22-31, (2010). Curcumin (Sigma Cat. No. C1386) is a natural phenolic compound isolated from the medicinal 7. Ginsberg, J. The Discovery of Capmptothecin and Taxol. In plant turmeric. It has been studied as a potential chemotherapeutic. American Chemical Society Education. Retrieved November 5, 2012 from http://portal.acs.org/portal/acs/corg/ content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_ id=926&content_id=CTP_004450&use_sec=true&sec_url var=region1. 8. Afnolet, S. et al. Comprehensive analysis of commercial willow bark extracts by new technology platform: Combined use of metabolomics, high-performance liquid chromatography-solid- phase extraction-nuclear magnetic resonance spectroscopy and high-resolution radical scavenging assay. J. Chromatogr. 1262, 130-137, (2012). 9. Hostanka, K. et al. Willow Bark Extract (BNO1455) and its Fractions Suppress Growth and Induce Apoptosis in Human Colon and Lung Cancer Cells. Cancer Detect. Prev. 31, 129-139 (2007). ©2013 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA and SIGMA-ALDRICH are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. Where bio begins is a trademark of Sigma-Aldrich Co. LLC. Sigma brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/ or on the reverse side of the invoice or packing slip. sh6060 1013.
Load more

Recommended publications
  • Flavonoid Application in Treatment of Oral Cancer-A Review
    European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 07, Issue 01, 2020 FLAVONOID APPLICATION IN TREATMENT OF ORAL CANCER-A REVIEW Sudarsan R1, Lakshmi T2, Anjaneyulu K3 1Undergraduate student, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 77 2Associate Professor, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 77 3 Reader, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 77 ABSTRACT A wide range of organic compounds that are naturally occurring called flavonoids are primarily found in a large variety of plants. Some of the sources include tea, wine, fruits, grains, nuts and vegetables. There are a number of studies that have proven that a strong association exists between intake of dietary flavonoid and its effects on mortality in the long run. Flavonoids at non-toxic concentrations are known to demonstrate a wide range of therapeutic biological activities in organisms. The contribution of flavonoids in prevention of cancer is an area of great interest in current research. A variety of studies, including in vitro experiments and human trials and even epidemiological investigations, provide compelling evidence which imply that flavonoids’ effects on cancer in terms of chemoprevention and chemotherapy is significant. As the current treatment methods possess a number of drawbacks, the anticancer potential demonstrated by flavonoids makes them a reliable alternative. Various studies have focussed on flavonoids’ anti-cancer potential and its possible application in the treatment of cancer as a chemopreventive agent.
    [Show full text]
  • Identification of Apigenin and Luteolin in Artemisia Annua L. for the Quality
    Phadungrakwittaya et al. Identification of Apigenin and Luteolin inArtemisia annua L. for the Quality Control Rattana Phadungrakwittaya*, Sirikul Chotewuttakorn*, Manoon Piwtong**, Onusa Thamsermsang**, Tawee Laohapand**, Pravit Akarasereenont*,** *Department of Pharmacology, **Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. ABSTRACT Objective: To identify active compounds and establish the chemical fingerprint ofArtemisia annua L. for the quality control. Methods: Thin-layer chromatography (TLC) conditions were developed to screen for 2 common flavonoids (apigenin and luteolin). Three mobile phases were used to isolate these flavonoids in 80% ethanolic extract of A. annua. Hexane : ethyl acetate : acetic acid (31:14:5, v/v) and toluene : 1,4-dioxane : acetic acid (90:25:4, v/v) were used in normal phase TLC (NP-TLC), and 5.5% formic acid in water : methanol (50:50, v/v) were used in reverse phase TLC (RP-TLC). Chromatograms were visualized under visible light after spraying with Fast Blue B Salt. Apigenin and luteolin bands were checked by comparing their Rf values and UV-Vis absorption spectra with reference markers. Results: Apigenin and luteolin were simultaneously detected with good specificity in RP-TLC condition, while only apigenin was detected in NP-TLC condition. Apigenin band intensity was higher than luteolin band intensity in both conditions. Conclusion: This knowledge can be applied to the development of quality control assessments to ensure product efficacy and consistency. Keywords: Artemisia annua L.; TLC fingerprint; apigenin; luteolin (Siriraj Med J 2019;71: 240-245) INTRODUCTION Thai herbal recipes that are published in The National Artemisia annua L., commonly known as sweet List of Essential Medicines.2 Several previous studies wormwood, is an annual plant in the Asteraceae (Compositae) reported that A.
    [Show full text]
  • The Phytochemistry of Cherokee Aromatic Medicinal Plants
    medicines Review The Phytochemistry of Cherokee Aromatic Medicinal Plants William N. Setzer 1,2 1 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]; Tel.: +1-256-824-6519 2 Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA Received: 25 October 2018; Accepted: 8 November 2018; Published: 12 November 2018 Abstract: Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines. Keywords: Cherokee; Native American; traditional herbal medicine; chemical constituents; pharmacology 1. Introduction Natural products have been an important source of medicinal agents throughout history and modern medicine continues to rely on traditional knowledge for treatment of human maladies [1]. Traditional medicines such as Traditional Chinese Medicine [2], Ayurvedic [3], and medicinal plants from Latin America [4] have proven to be rich resources of biologically active compounds and potential new drugs.
    [Show full text]
  • Herbal Principles in Cosmetics Properties and Mechanisms of Action Traditional Herbal Medicines for Modern Times
    Traditional Herbal Medicines for Modern Times Herbal Principles in Cosmetics Properties and Mechanisms of Action Traditional Herbal Medicines for Modern Times Each volume in this series provides academia, health sciences, and the herbal medicines industry with in-depth coverage of the herbal remedies for infectious diseases, certain medical conditions, or the plant medicines of a particular country. Series Editor: Dr. Roland Hardman Volume 1 Shengmai San, edited by Kam-Ming Ko Volume 2 Rasayana: Ayurvedic Herbs for Rejuvenation and Longevity, by H.S. Puri Volume 3 Sho-Saiko-To: (Xiao-Chai-Hu-Tang) Scientific Evaluation and Clinical Applications, by Yukio Ogihara and Masaki Aburada Volume 4 Traditional Medicinal Plants and Malaria, edited by Merlin Willcox, Gerard Bodeker, and Philippe Rasoanaivo Volume 5 Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications, edited by Haruki Yamada and Ikuo Saiki Volume 6 Traditional Medicines for Modern Times: Antidiabetic Plants, edited by Amala Soumyanath Volume 7 Bupleurum Species: Scientific Evaluation and Clinical Applications, edited by Sheng-Li Pan Traditional Herbal Medicines for Modern Times Herbal Principles in Cosmetics Properties and Mechanisms of Action Bruno Burlando, Luisella Verotta, Laura Cornara, and Elisa Bottini-Massa Cover art design by Carlo Del Vecchio. CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2010 by Taylor and Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-13: 978-1-4398-1214-3 (Ebook-PDF) This book contains information obtained from authentic and highly regarded sources.
    [Show full text]
  • Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MA
    Int. J. Biol. Sci. 2016, Vol. 12 72 Ivyspring International Publisher International Journal of Biological Sciences 2016; 12(1): 72-86. doi: 10.7150/ijbs.13188 Research Paper Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways Hongming Lv1#, Zhenxiang Yu2#, Yuwei Zheng1, Lidong Wang1, Xiaofeng Qin1, Genhong Cheng1, Xinxin Ci1 1. Institute of Translational Medicine, The First Hospital of Jilin University, College of Veterinary Medicine, Jilin University, Changchun, China 2. Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China. # These authors contributed equally to this work. Corresponding author: X.-X.Ci, Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, 130001, China. Tel.: +86 431 88783044; E-mail addresses: [email protected] (X.-X.Ci.) © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions. Received: 2015.07.08; Accepted: 2015.11.02; Published: 2016.01.01 Abstract Oxidative damage and inflammation are closely associated with the pathogenesis of acute lung injury (ALI). Thus, we explored the protective effect of isovitexin (IV), a glycosylflavonoid, in the context of ALI. To accomplish this, we created in vitro and in vivo models by respectively exposing macrophages to lipopolysaccharide (LPS) and using LPS to induce ALI in mice. In vitro, our results showed that IV treatment reduced LPS-induced pro-inflammatory cytokine secretion, iNOS and COX-2 expression and decreased the generation of ROS.
    [Show full text]
  • Antineoplastic Potential of the Vitex Species: an Overview
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas BOLETÍN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMÁTICAS 17 (5): 492 - 502 (2018) © / ISSN 0717 7917 / www.blacpma.usach.cl Revisión | Review Antineoplastic potential of the Vitex species: An overview [Potencial antineoplásico de la especie Vitex: una visión general] Manisha Nigam1, Sarla Saklani2, Sergey Plygun3,4 & Abhay Prakash Mishra2 1Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, 246174, Uttarakhand, India 2Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, 246174, Uttarakhand, India 3All Russian Research Institute of Phytopathology, Moscow Region, Russia 4European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland Contactos | Contacts: Abhay Prakash MISHRA - E-mail address: [email protected] Abstract: Irrespective of progressive treatments, cancer remains to have the utmost rate of treatment failure due to numerous reasons associated. In recent years, the use of traditional medicine in cancer research has established considerable interest. Natural products represent an amazing source for cancer therapy and combating associated side-effects. More than thousand plants have been found to possess significant anticancer properties. Vitex is the largest genus in the family Lamiaceae which comprises 250 species distributed throughout world and several species have been reported to have anticancer properties. Despite a long tradition of use of some species, the genus has not been explored properly in terms of its anticancer profile. Here we are reporting the updated knowledge of the antineoplastic profile of this genus available so far.
    [Show full text]
  • Flavonoids from Artemisia Annua L. As Antioxidants and Their Potential Synergism with Artemisinin Against Malaria and Cancer
    Molecules 2010, 15, 3135-3170; doi:10.3390/molecules15053135 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer 1, 2 3 4 Jorge F.S. Ferreira *, Devanand L. Luthria , Tomikazu Sasaki and Arne Heyerick 1 USDA-ARS, Appalachian Farming Systems Research Center, 1224 Airport Rd., Beaver, WV 25813, USA 2 USDA-ARS, Food Composition and Methods Development Lab, 10300 Baltimore Ave,. Bldg 161 BARC-East, Beltsville, MD 20705-2350, USA; E-Mail: [email protected] (D.L.L.) 3 Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA; E-Mail: [email protected] (T.S.) 4 Laboratory of Pharmacognosy and Phytochemistry, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium; E-Mail: [email protected] (A.H.) * Author to whom correspondence should be addressed; E-Mail: [email protected]. Received: 26 January 2010; in revised form: 8 April 2010 / Accepted: 19 April 2010 / Published: 29 April 2010 Abstract: Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin. Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate. Artemisinin per se has not been used in mainstream clinical practice due to its poor bioavailability when compared to its analogs. In the past decade, the work with artemisinin-based compounds has expanded to their anti-cancer properties.
    [Show full text]
  • Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease
    Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 8871105, 10 pages https://doi.org/10.1155/2020/8871105 Review Article Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease Yang Yang ,1 Xin Jin ,2 Xinyi Jiao ,1 Jinjing Li ,1 Liuyi Liang ,1 Yuanyuan Ma ,1 Rui Liu ,1 and Zheng Li 1 1State Key Laboratory of Component-Based Chinese Medicine, College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 2Military Medicine Section, Logistics University of Chinese People’s Armed Police Force, Tianjin 300309, China Correspondence should be addressed to Rui Liu; [email protected] and Zheng Li; [email protected] Received 13 August 2020; Revised 11 December 2020; Accepted 15 December 2020; Published 31 December 2020 Academic Editor: Ihsan Ul Haq Copyright © 2020 Yang Yang et al. ,is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. ,e conventional therapies remain palliative and have various undesired effects. Flavonoids from traditional Chinese medicine (TCM) have been proved to exert protective effects on COPD. ,is review aims to illuminate the poly-pharmacological properties of flavonoids in treating COPD based on laboratory evidences and clinical data and points out possible molecular mechanisms. Animal/laboratory studies and randomised clinical trials about administration of flavonoids from TCM for treating COPD from January 2010 to October 2020 were identified and collected, with the following terms: chronic obstructive pulmonary disease or chronic respiratory disease or inflammatory lung disease, and flavonoid or nature product or traditional Chinese medicine.
    [Show full text]
  • Katalog Phytoplan 2004 Referenzsubstanzen
    Version 1/2006 PHYTOPLAN® Pflanzliche Wirkstoffe und AnalytikI Product List 2006 Reference Substances Natural Compounds PHYTOPLAN Diehm & Neuberger GmbH Im Neuenheimer Feld 519 69120 Heidelberg Germany Phone: +49 62 21 / 40 13 47 Fax: +49 62 21 / 43 76 64 e-Mail: [email protected] Internet: www.Phytoplan.de PHYTOPLAN ® Dear customer, we are pleased to introduce our new catalogue for the year 2006. Therein you will find many new products and also a greater range in the qualities of the compounds differing in the degre of purity and the documents delivered. Please decide which item is the proper for your purpose. All substances are provided with a certificate of analysis of the batch delivered. This includs the analytical data shown in the second column 'documents' of the catalogue. The reference substances mostly have a purity greater than 99.0% determined by HPLC-DAD. Enclosed you will find a comprehensive documentation about the identity and purity determinations. All these compounds are provided with a certificate of analysis including HPLC-DAD, TLC, 1H-NMR, 13C-NMR, UV, IR, MS. Depending on the compound other determinations like elemental analysis, optical rotation, content of water have ben made. Larger quantities of order may cfrome a longer delivery period. All substances which are only delivered with a HPLC-Chromatogram can also be obtained as documented reference substance on demand. In this case we will send you an individual offer. If you ned one or more compounds not listed, even from a definite plant, we will proof the possibility of supply. The requirements for the documentation and specification will be suited to your request.
    [Show full text]
  • Review Article Novel Investigations of Flavonoids As Chemopreventive Agents for Hepatocellular Carcinoma
    Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 840542, 26 pages http://dx.doi.org/10.1155/2015/840542 Review Article Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma Chen-Yi Liao,1,2 Ching-Chang Lee,1 Chi-chang Tsai,1 Chao-Wen Hsueh,1 Chih-Chiang Wang,1 I-Hung Chen,1 Ming-Kai Tsai,1 Mei-Yu Liu,1 An-Tie Hsieh,1 Kuan-Jen Su,1 Hau-Ming Wu,1 Shih-Chung Huang,1 Yi-Chen Wang,1 Chien-Yao Wang,1 Shu-Fang Huang,1 Yen-Cheng Yeh,1 Ren-Jy Ben,1 Shang-Tao Chien,3 Chin-Wen Hsu,4 and Wu-Hsien Kuo1 1 Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan 2Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No.325,Section2,Cheng-KungRoad,Neihu,Taipei114,Taiwan 3Department of Pathology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan 4Department of General Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan Correspondence should be addressed to Wu-Hsien Kuo; [email protected] Received 2 September 2015; Accepted 19 October 2015 Academic Editor: Javier G. Gallego Copyright © 2015 Chen-Yi Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis.
    [Show full text]
  • Induction of Apoptosis by Casticin in Cervical Cancer Cells Through Reactive Oxygen Species-Mediated Mitochondrial Signaling Pathways
    ONCOLOGY REPORTS 26: 1287-1294, 2011 Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways DAN CHEN, JIANGUO CAO, LI TIAN, FEI LIU and XIFENG SHENG Medical College, Hunan Normal University, Changsha 410013, P.R. China Received May 13, 2011; Accepted June 20, 2011 DOI: 10.3892/or.2011.1367 Abstract. Casticin, one of the main components from Fructus cancer cases are diagnosed every year, with a five-year survival Viticis, has been reported to inhibit the growth of various cancer rate of about only 52% (3,4). Currently, we generally utilize cells, including the human cervical cancer cell line HeLa. The radiotherapy and/or chemotherapy as a strategy in the clinical purpose of this study was to examine the apoptotic activity and treatment of cervical cancer, thereby inducing apoptosis in molecular mechanism of casticin action on human cervical tumor cells (5-8). However, conventional therapeutic drugs cancer cells. The apoptotic activity of casticin on human cervical not only trigger apoptosis but also exert lethality on normal cancer HeLa, CasKi, SiHa and peripheral blood mononuclear cells, resulting in serious toxicity (5-8). Therefore, clinically cells (PBMCs) was measured using a histone/DNA ELISA speaking, it is important for us to develop effective, new treat- assay, flow cytometry with propidium iodide (PI) staining and ments for human cervical cancer that can induce apoptosis DNA agarose gel electrophoresis. The mitochondrial membrane with higher selectivity and lower toxicity. potential and reactive oxygen species (ROS) production were Casticin is one of the main components from Fructus evaluated by flow cytometry analysis.
    [Show full text]
  • Secondary Metabolites
    PLANT SECONDARY METABOLITES WWW.TRC-CANADA.COM +1 (416) 665-9696 www.trc-canada.com 2 Brisbane Road, Toronto [email protected] Plant Secondary Metabolites Product CAS No CAT No Acanthopanax senticosides B 114902-16-8 Please Inquire Acetyl resveratrol 42206-94-0 R150055 Acetylshikonin 24502-78-1 Please Inquire Acronycine 7008-42-6 Please Inquire Acteoside 61276-17-3 V128000 Agrimol B 55576-66-4 Please Inquire Alisol-B-23-acetate 26575-95-1 A535970 Alisol-C-monoacetate 26575-93-9 Please Inquire Alizarin 72-48-0 A536600 Alkannin 517-88-4 Please Inquire Allantoin 97-59-6 A540500 Allantoin-13C2,15N4 1219402-51-3 A540502 Alliin 556-27-4 A543530 Aloe emodin 481-72-1 A575400 Aloe-emodin-d5 1286579-72-3 A575402 Aloenin A 38412-46-3 Please Inquire Aloin A 1415-73-2 A575415 Amentoflavone 1617-53-4 A576420 Amygdalin 29883-15-6 A576840 Andrographolide 5508-58-7 A637475 Angelicin 523-50-2 A637575 Anhydroicaritin 118525-40-9 I163700 Anisodamine 55869-99-3 Please Inquire Anthraquinone 84-65-1 A679245 Anthraquinone-D8 10439-39-1 A679247 Apigenin 520-36-5 A726500 Apigenin-d5 263711-74-6 A726502 Araloside X 344911-90-6 Please Inquire www.trc-canada.com I +1 (416) 665-9696 I [email protected] Plant Secondary Metabolites Arbutin 497-76-7 A766510 Arbutin-13C6 A766512 Arctigenin 7770-78-7 A766580 Arctiin 20362-31-6 A766575 Aristolochic acid I 313-67-7 A771300 Aristolochic acid II 475-80-9 A771305 Aristolochic acid sodium salt 10190-99-5 Please Inquire Aristololactam 13395-02-3 A771200 Artemisinin 63968-64-9 A777500 Artemisinin-d3 176652-07-6 A777502 Asiatic
    [Show full text]