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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 23, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from The Epidemiology of Chronic Pain in Children and Adolescents: A Protocol for a Systematic Review Update Journal: BMJ Open ManuscriptFor ID peerbmjopen-2020-043675 review only Article Type: Protocol Date Submitted by the 11-Aug-2020 Author: Complete List of Authors: Langley, Charlotte; IWK Health Centre, Centre for Pediatric Pain Research Tutelman, Perri; Dalhousie University, Department of Psychology and Neuroscience; IWK Health Centre, Centre for Pediatric Pain Research Parker, Jennifer; IWK Health Centre, Centre for Pediatric Pain Research Chambers, Christine; Dalhousie University, Department of Psychology; IWK Health Centre, Centre for Pediatric Pain Research Finley, Allen; Dalhousie University, Department of Anesthesia, Pain Management & Perioperative Medicine; IWK Health Centre, Centre for Pediatric Pain Research Chapman, Darlene; IWK Health Centre, Health Sciences Library Jones, Gareth; University of Aberdeen, Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health Macfarlane, Gary; University of Aberdeen, Epidemiology Group and http://bmjopen.bmj.com/ Aberdeen Centre for Arthritis and Musculoskeletal Health Marianayagam, Justina; Patient Partner and Medical Student; Northern Ontario School of Medicine Keywords: EPIDEMIOLOGY, PAEDIATRICS, PAIN MANAGEMENT on September 23, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 20 BMJ Open 1 2 3 BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from 4 5 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on September 23, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 20 BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from 1 1 2 3 The Epidemiology of Chronic Pain in Children and Adolescents: A Protocol for a 4 Systematic Review Update 5 6 1 1,2 1 1,2,3* 7 Charlotte L. Langley +, Perri R. Tutelman +, Jennifer A. Parker , Christine T. Chambers , 8 G. Allen Finley1,4, Darlene Chapman5, Gareth T. Jones6, Gary J. Macfarlane6, 9 Justina Marianayagam7 10 11 1IWK Health Centre, Centre for Pediatric Pain Research, Halifax, NS Canada; 2Dalhousie 12 13 3 14 University, Department of Psychology and Neuroscience, Halifax, Canada; Dalhousie 15 16 University, DepartmentFor of Pediatrics, peer Halifax, review Canada; 4Dalhousie only University, Department of 17 18 Anesthesia, Pain Management & Perioperative Medicine, Halifax, Canada; 5IWK Health Centre, 19 20 6 21 Health Sciences Library, IWK Health Centre; University of Aberdeen, Epidemiology Group and 22 23 Aberdeen Centre for Arthritis and Musculoskeletal Health, Aberdeen, Aberdeen, UK; 7Patient 24 25 Partner and Medical Student, Northern Ontario School of Medicine. 26 27 28 29 30 CLL and PRT contributed equally to this article 31 32 33 *Correspondence to: http://bmjopen.bmj.com/ 34 35 Dr. Christine T. Chambers 36 Centre for Pediatric Pain Research 37 IWK Health Centre (K8536) 38 5850/5980 University Ave 39 40 Halifax, NS B3K 6R8, Canada. 41 [email protected] on September 23, 2021 by guest. Protected copyright. 42 43 44 45 Word Count: 1770 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 20 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from 2 1 2 3 ABSTRACT 4 5 6 Introduction: Chronic pain, defined as persistent or recurring pain lasting longer than three 7 8 months, is a common childhood problem and can profoundly impact children’s physical, 9 10 psychological, and social functioning. The last comprehensive systematic review estimating the 11 12 prevalence of chronic pain in children and adolescents was published in 2011. Since then, the 13 14 15 literature on pediatric chronic pain has grown substantially. This manuscript outlines a protocol 16 For peer review only 17 for an updated systematic review to provide updated estimates of the prevalence of various forms 18 19 of chronic pain in children and adolescence. The review will also examine the relationship 20 21 22 between sociodemographic and psychosocial factors related to chronic pain prevalence. 23 24 Methods and Analysis: This review will follow PRISMA guidelines. We will search EMBASE, 25 26 PubMed, CINAHL, and PsycINFO for observational studies published in English between 2009 27 28 29 and 2020 reporting population-based estimates of chronic non-disease-related pain prevalence in 30 31 children or adolescents (age 19 years). Two independent reviewers will screen the titles and 32 33 abstracts retrieved from the search based on predefined eligibility criteria. The full texts of http://bmjopen.bmj.com/ 34 35 36 relevant studies will then be assessed by two reviewers. Studies meeting inclusion criteria will be 37 38 categorized according to the type of pain investigated: headache only, abdominal pain only, back 39 40 pain only, musculoskeletal pain, combined pain, and other/general pain. Data will be extracted 41 on September 23, 2021 by guest. Protected copyright. 42 43 using customized forms and studies will be assessed for risk of bias using a 10-item tool 44 45 developed by Hoy et al. (2012). A narrative synthesis will summarize the prevalence estimates of 46 47 pediatric chronic pain and associated sociodemographic and psychosocial correlates. Meta- 48 49 analyses and meta-regressions will be performed if the data permit. 50 51 52 Ethics and dissemination: Ethical approval is not required. Findings will be disseminated 53 54 through publication in an academic journal, presentations at conferences, and in various media. 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 20 BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021. Downloaded from 3 1 2 3 PROSPERO registration number: Submitted to PROSPERO on July 22, 2020. Currently 4 5 6 awaiting registration number. 7 8 9 10 11 12 13 14 15 16 For peer review only 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 http://bmjopen.bmj.com/ 34 35 36 37 38 39 40 41 on September 23, 2021 by guest. Protected copyright. 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 20 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-043675 on 16 February 2021.
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