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Israel Partnership for Research October 18 - 21, 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP FOR RESEARCH OCTOBER 18 - 21, 2013 An International Scientific Symposium focused on the latest advances in Cardiovascular, Cancer and Neurobiology Research Symposium and associated grants have been generously supported by: D. Dan & Betty Kahn Foundation | Meredith and David Kaplan A. Alfred Taubman Medical Research Institute and other generous supporters of the U-M – Israel Partnership for Research TABLE OF CONTENTS SYMPOSIUM AGENDA 1-5 ABSTRACTS (IN ORDER OF PRESENTATION) SUNDAY Ami Aronheim 8 Omer Berenfeld 9 Peleg Hasson & Santhi Ganesh 10 Marcelle Machluf & Jérôme Kalifa 11 Ofer Binah & Daniel Michele 12 Doron Aronson 13 Oren Schuldiner 15 Izhak Kehat 16 Shelly Tzlil 17 Orit Kollet 18 Zaid Abbasi 19 Yuval Shaked 20 Eran Elinav 21 Ronen Rubinshtein 22 Orly Reiner 23 Ofer Fainaru 24 MONDAY Adam Stein 26 Henry Paulson 27 Mordechai Choder 28 Michal Schwartz 29 José Jalife 30 Gad Rennert 31 Theodore Lawrence 32 Eran Hornstein 33 Ivan Maillard 34 Ariel Roguin 35 Zvulun Elazar 36 Michael Aviram 37 Eva Feldman 38 Zvi Livneh 39 David Pinsky 40 Amir Landesberg 41 Berta Strulovici 43 CONTACT INFORMATION University of Michigan 46 Technion Institute of Technology 48 Weizmann Institute of Science 51 EXTRA PAGES FOR NOTE TAKING 54-58 SYMPOSIUM AGENDA SUNDAY, OCTOBER 20, 2013 SAMUEL AND JEAN FRANKEL CARDIOVASCULAR CENTER MARVIN AND BETTY DANTO AUDITORIUM 8:00-8:30 am CONTINENTAL BREAKFAST 8:30-8:40 am WELCOME & OPENING REMARKS David Pinsky (UM) MODERATORS: Donna Martin (UM) / Hector Valdivia (UM) 8:42-9:52 am PRESENTATIONS 8:42-8:54 Ami Aronheim (Technion): Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy Omer Berenfeld (UM): Murine Models of Two Novel Gain-of-Function Mutations in Kcnj2 Reproduce Distinct Clinical Arrhythmias 8:56-9:08 Peleg Hasson (Technion) & Santhi Ganesh (UM): TGF-beta and lysyl oxidase interactions in arterial development and remodeling 9:10-9:22 Marcelle Machluf (Technion) & Jérôme Kalifa (UM): Site Specific Ultrasound Enabled Cardiac Anti Fibrotic Gene Therapy 9:24-9:36 Ofer Binah (Technion) & Daniel Michele (UM): Induced pluripotent stem cell derived cardiac myocytes for testing therapeutic approaches for dystrophic cardiomyopathy 9:36-9:50 Doron Aronson (Technion): Patients with acute myocardial infarction and severe obstructive coronary atherosclerosis display distinct peripheral blood gene expression profiles 9:52-10:07 am BREAK MODERATORS: Daniel Michele (UM) / Ofer Binah (Technion) 10:07-11:28 am PRESENTATIONS 10:07-10:16 Oren Schuldiner (Weizmann): Mechanisms of neuronal remodeling 10:18-10:30 Izhak Kehat (Technion): Mechanisms of cardiac concentric and eccentric hypertrophy 10:32-10:44 Shelly Tzlil (Technion): Cardiac Cell Mechanosensing 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP | 1 10:46-10:58 Orit Kollet (Weizmann): Regulation of hematopoietic stem cells and the bone marrow microenvironment 11:00-11:12 Zaid Abbasi (Technion): Aorto-caval fistula in rat: A unique model of volume-overload congestive heart failure and cardiac hypertrophy 11:14-11:28 Yuval Shaked (Technion): Host response to cancer therapy may promote tumor re-growth and metastasis spread 11:28 am-12:08 pm WORKING LUNCH BREAK MODERATORS: Santhi Ganesh (UM) / Peleg Hasson (Technion) 12:08-1:02 pm PRESENTATIONS 12:08-12:20 Eran Elinav (Weizmann): Neighborly relations: host microbiota interactions in health and disease 12:22-12:34 Ronen Rubinshtein (Technion): Usefulness of Coronary Computed Tomography Angiography for Prediction of Late Cardiovascular Outcome Events in Patients with a Chest Pain Syndrome 12:36-12:48 Orly Reiner (Weizmann): Unconventional roles of the complement pathway in the developing brain 12:50-1:02 Ofer Fainaru (Technion): Angiogenesis in cancer and placentation 1:02-1:15 pm CLOSING REMARKS Boaz Golany (Technion) 2 | 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP MONDAY, OCTOBER 21, 2013 A. ALFRED TAUBMAN BIOMEDICAL SCIENCE RESEARCH BUILDING D. DAN AND BETTY KAHN AUDITORIUM 7:30-8:00 am CONTINENTAL BREAKFAST IN SEMINAR BREAKOUT ROOMS, LEVEL 1 8:00-8:20 am WELCOME & OPENING REMARKS David Pinsky (UM) / Michael Aviram (Technion) / Zvi Livneh (Weizmann) MODERATORS: Dean Brenner (UM) / Gad Rennert (Technion) 8:20-9:56 am PRESENTATIONS 8:20-8:32 Adam Stein (UM): The PTIP containing histone methyltransferase complex is necessary for the development of compensated cardiac hypertrophy. 8:34-8:46 Henry Paulson (UM): Toward understanding and treating polyglutamine neurodegeneration 8:48-9:00 Mordechai Choder (Technion): Gene Expression Is A Circular System 9:02-9:14 Michal Schwartz (Weizmann): A paradigm shift in the perception of brain-immune system dialogue in neurodegenerative diseases and implications for therapeutic vaccination for ALS and Alzheimer’s disease 9:16-9:28 José Jalife (UM): Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation 9:30-9:42 Gad Rennert (Technion): Gene-environment interactions APC I1307K as model of high prevalence, low penetrance genetic variant of clinical importance 9:44-9:56 Theodore Lawrence (UM): Combining Targeted Therapies with Chemoradiation in the Treatment of Pancreatic Cancer 9:56-10:10 am BREAK MODERATORS: Moshe Talpaz (UM) / Yehoash Raphael (UM) 10:10 am-12:00 pm PRESENTATIONS 10:10-10:22 Eran Hornstein (Weizmann): Causes and consequences of dysregulated microRNAs in ALS 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP | 3 10:24-10:36 Ivan Maillard (UM): Blockade of individual Notch ligands and receptors controls graft-versus-host disease 10:37-10:49 Ariel Roguin (Technion): Cardiac Imaging and Radiation 10:51-11:03 Zvulun Elazar (Weizmann): Ubiquitin like proteins and early stages of autophagosome formation 11:05-11:17 Michael Aviram (Technion): HDL - associated Paraoxonase1 (PON1) attenuates Atherosclerosis development: PON1 role in Cholesterol Efflux stimulation 11:19-11:31 Eva Feldman (UM): Dysregulation of miRNAs in sporadic amyotrophic lateral sclerosis 11:33-11:45 Zvi Livneh (Weizmann): DNA repair – from molecular mechanisms to cancer prevention 11:47-11:59 David Pinsky (UM): Protection Against Vascular Injury by Enzymatic Dissipation of Intravascular Nucleotides 12:00-1:00 pm LUNCH MODERATORS: Omer Berenfeld (UM) / Ami Aronheim (Technion) 1:00-1:25 pm REMARKS Dean Amir Landsberg (Technion) Dean Yehuda G. Assaraf (Technion) Dean Pini Bar Yoseph (Technion) 1:25-4:50 pm BREAKOUT SESSIONS A. ALFRED TAUBMAN BIOMEDICAL SCIENCE RESEARCH BUILDING LEVEL 1: SEMINAR ROOMS A, B, C The seminar room will be set-up for small group discussion with seating for 6 to 8 attendees at each table. Session hosts will provide a topic introduction which will be followed by small group discussion. A list of conversation starters will be provided at each table for use as needed. 1:25-1:30 INTRODUCTION FOR BREAKOUT SESSIONS: David Pinsky (UM) 1:30-3:05 BREAKOUT SESSION I Latest /Cutting-edge Advances in Personalized Medicine: From Gene Discovery to Designer Drugs Introductory Presentation & Small Group Discussions BREAKOUT SESSION I HOSTS: David Sherman (UM) Hans W. Vahlteich Professor of Medicinal Chemistry Professor of Medicinal Chemistry 4 | 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP David Sherman (UM) (cont.) Professor of Microbiology & Immunology Professor of Chemistry Professor of Life Sciences James Shayman (UM) Professor of Pharmacology Professor of Internal Medicine Alan Saltiel (UM) Mary Sue Coleman Director, Life Sciences Institute John Jacob Abel Professor in the Life Sciences Professor of Internal Medicine Molecular and Integrative Physiology Berta Strulovici (Weizmann) Director, National Center for Personalized Medicine Vicki Ellingrod (UM) John Gideon Searle Professor Professor of Pharmacy Shaomeng Wang (UM) Warner-Lambert/Parke-Davis Professor of Medicine Professor of Internal Medicine Professor of Pharmacology Professor of Medicinal Chemistry 3:05-3:20 pm BREAK MODERATORS: Jérôme Kalifa (UM) / Marcelle Machluf (Technion) 3:20-4:50 pm BREAKOUT SESSIONS 3:20-4:50 BREAKOUT SESSION II Biomedical Device Entrepreneurship From Medical Ideas to the Medical Market Introductory Presentation & Small Group Discussions BREAKOUT SESSION II HOSTS: Eliezer Shalev (Technion) Dean, Rappaport Faculty of Medicine, Technion Ron Ferber Co-founder and President of HoMedics 4:50-5:00 pm CLOSING REMARKS Alan Saltiel (UM) 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP | 5 7 SUNDAY, OCTOBER 20, 2013 | 2013 UNIVERSITY OF MICHIGAN – ISRAEL PARTNERSHIP AMI ARONHEIM, PhD Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy Lilach Koren1, Izhak Kehat2, Yuval Shaked3 and Ami Aronheim1 1Department of Molecular Genetics 2Department of Physiology 3Department of Pharmacology The Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, 1 Efron St. Bat-Galim, Haifa 31096, Israel Cardiac hypertrophy is an adaptive response to various mechanophysical and pathophysiological stresses. However, when chronic stress is sustained, the beneficial response turns into a maladaptive process that eventually leads to heart failure. Considerable efforts are being directed towards developing mice models and understanding the processes that lead to cardiac hypertrophy. ATF3 is an immediate early transcription factor whose expression is induced in various cardiac stress models but has been reported to have conflicting functional significance in cardiac hypertrophy. To
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