WEGART NOVINKY – DECEMBER 2010 – 2. Časť
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Identification of Multiple Risk Loci and Regulatory Mechanisms Influencing Susceptibility to Multiple Myeloma
Corrected: Author correction ARTICLE DOI: 10.1038/s41467-018-04989-w OPEN Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma Molly Went1, Amit Sud 1, Asta Försti2,3, Britt-Marie Halvarsson4, Niels Weinhold et al.# Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. 1234567890():,; We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregu- lation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM. Correspondence and requests for materials should be addressed to K.H. (email: [email protected]) or to B.N. (email: [email protected]) or to R.S.H. (email: [email protected]). #A full list of authors and their affliations appears at the end of the paper. NATURE COMMUNICATIONS | (2018) 9:3707 | DOI: 10.1038/s41467-018-04989-w | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | DOI: 10.1038/s41467-018-04989-w ultiple myeloma (MM) is a malignancy of plasma cells consistent OR across all GWAS data sets, by genotyping an Mprimarily located within the bone marrow. -
Efterklang Og Sjællands Symfoniorkester: Konservatoriets Koncertsal, København - Anmeldelse - GAFFA.Dk 11/10/12 12.29
Efterklang og Sjællands Symfoniorkester: Konservatoriets Koncertsal, København - Anmeldelse - GAFFA.dk 11/10/12 12.29 FORSIDE NYHEDER ANMELDELSER ARTIKLER ALBUM PÅ VEJ KONKURRENCER GALLERIER PLAYLISTER MAGASIN Du er ikke logget ind — Log ind / Opret bruger Annonce Din annonce her? GAFFA SHOP Efterklang & The Danish National Chamber Orchestra: Performing Parades (CD/DVD) Kr. 139,00 Køb på GAFFA Shop Efterklang: An Island (DVD) + Se hele galleriet Kr. 179,00 Køb på GAFFA Shop + Lineup Anmeldelse / Live / Onsdag d. 10-10-2012 kl. 09:26 Efterklang: Caravan (7" Vinyl) Sjællands Efterklang og Sjællands Symfoniorkester Kr. 59,00 Symfoniorkester under Køb på GAFFA Shop dirigent André de Ridder Konservatoriets Koncertsal, København, Efterklang: tirsdag d. 9. oktober 2012 Efterklang: I Was Playing Drums (7" Mads Brauer (keys, Vinyl) elektronik) Casper Anmeldt af Rune Schlosser Kr. 39,00 Køb på GAFFA Shop Clausen (sang, Foto: Michael Boe Laigaard (www.michaelboe.com) perkussion) Efterklang: Magic Chairs Rasmus Stolberg (bas, Kr. 139,00 vibrafon, synth) Køb på GAFFA Shop GAFFA 5 stjerner Ekstramusikere: Peter Broderick (keys, Læserne 5,67 stjerner i snit (efter 3 stemmer) kor) Budgie (trommer, Annonce Din annonce her? perkussion) Katinka Anmeld selv ved at logge ind og føre musen over stjernerne ovenfor. Fogh Vindelev (kor) Clara Bryld (kor) Sidsel Aja Eriksen (kor) Knivskarpe nuancer blev forstærket til Efterklang-gensyn + Sætliste Godt 18 måneders koncertpause fra Danmark kom til en ende, da Efterklang med Hollow Mountain deres seneste bedrift Paramida indtog Konservatoriets Koncertsal sammen med Sjællands Symfoniorkester. Koncerten havde verdenspremiere i Sydney i maj, Apples men denne aften var det med André de Ridder bag dirigentstokken, som sammen Sedna med den danske trio leverede de fine kompositioner meget overbevisende. -
Efterklang & Copenhagen Phil – Gavmilde Symbioser
Efterklang & Copenhagen Phil – gavmilde symbioser - Soundvenue - musik og mode 11/10/12 12.31 Tegn abonnement Tilmeld nyhedsbrev | Glemt kodeord? | Husk Din e-mail Dit kodeord Log ind 6 x Soundvenue + Urbanears høretelefoner Kun 475,- Forside Nyheder Style Anmeldelser Live-anmeldelser Top Tracks Features Konkurrencer Søgeord Søg Efterklang & Copenhagen Phil – Seneste nyt Spotify i krise gavmilde symbioser Streamming-tjenesten kæmper med seriøse, økonomiske udfordringer. Jonas Sølberg 10. oktober 2012 Del med andre Kunstner Spillested Efterklang & Konservatoriets Patos Black Cheese- Copenhagen Phil Koncertsal mixtape er ude 'Black Cheese Mixxtape Vol.2' er Efterklang-kollaboratør, og denne udkommet som gratis app til din aften også opvarmer, Peter Broderick smartphone. havde på 20 minutter, i balancegang mellem det løsslupne og det storladne, Guide: 10 fede events til serveret et perfekt oplæg til Casper Kulturnatten Clausen, inden Efterklangs frontmand, Vi har fundet Kulturnattens ti bedste backet af band, korsangere og events indenfor musik og mode, Sjælland Symfoniorkesters 34 mand blandt andet med Nikolaj Nørlund, Foto: Tue Falck Olsen store klassiske ensemble, hoppede på Martin Hall og modeshow på is. scene som naboens charmerende og kejtede knægt. Nyheder Med ’Piramida’s trekantede og cirkulære symbolik dinglende fra loftet og projiceret på bagvæggen var det selvsagt, at denne aften i overdådighedens Video: Rhye har tegn skulle åbne i det uendeligt hule bjerg ’Hollow Mountain’, som må have kærlighedskvaler i afmonteret de få mash-up-skeptiske tilstedeværende tilskuere. København Halvt danske Rhye har smidt en video Aftenen stod derefter på en parade af ’Piramida’-sange tunet – hverken for til 'The Fall'. meget eller for lidt – med klassiske arrangementer og elektroniske samples. -
The Routledge Companion to Remix Studies
THE ROUTLEDGE COMPANION TO REMIX STUDIES The Routledge Companion to Remix Studies comprises contemporary texts by key authors and artists who are active in the emerging field of remix studies. As an organic interna- tional movement, remix culture originated in the popular music culture of the 1970s, and has since grown into a rich cultural activity encompassing numerous forms of media. The act of recombining pre-existing material brings up pressing questions of authen- ticity, reception, authorship, copyright, and the techno-politics of media activism. This book approaches remix studies from various angles, including sections on history, aes- thetics, ethics, politics, and practice, and presents theoretical chapters alongside case studies of remix projects. The Routledge Companion to Remix Studies is a valuable resource for both researchers and remix practitioners, as well as a teaching tool for instructors using remix practices in the classroom. Eduardo Navas is the author of Remix Theory: The Aesthetics of Sampling (Springer, 2012). He researches and teaches principles of cultural analytics and digital humanities in the School of Visual Arts at The Pennsylvania State University, PA. Navas is a 2010–12 Post- Doctoral Fellow in the Department of Information Science and Media Studies at the University of Bergen, Norway, and received his PhD from the Program of Art and Media History, Theory, and Criticism at the University of California in San Diego. Owen Gallagher received his PhD in Visual Culture from the National College of Art and Design (NCAD) in Dublin. He is the founder of TotalRecut.com, an online com- munity archive of remix videos, and a co-founder of the Remix Theory & Praxis seminar group. -
WEGART NOVINKY Oktober
WEGART NOVINKY – OKTÓBER 2010 Antony And The Johnsons – Swanlights (Rouhg Trade) Swanlights je štvrtým štúdiovým albumom skupiny Antony And The Johnsons . Kým predošlé albumy boli presved čivé svojou bezbrannos ťou či triezvos ťou, nový album zaujme predovšetkým širokou škálou emócií, ktoré prechádzajú od momentov dojímajúcich hlbokým žia ľom až po chvíle výbušnej radosti. Skupina zárove ň rozšírila svoju zvukovú paletu, používajúc zvláštne perkusné prvky, efektované gitary, ako aj symfonické dychové a slá čikové aranžmány, ktoré celý album sce ľujú. Swanlights vychádza na labeli Rough Trade Records s bonusovou skladbou "Flétta", ktorú s Antonym naspievala Björk. CD 16,00 € (482 SK) Kat. č. RTRADCD573 EAN 883870057325 Antony And The Johnsons – Thank You For Your Love E.P. (Rough Trade) Tracklist: 1 Thank You For Your Love 2 You Are The Treasure 3 My Lord My Love 4 Pressing On 5 Imagine CDEP 9,00 € (271 Sk) / 12" 12,00 € (362 Sk) Kat. č. RTRADSCD588 EAN 883870058827 Belle And Sebastian – Write About Love (Rough Trade) Po takmer piatich rokoch Belle And Sebastian vydávajú nový album Write About Love . Na rozdiel od predošlých albumov, tento vznikol v relatívne krátkom období. Po tom ako sa vo februári 2010 dala skupina znovu dokopy, nasledovalo obdobie skladania a skúšania a cesta do renomovaného losangeleského štúdia, kde už za čiatkom júna bolo hotových 14 skladieb, z ktorých 11 tvorí tento album. Ako vždy predtým, všetky skladby čerpajú z pesni čkárskych zru čností samotnej skupiny, no tento krát bolo prizvaných aj nieko ľko hostí, a tak na albume možno po čuť spieva ť napríklad Norah Jones alebo anglickú here čku Carey Mulligan. -
The Sky Is Always BLU
G O B L U ! The Sky is Always BLU S P E C I A L VOLUME 1, ISSUE 2 WINTER 2011 P O I N T S O F INTEREST: The Chakras Voices of BLU: Welcome Family! Queen Sage Says… By O’Shea” Myles our new additions including the “Yes! Active links!!” We recipro- “Queen Sage Says…”, Spirituali- cate. This means to email us or Feeling “Blue” A Welcome to the second issue of ty, and Health/Wellness sec- view web pages directly, press the Black Lesbian Mental “The Sky is Always tions. Also, with a little help CTRL-key plus use your cursor to Health Crisis BLU” (SAB) newsletter! Since we last spoke, there have been from technology, the SAB News- click on the link provided Baby Steps to creating some enhancements made to and...PRESTO CHANGE-O!...you healthy finances our quarterly publication. Now, are where you want to be. don't fret! Your favorites are BLU + YOU Check-in with Timika still here, including the “nitty- PLEASE don’t forget that SAB is Jackson; author of gritty” on community happen- “Voices Within” “for us, by us, with us, and about ings and events, but we’ve got us” so make sure to review the some additions that we think end of each segment to see where you may enjoy. Our pages now you can submit your contribu- embody more of the essence tions. For instance, this current that makes BLU. What is that issue was made possible from essence? Its you! Our hope is to contributions from the following provide you with the same BLU Retreat community mem- pillars of information, re- bers: Angie Maldonado, Eko Ca- sources, and experiences that nillas, Keisean Raines, Lelani are cultivated during the BLU McKenzie, O’Shea” Myles, Saun- retreat. -
60 Minutes of Efterklang
9. oktober – 12. oktober 2012 60 MINUTES NEWS NO.6 EFTERKLANG Solister / Efterklang Dirigent / André de Ridder Musik / Efterklang – nyt album: Piramida Arrangører / Daniel Bjarnason (Sigur Rós, Múm) / Karsten Fundal (Under Byen, Choir of Young Believers) / Missy Mazzoli (Kronos Quartet, Victoire) Support / Peter Broderick Tirsdag 9. oktober 2012 fra kl. 19:30 (EKSTRAKONCERT) Konservatoriets Koncertsal (tidl. Radiohuset) Onsdag 10. oktober 2012 fra kl. 19:30 (UDSOLGT) Konservatoriets Koncertsal (tidl. Radiohuset) Fredag 12. oktober 2012 fra kl. 19:30 Kulturværftet, Helsingør 60 MINUTES OF EFTERKLANG Husk at forudbestille den særlige 60 minutes menu, som Efterklang har de senere år rejst jorden tynd og er kendte kan nydes på Den Musikalske over hele verden for deres fortryllende liveshows, hvor JIVLM\WN\M[]XXTMZM[IN ÆMZMXZWUQVMV\MO¥[\MU][QSMZM Markedsplads før koncerten. Udover hundredvis af koncerter på rockspillesteder har Efterklang også optrådt i store koncertsale verden over i Se menuen på side 3. [IUIZJMRLMUMLVWOTMIN ^MZLMV[JML[\MSTI[[Q[SMWZSM[\ZM -N\MZSTIVO[U][QS]LSWUUMZXsLM\XZM[\QOQ¦[MMVOMT[SM XTILM[MT[SIJ),WOLMZM[VaMWONRMZLMITJ]UPiramida DEN MUSIKALSKE MARKEDSPLADS – MZKMV\Z]UNWZLQ[[M[XMKQMTTMSWVKMZ\IN\MVMZ·JIVLM\[ MØD ARRANGØREN BAG MUSIKKEN N¦Z[\MSWVKMZ\MZQ,IVUIZSMN\MZMVXI][MXs UsVMLMZ -N\MZSTIVO^QT[IUUMVUML;R¥TTIVL[;aUNWVQWZSM[\MZ Før koncerten åbner ’Den Musikalske Markedsplads’, +WXMVPIOMV8PQT[XQTTMLMZM[VaMITJ]UUMLWZSM[\MZ- [WU^IZUMZX]JTQS]UWX\QTIN\MVMV[SWVKMZ\0MZ IZZIVOMUMV\MZIN SWUXWVQ[\MZVM3IZ[\MV.]VLITWO SIVX]JTQS]UU¦LM3IZ[\MV.]VLITQ[IU\ITMUML -
Schedule A: Aria Licensing - Copyright Owners
SCHEDULE A: ARIA LICENSING - COPYRIGHT OWNERS BEGGARS GROUP MEDIA LIMITED www.beggars.com BINNABURRA FILM CO PTY LTD Address withheld BLACK MARKET MUSIC www.blackmarketmusic.com.au COLOSSAL RECORDS OF AUSTRALIA PTY LTD Address withheld COMPASS BROS RECORDS PTY LTD www.compassbros.com.au COOKING VINYL AUSTRALIA www.cookingvinylaustralia.com CREATE CONTROL PTY LTD www.create-control.com DEX AUDIO PTY LTD T/A NEW MARKET MUSIC www.newmarketmusic.com EMI MUSIC (AUSTRALIA) PTY LTD www.emimusic.com.au EXIST RECORDINGS www.existrecordings.com HEAD RECORDS* www.headrecords.com HEAVEN MUSIC AUSTRALIA PTY LTD Address withheld INERTIA PTY LTD www.inertia-music.com KOBALT MUSIC PUBLISHING www.kobaltmusic.com LEONIE MACPHERSON Address withheld LIBERATION MUSIC PTY LTD www.liberation.com.au LIOR ATTAR www.lior.com.au MIDNIGHT RECORDS PTY LTD Address withheld MODERN MUSIC PTY LTD www.modernmusic.com.au NLV Records www.nlvrecords.com. ORIGIN RECORDINGS PTY LTD www.originmusic.com.au PRO AGENCY GMBH www.pro-agency.net PUBLIC OPINION * Address withheld RED REBEL MUSIC www.redrebelmusic.com REGENCY MEDIA PTY LTD T/A SHOCK www.shockrecords.com.au ENTERTAINMENT* REMOTE CONTROL RECORDS PTY LTD www.remotecontrolrecords.com.au Updated December 2020 RUBBER MUSIC PTY LTD T/A RUBBER RECORDS www.rubberrecords.com RUFUS RECORDS www.rufusrecords.com.au SAMPLES 'N' SECONDS RECORDS PTY LTD www.gotye.com SONY MUSIC ENTERTAINMENT (AUSTRALIA) LTD www.sonymusic.com.au SOUNDPROOF AUSTRALIA PTY LTD Address withheld TRUSTEE FOR THE GEORGI FAMILY TRUST Address withheld TWO SHOES PTY LTD Address withheld UNDERCOVER MUSIC PTY LTD www.undercovermusic.com.au UNIFIED MUSIC GROUP PTY LTD www.unifiedmusicgroup.com UNIVERSAL MUSIC AUSTRALIA LIMITED www.umusic.com.au WARNER MUSIC AUSTRALIA PTY LTD www.warnermusic.com.au XELON www.xelonentertainment.com Updated December 2020 * Labels controlled by this Licensor are excluded from the grant of rights in relation to Music Videos (only sound recording rights are granted). -
Journey Into Sound Radio Darmstadt - Radar 103,4 Mhz / Livestream: Live.Radiodarmstadt.De Artist Track Album Label Sendetermin
On Air every months's first Thursday 2100 - 2300 CET Journey into Sound Radio Darmstadt - RadaR 103,4 MHz / Livestream: live.radiodarmstadt.de Artist Track Album Label Sendetermin !!! AM/FM Strange Weather, isn't it? Warp 01.07.2010 Individual Dance Safarai !!! Hello? Is this Thing on? Hello? Is this thing on? Warp 28.08.2004 Math on lone Beats !!! Hello? Is this Thing on? V/A Warp 02.12.2010 Warp20 (Elemental) Christmas Mix Vol. IX !!! Shit, Scheisse, Merde Pt.2 2 Tracks Clean Edits Warp 22.05.2004 A Doctor's Journey !!! Steady as the Sidewalk cracks Strange Weather, isn't it? Warp 02.09.2010 Sweet voodoo message music !!! Sunday 5:17 am Hello? Is this thing on? Warp 28.08.2004 Math on lone Beats !((OrKZa1 How to kill N'Sync How to kill N'Sync Commie 26.04.2003 Open word soundscapes (Read by) Andreas Pietschmann CD1 Carlos Ruiz Zafón - Der Schatten des Windes Hoffmann und Campe 05.07.2007 La Sombra del Viento (Read by) Andreas Pietschmann CD2 Carlos Ruiz Zafón - Der Schatten des Windes Hoffmann und Campe 05.07.2007 La Sombra del Viento (read by) Andreas Pietschmann Mpipidi und der Motlopi-Baum Nelson Mandela - Meine afrikanischen Hoffmann und Campe 29.05.2005 Lieblingsmärchen African Myths (read by) Christian Brückner Löwe , Hase und Hyäne Nelson Mandela - Meine afrikanischen Hoffmann und Campe 29.05.2005 Lieblingsmärchen African Myths (read by) Eva Mattes Die Schlange mit den 7 Köpfen Nelson Mandela - Meine afrikanischen Hoffmann und Campe 29.05.2005 Lieblingsmärchen African Myths (read by) Judy Winter Bescherung bei König Löwe Nelson Mandela - Meine afrikanischen Hoffmann und Campe 29.05.2005 Lieblingsmärchen African Myths (read by) Leslie Malton Die Mutter, die zu Staub zerfiel Nelson Mandela - Meine afrikanischen Hoffmann und Campe 29.05.2005 Lieblingsmärchen African Myths .. -
Genome-Wide Association Study Identifies Susceptibility Loci for B-Cell Childhood Acute Lymphoblastic Leukemia
This is a repository copy of Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. White Rose Research Online URL for this paper: https://eprints.whiterose.ac.uk/129865/ Version: Published Version Article: Vijayakrishnan, Jayaram, Studd, James, Broderick, Peter et al. (47 more authors) (2018) Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Nature Communications. 1340. ISSN 2041-1723 https://doi.org/10.1038/s41467-018-03178-z Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ ARTICLE DOI: 10.1038/s41467-018-03178-z OPEN Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia Jayaram Vijayakrishnan1, James Studd 1, Peter Broderick 1, Ben Kinnersley 1, Amy Holroyd1, Philip J. Law 1, Rajiv Kumar2, James M. Allan3, Christine J. Harrison4, Anthony V. Moorman4, Ajay Vora5, Eve Roman6, Sivaramakrishna Rachakonda2, Sally E. Kinsey7, Eamonn Sheridan8, Pamela D. -
Musique MOZ Mozart Ill
3 Wolfgang Amadeus MOZART Musique MOZ Mozart ill. de Pablo Corréa Généralités BD Music, 2010 Si pour communiquer, Mozart 3 Jean Sébastien BACH utilise les formes et le langage BAC Bach musical de son époque sans rien ill. Silvestro Nicolaci ; scénario de révolutionner, il est un des rares Giancarlo Dimaggio artistes à pouvoir exprimer avec BD Music, 2009 une telle puissance les sentiments Jean-Sébastien Bach représente un les plus forts et les plus des plus hauts sommets de la pensée contradictoires que peut éprouver mondiale. Ce grand mystique laisse la psyché humaine. Depuis la une oeuvre aux multiples niveaux de sonate jusqu'aux symphonies en passant par ses lecture qui va du simple plaisir merveilleux concertos de piano et son incomparable jusqu'à l'ésotérisme, par son emploi musique de chambre, cette BD accompagnée de extrêmement savant des nombres deux disques retraçent l’œuvre du compositeur. illustrant la perfection divine. Son (2 CD + 1 BD) oeuvre est multiple et aborde tous les genres à l'exception notable de l'opéra. 3 Maurice RAVEL (2 CD + 1 BD) RAV Ravel ill. de Michel Conversin 3 Frédéric CHOPIN BD Music, 2010 CHO Chopin Il ne se passe pas un jour sans qu'on ill. de Wozniak & Marjorie Guigu joue quelque part dans le monde BD Music, 2009 son Boléro - qu'il prenait si peu au La musique de Chopin n'est que sérieux - les Tableaux d'une force, originalité et nouveauté. Les exposition, les Concertos pour innovations techniques révélées par piano, La Valse ou Daphnis et sa musique, ainsi que certains de ses Chloé. -
Dischi Compatti
>PRODUZIONE & STUDI Antony & The Johnsons Swanlights Label: Secretly Canadian Formato: CD, download Uff, una fatica incommensurabile e anche un dolore grande dover ammettere che questo album di Antony risulti un’eterna introduzione a qualcosa che non arriva. E non è neanche un’intro particolarmente speciale. Il suono è il suono magico di sempre, ma non c’è l’altra Dischi Compatti faccia della medaglia di sempre: l’intuizione melodica, il genio, la sorpresa emotiva, il Uscite discografiche scelte e recensite da Stefano Lentini trasporto meravigliato. Una moneta ad una faccia sola è una moneta attaccata sull’asfalto. Pur sempre di valore, ma inutilizzabile. Speriamo che Antony sappia staccarla, ripulirla e ridarcela nella sua magnifica lucentezza. Temper Trap Ti piace? Ascolta i Felice Brother: Yonder is the Clock. Americani anche loro, meno classici Conditions e più folk ma ugualmente intensi. Label: Liberation (AUS) – Infectious Records (UK) Formato: CD, download La voce dei Temper Trap, Dougy Mandagi, è una linea fine e solida di intimismo e autocompiacimento, vanità e forza interiore. Conditions, album d’esordio della Andreya Triana band australiana è stato prodotto da Jim Abbiss, produttore inglese di Arctic Lost Where I Belong Monkeys, Kasabian, KT Tunstall. Nel disco troviamo brani come Science of Fear, Label: Ninja Tune Soldier on e Resurrection, destinati ad essere belli per altri dieci anni. Voglia di Formato: CD, download, ed. speciale vinile melodia, voglia di profondità, di ballare, di energia e tempra. Ti piace? Ascolta Alberta Cross: Broken Side of the Time (2009). Il soul sembra sempre cristallizzarsi intorno a qualche suono particolare, alle vocalità calde di Anglo-americani dal nome misterioso: un anagramma da svelare.