Margono et al. Stomatological Dis Sci 2020;4:3 Stomatological DOI: 10.20517/2573-0002.2019.18 Disease and Science Meta-Analysis Open Access Clinical effectiveness of compounded topical medications in oral medicine: a meta-analysis Her Basuki Margono1, Irna Sufiawati2 1Oral Medicine Residency Program, Faculty of Dentistry, Padjadjaran University, Bandung 40132, West Java, Indonesia. 2Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Bandung 40132, West Java, Indonesia. Correspondence to: Dr. Irna Sufiawati, Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University: Jl. Sekeloa Selatan I, Bandung 40132, West Java, Indonesia. E-mail:
[email protected] How to cite this article: Margono HB, Sufiawati I. Clinical effectiveness of compounded topical medications in oral medicine: a meta-analysis. Stomatological Dis Sci 2020;4:3. http://dx.doi.org/10.20517/2573-0002.2019.18 Received: 16 Oct 2019 First Decision: 11 Nov 2019 Revised: 14 May 2020 Accepted: 21 Jul 2020 Published: 19 Aug 2020 Academic Editor: Letizia Perillo Copy Editor: Cai-Hong Wang Production Editor: Jing Yu Abstract Aim: To assess the evidence of the efficacy and safety of compounded topical medications in oral medicine cases. Methods: Electronic databases were searched from inception to October 2019 for studies that evaluated compounded topical medications in oral medicine cases to assess their efficacy and safety. Search terms included drug compounding, topical administration, clinical efficacy, and oral lesions. Only randomized controlled trials (RCTs) or cross-over trials of compounded topical drug versus non-compounded drug or placebo or standard treatment were included. The exclusion criteria included compounded topical medications with herbal ingredients in the intervention group to compare with the non-compounded drug.