The Autopsy Pathology of Sepsis-Related Death
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Large Pink Inclusions in Multiple Myeloma Cells
Journal of Blood Disorders, Symptoms & Treatments Case Report Large Pink Inclusions in Multiple Myeloma Cells This article was published in the following Scient Open Access Journal: Journal of Blood Disorders, Symptoms & Treatments Received July 28, 2017; Accepted August 05, 2017; Published August 11, 2017 Juan Zhang1, Mingyong Li1*, Xianyong Jiang2 and Yuan He1 Abstract 1Clinical Laboratory of Sichuan Academy of Medical Objective: Several intracytoplasmic morphological changes in the plasma cells of Science & Sichuan Provincial People’s Hospital, multiple myeloma have been described previously, especially the Auer rod-like inclusions, Chengdu, Sichuan, China but large pink inclusions have not been reported yet. In this paper, we intend to report a rare 2 Haematology Bone Marrow Inspection laboratory case of inclusions in multiple myeloma. of Peking Union Medical College Hospital, Beijing, China Methods: Bone marrow aspiration from the right superior iliac spine was examined twice. Cells were stained with “Wright-Giemsa” method and also analyzed by flow cytometry, immunohistochemical staining and fluorescence in situ hybridization (FISH). Bone scan demonstrated bilateral ribs, thoracic vertebrae, with multiple low density shadows, which was confirmed subsequently as a lytic lesion on CT scanning. Complete blood count, serum chemistry and coagulation tests were also examined. Results: Bone marrow aspirate from the right superior iliac spine at the time of myeloma diagnosis showed about 58.5% of all nucleated cells being plasma cells, of which many had large pink intracytoplasmic inclusions. Repeat bone marrow biopsy later showed persistence of these morphological findings. All of Flow cytometry, immunohistochemistry and FISH examination support the diagnosis of multiple myeloma. Conclusion: This is the first time to report a multiple myeloma case with such giant pink inclusions. -
Tumor Destruction and Kinetics of Tumor Cell Death in Two Experimental Mouse Tumors Following Photodynamic Therapy1
[CANCER RESEARCH 45, 572-576, February 1985] Tumor Destruction and Kinetics of Tumor Cell Death in Two Experimental Mouse Tumors following Photodynamic Therapy1 Barbara W. Henderson,2 Stephen M. Waldow, Thomas S. Mang, William R. Potter, Patrick B. Malone, and Thomas J. Dougherty Division ot Radiation Biology, Department of Radiation Medicine, Roswell Park Memorial Institute, Buffalo, New York 14263 ABSTRACT rapid tumor necrosis (8, 11). Preceding tumor necrosis are pronounced changes in the vascular system of the tumor (3, 5, The effect of photodynamic therapy (PDT) on tumor growth 23). as well as on tumor œil survival in vitro and in vivo was studied In vitro, dose-dependent (photosensitizer + light) photody in the EMT-6 and RIF experimental mouse tumor systems. In namic cell killing is characterized by cell lysis within 1 hr after a vitro, RIF cells were more sensitive towards PDT than were lethal PDT dose (1) and can be achieved in all cell types studied EMT-6 cells when incubated with porphyrin (25 u,g/m\, dihema- thus far, normal as well as malignant (2, 6,14). toporphyrin ether) and subsequently given graded doses of light. Despite extensive in vivo and in vitro studies, it has not yet In vivo, both tumor types responded to PDT (EMT-6, dihemato- been established whether tumor cell killing in vivo is governed porphyrin ether, 7.5 mg/kg; RIF, dihematoporphyrin ether, 10 by the same mechanism as is cell killing in vitro. To answer this mg/kg; both followed 24 hr later by 135 J of light at 630 nm/sq question, we studied the relationship between tumor destruction, cm) with severe vascular disruption and subsequent disappear tumor cure, and tumor cell survival kinetics in 2 experimental ance of tumor bulk. -
Uses of Pathological Testimony and Autopsy Reports at Trial J
University of Arkansas at Little Rock William H. Bowen School of Law Bowen Law Repository: Scholarship & Archives Faculty Scholarship 1983 When Death is the Issue: Uses of Pathological Testimony and Autopsy Reports at Trial J. Thomas Sullivan University of Arkansas at Little Rock William H. Bowen School of Law, [email protected] Follow this and additional works at: http://lawrepository.ualr.edu/faculty_scholarship Part of the Constitutional Law Commons, and the Criminal Procedure Commons Recommended Citation J. Thomas Sullivan, When Death is the Issue: Uses of Pathological Testimony and Autopsy Reports at Trial, 19 Willamette L. Rev. 579 (1983). This Article is brought to you for free and open access by Bowen Law Repository: Scholarship & Archives. It has been accepted for inclusion in Faculty Scholarship by an authorized administrator of Bowen Law Repository: Scholarship & Archives. For more information, please contact [email protected]. WHEN DEATH IS THE ISSUE: USES OF PATHOLOGICAL TESTIMONY AND AUTOPSY REPORTS AT TRIALt J. THOMAS SULLIVAN* "Death is at the bottom of everything... Leave death to the professionals. " Calloway, The Third Man Trial lawyers often must present or confront evidence concern- ing the death of a party, victim or witness in the course of litigation. Clearly, the fact of death is a key issue considered in homicide' and wrongful death actions.' It may also prove significant in other pro- ceedings, either as the focal point of litigation-as in contested pro- bate matters-or in respect to some collateral matter, such as the death of a witness who might otherwise testify.' Generally, the party t Copyright, 1982 * B.A., University of Texas at Austin; J.D., Southern Methodist University; LLM Can- didate, University of Texas at Austin; Appellate Defender, New Mexico Public Defender Department. -
Role of the Microbiology Laboratory in Infection Control
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 3: Role of the Microbiology Laboratory in Infection Control Author Mohamed Benbachir, PhD Chapter Editor Gonzalo Bearman MD, MPH, FACP, FSHEA, FIDSA Topic Outline Key Issues Known Facts Suggested Practice Suggested Practice in Under-Resourced Settings Summary References Chapter last updated: January, 2018 KEY ISSUES The microbiology laboratory plays an important role in the surveillance, treatment, control and prevention oF nosocomial inFections. The microbiologist is a permanent and active member oF the infection control committee (ICC) and the antimicrobial stewardship group (ASG). Since most of the inFection control and antimicrobial stewardship programs rely on microbiological results, quality assurance is an important issue. KNOWN FACTS The microbiologist is a daily privileged interlocutor oF the infection control team (inFection control doctor and inFection control nurse) and the antimicrobial stewardship working group. The First task oF the microbiology laboratory is to accurately, consistently and rapidly identiFy the responsible agents to species level and identify their antimicrobial resistance patterns. Traditional microbiologic methods remain suboptimal in providing rapid identification and susceptibility testing. There is a growing need for more rapid and reliable laboratory results. Important progress made in the fields of instruments, reagents and techniques have made it easier to adapt to the important changes oF the clinical microbiology context e.g. increasing use of microbiology tests, shortage of qualiFied personnel. There is also a growing demand For quality in clinical laboratories and more and more countries are elaborating national regulations. 1 The microbiology processes are becoming increasingly more complex. InFormatics are playing an increasing role in the improvement oF these processes in terms oF workFlow, timeliness and cost. -
Skin Microbiota: a Source of Disease Or Defence? A.L
FROM BENCH TO BEDSIDE DOI 10.1111/j.1365-2133.2008.08437.x Skin microbiota: a source of disease or defence? A.L. Cogen,* V. Nizetà§ and R.L. Gallo à Departments of *Bioengineering, Medicine, Division of Dermatology and àPediatrics, School of Medicine, and §Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, U.S.A. Summary Correspondence Microbes found on the skin are usually regarded as pathogens, potential patho- Richard L. Gallo. gens or innocuous symbiotic organisms. Advances in microbiology and immu- E-mail: [email protected] nology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host–microbe interaction. Cur- Accepted for publication 30 September 2007 rent data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple Key words symbiotic microbes but rather as mutualistic. This review will summarize current bacteria, immunity, infectious disease information on bacterial skin flora including Staphylococcus, Corynebacterium, Propioni- bacterium, Streptococcus and Pseudomonas. Specifically, the review will discuss our cur- Conflicts of interest rent understanding of the cutaneous microbiota as well as shifting paradigms in None declared. the interpretation of the roles microbes play in skin health and disease. Most scholarly reviews of skin microbiota concentrate on ence inflammatory bowel disease,2 and how lactobacilli in the understanding the population structure of the flora inhabiting intestine educate prenatal immune responses. These findings the skin, or how a subset of these microbes can become complement several studies that suggest disruption in micro- human pathogens. -
Health Sciences Center
Faculty of Allied Health Sciences Handbook: 2020-2021 KUWAIT UNIVERSITY HEALTH SCIENCES CENTRE 1 | P a g e KUWAIT UNIVERSITY HEALTH SCIENCES CENTRE FACULTY OF ALLIED HEALTH SCIENCES Established: 1982 HANDBOOK 2020-2021 2 | P a g e Department of MEDICAL LABORATORY SCIENCES [MLS] 3 | P a g e DEPARTMENT OF MEDICAL LABORATORY SCIENCES Medical Laboratory Sciences offers opportunities for those interested in biological and chemical sciences, leading to a career in the health service or in research. Medical laboratory scientists are professionals who perform laboratory tests and analyses that assist physicians in the diagnosis and treatment of patients. They also assist in research and the development of new laboratory tests. The various studies include chemical and physical analysis of body fluids (clinical chemistry and urinalysis); examination of blood and its component cells (haematology); isolation and identification of bacteria, fungi, viruses and parasites (clinical microbiology and parasitology); testing of blood serum for antibodies indicative of specific diseases (immunology and serology) and collection, storage of blood, pretransfusion testing and other immunohaematological procedures (blood banking). In addition, medical laboratory scientists prepare tissues for histopathological, cytological and cytogenetic examination. They must know the theory and scientific fundamentals as well as the procedures for testing. Medical laboratory scientists work in hospital clinical laboratories, medical schools, research institutions, public health agencies and related organizations. MISSION AND OBJECTIVES Mission The mission of the Department of Medical Laboratory Sciences is to educate and train skillful, knowledgeable and committed Medical Laboratory Scientists who have breadth of knowledge and competence in the various aspects of Medical Laboratory Sciences, who shall adhere to professional ethics, and who can contribute successfully as Medical Laboratory Scientists in the health care team. -
Bacterial Pseudomycetoma (Botryomycosis) in an FIV-Positive Cat
獣医臨床皮膚科 16 (2): 61–65, 2010 Case Report Bacterial Pseudomycetoma (Botryomycosis) in an FIV-positive Cat FIV陽性猫にみられた細菌性偽菌腫(ボトリオミセス症)の1例 Tae Murai1)*, Kyohei Yasuno2), Kinji Shirota2, 3) 1)Kinder-Care Veterinary Clinic, 2)Research Institute of Biosciences and 3)Laboratory of Veterinary Pathology, Azabu University 村井 妙 1)* 安野恭平 2) 代田欣二 2, 3) 1)キンダーケア動物病院,2)麻布大学附置生物科学総合研究所,3)麻布大学獣医病理学研究室 Abstract: A 2.5-year-old spayed female domestic short-haired cat presented with more than a month’s history of a thickly crusted, purulent draining lesion on the shoulder area. Prior to the lesion’s formation, the cat had been repeatedly scratching the shoulder. Histological examination of skin biopsy specimens revealed both discrete and confluent pyogranulomas with fibroplasias and characteristic granules composed of gram-positive cocci surrounded by an eosinophilic amorphous substance. The histopathological findings were consistent with bacterial pseudomycetoma. The skin lesion was successfully treated with systemic and topical administration of antibiotics for about 4 months. However, occasional scratching continued, leading to the development of a small erosion in the same area. The present cat was antigen-positive for feline immunodeficiency virus, and it showed symptoms potentially caused by feline immunodeficiency syndrome. Decreased immune competence might contribute to the pathogenesis of bacterial pseudomycetoma. Key words: bacterial pseudomycetoma, botryomycosis, cat 要 約:2.5歳齢,避妊済みの雑種猫が,頚背部に著しく厚い痂疲を伴う排膿性皮疹を呈し来院した。 病変は当初激しいそう痒から始まり,やがて掻爬部位に一致して瘻孔の形成を認めた。病変部の病 -
WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA). -
Severe Sepsis and Septic Shock Antibiotic Guide
Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Severe Sepsis and Septic Shock Antibiotic Guide Table 1: Antibiotic selection options for healthcare associated and/or immunocompromised patients • Healthcare associated: intravenous therapy, wound care, or intravenous chemotherapy within the prior 30 days, residence in a nursing home or other long-term care facility, hospitalization in an acute care hospital for two or more days within the prior 90 days, attendance at a hospital or hemodialysis clinic within the prior 30 days • Immunocompromised: Receiving chemotherapy, known systemic cancer not in remission, ANC <500, severe cell-mediated immune deficiency Table 2: Antibiotic selection options for community acquired, immunocompetent patients Table 3: Antibiotic selection options for patients with simple sepsis, community acquired, immunocompetent patients requiring hospitalization. Risk Factors for Select Organisms P. aeruginosa MRSA Invasive Candidiasis VRE (and other resistant GNR) Community acquired: • Known colonization with MDROs • Central venous catheter • Liver transplant • Prior IV antibiotics within 90 day • Recent MRSA infection • Broad-spectrum antibiotics • Known colonization • Known colonization with MDROs • Known MRSA colonization • + 1 of the following risk factors: • Prolonged broad antibacterial • Skin & Skin Structure and/or IV access site: ♦ Parenteral nutrition therapy Hospital acquired: ♦ Purulence ♦ Dialysis • Prolonged profound • Prior IV antibiotics within 90 days ♦ Abscess -
Year 11 GCSE History Paper 1 – Medicine Information Booklet
Paper 1 Medicine Key topics 1 and 2 (1250-1500, 1500-1700) Year 11 GCSE History Paper 1 – Medicine Information booklet Medieval Renaissance 1250-1500 1500-1750 Enlightenment Modern 1900-present 1700-1900 Case study: WW1 1 Paper 1 Medicine Key topics 1 and 2 (1250-1500, 1500-1700) Key topic 1.1 – Causes of disease 1250-1500 At this time there were four main ideas to explain why someone might become ill. Religious reasons - The Church was very powerful at this time. People would attend church 2/3 times a week and nuns and monks would care for people if they became ill. The Church told people that the Devil could infect people with disease and the only way to get better was to pray to God. The Church also told people that God could give you a disease to test your faith in him or sometimes send a great plague to punish people for their sins. People had so much belief in the Church no-one questioned the power of the Church and many people had believed this explanation of illness for over 1,000 years. Astrology -After so many people in Britain died during the Black Death (1348-49) people began to look for new ways to explain why they became sick. At this time doctors were called physicians. They would check someone’s urine and judge if you were ill based on its colour. They also believed they could work out why disease you had by looking at where the planets were when you were born. -
Understanding Cancer Tutorial Information for Teachers
Understanding Cancer Tutorial Information for Teachers Understanding Cancer Tutorial • This tutorial was adapted from the Understanding Cancer: Cancer Tutorial available at http://www.cancer.gov/cancertopics/ understandingcancer/cancer • There are two forms for this PPT: – Teacher Presentation version (with a script) – Student Handout version (if printing, specify black/ white on print menu) R Understanding Cancer Tutorial Information for Teachers • The National Cancer Institute has produced a series of cancer related PowerPoint tutorials. These are available as downloadable format at http://www.cancer.gov/cancertopics/ understandingcancer. • Each PowerPoint in this series includes a teacher script. Once these have been downloaded, you may modify the slide show and print student handouts. R Understanding Cancer Teacher Information Developed by: Lewis J. Kleinsmith, Ph.D. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen Discusses and illustrates what cancer is, explains the link between genes and cancer, and discusses what is known about the causes, detection, and diagnosis of the disease. These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain. Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes. R Cancer R Understanding Cancer Developed by: Lewis J. Kleinsmith, Ph.D. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen Discusses and illustrates what cancer is, explains the link between genes and cancer, and discusses what is known about the causes, detection, and diagnosis of the disease. -
Septic Shock V9.0 Patient Flow Map
Septic Shock v9.0 Patient Flow Map Approval & Citation Summary of Version Changes Explanation of Evidence Ratings Patient presents to the ED with fever and/or concern for infection and ED sepsis score ≥ 6 ! BPA fires Use the ED Suspected Septic Shock RN and Well-appearing patients should be placed pathway for all ill on the appropriate ED CSW pathway for Provider appearing patients their underlying condition (e.g. ED No including HemOnc/BMT, Huddle: HemOnc BMT Suspected Infection, ED Central Line Infection Is the patient ill Suspected Central Line Infection, ED and Neonates appearing? Neonatal Fever) Yes ED Septic Shock Pathway • Use ED Suspected Septic Shock Plan • Antibiotics and blood cultures for specific populations included Inpatient Admit Criteria Does NOT meet Inpatient Admit Minute criteria • Resolution of hypotension and no • Admit to ICU ongoing signs of sepsis after ≤ 40 ml / 60 Huddle: YES NO • Follow ICU Septic Shock Pathway kg NS bolus Does patient meet • Use PICU/CICU Septic Shock Admit • First dose antibiotics administered Inpatient admit Plan • RISK to follow criteria? • Antibiotics, blood cultures for specific populations included in sub plans Previously healthy > 30 days RISK RN to follow all • Admit to General Medicine patients admitted with • Follow Admit from ED Septic Shock concern for sepsis Pathway • Use Inpatient Septic Shock Plan ! Concern for evolving sepsis Previously healthy < 30 days Any • Admit to General Medicine admitted • Call RRT or Code Blue • Follow Neonatal Fever Pathway patient with • Follow Inpatient